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Overview

ID MAG01823
Name HKD2_bin.84
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class HRBIN11
Order JAKEFK01
Family JAKEFK01
Genus
Species
Assembly information
Completeness (%) 93.09
Contamination (%) 0.09
GC content (%) 62.0
N50 (bp) 10,768
Genome size (bp) 4,875,129

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3955

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10039037_0 Amidohydrolase family - - - 3.832e-219 694.0
HKD2_k127_10039037_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 495.0
HKD2_k127_10039037_2 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 297.0
HKD2_k127_10039037_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 303.0
HKD2_k127_10039037_4 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004654 282.0
HKD2_k127_10039037_5 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000003163 172.0
HKD2_k127_10039037_6 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000005274 177.0
HKD2_k127_10039037_7 PFAM Glycosyl transferase, group 1 K19424 - - 0.00000000000000000194 97.0
HKD2_k127_10039037_8 ABC transporter K01989 - - 0.000001781 58.0
HKD2_k127_10052309_0 A-macroglobulin complement component - - - 3.638e-195 671.0
HKD2_k127_10052309_1 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005501 626.0
HKD2_k127_10052309_2 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000001309 224.0
HKD2_k127_10052309_3 cytochrome - - - 0.00000000000000000000000000000000000000000000000005617 183.0
HKD2_k127_10052309_4 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000008588 139.0
HKD2_k127_10052309_5 Rhomboid family - - - 0.000000000000000000000000000000004711 136.0
HKD2_k127_10052309_6 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000003857 111.0
HKD2_k127_10052309_7 RNA recognition motif - - - 0.0000000000000000000000001643 109.0
HKD2_k127_10052309_8 Winged helix DNA-binding domain - - - 0.000000000000000000001072 98.0
HKD2_k127_10052309_9 - - - - 0.0008695 50.0
HKD2_k127_10095662_0 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000000000000000001252 194.0
HKD2_k127_10095662_1 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.0000000000000007663 79.0
HKD2_k127_10095662_2 Protein kinase domain - - - 0.000000004418 68.0
HKD2_k127_10099752_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 4.374e-243 766.0
HKD2_k127_10099752_1 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 404.0
HKD2_k127_10099752_10 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0008195 42.0
HKD2_k127_10099752_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 368.0
HKD2_k127_10099752_3 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 289.0
HKD2_k127_10099752_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000004424 259.0
HKD2_k127_10099752_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000001482 262.0
HKD2_k127_10099752_6 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000002255 230.0
HKD2_k127_10099752_7 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000001641 184.0
HKD2_k127_10099752_8 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000002489 165.0
HKD2_k127_10099752_9 Protein conserved in bacteria - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.00003553 56.0
HKD2_k127_10108170_0 choline dehydrogenase activity - - - 1.403e-245 764.0
HKD2_k127_10108170_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000581 222.0
HKD2_k127_10108170_2 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000002194 229.0
HKD2_k127_10108170_3 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000001502 164.0
HKD2_k127_10108170_4 DinB family - - - 0.000000000000000000000000000004116 127.0
HKD2_k127_10108170_5 FtsZ-dependent cytokinesis - - - 0.00000000000000000000000000137 121.0
HKD2_k127_10115659_0 Sodium/calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 419.0
HKD2_k127_10115659_1 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 370.0
HKD2_k127_10115659_2 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000001823 237.0
HKD2_k127_10115659_3 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000266 127.0
HKD2_k127_10115659_4 - - - - 0.0000000000000000001659 96.0
HKD2_k127_10147387_0 peptidyl-tyrosine sulfation - - - 2.248e-203 709.0
HKD2_k127_10147387_1 Vault protein inter-alpha-trypsin domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 454.0
HKD2_k127_10147387_2 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 364.0
HKD2_k127_10147387_3 Stage II sporulation protein K06381 - - 0.0000000000000000000000000003858 130.0
HKD2_k127_10147387_5 Stage II sporulation D domain protein K06381 - - 0.0000000000000000000000005772 117.0
HKD2_k127_10147387_6 Encoded by - - - 0.00000004056 64.0
HKD2_k127_10147387_7 PFAM BNR Asp-box repeat - - - 0.000007626 57.0
HKD2_k127_10173593_0 transmembrane transporter activity K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 599.0
HKD2_k127_10173593_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000003798 156.0
HKD2_k127_10173593_2 Outer membrane efflux protein K15725 - - 0.000001836 60.0
HKD2_k127_1027243_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.621e-250 793.0
HKD2_k127_1027243_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 414.0
HKD2_k127_1027243_2 Fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000000000000000009126 226.0
HKD2_k127_1027243_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000003762 206.0
HKD2_k127_1027243_4 domain, Protein - - - 0.000000000000002205 85.0
HKD2_k127_1108472_0 Protein of unknown function (DUF1349) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 420.0
HKD2_k127_1108472_1 Abc transporter K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 298.0
HKD2_k127_1108472_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000007791 173.0
HKD2_k127_1108472_3 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000008675 117.0
HKD2_k127_1108472_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000189 50.0
HKD2_k127_1112438_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 420.0
HKD2_k127_1112438_1 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 380.0
HKD2_k127_1112438_2 Carboxypeptidase regulatory-like domain - - - 0.00000000002054 70.0
HKD2_k127_1167181_0 Transport of potassium into the cell K03549 - - 7.073e-231 731.0
HKD2_k127_1167181_1 ATP-dependent helicase HrpB K03579 - 3.6.4.13 1.638e-198 646.0
HKD2_k127_1167181_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005965 587.0
HKD2_k127_1167181_3 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 548.0
HKD2_k127_1167181_4 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 316.0
HKD2_k127_1167181_5 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000001558 121.0
HKD2_k127_1167181_6 Serine aminopeptidase, S33 K06889 - - 0.00001342 56.0
HKD2_k127_1167280_0 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 475.0
HKD2_k127_1167280_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 456.0
HKD2_k127_1167280_10 DNA-binding transcription factor activity - - - 0.0000000000000000000000005813 108.0
HKD2_k127_1167280_11 - - - - 0.00000002066 61.0
HKD2_k127_1167280_12 - - - - 0.00008383 51.0
HKD2_k127_1167280_2 TIGRFAM glycerol-3-phosphate dehydrogenase, anaerobic, C subunit K00113 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 379.0
HKD2_k127_1167280_3 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001812 252.0
HKD2_k127_1167280_4 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000006849 227.0
HKD2_k127_1167280_5 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000004454 166.0
HKD2_k127_1167280_6 AhpC/TSA family - - - 0.000000000000000000000000000000000000000002148 160.0
HKD2_k127_1167280_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000001313 136.0
HKD2_k127_1167280_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000002466 125.0
HKD2_k127_1167280_9 belongs to the Fur family K03711,K09825 - - 0.0000000000000000000000000001959 118.0
HKD2_k127_1167331_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000002386 139.0
HKD2_k127_1167331_1 Putative zinc-finger - - - 0.00000001626 66.0
HKD2_k127_1167331_2 Putative adhesin - - - 0.00000008666 64.0
HKD2_k127_1173051_0 Serine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 449.0
HKD2_k127_1173051_1 Aspartyl protease - - - 0.00000001436 58.0
HKD2_k127_1173970_0 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 419.0
HKD2_k127_1173970_1 beta-lactamase - - - 0.000000001412 64.0
HKD2_k127_1179779_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 566.0
HKD2_k127_1179779_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 509.0
HKD2_k127_1179779_10 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000002799 136.0
HKD2_k127_1179779_11 KWG Leptospira - - - 0.000000000000000000001173 101.0
HKD2_k127_1179779_12 Methyltransferase type 11 K00574 - 2.1.1.79 0.000000000000001005 89.0
HKD2_k127_1179779_13 Methyltransferase domain - - - 0.0000000000007292 79.0
HKD2_k127_1179779_14 Tetratricopeptide repeat - - - 0.000000002332 68.0
HKD2_k127_1179779_15 Roadblock/LC7 domain - - - 0.0000002636 57.0
HKD2_k127_1179779_16 Pkd domain containing protein - - - 0.00001854 55.0
HKD2_k127_1179779_2 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 367.0
HKD2_k127_1179779_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 342.0
HKD2_k127_1179779_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 303.0
HKD2_k127_1179779_5 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001217 281.0
HKD2_k127_1179779_6 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002785 289.0
HKD2_k127_1179779_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000002087 240.0
HKD2_k127_1179779_8 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000002195 157.0
HKD2_k127_1179779_9 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000007155 147.0
HKD2_k127_1180387_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 451.0
HKD2_k127_1180387_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 300.0
HKD2_k127_1180387_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 299.0
HKD2_k127_1180387_3 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 301.0
HKD2_k127_1180387_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000001434 201.0
HKD2_k127_1180387_5 PFAM von Willebrand factor type A - - - 0.000000000000000003639 95.0
HKD2_k127_1180387_6 - - - - 0.0000000000000001204 82.0
HKD2_k127_1180387_7 Phage integrase family - - - 0.0000005486 57.0
HKD2_k127_1180387_8 von Willebrand factor, type A K07114 - - 0.00005607 55.0
HKD2_k127_1184811_0 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006136 246.0
HKD2_k127_1184811_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000004067 134.0
HKD2_k127_1184811_2 Zn-dependent protease with chaperone function - - - 0.000000000000001379 88.0
HKD2_k127_1184811_3 Bacterial regulatory proteins, tetR family - - - 0.000000001412 68.0
HKD2_k127_1184811_4 Anti-sigma-K factor rskA - - - 0.0000004506 60.0
HKD2_k127_1189400_0 Belongs to the peptidase M16 family K07263 - - 0.0 1034.0
HKD2_k127_1189400_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.788e-271 846.0
HKD2_k127_1189400_10 Tetratricopeptide repeat - - - 0.000000000000002321 87.0
HKD2_k127_1189400_11 Alpha/beta hydrolase family - - - 0.000000000000004443 86.0
HKD2_k127_1189400_12 Polysaccharide biosynthesis protein K15894 - 4.2.1.115 0.000001011 57.0
HKD2_k127_1189400_13 ABC-type phosphate phosphonate transport system periplasmic component - - - 0.00000142 60.0
HKD2_k127_1189400_14 Carboxypeptidase regulatory-like domain - - - 0.00003797 57.0
HKD2_k127_1189400_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 368.0
HKD2_k127_1189400_3 S-adenosyl-l-methionine hydroxide adenosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 335.0
HKD2_k127_1189400_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000001785 229.0
HKD2_k127_1189400_5 VIT family - - - 0.0000000000000000000000000000000000000000000000000002224 192.0
HKD2_k127_1189400_6 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000002974 203.0
HKD2_k127_1189400_7 - - - - 0.0000000000000000000000000000000000000000000000001127 189.0
HKD2_k127_1189400_8 - K12065 - - 0.0000000000000000000000000000000000000000000000001154 193.0
HKD2_k127_1189400_9 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000001742 139.0
HKD2_k127_1190465_0 AcrB/AcrD/AcrF family - - - 0.0 1237.0
HKD2_k127_1190465_1 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 2.249e-212 706.0
HKD2_k127_1190465_10 DNA-binding transcription factor activity - - - 0.00000000000000000000000007695 109.0
HKD2_k127_1190465_11 Protein of unknown function (DUF2892) - - - 0.000000000001108 69.0
HKD2_k127_1190465_2 PFAM Sugar (and other) transporter K08368,K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 512.0
HKD2_k127_1190465_3 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 305.0
HKD2_k127_1190465_4 Belongs to the arginase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 291.0
HKD2_k127_1190465_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000009591 222.0
HKD2_k127_1190465_6 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000000002788 196.0
HKD2_k127_1190465_7 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000098 194.0
HKD2_k127_1190465_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000001895 143.0
HKD2_k127_1190465_9 Stage II sporulation protein E K07315 - 3.1.3.3 0.00000000000000000000000000000005914 143.0
HKD2_k127_1198551_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008087 521.0
HKD2_k127_1198551_1 Bacterial regulatory protein, Fis family K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 305.0
HKD2_k127_1198551_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000004325 200.0
HKD2_k127_1198551_3 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000004961 128.0
HKD2_k127_1242476_0 PFAM FAD dependent oxidoreductase K15736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 409.0
HKD2_k127_1242476_1 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003666 274.0
HKD2_k127_1242476_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000002468 138.0
HKD2_k127_1242476_3 - - - - 0.00000000008842 69.0
HKD2_k127_124562_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.954e-207 664.0
HKD2_k127_124562_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000001295 223.0
HKD2_k127_124562_2 PFAM membrane-flanked domain - - - 0.00000000000000000000000000000000000001519 151.0
HKD2_k127_124562_3 ThiF family - - - 0.00000000000000000000000007203 120.0
HKD2_k127_124562_4 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000003781 108.0
HKD2_k127_124562_5 heme-binding sites - - - 0.00000000000000000000006701 112.0
HKD2_k127_124562_6 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000004438 102.0
HKD2_k127_124562_7 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03169 - 5.99.1.2 0.0000000000000000004803 89.0
HKD2_k127_124562_8 Protein of unknown function (DUF507) K09804 - - 0.00000000000000425 80.0
HKD2_k127_124562_9 Protein of unknown function (DUF507) K09804 - - 0.00000000003845 66.0
HKD2_k127_1286031_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 377.0
HKD2_k127_1286031_1 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 382.0
HKD2_k127_1295858_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1284.0
HKD2_k127_1295858_1 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 9.437e-301 933.0
HKD2_k127_1295858_10 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000005172 133.0
HKD2_k127_1295858_11 PFAM glycosyl transferase family 2 - - - 0.0000000000000000007233 100.0
HKD2_k127_1295858_12 - - - - 0.000000000001547 78.0
HKD2_k127_1295858_13 Polysaccharide biosynthesis C-terminal domain - - - 0.000000004539 69.0
HKD2_k127_1295858_14 - - - - 0.0000562 55.0
HKD2_k127_1295858_2 ATP-grasp domain K01905,K22224 - 6.2.1.13 1.384e-222 717.0
HKD2_k127_1295858_3 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 414.0
HKD2_k127_1295858_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001444 254.0
HKD2_k127_1295858_5 - - - - 0.0000000000000000000000000000000000000001689 171.0
HKD2_k127_1295858_6 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000001266 163.0
HKD2_k127_1295858_7 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000005705 156.0
HKD2_k127_1295858_8 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000002762 145.0
HKD2_k127_1295858_9 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000007831 142.0
HKD2_k127_1295859_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1785.0
HKD2_k127_1295859_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760 - 2.5.1.48,4.4.1.1,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 563.0
HKD2_k127_1295859_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 405.0
HKD2_k127_1295859_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000002933 153.0
HKD2_k127_1295859_4 Universal stress protein family - - - 0.0000000000000000000000000000252 122.0
HKD2_k127_1295859_5 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000009972 87.0
HKD2_k127_1295859_6 Transfers the fatty acyl group on membrane lipoproteins - - - 0.0000000000002313 81.0
HKD2_k127_1295859_7 - - - - 0.00000007921 57.0
HKD2_k127_1295859_8 long-chain fatty acid transporting porin activity - - - 0.0000005212 62.0
HKD2_k127_1298582_0 Metallo-beta-lactamase superfamily K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 485.0
HKD2_k127_1298582_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 391.0
HKD2_k127_1298582_2 RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000001959 185.0
HKD2_k127_1298582_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000001109 64.0
HKD2_k127_1304109_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 3.466e-297 917.0
HKD2_k127_1304109_1 Tetratricopeptide repeat K12132 - 2.7.11.1 1.733e-241 773.0
HKD2_k127_1304109_10 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000001658 164.0
HKD2_k127_1304109_11 Phosphoglycerate mutase - - - 0.00000000000000000000000000000000000008982 152.0
HKD2_k127_1304109_12 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000008265 105.0
HKD2_k127_1304109_13 Smr domain - - - 0.000000000000000000005338 98.0
HKD2_k127_1304109_14 - - - - 0.000000002104 68.0
HKD2_k127_1304109_15 - - - - 0.00003834 49.0
HKD2_k127_1304109_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 534.0
HKD2_k127_1304109_3 Alanine dehydrogenase/PNT, C-terminal domain K00324 GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0097159,GO:1901265,GO:1901363 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 469.0
HKD2_k127_1304109_4 PFAM Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006314 283.0
HKD2_k127_1304109_5 WG containing repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000917 229.0
HKD2_k127_1304109_6 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000001498 223.0
HKD2_k127_1304109_7 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000001742 217.0
HKD2_k127_1304109_8 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000009433 186.0
HKD2_k127_1304109_9 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000002644 178.0
HKD2_k127_1333882_0 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 548.0
HKD2_k127_1333882_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000643 237.0
HKD2_k127_1334774_0 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 3.037e-216 693.0
HKD2_k127_1334774_1 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 417.0
HKD2_k127_1334774_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002818 260.0
HKD2_k127_1334774_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000002013 147.0
HKD2_k127_1334774_4 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000342 116.0
HKD2_k127_1334774_6 PFAM Glycosyl transferase family 2 - - - 0.00000000009804 72.0
HKD2_k127_1338762_0 - K12065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 301.0
HKD2_k127_1338762_1 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000005508 190.0
HKD2_k127_1338762_2 - - - - 0.000000000000000000000000000000000000000003864 162.0
HKD2_k127_1338762_3 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000003504 134.0
HKD2_k127_1363938_0 ATP synthase alpha/beta family, beta-barrel domain K02412,K03224 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 532.0
HKD2_k127_1363938_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 407.0
HKD2_k127_1363938_10 PFAM VanZ like - - - 0.00000000000006224 78.0
HKD2_k127_1363938_11 YscO-like protein - - - 0.0000000000003004 76.0
HKD2_k127_1363938_12 Thioesterase superfamily - - - 0.0000000000009206 75.0
HKD2_k127_1363938_13 flagellar K02418 - - 0.000000001018 66.0
HKD2_k127_1363938_14 Role in flagellar biosynthesis K02420 - - 0.000000004353 59.0
HKD2_k127_1363938_15 Forkhead associated domain - - - 0.000000005757 68.0
HKD2_k127_1363938_17 Tetratricopeptide repeat - - - 0.0000001825 58.0
HKD2_k127_1363938_2 SpoIVB peptidase S55 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 329.0
HKD2_k127_1363938_3 FliP family K03226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005455 278.0
HKD2_k127_1363938_4 Peptidase family M23 K21471 GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.00000000000000000000000000000000000000000000000005051 192.0
HKD2_k127_1363938_5 sigma factor activity K02405 - - 0.00000000000000000000000000000000000000002616 163.0
HKD2_k127_1363938_6 Secretory protein of YscJ/FliF family K03222 - - 0.000000000000000000000000000000003942 139.0
HKD2_k127_1363938_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000001488 115.0
HKD2_k127_1363938_8 Type III K03223 - - 0.00000000000000000004755 98.0
HKD2_k127_1363938_9 - - - - 0.000000000000001405 83.0
HKD2_k127_1373055_0 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 362.0
HKD2_k127_1373055_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000002675 188.0
HKD2_k127_1373055_2 protein depalmitoleylation K19882 GO:0000902,GO:0000904,GO:0003002,GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006464,GO:0006505,GO:0006507,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0007275,GO:0007389,GO:0007399,GO:0007409,GO:0007411,GO:0007444,GO:0007447,GO:0007450,GO:0008045,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009605,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009952,GO:0009953,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0012505,GO:0016043,GO:0016298,GO:0016787,GO:0016788,GO:0019538,GO:0019637,GO:0021532,GO:0021915,GO:0022008,GO:0023051,GO:0023057,GO:0030030,GO:0030111,GO:0030154,GO:0030163,GO:0030178,GO:0030182,GO:0031175,GO:0031974,GO:0032501,GO:0032502,GO:0032989,GO:0032990,GO:0035220,GO:0035222,GO:0035295,GO:0035601,GO:0036211,GO:0040011,GO:0042157,GO:0042159,GO:0042221,GO:0042330,GO:0042578,GO:0043009,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044267,GO:0044421,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046486,GO:0046488,GO:0048070,GO:0048073,GO:0048076,GO:0048190,GO:0048468,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0052689,GO:0060429,GO:0060828,GO:0061564,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0090090,GO:0097485,GO:0098732,GO:0120036,GO:0120039,GO:1901135,GO:1901564,GO:1901565,GO:1901575,GO:1903509,GO:1990697,GO:1990699 3.1.1.98 0.0000000000000000000000000000000000000000000001892 183.0
HKD2_k127_1380517_0 Aminotransferase class-III K09251 - 2.6.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 552.0
HKD2_k127_1380517_1 Aminotransferase class-III K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 507.0
HKD2_k127_1380517_10 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000007707 212.0
HKD2_k127_1380517_11 Lipocalin-like domain K03098 - - 0.00000000000000000000000000000000000000000000000001203 189.0
HKD2_k127_1380517_12 Polysaccharide lyase family 4, domain II - - - 0.00000000000000000000000000000000000000000000000006221 188.0
HKD2_k127_1380517_13 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 0.00000000000000000000000000000000000003193 156.0
HKD2_k127_1380517_14 Uncharacterized ACR, COG1678 K07735 - - 0.000000000000000000000000000003859 127.0
HKD2_k127_1380517_15 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000009699 113.0
HKD2_k127_1380517_16 Uncharacterized protein conserved in bacteria (DUF2169) - - - 0.0000000000000000000000002446 121.0
HKD2_k127_1380517_17 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.0000000000000000000007072 108.0
HKD2_k127_1380517_18 cheY-homologous receiver domain - - - 0.0000000592 63.0
HKD2_k127_1380517_19 PFAM Cytochrome c, class I K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000006172 60.0
HKD2_k127_1380517_2 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 456.0
HKD2_k127_1380517_20 Chemotaxis signal transduction protein K13488 - - 0.0000009398 60.0
HKD2_k127_1380517_21 Two component signalling adaptor domain K03408 - - 0.0000133 54.0
HKD2_k127_1380517_3 COG0464 ATPases of the AAA class - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009976 439.0
HKD2_k127_1380517_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 323.0
HKD2_k127_1380517_5 Signal transducing histidine kinase, homodimeric domain K03407,K13490 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 313.0
HKD2_k127_1380517_6 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008328 281.0
HKD2_k127_1380517_7 PFAM chemotaxis sensory transducer - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006675 267.0
HKD2_k127_1380517_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000005833 232.0
HKD2_k127_1380517_9 Putative outer membrane beta-barrel porin, MtrB/PioB K22110 - - 0.000000000000000000000000000000000000000000000000000000000004189 234.0
HKD2_k127_1383230_0 4Fe-4S binding domain - - - 2.273e-260 824.0
HKD2_k127_1383230_1 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 530.0
HKD2_k127_1383230_2 Arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 346.0
HKD2_k127_1401364_0 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 443.0
HKD2_k127_1401364_1 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 325.0
HKD2_k127_1401364_2 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000943 253.0
HKD2_k127_1401364_3 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000008937 233.0
HKD2_k127_1401364_4 CoA-substrate-specific enzyme activase - - - 0.000000000000000000000000000000000000000000000000000000000001371 219.0
HKD2_k127_1401364_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002386 222.0
HKD2_k127_1401364_6 - - - - 0.000000000000000000000000000000001567 139.0
HKD2_k127_1401364_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000003124 136.0
HKD2_k127_1401364_8 DinB superfamily - - - 0.0000133 54.0
HKD2_k127_1442438_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 342.0
HKD2_k127_1442438_1 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000003745 231.0
HKD2_k127_1442438_2 RelA SpoT domain protein - - - 0.000000000000000000000000000000000000000000000000000000002861 228.0
HKD2_k127_1442438_3 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000002815 177.0
HKD2_k127_1442438_4 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.000000000000000000000000000000502 128.0
HKD2_k127_1442438_5 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.00000000000009785 76.0
HKD2_k127_1442438_6 Methyltransferase domain - - - 0.000000000001307 76.0
HKD2_k127_1442438_7 YceI-like domain - - - 0.000000001082 70.0
HKD2_k127_1470093_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 400.0
HKD2_k127_1470093_1 Receptor K02014 - - 0.0000008895 61.0
HKD2_k127_149943_0 TonB dependent receptor K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 325.0
HKD2_k127_149943_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000005927 248.0
HKD2_k127_149943_10 CARDB - - - 0.0000595 55.0
HKD2_k127_149943_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000008789 236.0
HKD2_k127_149943_3 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000412 220.0
HKD2_k127_149943_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000001455 221.0
HKD2_k127_149943_5 PFAM ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000004807 225.0
