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Overview

ID MAG01822
Name HKD2_bin.83
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Dehalococcoidia
Order Dehalococcoidales
Family UBA3254
Genus
Species
Assembly information
Completeness (%) 71.06
Contamination (%) 1.3
GC content (%) 59.0
N50 (bp) 5,353
Genome size (bp) 1,495,772

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1546

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10016316_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 473.0
HKD2_k127_10016316_1 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000001878 148.0
HKD2_k127_10016316_2 - - - - 0.0000000000000000001509 98.0
HKD2_k127_10022637_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 403.0
HKD2_k127_10022637_1 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 303.0
HKD2_k127_10022637_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000005741 190.0
HKD2_k127_10022637_3 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000002958 141.0
HKD2_k127_10022637_4 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000003725 99.0
HKD2_k127_1002406_0 DNA polymerase alpha chain like domain - - - 0.0000000000000000000000000000000000000000000000000000000000003474 218.0
HKD2_k127_1002406_1 Enoyl-(Acyl carrier protein) reductase K07535 - - 0.00000000000000000000000000000000000000000000000001564 189.0
HKD2_k127_1002406_2 ECF sigma factor K03088 - - 0.000000000000000000000000000001632 127.0
HKD2_k127_1002406_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000003251 68.0
HKD2_k127_1002406_4 domain, Protein - - - 0.00000000007959 74.0
HKD2_k127_10032612_0 ABC transporter K06158 - - 1.769e-215 688.0
HKD2_k127_10032612_1 Malic enzyme, NAD binding domain K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 587.0
HKD2_k127_10032612_2 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000005092 215.0
HKD2_k127_10032612_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000001165 207.0
HKD2_k127_10032612_4 Cupin 2, conserved barrel domain protein - - - 0.000000002372 63.0
HKD2_k127_10070664_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 9.796e-196 628.0
HKD2_k127_10070664_1 PFAM Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 535.0
HKD2_k127_10099813_0 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 525.0
HKD2_k127_10099813_1 PFAM MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000971 207.0
HKD2_k127_10099813_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000001965 134.0
HKD2_k127_10101863_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.292e-254 811.0
HKD2_k127_10101863_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009743 270.0
HKD2_k127_10101863_2 Protein of unknown function (DUF1648) - - - 0.000000000000007695 81.0
HKD2_k127_10124796_0 lysyl-tRNA aminoacylation K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006172 604.0
HKD2_k127_10124796_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 526.0
HKD2_k127_10124796_2 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 481.0
HKD2_k127_10124796_3 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002348 271.0
HKD2_k127_10124796_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000002995 122.0
HKD2_k127_10124796_5 Transcription factor zinc-finger K09981 - - 0.000000000000000000000003245 108.0
HKD2_k127_10129770_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 4.871e-225 715.0
HKD2_k127_10129770_1 Cysteine-rich domain K11473,K21834 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 497.0
HKD2_k127_10129770_2 mannitol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 488.0
HKD2_k127_10129770_3 PFAM Extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001357 283.0
HKD2_k127_10129770_4 4Fe-4S dicluster domain K08358 - - 0.000000000000000000000000000000000000000000000000000000000000000000008183 242.0
HKD2_k127_10129770_5 Trap-type c4-dicarboxylate transport system, small permease component K11689 - - 0.00000000000000000000008975 104.0
HKD2_k127_10129770_6 Polysulphide reductase, NrfD - - - 0.000006572 57.0
HKD2_k127_10155679_0 alpha amylase, catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006849 262.0
HKD2_k127_10155679_1 diphthine-ammonia ligase activity K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000003539 203.0
HKD2_k127_10155679_2 Cobinamide kinase / cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000000002181 177.0
HKD2_k127_10155679_3 - - - - 0.0000000000000001084 79.0
HKD2_k127_10175454_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 329.0
HKD2_k127_10175454_1 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00394 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 287.0
HKD2_k127_10175454_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000813 280.0
HKD2_k127_10175454_3 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000009691 168.0
HKD2_k127_10184821_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 513.0
HKD2_k127_10184821_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 304.0
HKD2_k127_10184821_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001621 269.0
HKD2_k127_10184821_3 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000004793 175.0
HKD2_k127_10184821_4 Radical_SAM C-terminal domain K07739 - 2.3.1.48 0.000000000000000000000001108 104.0
HKD2_k127_10194778_0 Acyl-CoA dehydrogenase, N-terminal domain K04117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 351.0
HKD2_k127_10194778_1 Zinc-binding dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000006654 151.0
HKD2_k127_1031077_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 424.0
HKD2_k127_1031077_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 327.0
HKD2_k127_1031077_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001328 274.0
HKD2_k127_1031077_3 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000002266 175.0
HKD2_k127_1060194_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 4.908e-296 920.0
HKD2_k127_1060194_1 histidyl-tRNA aminoacylation K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 537.0
HKD2_k127_1060194_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000004011 205.0
HKD2_k127_1060194_3 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.0000000000000000001041 90.0
HKD2_k127_1060194_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043934,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00001578 52.0
HKD2_k127_112703_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.491e-194 613.0
HKD2_k127_112703_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 532.0
HKD2_k127_112703_2 PFAM PfkB K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 342.0
HKD2_k127_112703_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000002144 175.0
HKD2_k127_1156489_0 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000939 323.0
HKD2_k127_1156489_1 - - - - 0.00000000000000007 87.0
HKD2_k127_1156489_2 4Fe-4S single cluster domain - - - 0.0000000000001529 81.0
HKD2_k127_1156489_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000001837 65.0
HKD2_k127_1174236_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2.285e-294 928.0
HKD2_k127_1178170_0 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 308.0
HKD2_k127_1178170_1 Extradiol ring-cleavage dioxygenase class III protein subunit B K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002901 279.0
HKD2_k127_1178170_2 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000005392 198.0
HKD2_k127_1178170_3 - - - - 0.0000000000000000000000000000008466 135.0
HKD2_k127_1178170_4 - - - - 0.0006817 46.0
HKD2_k127_1209315_0 Carboxylesterase family K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 409.0
HKD2_k127_1209315_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001702 284.0
HKD2_k127_1209315_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000001932 179.0
HKD2_k127_1209315_3 Trypsin - - - 0.00000000000000000000000000000000000000000000002081 180.0
HKD2_k127_1209315_4 Major Facilitator Superfamily - - - 0.000000000000000000000002117 109.0
HKD2_k127_1213584_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000009019 231.0
HKD2_k127_1213584_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000002202 176.0
HKD2_k127_1213584_2 Transmembrane secretion effector K08225 - - 0.000000000000000000000000000000000000001045 164.0
HKD2_k127_1213584_3 SnoaL-like domain - - - 0.0000000000000000000000001043 111.0
HKD2_k127_1244453_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 432.0
HKD2_k127_1244453_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000003131 272.0
HKD2_k127_1244453_2 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000005324 238.0
HKD2_k127_1244453_3 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000006435 80.0
HKD2_k127_1385913_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000002534 218.0
HKD2_k127_1385913_1 Cupin 2, conserved barrel domain protein - - - 0.00000001012 63.0
HKD2_k127_1385936_0 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 367.0
HKD2_k127_1408927_0 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000001752 259.0
HKD2_k127_1408927_1 PSP1 C-terminal conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000001664 223.0
HKD2_k127_1408927_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000067 156.0
HKD2_k127_1408927_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000003074 147.0
HKD2_k127_1408927_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000262 78.0
HKD2_k127_1408927_5 mttA/Hcf106 family K03116 - - 0.00000006674 57.0
HKD2_k127_1416603_0 TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - 0.000000000000000000000000000000000000000000000000000000000000000006062 254.0
HKD2_k127_1416603_1 Thrombospondin C-terminal region - - - 0.00000000000000000000000000000000000000000000000006858 191.0
HKD2_k127_1416603_2 Bacterial protein of unknown function (DUF951) - - - 0.0000000000000000001235 89.0
HKD2_k127_1416603_3 Integrase core domain K07497 - - 0.00000000006769 62.0
HKD2_k127_1416603_4 Tetratricopeptide repeat - - - 0.000009172 57.0
HKD2_k127_1416603_5 Possible Fer4-like domain in RNase L inhibitor, RLI K06174 - - 0.00006949 48.0
HKD2_k127_1469821_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 499.0
HKD2_k127_1469821_1 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 324.0
HKD2_k127_1469821_2 transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003161 287.0
HKD2_k127_1469821_3 Aldo/keto reductase family - - - 0.0001254 46.0
HKD2_k127_1487423_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 461.0
HKD2_k127_1487423_1 4Fe-4S dicluster domain K08358 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 303.0
HKD2_k127_1487423_2 DMSO reductase anchor subunit (DmsC) - - - 0.000000000000000002382 94.0
HKD2_k127_1634247_0 PFAM ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 533.0
HKD2_k127_1634247_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000002367 263.0
HKD2_k127_1634247_2 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000005213 242.0
HKD2_k127_1634247_3 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00000000000000000285 96.0
HKD2_k127_1634247_4 Cytidylate kinase-like family - - - 0.0003683 45.0
HKD2_k127_1678825_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 2.209e-197 633.0
HKD2_k127_1678825_1 Heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 293.0
HKD2_k127_1722353_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 377.0
HKD2_k127_1722353_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004231 274.0
HKD2_k127_1722353_2 50S ribosomal protein L4 K02926 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000001476 239.0
HKD2_k127_1722353_3 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000005063 142.0
HKD2_k127_1722353_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000003879 137.0
HKD2_k127_1722353_5 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000001447 103.0
HKD2_k127_1722353_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000302 76.0
HKD2_k127_1722353_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000008361 74.0
HKD2_k127_1741817_0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007437 381.0
HKD2_k127_1741817_1 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007723 356.0
HKD2_k127_1741817_2 Major facilitator superfamily - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000232 205.0
HKD2_k127_1741817_3 Domain of unknown function (DUF2088) K22373 - 5.1.2.1 0.0000000000000000000000005336 109.0
HKD2_k127_1741817_4 histidine kinase A domain protein - - - 0.0006341 44.0
HKD2_k127_1804288_0 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 312.0
HKD2_k127_1804288_1 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000017 244.0
HKD2_k127_1804288_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000007751 183.0
HKD2_k127_1804288_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000006203 185.0
HKD2_k127_1804288_4 Response regulator receiver - - - 0.000000000000000000000000000000000000006851 154.0
HKD2_k127_1804288_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000002346 145.0
HKD2_k127_1804288_6 PFAM Cytochrome c, bacterial - - - 0.00000000000000005466 91.0
HKD2_k127_1804288_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000005894 65.0
HKD2_k127_1804288_8 - - - - 0.0000122 48.0
HKD2_k127_1806138_0 PFAM molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 326.0
HKD2_k127_1806138_1 Multidrug transporter MatE - - - 0.00000000000000000000000000000000000000000000000000000000001199 223.0
HKD2_k127_1806138_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000001187 189.0
HKD2_k127_1806138_3 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000002533 183.0
HKD2_k127_1806138_4 Probable zinc-ribbon domain - - - 0.000000000000000000000000001442 114.0
HKD2_k127_1806138_5 Winged helix-turn-helix - - - 0.00000000000000000000001158 102.0
HKD2_k127_1806138_6 - - - - 0.00000000000000995 78.0
HKD2_k127_1896070_0 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002347 261.0
HKD2_k127_1896070_1 histidine kinase HAMP region domain protein K07642 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000003764 244.0
HKD2_k127_1896070_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000001084 168.0
HKD2_k127_1896070_3 PFAM response regulator receiver - - - 0.00000000000000000002319 93.0
HKD2_k127_1930139_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 421.0
HKD2_k127_1930139_1 Polysulphide reductase, NrfD - - - 0.00000000000000000002642 102.0
HKD2_k127_1950580_0 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 570.0
HKD2_k127_1950580_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 553.0
HKD2_k127_1950580_10 Belongs to the Fur family K09825 - - 0.00000000000000000000000000000000002103 139.0
HKD2_k127_1950580_11 Concanavalin A-like lectin/glucanases superfamily - - - 0.000000000000000000000009182 114.0
HKD2_k127_1950580_12 Rubredoxin - - - 0.000000000000000000176 88.0
HKD2_k127_1950580_13 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000003541 59.0
HKD2_k127_1950580_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 431.0
HKD2_k127_1950580_3 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 320.0
HKD2_k127_1950580_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 310.0
HKD2_k127_1950580_5 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 289.0
HKD2_k127_1950580_6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005477 276.0
HKD2_k127_1950580_7 PFAM Translin K07477 - - 0.00000000000000000000000000000000000000000000000000000000000001119 225.0
HKD2_k127_1950580_8 PFAM von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000007859 224.0
HKD2_k127_1950580_9 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000009688 204.0
HKD2_k127_1972068_0 Abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002032 258.0
HKD2_k127_1972068_1 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000002449 212.0
HKD2_k127_1972068_2 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000002537 112.0
HKD2_k127_1972068_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0002896 45.0
HKD2_k127_1992882_0 BadF BadG BcrA BcrD - - - 3.446e-261 855.0
HKD2_k127_2030129_0 Domain of unknown function (DUF4131) K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 525.0
HKD2_k127_2030129_1 TrkA-C domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008727 263.0
HKD2_k127_2030129_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000009778 227.0
HKD2_k127_2030129_3 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000001301 202.0
HKD2_k127_2030129_4 Universal stress protein family - - - 0.00000000000000000000000000000000000000002061 156.0
HKD2_k127_2030129_5 Helix-hairpin-helix motif K02237 - - 0.0000000000000000006293 100.0
HKD2_k127_2030129_6 DUF167 K09131 - - 0.00000000000001861 78.0
HKD2_k127_203135_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 493.0
HKD2_k127_203135_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 417.0
HKD2_k127_203135_2 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.0000000000000000000000000000000000000000000000000001774 188.0
HKD2_k127_203135_3 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000000000000001278 155.0
HKD2_k127_203135_4 sulfur carrier activity - - - 0.0000000000000000000000001832 107.0
HKD2_k127_203135_5 - - - - 0.0002138 50.0
HKD2_k127_2045795_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 512.0
HKD2_k127_2045795_1 pfam abc-1 K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 428.0
HKD2_k127_2045795_2 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 297.0
HKD2_k127_2045795_3 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000001024 238.0
HKD2_k127_2045795_4 Protein of unknown function (DUF2851) - - - 0.00000000000000000003194 100.0
HKD2_k127_2045795_5 Thiopurine S-methyltransferase (TPMT) - - - 0.00000001123 64.0
HKD2_k127_2056897_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 555.0
HKD2_k127_2056897_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000001455 241.0
HKD2_k127_2056897_2 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000262 197.0
