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Overview

ID MAG01816
Name HKD2_bin.72
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_E
Class Deferrimicrobia
Order Deferrimicrobiales
Family Deferrimicrobiaceae
Genus
Species
Assembly information
Completeness (%) 75.83
Contamination (%) 5.0
GC content (%) 69.0
N50 (bp) 11,269
Genome size (bp) 2,181,123

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2018

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10018839_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 285.0
HKD2_k127_10018839_1 PFAM aldo keto reductase K07079 - - 0.00000000000000000000000000000000000000000000000000000000001217 220.0
HKD2_k127_10018839_2 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000006877 164.0
HKD2_k127_10018839_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00006682 54.0
HKD2_k127_10106851_0 Belongs to the aconitase IPM isomerase family K01682 - 4.2.1.3,4.2.1.99 0.0 1240.0
HKD2_k127_10106851_1 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 455.0
HKD2_k127_10106851_2 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 451.0
HKD2_k127_10106851_3 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 441.0
HKD2_k127_10106851_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007482 370.0
HKD2_k127_10106851_5 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 343.0
HKD2_k127_10106851_6 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 334.0
HKD2_k127_10106851_7 Protein of unknown function (DUF1318) - - - 0.0000000000000000000000000000008348 124.0
HKD2_k127_10106851_8 - - - - 0.00000000000001639 78.0
HKD2_k127_1019380_0 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003928 277.0
HKD2_k127_1019380_1 pfam abc K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005325 273.0
HKD2_k127_1019380_2 PFAM cobalamin (vitamin B12) biosynthesis CbiM K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005998 250.0
HKD2_k127_1019380_3 nickel-responsive regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000007749 195.0
HKD2_k127_1019380_4 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000008416 174.0
HKD2_k127_1019380_5 PFAM Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000003361 156.0
HKD2_k127_1019380_6 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000000000000003572 123.0
HKD2_k127_1019380_7 cobalt ion transport K02009 - - 0.00000000000001299 86.0
HKD2_k127_1042076_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 578.0
HKD2_k127_1042076_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000007586 266.0
HKD2_k127_1042076_2 NAD(P)H-binding K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000004423 262.0
HKD2_k127_1042076_3 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003787 258.0
HKD2_k127_1042076_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000002717 198.0
HKD2_k127_1042076_5 FES K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000002171 168.0
HKD2_k127_1042076_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000002154 170.0
HKD2_k127_1042076_7 MFS_1 like family - - - 0.000000000000000000000000001923 126.0
HKD2_k127_1042076_8 PFAM glutaredoxin K18917 - 1.20.4.3 0.0000000000006928 80.0
HKD2_k127_1042076_9 Putative regulatory protein - - - 0.000000004304 62.0
HKD2_k127_1046598_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.37e-224 717.0
HKD2_k127_1046598_1 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000131 251.0
HKD2_k127_1242679_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 5.431e-199 628.0
HKD2_k127_1242679_1 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 322.0
HKD2_k127_1242679_2 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 306.0
HKD2_k127_1242679_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000019 256.0
HKD2_k127_1242679_4 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000006824 257.0
HKD2_k127_1246368_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000001033 237.0
HKD2_k127_1274807_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 499.0
HKD2_k127_1274807_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 448.0
HKD2_k127_1274807_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000001373 157.0
HKD2_k127_1274807_3 - - - - 0.00000000000004588 82.0
HKD2_k127_1274807_4 - - - - 0.0000000000000836 81.0
HKD2_k127_1274807_5 Putative zinc-finger - - - 0.0004876 49.0
HKD2_k127_1297541_0 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 494.0
HKD2_k127_1297541_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 409.0
HKD2_k127_1297541_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005778 294.0
HKD2_k127_1297541_3 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001299 279.0
HKD2_k127_1297541_4 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000003144 226.0
HKD2_k127_1297541_5 FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000000000000000000000000000008532 199.0
HKD2_k127_1297541_6 amine dehydrogenase activity - - - 0.000000000000000000000000000000004924 137.0
HKD2_k127_1297541_7 cheY-homologous receiver domain - - - 0.00000000000000002218 96.0
HKD2_k127_1297541_8 Rubrerythrin - - - 0.0002332 50.0
HKD2_k127_1317129_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 361.0
HKD2_k127_1317129_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000000000008189 184.0
HKD2_k127_1317129_2 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000009552 188.0
HKD2_k127_1317129_3 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000009062 123.0
HKD2_k127_1317129_4 Protein of unknown function (DUF3106) - - - 0.00000001565 66.0
HKD2_k127_1317129_5 Putative zinc-finger - - - 0.000001254 58.0
HKD2_k127_1347436_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1491.0
HKD2_k127_1347436_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 659.0
HKD2_k127_1347436_2 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 488.0
HKD2_k127_1347436_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 458.0
HKD2_k127_1347436_4 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 404.0
HKD2_k127_1347436_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 399.0
HKD2_k127_1347436_6 PFAM Aminotransferase class I and II K14261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 352.0
HKD2_k127_1347436_7 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 292.0
HKD2_k127_1347436_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000001635 246.0
HKD2_k127_1347436_9 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000005336 229.0
HKD2_k127_1348907_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 349.0
HKD2_k127_1348907_1 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 0.00000000000000000008629 98.0
HKD2_k127_1348907_2 nucleic acid binding K03698 - - 0.00000000000000002729 83.0
HKD2_k127_142925_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.249e-239 754.0
HKD2_k127_142925_1 Acyl-CoA synthetase (NDP forming) K09181 - - 2.525e-200 645.0
HKD2_k127_142925_10 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000002649 107.0
HKD2_k127_142925_11 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.000000000000000000000005132 113.0
HKD2_k127_142925_2 fumarate reductase, flavoprotein subunit K00239,K00244 - 1.3.5.1,1.3.5.4 9.69e-196 625.0
HKD2_k127_142925_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 558.0
HKD2_k127_142925_4 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 422.0
HKD2_k127_142925_5 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 427.0
HKD2_k127_142925_6 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000007791 254.0
HKD2_k127_142925_7 DRTGG domain K13788 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000288 257.0
HKD2_k127_142925_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000001325 241.0
HKD2_k127_142925_9 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000001446 208.0
HKD2_k127_1496809_0 AcrB/AcrD/AcrF family K03296,K07788,K07789,K18138 - - 0.0 1665.0
HKD2_k127_1496809_1 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1348.0
HKD2_k127_1496809_10 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 398.0
HKD2_k127_1496809_11 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 389.0
HKD2_k127_1496809_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 307.0
HKD2_k127_1496809_13 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 333.0
HKD2_k127_1496809_14 PFAM Cytochrome b b6 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008034 282.0
HKD2_k127_1496809_15 Protein of unknown function (DUF1614) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000803 250.0
HKD2_k127_1496809_16 electron transfer activity K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000000008115 243.0
HKD2_k127_1496809_17 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000001227 246.0
HKD2_k127_1496809_18 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K16168 - - 0.0000000000000000000000000000000000000000000000000000004235 203.0
HKD2_k127_1496809_19 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000006949 186.0
HKD2_k127_1496809_2 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1203.0
HKD2_k127_1496809_20 YceI-like domain - - - 0.0000000000000000000000000000000001351 141.0
HKD2_k127_1496809_21 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000001485 134.0
HKD2_k127_1496809_22 - - - - 0.0000000000000000000000528 102.0
HKD2_k127_1496809_23 Rieske [2Fe-2S] domain - - - 0.000000000000000006675 91.0
HKD2_k127_1496809_24 PFAM aldo keto reductase - - - 0.00000000000232 67.0
HKD2_k127_1496809_25 - - - - 0.0000000003169 72.0
HKD2_k127_1496809_3 cytochrome c - - - 5.33e-251 793.0
HKD2_k127_1496809_4 Carbohydrate phosphorylase K00688 - 2.4.1.1 1.144e-224 709.0
HKD2_k127_1496809_5 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 545.0
HKD2_k127_1496809_6 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 486.0
HKD2_k127_1496809_7 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 458.0
HKD2_k127_1496809_8 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 431.0
HKD2_k127_1496809_9 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 419.0
HKD2_k127_1523940_0 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 500.0
HKD2_k127_1523940_1 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000000000000000000000000009473 251.0
HKD2_k127_1534950_0 Ferritin-like domain - GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896 - 0.0000000000000000000000000000000000000000000000000000000000000000007283 237.0
HKD2_k127_1534950_1 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000000002833 225.0
HKD2_k127_1534950_2 AAA domain, putative AbiEii toxin, Type IV TA system K09817 - - 0.0000000000000000000000000000000000000000000000000000000000004024 232.0
HKD2_k127_1534950_3 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000001311 224.0
HKD2_k127_1534950_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000001785 158.0
HKD2_k127_1534950_5 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000001563 77.0
HKD2_k127_1534950_6 Ferric uptake regulator family K03711 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000007844 62.0
HKD2_k127_1534950_7 AntiSigma factor - - - 0.00002541 55.0
HKD2_k127_1546832_0 response to heat K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1108.0
HKD2_k127_1546832_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007118 497.0
HKD2_k127_1546832_10 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000007605 155.0
HKD2_k127_1546832_11 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000197 165.0
HKD2_k127_1546832_12 Single-strand binding protein family K03111 - - 0.00000000000000000000000000000000000007198 146.0
HKD2_k127_1546832_13 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000001491 147.0
HKD2_k127_1546832_14 SpoVG K06412 - - 0.0000000000000000000000000000002149 125.0
HKD2_k127_1546832_15 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000004985 125.0
HKD2_k127_1546832_17 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000001596 102.0
HKD2_k127_1546832_18 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000003226 90.0
HKD2_k127_1546832_19 Domain of unknown function (DUF1844) - - - 0.0000000000171 70.0
HKD2_k127_1546832_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 476.0
HKD2_k127_1546832_3 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 427.0
HKD2_k127_1546832_4 response regulator K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 404.0
HKD2_k127_1546832_5 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005214 267.0
HKD2_k127_1546832_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000648 254.0
HKD2_k127_1546832_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000006393 197.0
HKD2_k127_1546832_8 His Kinase A (phosphoacceptor) domain K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000002143 203.0
HKD2_k127_1546832_9 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000002025 173.0
HKD2_k127_1564732_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 379.0
HKD2_k127_1564732_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000009478 271.0
HKD2_k127_1564732_2 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.00000000000000000000000000000000000000001578 175.0
HKD2_k127_1564732_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000001764 159.0
HKD2_k127_1564732_4 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000006899 137.0
HKD2_k127_1620347_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K00344,K00966,K01840,K03431,K15778,K16881 - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 8.108e-259 818.0
HKD2_k127_1620347_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 552.0
HKD2_k127_1620347_10 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000002051 228.0
HKD2_k127_1620347_11 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000006356 221.0
HKD2_k127_1620347_12 Stage II sporulation D domain protein K06381 - - 0.0000000000000000000000000000000000000000000002404 183.0
HKD2_k127_1620347_13 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.00000000000000000000000001111 125.0
HKD2_k127_1620347_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 405.0
HKD2_k127_1620347_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 384.0
HKD2_k127_1620347_4 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 397.0
HKD2_k127_1620347_5 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 370.0
HKD2_k127_1620347_6 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 320.0
HKD2_k127_1620347_7 SMART PUA domain containing protein K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 314.0
HKD2_k127_1620347_8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 310.0
HKD2_k127_1620347_9 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003743 251.0
HKD2_k127_1621791_0 SMART Elongator protein 3 MiaB NifB - - - 2.458e-211 684.0
HKD2_k127_1621791_1 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 581.0
HKD2_k127_1621791_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 328.0
HKD2_k127_1621791_3 regulatory protein GntR HTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005187 243.0
HKD2_k127_1621791_4 HD domain K07814 - - 0.000000000000000000000000000000000000000000002264 181.0
HKD2_k127_1621791_5 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000265 173.0
HKD2_k127_1621791_6 sigma factor antagonist activity K04757 - 2.7.11.1 0.000000000000000006716 99.0
HKD2_k127_1621791_7 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 0.00000000005176 67.0
HKD2_k127_1622116_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 564.0
HKD2_k127_1622116_1 acyl-CoA dehydrogenase activity K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 483.0
HKD2_k127_1622116_10 Serine threonine protein kinase - - - 0.00004801 57.0
HKD2_k127_1622116_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 365.0
HKD2_k127_1622116_3 ABC transporter K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000004021 254.0
HKD2_k127_1622116_4 PFAM ABC transporter related K11963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004283 251.0
HKD2_k127_1622116_5 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000003442 240.0
HKD2_k127_1622116_6 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000743 229.0
HKD2_k127_1622116_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000003404 224.0
HKD2_k127_1622116_8 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000009375 224.0
HKD2_k127_1622116_9 Protein of unknown function (DUF2914) - - - 0.0000000006462 68.0
HKD2_k127_1628272_0 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.00000000000000000000000000000000000000000000000005636 194.0
HKD2_k127_1628272_1 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000558 181.0
HKD2_k127_1628272_2 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000008296 71.0
HKD2_k127_1653231_0 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 486.0
HKD2_k127_1653231_1 PFAM regulatory protein LuxR K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 335.0
HKD2_k127_1653231_2 PFAM Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000000000000000000000000000000001285 142.0
HKD2_k127_1677428_0 Phosphoadenosine phosphosulfate reductase family K21947 - 2.8.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 304.0
HKD2_k127_1677428_1 TIGRFAM iron-sulfur cluster binding protein K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006971 261.0
HKD2_k127_1677428_2 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002886 252.0
HKD2_k127_1677428_3 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000001238 216.0
HKD2_k127_1677428_4 PFAM Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.000000000000006458 87.0
HKD2_k127_1677428_5 thiamine diphosphate biosynthetic process K03154 - - 0.000000000000359 71.0
HKD2_k127_1677428_6 - - - - 0.00002869 54.0
HKD2_k127_1677428_7 Glucose / Sorbosone dehydrogenase K21430 - - 0.0003809 48.0
HKD2_k127_1690747_0 Sugar (and other) transporter K03446 - - 5.189e-198 630.0
HKD2_k127_1690747_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 450.0
HKD2_k127_1690747_2 HlyD membrane-fusion protein of T1SS K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003355 291.0
HKD2_k127_1690747_3 Transcriptional regulator K18136 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000001482 217.0
HKD2_k127_1690747_4 GYD domain - - - 0.000000000000000000000000000000000004345 141.0
HKD2_k127_1690747_5 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.00000000000000000000000000000000264 139.0
HKD2_k127_1690747_6 protein with SCP PR1 domains - - - 0.00000000000000000000000000005773 124.0
HKD2_k127_1690747_7 Major Facilitator Superfamily K08223 - - 0.000000000000000004005 86.0
HKD2_k127_1690747_8 Amidohydrolase K07045 - - 0.0000000000001708 82.0
HKD2_k127_174911_0 PFAM Aldehyde dehydrogenase - - - 3.979e-235 737.0
HKD2_k127_174911_1 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K14534 - 4.2.1.120,5.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 542.0
HKD2_k127_174911_10 PFAM Two component regulator propeller - - - 0.0000000000000000000000000002158 127.0
HKD2_k127_174911_2 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 424.0
HKD2_k127_174911_3 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 388.0
HKD2_k127_174911_4 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 361.0
HKD2_k127_174911_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007812 349.0
HKD2_k127_174911_6 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 314.0
HKD2_k127_174911_7 amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001785 285.0
HKD2_k127_174911_8 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000003049 224.0
HKD2_k127_1790514_0 ATPase BadF BadG BcrA BcrD type - - - 1.451e-246 788.0
HKD2_k127_1823282_0 two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 406.0
HKD2_k127_1823282_1 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000004022 263.0
HKD2_k127_1823282_2 Signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000005472 197.0
HKD2_k127_1823282_3 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000127 113.0
HKD2_k127_1826777_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005894 527.0
HKD2_k127_1826777_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 434.0
HKD2_k127_1826777_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 396.0
HKD2_k127_1826777_3 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 379.0
HKD2_k127_1826777_4 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 379.0
HKD2_k127_1833716_0 PFAM Major Facilitator Superfamily K08224 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 417.0
HKD2_k127_1833716_1 THUMP K07444,K12297 - 2.1.1.173,2.1.1.264 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 378.0
HKD2_k127_1833716_10 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000006984 68.0
HKD2_k127_1833716_13 Putative zinc-finger - - - 0.00003306 53.0
HKD2_k127_1833716_2 Magnesium chelatase, subunit ChlI K03404,K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 346.0
HKD2_k127_1833716_3 PFAM MaoC domain protein dehydratase K14449 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 308.0
HKD2_k127_1833716_4 NAD(P)H dehydrogenase (quinone) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007617 273.0
HKD2_k127_1833716_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000317 219.0
HKD2_k127_1833716_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000005363 135.0
HKD2_k127_1833716_7 PFAM Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000278 128.0
HKD2_k127_1833716_8 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000003749 98.0
HKD2_k127_1833716_9 Glutaredoxin - - - 0.0000000000000006229 92.0
HKD2_k127_1886761_0 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009414 314.0
HKD2_k127_1886761_1 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 294.0
HKD2_k127_1886761_2 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005989 267.0
HKD2_k127_1886761_3 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000007812 175.0
HKD2_k127_1886761_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000000002274 178.0
HKD2_k127_1886761_5 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000003745 98.0
HKD2_k127_1899339_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 516.0
HKD2_k127_1899339_1 NAD+ diphosphatase activity K03426,K20449 - 1.3.7.1,3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 317.0
HKD2_k127_1899339_2 Thiamine-binding protein - - - 0.00000000000000000000000000000000000001782 149.0
HKD2_k127_1899339_4 ATP-independent chaperone mediated protein folding K06006 - - 0.00000000005728 68.0
HKD2_k127_192949_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.603e-259 850.0
HKD2_k127_192949_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 483.0
HKD2_k127_192949_10 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000002475 81.0
HKD2_k127_192949_11 PFAM AsmA family K07289 - - 0.000004242 60.0
HKD2_k127_192949_12 Pfam:DUF1049 - - - 0.00002933 56.0
HKD2_k127_192949_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 436.0
HKD2_k127_192949_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 409.0
HKD2_k127_192949_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 382.0