HKD2_k127_149943_6 response regulator - - - 0.000000000000000000000000000000000000000000000000000023 196.0
HKD2_k127_149943_7 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000001607 167.0
HKD2_k127_149943_8 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000004282 160.0
HKD2_k127_149943_9 TonB dependent receptor K16092 - - 0.00000000000000000000000000000000006062 153.0
HKD2_k127_1501104_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 576.0
HKD2_k127_1501104_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 404.0
HKD2_k127_1501104_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000237 260.0
HKD2_k127_1501104_3 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002519 249.0
HKD2_k127_1501104_4 - - - - 0.0000000000000000000000000000000000000000000000007781 179.0
HKD2_k127_1501104_5 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000005209 152.0
HKD2_k127_1501104_7 Biotin-requiring enzyme - - - 0.00000000000000001091 93.0
HKD2_k127_1501104_9 Protein of unknown function (DUF721) - - - 0.0004888 47.0
HKD2_k127_1511008_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 9.593e-251 783.0
HKD2_k127_1511008_1 glutamate-cysteine ligase activity K06048 GO:0003674,GO:0003824,GO:0016874,GO:0016879 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 501.0
HKD2_k127_1511008_10 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.0000000000000000000000000000000000001719 143.0
HKD2_k127_1511008_11 Membrane - - - 0.00000000000000000000000000000009007 139.0
HKD2_k127_1511008_12 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000002249 116.0
HKD2_k127_1511008_13 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000002895 119.0
HKD2_k127_1511008_14 von Willebrand factor, type A - - - 0.0000000000000000000006941 108.0
HKD2_k127_1511008_15 Redoxin K03564 - 1.11.1.15 0.0000000000000007169 78.0
HKD2_k127_1511008_16 cyclic nucleotide binding K01420,K10914 - - 0.0000000000006513 76.0
HKD2_k127_1511008_17 PBP superfamily domain K02040 GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234 - 0.00004143 54.0
HKD2_k127_1511008_2 NAD(P)-binding Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 494.0
HKD2_k127_1511008_3 Sodium/hydrogen exchanger family K03455,K11747 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 472.0
HKD2_k127_1511008_4 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 406.0
HKD2_k127_1511008_5 SAICAR synthetase K01923,K13713 - 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 393.0
HKD2_k127_1511008_6 Peptidase S8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 399.0
HKD2_k127_1511008_7 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 344.0
HKD2_k127_1511008_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000006056 196.0
HKD2_k127_1511008_9 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000006197 171.0
HKD2_k127_1528263_0 belongs to the aldehyde dehydrogenase family K00138 - - 5.668e-278 861.0
HKD2_k127_1528263_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 316.0
HKD2_k127_1528263_2 Protein of unknown function (DUF779) K09959 - - 0.00000000000000000000000000000000000000000000000000000004642 198.0
HKD2_k127_1528263_3 alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000572 209.0
HKD2_k127_1528263_4 - - - - 0.0000000000000000000000000000000000000000000000000001883 194.0
HKD2_k127_1528263_5 Transcriptional regulator PadR-like family - - - 0.0000000000000000185 90.0
HKD2_k127_1528263_6 gag-polyprotein putative aspartyl protease - - - 0.000000000004473 75.0
HKD2_k127_1528263_7 - - - - 0.00000001561 65.0
HKD2_k127_1541146_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 383.0
HKD2_k127_1541146_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K00558,K03572 GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 2.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 376.0
HKD2_k127_1541146_2 GTP binding K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002082 289.0
HKD2_k127_1541146_3 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000001624 168.0
HKD2_k127_1541146_4 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.00000001552 59.0
HKD2_k127_1541146_5 Histidine Phosphotransfer domain - - - 0.000006193 57.0
HKD2_k127_1544625_0 acyl-CoA dehydrogenase activity K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 522.0
HKD2_k127_1544625_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 433.0
HKD2_k127_1544625_2 transmembrane transporter activity K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 308.0
HKD2_k127_1544625_3 S-adenosylmethionine-dependent methyltransferase K00571,K06969,K12297 - 2.1.1.173,2.1.1.191,2.1.1.264,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 314.0
HKD2_k127_1544625_4 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001851 247.0
HKD2_k127_1544625_5 Enoyl-CoA hydratase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000007353 207.0
HKD2_k127_1544625_6 PFAM penicillin-binding protein transpeptidase K05364 - - 0.0000000000000000000000000000006787 139.0
HKD2_k127_1548149_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K07713 GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 390.0
HKD2_k127_1548149_1 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000008008 228.0
HKD2_k127_1548149_2 NUDIX domain - - - 0.000000000000000000000000000000000000000001893 162.0
HKD2_k127_1548149_3 - - - - 0.000000000000000000000000000000000000000007365 157.0
HKD2_k127_1548149_4 - - - - 0.000000000000000000000000000000003669 139.0
HKD2_k127_1548149_5 Response regulator receiver domain - - - 0.00000000000000000003218 94.0
HKD2_k127_1548149_7 HD domain - - - 0.000001773 55.0
HKD2_k127_1548149_8 von Willebrand factor (vWF) type A domain - - - 0.00005684 46.0
HKD2_k127_1548149_9 PFAM C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.00014 47.0
HKD2_k127_1563871_0 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 313.0
HKD2_k127_1563871_1 exonuclease activity K16899 - 3.6.4.12 0.00007938 55.0
HKD2_k127_1571651_0 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 404.0
HKD2_k127_1571651_1 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 357.0
HKD2_k127_1571651_2 SMART ATPase, AAA type, core K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 295.0
HKD2_k127_1571651_3 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001821 250.0
HKD2_k127_1571651_4 - - - - 0.0000000000000009401 87.0
HKD2_k127_1574141_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 1.173e-282 902.0
HKD2_k127_1574141_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 5.495e-196 649.0
HKD2_k127_1574141_10 YCII-related domain - - - 0.0000000000000000000000000000000000000000000002898 181.0
HKD2_k127_1574141_11 - - - - 0.000000000000000000000003443 109.0
HKD2_k127_1574141_12 Ankyrin repeat - - - 0.000000000000000000000003968 113.0
HKD2_k127_1574141_13 Serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.0002445 46.0
HKD2_k127_1574141_2 sigma factor activity K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 571.0
HKD2_k127_1574141_3 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K11102 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 434.0
HKD2_k127_1574141_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309,K11102 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 429.0
HKD2_k127_1574141_5 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003107 287.0
HKD2_k127_1574141_6 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003373 259.0
HKD2_k127_1574141_7 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002313 244.0
HKD2_k127_1574141_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000003933 213.0
HKD2_k127_1574141_9 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000305 192.0
HKD2_k127_1594419_0 PrkA AAA domain K07180 - - 0.0 1034.0
HKD2_k127_1594419_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000003282 244.0
HKD2_k127_1594419_2 Belongs to the UPF0229 family K09786 - - 0.000000005119 57.0
HKD2_k127_1594419_3 PFAM Tetratricopeptide - - - 0.00001869 55.0
HKD2_k127_1598276_0 xanthine dehydrogenase activity K07303 - 1.3.99.16 2.792e-247 781.0
HKD2_k127_1598276_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001717 271.0
HKD2_k127_1598276_2 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002999 241.0
HKD2_k127_1598276_3 aldo keto reductase - - - 0.000000000000000000000000234 106.0
HKD2_k127_1602527_0 FabA-like domain - - - 0.0 2396.0
HKD2_k127_1602527_1 PFAM Beta-ketoacyl synthase - - - 0.0 2034.0
HKD2_k127_1602527_10 Alkylmercury lyase - - - 0.000000343 53.0
HKD2_k127_1602527_2 PFAM AMP-dependent synthetase and ligase K22319 - 6.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 610.0
HKD2_k127_1602527_3 TIGRFAM PfaD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 547.0
HKD2_k127_1602527_4 PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III K22317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 484.0
HKD2_k127_1602527_5 Serine aminopeptidase, S33 K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 397.0
HKD2_k127_1602527_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 391.0
HKD2_k127_1602527_7 3-Beta hydroxysteroid dehydrogenase isomerase K21271,K22320 - 1.1.1.394,1.1.1.412 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 332.0
HKD2_k127_1602527_8 TIGRFAM PfaD family protein - - - 0.0000000000000000000003083 100.0
HKD2_k127_1602527_9 Alkylmercury lyase - - - 0.000000000000000007649 89.0
HKD2_k127_1611760_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 606.0
HKD2_k127_1611760_1 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 511.0
HKD2_k127_1611760_10 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000004161 104.0
HKD2_k127_1611760_11 - - - - 0.00000007109 57.0
HKD2_k127_1611760_2 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 493.0
HKD2_k127_1611760_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 472.0
HKD2_k127_1611760_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 468.0
HKD2_k127_1611760_5 PFAM Acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 436.0
HKD2_k127_1611760_6 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000005646 209.0
HKD2_k127_1611760_7 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000001343 198.0
HKD2_k127_1611760_8 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000001527 170.0
HKD2_k127_1611760_9 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000001976 144.0
HKD2_k127_1615628_0 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01739,K01758,K01760,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 510.0
HKD2_k127_1615628_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 410.0
HKD2_k127_1615628_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 385.0
HKD2_k127_1615628_3 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000000000000000000008704 180.0
HKD2_k127_1615628_4 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000000000000001283 179.0
HKD2_k127_1615628_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000005428 170.0
HKD2_k127_1615628_6 Radical SAM superfamily - - - 0.0000000000000000000003744 102.0
HKD2_k127_1623085_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 526.0
HKD2_k127_1623085_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000005513 232.0
HKD2_k127_1623085_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000002795 243.0
HKD2_k127_1623085_3 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000000000000000000000003923 237.0
HKD2_k127_1623085_4 - - - - 0.000000000000000000000000000000000000000003812 163.0
HKD2_k127_1681299_0 aminopeptidase activity K01301 - 3.4.17.21 2.534e-270 846.0
HKD2_k127_1681299_1 PFAM Amidohydrolase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 372.0
HKD2_k127_1682855_0 tail specific protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 376.0
HKD2_k127_1682855_1 Beta-lactamase class C - - - 0.000000000000000000000000000000000000000000000000000000003195 214.0
HKD2_k127_1682855_2 Bacterial regulatory proteins, tetR family - - - 0.00000000000000001538 91.0
HKD2_k127_1703334_0 - - - - 0.0000000000000000000000000000000000000000000001687 177.0
HKD2_k127_1704999_0 Associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 379.0
HKD2_k127_1704999_1 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000000000000000000000000000000000000000000001336 185.0
HKD2_k127_1704999_2 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - 0.000000002067 70.0
HKD2_k127_1704999_3 ABC transporter K01990 - - 0.00007549 48.0
HKD2_k127_1707740_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1093.0
HKD2_k127_1707740_1 Beta-lactamase K01256,K17836 - 3.4.11.2,3.5.2.6 0.000000000000000000000000000000000000000000000000000000379 204.0
HKD2_k127_1707740_2 DinB family - - - 0.000000000000000000000000000000000000001091 153.0
HKD2_k127_1708659_0 Malic enzyme, NAD binding domain K00027,K00029 - 1.1.1.38,1.1.1.40 2.34e-316 984.0
HKD2_k127_1708659_1 Stage II sporulation protein E (SpoIIE) - - - 5.038e-205 672.0
HKD2_k127_1708659_2 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007007 457.0
HKD2_k127_1708659_3 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K00156,K01652 - 1.2.5.1,2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 405.0
HKD2_k127_1708659_5 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000007026 68.0
HKD2_k127_1708659_7 Parallel beta-helix repeats - - - 0.0003514 53.0
HKD2_k127_1708659_8 ABC transporter (Permease) K02033,K02034 - - 0.0008835 45.0
HKD2_k127_1711891_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001666 303.0
HKD2_k127_1711891_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000008243 139.0
HKD2_k127_1711891_2 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF K07402 - - 0.00000000000000000000447 97.0
HKD2_k127_1735401_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1852.0
HKD2_k127_1735401_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0 1347.0
HKD2_k127_1735401_10 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000002067 208.0
HKD2_k127_1735401_11 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000102 91.0
HKD2_k127_1735401_2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.0 1042.0
HKD2_k127_1735401_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 1.514e-212 668.0
HKD2_k127_1735401_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007316 444.0
HKD2_k127_1735401_5 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 366.0
HKD2_k127_1735401_6 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 301.0
HKD2_k127_1735401_7 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000207 241.0
HKD2_k127_1735401_8 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00574,K07755 - 2.1.1.137,2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000835 231.0
HKD2_k127_1735401_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000000000000006562 227.0
HKD2_k127_1735504_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K17050 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 0.0 1611.0
HKD2_k127_1735504_1 Esterase PHB depolymerase K03932 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002909 284.0
HKD2_k127_1735504_2 Cytochrome c - - - 0.000000000000000000000000000000000000001085 160.0
HKD2_k127_1735504_3 Transcriptional regulator - - - 0.00000000000000009043 86.0
HKD2_k127_1735504_4 PFAM Bacterial regulatory protein, Fis family - - - 0.000001072 59.0
HKD2_k127_1735504_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0006451 50.0
HKD2_k127_176486_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008561 555.0
HKD2_k127_176486_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 527.0
HKD2_k127_176486_2 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 425.0
HKD2_k127_176486_3 Transposase IS200 like K07445 - - 0.000000000000000000000000000000000000000000003303 171.0
HKD2_k127_176486_4 Transposase IS116/IS110/IS902 family - - - 0.0000000000000000000000000000004955 135.0
HKD2_k127_176486_5 Putative esterase - - - 0.00000000000000000000000000002954 119.0
HKD2_k127_176486_6 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.0000005469 62.0
HKD2_k127_1785605_0 Cytochrome C assembly protein - - - 3.805e-237 755.0
HKD2_k127_1785605_1 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 449.0
HKD2_k127_1785605_10 transcriptional regulator - - - 0.0000000000000000000000000000000000000003665 156.0
HKD2_k127_1785605_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 435.0
HKD2_k127_1785605_3 ABC-2 type transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 439.0
HKD2_k127_1785605_4 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 405.0
HKD2_k127_1785605_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 337.0
HKD2_k127_1785605_6 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006302 329.0
HKD2_k127_1785605_7 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000007875 248.0
HKD2_k127_1785605_8 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000245 168.0
HKD2_k127_1785605_9 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000003987 159.0
HKD2_k127_1790779_0 Bacterial extracellular solute-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 505.0
HKD2_k127_1790779_1 Binding-protein-dependent transport system inner membrane component K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 351.0
HKD2_k127_1790779_2 Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 343.0
HKD2_k127_1790779_3 TIGRFAM sulfate ABC transporter, inner membrane subunit CysW K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009175 245.0
HKD2_k127_1790779_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000001798 209.0
HKD2_k127_1792478_0 PFAM ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 512.0
HKD2_k127_1792478_1 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 342.0
HKD2_k127_1792478_2 response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002352 297.0
HKD2_k127_1792478_3 Response regulator, receiver K01733,K22010 - 4.2.3.1 0.0000000000000000000000000000003534 126.0
HKD2_k127_1792478_4 Y_Y_Y domain - - - 0.00000000000000000004352 98.0
HKD2_k127_1792478_5 Preprotein translocase SecG subunit K03075 - - 0.000000000000003714 80.0
HKD2_k127_1792478_6 - - - - 0.00000000001153 73.0
HKD2_k127_1792478_7 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000005814 59.0
HKD2_k127_1792478_8 - - - - 0.00003689 53.0
HKD2_k127_1807515_0 Associated with various cellular activities K03924 - - 7.006e-272 843.0
HKD2_k127_1807515_1 PFAM peptidase M13 K07386 - - 6.872e-254 801.0
HKD2_k127_1807515_10 protein involved in tolerance to K03926 - - 0.00000000000000000000002538 106.0
HKD2_k127_1807515_11 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000002833 106.0
HKD2_k127_1807515_12 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000001426 99.0
HKD2_k127_1807515_13 spore germination - - - 0.0000000000005145 79.0
HKD2_k127_1807515_14 - - - - 0.000002069 58.0
HKD2_k127_1807515_15 Glycosyltransferase like family 2 - - - 0.000006405 56.0
HKD2_k127_1807515_2 oxidoreductase activity - - - 1.649e-236 745.0
HKD2_k127_1807515_3 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 512.0
HKD2_k127_1807515_4 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009466 464.0
HKD2_k127_1807515_5 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009779 281.0
HKD2_k127_1807515_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002307 238.0
HKD2_k127_1807515_7 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000008004 243.0
HKD2_k127_1807515_8 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000004576 244.0
HKD2_k127_1807515_9 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000006191 229.0
HKD2_k127_1851710_0 proteolysis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 297.0
HKD2_k127_1851710_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000001434 181.0
HKD2_k127_1851710_2 Protein kinase domain K12132 - 2.7.11.1 0.000006704 49.0
HKD2_k127_1874591_0 transcription factor binding K15836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000949 424.0
HKD2_k127_1875746_0 transporter, DctM subunit K11690 - - 1.12e-226 718.0
HKD2_k127_1875746_1 helix_turn_helix gluconate operon transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 535.0
HKD2_k127_1875746_10 PAP2 superfamily - - - 0.0000000001969 72.0
HKD2_k127_1875746_2 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 511.0
HKD2_k127_1875746_3 TRAP transporter T-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 383.0
HKD2_k127_1875746_4 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 371.0
HKD2_k127_1875746_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001645 279.0
HKD2_k127_1875746_6 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000005458 216.0
HKD2_k127_1875746_7 palmitoyl-(protein) hydrolase activity K06999 - - 0.0000000000000000000000000000000000000000000000000000000004067 221.0
HKD2_k127_1875746_8 Periplasmic or secreted lipoprotein - - - 0.000000000000001175 77.0
HKD2_k127_1875746_9 Papain family cysteine protease - - - 0.00000000004619 74.0
HKD2_k127_1900312_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 342.0
HKD2_k127_1900312_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 321.0
HKD2_k127_1900312_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000001163 214.0
HKD2_k127_1900312_3 anaphase-promoting complex binding K03497 - - 0.000000000000000000000000000000000000007764 165.0
HKD2_k127_1900312_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000008399 119.0
HKD2_k127_1900312_5 - - - - 0.0000008003 57.0
HKD2_k127_1932744_0 Fumarase C C-terminus - - - 6.289e-237 743.0
HKD2_k127_1932744_1 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 443.0
HKD2_k127_1932744_2 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D K01424,K05597 GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.1,3.5.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 433.0
HKD2_k127_1932744_3 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 382.0
HKD2_k127_1932744_4 Protein of unknown function (DUF2490) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002633 278.0
HKD2_k127_1932744_5 Anaerobic c4-dicarboxylate membrane transporter K07791,K07792 - - 0.0000000000000000000000000000000001436 136.0
HKD2_k127_1932744_6 - - - - 0.00000000000000000000000002015 115.0
HKD2_k127_193836_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 446.0
HKD2_k127_193836_1 (Rhomboid) family - - - 0.0000000000000000000000000000000000000000000000000005948 207.0
HKD2_k127_193836_2 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000007163 163.0
HKD2_k127_193836_3 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.00000000000000000000000000000000007381 146.0
HKD2_k127_193836_4 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000002155 121.0
HKD2_k127_193836_5 Rhodanese Homology Domain - - - 0.000000000000000007315 93.0
HKD2_k127_193836_6 Putative peptidoglycan binding domain - - - 0.00003897 57.0
HKD2_k127_1944389_0 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 505.0
HKD2_k127_1944389_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 336.0
HKD2_k127_1944389_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 325.0
HKD2_k127_1944389_3 Molybdate ABC transporter K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002705 269.0
HKD2_k127_1944389_4 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000008913 210.0
HKD2_k127_1944389_5 Tetratricopeptide repeat - - - 0.0000000000000000976 88.0
HKD2_k127_1962010_0 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 600.0
HKD2_k127_1962010_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 561.0
HKD2_k127_1962010_10 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000002616 233.0
HKD2_k127_1962010_11 PFAM Roadblock LC7 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000001556 218.0
HKD2_k127_1962010_12 NUDIX domain K03575 - - 0.0000000000000000000000000000000000000000000000000000000001156 218.0
HKD2_k127_1962010_13 Protein of unknown function (DUF2723) - - - 0.000000000000000000000000000000000000000000000000000002558 215.0
HKD2_k127_1962010_14 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000007063 199.0
HKD2_k127_1962010_15 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000000000003186 184.0
HKD2_k127_1962010_16 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000001967 177.0
HKD2_k127_1962010_17 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000259 167.0
HKD2_k127_1962010_18 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000005345 162.0
HKD2_k127_1962010_19 Thiol-disulfide oxidoreductase - - - 0.000000000000000000000000000000000000000002669 160.0
HKD2_k127_1962010_2 Belongs to the aldehyde dehydrogenase family K00128,K00129 - 1.2.1.3,1.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 543.0
HKD2_k127_1962010_20 PFAM molybdopterin binding domain - - - 0.000000000000000000000000000000000001081 143.0
HKD2_k127_1962010_21 YjbR - - - 0.000000000000000000000000000000001893 134.0
HKD2_k127_1962010_22 hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000007169 134.0
HKD2_k127_1962010_23 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.0000000000000000000000000000006127 127.0
HKD2_k127_1962010_24 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000007691 133.0
HKD2_k127_1962010_25 cell septum assembly - - - 0.00000000000000000000000003574 124.0
HKD2_k127_1962010_26 Chemotaxis protein CheY - - - 0.00000000000000000000000005787 111.0
HKD2_k127_1962010_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.000000000000000000000004041 105.0
HKD2_k127_1962010_28 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000002129 100.0
HKD2_k127_1962010_29 Transcriptional regulator, BadM Rrf2 family K13643 - - 0.00000000000000000007148 96.0
HKD2_k127_1962010_3 Peptidase dimerisation domain K13049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 490.0
HKD2_k127_1962010_30 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000549 102.0
HKD2_k127_1962010_31 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000002975 92.0
HKD2_k127_1962010_33 PFAM glycosyl transferase, family 28 K05841 - 2.4.1.173 0.0000000000000005444 90.0
HKD2_k127_1962010_34 Belongs to the universal stress protein A family - - - 0.00000000000003435 83.0
HKD2_k127_1962010_35 Encoded by K01518 GO:0003674,GO:0003824,GO:0004081,GO:0004551,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006172,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0008150,GO:0008152,GO:0008219,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012501,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043135,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046033,GO:0046034,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.6.1.17 0.00000000006224 73.0
HKD2_k127_1962010_36 Cytochrome c - - - 0.0000000006915 65.0
HKD2_k127_1962010_38 Belongs to the universal stress protein A family - - - 0.0008318 51.0
HKD2_k127_1962010_4 PFAM peptidase M48 Ste24p K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 474.0
HKD2_k127_1962010_5 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 457.0
HKD2_k127_1962010_6 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 342.0
HKD2_k127_1962010_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 332.0
HKD2_k127_1962010_8 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 302.0
HKD2_k127_1962010_9 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000000000000000000000000002299 266.0
HKD2_k127_1971195_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 621.0
HKD2_k127_1971195_1 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001227 298.0
HKD2_k127_1971195_2 Aminotransferase class I and II K00814 - 2.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001929 266.0
HKD2_k127_1971195_3 PFAM Class II aldolase adducin K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000101 242.0
HKD2_k127_1971195_4 acyl-coa hydrolase K01073 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.2.20 0.00000000000000000000000000000000000000000000001727 175.0
HKD2_k127_1971195_5 COG2199 FOG GGDEF domain K18968 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.00000000000000000000000000000000000000004003 165.0