HKD2_k127_2056897_3 Thioredoxin K03671 - - 0.00000000000000000000000000000001708 134.0
HKD2_k127_2056897_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000007308 107.0
HKD2_k127_2056897_5 - - - - 0.0000000000000006406 80.0
HKD2_k127_2059683_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 514.0
HKD2_k127_2059683_1 Protein of unknown function DUF72 - - - 0.000000000000000000000000006484 111.0
HKD2_k127_2087626_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein K00239,K00244,K17363 - 1.3.5.1,1.3.5.4,1.3.99.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 426.0
HKD2_k127_2087626_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 414.0
HKD2_k127_2087626_2 hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 338.0
HKD2_k127_2087626_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 331.0
HKD2_k127_2087626_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 333.0
HKD2_k127_2087626_5 PFAM Ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008586 278.0
HKD2_k127_2087626_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000009902 120.0
HKD2_k127_2155524_0 abc transporter atp-binding protein K02003 - - 0.000000000000000000000000000000000000000000000000007414 191.0
HKD2_k127_2155524_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000008198 112.0
HKD2_k127_2161649_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835,K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 422.0
HKD2_k127_2161649_1 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 376.0
HKD2_k127_2161649_10 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000002293 52.0
HKD2_k127_2161649_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000001522 248.0
HKD2_k127_2161649_3 Enoyl-(Acyl carrier protein) reductase K00059,K18009,K19548 - 1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76 0.0000000000000000000000000000000000000000000000000000007894 201.0
HKD2_k127_2161649_4 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000001008 175.0
HKD2_k127_2161649_5 acetyltransferase - - - 0.00000000000000000000000000000000000249 147.0
HKD2_k127_2161649_6 ADP-glyceromanno-heptose 6-epimerase activity K01709,K01784,K22025 - 1.1.1.410,4.2.1.45,5.1.3.2 0.000000000000000000000000007535 122.0
HKD2_k127_2161649_7 PFAM DRTGG domain K06873 - - 0.000000000000000000000002221 115.0
HKD2_k127_2161649_8 epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000001508 112.0
HKD2_k127_2161649_9 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000007654 67.0
HKD2_k127_2180769_0 amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009057 425.0
HKD2_k127_2180769_1 ABC transporter, transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 392.0
HKD2_k127_2180769_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 331.0
HKD2_k127_2180769_3 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000005532 270.0
HKD2_k127_2180769_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000008189 184.0
HKD2_k127_2180769_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000001086 167.0
HKD2_k127_2180769_6 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000004936 143.0
HKD2_k127_2180769_7 Regulatory protein, FmdB - - - 0.00000000000000000007464 92.0
HKD2_k127_2180769_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000001366 65.0
HKD2_k127_2200825_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000001374 234.0
HKD2_k127_2200825_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000001281 137.0
HKD2_k127_2200825_2 Conserved hypothetical protein 95 - - - 0.000000000000000000000589 96.0
HKD2_k127_2200825_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000001423 85.0
HKD2_k127_2218447_0 GXGXG motif - - - 0.0 1102.0
HKD2_k127_2218447_1 Conserved region in glutamate synthase - - - 5.044e-257 800.0
HKD2_k127_2218447_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002253 289.0
HKD2_k127_2218447_3 Conserved region in glutamate synthase - - - 0.0000000000000000000000000007778 113.0
HKD2_k127_222050_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005799 275.0
HKD2_k127_222050_1 Transport permease protein K01992,K18233 - - 0.000000000000000000000000000000000000000000000000000000000000000000273 238.0
HKD2_k127_2221876_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 295.0
HKD2_k127_2221876_1 COG COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000001295 224.0
HKD2_k127_2221876_2 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00000000000000000000000000000000002374 146.0
HKD2_k127_2221876_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000003959 90.0
HKD2_k127_2226151_0 PFAM HhH-GPD family protein K07457 - - 0.0000000000000000000000000000000000000000000000000000000000000001014 230.0
HKD2_k127_2226151_1 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000005617 184.0
HKD2_k127_2226151_2 X-Pro dipeptidyl-peptidase domain protein K06978 - - 0.00000000000000000000000000000000000000000001936 169.0
HKD2_k127_2226151_3 TOBE domain - - - 0.000000000000000000003853 94.0
HKD2_k127_2265956_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 319.0
HKD2_k127_2265956_1 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000000000000000000000000000000000000000000001906 203.0
HKD2_k127_2384246_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1103.0
HKD2_k127_2412886_0 PFAM Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 367.0
HKD2_k127_2412886_1 Protein of unknown function (DUF763) K09003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 304.0
HKD2_k127_2412886_2 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003174 258.0
HKD2_k127_2412886_3 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000000000001383 102.0
HKD2_k127_2412886_4 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.0000000000000000001501 89.0
HKD2_k127_2412886_5 TIGRFAM regulatory protein, FmdB - - - 0.000000002027 61.0
HKD2_k127_2412886_6 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0001199 44.0
HKD2_k127_242756_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 439.0
HKD2_k127_242756_1 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002167 261.0
HKD2_k127_242756_2 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
HKD2_k127_242756_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000001261 151.0
HKD2_k127_242756_4 hydrogenase expression formation protein HypE K04655 - - 0.000000000000002197 76.0
HKD2_k127_2492277_0 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 508.0
HKD2_k127_2492277_1 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000267 258.0
HKD2_k127_2493767_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.722e-232 733.0
HKD2_k127_2493767_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 532.0
HKD2_k127_2493767_2 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 522.0
HKD2_k127_2493767_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 294.0
HKD2_k127_2493767_4 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008211 263.0
HKD2_k127_2493767_5 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000202 211.0
HKD2_k127_2493767_6 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000004021 134.0
HKD2_k127_2493767_7 ABC-2 family transporter protein - - - 0.00000000000000000000000002908 123.0
HKD2_k127_2493767_8 Nucleic-acid-binding protein implicated in transcription termination K02600,K07742 - - 0.0000000000000000000004898 103.0
HKD2_k127_2493767_9 NADPH-dependent FMN reductase - - - 0.00006711 46.0
HKD2_k127_250124_0 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 320.0
HKD2_k127_250124_1 Zn-dependent alcohol dehydrogenases K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000005609 159.0
HKD2_k127_2520930_0 Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 372.0
HKD2_k127_2520930_1 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000003572 239.0
HKD2_k127_2524317_0 Ftsk_gamma K03466 - - 3.851e-231 740.0
HKD2_k127_2524317_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006743 583.0
HKD2_k127_2524317_2 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 338.0
HKD2_k127_2524317_3 Calcineurin-like phosphoesterase superfamily domain K22390 - - 0.00000000000000000000000000000000000000000000000000000009573 210.0
HKD2_k127_2524317_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000004067 91.0
HKD2_k127_2524317_5 MarR family - - - 0.00000000000000002386 89.0
HKD2_k127_2550653_0 Fungal trichothecene efflux pump (TRI12) - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 509.0
HKD2_k127_2550653_1 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000001683 226.0
HKD2_k127_2550653_2 Cupin 2, conserved barrel domain protein - - - 0.0001351 46.0
HKD2_k127_2557645_0 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 295.0
HKD2_k127_2557645_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 289.0
HKD2_k127_2557645_10 nUDIX hydrolase K01515,K01518,K01814 - 3.6.1.13,3.6.1.17,5.3.1.16 0.00000000000000000000000000000001649 131.0
HKD2_k127_2557645_11 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000000001498 121.0
HKD2_k127_2557645_12 PFAM thioesterase superfamily - - - 0.00000000000000000000000001273 114.0
HKD2_k127_2557645_13 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0006436 46.0
HKD2_k127_2557645_2 Poly A polymerase head domain K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002805 280.0
HKD2_k127_2557645_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000001704 265.0
HKD2_k127_2557645_4 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000000000000007377 231.0
HKD2_k127_2557645_5 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000005126 203.0
HKD2_k127_2557645_6 Glycoprotease family - - - 0.00000000000000000000000000000000000000000000000000008703 195.0
HKD2_k127_2557645_7 Glycoprotease family - - - 0.000000000000000000000000000000000000000000000000003199 189.0
HKD2_k127_2557645_8 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000000025 172.0
HKD2_k127_2557645_9 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360 2.7.4.6 0.000000000000000000000000000000001146 132.0
HKD2_k127_2594539_0 PFAM aldo keto reductase K07079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 432.0
HKD2_k127_2594539_1 PFAM Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 368.0
HKD2_k127_2594539_2 Haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000004141 221.0
HKD2_k127_2594539_3 Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000007727 210.0
HKD2_k127_2594539_4 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000001083 174.0
HKD2_k127_2599787_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001151 241.0
HKD2_k127_2599787_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000112 210.0
HKD2_k127_2599787_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000134 213.0
HKD2_k127_2599787_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000001229 185.0
HKD2_k127_2599787_4 NMT1/THI5 like - - - 0.00000000000000000000000000000000000005422 155.0
HKD2_k127_2644204_0 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 310.0
HKD2_k127_2644204_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000003399 96.0
HKD2_k127_2686232_0 Domain of unknown function (DUF1998) K06877 - - 1.835e-293 919.0
HKD2_k127_2686232_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 298.0
HKD2_k127_2686232_2 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000000003679 144.0
HKD2_k127_2686232_3 Protein of unknown function (DUF503) K09764 - - 0.00000000000000000000005909 100.0
HKD2_k127_2686232_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000003261 97.0
HKD2_k127_2686556_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 575.0
HKD2_k127_2686556_1 Bacterial dnaA protein K02315 - - 0.000000000000000000000000000000000000000000000000000000000000000000004402 245.0
HKD2_k127_2686556_2 Replication initiation and membrane attachment - - - 0.000000000000000000000000000000000000000000000931 176.0
HKD2_k127_2686556_3 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000004487 128.0
HKD2_k127_2686556_4 - - - - 0.0000003456 54.0
HKD2_k127_2731476_0 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000004558 233.0
HKD2_k127_2731476_1 Membrane transport protein K07088 - - 0.0000000000000000000000000000000004959 142.0
HKD2_k127_2736315_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 2.138e-276 859.0
HKD2_k127_2736315_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.482e-271 844.0
HKD2_k127_2736315_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000001039 248.0
HKD2_k127_2736315_11 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000004345 211.0
HKD2_k127_2736315_12 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000001677 176.0
HKD2_k127_2736315_13 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000002021 178.0
HKD2_k127_2736315_14 Acetolactate synthase small K01653,K16785 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.00000000000000000000000000000000000001253 151.0
HKD2_k127_2736315_15 MgtC family K07507 - - 0.0000000000000000000000000000000000002771 145.0
HKD2_k127_2736315_16 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000004218 91.0
HKD2_k127_2736315_2 dihydroxy-acid dehydratase activity K01687 - 4.2.1.9 6.813e-242 758.0
HKD2_k127_2736315_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.472e-233 731.0
HKD2_k127_2736315_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.449e-202 638.0
HKD2_k127_2736315_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.744e-197 622.0
HKD2_k127_2736315_6 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 505.0
HKD2_k127_2736315_7 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 469.0
HKD2_k127_2736315_8 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 466.0
HKD2_k127_2736315_9 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 443.0
HKD2_k127_2780549_0 electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004519 246.0
HKD2_k127_2780549_1 electron transfer flavoprotein K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 0.00000000000000000000000000000000000000000000001346 177.0
HKD2_k127_2780549_2 Belongs to the peptidase M50B family K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.00000009069 57.0
HKD2_k127_2782894_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 3.237e-223 704.0
HKD2_k127_2782894_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000729 391.0
HKD2_k127_2782894_2 PFAM zinc finger, SWIM domain protein - - - 0.0000000000000000000000000001278 116.0
HKD2_k127_2782894_3 folylpolyglutamate synthase K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000005947 91.0
HKD2_k127_2824566_0 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 346.0
HKD2_k127_2824566_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000001205 184.0
HKD2_k127_2824566_2 Transcriptional regulator IclR K13641 - - 0.000000000000000000000000000005096 127.0
HKD2_k127_2824566_3 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000469 89.0
HKD2_k127_2824566_4 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000945 43.0
HKD2_k127_2830207_0 Hemerythrin HHE cation binding domain K09155 - - 0.0000000000000000000000000000000000000000000000000000005241 204.0
HKD2_k127_2830207_1 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000001537 200.0
HKD2_k127_2830207_2 COG1520 FOG WD40-like repeat - - - 0.00000000000000000000000000000000000000000000000000367 198.0
HKD2_k127_2830207_3 Domain of unknown function (DUF4389) - - - 0.0000000000000000000001829 101.0
HKD2_k127_2830207_4 IMP cyclohydrolase-like protein - - - 0.0000000504 63.0
HKD2_k127_2840192_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 5.683e-246 777.0
HKD2_k127_2840192_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 2.503e-204 647.0
HKD2_k127_2840192_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000163 261.0
HKD2_k127_2840192_3 FAD dependent oxidoreductase K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009346 246.0
HKD2_k127_2840192_4 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000001876 235.0
HKD2_k127_2840192_5 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000009694 216.0
HKD2_k127_2840192_6 PFAM fumarate reductase succinate dehydrogenase flavoprotein K00239,K00244,K17363 - 1.3.5.1,1.3.5.4,1.3.99.33 0.00000000000000000000000000000000000000000000000000000006131 199.0
HKD2_k127_2840192_7 4Fe-4S dicluster domain K00125,K03646 - 1.17.1.9 0.000000000000000000000000000002056 132.0
HKD2_k127_2843546_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004476 259.0
HKD2_k127_2843546_1 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000017 172.0
HKD2_k127_2843546_2 Rhodanese Homology Domain K03972 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.0008605 49.0
HKD2_k127_2869717_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 499.0
HKD2_k127_2869717_1 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000101 231.0
HKD2_k127_2869717_2 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000006561 123.0
HKD2_k127_2876857_0 DNA polymerase X family K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 284.0
HKD2_k127_2876857_1 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004101 279.0
HKD2_k127_2876857_2 - - - - 0.00000000000000000000000000000000000000000000000007413 185.0
HKD2_k127_2876857_3 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000001324 160.0
HKD2_k127_2876857_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000002024 116.0
HKD2_k127_2876857_5 Acyl transferase domain K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.00000000000000000000000004683 110.0
HKD2_k127_2882343_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 438.0
HKD2_k127_2882343_1 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain - - - 0.0000000000000000000000000000000154 130.0
HKD2_k127_2885479_0 FAD linked oxidases, C-terminal domain - - - 3.146e-259 805.0
HKD2_k127_2885479_1 Transcriptional regulator, arsR family - - - 0.0000000000000003375 84.0
HKD2_k127_2885479_2 COG NOG16874 non supervised orthologous group - - - 0.00000000001683 72.0
HKD2_k127_2885479_3 Zinc ribbon domain - - - 0.00000000003554 65.0