HKD2_k127_192949_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000002333 275.0
HKD2_k127_192949_6 Dimerisation domain of Zinc Transporter K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001121 263.0
HKD2_k127_192949_7 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000003724 243.0
HKD2_k127_192949_8 PFAM Isochorismatase K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000001635 208.0
HKD2_k127_192949_9 Sensory domain found in PocR - - - 0.000000000000000000000000000001434 133.0
HKD2_k127_201322_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 606.0
HKD2_k127_201322_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008602 531.0
HKD2_k127_201322_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000004054 248.0
HKD2_k127_201322_11 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000004623 223.0
HKD2_k127_201322_12 regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000364 177.0
HKD2_k127_201322_13 - - - - 0.0000000000000000000000000000000000000001932 163.0
HKD2_k127_201322_14 domain, Protein - - - 0.0000000000000000000000008827 122.0
HKD2_k127_201322_15 Universal stress protein family - - - 0.0000000000000000000002925 103.0
HKD2_k127_201322_16 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000006487 97.0
HKD2_k127_201322_17 Diguanylate cyclase - - - 0.000000000000000000001146 108.0
HKD2_k127_201322_18 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000005989 102.0
HKD2_k127_201322_19 ATP synthase, subunit C K02124 - - 0.000000000002366 72.0
HKD2_k127_201322_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 457.0
HKD2_k127_201322_20 subunit (C K02119 - - 0.0000000001893 74.0
HKD2_k127_201322_21 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000005377 59.0
HKD2_k127_201322_22 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00005745 53.0
HKD2_k127_201322_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007803 416.0
HKD2_k127_201322_4 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 400.0
HKD2_k127_201322_5 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007808 368.0
HKD2_k127_201322_6 Belongs to the pseudouridine synthase RluA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 360.0
HKD2_k127_201322_7 PFAM V-type ATPase 116 kDa K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007448 339.0
HKD2_k127_201322_8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001578 278.0
HKD2_k127_201322_9 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000004252 252.0
HKD2_k127_2017611_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1137.0
HKD2_k127_2017611_1 General secretory system II protein E domain protein K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 506.0
HKD2_k127_2017611_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 334.0
HKD2_k127_2017611_3 Peptidase family M23 - - - 0.000000000000000000000000000000000000000001848 168.0
HKD2_k127_2017611_4 - - - - 0.000000000612 63.0
HKD2_k127_2017611_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000002234 52.0
HKD2_k127_2079600_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 457.0
HKD2_k127_2079600_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 350.0
HKD2_k127_2079600_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 336.0
HKD2_k127_2079600_3 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000000000000000000000000001228 164.0
HKD2_k127_2079600_5 RDD family - - - 0.0001091 49.0
HKD2_k127_2116262_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000005259 268.0
HKD2_k127_2116262_1 Putative citrate transport - - - 0.0000000000000000000000000000000002025 136.0
HKD2_k127_2116262_2 Belongs to the universal stress protein A family - - - 0.0003154 51.0
HKD2_k127_2133218_0 CBS domain containing protein K00974 - 2.7.7.72 6.129e-262 835.0
HKD2_k127_2133218_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.874e-235 756.0
HKD2_k127_2133218_10 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 376.0
HKD2_k127_2133218_11 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 355.0
HKD2_k127_2133218_12 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 338.0
HKD2_k127_2133218_13 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 300.0
HKD2_k127_2133218_14 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002037 293.0
HKD2_k127_2133218_15 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004337 281.0
HKD2_k127_2133218_16 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000002006 276.0
HKD2_k127_2133218_17 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000005564 262.0
HKD2_k127_2133218_18 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000005635 231.0
HKD2_k127_2133218_19 Virulence activator alpha C-term - - - 0.000000000000000000000000000000000000000000000000000006871 195.0
HKD2_k127_2133218_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009079 605.0
HKD2_k127_2133218_20 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000005646 209.0
HKD2_k127_2133218_21 Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000002588 175.0
HKD2_k127_2133218_22 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000001652 160.0
HKD2_k127_2133218_23 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000003153 145.0
HKD2_k127_2133218_24 SCP-2 sterol transfer family - - - 0.000000000000000000000000000000006487 140.0
HKD2_k127_2133218_25 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000006302 121.0
HKD2_k127_2133218_26 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000001795 130.0
HKD2_k127_2133218_27 - - - - 0.000001311 56.0
HKD2_k127_2133218_3 Fructose-1,6-bisphosphatase K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009483 565.0
HKD2_k127_2133218_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 570.0
HKD2_k127_2133218_5 SCP-2 sterol transfer family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 427.0
HKD2_k127_2133218_6 PFAM DAHP synthetase I K03856,K04516 - 2.5.1.54,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 423.0
HKD2_k127_2133218_7 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 438.0
HKD2_k127_2133218_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 428.0
HKD2_k127_2133218_9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 387.0
HKD2_k127_233694_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 553.0
HKD2_k127_233694_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000005158 175.0
HKD2_k127_233694_2 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000001909 124.0
HKD2_k127_233694_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000003992 76.0
HKD2_k127_233808_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1121.0
HKD2_k127_233808_1 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 514.0
HKD2_k127_233808_10 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000001087 75.0
HKD2_k127_233808_2 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 471.0
HKD2_k127_233808_3 2Fe-2S iron-sulfur cluster binding domain K00240,K00245 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 432.0
HKD2_k127_233808_4 GTP cyclohydrolase I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000097 286.0
HKD2_k127_233808_5 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005533 263.0
HKD2_k127_233808_6 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002284 264.0
HKD2_k127_233808_7 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000164 156.0
HKD2_k127_233808_8 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000006486 107.0
HKD2_k127_233808_9 OmpA family K02557 - - 0.00000000000000000000448 107.0
HKD2_k127_2437959_0 Polysaccharide biosynthesis protein CapD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 542.0
HKD2_k127_2437959_1 - - - - 0.00000000000000000000000000001817 128.0
HKD2_k127_2504534_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 3.111e-212 682.0
HKD2_k127_2504534_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 3.389e-198 642.0
HKD2_k127_2504534_10 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 300.0
HKD2_k127_2504534_11 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 286.0
HKD2_k127_2504534_12 fad dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001811 257.0
HKD2_k127_2504534_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008054 252.0
HKD2_k127_2504534_14 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000005702 230.0
HKD2_k127_2504534_15 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000001017 222.0
HKD2_k127_2504534_16 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000000000000000000886 209.0
HKD2_k127_2504534_17 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000000000000000000000005978 173.0
HKD2_k127_2504534_18 phosphinothricin N-acetyltransferase activity - - - 0.00000000000000000000000000000000000000003753 159.0
HKD2_k127_2504534_19 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000000000305 111.0
HKD2_k127_2504534_2 domain, Protein K01176,K03332 - 3.2.1.1,3.2.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 585.0
HKD2_k127_2504534_20 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000003802 104.0
HKD2_k127_2504534_21 abundant protein - - - 0.00003865 56.0
HKD2_k127_2504534_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 478.0
HKD2_k127_2504534_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 474.0
HKD2_k127_2504534_5 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 462.0
HKD2_k127_2504534_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 414.0
HKD2_k127_2504534_7 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009401 357.0
HKD2_k127_2504534_8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 338.0
HKD2_k127_2504534_9 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 333.0
HKD2_k127_2521288_0 PFAM Aminotransferase, class I K00812,K02028,K12252 - 2.6.1.1,2.6.1.84,3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 357.0
HKD2_k127_2521288_1 Calcineurin-like phosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000005778 187.0
HKD2_k127_2545893_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 524.0
HKD2_k127_2545893_1 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004834 430.0
HKD2_k127_2545893_2 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000001202 145.0
HKD2_k127_2545893_3 SMART protein phosphatase 2C domain protein - - - 0.00000000000000005366 94.0
HKD2_k127_2545893_4 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000015 51.0
HKD2_k127_2551879_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000002019 213.0
HKD2_k127_2551879_1 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.000000004029 64.0
HKD2_k127_2575963_0 carbamoyl transferase, NodU family K00612 - - 7.753e-299 927.0
HKD2_k127_2575963_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 347.0
HKD2_k127_2575963_10 Cbs domain K04767 - - 0.000000000000000000000003091 119.0
HKD2_k127_2575963_11 - - - - 0.000000000000009833 81.0
HKD2_k127_2575963_12 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000001295 68.0
HKD2_k127_2575963_13 transcription activator, effector binding - - - 0.00000134 57.0
HKD2_k127_2575963_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 344.0
HKD2_k127_2575963_3 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 297.0
HKD2_k127_2575963_4 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 312.0
HKD2_k127_2575963_5 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 292.0
HKD2_k127_2575963_6 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.00000000000000000000000000000000000000000000000000000002267 222.0
HKD2_k127_2575963_7 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000004749 194.0
HKD2_k127_2575963_8 nodulation - - - 0.0000000000000000000000000001101 124.0
HKD2_k127_2575963_9 SURF4 family K15977 - - 0.000000000000000000000000004272 115.0
HKD2_k127_2585282_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 604.0
HKD2_k127_2585282_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 554.0
HKD2_k127_2585282_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 307.0
HKD2_k127_2585282_3 reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001529 284.0
HKD2_k127_2585282_4 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000002394 230.0
HKD2_k127_2585282_5 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000005731 233.0
HKD2_k127_2585282_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000734 205.0
HKD2_k127_2585282_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000153 96.0
HKD2_k127_2586402_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 537.0
HKD2_k127_2586402_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 379.0
HKD2_k127_2586402_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003328 278.0
HKD2_k127_2591770_0 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 379.0
HKD2_k127_2591770_1 methylglyoxal synthase activity K01734 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 0.0000000000000000000000000000000000000000000000000000000000009 234.0
HKD2_k127_2591770_2 - - - - 0.0000000000000000000000000000000000000000000704 164.0
HKD2_k127_2591770_3 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000004066 154.0
HKD2_k127_2591770_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000006673 136.0
HKD2_k127_2591770_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000006376 115.0
HKD2_k127_2591770_6 - - - - 0.00000000000000000000000117 109.0
HKD2_k127_2592650_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 603.0
HKD2_k127_2592650_1 THUMP K07444,K12297 - 2.1.1.173,2.1.1.264 0.00000000000000000000000000000000000000000009217 166.0
HKD2_k127_2592650_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000508 104.0
HKD2_k127_2598076_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.395e-245 765.0
HKD2_k127_2598076_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000008646 208.0
HKD2_k127_2645406_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1385.0
HKD2_k127_2645406_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 454.0
HKD2_k127_2645406_2 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 444.0
HKD2_k127_2645406_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 358.0
HKD2_k127_2645406_4 sigma factor activity K02405,K03093 - - 0.0000000000000000000000000000000000000000000000000000000000001603 222.0
HKD2_k127_2645406_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000001027 190.0
HKD2_k127_2645406_6 Thioesterase K18700 - 3.1.2.29 0.000000000000000000000000000000000000000000000006949 180.0
HKD2_k127_2645406_7 RmuC family K09760 - - 0.00000000000000000000000000000000002911 149.0
HKD2_k127_2645406_8 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000001097 76.0
HKD2_k127_2660982_0 Exopolysaccharide biosynthesis protein YbjH - - - 1.889e-231 742.0
HKD2_k127_2660982_1 polysaccharide export K01991 - - 0.00000000007094 67.0
HKD2_k127_2759892_0 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002019 261.0
HKD2_k127_2759892_1 Chorismate mutase K03856,K04092,K04093,K04516,K13853 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000001855 157.0
HKD2_k127_2759892_2 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000006402 148.0
HKD2_k127_2759892_3 Haemolytic - - - 0.0000000000000000000000002845 110.0
HKD2_k127_2759892_4 ABC transporter K06158 - - 0.000004384 53.0
HKD2_k127_2797652_0 Receptor family ligand binding region K01999 - - 3.23e-210 661.0
HKD2_k127_2797652_1 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 460.0
HKD2_k127_2797652_2 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 349.0
HKD2_k127_2797652_3 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 352.0
HKD2_k127_2797652_4 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.0000000000000000000000000000000000006167 158.0
HKD2_k127_2797652_5 - - - - 0.0000000000000000000000003741 108.0
HKD2_k127_2797652_6 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.000000000001006 80.0
HKD2_k127_2841324_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 2.923e-298 923.0
HKD2_k127_2841324_1 PFAM Xanthine uracil vitamin C permease K06901 - - 6.149e-195 617.0
HKD2_k127_2841324_2 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 421.0
HKD2_k127_2841324_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000003352 223.0
HKD2_k127_2841324_4 domain protein K20276 - - 0.0000000000001361 84.0
HKD2_k127_2841324_5 PFAM Class II aldolase K01628 - 4.1.2.17 0.00000006498 63.0
HKD2_k127_2843617_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.857e-237 747.0
HKD2_k127_2843617_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 576.0
HKD2_k127_2843617_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 383.0
HKD2_k127_2843617_3 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 311.0
HKD2_k127_2843617_4 Tetratricopeptide repeat - - - 0.0000008778 63.0
HKD2_k127_2855883_0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - 2.134e-216 693.0
HKD2_k127_2855883_1 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 589.0
HKD2_k127_2855883_2 uridine phosphorylase activity K00757 - 2.4.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 333.0
HKD2_k127_2855883_3 Pfam Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004775 241.0
HKD2_k127_2855883_4 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000004211 241.0
HKD2_k127_2855883_5 DNA-binding transcription factor activity K03892 - - 0.00000000000000000000000000000000000004944 149.0
HKD2_k127_2855883_6 CO dehydrogenase acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.00000000000000002216 97.0
HKD2_k127_2869320_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08357 - - 0.0 1348.0
HKD2_k127_2869320_1 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 9.926e-223 700.0
HKD2_k127_2869320_10 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000006062 181.0
HKD2_k127_2869320_11 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000183 162.0
HKD2_k127_2869320_12 PFAM Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000004658 157.0
HKD2_k127_2869320_13 Diguanylate cyclase - - - 0.0000000000000000000000000000000005675 143.0
HKD2_k127_2869320_14 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000146 146.0
HKD2_k127_2869320_15 Smr domain - - - 0.00000000000000000000000009614 109.0
HKD2_k127_2869320_16 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000001849 122.0
HKD2_k127_2869320_17 membrane transporter protein K07090 - - 0.000000000000000000000004404 113.0
HKD2_k127_2869320_18 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000007112 94.0
HKD2_k127_2869320_2 Elongation factor SelB winged helix 3 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 496.0
HKD2_k127_2869320_3 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 331.0
HKD2_k127_2869320_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 336.0
HKD2_k127_2869320_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005144 273.0
HKD2_k127_2869320_6 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007786 282.0
HKD2_k127_2869320_7 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000001093 281.0
HKD2_k127_2869320_8 Domain of unknown function (DUF4118) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009544 262.0
HKD2_k127_2869320_9 Pfam:DUF162 - - - 0.00000000000000000000000000000000000000000000000000000000000000111 225.0
HKD2_k127_2895840_0 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 588.0
HKD2_k127_2895840_1 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 576.0
HKD2_k127_2895840_2 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 406.0
HKD2_k127_2895840_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000005156 184.0
HKD2_k127_2895840_4 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0000000000000000000000000000000000000000001131 166.0
HKD2_k127_2895840_5 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000004623 151.0
HKD2_k127_2895840_7 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0008193 51.0
HKD2_k127_2909999_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 4.9e-269 845.0
HKD2_k127_2909999_1 PSP1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003604 243.0
HKD2_k127_2909999_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000003407 201.0
HKD2_k127_2909999_3 DNA polymerase III, delta' K02341 - 2.7.7.7 0.000000000000000000000000000000000000001944 165.0
HKD2_k127_2909999_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.00000004258 64.0
HKD2_k127_2921232_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 2.039e-294 927.0
HKD2_k127_2921232_1 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 492.0
HKD2_k127_2921232_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000391 160.0
HKD2_k127_2921232_11 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000058 123.0
HKD2_k127_2921232_12 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000002757 71.0
HKD2_k127_2921232_13 Modulates RecA activity K03565 GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - 0.0000004117 59.0
HKD2_k127_2921232_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 390.0
HKD2_k127_2921232_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 363.0
HKD2_k127_2921232_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 351.0
HKD2_k127_2921232_5 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 314.0
HKD2_k127_2921232_6 PFAM ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 294.0
HKD2_k127_2921232_7 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 285.0
HKD2_k127_2921232_8 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000005054 252.0
HKD2_k127_2921232_9 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000003166 242.0
HKD2_k127_2929392_0 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000591 274.0
HKD2_k127_2929392_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000007198 256.0
HKD2_k127_2929392_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000004762 215.0
HKD2_k127_2929392_3 Nucleotidyl transferase K00966,K16881 - 2.7.7.13,5.4.2.8 0.000000000000000000000000000000000000000000000001611 196.0
HKD2_k127_2929392_4 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000001018 184.0
HKD2_k127_2929392_5 transglycosylase K08309 - - 0.00000000000000000000000000000000541 149.0
HKD2_k127_2929392_6 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000001679 118.0
HKD2_k127_29602_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1274.0
HKD2_k127_29602_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 5.516e-220 694.0
HKD2_k127_29602_2 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 400.0
HKD2_k127_29602_3 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 372.0
HKD2_k127_29602_4 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000008424 262.0
HKD2_k127_29602_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000009632 244.0
HKD2_k127_29602_6 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000009537 236.0
HKD2_k127_29602_7 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.0000000000000000000000000000000000000000000000008616 190.0
HKD2_k127_2979444_0 ATP-dependent DNA helicase activity K16898 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000001661 278.0
HKD2_k127_2988862_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1330.0
HKD2_k127_2988862_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 535.0