HKD2_k127_1971195_6 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000005964 128.0
HKD2_k127_1971195_7 PFAM aminotransferase, class I and II K00814 - 2.6.1.2 0.00000000000000000000000002539 121.0
HKD2_k127_1971195_8 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000001673 125.0
HKD2_k127_1971195_9 SMART Tetratricopeptide - - - 0.0000000000000000000001321 105.0
HKD2_k127_1972256_0 PFAM Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 334.0
HKD2_k127_1972256_1 - - - - 0.000000000000000000000000000000000000000000000000000001531 200.0
HKD2_k127_1972256_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000001282 186.0
HKD2_k127_1972256_3 ABC transporter K01990 - - 0.000000000000000000000000000000000000001466 158.0
HKD2_k127_1972256_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000001337 102.0
HKD2_k127_1972256_5 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.000002919 57.0
HKD2_k127_1981301_0 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 445.0
HKD2_k127_1981301_1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 342.0
HKD2_k127_1981301_2 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 329.0
HKD2_k127_1981301_3 Outer membrane efflux protein K15725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 314.0
HKD2_k127_1981301_4 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000001953 233.0
HKD2_k127_1981301_5 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000006524 184.0
HKD2_k127_1981301_6 - - - - 0.000000000000000002814 85.0
HKD2_k127_2040197_0 Wzt C-terminal domain K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 318.0
HKD2_k127_2040197_1 Belongs to the peptidase S26 family - - - 0.000000000000000000000000000000000000002912 154.0
HKD2_k127_2040197_2 PFAM Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000001402 119.0
HKD2_k127_2105396_0 Belongs to the DEAD box helicase family K05592,K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009977 463.0
HKD2_k127_2105396_1 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 311.0
HKD2_k127_2105396_2 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000909 241.0
HKD2_k127_2105396_3 Ser Thr phosphatase family protein K07098 - - 0.00000000000000000000000000000000000000000000000000000000189 215.0
HKD2_k127_2105396_4 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000001817 196.0
HKD2_k127_2105396_5 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000009948 82.0
HKD2_k127_2105396_6 FHA domain K07315 - 3.1.3.3 0.0000000007789 70.0
HKD2_k127_2105396_7 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000002794 56.0
HKD2_k127_210729_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.168e-259 823.0
HKD2_k127_210729_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.647e-219 687.0
HKD2_k127_210729_10 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000198 145.0
HKD2_k127_210729_11 - K00003,K00058,K01754,K04517,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19 0.0000000000000000000000000000004484 131.0
HKD2_k127_210729_12 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000005383 114.0
HKD2_k127_210729_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008481 548.0
HKD2_k127_210729_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 451.0
HKD2_k127_210729_4 tetratricopeptide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 398.0
HKD2_k127_210729_5 adenylosuccinate lyase K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 402.0
HKD2_k127_210729_6 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 283.0
HKD2_k127_210729_7 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001636 273.0
HKD2_k127_210729_8 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002737 278.0
HKD2_k127_210729_9 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000009417 249.0
HKD2_k127_2132872_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009728 514.0
HKD2_k127_2132872_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 537.0
HKD2_k127_2132872_10 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 316.0
HKD2_k127_2132872_11 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004808 284.0
HKD2_k127_2132872_12 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002339 294.0
HKD2_k127_2132872_13 RDD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003473 286.0
HKD2_k127_2132872_14 including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005848 272.0
HKD2_k127_2132872_15 histone acetyltransferase binding - - - 0.000000000000000000000000000000000000000000000000000000000000004617 233.0
HKD2_k127_2132872_16 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000008707 229.0
HKD2_k127_2132872_17 Belongs to the BshC family K22136 - - 0.0000000000000000000000000000000000000000000000000000000000001982 231.0
HKD2_k127_2132872_18 RDD family - - - 0.000000000000000000000000000000000000000000000000000000000006897 215.0
HKD2_k127_2132872_19 Raf kinase inhibitor-like protein, YbhB YbcL family K06910 - - 0.000000000000000000000000000000000000000000000000000002455 196.0
HKD2_k127_2132872_2 Mismatch repair ATPase (MutS family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 517.0
HKD2_k127_2132872_20 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000008013 195.0
HKD2_k127_2132872_21 Protein of unknown function (DUF2400) - - - 0.000000000000000000000000000000000000000000000000002268 195.0
HKD2_k127_2132872_22 - - - - 0.000000000000000000000000000000000000000001175 162.0
HKD2_k127_2132872_23 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000004367 138.0
HKD2_k127_2132872_24 peptidase - - - 0.0000000000000000000000000000002125 132.0
HKD2_k127_2132872_25 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000003324 127.0
HKD2_k127_2132872_26 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000003846 121.0
HKD2_k127_2132872_27 - - - - 0.000000000000000000000532 101.0
HKD2_k127_2132872_28 peptidyl-tyrosine sulfation - - - 0.00000000000000000000137 105.0
HKD2_k127_2132872_29 - - - - 0.00000000000004284 84.0
HKD2_k127_2132872_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 446.0
HKD2_k127_2132872_4 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 440.0
HKD2_k127_2132872_5 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 432.0
HKD2_k127_2132872_6 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007727 391.0
HKD2_k127_2132872_7 Domain of unknown function (DUF4129) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 398.0
HKD2_k127_2132872_8 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 368.0
HKD2_k127_2132872_9 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 312.0
HKD2_k127_2157211_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 404.0
HKD2_k127_2157211_1 domain protein K13735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001675 288.0
HKD2_k127_2157211_2 metallopeptidase activity - - - 0.0000000000002866 83.0
HKD2_k127_2157211_3 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0002677 44.0
HKD2_k127_2164006_0 MutS domain I K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 619.0
HKD2_k127_2164006_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000001784 160.0
HKD2_k127_2183507_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 543.0
HKD2_k127_2183507_1 - - - - 0.00000000000000000000000000000000000007659 145.0
HKD2_k127_2183507_2 GYD domain - - - 0.00000000000000000000000000000000002338 137.0
HKD2_k127_2191847_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000143 251.0
HKD2_k127_2191847_1 Cna B domain protein - - - 0.00000000000000000002494 107.0
HKD2_k127_2191847_2 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.000000000000005006 78.0
HKD2_k127_2230724_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 3.798e-233 747.0
HKD2_k127_2230724_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 614.0
HKD2_k127_2230724_2 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001465 261.0
HKD2_k127_2230724_3 Pyridine nucleotide-disulphide oxidoreductase K00384,K21567 - 1.18.1.2,1.19.1.1,1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000001477 249.0
HKD2_k127_2230724_4 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000003043 192.0
HKD2_k127_2230724_5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141,K19190 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760 1.1.1.328,2.7.7.76 0.000000000000000000000000000007062 126.0
HKD2_k127_2264165_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 371.0
HKD2_k127_2264165_1 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 320.0
HKD2_k127_2264165_10 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.000000000000001306 84.0
HKD2_k127_2264165_11 - - - - 0.00000000000002 76.0
HKD2_k127_2264165_12 - - - - 0.0000000000009653 72.0
HKD2_k127_2264165_2 Electron transfer flavoprotein alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 317.0
HKD2_k127_2264165_3 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 296.0
HKD2_k127_2264165_4 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000007568 260.0
HKD2_k127_2264165_5 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000219 244.0
HKD2_k127_2264165_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000002526 248.0
HKD2_k127_2264165_7 Ku70/Ku80 beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000007885 223.0
HKD2_k127_2264165_8 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000009488 220.0
HKD2_k127_2264165_9 antisigma factor binding K04749,K06378 - - 0.000000000000000000000000006367 114.0
HKD2_k127_226873_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.174e-284 887.0
HKD2_k127_226873_1 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 393.0
HKD2_k127_226873_2 PFAM band 7 protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 376.0
HKD2_k127_226873_3 NfeD-like C-terminal, partner-binding - - - 0.0000000000000000000000007456 112.0
HKD2_k127_226873_4 ankyrin repeat K15502 - - 0.00000000000000000000001424 110.0
HKD2_k127_2271346_0 Hydrogenase formation hypA family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 484.0
HKD2_k127_2271346_1 PFAM AIR synthase related protein, N-terminal domain K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 337.0
HKD2_k127_2271346_2 diguanylate cyclase - - - 0.00000000000000000000000005446 126.0
HKD2_k127_2271346_3 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.00000000000000000001344 94.0
HKD2_k127_2271346_4 - K07403 - - 0.0005064 46.0
HKD2_k127_227737_0 Domain of unknown function (DUF362) - - - 8.235e-228 710.0
HKD2_k127_227737_1 N-Acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 480.0
HKD2_k127_227737_10 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000002046 220.0
HKD2_k127_227737_11 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000009154 162.0
HKD2_k127_227737_12 - - - - 0.000000000000000000000000000000000000000004938 159.0
HKD2_k127_227737_13 Glycine cleavage system K03567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000005338 139.0
HKD2_k127_227737_14 - - - - 0.0000000000000000000000000000001708 135.0
HKD2_k127_227737_15 RNA recognition motif - - - 0.00000000000000000000000001165 114.0
HKD2_k127_227737_16 alpha-ribazole phosphatase activity K01834 - 5.4.2.11 0.000000000000000000000004016 108.0
HKD2_k127_227737_18 Amidinotransferase - - - 0.000000000000000002762 98.0
HKD2_k127_227737_19 Universal stress protein family - - - 0.00000000000002018 83.0
HKD2_k127_227737_2 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 431.0
HKD2_k127_227737_3 Abc transporter K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 358.0
HKD2_k127_227737_4 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 326.0
HKD2_k127_227737_5 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 327.0
HKD2_k127_227737_6 Pregnancy-associated plasma protein-A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004772 273.0
HKD2_k127_227737_7 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001669 259.0
HKD2_k127_227737_8 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000001086 226.0
HKD2_k127_227737_9 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000002925 214.0
HKD2_k127_2284346_0 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 463.0
HKD2_k127_2284346_1 Sulfate permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006718 415.0
HKD2_k127_2284346_2 regulation of ruffle assembly - - - 0.00000000000000000000000003375 114.0
HKD2_k127_2350975_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 632.0
HKD2_k127_2350975_1 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 545.0
HKD2_k127_2350975_10 - - - - 0.000007748 59.0
HKD2_k127_2350975_2 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 518.0
HKD2_k127_2350975_3 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 477.0
HKD2_k127_2350975_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 341.0
HKD2_k127_2350975_5 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 340.0
HKD2_k127_2350975_6 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000004165 220.0
HKD2_k127_2350975_7 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000001009 231.0
HKD2_k127_2350975_8 Two component regulator propeller - - - 0.000000000000000000000000001493 125.0
HKD2_k127_2350975_9 domain protein - - - 0.000000000000001419 89.0
HKD2_k127_2425245_0 Sortilin, neurotensin receptor 3, - - - 0.0 1168.0
HKD2_k127_2425245_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 1.459e-218 687.0
HKD2_k127_2425245_10 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000003654 198.0
HKD2_k127_2425245_11 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.00000000000000000000000000000000000000000000003186 176.0
HKD2_k127_2425245_12 YhhN family - - - 0.00000000000000000000000000000000000000000003211 169.0
HKD2_k127_2425245_13 AdoMet dependent proline di-methyltransferase - - - 0.00000000000000000000000000000000000007021 155.0
HKD2_k127_2425245_14 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000001507 150.0
HKD2_k127_2425245_15 CYTH K05873 - 4.6.1.1 0.00000000000000000000000000000000004161 143.0
HKD2_k127_2425245_16 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000004172 83.0
HKD2_k127_2425245_17 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000004045 55.0
HKD2_k127_2425245_2 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 621.0
HKD2_k127_2425245_3 succinyl-diaminopimelate desuccinylase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009518 578.0
HKD2_k127_2425245_4 Aldehyde dehydrogenase family K22187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 502.0
HKD2_k127_2425245_5 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 411.0
HKD2_k127_2425245_6 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009074 387.0
HKD2_k127_2425245_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 355.0
HKD2_k127_2425245_8 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 296.0
HKD2_k127_2425245_9 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000003166 209.0
HKD2_k127_2428639_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003435 501.0
HKD2_k127_2428639_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K03797 - 3.1.11.6,3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 366.0
HKD2_k127_2428639_10 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000002346 147.0
HKD2_k127_2428639_11 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000000175 128.0
HKD2_k127_2428639_12 Protein of unknown function (DUF3303) - - - 0.00000000000000000000000000000003388 128.0
HKD2_k127_2428639_13 FR47-like protein - - - 0.000000000000000000000006211 108.0
HKD2_k127_2428639_14 transferase activity, transferring glycosyl groups - - - 0.0000000000000000005684 100.0
HKD2_k127_2428639_16 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000001011 79.0
HKD2_k127_2428639_17 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000002536 76.0
HKD2_k127_2428639_18 transferase activity, transferring glycosyl groups K00786 - - 0.00002914 55.0
HKD2_k127_2428639_2 PFAM Metallophosphoesterase K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 316.0
HKD2_k127_2428639_3 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009957 284.0
HKD2_k127_2428639_4 TIGRFAM hemolysin TlyA family protein K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000006749 250.0
HKD2_k127_2428639_5 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000002399 239.0
HKD2_k127_2428639_6 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000004617 187.0
HKD2_k127_2428639_7 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000002407 190.0
HKD2_k127_2428639_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000345 172.0
HKD2_k127_2428639_9 His Kinase A (phosphoacceptor - - - 0.000000000000000000000000000000000000000000005716 170.0
HKD2_k127_2432658_0 Chromate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 513.0
HKD2_k127_2432658_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 494.0
HKD2_k127_2432658_10 MreB/Mbl protein K03569 - - 0.00000000000000000000000000000000000000000000000003964 191.0
HKD2_k127_2432658_11 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000003318 173.0
HKD2_k127_2432658_12 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000001643 76.0
HKD2_k127_2432658_13 Lipid A 3-O-deacylase (PagL) - - - 0.00000002055 63.0
HKD2_k127_2432658_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 390.0
HKD2_k127_2432658_3 PFAM histone deacetylase superfamily K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 383.0
HKD2_k127_2432658_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 390.0
HKD2_k127_2432658_5 Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily K00001,K00344 - 1.1.1.1,1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 348.0
HKD2_k127_2432658_6 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 310.0
HKD2_k127_2432658_7 methionine synthase K00544,K00548 - 2.1.1.13,2.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000003442 266.0
HKD2_k127_2432658_8 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000005652 236.0
HKD2_k127_2432658_9 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000000000000001784 188.0
HKD2_k127_249009_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 522.0
HKD2_k127_249009_1 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002771 248.0
HKD2_k127_249009_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000001388 237.0
HKD2_k127_249009_3 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000002769 93.0
HKD2_k127_2495753_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 502.0
HKD2_k127_2495753_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000003602 136.0
HKD2_k127_2522122_0 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 488.0
HKD2_k127_2522122_1 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 306.0
HKD2_k127_2522122_10 Pectate lyase K01728 - 4.2.2.2 0.000000004896 70.0
HKD2_k127_2522122_11 cAMP biosynthetic process K03641 - - 0.000007611 51.0
HKD2_k127_2522122_2 Alpha beta hydrolase fold protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001244 273.0
HKD2_k127_2522122_3 COG3119 Arylsulfatase A and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002481 271.0
HKD2_k127_2522122_4 Glycosyltransferase family 10 (fucosyltransferase) C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001694 251.0
HKD2_k127_2522122_5 Pfam Cupin - - - 0.000000000000000000000000000000000000000000000001339 178.0
HKD2_k127_2522122_6 Cadherin repeats. - - - 0.000000000000000000000000000000000000000000008555 188.0
HKD2_k127_2522122_7 DNA-binding transcription factor activity - - - 0.0000000000000000000000000008142 118.0
HKD2_k127_2522122_8 Transglycosylase associated protein - - - 0.000000000000006194 77.0
HKD2_k127_2522122_9 - - - - 0.00000000000002991 76.0
HKD2_k127_2540450_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 5.446e-317 981.0
HKD2_k127_2540450_1 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 500.0
HKD2_k127_2540450_2 glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000005577 171.0
HKD2_k127_2540450_3 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000005685 154.0
HKD2_k127_2540450_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000004527 156.0
HKD2_k127_2540450_5 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000003582 134.0
HKD2_k127_2540450_7 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.0000006672 60.0
HKD2_k127_2540450_8 Belongs to the N-Me-Phe pilin family - - - 0.00002309 55.0
HKD2_k127_2555356_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 371.0
HKD2_k127_2555356_1 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000003775 246.0
HKD2_k127_2555356_2 Amino acid permease - - - 0.0000000000000000000000000000000000000000000002967 179.0
HKD2_k127_2555356_3 Transposase K07491 - - 0.000000000000000000000000000000000000001832 154.0
HKD2_k127_2555356_4 COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain) - - - 0.0000000000000000000000000000000878 134.0
HKD2_k127_2570928_0 Belongs to the ClpA ClpB family K03696 - - 2.743e-315 985.0
HKD2_k127_2570928_1 cystathionine gamma-synthase activity K01739,K01758,K01760,K01761 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008791 477.0
HKD2_k127_2570928_2 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 458.0
HKD2_k127_2570928_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 454.0
HKD2_k127_2570928_4 Surface antigen variable number K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 375.0
HKD2_k127_2570928_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001201 252.0
HKD2_k127_2570928_6 Biotin/lipoate A/B protein ligase family K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.0000000000000000000000000000000000000001249 160.0
HKD2_k127_2570928_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000003423 112.0
HKD2_k127_2570928_8 PFAM Septum formation initiator K05589 - - 0.00000008941 58.0
HKD2_k127_2575181_0 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 323.0
HKD2_k127_2575181_1 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000004417 196.0
HKD2_k127_2575181_2 Transcription factor zinc-finger K09981 - - 0.000000000003615 70.0
HKD2_k127_2579985_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 8.119e-316 989.0
HKD2_k127_2579985_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 9.158e-244 774.0
HKD2_k127_2579985_10 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000836 81.0
HKD2_k127_2579985_2 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 366.0
HKD2_k127_2579985_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 314.0
HKD2_k127_2579985_4 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001002 245.0
HKD2_k127_2579985_5 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000001119 192.0
HKD2_k127_2579985_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000002645 172.0
HKD2_k127_2579985_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000001159 128.0
HKD2_k127_2579985_8 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379,K18360 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0043085,GO:0043546,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050790,GO:0065007,GO:0065009,GO:0097159,GO:0097163,GO:0140104,GO:1901363 - 0.0000000000000000000000000000001097 138.0
HKD2_k127_2579985_9 Methyltransferase domain - - - 0.000000000000000000005733 106.0
HKD2_k127_2584221_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 7.84e-299 936.0
HKD2_k127_2584221_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.126e-298 924.0
HKD2_k127_2584221_10 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 305.0
HKD2_k127_2584221_11 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002692 280.0
HKD2_k127_2584221_12 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005731 248.0
HKD2_k127_2584221_13 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000008444 248.0
HKD2_k127_2584221_14 (Rhomboid) family - - - 0.0000000000000000000000000000000000000000000000000000000000003424 235.0
HKD2_k127_2584221_15 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000001068 218.0
HKD2_k127_2584221_16 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000002811 198.0
HKD2_k127_2584221_17 - - - - 0.000000000000000000000000000000000000000000000000000009219 202.0
HKD2_k127_2584221_18 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000001836 201.0
HKD2_k127_2584221_19 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000003996 181.0
HKD2_k127_2584221_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 6.144e-238 751.0
HKD2_k127_2584221_20 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000004894 177.0
HKD2_k127_2584221_21 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000011 166.0
HKD2_k127_2584221_22 Evidence 4 Homologs of previously reported genes of K21440 - - 0.000000000000000000000000000000000000000005737 164.0
HKD2_k127_2584221_23 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000002179 145.0
HKD2_k127_2584221_24 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000001573 138.0
HKD2_k127_2584221_25 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000001364 109.0
HKD2_k127_2584221_26 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000001309 85.0
HKD2_k127_2584221_27 deacetylase K22135 - - 0.000000000000002061 85.0
HKD2_k127_2584221_28 oxidoreductase activity - - - 0.0000000000006814 80.0
HKD2_k127_2584221_29 Domain of unknown function (DUF4286) - - - 0.000000000001283 73.0
HKD2_k127_2584221_3 Aminotransferase class-III - - - 2.314e-199 631.0
HKD2_k127_2584221_30 oligosaccharyl transferase activity - - - 0.00000000009591 76.0
HKD2_k127_2584221_31 Methyltransferase type 11 - - - 0.0000000001939 67.0
HKD2_k127_2584221_4 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 551.0
HKD2_k127_2584221_5 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 494.0
HKD2_k127_2584221_6 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 445.0
HKD2_k127_2584221_7 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 367.0
HKD2_k127_2584221_8 UMP kinase activity K09903 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 325.0
HKD2_k127_2584221_9 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 338.0
HKD2_k127_258429_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 1.035e-259 823.0
HKD2_k127_258429_1 Abc transporter K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 320.0
HKD2_k127_258429_2 PFAM 2Fe-2S -binding K03518,K07302,K13483 - 1.2.5.3,1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000001981 229.0
HKD2_k127_258429_3 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000003984 243.0
HKD2_k127_258429_4 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000001451 164.0
HKD2_k127_258429_5 photosynthesis K02453,K20543 - - 0.00000000000000000000000000000000000000006948 166.0
HKD2_k127_258429_6 Hemerythrin HHE cation binding - - - 0.00000000000000000000000000000000002374 146.0
HKD2_k127_258429_7 Tetratricopeptide repeat - - - 0.000000000007087 78.0
HKD2_k127_2589235_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 3.593e-240 752.0
HKD2_k127_2589235_1 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 368.0
HKD2_k127_2589235_2 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 369.0
HKD2_k127_2589235_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000006407 258.0
HKD2_k127_2589235_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000008775 205.0
HKD2_k127_2589235_5 C-terminal, D2-small domain, of ClpB protein K03694 - - 0.00000000000000000000000000000000000000000000000000008949 199.0
HKD2_k127_2589235_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000006647 131.0
HKD2_k127_2589235_7 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000000000000000000000000003338 129.0
HKD2_k127_2589235_8 PASTA domain K12132 - 2.7.11.1 0.0000000000000000001452 100.0
HKD2_k127_2589235_9 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.000000000000000000222 92.0
HKD2_k127_2604791_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.197e-232 738.0
HKD2_k127_2604791_1 Belongs to the SIS family. GutQ KpsF subfamily K01627,K03281,K06041 - 2.5.1.55,5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007129 359.0