HKD2_k127_289293_0 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 467.0
HKD2_k127_289293_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 292.0
HKD2_k127_289293_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000008748 189.0
HKD2_k127_289293_3 PFAM peptidase M48 Ste24p K06013 - 3.4.24.84 0.00000000000000000000000000000000000000003232 168.0
HKD2_k127_289293_4 protein conserved in bacteria (DUF2344) - - - 0.0000000000000000000004301 106.0
HKD2_k127_289293_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000002437 79.0
HKD2_k127_2899717_0 D-galactarate dehydratase / Altronate hydrolase, C terminus K16846 - 4.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 377.0
HKD2_k127_2899717_1 SAF domain K16849 - 4.2.1.7 0.00000000000000000000000001051 111.0
HKD2_k127_2939168_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 9.225e-211 661.0
HKD2_k127_2939168_1 cytochrome c - - - 0.00000000000000000000000000000000000000000002006 173.0
HKD2_k127_2942411_0 PFAM Cytochrome C assembly protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 338.0
HKD2_k127_2942411_1 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005726 266.0
HKD2_k127_2942411_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000002599 262.0
HKD2_k127_2942411_3 PFAM Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002454 259.0
HKD2_k127_2942411_4 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000001246 230.0
HKD2_k127_2942411_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000357 246.0
HKD2_k127_2942411_6 Cytochrome c - - - 0.000000000000000000000000003796 124.0
HKD2_k127_2942411_7 MFS_1 like family - - - 0.000001425 55.0
HKD2_k127_2969869_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 583.0
HKD2_k127_2969869_1 PFAM Aminotransferase class I and II K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 440.0
HKD2_k127_2969869_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000001658 224.0
HKD2_k127_2969869_11 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000525 217.0
HKD2_k127_2969869_12 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000006398 214.0
HKD2_k127_2969869_13 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000004472 203.0
HKD2_k127_2969869_14 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000001959 196.0
HKD2_k127_2969869_15 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000001908 187.0
HKD2_k127_2969869_16 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000003319 176.0
HKD2_k127_2969869_17 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000001071 175.0
HKD2_k127_2969869_18 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000001166 171.0
HKD2_k127_2969869_19 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000005815 162.0
HKD2_k127_2969869_2 Thiamine pyrophosphate enzyme, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 363.0
HKD2_k127_2969869_20 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000005361 154.0
HKD2_k127_2969869_21 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000105 154.0
HKD2_k127_2969869_22 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000005337 151.0
HKD2_k127_2969869_23 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000000001559 153.0
HKD2_k127_2969869_24 structural constituent of ribosome K02879 - - 0.0000000000000000000000000000000000009151 141.0
HKD2_k127_2969869_25 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000001307 141.0
HKD2_k127_2969869_26 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000000009001 123.0
HKD2_k127_2969869_27 Ribosomal protein S17 K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000006911 111.0
HKD2_k127_2969869_28 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000001625 103.0
HKD2_k127_2969869_29 Ribosomal L32p protein family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.00000000000006329 73.0
HKD2_k127_2969869_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 338.0
HKD2_k127_2969869_30 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000002015 70.0
HKD2_k127_2969869_31 structural constituent of ribosome K02904 - - 0.0000000000006878 70.0
HKD2_k127_2969869_32 Ribosomal protein L30p/L7e K02907 - - 0.00000000002939 65.0
HKD2_k127_2969869_4 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 323.0
HKD2_k127_2969869_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001993 257.0
HKD2_k127_2969869_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002461 255.0
HKD2_k127_2969869_7 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000001387 247.0
HKD2_k127_2969869_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000825 220.0
HKD2_k127_2969869_9 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000001145 223.0
HKD2_k127_2975316_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 510.0
HKD2_k127_2975316_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 477.0
HKD2_k127_2975316_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 317.0
HKD2_k127_2975316_3 PFAM LmbE family protein K18455 - 3.5.1.115 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002341 278.0
HKD2_k127_2975316_4 Probable zinc-ribbon domain - - - 0.00000000000000000000000000001438 120.0
HKD2_k127_3001044_0 Tripartite tricarboxylate transporter TctA family - - - 4.238e-219 689.0
HKD2_k127_3001044_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 409.0
HKD2_k127_3001044_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000001766 171.0
HKD2_k127_3001044_3 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000003611 158.0
HKD2_k127_3001044_4 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000006604 136.0
HKD2_k127_3046770_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.14e-212 670.0
HKD2_k127_3046770_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000005772 109.0
HKD2_k127_3046770_2 NfeD-like C-terminal, partner-binding - - - 0.0006993 48.0
HKD2_k127_3057092_0 regulation of RNA biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 300.0
HKD2_k127_3057092_1 COG2041 Sulfite oxidase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 292.0
HKD2_k127_3057092_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000002384 199.0
HKD2_k127_3057092_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000001904 175.0
HKD2_k127_3057092_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000004836 117.0
HKD2_k127_3057092_5 - - - - 0.00000000000000000000000278 108.0
HKD2_k127_3057092_6 Belongs to the peptidase M50B family K06402 - - 0.00000000000000000000002689 103.0
HKD2_k127_3079155_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 429.0
HKD2_k127_3079155_1 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000009228 229.0
HKD2_k127_3079155_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000009698 197.0
HKD2_k127_3103153_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 371.0
HKD2_k127_3103153_1 L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000134 269.0
HKD2_k127_3103153_2 COG0530 Ca2 Na antiporter K07301 - - 0.00000000000000005269 81.0
HKD2_k127_3103153_3 helix_turn_helix multiple antibiotic resistance protein K06075 - - 0.0000000004917 64.0
HKD2_k127_3139011_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 368.0
HKD2_k127_3139011_1 PFAM short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000001046 209.0
HKD2_k127_3139011_2 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000007133 194.0
HKD2_k127_3139011_3 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000003621 178.0
HKD2_k127_3139011_4 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.00000000000000000000000001087 115.0
HKD2_k127_3139011_5 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - 0.00000000000000000000000001588 119.0
HKD2_k127_3139011_6 NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000001269 83.0
HKD2_k127_3139011_7 Cupin 2, conserved barrel domain protein - - - 0.00001705 54.0
HKD2_k127_3151311_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 509.0
HKD2_k127_3151311_1 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 312.0
HKD2_k127_3151311_2 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000003673 228.0
HKD2_k127_3151311_3 NYN domain - - - 0.0000000000000000000000000000000000000001968 158.0
HKD2_k127_3151311_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000003659 68.0
HKD2_k127_3151311_5 - K01992 - - 0.000006431 57.0
HKD2_k127_3151311_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0001207 47.0
HKD2_k127_3212774_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 302.0
HKD2_k127_3212774_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000004232 158.0
HKD2_k127_3212774_3 - K03975 - - 0.00002681 51.0
HKD2_k127_3237105_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00394 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 559.0
HKD2_k127_3237105_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000007978 176.0
HKD2_k127_3237105_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000159 132.0
HKD2_k127_3237105_3 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000008018 112.0
HKD2_k127_3237105_4 acetyltransferase K03789,K14742 - 2.3.1.128 0.000004263 55.0
HKD2_k127_3237105_5 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0001568 48.0
HKD2_k127_3237105_6 PAS domain - - - 0.0004414 48.0
HKD2_k127_3250427_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000003533 115.0
HKD2_k127_3250427_1 Transcriptional regulator, MerR family K13638,K13640,K21745,K21902 - - 0.000000000000005975 79.0
HKD2_k127_3250427_2 protein, possibly involved in utilization of glycolate and propanediol - - - 0.00000000000001932 78.0
HKD2_k127_3250427_3 translation release factor activity - - - 0.000000008278 65.0
HKD2_k127_3250427_4 Haem-degrading - - - 0.0001616 46.0
HKD2_k127_3338014_0 GH3 auxin-responsive promoter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 424.0
HKD2_k127_3338014_1 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000001265 128.0
HKD2_k127_3361470_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.000000000000001678 83.0
HKD2_k127_3361470_1 Recombinase zinc beta ribbon domain - - - 0.00001617 50.0
HKD2_k127_3370912_0 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 505.0
HKD2_k127_3370912_1 - - - - 0.0000000000000000000000000000000000002571 147.0
HKD2_k127_3370912_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.000000000000000000000002078 106.0
HKD2_k127_3379023_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 493.0
HKD2_k127_3379023_1 Major facilitator Superfamily K08177,K18326 - - 0.0000000000000000000000000000000000000000000000004503 183.0
HKD2_k127_3379869_0 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001066 256.0
HKD2_k127_3379869_1 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000367 224.0
HKD2_k127_3379869_2 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.00000000000000000000000000000000000000000000000000000000001392 213.0
HKD2_k127_3379869_3 Psort location CytoplasmicMembrane, score 10.00 - - - 0.0000000000000000003568 92.0
HKD2_k127_3379869_4 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000004677 78.0
HKD2_k127_3390242_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000202 131.0
HKD2_k127_3398879_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 526.0
HKD2_k127_3398879_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 393.0
HKD2_k127_3398879_2 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 346.0
HKD2_k127_3398879_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000007457 211.0
HKD2_k127_3398879_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000001723 138.0
HKD2_k127_3398879_5 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000004284 65.0
HKD2_k127_3423233_0 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 308.0
HKD2_k127_3423233_1 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000257 224.0
HKD2_k127_3423233_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000002518 171.0
HKD2_k127_3424341_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.332e-281 882.0
HKD2_k127_3424341_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000004161 270.0
HKD2_k127_3424341_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000004022 222.0
HKD2_k127_3424341_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001433 192.0
HKD2_k127_3424341_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000001985 126.0
HKD2_k127_3432890_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00394 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000686 533.0
HKD2_k127_3432890_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 328.0
HKD2_k127_3432890_2 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000001994 105.0
HKD2_k127_3443062_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 4.926e-221 695.0
HKD2_k127_3443062_1 PKD domain containing protein K01337,K20276,K21449 - 3.4.21.50 0.0000000000000000000000000000000000000000000000000000000000000003043 235.0
HKD2_k127_3443062_2 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000006145 164.0
HKD2_k127_3443062_3 protein involved in propionate catabolism - - - 0.0002309 48.0
HKD2_k127_3483236_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000009409 241.0
HKD2_k127_3483236_1 PAC2 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002242 239.0
HKD2_k127_3483236_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000004472 245.0
HKD2_k127_3483236_3 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000001031 173.0
HKD2_k127_3483236_4 Belongs to the SfsA family K06206 - - 0.000000000000000000000006884 108.0
HKD2_k127_3483236_5 - - - - 0.00000000000007161 76.0
HKD2_k127_3488908_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.793e-247 774.0
HKD2_k127_3488908_1 arginyl-tRNA aminoacylation K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 372.0
HKD2_k127_3488908_10 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000001303 92.0
HKD2_k127_3488908_11 - - - - 0.00000000001205 67.0
HKD2_k127_3488908_2 Pfam:Kce K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 353.0
HKD2_k127_3488908_3 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 326.0
HKD2_k127_3488908_4 Polyprenyl synthetase K00805,K02523 - 2.5.1.30,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 302.0
HKD2_k127_3488908_5 PFAM 3-hydroxyacyl-CoA dehydrogenase K00074,K17735 - 1.1.1.108,1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000006606 256.0
HKD2_k127_3488908_6 cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002967 235.0
HKD2_k127_3488908_7 Coenzyme A transferase K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000001117 229.0
HKD2_k127_3488908_8 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000001676 209.0
HKD2_k127_3488908_9 3-oxoacid CoA-transferase, B subunit K01029 GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0036293,GO:0050896,GO:0070482 2.8.3.5 0.0000000000000000000000000000000000000000000000000000004584 204.0
HKD2_k127_349003_0 ROK family K00845,K00847 - 2.7.1.2,2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 392.0
HKD2_k127_349003_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 320.0
HKD2_k127_349003_2 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002754 282.0
HKD2_k127_349003_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006362 260.0
HKD2_k127_349003_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000147 264.0
HKD2_k127_349003_5 Abc-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000008986 202.0
HKD2_k127_349003_6 - - - - 0.000000003869 62.0
HKD2_k127_349003_7 Helix-turn-helix domain - - - 0.00000004765 57.0
HKD2_k127_349003_8 Evidence 4 Homologs of previously reported genes of - - - 0.000002943 53.0
HKD2_k127_3530647_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000001915 226.0
HKD2_k127_3530647_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000001519 137.0
HKD2_k127_3577540_0 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 474.0
HKD2_k127_3577540_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002378 276.0
HKD2_k127_3577540_10 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000001812 70.0
HKD2_k127_3577540_11 Domain of unknown function (DUF4129) - - - 0.00000001065 68.0
HKD2_k127_3577540_2 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001336 268.0
HKD2_k127_3577540_3 60Kd inner membrane protein K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000001264 233.0
HKD2_k127_3577540_4 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000000000000000004171 188.0
HKD2_k127_3577540_5 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000006502 126.0
HKD2_k127_3577540_6 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000003413 110.0
HKD2_k127_3577540_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000001585 107.0
HKD2_k127_3577540_8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000003385 94.0
HKD2_k127_3577540_9 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000005993 87.0
HKD2_k127_3598760_0 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 329.0
HKD2_k127_3598760_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 285.0
HKD2_k127_3598760_2 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000003292 163.0
HKD2_k127_3598760_3 Probable zinc-ribbon domain - - - 0.000000000000000000000000000000000000001919 148.0
HKD2_k127_3618602_0 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000003493 211.0
HKD2_k127_3618602_1 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000003947 190.0
HKD2_k127_3618602_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000006015 162.0
HKD2_k127_3686224_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 596.0
HKD2_k127_3686224_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 512.0
HKD2_k127_3686224_2 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 440.0
HKD2_k127_3686224_3 Transcriptional regulator IclR K13641 - - 0.0000000000000000000000000000000000000002776 159.0
HKD2_k127_3686224_4 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000001191 70.0
HKD2_k127_3686224_5 Molydopterin dinucleotide binding domain K07306,K07812 - 1.7.2.3,1.8.5.3 0.0000621 48.0