HKD2_k127_2988862_10 - - - - 0.00000000000000000000000000000000000000000000000000000002348 209.0
HKD2_k127_2988862_11 PFAM nuclease (SNase domain protein) - - - 0.000000000000000000000000000000000000000001696 163.0
HKD2_k127_2988862_12 - - - - 0.0000000000000000000000000000000000000001263 161.0
HKD2_k127_2988862_13 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000002203 155.0
HKD2_k127_2988862_14 protein conserved in bacteria - - - 0.0000000000000000000000000000004949 127.0
HKD2_k127_2988862_16 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000003326 109.0
HKD2_k127_2988862_17 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000005067 98.0
HKD2_k127_2988862_18 TIM-barrel fold metal-dependent hydrolase K07045 - - 0.00000000000000003496 96.0
HKD2_k127_2988862_19 YtxH-like protein - - - 0.000004527 53.0
HKD2_k127_2988862_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 474.0
HKD2_k127_2988862_3 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 367.0
HKD2_k127_2988862_4 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 366.0
HKD2_k127_2988862_5 Alkaline phosphatase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 331.0
HKD2_k127_2988862_6 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 297.0
HKD2_k127_2988862_7 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000181 301.0
HKD2_k127_2988862_8 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 301.0
HKD2_k127_2988862_9 lysyl-tRNA synthetase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000001609 233.0
HKD2_k127_3036536_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 579.0
HKD2_k127_3036536_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 514.0
HKD2_k127_3036536_2 NUDIX domain K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 347.0
HKD2_k127_3036536_3 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000000139 213.0
HKD2_k127_3036536_4 Predicted membrane protein (DUF2318) - - - 0.00000000000000000000000000000000005965 141.0
HKD2_k127_3036536_5 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000002798 131.0
HKD2_k127_3036536_6 Universal stress protein family - - - 0.0000000000001675 72.0
HKD2_k127_3036536_7 MacB-like periplasmic core domain K02004 - - 0.000000002863 61.0
HKD2_k127_3065542_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 418.0
HKD2_k127_3065542_1 impB/mucB/samB family K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 386.0
HKD2_k127_3065542_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 302.0
HKD2_k127_3065542_3 Biotin/lipoate A/B protein ligase family K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000007997 173.0
HKD2_k127_3065542_5 THUMP - - - 0.00000000000000000000000005001 119.0
HKD2_k127_3071391_0 type IV pilus secretin PilQ K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 424.0
HKD2_k127_3071391_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008199 376.0
HKD2_k127_3071391_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000006141 254.0
HKD2_k127_3071391_3 Pilus assembly protein, PilO K02664 - - 0.000000000000000000000000000000000002064 146.0
HKD2_k127_3071391_4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000565 137.0
HKD2_k127_3071391_5 PFAM Fimbrial assembly family protein K02663 - - 0.000001948 51.0
HKD2_k127_3071391_6 Pilus assembly protein, PilP K02665 - - 0.000003743 58.0
HKD2_k127_3080420_0 Cache domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007449 505.0
HKD2_k127_3080420_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 488.0
HKD2_k127_3080420_2 Pyridoxal-phosphate dependent enzyme K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 451.0
HKD2_k127_3080420_3 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000701 328.0
HKD2_k127_3080420_4 CHRD domain - - - 0.0001427 51.0
HKD2_k127_3093774_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005906 600.0
HKD2_k127_3093774_1 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 559.0
HKD2_k127_3093774_10 metallopeptidase activity K03630 - - 0.000000000000000000000000000000000000007945 153.0
HKD2_k127_3093774_11 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000009584 138.0
HKD2_k127_3093774_12 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000001013 139.0
HKD2_k127_3093774_13 Protein of unknown function DUF58 - - - 0.0000000000000000000000000003512 133.0
HKD2_k127_3093774_14 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000001064 111.0
HKD2_k127_3093774_15 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000002227 82.0
HKD2_k127_3093774_16 Forkhead associated domain - - - 0.000000000007999 76.0
HKD2_k127_3093774_17 deoxyhypusine monooxygenase activity - - - 0.00000006972 62.0
HKD2_k127_3093774_18 Uncharacterized protein conserved in bacteria (DUF2135) - - - 0.00002308 59.0
HKD2_k127_3093774_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009262 383.0
HKD2_k127_3093774_3 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 295.0
HKD2_k127_3093774_4 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001582 279.0
HKD2_k127_3093774_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004814 259.0
HKD2_k127_3093774_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000006784 245.0
HKD2_k127_3093774_7 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.0000000000000000000000000000000000000000009404 164.0
HKD2_k127_3093774_8 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000003393 158.0
HKD2_k127_3093774_9 Domain of unknown function (DUF3488) - - - 0.000000000000000000000000000000000000002428 170.0
HKD2_k127_3103887_0 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 437.0
HKD2_k127_3103887_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007716 290.0
HKD2_k127_3103887_10 -O-antigen K02847,K13009 - - 0.00000000003519 76.0
HKD2_k127_3103887_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001797 267.0
HKD2_k127_3103887_3 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000003744 271.0
HKD2_k127_3103887_4 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000002354 258.0
HKD2_k127_3103887_5 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000013 193.0
HKD2_k127_3103887_6 ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - 0.0000000000000000000000000000000000000000000000000001113 196.0
HKD2_k127_3103887_7 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000114 160.0
HKD2_k127_3103887_8 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000002667 150.0
HKD2_k127_3103887_9 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.00000000000000000000000003308 125.0
HKD2_k127_3105293_0 Belongs to the thiolase family K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 479.0
HKD2_k127_3105293_1 Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.000000000000000000000000000000000000000000000000000000000001419 230.0
HKD2_k127_3108258_0 belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 386.0
HKD2_k127_3108258_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000003629 175.0
HKD2_k127_3148849_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000003381 231.0
HKD2_k127_3148849_1 Carbon-nitrogen hydrolase K13566 - 3.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000911 228.0
HKD2_k127_3148849_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000783 176.0
HKD2_k127_3148849_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000009384 172.0
HKD2_k127_3148849_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.000000000000000000000000000000000001919 152.0
HKD2_k127_3148849_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000008243 139.0
HKD2_k127_3148849_6 Cysteine desulfurase - - - 0.000000000000000000000000000001647 123.0
HKD2_k127_3148849_7 Phosphoribosyl transferase domain - - - 0.000000000000000000000002069 115.0
HKD2_k127_3198778_0 Ferredoxin--NADP reductase K21567 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 304.0
HKD2_k127_3198778_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000001769 76.0
HKD2_k127_3198778_2 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.00000000003453 64.0
HKD2_k127_3198778_3 Thioredoxin-like - - - 0.000001986 61.0
HKD2_k127_3232243_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 4.119e-243 762.0
HKD2_k127_3232243_1 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000002026 198.0
HKD2_k127_3232243_2 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000003887 196.0
HKD2_k127_3232243_3 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.0000000000000000000000000000000000003307 160.0
HKD2_k127_3232243_4 TPM domain K06872 - - 0.00000000000000000000000000118 128.0
HKD2_k127_3232243_5 nucleotidyltransferase activity - - - 0.000000000000000005441 93.0
HKD2_k127_3305208_0 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 424.0
HKD2_k127_3305208_1 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 345.0
HKD2_k127_3305208_2 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 295.0
HKD2_k127_3305208_3 Calcineurin-like phosphoesterase K07096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009281 263.0
HKD2_k127_3305208_4 PFAM Metal-dependent phosphohydrolase, HD - - - 0.000000000000000000001839 106.0
HKD2_k127_3305208_6 Putative regulatory protein - - - 0.0000000000000316 75.0
HKD2_k127_3305208_7 Glutamine amidotransferases class-II K07008 - 3.5.1.118 0.00000000009106 72.0
HKD2_k127_3305208_8 pyrroloquinoline quinone binding - - - 0.0000002968 53.0
HKD2_k127_3468563_0 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 523.0
HKD2_k127_3468563_1 GTP cyclohydrolase I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009248 295.0
HKD2_k127_3468563_2 RibD C-terminal domain - - - 0.00000000000003421 83.0
HKD2_k127_3545310_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 338.0
HKD2_k127_3551719_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 314.0
HKD2_k127_3551719_1 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000004431 70.0
HKD2_k127_3591908_0 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 379.0
HKD2_k127_3591908_1 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002119 270.0
HKD2_k127_3591908_2 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000005404 221.0
HKD2_k127_3591908_3 Protein of unknown function (DUF3617) - - - 0.00000000000000001263 91.0
HKD2_k127_3657306_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 503.0
HKD2_k127_3657306_1 nitric oxide reductase activity K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 409.0
HKD2_k127_3657306_2 regulation of single-species biofilm formation K02342,K03763,K13573 - 2.7.7.7 0.000000000000000000000000000001056 130.0
HKD2_k127_3657306_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K03793 - 1.5.1.33 0.00000000000000000000000000006029 132.0
HKD2_k127_3657306_4 rubredoxin - - - 0.0000000000000000000000008072 104.0
HKD2_k127_3657306_5 Rubrerythrin - - - 0.0000000000000596 72.0
HKD2_k127_3696200_0 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 424.0
HKD2_k127_3696200_1 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 322.0
HKD2_k127_3696200_2 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 308.0
HKD2_k127_3696200_3 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003205 279.0
HKD2_k127_3696200_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000001287 132.0
HKD2_k127_3696200_5 - - - - 0.0000000000001079 78.0
HKD2_k127_3696200_6 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K20444 - - 0.000000000229 68.0
HKD2_k127_3696200_7 Flp/Fap pilin component K02651 - - 0.0009772 47.0
HKD2_k127_3845240_0 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000005308 198.0
HKD2_k127_3845240_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000005273 166.0
HKD2_k127_3845240_2 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000002597 89.0
HKD2_k127_3852552_0 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000002287 173.0
HKD2_k127_3882793_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 2.782e-283 891.0
HKD2_k127_3882793_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 331.0
HKD2_k127_3882793_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000002784 195.0
HKD2_k127_3882793_3 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.00000000000000000000000000000000000000000000003694 174.0
HKD2_k127_3882793_4 SNARE associated Golgi protein - - - 0.0000000000000000000181 104.0
HKD2_k127_3882793_5 - - - - 0.00000000000003023 75.0
HKD2_k127_3891857_0 PFAM response regulator receiver K11384 - - 3.645e-203 639.0
HKD2_k127_3891857_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11383 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 574.0
HKD2_k127_3930482_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 7.303e-246 779.0
HKD2_k127_3930482_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 350.0
HKD2_k127_3930482_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006315 307.0
HKD2_k127_3930482_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - 0.000000000000000154 89.0
HKD2_k127_3930482_4 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000007618 75.0
HKD2_k127_3930482_5 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000004805 64.0
HKD2_k127_3933679_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1094.0
HKD2_k127_3933679_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.647e-263 827.0
HKD2_k127_3933679_10 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 403.0
HKD2_k127_3933679_11 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 396.0
HKD2_k127_3933679_12 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 420.0
HKD2_k127_3933679_13 AAA domain K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 397.0
HKD2_k127_3933679_14 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 387.0
HKD2_k127_3933679_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 364.0
HKD2_k127_3933679_16 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 357.0
HKD2_k127_3933679_17 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 342.0
HKD2_k127_3933679_18 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 327.0
HKD2_k127_3933679_19 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 329.0
HKD2_k127_3933679_2 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 2.343e-195 643.0
HKD2_k127_3933679_20 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 311.0
HKD2_k127_3933679_21 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 310.0
HKD2_k127_3933679_22 Metal-dependent phosphohydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 317.0
HKD2_k127_3933679_23 PFAM outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006431 316.0
HKD2_k127_3933679_24 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 302.0
HKD2_k127_3933679_25 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 308.0
HKD2_k127_3933679_26 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003591 280.0
HKD2_k127_3933679_27 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008271 298.0
HKD2_k127_3933679_28 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005725 273.0
HKD2_k127_3933679_29 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002348 263.0
HKD2_k127_3933679_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 597.0
HKD2_k127_3933679_30 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000007357 267.0
HKD2_k127_3933679_31 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001092 266.0
HKD2_k127_3933679_32 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001223 273.0
HKD2_k127_3933679_33 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001521 261.0
HKD2_k127_3933679_34 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004764 253.0
HKD2_k127_3933679_35 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000001123 255.0
HKD2_k127_3933679_36 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000001204 236.0
HKD2_k127_3933679_37 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000006124 234.0
HKD2_k127_3933679_38 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000002411 211.0
HKD2_k127_3933679_39 ATP cone domain K07738 - - 0.0000000000000000000000000000000000000000000000000000274 201.0
HKD2_k127_3933679_4 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 599.0
HKD2_k127_3933679_40 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000002799 194.0
HKD2_k127_3933679_41 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000001002 207.0
HKD2_k127_3933679_42 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000004329 183.0
HKD2_k127_3933679_43 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000003049 194.0
HKD2_k127_3933679_44 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000003171 186.0
HKD2_k127_3933679_45 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000005932 186.0
HKD2_k127_3933679_46 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000002731 162.0
HKD2_k127_3933679_47 Domain of unknown function (DUF4416) - - - 0.000000000000000000000000000000000000001502 165.0
HKD2_k127_3933679_48 molybdopterin binding domain - - - 0.000000000000000000000000000000000000002297 156.0
HKD2_k127_3933679_49 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000009514 159.0
HKD2_k127_3933679_5 3,4-dihydroxy-2-butanone 4-phosphate synthase K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 571.0
HKD2_k127_3933679_50 TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family K01808 - 5.3.1.6 0.00000000000000000000000000000000001099 143.0
HKD2_k127_3933679_51 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000217 146.0
HKD2_k127_3933679_52 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000006386 149.0
HKD2_k127_3933679_53 Belongs to the universal stress protein A family - - - 0.000000000000000000000000004076 116.0
HKD2_k127_3933679_54 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000003419 123.0
HKD2_k127_3933679_55 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000001814 105.0
HKD2_k127_3933679_56 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000003411 110.0
HKD2_k127_3933679_57 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000001206 98.0
HKD2_k127_3933679_58 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000003834 103.0
HKD2_k127_3933679_59 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000001135 93.0
HKD2_k127_3933679_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 566.0
HKD2_k127_3933679_60 Protein of unknown function (DUF3108) - - - 0.00000000000000007085 94.0
HKD2_k127_3933679_61 DUF218 domain - - - 0.0000000000000001612 87.0
HKD2_k127_3933679_62 Belongs to the UPF0434 family K09791 - - 0.0000000000000002142 79.0
HKD2_k127_3933679_63 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000008112 78.0
HKD2_k127_3933679_64 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000001192 74.0
HKD2_k127_3933679_65 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000001554 75.0
HKD2_k127_3933679_66 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.0000000001135 74.0
HKD2_k127_3933679_67 outer membrane chaperone Skp (OmpH) K06142 - - 0.00000002541 66.0
HKD2_k127_3933679_68 Lipopolysaccharide-assembly - - - 0.0000001936 63.0
HKD2_k127_3933679_7 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 560.0
HKD2_k127_3933679_70 Domain of unknown function (DUF4388) - - - 0.000005302 58.0
HKD2_k127_3933679_71 Acyl transferase domain in polyketide synthase (PKS) enzymes. K11628,K12431,K12432,K12433,K12437,K12440,K12441,K12442,K12443,K15320,K20422,K21254,K21792 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006725,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009267,GO:0009273,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0016043,GO:0016053,GO:0018958,GO:0019438,GO:0019725,GO:0019751,GO:0019752,GO:0022607,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032787,GO:0032991,GO:0033554,GO:0034081,GO:0034311,GO:0034312,GO:0042546,GO:0042592,GO:0042594,GO:0042844,GO:0042845,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046173,GO:0046189,GO:0046394,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051704,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:0072330,GO:0097040,GO:0097041,GO:0097089,GO:0098771,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1902321 2.3.1.111,2.3.1.165,2.3.1.237,2.3.1.252 0.00001203 57.0
HKD2_k127_3933679_72 Protein of unknown function (DUF3047) - - - 0.0001269 53.0
HKD2_k127_3933679_73 - - - - 0.0006068 47.0
HKD2_k127_3933679_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 511.0
HKD2_k127_3933679_9 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 491.0
HKD2_k127_3959523_0 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000002213 186.0
HKD2_k127_3959523_1 Abc transporter K01996 - - 0.0000000000000000000000000000000000000000000001384 178.0
HKD2_k127_3959523_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000006323 73.0
HKD2_k127_3964803_0 TIGRFAM iron-sulfur cluster binding protein K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 452.0
HKD2_k127_3964803_1 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004423 270.0
HKD2_k127_3964803_2 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.000000000000000000000000000000000000000000004214 165.0
HKD2_k127_4004570_0 Ompa motb domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 323.0
HKD2_k127_4012975_0 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006662 340.0
HKD2_k127_4012975_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 336.0
HKD2_k127_4012975_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000001936 216.0
HKD2_k127_4012975_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000003568 200.0
HKD2_k127_4012975_4 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000001726 199.0
HKD2_k127_4012975_5 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.00000000000000000000000000000000000000000000000000005965 192.0
HKD2_k127_4012975_6 - - - - 0.000000000000000000000000000000001709 133.0
HKD2_k127_4012975_7 Sodium/hydrogen exchanger family - - - 0.00000003088 60.0
HKD2_k127_4028874_0 Large extracellular alpha-helical protein K06894 - - 0.0 2080.0
HKD2_k127_4028874_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 9.33e-321 996.0
HKD2_k127_4028874_10 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000239 115.0
HKD2_k127_4028874_11 3D domain protein - - - 0.0005911 49.0
HKD2_k127_4028874_2 PFAM Polysulphide reductase, NrfD K00185 - - 3.828e-213 668.0
HKD2_k127_4028874_3 penicillin-binding protein K05367 - 2.4.1.129 3.642e-200 690.0
HKD2_k127_4028874_4 PFAM 4Fe-4S K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 492.0
HKD2_k127_4028874_5 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 315.0
HKD2_k127_4028874_6 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000046 250.0
HKD2_k127_4028874_7 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001077 237.0
HKD2_k127_4028874_8 - - - - 0.00000000000000000000000000000000000000004399 159.0
HKD2_k127_4028874_9 Metal-dependent hydrolases of the beta-lactamase superfamily I K00784 - 3.1.26.11 0.000000000000000000000000000000009255 138.0
HKD2_k127_4048123_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 326.0
HKD2_k127_4048123_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002367 265.0
HKD2_k127_4048123_2 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000000169 94.0