HKD2_k127_2604791_2 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 340.0
HKD2_k127_2604791_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002381 269.0
HKD2_k127_2604791_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000003337 255.0
HKD2_k127_2604791_5 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 0.000000000000000000000000000000000000000000004948 168.0
HKD2_k127_2604791_6 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000003224 129.0
HKD2_k127_2604791_7 Bacterial regulatory proteins, tetR family - - - 0.00000000003209 68.0
HKD2_k127_2604791_8 Transcriptional regulator - - - 0.00000003922 61.0
HKD2_k127_2610656_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1317.0
HKD2_k127_2610656_1 PFAM Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 444.0
HKD2_k127_2610656_10 DinB family - - - 0.00000000000000000000000000001164 129.0
HKD2_k127_2610656_11 protein related to plant photosystem II stability assembly factor - - - 0.000000003432 67.0
HKD2_k127_2610656_12 response regulator - - - 0.00004545 51.0
HKD2_k127_2610656_2 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 422.0
HKD2_k127_2610656_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 375.0
HKD2_k127_2610656_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18302 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002139 284.0
HKD2_k127_2610656_5 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000024 229.0
HKD2_k127_2610656_6 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000003293 222.0
HKD2_k127_2610656_7 Serine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000008283 186.0
HKD2_k127_2610656_8 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000002136 157.0
HKD2_k127_2610656_9 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000008284 128.0
HKD2_k127_2613078_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.336e-256 810.0
HKD2_k127_2613078_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000174 246.0
HKD2_k127_2613078_2 Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000000000172 237.0
HKD2_k127_2613078_3 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.000000000000000000000000000000000000000000000000000000007364 206.0
HKD2_k127_2613078_4 PFAM Methyltransferase domain - - - 0.000000000000000000000000000000000000000000003489 184.0
HKD2_k127_2613078_5 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000000000000001969 135.0
HKD2_k127_2613078_6 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000001553 118.0
HKD2_k127_2613078_7 mttA/Hcf106 family K03116 - - 0.0000000000000002581 79.0
HKD2_k127_2613078_8 Transcriptional regulator, Crp Fnr family( K21562 - - 0.00000000003583 77.0
HKD2_k127_2613078_9 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.000009347 56.0
HKD2_k127_2614602_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 592.0
HKD2_k127_2614602_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000115 77.0
HKD2_k127_262077_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006547 338.0
HKD2_k127_262077_1 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000006548 140.0
HKD2_k127_262077_2 haloacid dehalogenase-like hydrolase K06019 - 3.6.1.1 0.0000000000000000000000000000002028 132.0
HKD2_k127_262077_3 Hydrolase, P-loop family K06925 - - 0.0000000000000000000000004548 113.0
HKD2_k127_262077_4 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000035 95.0
HKD2_k127_262077_5 Peptidase M56 K03646 - - 0.00000000000000002156 95.0
HKD2_k127_262077_6 FHA domain protein - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.00000000009234 74.0
HKD2_k127_262077_7 Prokaryotic RING finger family 1 - - - 0.0001746 48.0
HKD2_k127_2622879_0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000549 251.0
HKD2_k127_2622879_1 - - - - 0.0001145 55.0
HKD2_k127_2629777_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 443.0
HKD2_k127_2629777_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 424.0
HKD2_k127_2629777_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 311.0
HKD2_k127_2629777_3 Tetratricopeptide repeat K20543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006725 271.0
HKD2_k127_264270_0 Glycosyltransferase like family 2 K07011,K20444 - - 0.000000000000000000000000000000000000000000000000000000001493 207.0
HKD2_k127_264270_1 PFAM Dockerin type - - - 0.000000000000000005071 95.0
HKD2_k127_2671141_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 5.146e-252 794.0
HKD2_k127_2671141_1 Insulinase (Peptidase family M16) - - - 8.274e-207 652.0
HKD2_k127_2671141_2 Aldo/keto reductase family K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 510.0
HKD2_k127_2671141_3 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase K00322 - 1.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 499.0
HKD2_k127_2671141_4 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 472.0
HKD2_k127_2671141_5 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 401.0
HKD2_k127_2671141_6 Cupin domain - - - 0.00000000000000000000000000000000000000000000008354 170.0
HKD2_k127_2671141_7 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000000002077 111.0
HKD2_k127_2671141_8 Redoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0001603 46.0
HKD2_k127_2671407_0 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 408.0
HKD2_k127_2671407_1 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000001486 157.0
HKD2_k127_2671407_2 exo-alpha-(2->6)-sialidase activity - - - 0.000000000008552 74.0
HKD2_k127_2707091_0 Oligoendopeptidase f - - - 1.367e-268 845.0
HKD2_k127_2707091_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000001483 139.0
HKD2_k127_2707091_2 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000003922 144.0
HKD2_k127_2707091_3 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.00000000000000000000000000000007076 137.0
HKD2_k127_2707091_4 chitinase K01183 - 3.2.1.14 0.0000000000000000000000000000002134 138.0
HKD2_k127_2707091_5 PPIC-type PPIASE domain K03769,K07533 - 5.2.1.8 0.0001778 53.0
HKD2_k127_2716504_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 2.207e-317 1066.0
HKD2_k127_2716504_1 Inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 311.0
HKD2_k127_2716504_2 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000002998 246.0
HKD2_k127_2716504_3 Kelch-like protein K10459 GO:0000070,GO:0000075,GO:0000151,GO:0000278,GO:0000280,GO:0000819,GO:0000922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005827,GO:0005829,GO:0005856,GO:0005874,GO:0005876,GO:0006464,GO:0006513,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007088,GO:0007093,GO:0007094,GO:0007346,GO:0008150,GO:0008152,GO:0009987,GO:0010564,GO:0010639,GO:0010948,GO:0010965,GO:0015630,GO:0016043,GO:0016567,GO:0019538,GO:0022402,GO:0030071,GO:0031461,GO:0031463,GO:0031577,GO:0032446,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033046,GO:0033047,GO:0033048,GO:0036211,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0045786,GO:0045839,GO:0045841,GO:0045930,GO:0048285,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051276,GO:0051301,GO:0051726,GO:0051783,GO:0051784,GO:0051983,GO:0051985,GO:0065007,GO:0070647,GO:0071173,GO:0071174,GO:0071704,GO:0071840,GO:0072686,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0140014,GO:1901564,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902099,GO:1902100,GO:1902494,GO:1903047,GO:1905818,GO:1905819,GO:1990234,GO:2000816,GO:2001251 - 0.00000000000000001261 100.0
HKD2_k127_2716504_4 Subtilase family - - - 0.0000000000005572 85.0
HKD2_k127_2723514_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000009926 177.0
HKD2_k127_2723514_1 MotA TolQ ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000001361 159.0
HKD2_k127_2723514_2 Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000071 106.0
HKD2_k127_2723514_3 phosphorelay signal transduction system K07658 - - 0.000000000001594 81.0
HKD2_k127_2723514_4 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000271 55.0
HKD2_k127_273680_0 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 438.0
HKD2_k127_273680_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006252 411.0
HKD2_k127_273680_10 - - - - 0.0005454 52.0
HKD2_k127_273680_2 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 306.0
HKD2_k127_273680_3 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004264 284.0
HKD2_k127_273680_4 Metallo-beta-lactamase superfamily K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000001342 272.0
HKD2_k127_273680_5 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000001033 214.0
HKD2_k127_273680_6 Macrocin-O-methyltransferase (TylF) - - - 0.0000000000000000000000000000000000000000000008615 178.0
HKD2_k127_273680_7 - - - - 0.000000000000000001557 96.0
HKD2_k127_273680_8 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000003863 91.0
HKD2_k127_273680_9 - - - - 0.00001534 56.0
HKD2_k127_2736982_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 354.0
HKD2_k127_2736982_2 TIGRFAM Pseudaminic acid biosynthesis-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000002048 236.0
HKD2_k127_2765065_0 Leukotriene A-4 hydrolase K01254 GO:0003674,GO:0003824,GO:0004177,GO:0004301,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016801,GO:0016803,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 439.0
HKD2_k127_2765065_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000005212 79.0
HKD2_k127_2765065_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000128 54.0
HKD2_k127_2817806_0 lipopolysaccharide transport K22110 - - 0.0 1388.0
HKD2_k127_2817806_1 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 571.0
HKD2_k127_2817806_2 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 552.0
HKD2_k127_2817806_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 439.0
HKD2_k127_2817806_4 Dehydrogenase - - - 0.000000000000000001081 85.0
HKD2_k127_2817806_5 Putative zinc-finger - - - 0.000000155 57.0
HKD2_k127_2833644_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 9.519e-195 614.0
HKD2_k127_2833644_1 tRNA nucleotidyltransferase poly(A) polymerase K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 619.0
HKD2_k127_2833644_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 563.0
HKD2_k127_2833644_3 Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 372.0
HKD2_k127_2833644_4 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000000000000006769 149.0
HKD2_k127_2833644_5 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000001971 88.0
HKD2_k127_2833644_6 - K02275,K17686 - 1.9.3.1,3.6.3.54 0.000000000000001565 82.0
HKD2_k127_2833644_7 antisigma factor binding K04749 - - 0.000002324 59.0
HKD2_k127_2864215_0 DNA polymerase alpha chain like domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 547.0
HKD2_k127_2864215_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007602 499.0
HKD2_k127_2864215_10 PFAM Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008448 310.0
HKD2_k127_2864215_11 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 292.0
HKD2_k127_2864215_12 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000009931 268.0
HKD2_k127_2864215_13 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000217 268.0
HKD2_k127_2864215_14 amine dehydrogenase activity K14647,K21449 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007962 264.0
HKD2_k127_2864215_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000004433 251.0
HKD2_k127_2864215_16 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000008209 231.0
HKD2_k127_2864215_17 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000005116 228.0
HKD2_k127_2864215_18 Biotin/lipoate A/B protein ligase family K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000002406 219.0
HKD2_k127_2864215_19 Methyltransferase domain K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000003727 212.0
HKD2_k127_2864215_2 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 497.0
HKD2_k127_2864215_20 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000002122 188.0
HKD2_k127_2864215_21 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000004066 162.0
HKD2_k127_2864215_22 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000009101 102.0
HKD2_k127_2864215_23 Rieske-like [2Fe-2S] domain K00363 - 1.7.1.15 0.0000000000000003489 85.0
HKD2_k127_2864215_24 Sortilin, neurotensin receptor 3, - - - 0.000000000009346 76.0
HKD2_k127_2864215_25 Rhodanese Homology Domain - - - 0.000000002291 59.0
HKD2_k127_2864215_3 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 420.0
HKD2_k127_2864215_4 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009582 383.0
HKD2_k127_2864215_5 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 383.0
HKD2_k127_2864215_6 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 364.0
HKD2_k127_2864215_7 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 357.0
HKD2_k127_2864215_8 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007922 347.0
HKD2_k127_2864215_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 319.0
HKD2_k127_2867729_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 483.0
HKD2_k127_2867729_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000006692 200.0
HKD2_k127_2867729_2 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000008267 111.0
HKD2_k127_2867729_4 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.00000004824 56.0
HKD2_k127_2867729_5 copG family - - - 0.000007312 51.0
HKD2_k127_2871393_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.48e-226 727.0
HKD2_k127_2871393_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 424.0
HKD2_k127_2871393_2 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 409.0
HKD2_k127_2871393_3 collagen metabolic process K08677 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 351.0
HKD2_k127_2871393_4 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 299.0
HKD2_k127_2875780_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 580.0
HKD2_k127_2875780_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 447.0
HKD2_k127_2875780_2 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 386.0
HKD2_k127_2875780_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001088 285.0
HKD2_k127_2875780_4 RNA-DNA hybrid ribonuclease activity K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000003707 216.0
HKD2_k127_2875780_5 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000004033 204.0
HKD2_k127_2875780_6 peptidyl-tyrosine sulfation K00525,K01768 - 1.17.4.1,4.6.1.1 0.000000000000000000000000000000000000000000346 168.0
HKD2_k127_2875780_7 Surface antigen - - - 0.00000000000000000000000004769 123.0
HKD2_k127_2875780_8 - - - - 0.0000000005318 70.0
HKD2_k127_2889087_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 539.0
HKD2_k127_2889087_1 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 527.0
HKD2_k127_2889087_10 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000003695 164.0
HKD2_k127_2889087_12 Caspase domain - - - 0.00000001505 67.0
HKD2_k127_2889087_2 metallocarboxypeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 501.0
HKD2_k127_2889087_3 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 463.0
HKD2_k127_2889087_4 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 419.0
HKD2_k127_2889087_5 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 376.0
HKD2_k127_2889087_6 Belongs to the Pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 353.0
HKD2_k127_2889087_7 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 312.0
HKD2_k127_2889087_8 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001744 300.0
HKD2_k127_2889087_9 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000001986 176.0
HKD2_k127_2906369_0 dCMP deaminase activity K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000007592 201.0
HKD2_k127_2906369_1 AAA domain - - - 0.00000000000000000000000000001923 130.0
HKD2_k127_2906369_2 - - - - 0.0000000000000000000007286 108.0
HKD2_k127_2920733_0 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 322.0
HKD2_k127_2920733_1 phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000003815 236.0
HKD2_k127_2920733_2 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.000004319 50.0
HKD2_k127_2935004_0 FAD linked oxidases, C-terminal domain K00104,K18930 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 609.0
HKD2_k127_2935004_1 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009696 332.0
HKD2_k127_2935004_2 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000003803 179.0
HKD2_k127_2935004_3 Crp-like helix-turn-helix domain K10914 - - 0.00000000000000000000000000000000000000000000008264 177.0
HKD2_k127_2935004_4 oxidoreductase FAD NAD(P)-binding K00523,K00528 - 1.17.1.1,1.18.1.2,1.19.1.1 0.0000000000000000001371 100.0
HKD2_k127_2935004_5 Domain of unknown function (DUF4388) - - - 0.00000000000000002546 96.0
HKD2_k127_2935004_6 Tetratricopeptide repeat protein - - - 0.000007548 57.0
HKD2_k127_2949077_0 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 443.0
HKD2_k127_2949077_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 350.0
HKD2_k127_2949077_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005924 321.0
HKD2_k127_2949077_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07713 GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002471 303.0
HKD2_k127_2963975_0 alpha-galactosidase - - - 1.888e-262 824.0
HKD2_k127_2963975_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 515.0
HKD2_k127_2963975_2 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 452.0
HKD2_k127_2963975_3 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000004429 227.0
HKD2_k127_2963975_4 alpha beta K06889 - - 0.000000000000000000000000000000000000000000000105 187.0
HKD2_k127_2963975_5 DinB family - - - 0.00000000000000000000001724 106.0
HKD2_k127_2963975_6 Involved in the tonB-independent uptake of proteins - - - 0.0001356 53.0
HKD2_k127_2984097_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 473.0
HKD2_k127_2984097_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 450.0
HKD2_k127_2984097_2 Large family of predicted nucleotide-binding domains - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 360.0
HKD2_k127_2984097_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775,K18348 - 5.1.1.1,5.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001831 281.0
HKD2_k127_2984097_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000004399 255.0
HKD2_k127_2984097_5 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000001043 154.0
HKD2_k127_2984097_6 Ribosomal protein S18 K02963 - - 0.00000000000000000000008889 100.0
HKD2_k127_2984097_7 BON domain - - - 0.00000000000000005354 92.0
HKD2_k127_2984097_8 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000007223 70.0
HKD2_k127_2989057_0 penicillin amidase K01434 - 3.5.1.11 1.33e-322 1005.0
HKD2_k127_2989057_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005445 283.0
HKD2_k127_2989057_2 nitric oxide dioxygenase activity - - - 0.000000000000000000000000000000000000001141 151.0
HKD2_k127_2989057_3 Amino acid permease - - - 0.0000000000000000000000001346 111.0
HKD2_k127_2994799_0 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 451.0
HKD2_k127_2994799_1 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 416.0
HKD2_k127_2994799_2 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001875 261.0
HKD2_k127_2994799_3 cyclic nucleotide binding K00925 - 2.7.2.1 0.0000003021 61.0
HKD2_k127_2994799_4 ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00003201 52.0
HKD2_k127_3003868_0 Ferrous iron transport protein B K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 581.0
HKD2_k127_3003868_1 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 562.0
HKD2_k127_3003868_10 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000001806 147.0
HKD2_k127_3003868_11 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000000001391 151.0
HKD2_k127_3003868_12 zinc-ribbon domain - - - 0.00000000000000000000000000000003834 138.0
HKD2_k127_3003868_13 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000564 134.0
HKD2_k127_3003868_14 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000003436 134.0
HKD2_k127_3003868_15 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000004659 119.0
HKD2_k127_3003868_17 FeoA K04758 - - 0.00000000304 61.0
HKD2_k127_3003868_2 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 346.0
HKD2_k127_3003868_3 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 303.0
HKD2_k127_3003868_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 300.0
HKD2_k127_3003868_5 Pfam:Arch_ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002568 265.0
HKD2_k127_3003868_6 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006428 264.0
HKD2_k127_3003868_7 regulator, PATAN and FRGAF domain-containing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001058 280.0
HKD2_k127_3003868_8 HEAT repeat - - - 0.000000000000000000000000000000000000000000002173 188.0
HKD2_k127_3003868_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000008597 156.0
HKD2_k127_302537_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 456.0
HKD2_k127_302537_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000002325 227.0
HKD2_k127_302537_2 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000002485 224.0
HKD2_k127_302537_3 Response regulator receiver domain - - - 0.000000000000000000000000000000000000000019 156.0
HKD2_k127_302537_4 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000001936 132.0
HKD2_k127_302537_5 Domain of unknown function (DUF309) K09763 - - 0.0000000000000000001931 94.0
HKD2_k127_302537_6 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000005909 54.0
HKD2_k127_3034209_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008446 538.0
HKD2_k127_3034209_1 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000001366 248.0
HKD2_k127_3034209_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000001169 201.0
HKD2_k127_3034209_3 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000002944 78.0
HKD2_k127_30381_0 peptidase - - - 6.095e-259 814.0
HKD2_k127_30381_1 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 558.0
HKD2_k127_30381_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001207 284.0
HKD2_k127_30381_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002157 287.0
HKD2_k127_30381_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000002942 220.0
HKD2_k127_30381_5 - - - - 0.00000000000000009813 85.0
HKD2_k127_30381_6 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000005037 72.0
HKD2_k127_30381_7 Putative esterase K07017 - - 0.00000004063 66.0
HKD2_k127_3048441_0 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000000000000000000000000000000000003193 229.0
HKD2_k127_3048441_1 cellulose binding - - - 0.000000000000000000001039 111.0
HKD2_k127_3048441_2 Sortilin, neurotensin receptor 3, - - - 0.000000005824 68.0
HKD2_k127_3112027_0 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 307.0
HKD2_k127_3112027_1 Leucine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006033 246.0
HKD2_k127_3112027_2 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000003441 230.0
HKD2_k127_3112027_3 calcium- and calmodulin-responsive adenylate cyclase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000554 218.0
HKD2_k127_3112027_4 COG0666 FOG Ankyrin repeat K06867 - - 0.0000000000000000000000000978 118.0
HKD2_k127_3112027_5 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000003444 100.0
HKD2_k127_3194644_0 SMART Elongator protein 3 MiaB NifB - - - 5.063e-201 656.0
HKD2_k127_3194644_1 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 487.0
HKD2_k127_3194644_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000003922 169.0
HKD2_k127_3216148_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 398.0
HKD2_k127_3216148_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000006092 246.0
HKD2_k127_3216148_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000002311 174.0
HKD2_k127_3216148_3 chitin binding - - - 0.0000000000000000000001783 112.0
HKD2_k127_3216148_4 PFAM Protein kinase domain K08884 - 2.7.11.1 0.0000001242 59.0
HKD2_k127_3216148_5 - - - - 0.0000001567 64.0
HKD2_k127_3216148_6 heat shock protein binding K05516,K05801 - - 0.0003987 44.0
HKD2_k127_3219645_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. K12266 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 521.0
HKD2_k127_3219645_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 535.0
HKD2_k127_3219645_2 Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions K07322 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000002038 208.0
HKD2_k127_3219645_3 Cupin 2, conserved barrel domain protein K18991 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617 - 0.0000000000000000000000000002931 119.0
HKD2_k127_3219645_4 amine dehydrogenase activity - - - 0.000000000000000000000000003164 123.0
HKD2_k127_3219645_5 Ankyrin repeat - - - 0.000000000008022 70.0
HKD2_k127_3222033_0 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003787 299.0
HKD2_k127_3222033_1 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000005773 145.0
HKD2_k127_3222033_2 TIGRFAM VWFA-related Acidobacterial domain K07114 - - 0.000000000004912 77.0
HKD2_k127_3222033_3 - - - - 0.000001682 59.0
HKD2_k127_3234198_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 4.968e-288 893.0
HKD2_k127_3234198_1 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 5.458e-198 649.0
HKD2_k127_3234198_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000002594 233.0
HKD2_k127_3234198_11 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000003127 216.0
HKD2_k127_3234198_12 PFAM Appr-1-p processing domain protein - - - 0.000000000000000000000000000000000000000000000000000000000195 210.0
HKD2_k127_3234198_13 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000009014 190.0
HKD2_k127_3234198_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000004046 164.0
HKD2_k127_3234198_15 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000006092 165.0
HKD2_k127_3234198_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000004547 151.0
HKD2_k127_3234198_17 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.00000000000000000000000000000000000007043 149.0
HKD2_k127_3234198_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000000003225 123.0
HKD2_k127_3234198_19 PFAM Ubiquitin-conjugating - - - 0.0000000000000000000000004628 115.0
HKD2_k127_3234198_2 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 596.0
HKD2_k127_3234198_20 PFAM Mov34 MPN PAD-1 family - - - 0.0000000000000000000001318 106.0
HKD2_k127_3234198_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000008682 98.0
HKD2_k127_3234198_22 PspC domain protein - - - 0.0000000000000000001281 93.0
HKD2_k127_3234198_23 WXG100 protein secretion system (Wss), protein YukD - - - 0.00000000000004392 76.0
HKD2_k127_3234198_24 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.000000005312 65.0
HKD2_k127_3234198_25 Tricorn protease homolog K08676 - - 0.0000001333 63.0
HKD2_k127_3234198_3 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006061 471.0
HKD2_k127_3234198_4 NAD binding K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 458.0
HKD2_k127_3234198_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 366.0
HKD2_k127_3234198_6 quinone binding K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 363.0
HKD2_k127_3234198_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 343.0
HKD2_k127_3234198_8 PFAM UBA THIF-type NAD FAD binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002073 287.0
HKD2_k127_3234198_9 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007351 258.0
HKD2_k127_3254237_0 PFAM GlcNAc-PI de-N-acetylase - - - 1.327e-256 816.0
HKD2_k127_3254237_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007146 605.0
HKD2_k127_3254237_10 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000004919 128.0
HKD2_k127_3254237_11 oxidoreductase activity - - - 0.0000007639 61.0
HKD2_k127_3254237_2 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 583.0