HKD2_k127_3703594_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 3.201e-314 985.0
HKD2_k127_3703594_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000796 212.0
HKD2_k127_3703594_2 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.000000000000000000000000000002578 122.0
HKD2_k127_3709479_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 349.0
HKD2_k127_3709479_1 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001043 245.0
HKD2_k127_3709479_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000005091 204.0
HKD2_k127_3709479_3 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000005276 182.0
HKD2_k127_3709479_4 NifU-like domain - - - 0.0000000000000000000000008298 111.0
HKD2_k127_3738408_0 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 315.0
HKD2_k127_3738408_1 PHP-associated - - - 0.00000000000000000000000000000000000000000000001449 176.0
HKD2_k127_3738408_2 Glyoxalase-like domain K01759,K08234 - 4.4.1.5 0.000000000000000000000000000000000006774 141.0
HKD2_k127_378761_0 FAD linked oxidase domain protein K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 379.0
HKD2_k127_378761_1 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000005922 216.0
HKD2_k127_3823716_0 magnesium chelatase K03405 - 6.6.1.1 0.0000000000000000000000000000000008458 143.0
HKD2_k127_3823716_1 Cupin 2, conserved barrel domain protein - - - 0.000000000000122 77.0
HKD2_k127_3823716_2 Cupin 2, conserved barrel domain protein - - - 0.000000000009469 71.0
HKD2_k127_3823716_3 PFAM von Willebrand factor type A - - - 0.000796 53.0
HKD2_k127_3837754_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 421.0
HKD2_k127_3837754_1 thiamine pyrophosphate protein TPP binding domain protein K00156,K01652 - 1.2.5.1,2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 402.0
HKD2_k127_3837754_2 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000003058 222.0
HKD2_k127_3837754_3 Psort location Cytoplasmic, score K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000576 191.0
HKD2_k127_3837754_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000003815 190.0
HKD2_k127_3837754_5 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000001221 94.0
HKD2_k127_3837754_6 - - - - 0.0000000000000000387 84.0
HKD2_k127_3848494_0 PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738,K19515 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000005069 243.0
HKD2_k127_3848494_1 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000001956 116.0
HKD2_k127_3848494_2 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000325 59.0
HKD2_k127_3876825_0 histidine kinase A domain protein K02484,K07642 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009239 317.0
HKD2_k127_3876825_1 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001113 274.0
HKD2_k127_3876825_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000559 119.0
HKD2_k127_3927280_0 Elongation factor G C-terminus K06207 - - 1.617e-278 867.0
HKD2_k127_3927280_1 Thermophilic metalloprotease (M29) K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 488.0
HKD2_k127_3927280_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 468.0
HKD2_k127_3927280_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K09765 - 1.17.99.6 0.000000000000000000000000000000000000000178 156.0
HKD2_k127_3927280_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000509 152.0
HKD2_k127_3927280_5 Probable zinc-ribbon domain - - - 0.000000000000000000000000000000000000071 147.0
HKD2_k127_3927280_6 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000009486 111.0
HKD2_k127_3934459_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 7.766e-235 748.0
HKD2_k127_3934459_1 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 424.0
HKD2_k127_3934459_2 ferredoxin oxidoreductase, alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000001529 228.0
HKD2_k127_3934459_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.000000000000000000000000000000000001436 143.0
HKD2_k127_3934459_4 KR domain - - - 0.00000000000000000000005509 100.0
HKD2_k127_3934459_5 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.00000000000000000002414 94.0
HKD2_k127_3948988_0 Biotin carboxylase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 397.0
HKD2_k127_3948988_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000007746 148.0
HKD2_k127_3958397_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 434.0
HKD2_k127_3958397_1 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 414.0
HKD2_k127_3958397_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 350.0
HKD2_k127_3958397_3 HAD-hyrolase-like K20862 - 3.1.3.102,3.1.3.104 0.0000000000000000000000000004328 119.0
HKD2_k127_3972871_0 Rubredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 291.0
HKD2_k127_3972871_1 PFAM Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000001855 203.0
HKD2_k127_4001729_0 Domain of unknown function(DUF2779) - - - 0.0000000000000000000000000000000000000000000000000000000000003496 227.0
HKD2_k127_4001729_1 Enoyl-(Acyl carrier protein) reductase K07535 - - 0.000000000000000000000000000000000000000000000000001128 192.0
HKD2_k127_4001729_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000001364 180.0
HKD2_k127_4001729_3 - - - - 0.0000000001437 66.0
HKD2_k127_4028800_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 426.0
HKD2_k127_4028800_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 412.0
HKD2_k127_4028800_2 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029,K01035 - 2.8.3.5,2.8.3.8,2.8.3.9 0.0000000000000000000000000000000000000000000000000000000000000000001886 237.0
HKD2_k127_4028800_3 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000002345 223.0
HKD2_k127_4028800_4 Enoyl-CoA hydratase/isomerase K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.00000000000000000000000000000000004362 139.0
HKD2_k127_4028800_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000000002136 130.0
HKD2_k127_4028800_6 PFAM Antibiotic biosynthesis monooxygenase - - - 0.00000000000003236 77.0
HKD2_k127_4068311_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 509.0
HKD2_k127_4068311_1 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001203 228.0
HKD2_k127_4068311_2 FCD - - - 0.00000000000000000000000000000408 129.0
HKD2_k127_4068311_3 PFAM nitrogen-fixing NifU domain protein - - - 0.0000000000000000000000000111 110.0
HKD2_k127_4083034_0 In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 K09020 - 3.5.1.110 0.00000000000000000000000000000000000000000000000000000000000000000002614 240.0
HKD2_k127_4083034_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000241 224.0
HKD2_k127_4083034_2 Domain of unknown function (DUF4870) - - - 0.0000000000000000000000000002222 120.0
HKD2_k127_4083034_3 hydrolase activity, acting on ester bonds K07051 - - 0.000000000000000000000000008824 120.0
HKD2_k127_4083034_4 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.0000000000000000002714 93.0
HKD2_k127_4083034_5 PFAM oxidoreductase, molybdopterin binding - - - 0.00008545 51.0
HKD2_k127_4127411_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.232e-207 651.0
HKD2_k127_4127411_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000003043 49.0
HKD2_k127_4135592_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001579 255.0
HKD2_k127_4135592_1 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000005112 106.0
HKD2_k127_4157702_0 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 407.0
HKD2_k127_4157702_1 involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 369.0
HKD2_k127_4157702_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K07402 - - 0.000000000000000000000000000000000000000000000000007649 190.0
HKD2_k127_4157702_3 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.0000000000000000000000000000000000000000000000648 173.0
HKD2_k127_4174263_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1117.0
HKD2_k127_4174263_1 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 590.0
HKD2_k127_4174263_2 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 404.0
HKD2_k127_4174263_3 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000001521 211.0
HKD2_k127_4174263_4 Heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000004228 156.0
HKD2_k127_4174263_5 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.000000000000000000000000001374 115.0
HKD2_k127_4174263_6 Hydrogenase maturation protease K03605 - - 0.00000001079 58.0
HKD2_k127_418877_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 1.695e-201 636.0
HKD2_k127_418877_1 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 497.0
HKD2_k127_418877_2 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 317.0
HKD2_k127_418877_3 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000003122 270.0
HKD2_k127_418877_4 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000003342 229.0
HKD2_k127_418877_5 AMP binding - - - 0.00000000000000000000000000271 117.0
HKD2_k127_418877_6 Phosphoribosyl transferase domain - - - 0.000000003855 59.0
HKD2_k127_4197494_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 604.0
HKD2_k127_4197494_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006851 556.0
HKD2_k127_4197494_2 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 437.0
HKD2_k127_4197494_3 UbiA prenyltransferase family K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 309.0
HKD2_k127_4197494_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000038 161.0
HKD2_k127_4197494_5 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000001407 92.0
HKD2_k127_4239088_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 606.0
HKD2_k127_4239088_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 560.0
HKD2_k127_4239088_10 phosphoribosylanthranilate isomerase activity K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000005315 188.0
HKD2_k127_4239088_11 4Fe-4S ferredoxin iron-sulfur binding domain protein K11473 - - 0.000000000000000000000000000000000000000000002865 176.0
HKD2_k127_4239088_12 - - - - 0.000000000000000000000000000002777 124.0
HKD2_k127_4239088_13 Dihydroxyacetone kinase family - - - 0.000000000000000000000000000002857 130.0
HKD2_k127_4239088_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 455.0
HKD2_k127_4239088_3 NeuB family K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 412.0
HKD2_k127_4239088_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 364.0
HKD2_k127_4239088_5 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 300.0
HKD2_k127_4239088_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 300.0
HKD2_k127_4239088_7 indole-3-glycerol-phosphate synthase activity K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003502 280.0
HKD2_k127_4239088_8 PFAM Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000136 267.0
HKD2_k127_4239088_9 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000000000001861 214.0
HKD2_k127_4252356_0 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 573.0
HKD2_k127_4252356_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 521.0
HKD2_k127_4252356_2 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001933 270.0
HKD2_k127_4252356_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000002893 237.0
HKD2_k127_4252356_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000179 221.0
HKD2_k127_4252356_5 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000001212 222.0
HKD2_k127_4252356_6 - - - - 0.0000002636 62.0
HKD2_k127_4252356_7 ThiS family K03636 - - 0.000002653 55.0
HKD2_k127_4252356_8 - - - - 0.00001579 49.0
HKD2_k127_426000_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004741 271.0
HKD2_k127_426000_1 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000006696 248.0
HKD2_k127_426000_2 CoA binding domain - - - 0.000001775 51.0
HKD2_k127_4286147_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 328.0
HKD2_k127_4286147_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 323.0
HKD2_k127_4286147_2 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003206 248.0
HKD2_k127_4286147_3 PFAM phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000145 163.0
HKD2_k127_4286147_4 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00000000000000005674 82.0
HKD2_k127_4323881_0 amidohydrolase K03392,K07045 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000008975 237.0
HKD2_k127_4323881_1 Dihydroxyacetone kinase family - - - 0.00000000000000000000000000000000000000000004976 171.0
HKD2_k127_4354200_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 384.0
HKD2_k127_4354200_1 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002136 269.0
HKD2_k127_4354200_2 Peptidase family M28 - - - 0.00000000001467 75.0
HKD2_k127_4354200_3 - - - - 0.0000000004737 64.0
HKD2_k127_4423597_0 Protein of unknown function, DUF255 K06888 - - 2.607e-201 644.0
HKD2_k127_4423597_1 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000007197 224.0
HKD2_k127_4423597_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000009437 171.0
HKD2_k127_4423597_3 PFAM Rubrerythrin - - - 0.0000000000001108 77.0
HKD2_k127_4469461_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000005154 205.0
HKD2_k127_4469461_1 Nitroreductase - - - 0.0000000000000000000000000000000000000003173 157.0
HKD2_k127_4469461_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000003431 85.0
HKD2_k127_4469461_3 Aldo/keto reductase family - - - 0.00000009069 57.0
HKD2_k127_4541417_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 4.093e-202 642.0
HKD2_k127_4541417_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 293.0
HKD2_k127_4541417_2 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005868 278.0
HKD2_k127_4541417_3 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007483 260.0
HKD2_k127_4541417_4 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000001126 190.0
HKD2_k127_4541417_5 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000007223 169.0
HKD2_k127_4541417_6 Protein of unknown function (DUF664) - - - 0.0000000000000000008793 91.0
HKD2_k127_4552810_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 1.938e-246 779.0
HKD2_k127_4552810_1 Efflux ABC transporter permease protein K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 328.0
HKD2_k127_4552810_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000002402 227.0
HKD2_k127_4552810_3 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000005786 227.0
HKD2_k127_4552810_4 Serine aminopeptidase, S33 K01048 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000001835 209.0
HKD2_k127_4552810_6 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000003371 58.0
HKD2_k127_4552810_7 Biotin-lipoyl like K02005,K13888 - - 0.00003051 52.0
HKD2_k127_4601951_0 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 578.0
HKD2_k127_4601951_1 iron-sulfur cluster assembly K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 516.0
HKD2_k127_4601951_2 PFAM response regulator receiver K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 296.0
HKD2_k127_4601951_3 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000212 283.0
HKD2_k127_4636748_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 615.0
HKD2_k127_4636748_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 488.0
HKD2_k127_4636748_10 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000003069 167.0
HKD2_k127_4636748_11 2-dehydropantoate 2-reductase activity K00077 - 1.1.1.169 0.00000000000000000000000000000000001852 142.0
HKD2_k127_4636748_12 Cupin 2, conserved barrel domain protein - - - 0.00003956 55.0
HKD2_k127_4636748_13 Cupin 2, conserved barrel domain protein - - - 0.0009151 50.0
HKD2_k127_4636748_2 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 439.0
HKD2_k127_4636748_3 NADH flavin oxidoreductase NADH oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 450.0
HKD2_k127_4636748_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 433.0
HKD2_k127_4636748_5 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 411.0
HKD2_k127_4636748_6 ABC transporter permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 323.0
HKD2_k127_4636748_7 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 301.0
HKD2_k127_4636748_8 Molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000002647 233.0
HKD2_k127_4636748_9 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000007185 204.0
HKD2_k127_4748997_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.15e-256 814.0
HKD2_k127_4748997_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 435.0
HKD2_k127_4748997_2 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 309.0
HKD2_k127_4748997_3 TIGRFAM molybdenum cofactor synthesis domain - - - 0.000000000000000000000000000000000000000000000000002621 186.0
HKD2_k127_4748997_4 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000000000000000000000000006253 178.0
HKD2_k127_4748997_5 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000005625 136.0
HKD2_k127_4771122_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 511.0
HKD2_k127_4771122_1 Oxidoreductase molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000004521 223.0
HKD2_k127_4771122_2 HEAT repeats - - - 0.0000000000000000000000154 109.0
HKD2_k127_4771122_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000001415 69.0
HKD2_k127_481206_0 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009088 318.0
HKD2_k127_481206_1 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000001781 165.0
HKD2_k127_481206_2 ABC transporter substrate-binding protein K02035 - - 0.000000000000008802 83.0
HKD2_k127_481206_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000005165 60.0
HKD2_k127_481206_5 Member of the two-component regulatory system DegS DegU, which plays an important role in the transition growth phase K07777 - 2.7.13.3 0.0000005554 51.0
HKD2_k127_4813471_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 1.164e-218 687.0
HKD2_k127_4813471_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000001489 169.0
HKD2_k127_4813471_2 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000001635 134.0