HKD2_k127_4118370_0 Polysaccharide biosynthesis protein K17716 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 523.0
HKD2_k127_4118370_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 501.0
HKD2_k127_4118370_10 Glycosyl transferase 4-like domain - - - 0.00006212 48.0
HKD2_k127_4118370_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 456.0
HKD2_k127_4118370_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 389.0
HKD2_k127_4118370_4 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 346.0
HKD2_k127_4118370_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002398 270.0
HKD2_k127_4118370_6 radical SAM domain protein K15045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009974 289.0
HKD2_k127_4118370_7 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002629 245.0
HKD2_k127_4118370_8 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000007305 170.0
HKD2_k127_4196065_0 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 428.0
HKD2_k127_4196065_1 Ribonuclease E/G family K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 383.0
HKD2_k127_4196065_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 344.0
HKD2_k127_4196065_3 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000001607 202.0
HKD2_k127_4196065_4 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000004117 173.0
HKD2_k127_4196065_5 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000875 115.0
HKD2_k127_4196065_6 metalloendopeptidase activity K03799 - - 0.00000000000000000000000001607 121.0
HKD2_k127_4196065_9 - - - - 0.000007489 54.0
HKD2_k127_4235248_0 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 492.0
HKD2_k127_4235248_1 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 443.0
HKD2_k127_4235248_10 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.000000000000000000000000007601 117.0
HKD2_k127_4235248_11 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000000000001809 109.0
HKD2_k127_4235248_12 binding domain protein - GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - 0.00000000000000005034 84.0
HKD2_k127_4235248_13 NifU-like N terminal domain K04488 - - 0.0000000000000009509 90.0
HKD2_k127_4235248_15 Cytochrome c554 and c-prime - - - 0.0000000001929 71.0
HKD2_k127_4235248_16 Rubrerythrin - - - 0.00005876 49.0
HKD2_k127_4235248_2 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 440.0
HKD2_k127_4235248_3 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 329.0
HKD2_k127_4235248_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005361 277.0
HKD2_k127_4235248_5 IMP dehydrogenase activity K04767 - - 0.000000000000000000000000000000000000000000000004044 180.0
HKD2_k127_4235248_6 ACT domain K04767 - - 0.000000000000000000000000000000000007761 144.0
HKD2_k127_4235248_7 Transporter associated domain K03699 - - 0.0000000000000000000000000000000001214 148.0
HKD2_k127_4235248_8 Nitroreductase family - - - 0.0000000000000000000000000000001533 134.0
HKD2_k127_4235248_9 LysM domain - - - 0.0000000000000000000000000003164 134.0
HKD2_k127_4239232_0 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 606.0
HKD2_k127_4239232_1 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 550.0
HKD2_k127_4239232_10 regulatory protein IclR - - - 0.0000000000000000004338 87.0
HKD2_k127_4239232_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 533.0
HKD2_k127_4239232_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 382.0
HKD2_k127_4239232_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 292.0
HKD2_k127_4239232_5 fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001305 285.0
HKD2_k127_4239232_6 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004049 291.0
HKD2_k127_4239232_7 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000001509 121.0
HKD2_k127_4239232_8 SMART Tetratricopeptide - - - 0.0000000000000000000000001049 119.0
HKD2_k127_4239232_9 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000002618 91.0
HKD2_k127_4252420_0 FecR protein - - - 4.221e-291 925.0
HKD2_k127_4252420_1 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 595.0
HKD2_k127_4252420_2 HD domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 379.0
HKD2_k127_4252420_3 TM2 domain - - - 0.0000000000000000000000000001939 119.0
HKD2_k127_4252420_4 gag-polyprotein putative aspartyl protease - - - 0.000000000000000000000000005486 121.0
HKD2_k127_4252420_5 Sel1-like repeats. K07126 - - 0.00000000000000000007599 94.0
HKD2_k127_426387_0 elongation factor Tu domain 2 protein K02355,K18220 - - 2.742e-201 651.0
HKD2_k127_426387_1 Collagenase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 335.0
HKD2_k127_426387_2 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000002144 191.0
HKD2_k127_4294744_0 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000003799 250.0
HKD2_k127_4294744_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001648 242.0
HKD2_k127_4294744_2 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000008601 202.0
HKD2_k127_4294744_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000009514 187.0
HKD2_k127_4294744_4 - - - - 0.0000000000000000000000000000000000000000001484 179.0
HKD2_k127_4294744_5 Lipid A 3-O-deacylase (PagL) - - - 0.0000000000000000000000000000004543 126.0
HKD2_k127_4294744_6 peroxiredoxin activity - - - 0.0000000000000000001472 102.0
HKD2_k127_4294744_7 Dodecin K09165 - - 0.0000000000000000001912 95.0
HKD2_k127_4294744_8 - - - - 0.000000000000003107 87.0
HKD2_k127_4361707_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 499.0
HKD2_k127_4361707_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002208 292.0
HKD2_k127_4361707_2 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001151 278.0
HKD2_k127_4361707_3 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000159 274.0
HKD2_k127_4361707_4 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009065 255.0
HKD2_k127_4361707_5 GTP-binding protein TypA K06207 - - 0.00000000000000000000000000000000000000000000000000000000000000000001799 235.0
HKD2_k127_4363448_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.271e-230 727.0
HKD2_k127_4363448_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 326.0
HKD2_k127_4391223_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 458.0
HKD2_k127_4391223_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 446.0
HKD2_k127_4391223_10 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000001254 148.0
HKD2_k127_4391223_11 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000001784 115.0
HKD2_k127_4391223_12 Transcriptional regulator - - - 0.0000000000000000000001208 103.0
HKD2_k127_4391223_13 Thioesterase K01075 - 3.1.2.23 0.000000000000000004838 97.0
HKD2_k127_4391223_14 Belongs to the sulfur carrier protein TusA family - - - 0.0000000002886 63.0
HKD2_k127_4391223_15 - K07245 - - 0.000000686 59.0
HKD2_k127_4391223_2 PFAM Cys Met metabolism K01739,K01760 - 2.5.1.48,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 423.0
HKD2_k127_4391223_3 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 302.0
HKD2_k127_4391223_4 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 302.0
HKD2_k127_4391223_5 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 292.0
HKD2_k127_4391223_6 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009149 288.0
HKD2_k127_4391223_7 penicillin-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000795 277.0
HKD2_k127_4391223_8 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001075 260.0
HKD2_k127_4391223_9 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000005095 203.0
HKD2_k127_44318_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004655 267.0
HKD2_k127_44318_1 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000007179 192.0
HKD2_k127_44318_2 Domain of unknown function K00560 GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046073,GO:0046385,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.0000000000000000000000005656 119.0
HKD2_k127_44318_3 Domain of unknown function (DUF4445) - - - 0.0000005972 53.0
HKD2_k127_4485839_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 1.098e-251 790.0
HKD2_k127_4489664_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 466.0
HKD2_k127_4489664_1 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 440.0
HKD2_k127_4489664_10 NUDIX domain - - - 0.000000000000000000000000000000000000000000003853 169.0
HKD2_k127_4489664_11 cyclic diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000004182 188.0
HKD2_k127_4489664_12 Domain of unknown function (DUF296) - - - 0.0000000000000000000000000000005878 134.0
HKD2_k127_4489664_13 PBS lyase HEAT-like repeat - - - 0.000000000001881 81.0
HKD2_k127_4489664_2 Belongs to the DegT DnrJ EryC1 family K07806 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 390.0
HKD2_k127_4489664_3 PFAM glycosyl transferase family 39 K07264 - 2.4.2.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 363.0
HKD2_k127_4489664_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 351.0
HKD2_k127_4489664_5 Formyl transferase, C-terminal domain K10011,K12449 - 1.1.1.305,2.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 320.0
HKD2_k127_4489664_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 329.0
HKD2_k127_4489664_7 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005288 297.0
HKD2_k127_4489664_8 Cytochrome P460 - - - 0.000000000000000000000000000000000000000000000000000000006925 203.0
HKD2_k127_4489664_9 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000001212 207.0
HKD2_k127_4508533_0 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 384.0
HKD2_k127_4508533_1 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 382.0
HKD2_k127_4508533_2 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001856 287.0
HKD2_k127_4508533_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000001453 255.0
HKD2_k127_4508533_4 N-terminal domain of unknown function (DUF4140) - - - 0.000000000000000000000000000000000000000000000005079 196.0
HKD2_k127_4508533_5 peptidase M29 K19689 - - 0.0000000000000003628 83.0
HKD2_k127_4508533_6 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000007909 69.0
HKD2_k127_4508533_7 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00001608 50.0
HKD2_k127_4508533_8 Protein of unknown function (DUF2889) - - - 0.00002699 54.0
HKD2_k127_4509011_0 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 434.0
HKD2_k127_4509011_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 398.0
HKD2_k127_4509011_10 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000004047 97.0
HKD2_k127_4509011_11 nucleic-acid-binding protein implicated in transcription termination K07742 - - 0.000002763 57.0
HKD2_k127_4509011_12 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000004607 55.0
HKD2_k127_4509011_2 Catalyzes the conversion of dihydroorotate to orotate K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 362.0
HKD2_k127_4509011_3 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001343 263.0
HKD2_k127_4509011_4 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000003543 268.0
HKD2_k127_4509011_5 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001897 249.0
HKD2_k127_4509011_6 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000000000000000000000000000000005625 179.0
HKD2_k127_4509011_7 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000007313 164.0
HKD2_k127_4509011_8 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000002372 149.0
HKD2_k127_4509011_9 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000001305 123.0
HKD2_k127_4514711_0 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000001714 202.0
HKD2_k127_4516282_0 belongs to the aldehyde dehydrogenase family K00128,K00131,K00135,K00140 - 1.2.1.16,1.2.1.18,1.2.1.20,1.2.1.27,1.2.1.3,1.2.1.79,1.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 545.0
HKD2_k127_4516282_1 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 327.0
HKD2_k127_4516282_2 peptidase M29 aminopeptidase II K19689 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002599 282.0
HKD2_k127_4516282_3 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.000000000000000000000000000000000004555 158.0
HKD2_k127_4517978_0 Glycosyltransferase family 20 K16055 - 2.4.1.15,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 527.0
HKD2_k127_4517978_1 PDZ domain (Also known as DHR or GLGF) K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 527.0
HKD2_k127_4517978_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000005814 118.0
HKD2_k127_4517978_11 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000004376 109.0
HKD2_k127_4517978_12 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.000000000000000000000003284 111.0
HKD2_k127_4517978_14 redox-active disulfide protein 2 - - - 0.00000003652 55.0
HKD2_k127_4517978_15 Bacterial protein of unknown function (DUF853) K06915 - - 0.00001506 49.0
HKD2_k127_4517978_2 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 526.0
HKD2_k127_4517978_3 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 477.0
HKD2_k127_4517978_4 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 334.0
HKD2_k127_4517978_5 L,D-transpeptidase catalytic domain K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006103 276.0
HKD2_k127_4517978_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000001016 190.0
HKD2_k127_4517978_7 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000009491 171.0
HKD2_k127_4517978_8 trehalose biosynthetic process K01087 - 3.1.3.12 0.00000000000000000000000000000000008194 154.0
HKD2_k127_4517978_9 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000061 138.0
HKD2_k127_4531062_0 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 593.0
HKD2_k127_4531062_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000002203 154.0
HKD2_k127_4531062_2 PFAM LmbE family protein K18455 - 3.5.1.115 0.000000000000000000000000000000000002966 146.0
HKD2_k127_4531062_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00001072 57.0
HKD2_k127_4539702_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 526.0
HKD2_k127_4539702_1 GAF domain K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 439.0
HKD2_k127_4539702_2 Predicted periplasmic lipoprotein (DUF2279) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001609 268.0
HKD2_k127_4539702_3 regulation of single-species biofilm formation K02342,K03763,K13573 - 2.7.7.7 0.0000000000000000000000000002838 123.0
HKD2_k127_4539702_4 Rubrerythrin - - - 0.000000000000001242 76.0
HKD2_k127_45822_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.919e-203 657.0
HKD2_k127_45822_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 592.0
HKD2_k127_45822_10 Domain of unknown function (DUF4124) K08309 - - 0.000000000000000000000000000000000000000000000001003 181.0
HKD2_k127_45822_11 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000002384 160.0
HKD2_k127_45822_12 diguanylate cyclase - - - 0.00000000000000000000000000000000001699 152.0
HKD2_k127_45822_13 - - - - 0.0000000000009008 77.0
HKD2_k127_45822_14 - - - - 0.0001568 48.0
HKD2_k127_45822_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 510.0
HKD2_k127_45822_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 448.0
HKD2_k127_45822_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 411.0
HKD2_k127_45822_5 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 401.0
HKD2_k127_45822_6 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
HKD2_k127_45822_7 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 306.0
HKD2_k127_45822_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000006613 213.0
HKD2_k127_45822_9 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000001942 190.0
HKD2_k127_4652743_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 530.0
HKD2_k127_4652743_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 293.0
HKD2_k127_4652743_2 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005581 280.0
HKD2_k127_4652743_3 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001773 287.0
HKD2_k127_4652743_4 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000154 265.0
HKD2_k127_4652743_5 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000001561 245.0
HKD2_k127_4663091_0 Transketolase, thiamine diphosphate binding domain K01662 - 2.2.1.7 1.053e-280 891.0
HKD2_k127_4663091_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 541.0
HKD2_k127_4663091_10 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 338.0
HKD2_k127_4663091_11 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 317.0
HKD2_k127_4663091_12 SNARE associated Golgi protein K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 293.0
HKD2_k127_4663091_13 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001237 258.0
HKD2_k127_4663091_14 Butirosin biosynthesis protein H, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000005742 237.0
HKD2_k127_4663091_15 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.00000000000000000000000000000000000000000000000001076 194.0
HKD2_k127_4663091_16 PFAM Haloacid dehalogenase domain protein hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000001127 198.0
HKD2_k127_4663091_17 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000001009 156.0
HKD2_k127_4663091_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000002739 144.0
HKD2_k127_4663091_19 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.00000000000000000000000000000000004435 142.0
HKD2_k127_4663091_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 485.0
HKD2_k127_4663091_20 CAAX protease self-immunity K07052 - - 0.000000000002257 75.0
HKD2_k127_4663091_21 PFAM extracellular solute-binding protein, family 5 K02035,K13893 - - 0.00000000000833 76.0
HKD2_k127_4663091_3 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 462.0
HKD2_k127_4663091_4 NmrA-like family K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 451.0
HKD2_k127_4663091_5 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 395.0
HKD2_k127_4663091_6 Domain of unknown function (DUF3463) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 382.0
HKD2_k127_4663091_7 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 355.0
HKD2_k127_4663091_8 Aminotransferase class I and II K00639,K00652 - 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 365.0
HKD2_k127_4663091_9 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 344.0
HKD2_k127_4692810_0 aconitate hydratase K01681 - 4.2.1.3 1.63e-238 752.0
HKD2_k127_4692810_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 484.0
HKD2_k127_4692810_2 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 347.0
HKD2_k127_4692810_3 PFAM OmpA MotB domain protein K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000122 248.0
HKD2_k127_4692810_4 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000001988 232.0
HKD2_k127_4692810_5 - - - - 0.000000000000000000004305 94.0
HKD2_k127_4722365_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.041e-208 659.0
HKD2_k127_4722365_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000276 288.0
HKD2_k127_4722365_2 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000002569 259.0
HKD2_k127_4722365_3 extracellular solute-binding protein, family 5 K02035,K15584 - - 0.0000000000000000000000000000000000000000000000001492 184.0
HKD2_k127_4722365_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000002482 194.0
HKD2_k127_4722365_5 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.000000000000000000000000000000000000000003845 169.0
HKD2_k127_473659_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 539.0
HKD2_k127_473659_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 428.0
HKD2_k127_473659_2 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 383.0
HKD2_k127_473659_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 321.0
HKD2_k127_473659_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001789 287.0
HKD2_k127_473659_5 Sensor histidine kinase PilS, PAS domain-containing K02668,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001439 274.0
HKD2_k127_473659_6 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001265 266.0
HKD2_k127_473659_7 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000006725 238.0
HKD2_k127_4737650_0 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 366.0
HKD2_k127_4737650_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 316.0
HKD2_k127_4737650_2 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000001457 226.0
HKD2_k127_4737650_3 Propionate catabolism operon regulatory protein K02688 - - 0.000005128 56.0
HKD2_k127_4751489_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1339.0
HKD2_k127_4751489_1 Belongs to the peptidase M16 family K07263 - - 5.286e-200 654.0
HKD2_k127_4751489_2 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 492.0
HKD2_k127_4751489_3 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000004983 226.0
HKD2_k127_4751489_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000001942 215.0
HKD2_k127_4777454_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 615.0
HKD2_k127_4777454_1 Mycolic acid cyclopropane synthetase K00574,K20238 - 2.1.1.317,2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006025 488.0
HKD2_k127_4777454_2 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000001907 146.0
HKD2_k127_4907812_0 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 449.0
HKD2_k127_4907812_1 PFAM Metallophosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 342.0
HKD2_k127_4907812_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002796 284.0
HKD2_k127_4907812_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000585 172.0
HKD2_k127_4907812_4 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000000000000000000001644 154.0
HKD2_k127_4907812_5 Universal stress protein - - - 0.000000000000000000000000000000000001561 144.0
HKD2_k127_4907812_6 Tetratricopeptide repeats - - - 0.00000000000004228 82.0
HKD2_k127_5055723_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 535.0
HKD2_k127_5055723_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 462.0
HKD2_k127_5055723_10 Belongs to the acetyltransferase family. ArgA subfamily K00619 - 2.3.1.1 0.00000000000000000008522 104.0
HKD2_k127_5055723_11 - - - - 0.0000002242 58.0
HKD2_k127_5055723_2 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 463.0
HKD2_k127_5055723_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 417.0
HKD2_k127_5055723_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 355.0
HKD2_k127_5055723_5 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 358.0
HKD2_k127_5055723_6 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 330.0
HKD2_k127_5055723_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001215 293.0
HKD2_k127_5055723_8 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006363 266.0
HKD2_k127_5055723_9 Domain of unknown function (DUF4153) - - - 0.00000000000000000000000000000000000000000000003306 196.0
HKD2_k127_5070769_0 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 432.0
HKD2_k127_5070769_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004456 328.0
HKD2_k127_5070769_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004398 289.0