HKD2_k127_3254237_3 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 317.0
HKD2_k127_3254237_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000004168 246.0
HKD2_k127_3254237_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000008182 241.0
HKD2_k127_3254237_6 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000008609 250.0
HKD2_k127_3254237_7 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000005282 231.0
HKD2_k127_3254237_8 acr, cog1993 K06199,K09137 - - 0.00000000000000000000000000000000003236 138.0
HKD2_k127_3254237_9 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000005255 136.0
HKD2_k127_3258705_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000006316 186.0
HKD2_k127_3258705_1 YCII-related domain - - - 0.00000000000000000000000000000000000000003873 157.0
HKD2_k127_3258705_2 Ion channel - - - 0.00000000000000000000000000000000000005011 152.0
HKD2_k127_3258705_3 Rhodanese Homology Domain - - - 0.0000000000000000000000004654 113.0
HKD2_k127_3258705_4 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000654 105.0
HKD2_k127_3258705_5 PFAM Hemerythrin HHE cation binding domain - - - 0.000000000001769 74.0
HKD2_k127_3269181_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1101.0
HKD2_k127_3269181_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 532.0
HKD2_k127_3269181_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000874 144.0
HKD2_k127_330147_0 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 512.0
HKD2_k127_330147_1 Beta-lactamase class C - - - 0.000000000000000000000000000000000000000000000000000000000000000005279 238.0
HKD2_k127_330147_2 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000000000001197 156.0
HKD2_k127_330147_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000001524 163.0
HKD2_k127_3324093_0 Peptidase family M28 - - - 3.429e-218 707.0
HKD2_k127_3324093_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 422.0
HKD2_k127_3324093_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 328.0
HKD2_k127_3324093_3 Polysaccharide export protein K01991,K20988 - - 0.00000000000000000000000000000000000000000000000000000000000000001002 239.0
HKD2_k127_332483_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 288.0
HKD2_k127_332483_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000004942 164.0
HKD2_k127_332483_2 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000002113 147.0
HKD2_k127_332483_3 Belongs to the ompA family - - - 0.00000000000000000000000000000000524 135.0
HKD2_k127_332483_4 PFAM von Willebrand factor type A - - - 0.00000000000000000000000004538 119.0
HKD2_k127_3331982_0 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 600.0
HKD2_k127_3331982_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 324.0
HKD2_k127_3331982_2 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000224 227.0
HKD2_k127_3331982_3 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000007751 217.0
HKD2_k127_3331982_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000003093 192.0
HKD2_k127_3331982_5 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000008607 154.0
HKD2_k127_3331982_6 - - - - 0.0000000524 66.0
HKD2_k127_3448397_0 Amidohydrolase family - - - 2.465e-233 736.0
HKD2_k127_3448397_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 437.0
HKD2_k127_3448397_10 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000002108 123.0
HKD2_k127_3448397_11 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000002162 111.0
HKD2_k127_3448397_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 395.0
HKD2_k127_3448397_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 323.0
HKD2_k127_3448397_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 295.0
HKD2_k127_3448397_5 PFAM glycosyl transferase family 2 K14597 - - 0.00000000000000000000000000000000000000000000000000003251 203.0
HKD2_k127_3448397_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000008593 193.0
HKD2_k127_3448397_7 GHMP kinases C terminal - - - 0.00000000000000000000000000000000000000000000000000372 193.0
HKD2_k127_3448397_8 Sulfatase - - - 0.000000000000000000000000000000000000000000000000004968 205.0
HKD2_k127_3448397_9 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000003702 143.0
HKD2_k127_3475914_0 radical SAM domain protein - - - 5.031e-218 692.0
HKD2_k127_3475914_1 protein histidine kinase activity K03271 - 5.3.1.28 0.000000000000000000000001185 116.0
HKD2_k127_3475914_2 PQQ-like domain - - - 0.00000000000000003178 96.0
HKD2_k127_3475914_3 Protein kinase domain K12132 - 2.7.11.1 0.0000000000005421 76.0
HKD2_k127_3487011_0 Peptidase family M3 K01284 - 3.4.15.5 9.049e-305 952.0
HKD2_k127_3487011_1 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 288.0
HKD2_k127_3487011_2 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000339 119.0
HKD2_k127_3487011_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00003493 50.0
HKD2_k127_34914_0 PFAM ABC transporter related K06020 - 3.6.3.25 2.948e-294 910.0
HKD2_k127_34914_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 492.0
HKD2_k127_34914_2 PFAM Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 449.0
HKD2_k127_34914_3 - - - - 0.00000000000000000000000000006592 119.0
HKD2_k127_34914_4 Carboxypeptidase regulatory-like domain - - - 0.000003179 53.0
HKD2_k127_3517968_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 400.0
HKD2_k127_3517968_1 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006991 276.0
HKD2_k127_3517968_2 Rhomboid family K07059 - - 0.0000000000000000000000000000000000000000000000000000000000000000001092 237.0
HKD2_k127_3517968_3 Predicted membrane protein (DUF2238) K08984 - - 0.000000000002084 67.0
HKD2_k127_3534305_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 288.0
HKD2_k127_3534305_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000004753 227.0
HKD2_k127_3534305_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000001552 178.0
HKD2_k127_3540736_0 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 550.0
HKD2_k127_3540736_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 497.0
HKD2_k127_3540736_10 TolA binding protein trimerisation - - - 0.00006543 49.0
HKD2_k127_3540736_2 Glycyl-tRNA synthetase, alpha subunit K01878,K14164 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 407.0
HKD2_k127_3540736_3 PFAM Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001122 262.0
HKD2_k127_3540736_4 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000002298 190.0
HKD2_k127_3540736_5 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.00000000000000000000000000000000000001437 150.0
HKD2_k127_3540736_6 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000004365 152.0
HKD2_k127_3540736_7 Involved in DNA repair and RecF pathway recombination K03474,K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 0.00000000000000000000000000003765 128.0
HKD2_k127_3540736_8 Tfp pilus assembly protein FimV - - - 0.0000000000000000000305 102.0
HKD2_k127_3540736_9 Tetratricopeptide TPR_2 repeat protein - - - 0.000001662 61.0
HKD2_k127_3547703_0 TIGRFAM Aspartate kinase K12524 - 1.1.1.3,2.7.2.4 1.33e-264 838.0
HKD2_k127_3547703_1 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 468.0
HKD2_k127_3547703_2 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000004285 242.0
HKD2_k127_3547703_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000003457 224.0
HKD2_k127_3547703_4 Cupin superfamily (DUF985) - - - 0.00000000000000000000000000000000000000002972 156.0
HKD2_k127_3576575_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 479.0
HKD2_k127_3576575_1 LuxR family transcriptional regulator K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000005896 229.0
HKD2_k127_3576575_2 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000003124 228.0
HKD2_k127_3576575_3 - - - - 0.000000000000000000000000000000000000000000000000000000007593 205.0
HKD2_k127_3576575_4 - - - - 0.000000000000000000000000000000000000000000000002965 190.0
HKD2_k127_3576575_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000003446 170.0
HKD2_k127_3576575_6 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000003815 150.0
HKD2_k127_3576575_7 3 beta-hydroxysteroid dehydrogenase type 7 K00070,K12408 GO:0001558,GO:0001889,GO:0002376,GO:0003674,GO:0003824,GO:0003854,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0006066,GO:0006082,GO:0006629,GO:0006694,GO:0006699,GO:0006706,GO:0006707,GO:0006928,GO:0006935,GO:0007275,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008206,GO:0008610,GO:0009056,GO:0009058,GO:0009605,GO:0009987,GO:0012505,GO:0016020,GO:0016042,GO:0016053,GO:0016125,GO:0016127,GO:0016229,GO:0016477,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030595,GO:0031099,GO:0031100,GO:0031984,GO:0032501,GO:0032502,GO:0032787,GO:0033764,GO:0035754,GO:0040008,GO:0040011,GO:0042175,GO:0042221,GO:0042330,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046164,GO:0046394,GO:0047016,GO:0048247,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0048870,GO:0050789,GO:0050794,GO:0050896,GO:0050900,GO:0051128,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0060326,GO:0061008,GO:0065007,GO:0070887,GO:0071704,GO:0072330,GO:0072676,GO:0097421,GO:0098827,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1902652 1.1.1.145,1.1.1.181,5.3.3.1 0.00007774 45.0
HKD2_k127_3579283_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 4.212e-214 688.0
HKD2_k127_3579283_1 PFAM Metal-dependent phosphohydrolase, HD K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 428.0
HKD2_k127_3579283_10 Domain of unknown function (DUF1877) - - - 0.0000000052 65.0
HKD2_k127_3579283_11 Cytochrome P460 - - - 0.00007258 52.0
HKD2_k127_3579283_12 Protein of unknown function (DUF3592) - - - 0.000888 49.0
HKD2_k127_3579283_2 Belongs to the LDH MDH superfamily. LDH family K00016 - 1.1.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 307.0
HKD2_k127_3579283_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001815 280.0
HKD2_k127_3579283_5 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000006785 180.0
HKD2_k127_3579283_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000001656 153.0
HKD2_k127_3579283_7 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.00000000000000000000000000000000003031 144.0
HKD2_k127_3579283_8 Transcriptional regulator - - - 0.00000000000000000000000000006374 120.0
HKD2_k127_3579283_9 - - - - 0.0000000000001017 76.0
HKD2_k127_3592404_0 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 1.509e-213 676.0
HKD2_k127_3592404_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 467.0
HKD2_k127_3592404_2 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 370.0
HKD2_k127_3592404_3 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.00000000000000000000000000000000000000000000000004955 188.0
HKD2_k127_3614171_0 Oligopeptidase F K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 417.0
HKD2_k127_3614171_1 PFAM Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000598 251.0
HKD2_k127_3614171_2 Nucleoside-binding outer membrane - - - 0.0000000000000000000000000000000000000000001903 175.0
HKD2_k127_3614171_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000129 134.0
HKD2_k127_3614171_4 methyltransferase - - - 0.0000000000000000000003964 103.0
HKD2_k127_3624038_0 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 576.0
HKD2_k127_3624038_1 O-methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000005086 171.0
HKD2_k127_3624038_2 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000008404 63.0
HKD2_k127_3624038_3 Beta-lactamase - - - 0.0000002026 59.0
HKD2_k127_3637301_0 beta-lactamase domain protein K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000005958 258.0
HKD2_k127_3637301_1 TonB dependent receptor K02014 - - 0.0000001051 59.0
HKD2_k127_3637301_2 Glycosyl hydrolases family 16 K01179 - 3.2.1.4 0.000722 51.0
HKD2_k127_3661167_0 von Willebrand factor, type A K07114 - - 8.222e-230 731.0
HKD2_k127_3661167_1 transcription factor binding K15836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 509.0
HKD2_k127_3661167_10 methyltransferase - - - 0.0000000001202 65.0
HKD2_k127_3661167_2 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 317.0
HKD2_k127_3661167_3 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000004678 221.0
HKD2_k127_3661167_4 PFAM Protein kinase K03413 - - 0.0000000000000000000000000000000000000000000000000000002 220.0
HKD2_k127_3661167_5 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.00000000000000000000000000000000000000001928 157.0
HKD2_k127_3661167_6 Glycosyltransferases involved in cell wall biogenesis-like protein - - - 0.00000000000000000000000000000000000001551 167.0
HKD2_k127_3661167_7 YceI-like domain - - - 0.00000000000000000000000000000526 131.0
HKD2_k127_3661167_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000004944 134.0
HKD2_k127_3661167_9 Sugar transferase K19428 - - 0.000000000000000007168 95.0
HKD2_k127_3681794_0 GMC oxidoreductase K03333 - 1.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 550.0
HKD2_k127_3681794_1 ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 381.0
HKD2_k127_3681794_2 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002183 252.0
HKD2_k127_3681794_3 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000002952 171.0
HKD2_k127_3681794_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000001442 121.0
HKD2_k127_3681794_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00002828 52.0
HKD2_k127_3688727_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1043.0
HKD2_k127_3688727_1 Trimethylamine methyltransferase K14083 - 2.1.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 432.0
HKD2_k127_3688727_2 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005054 269.0
HKD2_k127_3688727_3 SPFH domain-Band 7 family - - - 0.00000000000000000000008142 102.0
HKD2_k127_3688727_4 - - - - 0.000000000000000000007437 98.0
HKD2_k127_3730309_0 Permease YjgP YjgQ family protein K07091,K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 476.0
HKD2_k127_3730309_1 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003124 267.0
HKD2_k127_3730309_2 Glycosyl hydrolase family 57 - - - 0.0000000000000000000000000000000000000000000000000000000000000007445 226.0
HKD2_k127_3730309_3 Domain of unknown function (DUF4189) - - - 0.000000000000000004976 89.0
HKD2_k127_3731877_0 Endopeptidase La K04076 - 3.4.21.53 1.637e-225 717.0
HKD2_k127_3731877_1 Cytochrome c554 and c-prime - - - 6.123e-218 685.0
HKD2_k127_3731877_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 625.0
HKD2_k127_3731877_3 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 457.0
HKD2_k127_3731877_4 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 351.0
HKD2_k127_3731877_5 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 310.0
HKD2_k127_3731877_6 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001546 273.0
HKD2_k127_3731877_7 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000004074 203.0
HKD2_k127_3731877_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000005867 190.0
HKD2_k127_3758266_0 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 395.0
HKD2_k127_3758266_1 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000005934 224.0
HKD2_k127_3758266_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000006864 239.0
HKD2_k127_3758266_3 Parallel beta-helix repeats - - - 0.000000000000000000000000007897 129.0
HKD2_k127_379002_0 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 596.0
HKD2_k127_379002_1 40-residue YVTN family beta-propeller repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 513.0
HKD2_k127_379002_2 COG2939 Carboxypeptidase C (cathepsin A) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 466.0
HKD2_k127_379002_3 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 387.0
HKD2_k127_379002_4 Binding-protein-dependent transport system inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 362.0
HKD2_k127_379002_5 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000000000000000000000000000003213 238.0
HKD2_k127_379002_6 serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000004424 158.0
HKD2_k127_379951_0 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 469.0
HKD2_k127_379951_1 Beta-eliminating lyase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 440.0
HKD2_k127_379951_2 IstB-like ATP binding protein K02315 - - 0.00000000000000000000000000000000000000006568 162.0
HKD2_k127_379951_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.0000000000000000000000008001 111.0
HKD2_k127_379951_4 Tyrosine phosphatase family - - - 0.000000000000000000000617 101.0
HKD2_k127_379951_5 - - - - 0.00000000000000342 89.0
HKD2_k127_379951_6 IstB-like ATP binding protein K02315,K04076 - 3.4.21.53 0.0001563 52.0
HKD2_k127_3826378_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000003224 236.0
HKD2_k127_3826378_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000001288 143.0
HKD2_k127_3826378_2 Sulfatase - - - 0.00000000000000000000000004764 119.0
HKD2_k127_3862582_0 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000215 235.0
HKD2_k127_3862582_1 - - - - 0.0000000000000000000000000000000000000000000000000000001527 195.0
HKD2_k127_3862582_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000003806 216.0
HKD2_k127_3862582_3 Carboxypeptidase regulatory-like domain - - - 0.0000000004982 69.0
HKD2_k127_3865272_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1054.0
HKD2_k127_3865272_1 Belongs to the amidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 430.0
HKD2_k127_3865272_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000001135 142.0
HKD2_k127_3867201_0 COG3119 Arylsulfatase A and related enzymes K01130 - 3.1.6.1 0.0 1217.0
HKD2_k127_3867201_1 Cytochrome c554 and c-prime - - - 1.963e-217 696.0
HKD2_k127_3867201_10 - - - - 0.000000000000000000000000000000000000000000000001203 183.0
HKD2_k127_3867201_11 oxidoreductase activity, acting on diphenols and related substances as donors K02636 - 1.10.9.1 0.00000000000000000000000000000000000000000002462 166.0
HKD2_k127_3867201_12 PFAM Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000001709 143.0
HKD2_k127_3867201_13 long-chain fatty acid transport protein - - - 0.0000000000000000000000000000004617 133.0
HKD2_k127_3867201_14 Domain of unknown function (DUF4136) - - - 0.00000000000000000000000000000157 127.0
HKD2_k127_3867201_15 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000001195 98.0
HKD2_k127_3867201_16 Winged helix DNA-binding domain - - - 0.0000000000000000005476 95.0
HKD2_k127_3867201_17 PFAM FAD dependent oxidoreductase - - - 0.0003525 44.0
HKD2_k127_3867201_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.78e-212 669.0
HKD2_k127_3867201_3 cell wall organization - - - 1.478e-200 649.0
HKD2_k127_3867201_4 Protein kinase domain K12132 - 2.7.11.1 3.611e-198 657.0
HKD2_k127_3867201_5 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 496.0
HKD2_k127_3867201_6 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 379.0
HKD2_k127_3867201_7 PFAM Cytochrome b b6 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000965 370.0
HKD2_k127_3867201_8 SPFH domain-Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 296.0
HKD2_k127_3867201_9 PFAM Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000002208 257.0
HKD2_k127_3872751_0 TIGRFAM DNA polymerase III, alpha subunit K02337,K14162 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000002899 214.0
HKD2_k127_3872751_1 Methyltransferase small domain K15460 - 2.1.1.223 0.00000000000000000000000000000000000000006767 160.0
HKD2_k127_3872751_2 Serine aminopeptidase, S33 - - - 0.0002819 51.0
HKD2_k127_3908153_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007873 548.0
HKD2_k127_3908153_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002872 264.0
HKD2_k127_3932974_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.068e-311 973.0
HKD2_k127_3932974_1 Serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 359.0
HKD2_k127_3932974_2 NADH dehydrogenase K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 342.0
HKD2_k127_3932974_3 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 324.0
HKD2_k127_3932974_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03615,K05580 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000006241 218.0
HKD2_k127_3932974_5 PFAM EAL domain - - - 0.00000000000000000000000000000000000000000000000000003576 205.0
HKD2_k127_3932974_6 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000001599 197.0
HKD2_k127_3932974_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.000000000000000000000000000000000022 140.0
HKD2_k127_3932974_9 Transcriptional regulatory protein, C terminal - - - 0.0006291 42.0
HKD2_k127_3978215_0 Heat shock 70 kDa protein K04043 - - 1.478e-228 716.0
HKD2_k127_3978215_1 PFAM Peptidase M1 membrane alanine aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 631.0
HKD2_k127_3978215_10 ACT domain - - - 0.00000000000000000000000009 108.0
HKD2_k127_3978215_11 Sulfatase - - - 0.000000000000000000000178 113.0
HKD2_k127_3978215_12 Oxygen tolerance - - - 0.00000000000000009509 94.0
HKD2_k127_3978215_13 von Willebrand factor type A domain K07114 - - 0.000000000000002301 89.0
HKD2_k127_3978215_2 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 537.0
HKD2_k127_3978215_3 ATPase associated with various cellular K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 393.0
HKD2_k127_3978215_4 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 364.0
HKD2_k127_3978215_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 360.0
HKD2_k127_3978215_6 oxidoreductase activity K07114 - - 0.00000000000000000000000000000000000000000000000000000000003114 228.0
HKD2_k127_3978215_7 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000003762 195.0
HKD2_k127_3978215_8 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000000000000000003076 148.0
HKD2_k127_3978215_9 PFAM response regulator receiver K03413 - - 0.00000000000000000000000000000002804 129.0
HKD2_k127_3982584_0 glycosyl transferase K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 557.0
HKD2_k127_3982584_1 IMS family HHH motif K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 325.0
HKD2_k127_3982584_2 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008781 282.0
HKD2_k127_3982584_3 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000008126 227.0
HKD2_k127_3982584_5 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000009363 87.0
HKD2_k127_3983815_0 PFAM Metallophosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 355.0
HKD2_k127_3983815_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000117 261.0
HKD2_k127_3983815_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000009104 74.0
HKD2_k127_3991844_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 2.762e-239 762.0
HKD2_k127_3991844_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 6.699e-208 662.0
HKD2_k127_3991844_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 543.0
HKD2_k127_3991844_3 Belongs to the thiolase family K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 497.0
HKD2_k127_3991844_4 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000005889 211.0
HKD2_k127_3991844_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000001919 179.0
HKD2_k127_3991844_6 protein possibly involved in utilization of glycolate and propanediol - - - 0.000000000000000000000000000000000000000000003147 167.0
HKD2_k127_3991844_7 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000001903 168.0
HKD2_k127_3991844_8 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000001782 81.0
HKD2_k127_4033205_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 476.0
HKD2_k127_4033205_1 YgbB family K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000129 196.0
HKD2_k127_4033205_10 long-chain fatty acid transport protein - - - 0.00001174 56.0
HKD2_k127_4033205_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.00000000000000000000000000000000000000000000000000353 194.0
HKD2_k127_4033205_3 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000002105 186.0
HKD2_k127_4033205_4 - - - - 0.0000000000000000000000000000000000000000000000001091 183.0
HKD2_k127_4033205_5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.000000000000000000000000000000000000000000002063 172.0
HKD2_k127_4033205_6 Protein of unknown function, DUF481 - - - 0.0000000000000000000000000000000000000005596 163.0
HKD2_k127_4033205_7 Domain of unknown function (DUF4136) - - - 0.000000000000000000000000000003437 127.0
HKD2_k127_4033205_8 - - - - 0.00000000000000000000003571 104.0
HKD2_k127_4033205_9 - - - - 0.0000005826 51.0
HKD2_k127_4036472_0 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007493 449.0
HKD2_k127_4036472_1 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000001193 223.0
HKD2_k127_4036472_2 ABC transporter K02193 - 3.6.3.41 0.00000000000000000000000000000000000000001033 163.0
HKD2_k127_4036472_3 CcmB protein K02194 - - 0.0000000000000000000000000000000374 136.0
HKD2_k127_4036472_4 subunit of a heme lyase K02200 - - 0.0000000000000001406 87.0
HKD2_k127_4036472_6 iron ion homeostasis - - - 0.0007961 48.0
HKD2_k127_4075907_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 570.0
HKD2_k127_4075907_1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.000000000000000000000000000000000000000008335 164.0
HKD2_k127_4104305_0 Polysaccharide biosynthesis protein K15894 - 4.2.1.115 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 489.0
HKD2_k127_4104305_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 436.0
HKD2_k127_4104305_2 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008865 360.0
HKD2_k127_4104305_3 phosphorelay signal transduction system K01768,K10941,K11894 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009252 331.0
HKD2_k127_4104305_4 ABC transporter, ATP-binding protein K01990,K09691,K09693 - 3.6.3.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000158 278.0
HKD2_k127_4104305_5 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001253 262.0
HKD2_k127_4104305_6 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000006558 217.0
HKD2_k127_4104305_7 transport, permease protein K09690 - - 0.00000000000000000000000000000000000000000000000000000000007222 215.0
HKD2_k127_4104305_8 Pfam:UPF0118 - - - 0.00000000000000000000000000000000002411 149.0
HKD2_k127_4117062_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 535.0
HKD2_k127_4117062_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 535.0
HKD2_k127_4117062_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 316.0
HKD2_k127_4117062_3 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 286.0
HKD2_k127_4117062_4 YCII-related domain - - - 0.000000000000000000000000000000000000000007358 157.0
HKD2_k127_4117062_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000761 139.0
HKD2_k127_4117062_6 monooxygenase activity - - - 0.00000000000000000000000000007465 126.0
HKD2_k127_4117062_7 STAS domain - - - 0.0000003572 56.0
HKD2_k127_4132758_0 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 4.41e-226 713.0
HKD2_k127_4132758_1 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 559.0
HKD2_k127_4132758_2 conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 287.0
HKD2_k127_4132758_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891,K15546 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000001535 201.0
HKD2_k127_4132758_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000003564 166.0
HKD2_k127_4132758_5 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.000000000000000000000000001122 113.0
HKD2_k127_4132758_6 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000003787 63.0
HKD2_k127_4159081_0 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 415.0
HKD2_k127_4159081_1 PFAM Phenazine biosynthesis PhzC PhzF protein K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 331.0
HKD2_k127_4159081_2 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000002 210.0
HKD2_k127_4159446_0 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 414.0