HKD2_k127_4813471_3 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000000000000000000000000003083 118.0
HKD2_k127_4813471_4 PFAM Vitamin B12 dependent methionine synthase, activation domain - - - 0.0000002295 54.0
HKD2_k127_489383_0 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 305.0
HKD2_k127_489383_1 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 312.0
HKD2_k127_489383_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000406 128.0
HKD2_k127_4927407_0 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 346.0
HKD2_k127_4927407_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002267 286.0
HKD2_k127_4927407_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000007119 228.0
HKD2_k127_4927407_3 PFAM PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000006259 224.0
HKD2_k127_4927407_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K01905,K11175,K22224 - 2.1.2.2,6.2.1.13 0.00000000000000000000000000000000000000000000000000000545 200.0
HKD2_k127_4927407_5 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000000003982 163.0
HKD2_k127_4927407_6 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000277 165.0
HKD2_k127_4943000_0 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 383.0
HKD2_k127_4943000_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006914 320.0
HKD2_k127_4943000_2 FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000001081 219.0
HKD2_k127_4943000_3 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000006077 140.0
HKD2_k127_4943000_4 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000001271 129.0
HKD2_k127_4989936_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 511.0
HKD2_k127_4989936_1 Adenine deaminase C-terminal domain K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 502.0
HKD2_k127_4989936_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 477.0
HKD2_k127_4989936_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 311.0
HKD2_k127_4989936_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000246 166.0
HKD2_k127_5102177_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008589 607.0
HKD2_k127_5102177_1 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 325.0
HKD2_k127_5102177_2 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 309.0
HKD2_k127_5102177_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP - - - 0.0000000000000000000000000000000000000000000002285 175.0
HKD2_k127_5102177_4 Fe-S oxidoreductase - - - 0.000000000000000000000000002706 119.0
HKD2_k127_5140660_0 E3 Ubiquitin ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007401 425.0
HKD2_k127_5140660_1 MMPL family K06994,K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 422.0
HKD2_k127_5140660_10 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.0000000000000002842 82.0
HKD2_k127_5140660_11 - - - - 0.0000001309 60.0
HKD2_k127_5140660_2 PFAM BioY K03523 - - 0.000000000000000000000000000000000000000000000000000000000000005454 222.0
HKD2_k127_5140660_3 basic membrane K07335 - - 0.000000000000000000000000000000000000000000000000000000000000009841 231.0
HKD2_k127_5140660_4 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000003722 213.0
HKD2_k127_5140660_5 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000002253 227.0
HKD2_k127_5140660_6 TPM domain K06872 - - 0.000000000000000000000000000000000000003872 158.0
HKD2_k127_5140660_7 - - - - 0.000000000000000000000000000000007038 145.0
HKD2_k127_5140660_8 Pentapeptide repeats (9 copies) - - - 0.00000000000000000000000000000002442 132.0
HKD2_k127_5140660_9 Cupin domain - - - 0.00000000000000000000006992 103.0
HKD2_k127_5185472_0 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 451.0
HKD2_k127_5185472_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 319.0
HKD2_k127_5185472_2 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001276 248.0
HKD2_k127_5185472_3 Belongs to the LDH MDH superfamily. LDH family K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000001487 184.0
HKD2_k127_522027_0 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 308.0
HKD2_k127_522027_1 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000002805 203.0
HKD2_k127_522027_2 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000007712 195.0
HKD2_k127_522027_3 catechol 1,2-dioxygenase - - - 0.00000000000000000000000000000000000000000002136 166.0
HKD2_k127_5236585_0 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000001596 173.0
HKD2_k127_5236585_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000001266 100.0
HKD2_k127_5236585_2 DNA polymerase alpha chain like domain - - - 0.0001926 51.0
HKD2_k127_5402359_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.785e-194 613.0
HKD2_k127_5402359_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 516.0
HKD2_k127_5402359_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 454.0
HKD2_k127_5402359_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 393.0
HKD2_k127_5402359_4 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 343.0
HKD2_k127_5402359_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000032 268.0
HKD2_k127_5402359_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000008042 264.0
HKD2_k127_5402359_7 PFAM histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000001373 135.0
HKD2_k127_5402359_8 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000002154 138.0
HKD2_k127_5407937_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2e-323 1006.0
HKD2_k127_5407937_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 315.0
HKD2_k127_5407937_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000267 267.0
HKD2_k127_5407937_3 - - - - 0.00000000000000000000000000000000000000198 153.0
HKD2_k127_5407937_4 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000002097 75.0
HKD2_k127_5421093_0 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 616.0
HKD2_k127_5421093_1 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008949 350.0
HKD2_k127_5424231_0 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 335.0
HKD2_k127_5424231_1 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000003133 233.0
HKD2_k127_5424231_2 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000004561 185.0
HKD2_k127_5424231_3 mRNA catabolic process - - - 0.0000000000000000000000000000000000000001954 157.0
HKD2_k127_5424231_4 TatD related DNase K07051 - - 0.00000000000000000000000000000915 128.0
HKD2_k127_5424231_5 DegV family - - - 0.00000000000000000000001122 111.0
HKD2_k127_5424231_6 Cupin 2, conserved barrel domain protein - - - 0.00000000001421 71.0
HKD2_k127_5424231_7 - - - - 0.00003749 48.0
HKD2_k127_5475875_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 350.0
HKD2_k127_5475875_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007507 268.0
HKD2_k127_5476741_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 602.0
HKD2_k127_5476741_1 PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738,K19515 - 1.2.7.5 0.0000000000000000000000001807 120.0
HKD2_k127_5515564_0 Aminotransferase class I and II K14155 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 525.0
HKD2_k127_5515564_1 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 517.0
HKD2_k127_5515564_2 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000037 221.0
HKD2_k127_5515564_3 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000001083 134.0
HKD2_k127_5515564_4 - - - - 0.0000000003672 62.0
HKD2_k127_5518642_0 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 374.0
HKD2_k127_5518642_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000794 164.0
HKD2_k127_5518642_2 MobA-like NTP transferase domain - - - 0.000000002194 60.0
HKD2_k127_5518642_3 Molecular chaperone. Has ATPase activity K04079 - - 0.0006987 52.0
HKD2_k127_5534706_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 437.0
HKD2_k127_5534706_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 319.0
HKD2_k127_5534706_2 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001364 275.0
HKD2_k127_5534706_3 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005547 261.0
HKD2_k127_5534706_4 UreE urease accessory protein, C-terminal domain K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000002296 240.0
HKD2_k127_5534706_5 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000003832 128.0
HKD2_k127_5547742_0 R3H domain - - - 6.391e-200 636.0
HKD2_k127_5547742_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 508.0
HKD2_k127_5547742_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 413.0
HKD2_k127_5547742_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002226 278.0
HKD2_k127_5547742_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000003874 224.0
HKD2_k127_5547742_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000008299 202.0
HKD2_k127_5547742_6 extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000411 158.0
HKD2_k127_5547742_7 nuclease activity K07460 - - 0.000000000000000000003563 100.0
HKD2_k127_5547742_8 Universal stress protein family - - - 0.000001312 55.0
HKD2_k127_5617232_0 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 5.825e-297 929.0
HKD2_k127_5617232_1 Telomere recombination K04656 - - 1.125e-234 742.0
HKD2_k127_5617232_2 hydrogenase large subunit K00436,K14126 - 1.12.1.2,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 552.0
HKD2_k127_5617232_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 350.0
HKD2_k127_5617232_4 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000001221 204.0
HKD2_k127_5617232_5 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000001365 143.0
HKD2_k127_5617232_6 Hydrogenase maturation protease K03605 - - 0.00000000000476 72.0
HKD2_k127_5617232_7 molybdopterin cofactor binding - - - 0.000000005857 58.0
HKD2_k127_5619807_0 Cys/Met metabolism PLP-dependent enzyme K01739,K01758 - 2.5.1.48,4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 429.0
HKD2_k127_5619807_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K12339,K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 388.0
HKD2_k127_5619807_2 TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein K02051,K15553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 381.0
HKD2_k127_5619807_3 PFAM binding-protein-dependent transport systems inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 326.0
HKD2_k127_5619807_4 Nitrite/Sulfite reductase ferredoxin-like half domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 323.0
HKD2_k127_5619807_5 PFAM ABC transporter related K02049 - - 0.0000000000000000000000001104 109.0
HKD2_k127_5619807_6 Uncharacterized small protein (DUF2292) - - - 0.0000009226 53.0
HKD2_k127_5623777_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.568e-295 929.0
HKD2_k127_5623777_1 arginine biosynthetic process via ornithine K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 578.0
HKD2_k127_5623777_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 553.0
HKD2_k127_5623777_3 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 474.0
HKD2_k127_5623777_4 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 417.0
HKD2_k127_5623777_5 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 412.0
HKD2_k127_5623777_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000002036 241.0
HKD2_k127_5623777_7 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000004223 222.0
HKD2_k127_5623777_8 Domain of unknown function (DUF370) K09777 - - 0.000000000000000000000001316 106.0
HKD2_k127_5623777_9 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000005376 66.0
HKD2_k127_5737868_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 3.789e-239 749.0
HKD2_k127_5737868_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000001352 180.0
HKD2_k127_5737868_2 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000004491 96.0
HKD2_k127_574884_0 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 403.0
HKD2_k127_574884_1 PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000007837 217.0
HKD2_k127_574884_2 ABC transporter substrate-binding protein K02035 - - 0.00000000000000000000000000000000000001191 160.0
HKD2_k127_574884_3 ADP-L-glycero-beta-D-manno-heptose biosynthetic process K00980 - 2.7.7.39 0.0000000000000000000000000000004783 129.0
HKD2_k127_574884_4 Homeodomain-like domain K03718 - - 0.000000000000004956 85.0
HKD2_k127_574884_5 helix_turn_helix ASNC type - - - 0.00000003897 64.0
HKD2_k127_574884_6 metallopeptidase activity K20276 - - 0.00003085 56.0
HKD2_k127_5788685_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.807e-242 763.0
HKD2_k127_5788685_1 Homocysteine biosynthesis enzyme, sulfur-incorporation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 417.0
HKD2_k127_5788685_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 331.0
HKD2_k127_5788685_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000001135 120.0
HKD2_k127_5798869_0 D-isomer specific 2-hydroxyacid dehydrogenase K12972 - 1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000002642 253.0
HKD2_k127_5798869_1 Transposase (IS116 IS110 IS902 family) - - - 0.0000000000000000000000000000000000000000000000000000000008305 212.0
HKD2_k127_5798869_2 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000005663 188.0
HKD2_k127_5798869_3 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000001324 150.0
HKD2_k127_5798869_4 COG3547 Transposase and inactivated derivatives - - - 0.0000001368 63.0
HKD2_k127_5837714_0 ABC transporter K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 348.0
HKD2_k127_5837714_1 molybdate abc transporter K02017,K02018,K15496 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 313.0
HKD2_k127_5837714_2 epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
HKD2_k127_5837714_3 3-oxo-5-alpha-steroid 4-dehydrogenase K12343 - 1.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000007195 256.0
HKD2_k127_5837714_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000001331 155.0
HKD2_k127_5837714_5 Nitrite and sulphite reductase 4Fe-4S - - - 0.0000000000000000000000000006391 116.0
HKD2_k127_5865823_0 Hemerythrin HHE cation binding domain protein K09155 - - 0.0000000000000000000000000000000000000000003313 173.0
HKD2_k127_5865823_1 Formylmethanofuran dehydrogenase, subunit e - - - 0.0000000000000000000000000000000002993 140.0
HKD2_k127_5865823_2 ATP-grasp domain - - - 0.0000000000000000000000000003463 122.0
HKD2_k127_5865823_3 conserved protein (DUF2249) K07322 - - 0.00000000000000000003967 103.0
HKD2_k127_5865823_4 Cytochrome D1 heme domain - - - 0.0000000008037 64.0
HKD2_k127_5865823_5 Transporter K02575 - - 0.0000000009374 59.0
HKD2_k127_6034481_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 447.0
HKD2_k127_6034481_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000006947 186.0
HKD2_k127_6035726_0 metal ion transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 369.0
HKD2_k127_6035726_1 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000001104 127.0
HKD2_k127_6062421_0 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 345.0
HKD2_k127_6062421_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 339.0
HKD2_k127_6062421_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000009843 267.0
HKD2_k127_6062421_3 MatE - - - 0.00000000000000000000000000000000000000000000000000000000000002344 226.0
HKD2_k127_6062421_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000007728 205.0
HKD2_k127_6062421_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000008464 207.0
HKD2_k127_6062421_6 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000002442 160.0
HKD2_k127_6062421_7 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000000008595 158.0
HKD2_k127_6091941_0 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 532.0
HKD2_k127_6091941_1 Iron dependent K03709 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 290.0
HKD2_k127_6091941_2 binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005086 247.0
HKD2_k127_6091941_3 - - - - 0.00000000000000000000000000003885 117.0
HKD2_k127_6091941_4 RF-1 domain K15034 - - 0.0000000002227 61.0
HKD2_k127_6106553_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 448.0
HKD2_k127_6106553_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003345 259.0
HKD2_k127_6106553_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000002476 81.0
HKD2_k127_6106553_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000001733 59.0
HKD2_k127_6129144_0 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 7.399e-223 704.0
HKD2_k127_6129144_1 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 578.0
HKD2_k127_6129144_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 543.0
HKD2_k127_6129144_3 nucleic acid phosphodiester bond hydrolysis K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 486.0
HKD2_k127_6129144_4 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 403.0
HKD2_k127_6129144_5 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 395.0
HKD2_k127_6129144_6 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 301.0
HKD2_k127_6129144_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 297.0
HKD2_k127_6129144_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003929 275.0
HKD2_k127_6129144_9 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000385 253.0
HKD2_k127_6153323_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 1.072e-233 737.0
HKD2_k127_6153323_1 Phosphofructokinase K21071 - 2.7.1.11,2.7.1.90 0.0000001646 54.0
HKD2_k127_6158643_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 440.0
HKD2_k127_6158643_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 308.0
HKD2_k127_6158643_2 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 294.0
HKD2_k127_6158643_3 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003228 282.0
HKD2_k127_6158643_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000005625 136.0
HKD2_k127_6158643_5 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000001104 117.0
HKD2_k127_6158643_6 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000004479 104.0
HKD2_k127_6158643_7 Protein of unknown function (DUF998) - - - 0.000000000000004663 85.0