HKD2_k127_5070769_3 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006567 284.0
HKD2_k127_5070769_4 Transcriptional regulatory protein, C terminal K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000006023 230.0
HKD2_k127_5070769_5 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000001839 161.0
HKD2_k127_5070769_6 inorganic phosphate transmembrane transporter activity K02037,K02038 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.00000000000000000000000000000000000008406 159.0
HKD2_k127_5070769_7 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000003669 105.0
HKD2_k127_5199768_0 PFAM AAA ATPase central domain protein K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 466.0
HKD2_k127_5199768_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000643 313.0
HKD2_k127_5199768_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 312.0
HKD2_k127_5199768_3 Peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000006169 248.0
HKD2_k127_5199768_4 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000001897 211.0
HKD2_k127_52122_0 Amino acid permease - - - 1.181e-203 655.0
HKD2_k127_52122_1 Molybdenum Cofactor Synthesis C K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 308.0
HKD2_k127_52122_10 Cytochrome c554 and c-prime - - - 0.0000000000000000005243 94.0
HKD2_k127_52122_11 - - - - 0.0000000000002658 76.0
HKD2_k127_52122_2 SMART Elongator protein 3 MiaB NifB K07139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003705 274.0
HKD2_k127_52122_3 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000028 219.0
HKD2_k127_52122_4 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000009667 209.0
HKD2_k127_52122_5 Glycosyl transferase, family 9 K02841,K02843,K02847,K02849,K21003 - - 0.000000000000000000000000000000000000000000502 182.0
HKD2_k127_52122_6 phosphinothricin N-acetyltransferase activity - - - 0.0000000000000000000000000000000000000000008473 165.0
HKD2_k127_52122_7 Thioesterase superfamily - - - 0.00000000000000000000000000000002045 134.0
HKD2_k127_52122_8 Papain-like cysteine protease AvrRpt2 - - - 0.00000000000000000000001413 113.0
HKD2_k127_52122_9 Tetratricopeptide repeat - - - 0.00000000000000000001916 104.0
HKD2_k127_5217043_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 522.0
HKD2_k127_5217043_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 472.0
HKD2_k127_5217043_2 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 444.0
HKD2_k127_5217043_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 377.0
HKD2_k127_5217043_4 TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 309.0
HKD2_k127_5271894_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 563.0
HKD2_k127_5271894_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 566.0
HKD2_k127_5271894_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000003281 92.0
HKD2_k127_5271894_3 protein involved in outer membrane biogenesis K07289 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.0000000216 67.0
HKD2_k127_5375829_0 chlorophyll binding K03286,K03640 - - 0.000000000000000000000000000000000000000000000000000000002706 214.0
HKD2_k127_5375829_1 - - - - 0.000000000000000000000000555 109.0
HKD2_k127_5404170_0 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 376.0
HKD2_k127_5404170_1 Sulfatase K19353 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 366.0
HKD2_k127_5404170_2 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 316.0
HKD2_k127_5404170_4 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000005928 91.0
HKD2_k127_5410645_0 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000007872 237.0
HKD2_k127_5410645_2 PD-(D/E)XK nuclease superfamily - - - 0.0005172 52.0
HKD2_k127_5421740_0 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 4.384e-200 631.0
HKD2_k127_5421740_1 Heavy metal translocating P-type atpase K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 534.0
HKD2_k127_5421740_10 2-Nitropropane dioxygenase - - - 0.00000000000000007629 96.0
HKD2_k127_5421740_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 516.0
HKD2_k127_5421740_3 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 389.0
HKD2_k127_5421740_4 isomerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 314.0
HKD2_k127_5421740_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 295.0
HKD2_k127_5421740_6 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000001463 222.0
HKD2_k127_5421740_7 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000007551 216.0
HKD2_k127_5421740_8 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000006106 135.0
HKD2_k127_5421740_9 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000005169 117.0
HKD2_k127_5460369_0 C4-dicarboxylate transmembrane transporter activity K07791,K07792 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 514.0
HKD2_k127_5460369_1 Amino acid ABC transporter substrate-binding protein K10039 - - 0.00000000000000000000000000000000000000000000001437 181.0
HKD2_k127_5460369_2 Aspartate ammonia-lyase K01744 - 4.3.1.1 0.0000000000000000000000000000000007533 142.0
HKD2_k127_5479555_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 4.047e-247 784.0
HKD2_k127_5479555_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 604.0
HKD2_k127_5479555_10 ADP-ribosylglycohydrolase - - - 0.0000000000005247 82.0
HKD2_k127_5479555_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 553.0
HKD2_k127_5479555_3 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 479.0
HKD2_k127_5479555_4 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 460.0
HKD2_k127_5479555_5 regulatory protein IclR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 311.0
HKD2_k127_5479555_6 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000002644 246.0
HKD2_k127_5479555_7 PFAM regulatory protein TetR K13770 - - 0.00000000000000000000000000000000000000000000000000001107 196.0
HKD2_k127_5479555_8 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000001062 194.0
HKD2_k127_5479555_9 Biotin-requiring enzyme - - - 0.00000000000000000000000000001359 123.0
HKD2_k127_557898_0 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 5.293e-261 826.0
HKD2_k127_557898_1 histidine kinase HAMP region domain protein K03406 - - 0.0000000000000000000000000000000000000000000000000005219 194.0
HKD2_k127_557898_2 PFAM response regulator receiver K03413 - - 0.00000000000000000000000000000000000000000000000002615 188.0
HKD2_k127_557898_3 STAS domain - - - 0.0000000000001247 76.0
HKD2_k127_5582482_0 Translation-initiation factor 2 K02519 - - 1.875e-232 733.0
HKD2_k127_5582482_1 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 4.527e-197 630.0
HKD2_k127_5582482_2 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 302.0
HKD2_k127_5582482_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000001386 222.0
HKD2_k127_5582482_4 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000006509 132.0
HKD2_k127_5582482_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000007525 115.0
HKD2_k127_5582482_6 Protein of unknown function (DUF503) K09764 - - 0.000000000001 74.0
HKD2_k127_5664573_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 578.0
HKD2_k127_5664573_1 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 500.0
HKD2_k127_5664573_10 Cell wall formation K00075 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 0.00000000000000000000000000000000000000000000000000000002597 208.0
HKD2_k127_5664573_11 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000000000002096 161.0
HKD2_k127_5664573_12 Reverse transcriptase-like K03469,K06864,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.00000000000000000000000000000001987 142.0
HKD2_k127_5664573_13 Psort location Cytoplasmic, score 8.87 K03925 - - 0.00000000000000000000000000000006598 129.0
HKD2_k127_5664573_15 cell division protein FtsL - - - 0.0001678 53.0
HKD2_k127_5664573_2 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 514.0
HKD2_k127_5664573_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 407.0
HKD2_k127_5664573_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 362.0
HKD2_k127_5664573_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006906 325.0
HKD2_k127_5664573_6 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006836 320.0
HKD2_k127_5664573_7 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001634 278.0
HKD2_k127_5664573_8 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000245 230.0
HKD2_k127_5664573_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000005061 227.0
HKD2_k127_5672463_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 447.0
HKD2_k127_5672463_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 396.0
HKD2_k127_5672463_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 390.0
HKD2_k127_5672463_3 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 381.0
HKD2_k127_5683504_0 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 466.0
HKD2_k127_5683504_1 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 377.0
HKD2_k127_5683504_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001715 261.0
HKD2_k127_5683504_3 glutamate synthase (NADPH) K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000006441 149.0
HKD2_k127_5683504_4 - - - - 0.000000000000000000000000004667 113.0
HKD2_k127_5683504_5 Peptidase family M23 K21471 - - 0.00000000000000008198 93.0
HKD2_k127_5683504_6 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.0000000000002571 80.0
HKD2_k127_5683504_7 Divergent polysaccharide deacetylase K09798 - - 0.0000000009958 71.0
HKD2_k127_5697375_0 Metal-dependent phosphohydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002117 282.0
HKD2_k127_5697375_1 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000003473 225.0
HKD2_k127_5697375_2 SMART metal-dependent phosphohydrolase, HD K07037 - - 0.0003849 51.0
HKD2_k127_5709956_0 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 321.0
HKD2_k127_5709956_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 312.0
HKD2_k127_5709956_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000003555 170.0
HKD2_k127_5709956_3 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000002195 132.0
HKD2_k127_5709956_4 GGDEF domain K02488 - 2.7.7.65 0.0000000000000000000000000007728 124.0
HKD2_k127_5709956_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000001095 78.0
HKD2_k127_5734738_0 L-glutamate biosynthetic process K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1995.0
HKD2_k127_5734738_1 alpha beta alpha domain I K01835 - 5.4.2.2 1.693e-257 803.0
HKD2_k127_5734738_10 LUD domain K00782 - - 0.000000000000000000000000000000000002173 158.0
HKD2_k127_5734738_11 - - - - 0.0000000000000000000000000000000006175 139.0
HKD2_k127_5734738_12 Belongs to the bacterial solute-binding protein 3 family K02030,K10001 - - 0.00000000000000000000000003013 109.0
HKD2_k127_5734738_2 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007117 535.0
HKD2_k127_5734738_3 glutamate synthase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 529.0
HKD2_k127_5734738_4 Pfam:DUF162 K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 528.0
HKD2_k127_5734738_5 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 452.0
HKD2_k127_5734738_6 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 366.0
HKD2_k127_5734738_7 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 330.0
HKD2_k127_5734738_8 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 334.0
HKD2_k127_5734738_9 homolog of gamma-carboxymuconolactone decarboxylase subunit K01607 - 4.1.1.44 0.000000000000000000000000000000000000001659 152.0
HKD2_k127_5736285_0 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 494.0
HKD2_k127_5736285_1 Proposed homoserine kinase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 468.0
HKD2_k127_5736285_2 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008305 414.0
HKD2_k127_5736285_3 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 342.0
HKD2_k127_5736285_4 PFAM thioesterase superfamily protein K07107 - - 0.000000000000000000000000002423 118.0
HKD2_k127_5736285_5 4 iron, 4 sulfur cluster binding K00176 - 1.2.7.3 0.0000000000000000000477 95.0
HKD2_k127_5745740_0 ATP-dependent helicase HrpB K03579 - 3.6.4.13 1.157e-318 1006.0
HKD2_k127_5745740_1 - - - - 2.614e-236 751.0
HKD2_k127_5745740_2 Domain of unknown function (DUF4070) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 513.0
HKD2_k127_5745740_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 363.0
HKD2_k127_5745740_4 - - - - 0.0002172 51.0
HKD2_k127_5867652_0 Cytochrome c - - - 0.0000000000000000000000000000000003533 148.0
HKD2_k127_5867652_1 Cytochrome c mono- and diheme variants - - - 0.00000000000000000000000000000004092 141.0
HKD2_k127_5867652_2 aminotransferase K00817 - 2.6.1.9 0.0000001271 55.0
HKD2_k127_5925524_0 Natural resistance-associated macrophage protein K03322 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 592.0
HKD2_k127_5925524_1 Sigma-54 interaction domain K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 445.0
HKD2_k127_5925524_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 295.0
HKD2_k127_5925524_3 Domains HisKA, HATPase_c - - - 0.00000000000000000000000000000000000000000000000000000000000000000004156 250.0
HKD2_k127_5925524_4 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000005061 216.0
HKD2_k127_5925524_5 PFAM Uncharacterised protein family UPF0150 - - - 0.0002688 48.0
HKD2_k127_5925524_6 DsrE/DsrF-like family - - - 0.0007889 49.0
HKD2_k127_5944294_0 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 490.0
HKD2_k127_5944294_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001433 279.0
HKD2_k127_5944294_2 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000001254 255.0
HKD2_k127_5951081_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 1.598e-197 653.0
HKD2_k127_5951081_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 593.0
HKD2_k127_5951081_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000132 63.0
HKD2_k127_5951081_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000003676 63.0
HKD2_k127_5951081_2 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009582 282.0
HKD2_k127_5951081_3 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.0000000000000000000000000000000000000000000000000001846 206.0
HKD2_k127_5951081_4 Putative molybdenum carrier - - - 0.0000000000000000000000000000000000000000000000003268 180.0
HKD2_k127_5951081_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000862 179.0
HKD2_k127_5951081_6 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000007304 151.0
HKD2_k127_5951081_7 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000002633 141.0
HKD2_k127_5951081_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000001075 123.0
HKD2_k127_5951081_9 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000000003562 80.0
HKD2_k127_5971845_0 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 533.0
HKD2_k127_5971845_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 327.0
HKD2_k127_5971845_10 HEAT repeat - - - 0.000000000000000000000000007107 127.0
HKD2_k127_5971845_11 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000005155 113.0
HKD2_k127_5971845_12 PFAM Methyltransferase type 11 - - - 0.000000000000000004401 98.0
HKD2_k127_5971845_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000212 241.0
HKD2_k127_5971845_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000004979 228.0
HKD2_k127_5971845_4 Protein of unknown function (DUF1698) - - - 0.00000000000000000000000000000000000000000000000000001277 201.0
HKD2_k127_5971845_5 Predicted permease - - - 0.000000000000000000000000000000000000000000000001266 186.0
HKD2_k127_5971845_6 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000004596 175.0
HKD2_k127_5971845_7 - - - - 0.00000000000000000000000000000000000000001209 168.0
HKD2_k127_5971845_8 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000004585 170.0
HKD2_k127_5971845_9 peroxiredoxin activity - - - 0.00000000000000000000000000000000003468 141.0
HKD2_k127_6008124_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.609e-200 676.0
HKD2_k127_6008124_1 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009896 472.0
HKD2_k127_6008124_10 Glutaredoxin K03676 - - 0.00000001004 57.0
HKD2_k127_6008124_11 Rubrerythrin - - - 0.0000191 54.0
HKD2_k127_6008124_2 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 434.0
HKD2_k127_6008124_3 Collagenase K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 355.0
HKD2_k127_6008124_4 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000003968 249.0
HKD2_k127_6008124_5 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000008755 239.0
HKD2_k127_6008124_6 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000004328 199.0
HKD2_k127_6008124_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000002789 177.0
HKD2_k127_6008124_8 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000006745 139.0
HKD2_k127_6008124_9 PFAM thioesterase superfamily K02614 - - 0.000000000000195 78.0
HKD2_k127_6039076_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1722.0
HKD2_k127_6039076_1 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 598.0
HKD2_k127_6039076_10 PFAM regulatory protein TetR K16137 - - 0.00000000000000000000000000000000000000000000000000000000000103 223.0
HKD2_k127_6039076_11 - - - - 0.000000000000000000000000000000000000000000000000000002579 194.0
HKD2_k127_6039076_12 - - - - 0.000000000000000000000000000000000000000000000000000007826 194.0
HKD2_k127_6039076_13 translation initiation factor activity K03646 - - 0.000000000000000000000000000000000000008155 149.0
HKD2_k127_6039076_14 TIGRFAM redox-active disulfide protein 2 - - - 0.00000000000003941 74.0
HKD2_k127_6039076_15 - - - - 0.00000000000003973 78.0
HKD2_k127_6039076_16 MaoC like domain - - - 0.0003798 44.0
HKD2_k127_6039076_2 PLD-like domain K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 565.0
HKD2_k127_6039076_3 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 451.0
HKD2_k127_6039076_4 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 487.0
HKD2_k127_6039076_5 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 394.0
HKD2_k127_6039076_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 383.0
HKD2_k127_6039076_7 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007512 344.0
HKD2_k127_6039076_8 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 339.0
HKD2_k127_6039076_9 Belongs to the enoyl-CoA hydratase isomerase family K01715,K13766 - 4.2.1.17,4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 304.0
HKD2_k127_6039787_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.866e-221 730.0
HKD2_k127_6039787_1 CoA binding domain K01905,K22224 - 6.2.1.13 1.046e-196 633.0
HKD2_k127_6039787_10 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.0000000000000008113 77.0
HKD2_k127_6039787_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 443.0
HKD2_k127_6039787_3 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 341.0
HKD2_k127_6039787_4 PFAM Silent information regulator protein Sir2 K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000031 258.0
HKD2_k127_6039787_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000001096 214.0
HKD2_k127_6039787_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000000003892 167.0
HKD2_k127_6039787_7 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000002184 165.0
HKD2_k127_6039787_8 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000003997 105.0
HKD2_k127_6039787_9 SCP-2 sterol transfer family - - - 0.00000000000000000000002467 103.0
HKD2_k127_606522_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 545.0
HKD2_k127_606522_1 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008105 467.0
HKD2_k127_606522_10 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000005675 217.0
HKD2_k127_606522_11 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000724 210.0
HKD2_k127_606522_12 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000002596 183.0
HKD2_k127_606522_13 - - - - 0.0000000000000000000000000000000000000000000003079 189.0
HKD2_k127_606522_14 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000001519 166.0
HKD2_k127_606522_15 MaoC like domain - - - 0.0000000000000000000000000000000000000001429 157.0
HKD2_k127_606522_16 Essential cell division protein K03589 - - 0.00000000000000000000000000000002178 136.0
HKD2_k127_606522_17 YGGT family K02221 - - 0.000000000000000000000000007213 114.0
HKD2_k127_606522_18 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000001186 97.0
HKD2_k127_606522_19 DUF167 K09131 - - 0.00000000000000001026 91.0
HKD2_k127_606522_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 439.0
HKD2_k127_606522_20 PFAM Colicin V production protein K03558 - - 0.0000008759 59.0
HKD2_k127_606522_21 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00001012 54.0
HKD2_k127_606522_23 PAS fold - - - 0.0002145 49.0
HKD2_k127_606522_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 438.0
HKD2_k127_606522_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 415.0
HKD2_k127_606522_5 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 369.0
HKD2_k127_606522_6 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001721 275.0
HKD2_k127_606522_7 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000005457 259.0
HKD2_k127_606522_8 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000005824 248.0
HKD2_k127_606522_9 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000005457 230.0
HKD2_k127_6124971_0 AsmA-like C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 507.0
HKD2_k127_6124971_1 Belongs to the bacterial solute-binding protein 3 family K02030,K10001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007636 259.0
HKD2_k127_6124971_2 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000208 252.0
HKD2_k127_6124971_3 - - - - 0.000006607 56.0
HKD2_k127_6140882_0 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 424.0
HKD2_k127_6140882_1 Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003853 304.0
HKD2_k127_6140882_2 - - - - 0.000000000000000000000000000000000000000000000000007414 191.0
HKD2_k127_6140882_3 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000000000352 173.0
HKD2_k127_6158799_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1106.0
HKD2_k127_6158799_1 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 498.0
HKD2_k127_6158799_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 309.0
HKD2_k127_6158799_3 Domain of unknown function (DUF4118) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001154 265.0
HKD2_k127_6158799_4 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042,K18121 - 1.1.1.31,1.1.1.60,1.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000002491 252.0
HKD2_k127_6158799_5 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000003616 190.0
HKD2_k127_6158799_6 Crp Fnr family K21563 - - 0.0000000000000000000000000000000000000000000000002222 184.0
HKD2_k127_6158799_7 ACT domain K03567 - - 0.0000000000000000000000000000000000000000000000005455 182.0
HKD2_k127_6158799_8 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000002024 146.0
HKD2_k127_6158799_9 - - - - 0.00000000000000226 78.0