HKD2_k127_4159446_1 CoA binding domain K06929 - - 0.000000000000000000000000000000000000001065 152.0
HKD2_k127_4159446_2 Large extracellular alpha-helical protein K06894 - - 0.0000000000000001002 90.0
HKD2_k127_417438_0 WD40-like Beta Propeller Repeat - - - 2.226e-269 852.0
HKD2_k127_417438_1 Histidine kinase A domain protein K07678 - 2.7.13.3 0.00000000000000000000000000000005996 139.0
HKD2_k127_4184177_1 Bacterial membrane protein YfhO - - - 0.00000000000000000000000009141 124.0
HKD2_k127_4184177_2 - - - - 0.000005756 55.0
HKD2_k127_4192244_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 480.0
HKD2_k127_4192244_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 380.0
HKD2_k127_4192244_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 369.0
HKD2_k127_4192244_3 Methyltransferase domain K00598 - 2.1.1.144 0.000000000000000000000000000000000000000000000000000336 188.0
HKD2_k127_4192244_4 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 0.000000000000000000000000000000000191 141.0
HKD2_k127_4192244_5 Two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.0000000000000000000000000000001839 139.0
HKD2_k127_4192244_6 Regulatory protein, FmdB - - - 0.00000000000000000003153 93.0
HKD2_k127_4200261_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.698e-199 634.0
HKD2_k127_4200261_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000008073 175.0
HKD2_k127_4200261_2 - - - - 0.000000000000000000000000000000000000000000000228 180.0
HKD2_k127_4200261_3 Glucose-6-phosphate dehydrogenase subunit - - - 0.0000000000000000000000000000000000000000001277 173.0
HKD2_k127_4200261_7 cellulose binding - - - 0.00005674 51.0
HKD2_k127_4214236_0 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 580.0
HKD2_k127_4214236_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 470.0
HKD2_k127_4214236_2 aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 357.0
HKD2_k127_4214236_3 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000000008945 244.0
HKD2_k127_4214236_4 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000513 218.0
HKD2_k127_4214236_5 heat shock protein binding K05516,K05801 - - 0.0000000000000000000000000000000000000546 156.0
HKD2_k127_4214236_6 phosphorelay signal transduction system - - - 0.000000000000000000000000000009584 129.0
HKD2_k127_4214236_7 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000001313 81.0
HKD2_k127_4220051_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 357.0
HKD2_k127_4220051_1 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 323.0
HKD2_k127_4220051_2 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000000000000000005191 188.0
HKD2_k127_4220051_3 Rhomboid family - - - 0.00000000000000000000000000000000000005372 152.0
HKD2_k127_4232847_0 AcrB/AcrD/AcrF family - - - 0.0 1223.0
HKD2_k127_4232847_1 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009506 454.0
HKD2_k127_4232847_2 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 340.0
HKD2_k127_4232847_3 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 306.0
HKD2_k127_4232847_4 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000006513 218.0
HKD2_k127_4232847_5 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000112 183.0
HKD2_k127_4232847_6 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.000000000000000000000000000004488 124.0
HKD2_k127_4232847_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000003313 106.0
HKD2_k127_4232847_8 Subtilase family - - - 0.0000000000003066 84.0
HKD2_k127_4232847_9 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000004763 59.0
HKD2_k127_4237497_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000694 145.0
HKD2_k127_4248358_0 YsiA-like protein, C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000001883 206.0
HKD2_k127_4248358_1 ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000001379 209.0
HKD2_k127_4248358_2 - - - - 0.000000000000000000000000000000000000000000000000000003441 196.0
HKD2_k127_4248358_3 Belongs to the heme-copper respiratory oxidase family - - - 0.000000000000000000000000000000000003103 148.0
HKD2_k127_4248358_4 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000006839 115.0
HKD2_k127_4248358_5 Vitamin k epoxide reductase - - - 0.000000000001022 80.0
HKD2_k127_4291137_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 5.317e-236 739.0
HKD2_k127_4291137_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.414e-232 727.0
HKD2_k127_4291137_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002406 279.0
HKD2_k127_4291137_3 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.00000000000000000000000007692 109.0
HKD2_k127_4291137_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000001864 104.0
HKD2_k127_4291137_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000003069 60.0
HKD2_k127_4291137_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000007687 54.0
HKD2_k127_4321216_0 PFAM Pyridoxal-dependent decarboxylase conserved domain K13745 - 4.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 507.0
HKD2_k127_4321216_1 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000001438 183.0
HKD2_k127_4321216_2 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000003845 124.0
HKD2_k127_4321216_3 Curli production assembly transport component CsgG - - - 0.000003167 60.0
HKD2_k127_4322217_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.275e-218 691.0
HKD2_k127_4322217_1 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 430.0
HKD2_k127_4322217_2 PFAM Nucleotidyl transferase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 308.0
HKD2_k127_4322217_3 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000228 223.0
HKD2_k127_4322217_4 Cobalamin B12-binding K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000002357 202.0
HKD2_k127_4322217_5 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000001956 183.0
HKD2_k127_4322217_6 Domain of unknown function (DUF4034) - - - 0.000000000000000000000000000000002644 144.0
HKD2_k127_4322217_7 TonB-dependent receptor - - - 0.00004063 56.0
HKD2_k127_4394896_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0 1196.0
HKD2_k127_4394896_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000004415 235.0
HKD2_k127_4394896_2 Spermine/spermidine synthase domain - - - 0.0000000000000000009374 99.0
HKD2_k127_4394896_3 Redoxin K03564 - 1.11.1.15 0.0000000000000001878 80.0
HKD2_k127_4408193_0 dipeptidyl-peptidase activity K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 408.0
HKD2_k127_4408193_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001592 260.0
HKD2_k127_4408193_2 - - - - 0.000000000000000000000000000000006777 142.0
HKD2_k127_4408193_3 Protein of unknown function (DUF1569) - - - 0.0000000000000000000000000000000226 130.0
HKD2_k127_4408193_4 - - - - 0.000000000000000000000000000006293 129.0
HKD2_k127_4408193_5 - - - - 0.000000000000000000000000001051 115.0
HKD2_k127_4408193_6 Dystroglycan-type cadherin-like domains. - - - 0.00000000000002266 84.0
HKD2_k127_4408193_7 photosynthesis K02453,K20543 - - 0.00000005879 59.0
HKD2_k127_441233_0 aldehyde-lyase activity K01621 - 4.1.2.22,4.1.2.9 0.0 1414.0
HKD2_k127_441233_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 404.0
HKD2_k127_441233_2 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000000000001421 202.0
HKD2_k127_441233_3 - - - - 0.000000000000000000000000000000000000000000006412 177.0
HKD2_k127_441233_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000003053 171.0
HKD2_k127_4414983_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009914 304.0
HKD2_k127_4414983_1 - K19693 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003492 281.0
HKD2_k127_4414983_2 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000003623 198.0
HKD2_k127_4414983_3 Vault protein inter-alpha-trypsin domain K07114 - - 0.000000000000000000000000000000000000000000000001734 183.0
HKD2_k127_4414983_4 Peptidase family M28 - - - 0.00000008543 63.0
HKD2_k127_4425132_0 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 391.0
HKD2_k127_4425132_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 376.0
HKD2_k127_4425132_2 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000002824 227.0
HKD2_k127_4443698_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 503.0
HKD2_k127_4443698_1 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 446.0
HKD2_k127_4443698_10 DinB superfamily - - - 0.0000000000000000000001966 103.0
HKD2_k127_4443698_11 SnoaL-like domain - - - 0.0000000006782 65.0
HKD2_k127_4443698_12 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00001355 48.0
HKD2_k127_4443698_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 442.0
HKD2_k127_4443698_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 317.0
HKD2_k127_4443698_4 May be involved in recombinational repair of damaged DNA K03631,K13582 GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 341.0
HKD2_k127_4443698_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001177 308.0
HKD2_k127_4443698_6 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000004382 201.0
HKD2_k127_4443698_7 Domain of unknown function (DUF4261) - - - 0.00000000000000000000000000000000000000000000000002751 189.0
HKD2_k127_4443698_8 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000501 162.0
HKD2_k127_4443698_9 histidine kinase - - - 0.0000000000000000000000000000008405 133.0
HKD2_k127_4469511_0 Prokaryotic cytochrome b561 - - - 1.324e-247 783.0
HKD2_k127_4469511_1 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 345.0
HKD2_k127_4469511_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 330.0
HKD2_k127_4469511_3 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006788 274.0
HKD2_k127_4469511_4 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000003441 261.0
HKD2_k127_4469511_5 Gamma-glutamyl-gamma-aminobutyrate hydrolase K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000003453 236.0
HKD2_k127_4469511_6 Dodecin K09165 - - 0.00000000000000001638 84.0
HKD2_k127_4469511_7 negative regulation of transcription, DNA-templated - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000003851 60.0
HKD2_k127_448429_0 ompA family - - - 0.00002711 59.0
HKD2_k127_4486590_0 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 379.0
HKD2_k127_4486590_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000005269 210.0
HKD2_k127_4492974_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 530.0
HKD2_k127_4492974_1 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 357.0
HKD2_k127_4492974_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 357.0
HKD2_k127_4492974_3 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 347.0
HKD2_k127_4492974_4 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 339.0
HKD2_k127_4492974_5 Fis family transcriptional regulator K03413 - - 0.000000001074 62.0
HKD2_k127_4492974_6 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000002074 66.0
HKD2_k127_44932_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000005601 231.0
HKD2_k127_44932_1 lipolytic protein G-D-S-L family K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.000000000000000000000000000000000000000000000000001585 190.0
HKD2_k127_44932_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000006057 176.0
HKD2_k127_44932_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000001034 114.0
HKD2_k127_4504334_0 Phosphohydrolase-associated domain K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 401.0
HKD2_k127_4504334_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009841 376.0
HKD2_k127_4504334_2 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008557 278.0
HKD2_k127_4504334_3 Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000005295 196.0
HKD2_k127_4504334_4 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000000000000001985 172.0
HKD2_k127_4516662_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1506.0
HKD2_k127_4516662_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005277 431.0
HKD2_k127_4516662_2 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000007854 247.0
HKD2_k127_4516662_3 COG1538 Outer membrane protein K18139 - - 0.0000000000000000000000007581 109.0
HKD2_k127_4516662_4 - - - - 0.000000000000358 78.0
HKD2_k127_4532175_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 598.0
HKD2_k127_4532175_1 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 338.0
HKD2_k127_4532175_10 Uncharacterized ACR, COG1399 K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000008651 113.0
HKD2_k127_4532175_11 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000002835 100.0
HKD2_k127_4532175_12 - - - - 0.000000000000000000003713 107.0
HKD2_k127_4532175_13 Ribosomal L32p protein family K02911 - - 0.00000000000000000006047 90.0
HKD2_k127_4532175_14 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000007004 55.0
HKD2_k127_4532175_15 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.000001418 59.0
HKD2_k127_4532175_2 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 355.0
HKD2_k127_4532175_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621,K21576,K21577 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 312.0
HKD2_k127_4532175_4 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002084 289.0
HKD2_k127_4532175_5 PFAM Short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000339 275.0
HKD2_k127_4532175_6 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002207 302.0
HKD2_k127_4532175_7 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000003038 241.0
HKD2_k127_4532175_8 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000001734 124.0
HKD2_k127_4532175_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000004844 109.0
HKD2_k127_453695_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 461.0
HKD2_k127_453695_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 465.0
HKD2_k127_453695_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 439.0
HKD2_k127_453695_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 321.0
HKD2_k127_453695_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008843 269.0
HKD2_k127_453695_5 peroxiredoxin activity K00627,K01607 - 2.3.1.12,4.1.1.44 0.000000000000000000000000000000000000000000000000001422 186.0
HKD2_k127_453695_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859,K07566 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,2.7.7.87 0.0000000000000000000000000000000000000000000001277 175.0
HKD2_k127_453695_7 Tyrosine phosphatase family - - - 0.0000000000000003322 85.0
HKD2_k127_453695_8 Preprotein translocase subunit K03210 - - 0.000000000001126 72.0
HKD2_k127_453695_9 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.000003684 59.0
HKD2_k127_456678_0 Phosphate acyltransferases K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 518.0
HKD2_k127_456678_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 421.0
HKD2_k127_456678_2 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.00000000000000000000000003144 121.0
HKD2_k127_4573173_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 1.419e-229 730.0
HKD2_k127_4573173_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.54e-197 630.0
HKD2_k127_4573173_2 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000875 585.0
HKD2_k127_4573173_3 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000001309 196.0
HKD2_k127_4573173_4 arylsulfatase activity - - - 0.0000000000000000000000000000001138 143.0
HKD2_k127_4573173_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000002108 118.0
HKD2_k127_4573173_6 PFAM PilZ domain - - - 0.0006682 47.0
HKD2_k127_4626511_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214,K01534 - 3.2.1.68,3.6.3.3,3.6.3.5 1.6e-242 773.0
HKD2_k127_4626511_1 PFAM Peptidase M16 inactive domain K07263 - - 1.454e-227 734.0
HKD2_k127_4626511_10 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 345.0
HKD2_k127_4626511_11 Belongs to the cysteine synthase cystathionine beta- synthase family K01738,K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 307.0
HKD2_k127_4626511_12 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002399 280.0
HKD2_k127_4626511_13 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004617 276.0
HKD2_k127_4626511_14 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008406 247.0
HKD2_k127_4626511_15 Abc transporter K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000001139 247.0
HKD2_k127_4626511_16 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000003586 237.0
HKD2_k127_4626511_17 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000000000000000000000000000000184 214.0
HKD2_k127_4626511_18 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000184 214.0
HKD2_k127_4626511_19 carboxypeptidase activity K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000002463 217.0
HKD2_k127_4626511_2 Nickel-dependent hydrogenase - - - 1.886e-195 620.0
HKD2_k127_4626511_20 peroxiredoxin activity K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000003573 211.0
HKD2_k127_4626511_21 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000002298 210.0
HKD2_k127_4626511_22 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000004382 201.0
HKD2_k127_4626511_23 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000003091 198.0
HKD2_k127_4626511_24 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000001538 211.0
HKD2_k127_4626511_25 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000003658 192.0
HKD2_k127_4626511_26 Oxidoreductase NAD-binding domain K02823 - - 0.000000000000000000000000000000000000000000000001527 183.0
HKD2_k127_4626511_27 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000000001097 165.0
HKD2_k127_4626511_28 of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000002762 145.0
HKD2_k127_4626511_29 response to oxidative stress K04063 - - 0.0000000000000000000000000000000005128 136.0
HKD2_k127_4626511_3 PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain K02472,K13015 - 1.1.1.136,1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 514.0
HKD2_k127_4626511_30 Thioredoxin domain - - - 0.0000000000000000000000002923 111.0
HKD2_k127_4626511_31 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000001782 113.0
HKD2_k127_4626511_32 integral membrane protein - - - 0.00000000000000000000003172 112.0
HKD2_k127_4626511_33 Hydrogenase maturation protease - - - 0.00000000000000000001341 101.0
HKD2_k127_4626511_34 TIGRFAM Glutaredoxin-like domain protein - - - 0.000000000000000005425 85.0
HKD2_k127_4626511_35 zinc-ribbon domain - - - 0.0000000005937 68.0
HKD2_k127_4626511_36 Protein of unknown function DUF45 K07043 - - 0.0000001187 61.0
HKD2_k127_4626511_4 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008551 456.0
HKD2_k127_4626511_5 coenzyme F420 hydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 430.0
HKD2_k127_4626511_6 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 410.0
HKD2_k127_4626511_7 PFAM NAD-dependent epimerase dehydratase K01784,K02473 - 5.1.3.2,5.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 362.0
HKD2_k127_4626511_8 Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 357.0
HKD2_k127_4626511_9 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 342.0
HKD2_k127_4636552_0 Molydopterin dinucleotide binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 601.0
HKD2_k127_4636552_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009569 250.0
HKD2_k127_4636552_2 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000111 215.0
HKD2_k127_4636552_3 PFAM CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000006366 150.0
HKD2_k127_4639620_0 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 516.0
HKD2_k127_4639620_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 433.0
HKD2_k127_4639620_10 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 296.0
HKD2_k127_4639620_11 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 287.0
HKD2_k127_4639620_12 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002552 278.0
HKD2_k127_4639620_13 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001722 273.0
HKD2_k127_4639620_14 Abc transporter K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000001821 252.0
HKD2_k127_4639620_15 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000000000000000008431 242.0
HKD2_k127_4639620_16 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000004395 203.0
HKD2_k127_4639620_17 Cytochrome b(N-terminal)/b6/petB K00412,K02635,K02637,K03887,K03891,K15879 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 - 0.00000000000000000000000000000000000000000000000001173 195.0
HKD2_k127_4639620_18 O-Antigen ligase - - - 0.0000000000000000000000000000000000000000000000001807 196.0
HKD2_k127_4639620_19 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.0000000000000000000000000000000000000000000000008973 178.0
HKD2_k127_4639620_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 434.0
HKD2_k127_4639620_20 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000000000000000000000006189 175.0
HKD2_k127_4639620_21 General secretory system II protein E domain protein - - - 0.0000000000000000000000000000000000000000004645 165.0
HKD2_k127_4639620_22 RNA recognition motif - - - 0.0000000000000000000000006911 108.0
HKD2_k127_4639620_23 PFAM Protein-tyrosine phosphatase, low molecular weight K01104,K20201 - 3.1.3.48,3.9.1.2 0.0000000000000000001865 94.0
HKD2_k127_4639620_24 oxidoreductase activity, acting on diphenols and related substances as donors K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.000000000000000003482 93.0
HKD2_k127_4639620_25 Response regulator, receiver - - - 0.0000000001521 71.0
HKD2_k127_4639620_26 Tetratricopeptide repeat - - - 0.0001753 54.0
HKD2_k127_4639620_27 mitochondrial gene expression K02935 - - 0.0002682 51.0
HKD2_k127_4639620_3 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 408.0
HKD2_k127_4639620_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 396.0
HKD2_k127_4639620_5 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 385.0
HKD2_k127_4639620_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 381.0
HKD2_k127_4639620_7 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 353.0
HKD2_k127_4639620_8 denitrification pathway K02569,K15876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 348.0
HKD2_k127_4639620_9 Cytochrome c554 and c-prime K03620 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 347.0
HKD2_k127_4657585_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 493.0
HKD2_k127_4657585_1 Amino-transferase class IV K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 439.0
HKD2_k127_4657585_2 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008724 264.0
HKD2_k127_4657585_3 ATP-dependent DNA helicase activity K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.00001617 50.0
HKD2_k127_4678655_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 3.176e-219 695.0
HKD2_k127_4678655_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 588.0
HKD2_k127_4678655_10 PIN domain - - - 0.0000000000000000000000000000000001078 137.0
HKD2_k127_4678655_11 - - - - 0.000000000000000000000000841 107.0
HKD2_k127_4678655_12 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.0000000000000000001694 90.0
HKD2_k127_4678655_15 PFAM O-methyltransferase - - - 0.00000000006714 64.0
HKD2_k127_4678655_16 Type II secretion system K02653 - - 0.00001374 57.0
HKD2_k127_4678655_17 Domain of unknown function (DUF4386) - - - 0.00001543 51.0
HKD2_k127_4678655_2 PFAM Enoyl-CoA hydratase isomerase K11264 - 4.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 348.0
HKD2_k127_4678655_3 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 320.0
HKD2_k127_4678655_4 PFAM Enoyl-CoA hydratase isomerase K11264 - 4.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 299.0
HKD2_k127_4678655_5 region 4 type 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004717 263.0
HKD2_k127_4678655_6 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 0.0000000000000000000000000000000000000000000000000000000000000000004516 241.0
HKD2_k127_4678655_7 - - - - 0.000000000000000000000000000000000000000000001526 171.0
HKD2_k127_4678655_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000000000000000000007068 163.0
HKD2_k127_4678655_9 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000001353 154.0
HKD2_k127_4712854_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 527.0
HKD2_k127_4712854_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006151 379.0
HKD2_k127_4712854_2 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000008087 220.0
HKD2_k127_4712854_3 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000004488 205.0
HKD2_k127_4712854_4 TIGR00255 family - - - 0.00000000000000000000000000000000000000000000000000000005211 206.0
HKD2_k127_4712854_5 Belongs to the UPF0296 family K09777 - - 0.000000000000000000000002283 105.0
HKD2_k127_4712854_6 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.00000000000000000455 90.0
HKD2_k127_4712854_7 Tetratricopeptide repeat - - - 0.0000000001723 72.0
HKD2_k127_4712854_8 RNA polymerase Rpb6 K03060 - 2.7.7.6 0.00000004452 57.0
HKD2_k127_4714362_0 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 559.0
HKD2_k127_4714362_1 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000002809 207.0
HKD2_k127_4714362_2 AAA domain - - - 0.00000000000000000000000000000000000000000000008352 173.0
HKD2_k127_4715212_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000001127 220.0
HKD2_k127_4715212_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - 0.0000000000000000000000000005109 117.0
HKD2_k127_4726700_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 542.0
HKD2_k127_4726700_1 Amino acid permease K20265 - - 0.00000000000000000000000000000000000000000000000000000000000000000004613 244.0
HKD2_k127_4752924_0 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 395.0
HKD2_k127_4752924_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000006257 154.0
HKD2_k127_4752924_2 Belongs to the UPF0354 family - - - 0.000000000000003134 85.0
HKD2_k127_4752924_3 Right handed beta helix region - - - 0.000000000000005837 90.0
HKD2_k127_4752924_4 PKD domain - - - 0.000001071 63.0
HKD2_k127_4752924_5 cellulose binding K01406 - 3.4.24.40 0.00005076 57.0
HKD2_k127_4763779_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 574.0
HKD2_k127_4763779_1 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 421.0
HKD2_k127_4763779_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 396.0
HKD2_k127_4763779_3 DinB family - - - 0.0000000000000001035 86.0
HKD2_k127_4782051_0 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 384.0
HKD2_k127_4782051_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001851 271.0
HKD2_k127_4782051_10 DUF167 K09131 - - 0.0000000000002594 76.0
HKD2_k127_4782051_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000002429 216.0
HKD2_k127_4782051_3 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000003245 197.0
HKD2_k127_4782051_4 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000001516 195.0
HKD2_k127_4782051_5 DNA polymerase III, delta' K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000002888 199.0
HKD2_k127_4782051_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000005158 145.0
HKD2_k127_4782051_7 PFAM Formiminotransferase-cyclodeaminase - - - 0.000000000000000000000000000000009275 136.0
HKD2_k127_4782051_8 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000001387 131.0
HKD2_k127_4782051_9 DivIVA protein K04074 - - 0.0000000000000000004601 93.0
HKD2_k127_4787258_0 Glycosyltransferase like family 2 K07011,K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 329.0
HKD2_k127_4787258_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009714 262.0
HKD2_k127_4787258_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000005902 245.0
HKD2_k127_4787258_3 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000006575 203.0
HKD2_k127_4787258_4 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000001162 196.0
HKD2_k127_4787258_5 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000000000000000000001735 98.0