HKD2_k127_6207281_0 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 357.0
HKD2_k127_6207281_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000005269 216.0
HKD2_k127_6207281_2 - - - - 0.00000000000000000000000000000001826 136.0
HKD2_k127_6207281_3 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000001061 90.0
HKD2_k127_6207281_4 - - - - 0.00000000000006072 76.0
HKD2_k127_6207281_5 Phospholipase_D-nuclease N-terminal - - - 0.0000000000003606 74.0
HKD2_k127_6207281_6 Diguanylate cyclase - - - 0.000000005184 63.0
HKD2_k127_6214224_0 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 323.0
HKD2_k127_6214224_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885,K15977 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000005023 241.0
HKD2_k127_624804_0 DNA ligase K01971 - 6.5.1.1 3.958e-239 766.0
HKD2_k127_624804_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005517 265.0
HKD2_k127_6285347_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 610.0
HKD2_k127_6285347_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 522.0
HKD2_k127_6285347_2 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 446.0
HKD2_k127_6285347_3 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 366.0
HKD2_k127_6285347_4 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 334.0
HKD2_k127_6285347_5 HEAT repeats - - - 0.000000000000000000000000000000000000000000000000000000000004666 218.0
HKD2_k127_6285347_6 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000003917 186.0
HKD2_k127_6285347_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000004167 161.0
HKD2_k127_6285347_8 Protein of unknown function, DUF255 K06888 - - 0.00000000000001797 77.0
HKD2_k127_6294578_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 396.0
HKD2_k127_6294578_2 Cupin 2, conserved barrel domain protein - - - 0.000000372 60.0
HKD2_k127_6294578_3 Restriction endonuclease K07448 - - 0.000004037 52.0
HKD2_k127_6299084_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 343.0
HKD2_k127_6299084_1 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000002934 127.0
HKD2_k127_6335981_0 HI0933-like protein K00313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009127 389.0
HKD2_k127_6335981_1 electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 375.0
HKD2_k127_6335981_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 292.0
HKD2_k127_6335981_3 electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 287.0
HKD2_k127_6335981_4 competence protein - - - 0.000000000000000000000000000000000000000000000000000000000001774 216.0
HKD2_k127_6335981_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000002109 161.0
HKD2_k127_6335981_6 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.0000000000000000000000000000000000004638 146.0
HKD2_k127_6335981_7 - - - - 0.000000000000000000000000000002936 121.0
HKD2_k127_6335981_8 COG2440 Ferredoxin-like protein K03855 - - 0.00000000000000000006223 93.0
HKD2_k127_6343394_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 318.0
HKD2_k127_6343394_1 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB - - - 0.00000000000000000000000000000000000000000000000000000001829 214.0
HKD2_k127_6343394_2 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB - - - 0.00000000000000000000000000004242 128.0
HKD2_k127_6369138_0 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003034 260.0
HKD2_k127_6369138_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003366 250.0
HKD2_k127_6369138_2 PFAM heat shock protein DnaJ domain protein K05516 - - 0.00000000000000000000000007913 113.0
HKD2_k127_6407951_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 413.0
HKD2_k127_6407951_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007374 377.0
HKD2_k127_6407951_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 303.0
HKD2_k127_6422526_0 Hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002998 250.0
HKD2_k127_6422526_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000004036 162.0
HKD2_k127_6422526_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000001255 121.0
HKD2_k127_6422526_3 Glyoxalase-like domain K05606 - 5.1.99.1 0.00000000000002277 80.0
HKD2_k127_6422526_4 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K00558,K13639,K13640 - 2.1.1.37 0.00000000000008934 78.0
HKD2_k127_6422526_5 Part of a membrane complex involved in electron transport K03616 - - 0.000006386 53.0
HKD2_k127_6449700_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 344.0
HKD2_k127_6449700_1 - - - - 0.00000000009389 66.0
HKD2_k127_6513548_0 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 321.0
HKD2_k127_6606560_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 354.0
HKD2_k127_6606560_1 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000001624 152.0
HKD2_k127_6606672_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K08070 - 1.3.1.74,3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 359.0
HKD2_k127_6606672_1 Transcriptional activator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 339.0
HKD2_k127_6606672_2 Zn-dependent alcohol dehydrogenases K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 340.0
HKD2_k127_6606672_3 PFAM LmbE family protein K18455 - 3.5.1.115 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 314.0
HKD2_k127_6606672_4 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000505 125.0
HKD2_k127_6606672_5 Major Facilitator Superfamily - - - 0.0000000000000000000001619 104.0
HKD2_k127_6642086_0 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 331.0
HKD2_k127_6642086_1 carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005076 271.0
HKD2_k127_6642086_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000134 260.0
HKD2_k127_6642086_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000009694 195.0
HKD2_k127_6642086_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000001112 154.0
HKD2_k127_6642086_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000000000001952 139.0
HKD2_k127_6642086_6 PFAM Acyl-CoA dehydrogenase - - - 0.00000000000000000000000000001342 123.0
HKD2_k127_6689672_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 422.0
HKD2_k127_6689672_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 404.0
HKD2_k127_6689672_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 351.0
HKD2_k127_6689672_3 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000000000000000000000000000000000002073 219.0
HKD2_k127_6689672_4 Belongs to the universal stress protein A family - - - 0.0000000000000000000000004644 111.0
HKD2_k127_6689672_5 - - - - 0.00000000000000000000006714 99.0
HKD2_k127_6766689_0 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 308.0
HKD2_k127_6766689_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000005278 186.0
HKD2_k127_6766689_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000005211 111.0
HKD2_k127_6766689_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388,K16885,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000001501 73.0
HKD2_k127_6766689_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0003393 47.0
HKD2_k127_6804218_0 Radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 404.0
HKD2_k127_6804218_1 CoA-transferase family III K07543 - 2.8.3.15 0.0000000000000000000000000000000000000000000002917 180.0
HKD2_k127_6804218_2 Helix-turn-helix domain - - - 0.000000004104 62.0
HKD2_k127_6804218_3 - - - - 0.0000001712 53.0
HKD2_k127_6814675_0 Molydopterin dinucleotide binding domain K07306,K07812 - 1.7.2.3,1.8.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 295.0
HKD2_k127_6814675_1 epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000127 111.0
HKD2_k127_6884348_0 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 374.0
HKD2_k127_6884348_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 348.0
HKD2_k127_6884348_2 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00000000000000000000000000000000000000000000000004332 192.0
HKD2_k127_6884348_3 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD - - - 0.0000000000000000000000000000000000000000000003944 181.0
HKD2_k127_6884348_4 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000000000006236 183.0
HKD2_k127_6884348_5 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000001305 174.0
HKD2_k127_6884348_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000002145 94.0
HKD2_k127_6884348_7 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0009869 44.0
HKD2_k127_6888632_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 513.0
HKD2_k127_6888632_1 PFAM HerA-ATP synthase, barrel domain - - - 0.000006764 51.0
HKD2_k127_6899807_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 551.0
HKD2_k127_6899807_1 Pyridine nucleotide-disulphide oxidoreductase K03387 - - 0.0000000000000000000000000000000000000000000000000000000000000000003313 236.0
HKD2_k127_6899807_2 Glutaredoxin - - - 0.000000000000000007915 85.0
HKD2_k127_6908475_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 503.0
HKD2_k127_6908475_1 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 332.0
HKD2_k127_6975336_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01740 - 2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 610.0
HKD2_k127_6975336_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 492.0
HKD2_k127_6975336_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000007038 246.0
HKD2_k127_7025659_0 Dehydrogenase E1 component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 425.0
HKD2_k127_7025659_1 overlaps another CDS with the same product name - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 417.0
HKD2_k127_7025659_2 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 329.0
HKD2_k127_7025659_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000001709 136.0
HKD2_k127_7027810_0 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB - - - 0.0000000000000000000000000000000000000000000000000000000000000001545 233.0
HKD2_k127_7027810_1 CoA-substrate-specific enzyme activase - - - 0.000000000000000000000000000000000000000000000000000004071 199.0
HKD2_k127_7027810_2 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000002598 169.0
HKD2_k127_7027810_3 BadF/BadG/BcrA/BcrD ATPase family K04114 - 1.3.7.8 0.000000152 55.0
HKD2_k127_7031891_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 499.0
HKD2_k127_7031891_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 379.0
HKD2_k127_7031891_2 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001888 276.0
HKD2_k127_7031891_3 Cupin 2, conserved barrel domain protein - - - 0.000001214 55.0
HKD2_k127_7051264_0 Two component transcriptional regulator, winged helix family K07669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005124 275.0
HKD2_k127_7051264_1 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002824 273.0
HKD2_k127_7051264_2 sh3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000003844 237.0
HKD2_k127_7067803_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000009295 217.0
HKD2_k127_7067803_1 response regulator - - - 0.000000000000001587 78.0
HKD2_k127_7075277_0 Citrate transporter K03893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 331.0
HKD2_k127_7075277_1 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000000000000005278 187.0
HKD2_k127_7075277_2 Resolvase, N terminal domain - - - 0.00000000000000000000000000005311 118.0
HKD2_k127_7092256_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000007524 223.0
HKD2_k127_7092256_1 UbiA prenyltransferase family K02548 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.00000000000000000000000000000000000000000003146 177.0
HKD2_k127_7092256_2 Cupin 2, conserved barrel domain protein - - - 0.0000000005085 66.0
HKD2_k127_7092256_3 Cupin 2, conserved barrel domain protein - - - 0.00000001019 63.0
HKD2_k127_718998_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 342.0
HKD2_k127_718998_1 ABC transporter permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 325.0
HKD2_k127_718998_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 320.0
HKD2_k127_718998_3 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 306.0
HKD2_k127_718998_4 Dolichyl-phosphate-mannose-protein mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000000000000000000000000000000000000000000000000000000000000001347 275.0
HKD2_k127_718998_5 Protein of unknown function (DUF1614) - - - 0.000000000000000000000000000000000000000000000000000000003272 203.0
HKD2_k127_718998_6 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000006239 213.0
HKD2_k127_718998_7 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.0000000000000000000000000000000000000000003554 167.0
HKD2_k127_7228236_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 326.0
HKD2_k127_7228236_1 Major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000001331 185.0
HKD2_k127_7228236_2 Domain of unknown function (DUF4382) - - - 0.00000000000000000000001453 115.0
HKD2_k127_7228236_3 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000001187 66.0
HKD2_k127_7293160_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 625.0
HKD2_k127_7293160_1 4Fe-4S dicluster domain K08358 - - 0.0000000000000000000000000000000000000000000000000000000000348 211.0
HKD2_k127_7370806_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000008203 247.0
HKD2_k127_7370806_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - - 0.0000000000000000000000004003 114.0
HKD2_k127_7370806_2 Helix-turn-helix domain - - - 0.000002613 56.0
HKD2_k127_7400984_0 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit K00335,K18331 - 1.12.1.3,1.6.5.3 1.675e-258 811.0
HKD2_k127_7400984_1 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000003222 168.0
HKD2_k127_7400984_2 formate dehydrogenase (NAD+) activity K00123,K05299 - 1.17.1.10,1.17.1.9 0.000000000000000000000000000000000000009999 147.0
HKD2_k127_7400984_3 domain, Protein - - - 0.0000000000000000000000000000000000005578 144.0
HKD2_k127_7400984_4 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000000000000000394 146.0
HKD2_k127_7401230_0 PFAM Cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000004812 186.0
HKD2_k127_7401230_1 MmgE/PrpD family - - - 0.00000000000000000000001425 109.0
HKD2_k127_7401230_2 4Fe-4S binding domain - - - 0.0000000000000000005112 87.0
HKD2_k127_7401230_3 Hemerythrin HHE cation binding domain K09155 - - 0.00000000000000002155 84.0
HKD2_k127_7401230_4 Nitrous oxide-stimulated promoter - - - 0.00000000000001982 79.0
HKD2_k127_7401230_5 binding domain protein - - - 0.0000000001335 64.0
HKD2_k127_7425284_0 Flavodoxin domain - - - 0.00000000000000000000000000000000000000000002831 172.0
HKD2_k127_7425284_1 Transmembrane secretion effector - - - 0.000000000000000002027 92.0
HKD2_k127_7430015_0 Glycosyltransferase family 20 K16055 - 2.4.1.15,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 577.0
HKD2_k127_7434792_0 4Fe-4S single cluster domain K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 465.0
HKD2_k127_7434792_1 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000473 273.0
HKD2_k127_7434792_2 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000007885 213.0
HKD2_k127_7451445_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000004732 220.0
HKD2_k127_7451445_1 Inositol monophosphatase family - - - 0.0000000000000000000000000000000000000000007529 169.0
HKD2_k127_7451445_2 CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.000000000000000000000000000004134 128.0
HKD2_k127_7451445_3 Protein of unknown function (DUF3090) - - - 0.00000000007246 70.0
HKD2_k127_7471956_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001325 273.0
HKD2_k127_7471956_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000007989 169.0
HKD2_k127_7471956_2 Serine threonine-protein phosphatase K04382 GO:0000164,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006417,GO:0006446,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0007166,GO:0007267,GO:0007623,GO:0008047,GO:0008150,GO:0008152,GO:0008287,GO:0009314,GO:0009416,GO:0009605,GO:0009628,GO:0009648,GO:0009649,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0010646,GO:0010647,GO:0010921,GO:0016043,GO:0016055,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019208,GO:0019211,GO:0019220,GO:0019222,GO:0019538,GO:0019888,GO:0022411,GO:0023051,GO:0023052,GO:0023056,GO:0030111,GO:0030177,GO:0030234,GO:0031323,GO:0031326,GO:0031399,GO:0032091,GO:0032268,GO:0032501,GO:0032535,GO:0032922,GO:0032984,GO:0032991,GO:0033554,GO:0034248,GO:0035303,GO:0035304,GO:0036211,GO:0036496,GO:0042578,GO:0042752,GO:0043085,GO:0043153,GO:0043170,GO:0043393,GO:0043412,GO:0043555,GO:0043558,GO:0043666,GO:0043933,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048511,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051174,GO:0051246,GO:0051336,GO:0051716,GO:0060070,GO:0060255,GO:0060828,GO:0065007,GO:0065008,GO:0065009,GO:0070262,GO:0071704,GO:0071840,GO:0072357,GO:0072542,GO:0080090,GO:0090066,GO:0090263,GO:0098772,GO:0140096,GO:0198738,GO:1901564,GO:1901567,GO:1902494,GO:1903293,GO:1904886,GO:1905114,GO:2000112 3.1.3.16 0.0000000000000000000000004689 114.0
HKD2_k127_7500297_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 309.0
HKD2_k127_7500297_1 periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003776 260.0
HKD2_k127_7500297_2 Xylose isomerase domain protein TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000001551 110.0
HKD2_k127_7525305_0 PFAM CobQ CobB MinD ParA nucleotide binding domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000118 267.0
HKD2_k127_7525305_1 Dihydroxyacetone kinase family - - - 0.0000000000000000000000000000000000000000006035 168.0
HKD2_k127_7525305_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000001208 139.0
HKD2_k127_7525305_3 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000001937 112.0
HKD2_k127_7545397_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 581.0
HKD2_k127_7545397_1 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 589.0
HKD2_k127_7545397_2 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 407.0