HKD2_k127_6394057_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1129.0
HKD2_k127_6394057_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 619.0
HKD2_k127_6394057_10 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000001011 107.0
HKD2_k127_6394057_11 Helix-turn-helix domain - - - 0.0000000000000000001106 99.0
HKD2_k127_6394057_12 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000005941 96.0
HKD2_k127_6394057_13 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000005126 52.0
HKD2_k127_6394057_2 Domain of unknown function (DUF3552) K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 609.0
HKD2_k127_6394057_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 623.0
HKD2_k127_6394057_4 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 524.0
HKD2_k127_6394057_5 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 485.0
HKD2_k127_6394057_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 327.0
HKD2_k127_6394057_7 Na phosphate symporter K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005254 296.0
HKD2_k127_6394057_8 PFAM Metallophosphoesterase K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006443 285.0
HKD2_k127_6394057_9 phosphoenolpyruvate-protein phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000005583 179.0
HKD2_k127_6401211_0 Endopeptidase La K04076 - 3.4.21.53 7.442e-232 743.0
HKD2_k127_6401211_1 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 446.0
HKD2_k127_6401211_10 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000000002022 112.0
HKD2_k127_6401211_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 428.0
HKD2_k127_6401211_3 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009595 423.0
HKD2_k127_6401211_4 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 413.0
HKD2_k127_6401211_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 389.0
HKD2_k127_6401211_6 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 371.0
HKD2_k127_6401211_7 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 358.0
HKD2_k127_6401211_8 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 344.0
HKD2_k127_6401211_9 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000004942 141.0
HKD2_k127_6424085_0 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 491.0
HKD2_k127_6424085_1 nucleic acid binding K03698 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 304.0
HKD2_k127_6424085_2 5-formyltetrahydrofolate cyclo-ligase activity K07137 - - 0.0000000001381 62.0
HKD2_k127_6430404_0 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007117 272.0
HKD2_k127_6430404_1 (2R)-phospho-3-sulfolactate synthase (ComA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003536 254.0
HKD2_k127_6430404_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000002805 194.0
HKD2_k127_6430404_3 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000000000000000001192 121.0
HKD2_k127_6454591_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000000001102 105.0
HKD2_k127_6454591_1 - - - - 0.00000006147 61.0
HKD2_k127_6454591_2 Saccharopine dehydrogenase K12445 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030312,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0001134 54.0
HKD2_k127_6466222_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009795 452.0
HKD2_k127_6466222_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000007851 180.0
HKD2_k127_6466222_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000002248 143.0
HKD2_k127_6466222_3 Protein of unknown function (DUF2905) - - - 0.0000000000000005319 87.0
HKD2_k127_6466222_4 Methyltransferase domain - - - 0.0000000001017 64.0
HKD2_k127_6549500_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1202.0
HKD2_k127_6549500_1 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 497.0
HKD2_k127_6549500_10 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000001471 168.0
HKD2_k127_6549500_11 PFAM CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000006112 149.0
HKD2_k127_6549500_12 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000003263 138.0
HKD2_k127_6549500_13 WD40 repeat-like protein - - - 0.000000000000000000000000000002331 138.0
HKD2_k127_6549500_2 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 460.0
HKD2_k127_6549500_3 FAD-dependent dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 410.0
HKD2_k127_6549500_4 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 331.0
HKD2_k127_6549500_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 327.0
HKD2_k127_6549500_6 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001093 237.0
HKD2_k127_6549500_7 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000002088 212.0
HKD2_k127_6549500_8 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000003645 171.0
HKD2_k127_6549500_9 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.000000000000000000000000000000000000000002251 169.0
HKD2_k127_6572282_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.546e-310 976.0
HKD2_k127_6572282_1 SMART helicase c2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 491.0
HKD2_k127_6572282_10 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000003604 193.0
HKD2_k127_6572282_11 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000000000000000000002377 154.0
HKD2_k127_6572282_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000003742 69.0
HKD2_k127_6572282_13 PFAM Extracellular ligand-binding receptor K07121 - - 0.00000527 59.0
HKD2_k127_6572282_2 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 379.0
HKD2_k127_6572282_3 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 347.0
HKD2_k127_6572282_4 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 338.0
HKD2_k127_6572282_5 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008916 289.0
HKD2_k127_6572282_6 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001264 281.0
HKD2_k127_6572282_7 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006772 259.0
HKD2_k127_6572282_8 SMART CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002805 247.0
HKD2_k127_6572282_9 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000002652 210.0
HKD2_k127_6572435_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 1.709e-233 730.0
HKD2_k127_6572435_1 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 377.0
HKD2_k127_6572435_10 PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000001265 153.0
HKD2_k127_6572435_11 PFAM cytochrome c, class I K00406 - - 0.00000000000000000000000000000000006673 139.0
HKD2_k127_6572435_12 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000005046 109.0
HKD2_k127_6572435_13 FixH - - - 0.0000000000000004357 92.0
HKD2_k127_6572435_2 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 351.0
HKD2_k127_6572435_3 PFAM ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 351.0
HKD2_k127_6572435_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 346.0
HKD2_k127_6572435_5 PFAM cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 321.0
HKD2_k127_6572435_6 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002685 267.0
HKD2_k127_6572435_7 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007353 247.0
HKD2_k127_6572435_8 CO dehydrogenase acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000008932 177.0
HKD2_k127_6572435_9 AAA domain K07321 - - 0.00000000000000000000000000000000000000000003494 182.0
HKD2_k127_6611601_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.186e-242 760.0
HKD2_k127_6611601_1 thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 7.396e-236 745.0
HKD2_k127_6611601_10 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005776 284.0
HKD2_k127_6611601_11 TIGRFAM acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000483 222.0
HKD2_k127_6611601_12 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000006715 226.0
HKD2_k127_6611601_13 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000005767 211.0
HKD2_k127_6611601_14 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000001395 204.0
HKD2_k127_6611601_15 Glycoprotease family K14742 - - 0.0000000000000000000000000000000000005284 149.0
HKD2_k127_6611601_16 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.000000000000000000000000000000000005085 147.0
HKD2_k127_6611601_17 dihydromethanopterin reductase activity - - - 0.0000000000000005514 89.0
HKD2_k127_6611601_18 Protein of unknown function (DUF465) K09794 - - 0.0000001912 55.0
HKD2_k127_6611601_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703,K20452 - 4.2.1.33,4.2.1.35,4.2.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 610.0
HKD2_k127_6611601_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 515.0
HKD2_k127_6611601_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 373.0
HKD2_k127_6611601_5 Ribosomal protein S2 K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 335.0
HKD2_k127_6611601_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 325.0
HKD2_k127_6611601_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 300.0
HKD2_k127_6611601_8 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 314.0
HKD2_k127_6611601_9 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005126 281.0
HKD2_k127_6637619_0 MlaD protein K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 577.0
HKD2_k127_6637619_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 429.0
HKD2_k127_6637619_2 ABC-type transport auxiliary lipoprotein component - - - 0.000000000000000000000000000000000000000000000003674 179.0
HKD2_k127_6653439_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 550.0
HKD2_k127_6653439_1 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 334.0
HKD2_k127_6653439_10 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.00000000000000000001429 106.0
HKD2_k127_6653439_11 Tetratricopeptide repeat - - - 0.000000000398 72.0
HKD2_k127_6653439_12 - - - - 0.000000001272 67.0
HKD2_k127_6653439_13 Tetratricopeptide repeats - - - 0.0000001396 64.0
HKD2_k127_6653439_14 Roadblock/LC7 domain - - - 0.0000004067 59.0
HKD2_k127_6653439_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009001 267.0
HKD2_k127_6653439_3 PFAM Metallopeptidase family M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000004749 252.0
HKD2_k127_6653439_4 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000000000000000000000000002757 202.0
HKD2_k127_6653439_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000008108 164.0
HKD2_k127_6653439_6 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000008079 166.0
HKD2_k127_6653439_7 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.0000000000000000000000000000000000001278 146.0
HKD2_k127_6653439_8 Diguanylate cyclase - - - 0.0000000000000000000000000000000000009379 160.0
HKD2_k127_6653439_9 Histidine kinase A domain protein - - - 0.0000000000000000000001819 106.0
HKD2_k127_6706422_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.469e-249 781.0
HKD2_k127_6706422_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 612.0
HKD2_k127_6706422_10 - - - - 0.000000000000004286 78.0
HKD2_k127_6706422_11 Protein of unknown function (DUF3343) - - - 0.0000000000001493 74.0
HKD2_k127_6706422_12 Protein of unknown function (DUF721) - - - 0.00003131 54.0
HKD2_k127_6706422_2 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 510.0
HKD2_k127_6706422_3 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 341.0
HKD2_k127_6706422_4 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 325.0
HKD2_k127_6706422_5 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 319.0
HKD2_k127_6706422_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000003286 176.0
HKD2_k127_6706422_7 Methyltransferase small domain protein - - - 0.00000000000000000000000000000000000000000002406 173.0
HKD2_k127_6706422_8 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000007196 166.0
HKD2_k127_6706422_9 Belongs to the SUA5 family K07566 - 2.7.7.87 0.000000000000000000000000000000000291 141.0
HKD2_k127_674003_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1538.0
HKD2_k127_674003_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 568.0
HKD2_k127_674003_2 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 330.0
HKD2_k127_674003_3 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.00000000000000000000000000000000000000000000000000000001425 218.0
HKD2_k127_674003_4 carbonate dehydratase activity - - - 0.00000000000000000000000000000000000000000001536 171.0
HKD2_k127_674003_5 PFAM FecR protein - - - 0.0000000000000000005837 97.0
HKD2_k127_674003_6 Thioesterase superfamily K02614 - - 0.000000000000949 75.0
HKD2_k127_674003_7 - - - - 0.00001416 54.0
HKD2_k127_6804518_0 Belongs to the peptidase M16 family K07263 - - 0.0 1032.0
HKD2_k127_6804518_1 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 372.0
HKD2_k127_6804518_2 Kelch motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 349.0
HKD2_k127_6804518_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000004003 181.0
HKD2_k127_6804518_4 endonuclease containing a URI domain K07461 - - 0.00000000000000001149 92.0
HKD2_k127_6804518_5 regulator of chromosome condensation, RCC1 - - - 0.000000000000005948 89.0
HKD2_k127_6857323_0 Berberine and berberine like - - - 8.738e-221 696.0
HKD2_k127_6857323_1 TRAP transporter solute receptor TAXI family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 606.0
HKD2_k127_6857323_2 Aminotransferase class IV K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 484.0
HKD2_k127_6857323_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000625 189.0
HKD2_k127_6857323_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000006325 164.0
HKD2_k127_6857323_5 Protein involved in formate dehydrogenase formation K02380 - - 0.000000000000000000000000000003705 133.0
HKD2_k127_6869227_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 6.628e-204 651.0
HKD2_k127_6869227_1 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 437.0
HKD2_k127_6869227_2 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 367.0
HKD2_k127_6869227_3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000002224 273.0
HKD2_k127_6869227_4 OmpA family K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006731 242.0
HKD2_k127_6869227_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 0.0000000000000000000000000000000000000000000000003556 199.0
HKD2_k127_6869227_6 GAF domain - - - 0.000000000000000000000000000000000000000000000001929 192.0
HKD2_k127_698345_0 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000915 278.0
HKD2_k127_698345_1 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000004882 179.0
HKD2_k127_698345_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000005543 130.0
HKD2_k127_698345_3 TIGRFAM cytochrome oxidase maturation protein, cbb3-type - - - 0.000000108 62.0
HKD2_k127_6994718_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.0 1072.0
HKD2_k127_6994718_1 PFAM Type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 547.0
HKD2_k127_6994718_10 Belongs to the peptidase S8 family - - - 0.000000002202 66.0
HKD2_k127_6994718_2 Type II and III secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 461.0
HKD2_k127_6994718_3 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 309.0
HKD2_k127_6994718_4 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001414 265.0
HKD2_k127_6994718_5 Type II secretion system (T2SS), protein G K02456 - - 0.000000000000000000000000000000000000000000000000000007281 192.0
HKD2_k127_6994718_6 PFAM General secretion pathway protein K K02460 - - 0.00000000000000000000000000000000000001504 160.0
HKD2_k127_6994718_8 Type II secretion system (T2SS), protein J K02459 - - 0.000000000000002961 88.0
HKD2_k127_6994718_9 Domain present in PSD-95, Dlg, and ZO-1/2. K02452 - - 0.0000000003832 70.0
HKD2_k127_7028166_0 B12 binding domain K00548 - 2.1.1.13 1.693e-318 997.0
HKD2_k127_7028166_1 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 1.196e-271 847.0
HKD2_k127_7028166_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 555.0
HKD2_k127_7028166_3 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 355.0
HKD2_k127_7028166_4 4Fe-4S binding domain K08358 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 354.0
HKD2_k127_7028166_5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000003694 126.0
HKD2_k127_7028166_6 Rubredoxin - - - 0.000000000000005829 90.0
HKD2_k127_7058165_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 590.0
HKD2_k127_7058165_1 PEP-utilising enzyme, N-terminal K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 576.0
HKD2_k127_7058165_10 PFAM permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000002187 182.0
HKD2_k127_7058165_11 Permease YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000002555 188.0
HKD2_k127_7058165_12 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000851 175.0
HKD2_k127_7058165_13 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000897 151.0
HKD2_k127_7058165_14 PFAM PTS system mannose fructose sorbose family IID component K02796 - - 0.00000000000000000000000000000005102 143.0
HKD2_k127_7058165_15 PTS system fructose IIA component K02793 - 2.7.1.191 0.0000000000000000000000000001203 132.0
HKD2_k127_7058165_16 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000001834 132.0
HKD2_k127_7058165_17 PTS system sorbose subfamily IIB component K02794 - 2.7.1.191 0.00000000000000000000000001665 122.0
HKD2_k127_7058165_18 - - - - 0.000000000000000000000007736 103.0
HKD2_k127_7058165_19 PTS system sorbose-specific iic component K02795 - - 0.000000000000000000001115 103.0
HKD2_k127_7058165_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009499 509.0
HKD2_k127_7058165_20 phosphocarrier protein HPr K11189 - - 0.0000000000000000004524 99.0
HKD2_k127_7058165_21 Diguanylate cyclase - - - 0.000000000000000001596 97.0
HKD2_k127_7058165_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 470.0
HKD2_k127_7058165_4 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 363.0
HKD2_k127_7058165_5 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009318 284.0
HKD2_k127_7058165_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000618 280.0
HKD2_k127_7058165_7 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000941 280.0
HKD2_k127_7058165_8 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000004237 260.0
HKD2_k127_7058165_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000349 252.0
HKD2_k127_7203006_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 417.0
HKD2_k127_7203006_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 374.0
HKD2_k127_7203006_2 2-hydroxyglutaryl-CoA dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 331.0
HKD2_k127_7203006_3 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000000000003163 198.0
HKD2_k127_7203006_4 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000002173 169.0
HKD2_k127_7203006_5 2-hydroxyglutaryl-CoA dehydratase, D-component K04112,K20026 - 1.3.7.8,4.2.1.157 0.000000000000000000000000000002464 135.0
HKD2_k127_7203006_6 Tetratricopeptide repeat - - - 0.000000000000000001541 100.0
HKD2_k127_7203006_7 Transcription regulator MerR DNA binding K21902 - - 0.000000000002485 68.0
HKD2_k127_7209707_0 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 581.0
HKD2_k127_7209707_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 505.0
HKD2_k127_7209707_10 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000466 130.0
HKD2_k127_7209707_11 Zincin-like metallopeptidase - - - 0.0000000000000000000000000007478 124.0
HKD2_k127_7209707_12 YacP-like NYN domain K06962 - - 0.00000000005968 71.0
HKD2_k127_7209707_2 PFAM Aminotransferase class I and II K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 420.0
HKD2_k127_7209707_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 352.0
HKD2_k127_7209707_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000117 238.0
HKD2_k127_7209707_5 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000001914 213.0
HKD2_k127_7209707_6 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000002729 236.0
HKD2_k127_7209707_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000007699 155.0
HKD2_k127_7209707_8 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000001037 158.0
HKD2_k127_7209707_9 Glycosyl transferases group 1 K15521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 0.0000000000000000000000000000000000000158 166.0
HKD2_k127_7209850_0 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 385.0
HKD2_k127_7209850_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 355.0
HKD2_k127_72664_0 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000002286 246.0
HKD2_k127_72664_1 PFAM Appr-1-p processing - - - 0.00000000000000000000000000000000000000000000000000000000000003044 230.0
HKD2_k127_72664_2 adenylylsulfate kinase activity K00860,K00955 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000003592 173.0
HKD2_k127_72664_3 cell redox homeostasis - - - 0.0000000000000000000000000000000000246 143.0
HKD2_k127_72664_4 iron ion homeostasis - - - 0.0000000000000000000000000000000001476 151.0
HKD2_k127_72664_5 PFAM DnaJ homologue, subfamily C, member 28, conserved domain - - - 0.000000000000000000000000000000000711 139.0
HKD2_k127_72664_6 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000003422 111.0
HKD2_k127_72664_7 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000001047 93.0
HKD2_k127_7275934_0 CoA binding domain K09181 - - 7.17e-293 906.0
HKD2_k127_7275934_1 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000002312 183.0
HKD2_k127_7303548_0 SMART Nucleotide binding protein, PINc K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 552.0
HKD2_k127_7303548_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 329.0
HKD2_k127_7303548_10 TonB C terminal K03832 - - 0.0000000002706 72.0
HKD2_k127_7303548_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002749 283.0
HKD2_k127_7303548_3 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000001451 194.0
HKD2_k127_7303548_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000999 171.0
HKD2_k127_7303548_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000002599 176.0
HKD2_k127_7303548_6 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000000000000008325 166.0
HKD2_k127_7303548_7 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000000000002092 148.0
HKD2_k127_7303548_8 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000005147 151.0
HKD2_k127_7303548_9 belongs to the Fur family K03711,K09825 - - 0.00000000000000000000001289 105.0
HKD2_k127_7420937_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 367.0
HKD2_k127_7420937_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 307.0
HKD2_k127_7420937_2 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.000000000000000000009258 107.0
HKD2_k127_7455227_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 312.0
HKD2_k127_7455227_1 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000004913 241.0
HKD2_k127_7455227_2 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000005976 181.0
HKD2_k127_7455227_3 protein conserved in bacteria K09798 - - 0.000000000000000000000000000000000001005 147.0
HKD2_k127_7455227_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000002782 72.0