HKD2_k127_4787258_6 Glycosyltransferase like family 2 - - - 0.000000000005501 77.0
HKD2_k127_4819952_0 Belongs to the DEAD box helicase family K03732,K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 569.0
HKD2_k127_4819952_1 COG0666 FOG Ankyrin repeat K06867 - - 0.0000000000000000000001364 102.0
HKD2_k127_4819952_2 Ankyrin repeats (many copies) K06867,K21440 - - 0.00000000993 61.0
HKD2_k127_4836823_0 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 465.0
HKD2_k127_4836823_1 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001046 274.0
HKD2_k127_4836823_2 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000003695 119.0
HKD2_k127_4836823_3 DNA topoisomerase III K03169 - 5.99.1.2 0.00000000000000000000000000008182 120.0
HKD2_k127_4836823_4 ACT domain - - - 0.000000000000000000000000001244 118.0
HKD2_k127_4836935_0 ABC transporter K06147,K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 576.0
HKD2_k127_4836935_1 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 577.0
HKD2_k127_4836935_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 505.0
HKD2_k127_4836935_3 transferase activity, transferring glycosyl groups K00754 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 290.0
HKD2_k127_4836935_4 COG1670 Acetyltransferases, including N-acetylases of - - - 0.000000000000000000000000000000000000008559 154.0
HKD2_k127_4842005_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1037.0
HKD2_k127_4842005_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 567.0
HKD2_k127_4842005_10 PFAM methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001963 282.0
HKD2_k127_4842005_11 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001831 281.0
HKD2_k127_4842005_12 helix_turn_helix, mercury resistance K22491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007372 261.0
HKD2_k127_4842005_13 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001114 256.0
HKD2_k127_4842005_14 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000001322 233.0
HKD2_k127_4842005_15 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811,K09812 GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531 - 0.000000000000000000000000000000000000000000000000168 188.0
HKD2_k127_4842005_16 EVE domain - - - 0.000000000000000000000000000000000000000000006766 166.0
HKD2_k127_4842005_17 PFAM response regulator receiver, regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000002952 171.0
HKD2_k127_4842005_18 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.0000000000000000000000000000000000000006153 158.0
HKD2_k127_4842005_19 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000000003132 147.0
HKD2_k127_4842005_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005571 549.0
HKD2_k127_4842005_20 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.00000000000000000000000000000000000001852 161.0
HKD2_k127_4842005_21 COGs COG3093 Plasmid maintenance system antidote protein K21498 - - 0.00000000000000000000000000000000000004758 144.0
HKD2_k127_4842005_22 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000001761 101.0
HKD2_k127_4842005_23 - - - - 0.0000000000000000008333 93.0
HKD2_k127_4842005_24 Mycolic acid cyclopropane synthetase - - - 0.00000000305 68.0
HKD2_k127_4842005_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008185 520.0
HKD2_k127_4842005_4 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 518.0
HKD2_k127_4842005_5 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 402.0
HKD2_k127_4842005_6 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009859 391.0
HKD2_k127_4842005_7 Transport permease protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 385.0
HKD2_k127_4842005_8 von willebrand factor, type A K11912 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 301.0
HKD2_k127_4842005_9 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 288.0
HKD2_k127_4879518_0 Domain of unknown function (DUF5122) beta-propeller K14274,K20276,K21449 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 498.0
HKD2_k127_4879518_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000002666 263.0
HKD2_k127_4879518_2 membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001371 250.0
HKD2_k127_4879518_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000001345 153.0
HKD2_k127_4879518_4 Putative Ig domain - - - 0.0000000000000000001628 105.0
HKD2_k127_4879518_5 TIGRFAM Competence protein ComEA, helix-hairpin-helix K02237 - - 0.000000000000000006533 87.0
HKD2_k127_4900317_1 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0009065 44.0
HKD2_k127_4908378_0 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 304.0
HKD2_k127_4908378_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006214 287.0
HKD2_k127_4908378_10 - - - - 0.00006907 55.0
HKD2_k127_4908378_11 GMP synthase-glutamine amidotransferase - - - 0.0001139 54.0
HKD2_k127_4908378_2 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000003674 248.0
HKD2_k127_4908378_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007331 251.0
HKD2_k127_4908378_4 - - - - 0.0000000000000000000000000000000000000000000000000000000155 214.0
HKD2_k127_4908378_5 oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor K06282 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.12.99.6 0.00000000000000000000000000000000000000000003231 163.0
HKD2_k127_4908378_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000002457 162.0
HKD2_k127_4908378_7 fatty acid desaturase - - - 0.0000000000000008458 90.0
HKD2_k127_4908378_9 Cysteine-rich secretory protein family - - - 0.0000000000003949 78.0
HKD2_k127_494535_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 562.0
HKD2_k127_494535_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 532.0
HKD2_k127_494535_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007417 271.0
HKD2_k127_494535_3 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000231 241.0
HKD2_k127_494535_5 Belongs to the UPF0403 family - - - 0.00000000000000000000000000000000000000000000000000000000107 207.0
HKD2_k127_494535_6 PAAR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000001251 200.0
HKD2_k127_494535_7 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000002045 141.0
HKD2_k127_494535_8 - - - - 0.000000000000000000000000004393 115.0
HKD2_k127_4994570_0 Domain of unknown function (DUF5117) - - - 1.016e-305 957.0
HKD2_k127_4994570_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 8.734e-205 642.0
HKD2_k127_4994570_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000008115 217.0
HKD2_k127_4994570_3 DinB family - - - 0.000000000000000000001314 100.0
HKD2_k127_4994570_4 - - - - 0.000000000000000001024 92.0
HKD2_k127_4994570_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000006258 87.0
HKD2_k127_4994570_6 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000002609 87.0
HKD2_k127_4994570_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000001815 84.0
HKD2_k127_5011102_0 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 370.0
HKD2_k127_5011102_1 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007618 290.0
HKD2_k127_5011102_2 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002185 276.0
HKD2_k127_5011102_3 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000002444 112.0
HKD2_k127_5011102_4 Biotin-lipoyl like - - - 0.0000000000000000003897 96.0
HKD2_k127_5021205_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 417.0
HKD2_k127_5021205_1 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 321.0
HKD2_k127_5021205_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005553 283.0
HKD2_k127_5021205_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000000000000000000000000000000000000000000002842 226.0
HKD2_k127_5021205_4 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000004194 155.0
HKD2_k127_5021205_5 regulation of DNA-templated transcription, elongation - - - 0.00000000000008377 78.0
HKD2_k127_5047288_0 Acetyl-coenzyme A transporter 1 K08218 - - 2.864e-197 627.0
HKD2_k127_5047288_1 PFAM Type II secretion system protein E K02454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000716 568.0
HKD2_k127_5047288_2 serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000003058 141.0
HKD2_k127_5047288_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000003309 133.0
HKD2_k127_5047288_4 Peptidase M48 - - - 0.0000000000000000000000542 115.0
HKD2_k127_5047648_0 associated with various cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 391.0
HKD2_k127_5047648_1 membrane organization K07277,K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 438.0
HKD2_k127_5047648_2 - - - - 0.000000000000000000000000000000000000000000000000000003825 203.0
HKD2_k127_5047648_3 Tetratricopeptide repeat - - - 0.0000000000004774 78.0
HKD2_k127_5047648_4 lyase activity - - - 0.0000000001868 74.0
HKD2_k127_5067818_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1354.0
HKD2_k127_5067818_1 COGs COG0471 Di- and tricarboxylate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 413.0
HKD2_k127_5067818_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 328.0
HKD2_k127_5067818_3 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 281.0
HKD2_k127_5067818_4 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000004582 161.0
HKD2_k127_5076251_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 522.0
HKD2_k127_5076251_1 Polysaccharide biosynthesis protein K17947 - 5.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 432.0
HKD2_k127_5076251_2 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 344.0
HKD2_k127_5076251_3 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 329.0
HKD2_k127_5076251_4 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001265 282.0
HKD2_k127_5076251_5 O-Antigen ligase K18814 - - 0.0000000000000000000000000000000000000000000001012 184.0
HKD2_k127_5076251_6 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000002678 156.0
HKD2_k127_5076251_7 Rieske [2Fe-2S] domain K03886 - - 0.00000000000000000000000005046 113.0
HKD2_k127_5076251_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000001181 111.0
HKD2_k127_5076251_9 Trm112p-like protein K09791 - - 0.0000000000000000003111 88.0
HKD2_k127_5091040_0 Aspartate-ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 589.0
HKD2_k127_5091040_1 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 473.0
HKD2_k127_5091040_2 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 399.0
HKD2_k127_5091040_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004963 272.0
HKD2_k127_5091040_4 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000001421 198.0
HKD2_k127_5091040_5 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.00000000000000000000000005556 125.0
HKD2_k127_5091040_6 Belongs to the peptidase S8 family - - - 0.00000000000000004236 97.0
HKD2_k127_511345_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 3.973e-203 654.0
HKD2_k127_511345_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 491.0
HKD2_k127_511345_2 Inward rectifier potassium channel K08715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 293.0
HKD2_k127_511345_3 Cytochrome c K02305 - - 0.00000000000000000000000000000000000000000000000000000005017 218.0
HKD2_k127_511345_4 - - - - 0.000000000000000000000000000000000000001497 151.0
HKD2_k127_511345_5 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000000002591 124.0
HKD2_k127_511345_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.00000003515 66.0
HKD2_k127_511345_8 - - - - 0.00000006778 64.0
HKD2_k127_5139375_0 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.051e-316 980.0
HKD2_k127_5139375_1 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 439.0
HKD2_k127_5139375_10 Peptidase M50B-like - - - 0.000000000000000000000000000000000000000000000221 175.0
HKD2_k127_5139375_11 Ankyrin repeat K15502,K15503,K15504 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006810,GO:0006888,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016050,GO:0016192,GO:0022607,GO:0031974,GO:0031981,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0061024,GO:0065003,GO:0070013,GO:0071840,GO:0090114 - 0.0000000000000000000000000001002 129.0
HKD2_k127_5139375_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000004459 80.0
HKD2_k127_5139375_13 Protein of unknown function (DUF2628) - - - 0.0000000052 65.0
HKD2_k127_5139375_15 - - - - 0.0002558 53.0
HKD2_k127_5139375_2 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 404.0
HKD2_k127_5139375_3 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 373.0
HKD2_k127_5139375_4 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 351.0
HKD2_k127_5139375_5 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 333.0
HKD2_k127_5139375_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 301.0
HKD2_k127_5139375_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009435 296.0
HKD2_k127_5139375_8 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007903 290.0
HKD2_k127_5139375_9 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000008089 228.0
HKD2_k127_5152471_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 542.0
HKD2_k127_5152471_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 357.0
HKD2_k127_5152471_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000006176 188.0
HKD2_k127_5152471_3 - - - - 0.000000000000000000000000000000000002881 153.0
HKD2_k127_5152471_4 cellulose binding - - - 0.000000000000000000000000000001458 139.0
HKD2_k127_5152471_6 Tetratricopeptide repeat - - - 0.000003302 57.0
HKD2_k127_5152471_7 - - - - 0.00001012 57.0
HKD2_k127_51561_0 PA domain K14647 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 571.0
HKD2_k127_51561_1 sequence-specific DNA binding K03719,K05800 GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000001279 164.0
HKD2_k127_51561_2 MarC family integral membrane protein - - - 0.00000000000000000000000000000000004041 141.0
HKD2_k127_5161109_0 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 528.0
HKD2_k127_5161109_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 478.0
HKD2_k127_5161109_10 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000002928 205.0
HKD2_k127_5161109_11 cyclase family K07130 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000005097 199.0
HKD2_k127_5161109_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000005194 176.0
HKD2_k127_5161109_13 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000001255 160.0
HKD2_k127_5161109_14 PFAM Transcription termination factor nusG K05785 - - 0.00000000000000000000000000000000000001219 150.0
HKD2_k127_5161109_15 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.000000000000000000000000002366 114.0
HKD2_k127_5161109_16 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.00000000000000000002585 92.0
HKD2_k127_5161109_17 Putative addiction module component - - - 0.000000000000004472 77.0
HKD2_k127_5161109_18 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000001088 74.0
HKD2_k127_5161109_19 ABC transporter - GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006869,GO:0008150,GO:0009507,GO:0009536,GO:0010876,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033036,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0071702 - 0.000000003056 60.0
HKD2_k127_5161109_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 434.0
HKD2_k127_5161109_3 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 430.0
HKD2_k127_5161109_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 388.0
HKD2_k127_5161109_5 Bacterial extracellular solute-binding protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 304.0
HKD2_k127_5161109_6 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003809 258.0
HKD2_k127_5161109_7 metallopeptidase activity K01179,K20276 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000642 237.0
HKD2_k127_5161109_8 geranylgeranyl reductase activity K06444,K17830 - 1.3.1.101,1.3.7.11,5.5.1.18 0.0000000000000000000000000000000000000000000000000000000000001982 227.0
HKD2_k127_5161109_9 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000253 216.0
HKD2_k127_5170592_0 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000005202 211.0
HKD2_k127_5170592_1 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000002966 209.0
HKD2_k127_5170592_2 Carboxypeptidase regulatory-like domain - - - 0.000003817 60.0
HKD2_k127_5191847_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 584.0
HKD2_k127_5197178_0 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.0 1039.0
HKD2_k127_5197178_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 589.0
HKD2_k127_5197178_2 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009317 512.0
HKD2_k127_5197178_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 460.0
HKD2_k127_5197178_4 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.00000000000000000000000000004497 129.0
HKD2_k127_5197178_5 Amino acid permease K20265 - - 0.00000000000000001433 85.0
HKD2_k127_5197178_6 - - - - 0.0000000002855 64.0
HKD2_k127_521410_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 322.0
HKD2_k127_521410_1 protein kinase activity - - - 0.000000000000000000000000000000000000000000000001037 199.0
HKD2_k127_521410_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000144 153.0
HKD2_k127_521410_3 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000289 133.0
HKD2_k127_5242799_0 cAMP biosynthetic process K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 383.0
HKD2_k127_5242799_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003868 266.0
HKD2_k127_5242799_2 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008255 263.0
HKD2_k127_5242799_3 Elongation factor P K02356 - - 0.00000000000000000000000000000000000000000000000000009204 191.0
HKD2_k127_5242799_4 - - - - 0.000000000000000001324 94.0
HKD2_k127_5264338_0 cellulase activity - - - 7.985e-267 876.0
HKD2_k127_5264338_1 FAD linked oxidase - - - 7.805e-227 709.0
HKD2_k127_5264338_10 Autotransporter beta-domain - - - 0.00000000001749 79.0
HKD2_k127_5264338_2 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 510.0
HKD2_k127_5264338_3 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 476.0
HKD2_k127_5264338_4 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 296.0
HKD2_k127_5264338_6 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001676 237.0
HKD2_k127_5264338_7 ethyl tert-butyl ether degradation - - - 0.000000000000000000000000000000698 124.0
HKD2_k127_5264338_8 endonuclease I - - - 0.000000000000000000000000001321 132.0
HKD2_k127_5264338_9 Belongs to the peptidase S8 family K13276,K17734 - - 0.00000000001329 79.0
HKD2_k127_5264780_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001374 285.0
HKD2_k127_5264780_1 benzoyl-CoA reductase K04113 - 1.3.7.8 0.000000000000000000000000000000007516 136.0
HKD2_k127_5264780_2 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000002918 124.0
HKD2_k127_5273703_0 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 340.0
HKD2_k127_5273703_1 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K03148,K21029 - 2.7.7.73,2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 318.0
HKD2_k127_5273703_2 3-Deoxy-D-manno-octulosonic-acid transferase K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000009115 264.0
HKD2_k127_5273703_3 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000243 250.0
HKD2_k127_5273703_4 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002597 261.0
HKD2_k127_5273703_5 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000001513 202.0
HKD2_k127_5273703_6 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000002824 195.0
HKD2_k127_5273703_7 D,D-heptose 1,7-bisphosphate phosphatase K01089,K01929,K02843,K03273 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033692,GO:0034200,GO:0034637,GO:0034645,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046872,GO:0046914,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19,6.3.2.10 0.00000000000000000000000000000000000000007831 160.0
HKD2_k127_5273703_8 TIGRFAM Translation elongation factor K02355 - - 0.00000000002351 68.0
HKD2_k127_5273703_9 Evidence 4 Homologs of previously reported genes of - - - 0.000000003145 63.0
HKD2_k127_5284863_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 476.0
HKD2_k127_5284863_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 346.0
HKD2_k127_5284863_2 ParB-like nuclease domain - - - 0.0000000000000000000000001101 111.0
HKD2_k127_5294805_0 DEAD DEAH box K03724 - - 0.0 1630.0
HKD2_k127_5294805_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 604.0
HKD2_k127_5294805_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 350.0
HKD2_k127_5294805_3 Belongs to the FPG family K05522 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000008016 219.0
HKD2_k127_5294805_4 peptidyl-tyrosine sulfation - - - 0.0000000000759 73.0
HKD2_k127_5304787_0 Amino acid permease - - - 2.257e-204 656.0
HKD2_k127_5304787_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179,K08941 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 553.0
HKD2_k127_5304787_2 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 339.0
HKD2_k127_5304787_3 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 330.0
HKD2_k127_5304787_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003232 262.0
HKD2_k127_5304787_5 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000005415 249.0
HKD2_k127_5304787_6 Pyruvate ferredoxin/flavodoxin oxidoreductase K00179,K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000005784 201.0
HKD2_k127_5304787_7 - - - - 0.000000000000000000000000001205 117.0
HKD2_k127_5388371_0 Phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006828 606.0
HKD2_k127_5388371_1 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009924 565.0
HKD2_k127_5388371_2 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 340.0
HKD2_k127_5400378_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 311.0
HKD2_k127_5400378_1 oxidoreductase activity - - - 0.0000002326 55.0
HKD2_k127_5400378_2 COGs COG2380 conserved - - - 0.000002393 58.0
HKD2_k127_5403954_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 446.0
HKD2_k127_5403954_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 327.0
HKD2_k127_5403954_2 PKD domain - - - 0.00000000000002027 77.0
HKD2_k127_5403954_3 transmembrane transporter activity - - - 0.0008002 42.0
HKD2_k127_5412143_0 Belongs to the peptidase S16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000003267 233.0
HKD2_k127_5412143_1 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000769 162.0
HKD2_k127_5412143_2 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000003889 159.0
HKD2_k127_5412143_3 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000000000000000000156 136.0
HKD2_k127_5412143_4 transcriptional regulator - - - 0.0000000000000000000000000000000002567 143.0
HKD2_k127_5412143_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000007214 121.0
HKD2_k127_5412143_6 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000001666 108.0
HKD2_k127_5412143_7 Putative zinc-finger - - - 0.000000001019 69.0
HKD2_k127_5412143_9 Putative zinc-finger - - - 0.00001032 57.0
HKD2_k127_5417182_0 Beta-eliminating lyase K01667 - 4.1.99.1 6.481e-223 699.0
HKD2_k127_5417182_1 PFAM Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 484.0
HKD2_k127_5417182_2 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008648 335.0
HKD2_k127_5417182_3 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001834 289.0
HKD2_k127_5417182_4 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000000000323 211.0
HKD2_k127_5417182_5 von Willebrand factor, type A K07114 - - 0.00000000000000000004899 102.0
HKD2_k127_5417182_6 - - - - 0.0000001242 63.0
HKD2_k127_5425255_0 helicase activity - - - 2.796e-320 999.0
HKD2_k127_5425255_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035,K12368 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001707 287.0
HKD2_k127_5425255_2 MerR, DNA binding - - - 0.000000000000000000000000000000000004461 141.0
HKD2_k127_5425255_3 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000002519 67.0
HKD2_k127_5425255_4 cytochrome - - - 0.0007138 50.0
HKD2_k127_5437139_0 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 387.0
HKD2_k127_5437139_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 320.0
HKD2_k127_5437139_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000001044 222.0
HKD2_k127_5437139_3 DoxX K15977 - - 0.000000000000000000000000000000000000000000000000000003902 196.0
HKD2_k127_5437139_4 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000302 192.0
HKD2_k127_5437139_5 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000001187 145.0
HKD2_k127_5437139_6 WD-40 repeat - - - 0.0000000000000000000000000000003376 141.0
HKD2_k127_5440695_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 552.0
HKD2_k127_5440695_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02504,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 534.0
HKD2_k127_5440695_10 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001403 263.0
HKD2_k127_5440695_11 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000002769 224.0
HKD2_k127_5440695_12 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000009401 195.0
HKD2_k127_5440695_13 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000001146 182.0
HKD2_k127_5440695_14 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000002187 165.0
HKD2_k127_5440695_15 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000002803 154.0
HKD2_k127_5440695_16 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 0.00000000000000000000000000000001227 134.0
HKD2_k127_5440695_17 phosphorelay signal transduction system - - - 0.000000000000000000000000000001558 130.0
HKD2_k127_5440695_18 Vitamin K epoxide reductase family - - - 0.000000000000000000000000000005484 134.0
HKD2_k127_5440695_19 Tetratricopeptide repeat - - - 0.00006739 53.0
HKD2_k127_5440695_2 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 464.0
HKD2_k127_5440695_20 - - - - 0.0001063 54.0
HKD2_k127_5440695_3 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 403.0
HKD2_k127_5440695_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 374.0
HKD2_k127_5440695_5 PFAM 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 342.0
HKD2_k127_5440695_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 326.0
HKD2_k127_5440695_7 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 289.0
HKD2_k127_5440695_8 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000155 307.0
HKD2_k127_5440695_9 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004002 285.0
HKD2_k127_548921_0 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 473.0
HKD2_k127_5514913_0 serine-type peptidase activity K01303 - 3.4.19.1 3.086e-266 837.0
HKD2_k127_5514913_1 DNA polymerase K02337,K14162 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 590.0
HKD2_k127_5514913_10 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 342.0
HKD2_k127_5514913_11 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 302.0
HKD2_k127_5514913_12 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 293.0
HKD2_k127_5514913_13 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 289.0
HKD2_k127_5514913_14 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005048 281.0
HKD2_k127_5514913_15 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005102 285.0
HKD2_k127_5514913_16 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000173 279.0
HKD2_k127_5514913_17 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000003295 274.0
HKD2_k127_5514913_18 galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000001532 236.0
HKD2_k127_5514913_19 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000005613 230.0
HKD2_k127_5514913_2 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 510.0
HKD2_k127_5514913_20 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000000004713 207.0
HKD2_k127_5514913_21 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000009269 150.0
HKD2_k127_5514913_22 Fe-S iron-sulfur cluster assembly protein, NifU family K04488 - - 0.000000000000000000000000000000000004055 140.0