HKD2_k127_7545397_3 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000004322 129.0
HKD2_k127_7582594_0 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 303.0
HKD2_k127_7582594_1 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000003665 232.0
HKD2_k127_7582594_2 - - - - 0.000000000000009838 84.0
HKD2_k127_763617_0 SagB-type dehydrogenase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 309.0
HKD2_k127_763617_1 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000005814 142.0
HKD2_k127_763617_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000003522 83.0
HKD2_k127_7666161_0 Molydopterin dinucleotide binding domain K07306,K07812 - 1.7.2.3,1.8.5.3 0.0 1023.0
HKD2_k127_7666161_1 SNARE associated Golgi protein - - - 0.0000000000000000005202 90.0
HKD2_k127_7695700_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 334.0
HKD2_k127_7695700_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002756 280.0
HKD2_k127_7695700_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000005464 241.0
HKD2_k127_7695700_3 alpha/beta hydrolase fold - - - 0.0000000001596 70.0
HKD2_k127_7695700_5 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.0000000294 56.0
HKD2_k127_77731_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1444.0
HKD2_k127_77731_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 352.0
HKD2_k127_77731_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 282.0
HKD2_k127_77731_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000113 193.0
HKD2_k127_77731_4 Yqey-like protein K09117 - - 0.00000000000000000000000004819 115.0
HKD2_k127_77731_5 Ribosomal protein S21 K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000005711 74.0
HKD2_k127_777763_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 425.0
HKD2_k127_777763_1 Belongs to the enoyl-CoA hydratase isomerase family K15016 - 1.1.1.35,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 314.0
HKD2_k127_777763_2 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000000000000004293 148.0
HKD2_k127_7791151_0 NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 490.0
HKD2_k127_7791151_1 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 396.0
HKD2_k127_7791151_2 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000001966 183.0
HKD2_k127_7791151_3 - - - - 0.00000000000000000000000000000000002393 146.0
HKD2_k127_7791151_4 - - - - 0.00000000000000522 78.0
HKD2_k127_7791151_5 Hint domain - - - 0.00002673 55.0
HKD2_k127_7829822_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 461.0
HKD2_k127_7829822_1 Glucose dehydrogenase C-terminus K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000005064 141.0
HKD2_k127_7829822_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000005063 81.0
HKD2_k127_7829822_3 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042 - 2.3.1.157,2.7.7.23 0.000000000002367 70.0
HKD2_k127_785053_0 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 528.0
HKD2_k127_785053_1 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 520.0
HKD2_k127_785053_2 FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 492.0
HKD2_k127_785053_3 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001313 251.0
HKD2_k127_7853927_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 491.0
HKD2_k127_7853927_1 PFAM iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 456.0
HKD2_k127_7853927_2 Molydopterin dinucleotide binding domain K07306,K07812 - 1.7.2.3,1.8.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 392.0
HKD2_k127_7853927_3 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 323.0
HKD2_k127_7853927_4 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007435 277.0
HKD2_k127_7853927_5 domain protein - - - 0.00000000000000000000000000000000000000000001744 188.0
HKD2_k127_7853927_6 CoA binding domain - - - 0.000000000286 63.0
HKD2_k127_7853927_7 denitrification pathway K02569,K15876 - - 0.0002109 55.0
HKD2_k127_7925126_0 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 520.0
HKD2_k127_7925126_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 331.0
HKD2_k127_7925126_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 314.0
HKD2_k127_7925126_3 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 312.0
HKD2_k127_7925126_4 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000008826 239.0
HKD2_k127_7925126_5 Ethyl tert-butyl ether degradation EthD - - - 0.000000000006645 70.0
HKD2_k127_7925126_6 Cupin 2, conserved barrel domain protein - - - 0.00000000006488 68.0
HKD2_k127_7925126_7 - - - - 0.0000001984 57.0
HKD2_k127_7925126_8 - - - - 0.000004332 56.0
HKD2_k127_7948576_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00394 - 1.8.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 529.0
HKD2_k127_7948576_1 Metallo-beta-lactamase superfamily - - - 0.000000007065 63.0
HKD2_k127_7959949_0 Protein of unknown function (DUF1646) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 365.0
HKD2_k127_7959949_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000002506 227.0
HKD2_k127_7959949_2 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.0000000000000000000000004215 110.0
HKD2_k127_796954_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 571.0
HKD2_k127_796954_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 555.0
HKD2_k127_796954_2 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 0.00000000000000000000000000000000000000000000000005898 180.0
HKD2_k127_8012335_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1571.0
HKD2_k127_8012335_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 534.0
HKD2_k127_8012335_10 Major facilitator Superfamily K08177,K18326 - - 0.000000000000000000000000000000000000000000000000000000000000009464 220.0
HKD2_k127_8012335_11 Protein of unknown function (DUF1706) - - - 0.0000000000000000000000000000000000000002332 154.0
HKD2_k127_8012335_12 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.00000000000000000000000009001 117.0
HKD2_k127_8012335_13 PspC domain K03973 - - 0.0000000000000001098 81.0
HKD2_k127_8012335_14 - - - - 0.000000004149 59.0
HKD2_k127_8012335_15 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K07533 - 5.2.1.8 0.00000007328 64.0
HKD2_k127_8012335_16 - - - - 0.0000004618 53.0
HKD2_k127_8012335_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 524.0
HKD2_k127_8012335_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 505.0
HKD2_k127_8012335_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 466.0
HKD2_k127_8012335_5 amino acid binding K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 429.0
HKD2_k127_8012335_6 GTP cyclohydrolase I activity K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000001071 266.0
HKD2_k127_8012335_7 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000008467 258.0
HKD2_k127_8012335_8 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001833 252.0
HKD2_k127_8012335_9 Iron-containing alcohol dehydrogenase K17067 - 1.1.99.37,1.2.98.1 0.0000000000000000000000000000000000000000000000000000000000000000007307 241.0
HKD2_k127_8018042_0 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 361.0
HKD2_k127_8018042_1 Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 305.0
HKD2_k127_8018042_2 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000007532 239.0
HKD2_k127_8018042_3 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000004187 177.0
HKD2_k127_8018042_4 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000001322 166.0
HKD2_k127_8018042_5 Enoyl-(Acyl carrier protein) reductase K07535 - - 0.0000000000000000000000000000000000000000003819 167.0
HKD2_k127_8018042_6 Uncharacterised ArCR, COG2043 - - - 0.000000000000005499 85.0
HKD2_k127_8029797_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 477.0
HKD2_k127_8029797_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 338.0
HKD2_k127_8029797_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005003 254.0
HKD2_k127_8029797_4 - - - - 0.00002466 51.0
HKD2_k127_8057571_0 Dehydrogenase K00005 - 1.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 438.0
HKD2_k127_8057571_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002493 281.0
HKD2_k127_8057571_2 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000856 224.0
HKD2_k127_8057571_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000004986 186.0
HKD2_k127_8057571_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000001134 127.0
HKD2_k127_8057571_5 Uncharacterised ArCR, COG2043 - - - 0.000000000005956 71.0
HKD2_k127_8084322_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 344.0
HKD2_k127_8084322_1 PFAM Iron-containing alcohol dehydrogenase K17067 - 1.1.99.37,1.2.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 294.0
HKD2_k127_8084322_2 PFAM Iron-containing alcohol dehydrogenase K17067 - 1.1.99.37,1.2.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004931 277.0
HKD2_k127_8084322_3 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001082 246.0
HKD2_k127_8084322_4 Protein of unknown function DUF126 K09128 - - 0.0000000000000000000000000000000000000000000000000000005209 199.0
HKD2_k127_8084322_5 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000006619 72.0
HKD2_k127_8085630_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.409e-308 956.0
HKD2_k127_8085630_1 nitronate monooxygenase activity K00088,K00459 - 1.1.1.205,1.13.12.16 1.9e-296 914.0
HKD2_k127_8085630_10 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 371.0
HKD2_k127_8085630_11 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001842 267.0
HKD2_k127_8085630_12 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004542 261.0
HKD2_k127_8085630_13 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003301 259.0
HKD2_k127_8085630_14 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006965 261.0
HKD2_k127_8085630_15 PFAM ROK family protein K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000006039 254.0
HKD2_k127_8085630_16 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000006297 181.0
HKD2_k127_8085630_17 DRTGG domain protein K06873 - - 0.0000000000000000000000000000008505 137.0
HKD2_k127_8085630_18 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000001001 117.0
HKD2_k127_8085630_19 FAD dependent oxidoreductase K07007 - - 0.000000000000001237 77.0
HKD2_k127_8085630_2 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 2.084e-284 886.0
HKD2_k127_8085630_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 1.438e-210 666.0
HKD2_k127_8085630_4 Carbohydrate phosphorylase K00688 - 2.4.1.1 1.989e-204 650.0
HKD2_k127_8085630_5 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 556.0
HKD2_k127_8085630_6 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 527.0
HKD2_k127_8085630_7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 507.0
HKD2_k127_8085630_8 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 458.0
HKD2_k127_8085630_9 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 378.0
HKD2_k127_8136014_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 8.755e-197 628.0
HKD2_k127_826177_0 Protein of unknown function (DUF521) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000706 278.0
HKD2_k127_826177_1 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000002597 241.0
HKD2_k127_827433_0 ABC transporter K02017,K06857 - 3.6.3.29,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 334.0
HKD2_k127_827433_1 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004145 276.0
HKD2_k127_827433_10 Thioredoxin-like - - - 0.00000000000000000000000000000007643 130.0
HKD2_k127_827433_11 Trm112p-like protein - - - 0.00000000000000001425 86.0
HKD2_k127_827433_2 Bacterial extracellular solute-binding protein K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006217 267.0
HKD2_k127_827433_3 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000003645 241.0
HKD2_k127_827433_4 4Fe-4S single cluster domain K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000002276 229.0
HKD2_k127_827433_5 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000003599 180.0
HKD2_k127_827433_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000009182 158.0
HKD2_k127_827433_7 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K09007,K13940,K17488 - 2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25 0.0000000000000000000000000000000000000008578 154.0
HKD2_k127_827433_8 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000003361 147.0
HKD2_k127_827433_9 - - - - 0.000000000000000000000000000000000172 135.0
HKD2_k127_8283353_0 Conserved carboxylase domain K01960 - 6.4.1.1 3.013e-246 773.0
HKD2_k127_8283353_1 Biotin carboxylase C-terminal domain - - - 1.69e-217 685.0
HKD2_k127_8283353_2 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000001437 159.0
HKD2_k127_8283353_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000005617 138.0
HKD2_k127_8319642_0 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000245 286.0
HKD2_k127_8319642_1 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000000000000002174 230.0
HKD2_k127_8319642_2 Putative stress-induced transcription regulator - - - 0.000000000000000000000000000000000000000002823 162.0
HKD2_k127_8319642_3 - - - - 0.000000000000000000000000000000000000000008661 160.0
HKD2_k127_8319642_4 Cupin 2, conserved barrel domain protein - - - 0.000000000002873 74.0
HKD2_k127_8383850_0 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002203 280.0
HKD2_k127_8383850_1 Iron permease FTR1 K07243 - - 0.0000000000000000000000000000000000000000000000000000001463 203.0
HKD2_k127_8383850_2 Glucose inhibited division protein A - - - 0.0000000000000000000000000000000000000000000000000000164 198.0
HKD2_k127_8383850_3 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000007198 192.0
HKD2_k127_8383850_4 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000004725 179.0
HKD2_k127_8383850_5 TIGRFAM thiamine biosynthesis protein ThiS K03154 - - 0.00002609 49.0
HKD2_k127_8418194_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.094e-248 787.0
HKD2_k127_8418194_1 Elongator protein 3, MiaB family, Radical SAM - - - 7.574e-197 627.0
HKD2_k127_8418194_2 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008676 451.0
HKD2_k127_8418194_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 414.0
HKD2_k127_8418194_4 DeoC/LacD family aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009976 406.0
HKD2_k127_8418194_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000006208 248.0
HKD2_k127_8418194_6 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000002306 180.0
HKD2_k127_8418194_7 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000377 70.0
HKD2_k127_8449845_0 FAD linked oxidases, C-terminal domain - - - 1.475e-237 747.0
HKD2_k127_8449845_1 Transcriptional regulator, arsR family - - - 0.00000000000000007318 83.0
HKD2_k127_845559_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 431.0
HKD2_k127_845559_1 PFAM Alpha beta hydrolase fold-3 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 332.0
HKD2_k127_845559_2 Phage tail protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001098 265.0
HKD2_k127_845559_3 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001739 253.0
HKD2_k127_845559_4 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000008752 96.0
HKD2_k127_845559_5 - - - - 0.000000007847 58.0
HKD2_k127_845559_6 PFAM Integrase catalytic region K07497 - - 0.0000002017 53.0
HKD2_k127_8456140_0 FecR protein - - - 0.0 1058.0
HKD2_k127_8456140_1 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 553.0
HKD2_k127_8461541_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 314.0
HKD2_k127_8461541_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003773 283.0
HKD2_k127_8461541_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006939 277.0
HKD2_k127_8461541_3 PFAM Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000169 217.0
HKD2_k127_8461541_4 PFAM Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000001148 194.0
HKD2_k127_851703_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 591.0
HKD2_k127_851703_1 CoA-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 366.0
HKD2_k127_855044_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 402.0
HKD2_k127_855044_1 Peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002049 302.0
HKD2_k127_855044_2 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000004912 144.0
HKD2_k127_8588161_0 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 400.0
HKD2_k127_8588161_1 Cysteine-rich domain - - - 0.00000000000000000000000000000000119 136.0
HKD2_k127_8596278_0 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 551.0
HKD2_k127_8596278_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000008231 173.0
HKD2_k127_8596278_2 Protein of unknown function DUF72 - - - 0.0000000000001179 71.0
HKD2_k127_8636634_0 Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 565.0
HKD2_k127_8636634_1 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
HKD2_k127_8636634_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - 0.0000000000000000000000000000008402 130.0
HKD2_k127_8636634_3 glutaredoxin-like protein, YruB-family - - - 0.000000000000000001767 86.0
HKD2_k127_8636634_4 Uncharacterised ArCR, COG2043 - - - 0.000000000000001371 85.0
HKD2_k127_8667782_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001751 239.0
HKD2_k127_8667782_1 Iron-sulfur cluster-binding protein K00782 - - 0.00000000000000000000000000000000000000000000000000000000000000381 219.0
HKD2_k127_8667782_2 Glycosyl transferase 4-like domain K15521 - 2.4.1.250 0.00000000000000000000000000000000000000000003786 166.0
HKD2_k127_8668789_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 1.851e-209 669.0
HKD2_k127_8668789_1 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001754 269.0
HKD2_k127_871771_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 393.0
HKD2_k127_871771_1 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 359.0
HKD2_k127_871771_2 imidazoleglycerol-phosphate dehydratase activity K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004295 280.0