HKD2_k127_752981_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009987 557.0
HKD2_k127_752981_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 462.0
HKD2_k127_752981_2 Sir2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 389.0
HKD2_k127_752981_3 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 346.0
HKD2_k127_752981_4 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001498 292.0
HKD2_k127_752981_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001271 247.0
HKD2_k127_752981_6 Protein conserved in bacteria K09939 - - 0.0000000000000000000000000000000001837 147.0
HKD2_k127_752981_8 Aminoacyl-tRNA editing domain - - - 0.00000002427 64.0
HKD2_k127_752981_9 PFAM Uncharacterised protein family UPF0150 - - - 0.000000249 61.0
HKD2_k127_7699723_0 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000003233 177.0
HKD2_k127_7699723_1 exonuclease activity K16899 - 3.6.4.12 0.0000000000000000000000000000000001907 154.0
HKD2_k127_7699723_2 DNA helicase K03657 - 3.6.4.12 0.000004003 50.0
HKD2_k127_7706611_0 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000002962 188.0
HKD2_k127_7706611_1 - - - - 0.0000000001697 65.0
HKD2_k127_7706611_3 RND efflux system, outer membrane lipoprotein, NodT - - - 0.0001746 48.0
HKD2_k127_7706611_4 Heavy-metal resistance - - - 0.0004277 49.0
HKD2_k127_7717219_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 534.0
HKD2_k127_7745536_0 Predicted permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007651 268.0
HKD2_k127_7745536_1 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009902 239.0
HKD2_k127_7745536_2 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000001221 238.0
HKD2_k127_7745536_3 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000009538 225.0
HKD2_k127_7745536_4 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000004203 162.0
HKD2_k127_7745536_5 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000003369 158.0
HKD2_k127_7745536_6 Beta-L-arabinofuranosidase, GH127 - - - 0.00000000000000000000000000000000002251 156.0
HKD2_k127_7745536_7 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000000000000000001249 92.0
HKD2_k127_7824581_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 588.0
HKD2_k127_7824581_1 PFAM peptidase M16 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 360.0
HKD2_k127_7824581_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000001816 253.0
HKD2_k127_7824581_3 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000007544 184.0
HKD2_k127_7824581_4 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.000000000000000000000000000000000000000000000002644 178.0
HKD2_k127_786094_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.026e-210 674.0
HKD2_k127_786094_1 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000003056 224.0
HKD2_k127_786094_2 Peptidoglycan-binding LysM - - - 0.000000000000000000000009679 115.0
HKD2_k127_7861193_0 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 292.0
HKD2_k127_7861193_1 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000001032 231.0
HKD2_k127_7861193_2 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000001768 103.0
HKD2_k127_7908604_0 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 367.0
HKD2_k127_7908604_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000003545 249.0
HKD2_k127_7908604_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000004913 147.0
HKD2_k127_7908604_3 Beta-L-arabinofuranosidase, GH127 - - - 0.000000000000000000000000000002253 139.0
HKD2_k127_7908604_4 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.0000000000000000000000000001231 123.0
HKD2_k127_7908604_5 ResB-like family - - - 0.00000000000000000000008753 114.0
HKD2_k127_7908604_6 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000308 49.0
HKD2_k127_7908604_7 - - - - 0.0003476 48.0
HKD2_k127_7918148_0 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 332.0
HKD2_k127_7918148_1 peptidase U32 K08303 - - 0.0000000000000000000000001156 109.0
HKD2_k127_7928014_0 Squalene-hopene cyclase C-terminal domain K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 4.309e-279 872.0
HKD2_k127_7928014_1 Radical SAM - - - 1.875e-217 684.0
HKD2_k127_7928014_2 Surface antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 490.0
HKD2_k127_7928014_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 345.0
HKD2_k127_7928014_4 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 300.0
HKD2_k127_7928014_5 Domain of unknown function (DUF3463) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009982 273.0
HKD2_k127_7928014_6 YdjC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000002081 240.0
HKD2_k127_7928014_7 Phosphorylase superfamily - - - 0.000000000000000000000000001885 121.0
HKD2_k127_7942534_0 Molybdopterin oxidoreductase Fe4S4 domain K08357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 579.0
HKD2_k127_7942534_1 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 522.0
HKD2_k127_7942534_2 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 331.0
HKD2_k127_7942534_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000002544 158.0
HKD2_k127_7942534_4 Protein of unknown function (DUF3341) - - - 0.000000000000000009435 92.0
HKD2_k127_7942534_5 cytochrome c - - - 0.00000000002659 74.0
HKD2_k127_7951326_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 2.705e-234 738.0
HKD2_k127_7951326_1 Sporulation and spore germination - - - 0.00000000000000000000623 105.0
HKD2_k127_7951326_2 - - - - 0.0000000000000000009377 93.0
HKD2_k127_7959778_0 COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, alpha subunit K00169 - 1.2.7.1 1.757e-295 924.0
HKD2_k127_7959778_1 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 3.609e-212 666.0
HKD2_k127_7959778_2 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 320.0
HKD2_k127_7959778_3 peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007996 264.0
HKD2_k127_7959778_4 oxidoreductase gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000003603 201.0
HKD2_k127_7959778_5 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000002316 189.0
HKD2_k127_7959778_6 - - - - 0.000000000000000000000000000000000000000000001531 180.0
HKD2_k127_7959778_7 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000003837 178.0
HKD2_k127_7971871_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 482.0
HKD2_k127_7971871_1 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003452 274.0
HKD2_k127_7971871_2 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001987 265.0
HKD2_k127_7971871_3 cheY-homologous receiver domain - - - 0.00000000000000000002214 98.0
HKD2_k127_7971871_4 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000001419 72.0
HKD2_k127_7971871_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000002711 66.0
HKD2_k127_800116_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 424.0
HKD2_k127_800116_1 Transketolase, pyrimidine binding domain K00167,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 372.0
HKD2_k127_800116_2 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 362.0
HKD2_k127_800116_3 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K09699 - 2.3.1.12,2.3.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 342.0
HKD2_k127_800116_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 311.0
HKD2_k127_800116_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000001196 223.0
HKD2_k127_800116_6 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000002878 149.0
HKD2_k127_800116_7 PFAM Nitroreductase K04719,K19286 - 1.13.11.79,1.5.1.39 0.0000000000000000000008337 109.0
HKD2_k127_800116_8 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000001595 66.0
HKD2_k127_800116_9 HMGL-like K02594 - 2.3.3.14 0.000001237 61.0
HKD2_k127_8026846_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 5.959e-233 735.0
HKD2_k127_8026846_1 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 5.421e-202 652.0
HKD2_k127_8026846_10 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000004416 197.0
HKD2_k127_8026846_11 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000002909 145.0
HKD2_k127_8026846_12 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000008047 109.0
HKD2_k127_8026846_13 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000817 100.0
HKD2_k127_8026846_14 Uncharacterised protein family UPF0102 K07460 - - 0.00000000000000001555 97.0
HKD2_k127_8026846_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 564.0
HKD2_k127_8026846_3 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 461.0
HKD2_k127_8026846_4 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 465.0
HKD2_k127_8026846_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 400.0
HKD2_k127_8026846_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 370.0
HKD2_k127_8026846_7 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000003067 264.0
HKD2_k127_8026846_8 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000002288 211.0
HKD2_k127_8026846_9 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000193 198.0
HKD2_k127_8058196_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 9.927e-249 791.0
HKD2_k127_8058196_1 Protein of unknown function (DUF815) K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 348.0
HKD2_k127_8058196_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 346.0
HKD2_k127_8058196_3 DAHP synthetase I family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 329.0
HKD2_k127_8058196_4 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001748 297.0
HKD2_k127_8058196_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000001125 249.0
HKD2_k127_8058196_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000003648 253.0
HKD2_k127_8058196_7 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000003644 243.0
HKD2_k127_8058196_8 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000001477 188.0
HKD2_k127_8058196_9 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000000000000000004726 147.0
HKD2_k127_8072170_0 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 440.0
HKD2_k127_8072170_1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 415.0
HKD2_k127_8072170_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0003855 43.0
HKD2_k127_8083785_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 382.0
HKD2_k127_8083785_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 343.0
HKD2_k127_8104787_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 371.0
HKD2_k127_8104787_1 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 383.0
HKD2_k127_8104787_2 Iron-only hydrogenase maturation rSAM protein HydG K03150 - 4.1.99.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 400.0
HKD2_k127_8104787_3 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 308.0
HKD2_k127_8104787_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 292.0
HKD2_k127_8104787_5 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005046 280.0
HKD2_k127_8104787_6 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000003874 71.0
HKD2_k127_8107007_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 9.535e-279 891.0
HKD2_k127_8107007_1 chelatase subunit ChlI K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 432.0
HKD2_k127_8107007_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 373.0
HKD2_k127_8107007_3 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000001132 217.0
HKD2_k127_8107007_4 N,N-dimethylaniline monooxygenase activity K07222 - - 0.000000000000000000000000000000000000000000000000008672 193.0
HKD2_k127_8107007_5 Ribosomal L27 protein K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000002996 127.0
HKD2_k127_8107007_6 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000003314 115.0
HKD2_k127_8107007_7 HEAT repeats - - - 0.0000004049 60.0
HKD2_k127_8122812_0 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000003784 230.0
HKD2_k127_8122812_1 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000005929 210.0
HKD2_k127_8122812_2 Peptidase family U32 - - - 0.0000000000000000000000000000000000000001923 163.0
HKD2_k127_8122812_3 - - - - 0.000000000000000000000000000000000000009132 154.0
HKD2_k127_8122812_4 peptidase U32 - - - 0.000000000001153 80.0
HKD2_k127_8122812_5 alginic acid biosynthetic process - - - 0.0004462 53.0
HKD2_k127_8130090_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 319.0
HKD2_k127_8130090_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005665 273.0
HKD2_k127_8130090_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000005422 208.0
HKD2_k127_8130090_3 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000159 186.0
HKD2_k127_8130090_4 SurA N-terminal domain K03769 - 5.2.1.8 0.0000000000000000000000000002709 127.0
HKD2_k127_8130090_5 Protein of unknown function (DUF1569) - - - 0.0000001618 64.0
HKD2_k127_8130090_6 Chaperone SurA K03771 - 5.2.1.8 0.0000003212 63.0
HKD2_k127_8146195_0 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000004134 237.0
HKD2_k127_8146195_2 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000002625 208.0
HKD2_k127_8146195_3 Amidohydrolase family K20810 - 3.5.4.40 0.000000000000000000000000000000000000000000000000000002669 208.0
HKD2_k127_8146195_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000009349 171.0
HKD2_k127_8146195_5 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000002075 153.0
HKD2_k127_8146195_6 Short C-terminal domain K08982 - - 0.00003012 50.0
HKD2_k127_8176296_0 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 328.0
HKD2_k127_8176296_1 transport, permease protein K09690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 293.0
HKD2_k127_8176296_2 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000006927 199.0
HKD2_k127_8176296_3 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.000000000000000000000002181 105.0
HKD2_k127_8184716_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 487.0
HKD2_k127_8184716_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 349.0
HKD2_k127_8184716_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000003272 195.0
HKD2_k127_8184716_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000003148 63.0
HKD2_k127_8215583_0 'glutamate synthase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 1.093e-195 622.0
HKD2_k127_8215583_1 Seven times multi-haem cytochrome CxxCH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 597.0
HKD2_k127_8215583_2 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 391.0
HKD2_k127_8215583_3 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 342.0
HKD2_k127_8215583_4 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000584 244.0
HKD2_k127_8215583_5 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000001325 171.0
HKD2_k127_8215583_6 diguanylate cyclase K02488 - 2.7.7.65 0.000000000000000000000000000000000000000009606 169.0
HKD2_k127_8215583_7 Histidine kinase K00936 - 2.7.13.3 0.00000000000000000000000000000000001583 156.0
HKD2_k127_8215583_8 transcription factor binding - - - 0.00000000000000000000008839 112.0
HKD2_k127_8229823_0 Radical SAM K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 459.0
HKD2_k127_8229823_1 Belongs to the N(4) N(6)-methyltransferase family K07319 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 431.0
HKD2_k127_8229823_10 Transcription factor zinc-finger K09981 - - 0.0000000000000000000000000002476 117.0
HKD2_k127_8229823_11 - - - - 0.00000000000000000106 92.0
HKD2_k127_8229823_12 heat shock protein binding - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000003628 68.0
HKD2_k127_8229823_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 325.0
HKD2_k127_8229823_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008871 308.0
HKD2_k127_8229823_4 ATP-dependent DNA helicase activity K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000001284 272.0
HKD2_k127_8229823_5 DMT(Drug metabolite transporter) superfamily permease - - - 0.0000000000000000000000000000000000000000000000000000000000000009912 229.0
HKD2_k127_8229823_6 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.000000000000000000000000000000000000000000000000000003429 214.0
HKD2_k127_8229823_7 Domain of unknown function (DUF4337) - - - 0.0000000000000000000000000000000000000000000000009236 181.0
HKD2_k127_8229823_8 acetyltransferase K18815 - 2.3.1.82 0.00000000000000000000000000000000001326 145.0
HKD2_k127_8229823_9 Helix-turn-helix domain - - - 0.00000000000000000000000000000000001466 141.0
HKD2_k127_8345081_0 Outer membrane usher protein K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 589.0
HKD2_k127_8345081_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 556.0
HKD2_k127_8345081_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003859 460.0
HKD2_k127_8345081_3 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000000000000000000000009508 230.0
HKD2_k127_8345081_4 Spore Coat Protein U domain - - - 0.0000000000000000000000006791 113.0
HKD2_k127_8345081_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000837 93.0
HKD2_k127_8345081_6 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000000000009297 77.0
HKD2_k127_8345081_7 pilus organization K07346 - - 0.00000000002853 66.0
HKD2_k127_8353306_0 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000005387 152.0
HKD2_k127_8353306_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000007017 110.0
HKD2_k127_8353306_2 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000803 97.0
HKD2_k127_8446173_0 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 558.0
HKD2_k127_8455694_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 526.0
HKD2_k127_8455694_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 387.0
HKD2_k127_8455694_2 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 331.0
HKD2_k127_8455694_3 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000006138 188.0
HKD2_k127_8455694_4 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000009607 132.0
HKD2_k127_8455694_5 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.00000000000000000000000003999 114.0
HKD2_k127_850488_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000001215 233.0
HKD2_k127_850488_1 TonB-dependent Receptor Plug Domain K16092 - - 0.00000000000000000000000000000000000000000000000000000000001238 231.0
HKD2_k127_850488_2 Abc transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000002047 207.0
HKD2_k127_8582364_0 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 604.0
HKD2_k127_8582364_1 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 548.0
HKD2_k127_8582364_2 PFAM ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 344.0
HKD2_k127_8582364_3 Cache_2 - - - 0.0000000000000000000000000000000000000000000004922 171.0
HKD2_k127_8582364_4 Carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000005323 134.0
HKD2_k127_8582364_5 - - - - 0.00003201 52.0
HKD2_k127_8665665_0 DoxX K15977 - - 0.000000000000000000000000000000000000007531 150.0
HKD2_k127_8665665_1 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - 0.0000000000000000000000000483 120.0
HKD2_k127_8734267_0 von Willebrand factor (vWF) type A domain K03404,K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000001724 261.0
HKD2_k127_8734267_1 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 0.00000000000000000001823 100.0
HKD2_k127_8735467_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 499.0
HKD2_k127_8735467_1 Formate dehydrogenase N, transmembrane K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 405.0
HKD2_k127_8735467_2 Histidine kinase K10715,K20974 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 398.0
HKD2_k127_8735467_3 Necessary for formate dehydrogenase activity K02380 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 312.0
HKD2_k127_8735467_4 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007837 295.0
HKD2_k127_8735467_5 Prokaryotic cytochrome b561 K00127 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 285.0
HKD2_k127_8735467_6 Enoyl-CoA hydratase K13816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002483 284.0
HKD2_k127_8735467_7 Major Facilitator Superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001912 279.0
HKD2_k127_8735467_8 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03753,K13818 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000001184 226.0
HKD2_k127_8772679_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 4.24e-285 889.0
HKD2_k127_8772679_1 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 559.0
HKD2_k127_8772679_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 468.0
HKD2_k127_8772679_3 Domain of unknown function (DUF362) K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 418.0
HKD2_k127_8772679_4 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 340.0
HKD2_k127_8772679_5 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 309.0
HKD2_k127_8772679_6 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004806 268.0
HKD2_k127_8772679_7 Transcriptional regulator, CarD family K07736 - - 0.00000000000000000000000000000000000000000000000000006869 191.0
HKD2_k127_8772679_8 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.000000000004367 69.0
HKD2_k127_8790711_0 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 389.0
HKD2_k127_8790711_1 Domain of unknown function DUF302 K12308 - 3.2.1.23 0.00000000000000000000006617 104.0
HKD2_k127_8790711_2 - - - - 0.00000000000000000004518 98.0
HKD2_k127_8790711_3 Protein of unknown function (DUF2892) - - - 0.0000000000000000004806 89.0
HKD2_k127_8790711_4 Regulatory protein, FmdB - - - 0.0000003972 54.0
HKD2_k127_8807_0 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 3.276e-227 716.0
HKD2_k127_8807_1 AMP-binding enzyme C-terminal domain - - - 5.247e-223 701.0
HKD2_k127_8807_2 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 556.0
HKD2_k127_8807_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000002265 248.0
HKD2_k127_8807_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000006271 230.0
HKD2_k127_8807_5 4Fe-4S binding domain - - - 0.00000000000000000005979 102.0
HKD2_k127_8807_6 Hydroxyacyl-thioester dehydratase type 2 K14529,K17865 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0018812,GO:0019438,GO:0019637,GO:0019693,GO:0031974,GO:0031981,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035337,GO:0035383,GO:0035384,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046483,GO:0046949,GO:0051186,GO:0051188,GO:0055086,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576 3.1.26.5,4.2.1.55 0.0000000009392 61.0
HKD2_k127_8833448_0 Glucodextranase, domain N K01178 - 3.2.1.3 3.205e-306 979.0
HKD2_k127_8833448_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 334.0
HKD2_k127_8833448_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 314.0
HKD2_k127_8833448_3 cytochrome C family protein - - - 0.0000000000000000000000000000000000001126 148.0
HKD2_k127_8867817_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 363.0
HKD2_k127_8867817_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000009521 151.0
HKD2_k127_8867817_2 radical SAM domain protein - - - 0.000000000000000000005389 104.0
HKD2_k127_8976823_0 Phospholipase A1 K01058 - 3.1.1.32,3.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 365.0