HKD2_k127_871771_3 Pterin binding enzyme K00796 - 2.5.1.15 0.0000000000000000000000000000000000000001604 157.0
HKD2_k127_8730882_0 Belongs to the ClpA ClpB family K03696 - - 0.0 1140.0
HKD2_k127_8730882_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.841e-211 663.0
HKD2_k127_8730882_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 336.0
HKD2_k127_8730882_3 NUDIX domain - - - 0.000000000000000000000000000000000000006161 153.0
HKD2_k127_8730882_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000008047 153.0
HKD2_k127_8730882_5 MerR HTH family regulatory protein K13640 - - 0.000000000000000000000000000004869 122.0
HKD2_k127_8734576_0 TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 459.0
HKD2_k127_8734576_1 Zn-dependent alcohol dehydrogenases K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 353.0
HKD2_k127_8734576_2 drug transmembrane transporter activity - - - 0.00000000000000000000000000000006416 134.0
HKD2_k127_8739990_0 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 368.0
HKD2_k127_8739990_1 Belongs to the ABC transporter superfamily K10823 - - 0.000000000000000000000000000000000000000000000000000000006365 201.0
HKD2_k127_8739990_2 - - - - 0.00000001183 63.0
HKD2_k127_8772580_0 LacY proton/sugar symporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 357.0
HKD2_k127_8772580_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000009495 260.0
HKD2_k127_8772580_2 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000003537 218.0
HKD2_k127_8772580_3 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000006038 187.0
HKD2_k127_8772580_4 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000004422 180.0
HKD2_k127_8772580_5 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000003024 175.0
HKD2_k127_878843_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002198 267.0
HKD2_k127_878843_1 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000004636 193.0
HKD2_k127_878843_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K05555 - - 0.00000000000000000000000000000000001071 147.0
HKD2_k127_8833873_0 PFAM ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 548.0
HKD2_k127_8833873_1 Carboxylesterase family K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 419.0
HKD2_k127_8833873_2 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 353.0
HKD2_k127_8833873_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000002379 162.0
HKD2_k127_8833873_4 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000001098 119.0
HKD2_k127_8836677_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 534.0
HKD2_k127_8836677_1 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 422.0
HKD2_k127_8836677_2 - K03975 - - 0.00000000000000000000000001091 120.0
HKD2_k127_8836677_3 helix_turn_helix, mercury resistance K13640 - - 0.000000000000000000009633 98.0
HKD2_k127_8877808_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000118 254.0
HKD2_k127_8877808_1 KR domain K10780 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.104 0.00000000000172 68.0
HKD2_k127_8877808_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000002019 59.0
HKD2_k127_8941440_0 Radical SAM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 362.0
HKD2_k127_8941440_1 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000000000000000000003487 141.0
HKD2_k127_8941440_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000003035 112.0
HKD2_k127_8941440_3 Domain of unknown function (DUF4870) - - - 0.0000000000000000000000009378 116.0
HKD2_k127_8941440_4 response regulator K07689 - - 0.000000000000000000000005006 105.0
HKD2_k127_8941440_5 - - - - 0.0009359 48.0
HKD2_k127_8945724_0 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 328.0
HKD2_k127_8945724_1 PFAM Carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000001973 143.0
HKD2_k127_8945724_2 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.0000000000000000000000005772 109.0
HKD2_k127_8945724_3 AMP binding - - - 0.00000000000005077 73.0
HKD2_k127_8978882_0 Glutamine cyclotransferase K00683 - 2.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002148 278.0
HKD2_k127_8978882_1 PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738,K19515 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000006516 258.0
HKD2_k127_8978882_2 Rubrerythrin - - - 0.000000000000000000000000000000003035 134.0
HKD2_k127_8978882_3 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000002977 110.0
HKD2_k127_899514_0 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000004224 173.0
HKD2_k127_899514_1 PFAM 2-hydroxyglutaryl-CoA dehydratase D-component - - - 0.0000000000000000000000000000000000001698 156.0
HKD2_k127_9020432_0 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000000000001421 160.0
HKD2_k127_9020432_1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000000000000000000000000177 139.0
HKD2_k127_9020432_2 - - - - 0.000000000004356 68.0
HKD2_k127_9020432_3 Putative auto-transporter adhesin, head GIN domain - - - 0.0007985 50.0
HKD2_k127_9058387_0 leucyl-tRNA aminoacylation K01869 - 6.1.1.4 0.0 1129.0
HKD2_k127_9058387_1 Fungal trichothecene efflux pump (TRI12) - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 548.0
HKD2_k127_9058387_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000009151 262.0
HKD2_k127_9058387_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000001318 211.0
HKD2_k127_9058387_4 Colicin V production protein K03558 - - 0.000000000000000000000000000000000002409 144.0
HKD2_k127_9058387_5 Short C-terminal domain K08982 - - 0.00000000000006544 74.0
HKD2_k127_9058387_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000008158 60.0
HKD2_k127_9135692_0 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.000000000000000000000000000000000000005771 149.0
HKD2_k127_9135692_1 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0000000000000000000000000000000003642 141.0
HKD2_k127_9135692_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.00000005233 59.0
HKD2_k127_9138405_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 1.261e-244 775.0
HKD2_k127_9138405_1 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 357.0
HKD2_k127_9138405_2 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 332.0
HKD2_k127_9138405_3 DNA recombination-mediator protein A K04096 - - 0.00000000000000000006276 92.0
HKD2_k127_9166772_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 7.348e-225 711.0
HKD2_k127_9166772_1 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000000000000000000000475 185.0
HKD2_k127_9173820_0 SERine Proteinase INhibitors K13963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 451.0
HKD2_k127_9173820_1 Electron transfer flavoprotein K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000005677 238.0
HKD2_k127_9176495_0 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 332.0
HKD2_k127_9176495_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000006238 242.0
HKD2_k127_9176495_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000002059 179.0
HKD2_k127_9176495_3 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000001973 144.0
HKD2_k127_9176495_4 4Fe-4S dicluster domain - - - 0.000000000000000001585 92.0
HKD2_k127_9176495_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.000000000000000006597 91.0
HKD2_k127_9177927_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1159.0
HKD2_k127_9177927_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1034.0
HKD2_k127_9177927_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 485.0
HKD2_k127_9177927_3 DNA polymerase X family K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 389.0
HKD2_k127_9218302_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 529.0
HKD2_k127_9218302_1 Glycosyl transferases group 1 K08256 - 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 447.0
HKD2_k127_9218302_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 392.0
HKD2_k127_9218302_3 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 370.0
HKD2_k127_9218302_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000003246 254.0
HKD2_k127_9218302_5 PFAM Dak phosphatase K07030 - - 0.00000000000000000000000000000000000000000000000000000000000000000001138 245.0
HKD2_k127_9218302_6 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000002613 172.0
HKD2_k127_9218302_7 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000008377 113.0
HKD2_k127_9330799_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1e-323 1007.0
HKD2_k127_9330799_1 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 542.0
HKD2_k127_9330799_2 Metalloenzyme superfamily K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 460.0
HKD2_k127_9330799_3 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000005319 226.0
HKD2_k127_9330799_4 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000005682 214.0
HKD2_k127_9330799_5 Universal stress protein family - - - 0.0002103 45.0
HKD2_k127_9363195_0 HMGL-like K02594 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 470.0
HKD2_k127_9363195_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 379.0
HKD2_k127_9382336_0 Major facilitator Superfamily K08168 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 412.0
HKD2_k127_9382336_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000109 104.0
HKD2_k127_9382336_2 ABC transporter transmembrane region K06147 - - 0.00000000000823 67.0
HKD2_k127_9414419_0 Ferric uptake regulator family K03711 - - 0.00000000000000000000000000000000000000000001525 165.0
HKD2_k127_9414419_1 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000001233 170.0
HKD2_k127_9414419_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000001709 156.0
HKD2_k127_9414419_3 Cobalt transport protein K02008 - - 0.0000000000000000002042 95.0
HKD2_k127_9414419_4 MarR family - - - 0.0000000000007408 75.0
HKD2_k127_9418150_0 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000002813 227.0
HKD2_k127_9418150_1 MmgE/PrpD family - - - 0.000000000000000000000000001182 126.0
HKD2_k127_9425626_0 PFAM ApbE family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000009304 230.0
HKD2_k127_9425626_1 Homocysteine biosynthesis enzyme, sulfur-incorporation - - - 0.0000000000000000000000000000000000000000000000000000000001598 206.0
HKD2_k127_9425626_2 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000000008346 207.0
HKD2_k127_9425626_3 NIL - - - 0.00000000000000000000000000000000000000000000000001034 183.0
HKD2_k127_9425626_4 histidine kinase A domain protein - - - 0.000000000000000000000000000000001949 141.0
HKD2_k127_9519603_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002213 257.0
HKD2_k127_9519603_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000006146 185.0
HKD2_k127_9519603_2 Nitroreductase family - - - 0.0000000007431 61.0
HKD2_k127_9528418_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 414.0
HKD2_k127_9528418_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 334.0
HKD2_k127_9528418_2 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000002053 233.0
HKD2_k127_9528418_3 MMPL family - - - 0.000000000000000000000009362 112.0
HKD2_k127_9528418_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000002263 70.0
HKD2_k127_9537621_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000001784 213.0
HKD2_k127_9537621_1 3-demethylubiquinone-9 3-O-methyltransferase activity K06219 - - 0.00000000000000000000000000000000000000000000000001037 192.0
HKD2_k127_9537621_2 Anthranilate synthase component I, N terminal region K01657,K01665,K13950 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000007517 175.0
HKD2_k127_9568858_0 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 411.0
HKD2_k127_9568858_1 E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 339.0
HKD2_k127_9568858_2 Transketolase, pyrimidine binding domain K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 299.0
HKD2_k127_9568858_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001272 260.0
HKD2_k127_9568858_4 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000002949 212.0
HKD2_k127_9568858_5 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000004629 201.0
HKD2_k127_959862_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 8.073e-213 669.0
HKD2_k127_959862_1 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 343.0
HKD2_k127_959862_2 Alpha/beta hydrolase family K06889,K07397 - - 0.00000000000000000000000000000000000000000000000000000000004129 215.0
HKD2_k127_959862_3 HMGL-like K02594 - 2.3.3.14 0.00000000000000000000000000000000000000000000001617 172.0
HKD2_k127_959862_4 MFS_1 like family - - - 0.00000000000000000000000000000000000001681 162.0
HKD2_k127_959862_5 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.000000000000000000000002122 102.0
HKD2_k127_959862_6 Dodecin K09165 - - 0.000000000000000000001312 96.0
HKD2_k127_959862_7 Psort location CytoplasmicMembrane, score 9.46 K09793 - - 0.000000000000000000004961 98.0
HKD2_k127_959862_8 Cupin 2, conserved barrel domain protein - - - 0.00003609 55.0
HKD2_k127_9609030_0 AMP-binding enzyme K01897 - 6.2.1.3 3.198e-302 938.0
HKD2_k127_9609030_1 AMP-binding enzyme K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 484.0
HKD2_k127_9609030_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 464.0
HKD2_k127_9609030_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 433.0
HKD2_k127_9609030_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 412.0
HKD2_k127_9609030_5 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008137 280.0
HKD2_k127_9609030_6 Type IV leader peptidase family K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000001879 221.0
HKD2_k127_9609030_7 type IV pilus modification protein PilV - - - 0.000000000002318 72.0
HKD2_k127_9609030_8 - - - - 0.0002125 53.0
HKD2_k127_962334_0 protein, phage tail-like region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002263 274.0
HKD2_k127_9640394_0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000075 241.0
HKD2_k127_9640394_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000001257 186.0
HKD2_k127_9640394_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000001324 150.0
HKD2_k127_9694581_0 succinate dehydrogenase K00394 - 1.8.99.2 2.202e-227 722.0
HKD2_k127_9694581_1 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000001135 167.0
HKD2_k127_9694581_2 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.000000000000000000000000000000003558 138.0
HKD2_k127_9694581_3 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000149 101.0
HKD2_k127_9694581_4 Membrane-bound metal-dependent hydrolase - - - 0.000000000000002702 79.0
HKD2_k127_9712216_0 iron hydrogenase, small subunit K00336,K18332 - 1.12.1.3,1.6.5.3 9.901e-229 721.0
HKD2_k127_9712216_1 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331 - 1.12.1.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002343 274.0
HKD2_k127_9712216_2 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334,K18330 - 1.12.1.3,1.6.5.3 0.00000000000000000000000000000000000000000000002545 175.0
HKD2_k127_9712216_3 - - - - 0.0000000000000000004711 94.0
HKD2_k127_9712216_4 GyrI-like small molecule binding domain - - - 0.0000006066 51.0
HKD2_k127_9724186_0 Belongs to the glycosyl hydrolase 57 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 488.0
HKD2_k127_9724186_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.000000000000000000000000000000009083 132.0
HKD2_k127_9724186_3 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000001419 86.0
HKD2_k127_9724186_4 Domain of unknown function (DUF1925) K22451 - 2.4.1.25 0.0000000000009695 80.0
HKD2_k127_9748205_0 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 607.0
HKD2_k127_9748205_1 Fungal trichothecene efflux pump (TRI12) - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 447.0
HKD2_k127_9748205_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000001432 253.0
HKD2_k127_9748205_3 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000001871 244.0
HKD2_k127_9748205_4 Smr domain - - - 0.00000000000000000000000000000000002158 138.0
HKD2_k127_9748205_5 Glyoxalase-like domain K01759,K05606 - 4.4.1.5,5.1.99.1 0.000000000000000000814 91.0
HKD2_k127_9748205_6 - - - - 0.0000000375 64.0
HKD2_k127_9878296_0 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 378.0
HKD2_k127_9878296_1 SPFH domain / Band 7 family - - - 0.000000000000000000000000000000000000000000001021 173.0
HKD2_k127_9933628_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007711 466.0
HKD2_k127_9933628_1 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 367.0
HKD2_k127_9933628_2 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000001899 198.0
HKD2_k127_9933628_3 Methylates ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000001107 182.0
HKD2_k127_9933628_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000007289 124.0
HKD2_k127_9933628_5 AMP binding - - - 0.0000000000000000000002068 104.0
HKD2_k127_9976622_0 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000312 271.0
HKD2_k127_9976622_1 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004022 265.0
HKD2_k127_9976622_2 Branched-chain amino acid transport system / permease component - - - 0.000000001292 61.0
HKD2_k127_9980329_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 469.0
HKD2_k127_9980329_1 Peptidase MA superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 330.0
HKD2_k127_9980329_2 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 292.0
HKD2_k127_9980329_3 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000008015 153.0
HKD2_k127_9994258_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.248e-249 784.0
HKD2_k127_9994258_1 Homeodomain-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 353.0
HKD2_k127_9994258_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000721 234.0
HKD2_k127_9994258_3 Sodium/hydrogen exchanger family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000002007 234.0
HKD2_k127_9994258_4 CorA-like Mg2+ transporter protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000003418 231.0