HKD2_k127_8976823_1 chain release factor K15034 - - 0.000000000000000000000000000000000000000000003147 167.0
HKD2_k127_8993662_0 Domain of unknown function (DUF4105) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 549.0
HKD2_k127_8993662_1 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 371.0
HKD2_k127_8993662_10 PFAM Bacterial regulatory proteins, crp family K10914 - - 0.00000000000000000000000001553 118.0
HKD2_k127_8993662_11 PFAM Forkhead-associated protein - - - 0.00000000002748 72.0
HKD2_k127_8993662_2 Alpha/beta hydrolase family K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009329 278.0
HKD2_k127_8993662_3 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002024 268.0
HKD2_k127_8993662_4 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002616 267.0
HKD2_k127_8993662_5 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000000000001464 228.0
HKD2_k127_8993662_6 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.0000000000000000000000000000000000000000000000005975 184.0
HKD2_k127_8993662_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000006356 176.0
HKD2_k127_8993662_8 Protein of unknown function (DUF3015) - - - 0.000000000000000000000000000000000000000003622 172.0
HKD2_k127_9026876_0 PFAM AMP-dependent synthetase and ligase - - - 2.584e-203 655.0
HKD2_k127_9026876_1 PFAM membrane bound O-acyl transferase MBOAT family protein K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 520.0
HKD2_k127_9026876_10 Glycosyltransferase family 10 (fucosyltransferase) C-term - - - 0.000000000000000000000000000000000000000000009618 175.0
HKD2_k127_9026876_11 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000183 143.0
HKD2_k127_9026876_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000004149 89.0
HKD2_k127_9026876_13 - - - - 0.000003608 58.0
HKD2_k127_9026876_2 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 436.0
HKD2_k127_9026876_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 360.0
HKD2_k127_9026876_4 Macrocin-O-methyltransferase (TylF) K05303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 314.0
HKD2_k127_9026876_5 PFAM glycosyl transferase family 9 K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 296.0
HKD2_k127_9026876_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000061 268.0
HKD2_k127_9026876_7 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005945 243.0
HKD2_k127_9026876_8 Glycosyltransferase Family 4 K02844 - - 0.000000000000000000000000000000000000000000000000000000000001722 232.0
HKD2_k127_9026876_9 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000009884 216.0
HKD2_k127_9042463_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 380.0
HKD2_k127_9042463_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000001274 187.0
HKD2_k127_9042463_2 - - - - 0.0000000000001266 82.0
HKD2_k127_9042463_3 Right handed beta helix region - - - 0.0000001526 65.0
HKD2_k127_9104950_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 485.0
HKD2_k127_9104950_1 PFAM Asparaginase glutaminase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 451.0
HKD2_k127_9104950_2 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483,K21726 - 1.14.13.166,1.14.13.29,1.14.14.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 400.0
HKD2_k127_9104950_3 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001283 214.0
HKD2_k127_9104950_4 RNA polymerase sigma factor 70, region 4 type 2 K03088 - - 0.00000000000000000000000000000000000000000001029 167.0
HKD2_k127_9104950_5 - - - - 0.0000000006406 59.0
HKD2_k127_9104950_7 Domain of unknown function (DUF4395) - - - 0.000001176 59.0
HKD2_k127_9110645_0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - 4.086e-218 698.0
HKD2_k127_9110645_1 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004922 261.0
HKD2_k127_9110645_2 CO dehydrogenase acetyl-CoA synthase K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000001603 233.0
HKD2_k127_9110645_3 CO dehydrogenase/acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000117 216.0
HKD2_k127_9110645_4 Ammonium Transporter Family K03320 - - 0.0000000000001393 74.0
HKD2_k127_9111841_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 1.067e-289 906.0
HKD2_k127_9111841_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000001131 222.0
HKD2_k127_9111841_2 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000002416 186.0
HKD2_k127_9226234_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 377.0
HKD2_k127_9226234_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 330.0
HKD2_k127_9226234_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007458 305.0
HKD2_k127_9226234_3 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 299.0
HKD2_k127_9226234_4 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000002 213.0
HKD2_k127_9226234_5 Hydrolase K07025 - - 0.00000000000000000000000000000000000000000000008844 177.0
HKD2_k127_9226234_6 Protein of unknown function (DUF2867) - - - 0.0000000000000000000000007173 104.0
HKD2_k127_9233234_0 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000001577 239.0
HKD2_k127_9233234_1 ACT domain protein K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.0000000000000000000000000000000000000002905 154.0
HKD2_k127_9233234_2 Receptor family ligand binding region K01999 - - 0.0000000000008929 75.0
HKD2_k127_9233234_3 Belongs to the ompA family K03286 - - 0.0007228 51.0
HKD2_k127_9271311_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1049.0
HKD2_k127_9271311_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.072e-275 887.0
HKD2_k127_9271311_10 metallopeptidase activity K01218,K13276 - 3.2.1.78 0.0000000000003038 82.0
HKD2_k127_9271311_11 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0003764 51.0
HKD2_k127_9271311_2 Dehydratase family K01687,K16786 - 4.2.1.9 2.649e-245 767.0
HKD2_k127_9271311_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009209 392.0
HKD2_k127_9271311_4 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 340.0
HKD2_k127_9271311_5 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007506 320.0
HKD2_k127_9271311_6 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000006791 179.0
HKD2_k127_9271311_7 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000002353 109.0
HKD2_k127_9271311_8 SurA N-terminal domain K03769 - 5.2.1.8 0.0000000000000000001633 100.0
HKD2_k127_9271311_9 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000007963 83.0
HKD2_k127_9281_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1092.0
HKD2_k127_9281_1 Aminotransferase K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 507.0
HKD2_k127_9281_10 PFAM outer membrane efflux protein - - - 0.0000000000000000000000000000000000008669 162.0
HKD2_k127_9281_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000004113 154.0
HKD2_k127_9281_12 response regulator - - - 0.0000000000000000000000000000009202 138.0
HKD2_k127_9281_13 NUDIX domain K03574 - 3.6.1.55 0.000000000000000000000000000001543 122.0
HKD2_k127_9281_14 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000002061 133.0
HKD2_k127_9281_15 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000007449 120.0
HKD2_k127_9281_16 Domain of unknown function (DUF1858) - - - 0.0000000000000000001147 90.0
HKD2_k127_9281_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 435.0
HKD2_k127_9281_3 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 396.0
HKD2_k127_9281_4 Efflux ABC transporter permease protein K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001425 301.0
HKD2_k127_9281_5 COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000259 273.0
HKD2_k127_9281_6 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000007308 250.0
HKD2_k127_9281_7 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000000000000004453 218.0
HKD2_k127_9281_8 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000003315 193.0
HKD2_k127_9281_9 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000003776 153.0
HKD2_k127_9307265_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.683e-313 990.0
HKD2_k127_9307265_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.251e-281 888.0
HKD2_k127_9307265_10 PFAM Flavin reductase-like, FMN-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004796 267.0
HKD2_k127_9307265_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002798 291.0
HKD2_k127_9307265_12 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000002844 277.0
HKD2_k127_9307265_13 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001798 261.0
HKD2_k127_9307265_14 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000000000000000000000000000000004062 210.0
HKD2_k127_9307265_15 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000000000000000000000000000000000892 192.0
HKD2_k127_9307265_17 including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000001317 134.0
HKD2_k127_9307265_18 Domain of unknown function (DUF4034) - - - 0.000000000000000000000000000009438 135.0
HKD2_k127_9307265_19 Protein of unknown function (DUF3467) - - - 0.0000000000000002133 84.0
HKD2_k127_9307265_2 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 533.0
HKD2_k127_9307265_20 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000139 53.0
HKD2_k127_9307265_3 Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 485.0
HKD2_k127_9307265_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 483.0
HKD2_k127_9307265_5 Phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 409.0
HKD2_k127_9307265_6 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 377.0
HKD2_k127_9307265_7 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 352.0
HKD2_k127_9307265_8 histidine kinase HAMP region domain protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 340.0
HKD2_k127_9307265_9 NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 306.0
HKD2_k127_9311058_0 NUBPL iron-transfer P-loop NTPase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 312.0
HKD2_k127_9311058_1 PFAM ParB domain protein nuclease K03497 - - 0.00000000000000000000000000000000000000000000000000000000196 226.0
HKD2_k127_9311058_2 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000005774 118.0
HKD2_k127_9336082_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.189e-201 642.0
HKD2_k127_9336082_1 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 587.0
HKD2_k127_9336082_10 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000003754 229.0
HKD2_k127_9336082_11 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000003532 223.0
HKD2_k127_9336082_12 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000001059 194.0
HKD2_k127_9336082_13 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000008128 214.0
HKD2_k127_9336082_14 Diguanylate cyclase - - - 0.00000000000000000000000000000000000001343 166.0
HKD2_k127_9336082_15 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000658 161.0
HKD2_k127_9336082_16 Cold shock protein K03704 - - 0.000000000000000000000003027 103.0
HKD2_k127_9336082_18 NHL repeat - - - 0.000001485 52.0
HKD2_k127_9336082_19 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.000002841 56.0
HKD2_k127_9336082_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004944 534.0
HKD2_k127_9336082_20 COG3087 Cell division protein K03591 - - 0.0007191 49.0
HKD2_k127_9336082_3 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 500.0
HKD2_k127_9336082_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009535 439.0
HKD2_k127_9336082_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 351.0
HKD2_k127_9336082_6 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 319.0
HKD2_k127_9336082_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000005505 230.0
HKD2_k127_9336082_8 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067,K01790,K19997 - 1.1.1.133,5.1.3.13,5.1.3.26 0.000000000000000000000000000000000000000000000000000000000000007431 240.0
HKD2_k127_9336082_9 Belongs to the TrpC family K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000002814 217.0
HKD2_k127_9347603_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 6.957e-270 853.0
HKD2_k127_9347603_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 351.0
HKD2_k127_9347603_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003097 280.0
HKD2_k127_9347603_3 Membrane - - - 0.00000000000000000000000000000001975 135.0
HKD2_k127_9347603_4 catechol 2,3-dioxygenase activity - - - 0.00000000000000000000000000001839 124.0
HKD2_k127_9389278_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 520.0
HKD2_k127_9389278_1 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000123 286.0
HKD2_k127_9389278_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000001186 183.0
HKD2_k127_9389278_3 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000001737 175.0
HKD2_k127_9389278_4 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000008493 133.0
HKD2_k127_9438816_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 423.0
HKD2_k127_9438816_1 GatB domain K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 364.0
HKD2_k127_9438816_2 PFAM Isochorismatase K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000003291 208.0
HKD2_k127_9438816_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000003289 111.0
HKD2_k127_9476860_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 352.0
HKD2_k127_9476860_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000002579 240.0
HKD2_k127_9476860_2 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000005235 229.0
HKD2_k127_948581_0 Heavy metal translocating P-type atpase K01533,K17686 - 3.6.3.4,3.6.3.54 2.378e-201 659.0
HKD2_k127_948581_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 531.0
HKD2_k127_948581_2 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000000000002009 77.0
HKD2_k127_948581_3 Cytochrome oxidase maturation protein - - - 0.0000000001443 63.0
HKD2_k127_9516873_0 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 321.0
HKD2_k127_9516873_1 peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006903 288.0
HKD2_k127_9516873_2 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000002684 116.0
HKD2_k127_9516873_3 Peptidase family U32 K08303 - - 0.0000004734 52.0
HKD2_k127_9535428_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 327.0
HKD2_k127_9535428_1 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000001899 273.0
HKD2_k127_9535428_2 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000001382 111.0
HKD2_k127_9557056_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 349.0
HKD2_k127_9557056_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 312.0
HKD2_k127_9557056_2 3-dehydroquinate synthase (EC 4.6.1.3) K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009896 295.0
HKD2_k127_9557056_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000004287 212.0
HKD2_k127_9557056_4 Protein of unknown function (DUF2400) - - - 0.000000000000000000000000000000000000000000156 168.0
HKD2_k127_9557056_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000001211 81.0
HKD2_k127_9557056_6 TIGRFAM MJ0042 family finger-like protein - - - 0.0000000000000005619 92.0
HKD2_k127_9557056_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000001953 73.0
HKD2_k127_9619192_0 Conserved carboxylase domain K01958 - 6.4.1.1 8.201e-223 711.0
HKD2_k127_9619192_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 516.0
HKD2_k127_9619192_10 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001121 262.0
HKD2_k127_9619192_11 methionine biosynthesis protein (MetW) - - - 0.000000000000000000000000000000000000000000000000000000000003173 230.0
HKD2_k127_9619192_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.000000000000000000000000000000000000000000000000004671 195.0
HKD2_k127_9619192_13 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K09765 - 1.17.99.6 0.000000000000000000000000000000000000000001676 162.0
HKD2_k127_9619192_14 NUDIX domain - - - 0.000000000000000000000000000002973 138.0
HKD2_k127_9619192_15 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000002117 122.0
HKD2_k127_9619192_16 Thioredoxin-like - - - 0.000000000000000005202 97.0
HKD2_k127_9619192_17 Belongs to the ParA family K04562 - - 0.0000005297 56.0
HKD2_k127_9619192_18 PFAM Anti-sigma-28 factor FlgM family protein K02398 - - 0.000001665 54.0
HKD2_k127_9619192_19 Transcriptional regulator - - - 0.0003116 44.0
HKD2_k127_9619192_2 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 507.0
HKD2_k127_9619192_3 ABC transporter K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 479.0
HKD2_k127_9619192_4 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 375.0
HKD2_k127_9619192_5 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 385.0
HKD2_k127_9619192_6 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 363.0
HKD2_k127_9619192_7 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 319.0
HKD2_k127_9619192_8 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 295.0
HKD2_k127_9619192_9 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004438 259.0
HKD2_k127_9645832_0 GTP-binding protein TypA K06207 - - 1.764e-202 641.0
HKD2_k127_9645832_1 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001362 254.0
HKD2_k127_9645832_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00006916 51.0
HKD2_k127_9763742_0 Telomere recombination K04656 - - 4.258e-212 685.0
HKD2_k127_9763742_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 429.0
HKD2_k127_9763742_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001303 280.0
HKD2_k127_9763742_3 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03388 - 1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000007814 268.0
HKD2_k127_9763742_4 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331 - 1.12.1.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000002857 252.0
HKD2_k127_9763742_5 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000001033 199.0
HKD2_k127_9763742_6 PFAM AIR synthase related protein K04655 - - 0.000000000000000000000000000000000005091 154.0
HKD2_k127_9763742_7 Hydrogenase maturation protease K03605 - - 0.00000000000000000000000000261 117.0
HKD2_k127_9763742_8 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000007061 86.0
HKD2_k127_9763742_9 Hydrogenase nickel incorporation protein HypA K04651 - - 0.00000000001168 76.0
HKD2_k127_9786556_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298 - 1.10.3.10,1.9.3.1 5.206e-212 678.0
HKD2_k127_9786556_1 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 534.0
HKD2_k127_9786556_10 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000006429 166.0
HKD2_k127_9786556_11 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.0000000000000000000000000000001896 138.0
HKD2_k127_9786556_12 GPR1/FUN34/yaaH family K07034 - - 0.000000000000000000000000000004259 130.0
HKD2_k127_9786556_13 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000007125 117.0
HKD2_k127_9786556_14 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.00000000000000000000000001413 118.0
HKD2_k127_9786556_15 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000009449 115.0
HKD2_k127_9786556_16 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000001362 101.0
HKD2_k127_9786556_17 oxidase, subunit IV K02277 - 1.9.3.1 0.0000000000006812 72.0
HKD2_k127_9786556_18 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000007512 61.0
HKD2_k127_9786556_2 RNA-metabolising metallo-beta-lactamase K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 524.0
HKD2_k127_9786556_3 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 365.0
HKD2_k127_9786556_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 301.0
HKD2_k127_9786556_5 PFAM Major Facilitator Superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002369 287.0
HKD2_k127_9786556_6 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000328 264.0
HKD2_k127_9786556_7 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000577 200.0
HKD2_k127_9786556_8 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000001154 195.0
HKD2_k127_9786556_9 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000004282 160.0
HKD2_k127_9807844_0 Peptidase dimerisation domain K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 346.0
HKD2_k127_9807844_1 Histidine kinase A domain protein K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 312.0
HKD2_k127_9807844_2 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000000000005139 209.0
HKD2_k127_9807844_3 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000001119 209.0
HKD2_k127_9807844_4 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000517 175.0
HKD2_k127_9807844_5 CHASE - - - 0.000000000000000000000000001535 130.0
HKD2_k127_9807844_6 RDD family - - - 0.00000000000000000014 95.0
HKD2_k127_9857048_0 ubiquinol oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 496.0
HKD2_k127_9857048_1 PFAM cytochrome bd ubiquinol oxidase subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009272 312.0
HKD2_k127_9857048_2 Abc transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 308.0
HKD2_k127_9857048_3 PFAM ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 293.0
HKD2_k127_9857048_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000288 247.0
HKD2_k127_9908940_0 Chase2 domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 528.0
HKD2_k127_9908940_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 317.0
HKD2_k127_9908940_2 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006965 276.0
HKD2_k127_9908940_3 Response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000001378 257.0
HKD2_k127_9908940_4 PFAM OmpA MotB domain protein - - - 0.00000000000000000000000000000000004708 154.0
HKD2_k127_9908940_5 FecR protein - - - 0.000000000000000000000000000000209 130.0
HKD2_k127_9908940_6 sigma-54 factor interaction domain-containing protein K02667 - - 0.00001999 53.0
HKD2_k127_9908940_7 Bacterial regulatory proteins, luxR family - - - 0.0002123 47.0
HKD2_k127_9954701_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 7.489e-213 678.0
HKD2_k127_9954701_1 DNA polymerase K02347 - - 1.042e-212 676.0
HKD2_k127_9954701_2 PFAM Class II aldolase K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 514.0
HKD2_k127_9954701_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 320.0
HKD2_k127_9954701_4 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000002829 200.0
HKD2_k127_9954701_5 electron transport K00196,K05796 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044464,GO:0055114 - 0.0000000000000000000000000000000000002225 149.0
HKD2_k127_9954701_6 RDD family - - - 0.0000000000000000000000000000000007171 141.0
HKD2_k127_9954701_7 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00529,K18249 - 1.18.1.3 0.0000000000000000000000007142 123.0
HKD2_k127_9954701_8 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000000000000000000002042 104.0
HKD2_k127_9954701_9 PFAM Class II aldolase K01628 - 4.1.2.17 0.0000000001804 61.0
HKD2_k127_9957383_0 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000001901 225.0
HKD2_k127_9957383_1 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000003235 161.0
HKD2_k127_9957383_2 Methyltransferase domain - - - 0.000000004842 68.0