HKD2_k127_5514913_23 PFAM NADH-ubiquinone plastoquinone oxidoreductase, chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000008808 142.0
HKD2_k127_5514913_24 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - 0.000000000000000000000000000001427 132.0
HKD2_k127_5514913_25 transcriptional regulator, Rrf2 family - - - 0.00000000000000000000000000001872 123.0
HKD2_k127_5514913_26 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000003506 120.0
HKD2_k127_5514913_27 Thioredoxin - - - 0.00000000000000000000000004387 114.0
HKD2_k127_5514913_28 metal-dependent phosphoesterases (PHP family) K07053 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 0.00000000000000000000000009215 117.0
HKD2_k127_5514913_29 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000001856 117.0
HKD2_k127_5514913_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 481.0
HKD2_k127_5514913_30 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000982 104.0
HKD2_k127_5514913_32 Domain of unknown function (DUF4864) - - - 0.0000000000001394 81.0
HKD2_k127_5514913_33 Cell division protein FtsQ K03589 - - 0.0000000000003046 81.0
HKD2_k127_5514913_35 Aldo/keto reductase family K16950 - - 0.0000003744 58.0
HKD2_k127_5514913_36 Evidence 5 No homology to any previously reported sequences - - - 0.000001176 56.0
HKD2_k127_5514913_4 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 440.0
HKD2_k127_5514913_5 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 407.0
HKD2_k127_5514913_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 403.0
HKD2_k127_5514913_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 405.0
HKD2_k127_5514913_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 398.0
HKD2_k127_5514913_9 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 378.0
HKD2_k127_553483_0 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 0.0 1380.0
HKD2_k127_553483_1 S-acyltransferase activity K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007684 594.0
HKD2_k127_553483_10 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000001711 109.0
HKD2_k127_553483_11 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000006774 101.0
HKD2_k127_553483_12 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.000000000000000000003955 103.0
HKD2_k127_553483_13 Tetratricopeptide repeat - - - 0.0000000000000000002404 93.0
HKD2_k127_553483_14 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000001156 71.0
HKD2_k127_553483_15 Calcineurin-like phosphoesterase - - - 0.000000000001308 78.0
HKD2_k127_553483_16 Protein of unknown function (DUF2752) - - - 0.0000000003612 66.0
HKD2_k127_553483_17 TM2 domain - - - 0.00006187 52.0
HKD2_k127_553483_18 AntiSigma factor - - - 0.0009338 49.0
HKD2_k127_553483_2 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 285.0
HKD2_k127_553483_3 RelA SpoT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000003143 233.0
HKD2_k127_553483_4 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000002272 221.0
HKD2_k127_553483_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000215 196.0
HKD2_k127_553483_6 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000002156 141.0
HKD2_k127_553483_7 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000007464 132.0
HKD2_k127_553483_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000007886 128.0
HKD2_k127_553483_9 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000004914 108.0
HKD2_k127_5597679_0 PFAM Aldehyde dehydrogenase K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 361.0
HKD2_k127_5597679_10 Belongs to the UPF0296 family K09777 - - 0.0000000001055 65.0
HKD2_k127_5597679_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000003474 259.0
HKD2_k127_5597679_3 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003804 245.0
HKD2_k127_5597679_4 von Willebrand factor, type A - - - 0.00000000000000000000000000000000003316 153.0
HKD2_k127_5597679_5 Mitochondrial small ribosomal subunit Rsm22 - - - 0.00000000000000000000000000009791 134.0
HKD2_k127_5597679_6 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000008275 115.0
HKD2_k127_5597679_7 response regulator receiver - - - 0.00000000000000000003351 94.0
HKD2_k127_5597679_8 Dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000597 93.0
HKD2_k127_5597679_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000003528 96.0
HKD2_k127_5602606_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 574.0
HKD2_k127_5602606_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 422.0
HKD2_k127_5602606_10 containing protein - GO:0003008,GO:0003674,GO:0005488,GO:0005518,GO:0005575,GO:0005576,GO:0007600,GO:0007605,GO:0008150,GO:0008360,GO:0022603,GO:0022604,GO:0031012,GO:0032501,GO:0044421,GO:0044877,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050954,GO:0051128,GO:0065007,GO:0065008 - 0.00000009268 62.0
HKD2_k127_5602606_2 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007475 374.0
HKD2_k127_5602606_3 Belongs to the ClpA ClpB family K03695,K03696 - - 0.000000000000000000000000000000000000000002225 174.0
HKD2_k127_5602606_4 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000001402 156.0
HKD2_k127_5602606_5 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000002625 140.0
HKD2_k127_5602606_6 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000003761 138.0
HKD2_k127_5602606_7 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07081,K11782,K11784 - 1.21.98.1,4.2.1.151 0.00000000000000000000000000001533 130.0
HKD2_k127_5602606_8 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000002692 120.0
HKD2_k127_5616944_0 B12 binding domain K00548 - 2.1.1.13 0.0 1307.0
HKD2_k127_5616944_1 OPT oligopeptide transporter protein - - - 5.585e-309 959.0
HKD2_k127_5616944_10 ECF sigma factor K03088 - - 0.0000000000000001094 93.0
HKD2_k127_5616944_2 PFAM sigma-54 factor interaction domain-containing protein K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 371.0
HKD2_k127_5616944_3 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 357.0
HKD2_k127_5616944_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 320.0
HKD2_k127_5616944_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000002661 218.0
HKD2_k127_5616944_6 intracellular protease K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000586 212.0
HKD2_k127_5616944_7 orotate phosphoribosyltransferase activity K00762 - 2.4.2.10 0.000000000000000000000000000001344 128.0
HKD2_k127_5616944_8 - - - - 0.0000000000000000000000004269 117.0
HKD2_k127_5616944_9 AAA domain (Cdc48 subfamily) - - - 0.00000000000000008629 85.0
HKD2_k127_5631885_0 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000006155 250.0
HKD2_k127_5631885_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000001277 171.0
HKD2_k127_5631885_2 Secretion protein K01993 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000001833 152.0
HKD2_k127_5631885_3 domain, Protein - - - 0.00000000000000000000002869 115.0
HKD2_k127_564556_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1327.0
HKD2_k127_564556_1 PFAM Pyrrolo-quinoline quinone K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000001505 246.0
HKD2_k127_564556_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000007186 212.0
HKD2_k127_5655136_0 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 345.0
HKD2_k127_5655136_1 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001011 286.0
HKD2_k127_5655136_2 Belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003046 276.0
HKD2_k127_5655136_3 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004369 276.0
HKD2_k127_5655136_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000008991 235.0
HKD2_k127_5690791_0 phosphorelay signal transduction system K02481,K07713,K07714 - - 0.00000000000000000000000000000000000000000000000000000000004528 223.0
HKD2_k127_5690791_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000001567 199.0
HKD2_k127_5690791_2 PFAM Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000001915 193.0
HKD2_k127_5690791_3 ASPIC and UnbV - - - 0.000000000000000000000001344 111.0
HKD2_k127_5694852_0 phosphohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 432.0
HKD2_k127_5694852_1 Site-specific recombinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 393.0
HKD2_k127_5694852_2 - - - - 0.00000000000000000000000000000000018 137.0
HKD2_k127_5694852_3 Domain of unknown function (DUF4388) - - - 0.00000000000000000000004763 115.0
HKD2_k127_5694852_4 - - - - 0.0000000003593 64.0
HKD2_k127_5698181_0 Domain of unknown function (DUF4445) - - - 4.879e-194 619.0
HKD2_k127_5698181_1 Protein of unknown function (DUF692) K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 433.0
HKD2_k127_5698181_2 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008855 436.0
HKD2_k127_5698181_3 Alpha/beta hydrolase family K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 390.0
HKD2_k127_5698181_4 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 378.0
HKD2_k127_5698181_5 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002219 259.0
HKD2_k127_5698181_6 methionine synthase - - - 0.00000000000000000000000000000314 138.0
HKD2_k127_5698181_7 Putative DNA-binding domain - - - 0.000000000000000000000000002421 117.0
HKD2_k127_5698181_8 - - - - 0.000000000000000001552 93.0
HKD2_k127_5698181_9 Homocysteine S-methyltransferase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.00000008272 60.0
HKD2_k127_5706899_0 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 351.0
HKD2_k127_5706899_1 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 327.0
HKD2_k127_5706899_2 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 309.0
HKD2_k127_5706899_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007459 271.0
HKD2_k127_5706899_4 Peptidyl-prolyl cis-trans - - - 0.00000000000000000000000000000000000000000000000001008 185.0
HKD2_k127_5706899_5 NADPH-quinone reductase (modulator of drug activity B) K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000002126 183.0
HKD2_k127_5706899_6 Phosphoglycerate mutase family K08296 - - 0.000000000000000000002749 99.0
HKD2_k127_5708223_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 603.0
HKD2_k127_5708223_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 402.0
HKD2_k127_5708223_10 Domain of unknown function (DUF4340) - - - 0.000000000000000000000000000000000006772 153.0
HKD2_k127_5708223_11 Pup-ligase protein K20814 - 3.5.1.119 0.000000000001599 67.0
HKD2_k127_5708223_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 359.0
HKD2_k127_5708223_3 ATPase activity K01990,K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 351.0
HKD2_k127_5708223_4 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 341.0
HKD2_k127_5708223_5 ABC-type uncharacterized transport system K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005916 272.0
HKD2_k127_5708223_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000002105 260.0
HKD2_k127_5708223_7 - K01992 - - 0.000000000000000000000000000000000000000000000000008059 190.0
HKD2_k127_5708223_8 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000006274 182.0
HKD2_k127_5708223_9 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000001104 186.0
HKD2_k127_5768862_0 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 387.0
HKD2_k127_5768862_1 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000002121 143.0
HKD2_k127_5768862_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000196 140.0
HKD2_k127_5768862_3 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000008206 117.0
HKD2_k127_5768862_4 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000004613 107.0
HKD2_k127_5776175_0 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 444.0
HKD2_k127_5776175_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 409.0
HKD2_k127_5776175_10 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000002884 134.0
HKD2_k127_5776175_11 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.00000000000000000000000000001872 123.0
HKD2_k127_5776175_12 regulation of translation K05808,K05809 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.00000000000000000000000001536 116.0
HKD2_k127_5776175_13 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000005928 105.0
HKD2_k127_5776175_14 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K09774 - - 0.000000001851 71.0
HKD2_k127_5776175_15 peptidyl-tyrosine sulfation - - - 0.00000006491 61.0
HKD2_k127_5776175_2 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 375.0
HKD2_k127_5776175_3 PFAM ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 340.0
HKD2_k127_5776175_4 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 318.0
HKD2_k127_5776175_5 TolB amino-terminal domain K03641 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 311.0
HKD2_k127_5776175_6 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 291.0
HKD2_k127_5776175_7 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.000000000000000000000000000000000000000000000000001162 199.0
HKD2_k127_5776175_8 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000006323 155.0
HKD2_k127_5776175_9 PFAM OmpA MotB domain protein K03640 - - 0.000000000000000000000000000000000188 139.0
HKD2_k127_5794718_0 cellulose binding - - - 0.0 1168.0
HKD2_k127_5794718_1 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000204 225.0
HKD2_k127_5794718_2 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000003946 222.0
HKD2_k127_5794718_3 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000006432 141.0
HKD2_k127_5794718_4 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000001173 113.0
HKD2_k127_5794718_5 SnoaL-like domain - - - 0.00000000000000000000004663 116.0
HKD2_k127_5794718_6 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.000000000000000000001601 111.0
HKD2_k127_5794718_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000001016 104.0
HKD2_k127_5794718_8 Antibiotic biosynthesis monooxygenase - - - 0.0000001668 57.0
HKD2_k127_581058_0 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 432.0
HKD2_k127_581058_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000005321 163.0
HKD2_k127_581058_3 Zn-dependent peptidases K07263 - - 0.00000000000000000001072 96.0
HKD2_k127_5813415_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 6.447e-212 673.0
HKD2_k127_5813415_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 426.0
HKD2_k127_5813415_2 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 350.0
HKD2_k127_5813415_3 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000001119 197.0
HKD2_k127_5817075_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 6.977e-198 634.0
HKD2_k127_5817075_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 549.0
HKD2_k127_5817075_2 Aminotransferase class-V K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 368.0
HKD2_k127_5817075_3 acyl-CoA dehydrogenase activity K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 313.0
HKD2_k127_5817075_4 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007177 254.0
HKD2_k127_5817075_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000001406 203.0
HKD2_k127_5817075_6 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000001755 136.0
HKD2_k127_5817075_7 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000001844 130.0
HKD2_k127_5817075_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000001528 106.0
HKD2_k127_5817075_9 Prokaryotic RING finger family 1 - - - 0.00000008048 57.0
HKD2_k127_5840759_0 Predicted membrane protein (DUF2339) - - - 2.2e-208 683.0
HKD2_k127_5840759_1 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 591.0
HKD2_k127_5840759_10 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000001706 227.0
HKD2_k127_5840759_11 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000883 224.0
HKD2_k127_5840759_12 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000001681 218.0
HKD2_k127_5840759_13 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000004606 192.0
HKD2_k127_5840759_14 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000002813 150.0
HKD2_k127_5840759_15 - - - - 0.000000000000000000000000000000000000007299 160.0
HKD2_k127_5840759_16 AMMECR1 K09141 - - 0.00000000000000000000000000000000000001998 155.0
HKD2_k127_5840759_17 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000004298 142.0
HKD2_k127_5840759_18 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000005707 138.0
HKD2_k127_5840759_19 domain protein K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000578 125.0
HKD2_k127_5840759_2 Glycine cleavage system P-protein K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 573.0
HKD2_k127_5840759_20 Glycosyl transferase family 2 - - - 0.00000000000000000000000000001353 132.0
HKD2_k127_5840759_21 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.000000000000000000007189 108.0
HKD2_k127_5840759_22 - - - - 0.000000000000004601 81.0
HKD2_k127_5840759_23 Helix-turn-helix domain - - - 0.0000000000002174 75.0
HKD2_k127_5840759_24 - - - - 0.000000000001841 77.0
HKD2_k127_5840759_25 - - - - 0.000000005351 64.0
HKD2_k127_5840759_26 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00007118 52.0
HKD2_k127_5840759_3 Protein of unknown function (DUF3999) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 483.0
HKD2_k127_5840759_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 445.0
HKD2_k127_5840759_5 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 409.0
HKD2_k127_5840759_6 PFAM Glycosyl transferase family 2 K10012 - 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 350.0
HKD2_k127_5840759_7 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001254 291.0
HKD2_k127_5840759_8 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000123 271.0
HKD2_k127_5840759_9 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001108 255.0
HKD2_k127_5865953_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006539 507.0
HKD2_k127_5865953_1 heat shock protein binding K05516,K05801 - - 0.000000000000000004674 98.0
HKD2_k127_5865953_2 - - - - 0.00000000000003378 76.0
HKD2_k127_5893533_0 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 316.0
HKD2_k127_5893533_1 Pfam ABC transporter related K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001495 289.0
HKD2_k127_5893533_2 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006876 261.0
HKD2_k127_5893533_3 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000002106 238.0
HKD2_k127_5893533_4 PFAM Cobalt transport protein K02007,K02008 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000005427 220.0
HKD2_k127_5914966_0 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001309 280.0
HKD2_k127_5914966_1 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002882 278.0
HKD2_k127_5914966_2 response regulator, receiver K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002022 261.0
HKD2_k127_5914966_3 Histidine kinase K07646 - 2.7.13.3 0.00000000006509 73.0
HKD2_k127_5916731_0 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 532.0
HKD2_k127_5916731_1 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 299.0
HKD2_k127_5916731_2 GGDEF domain - - - 0.00000000000000000000264 106.0
HKD2_k127_5921847_0 PFAM SpoVR like protein K06415 - - 4.903e-206 658.0
HKD2_k127_5921847_1 Belongs to the UPF0229 family K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 534.0
HKD2_k127_5921847_2 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 318.0
HKD2_k127_5921847_3 Mitochondrial biogenesis AIM24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 282.0
HKD2_k127_5976771_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001831 269.0
HKD2_k127_5976771_1 beta-lactamase - - - 0.000000000000000000000000000000000000000000000000003735 191.0
HKD2_k127_5980956_0 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 311.0
HKD2_k127_5980956_1 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008105 276.0
HKD2_k127_5980956_2 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000003712 188.0
HKD2_k127_5980956_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000000002357 131.0
HKD2_k127_5980956_4 Peptidase M56 - - - 0.0000000000000000002417 102.0
HKD2_k127_5980956_5 PFAM Tetratricopeptide repeat - - - 0.000000000000005751 85.0
HKD2_k127_5980956_6 PFAM SMP-30 Gluconolaconase - - - 0.00003164 55.0
HKD2_k127_5990014_0 ATPase activity K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 460.0
HKD2_k127_5990014_1 ABC transporter K02047 - - 0.00000000000000000000000000000002797 126.0
HKD2_k127_6000367_0 Polyphosphate kinase 2 (PPK2) - - - 9.46e-214 674.0
HKD2_k127_6000367_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 335.0
HKD2_k127_6027225_0 Glutamine synthetase type III N terminal K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 479.0
HKD2_k127_6027225_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 443.0
HKD2_k127_6027225_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000005297 233.0
HKD2_k127_6027225_3 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.00000000000000000000002866 112.0
HKD2_k127_6054740_0 SPTR Glycosyl hydrolase, BNR repeat-containing protein - - - 6.345e-314 992.0
HKD2_k127_6054740_1 lysine 2,3-aminomutase K01843 - 5.4.3.2 3.926e-216 676.0
HKD2_k127_6054740_2 saccharopine dehydrogenase activity K19064 - 1.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 398.0
HKD2_k127_6054740_3 EAL domain - - - 0.00000000000000000000000000000000000000000003132 164.0
HKD2_k127_6072119_0 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 472.0
HKD2_k127_6072119_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 362.0
HKD2_k127_6072119_2 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004135 258.0
HKD2_k127_6072119_3 Mut7-C ubiquitin K09122 - - 0.000000000000000000000002441 112.0
HKD2_k127_6072119_4 ATP-binding protein K04562 - - 0.000000000000000000001228 108.0
HKD2_k127_6072119_5 - - - - 0.00000000000838 68.0
HKD2_k127_6099820_0 involved in outer membrane biogenesis K07289 - - 0.000000000000000000000000000000000000000000000000000000000000000000002383 256.0
HKD2_k127_6099820_1 Na -dependent transporter K03453 - - 0.00000000000000000000004737 110.0
HKD2_k127_6099820_2 sh3 domain protein - - - 0.0000000001029 67.0
HKD2_k127_6118923_0 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 1.615e-210 668.0
HKD2_k127_6118923_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 559.0
HKD2_k127_6118923_2 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 461.0
HKD2_k127_6118923_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 376.0
HKD2_k127_6118923_4 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 327.0
HKD2_k127_6118923_5 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005331 261.0
HKD2_k127_6118923_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000003585 198.0
HKD2_k127_6118923_7 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000005818 147.0
HKD2_k127_6118923_8 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000007566 145.0
HKD2_k127_6118923_9 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000009612 118.0
HKD2_k127_6141087_0 Belongs to the GPI family K01810 - 5.3.1.9 2.113e-276 863.0
HKD2_k127_6141087_1 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000006315 220.0
HKD2_k127_6141087_2 - - - - 0.0000000000000000000000521 104.0
HKD2_k127_6141087_3 oxidoreductase activity K12511 - - 0.00000000000000000003355 104.0
HKD2_k127_6141087_5 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000007569 77.0
HKD2_k127_6141087_7 Sigma-70, region 4 - - - 0.000001136 53.0
HKD2_k127_6144742_0 amp-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 366.0
HKD2_k127_6144742_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007224 334.0
HKD2_k127_6144742_10 DnaJ molecular chaperone homology domain - - - 0.000001281 59.0
HKD2_k127_6144742_2 tRNA processing K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001047 271.0
HKD2_k127_6144742_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946,K07123 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000006705 226.0
HKD2_k127_6144742_4 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000001524 190.0
HKD2_k127_6144742_5 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000001525 171.0
HKD2_k127_6144742_6 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000006023 147.0
HKD2_k127_6144742_7 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.0000000000000000000000004903 109.0
HKD2_k127_6144742_9 BNR Asp-box repeat - - - 0.00000000002008 77.0
HKD2_k127_6182124_0 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000001132 163.0
HKD2_k127_6182124_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000004061 139.0
HKD2_k127_6182124_2 integral membrane protein - - - 0.0000000000000008375 83.0
HKD2_k127_6238271_0 SMART von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000001537 204.0
HKD2_k127_6238271_1 Carbohydrate family 9 binding domain-like - - - 0.000000122 64.0
HKD2_k127_6254915_0 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 489.0
HKD2_k127_6254915_1 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000002908 164.0
HKD2_k127_62649_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 310.0
HKD2_k127_62649_1 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002487 263.0
HKD2_k127_62649_2 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000009857 250.0
HKD2_k127_62649_3 COG0747 ABC-type dipeptide transport system, periplasmic component K02035,K12368 - - 0.0000000000000000000000000000000000000000000000000000000000000005717 239.0
HKD2_k127_62649_4 Site-specific recombinase - - - 0.0000000000000000000000000000008935 129.0
HKD2_k127_62649_5 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000002196 119.0
HKD2_k127_6301753_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 3.169e-214 676.0
HKD2_k127_6301753_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 561.0
HKD2_k127_6301753_2 outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 355.0
HKD2_k127_6301753_3 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 351.0
HKD2_k127_6301753_4 NUDIX domain K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000003701 217.0
HKD2_k127_6301753_5 YsiA-like protein, C-terminal region K09017 - - 0.0000000000000001367 87.0
HKD2_k127_6301753_6 - - - - 0.0003823 50.0
HKD2_k127_6318623_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 309.0
HKD2_k127_6318623_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 293.0
HKD2_k127_6318623_10 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000003461 125.0
HKD2_k127_6318623_11 Fibronectin type 3 domain - - - 0.000000000000000004923 100.0
HKD2_k127_6318623_2 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000002897 265.0
HKD2_k127_6318623_3 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001402 253.0
HKD2_k127_6318623_4 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000009524 243.0
HKD2_k127_6318623_5 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000001928 188.0
HKD2_k127_6318623_6 arylsulfatase A - - - 0.000000000000000000000000000000000000000000002073 183.0
HKD2_k127_6318623_7 Allophanate hydrolase subunit 2 - - - 0.00000000000000000000000000000000000000001209 168.0
HKD2_k127_6318623_8 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000002064 136.0
HKD2_k127_6318623_9 Allophanate hydrolase subunit 2 - - - 0.000000000000000000000000000001541 131.0
HKD2_k127_6322601_0 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 554.0
HKD2_k127_6322601_1 membrane protein, TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 430.0
HKD2_k127_6322601_2 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 364.0
HKD2_k127_6322601_3 Tyrosine recombinase XerD K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001094 282.0
HKD2_k127_6322601_4 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.000000000000000000000009697 106.0
HKD2_k127_6322601_5 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity - - - 0.0000000000001938 73.0
HKD2_k127_6322601_6 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000003109 62.0
HKD2_k127_6337133_0 Surface antigen K07277,K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000718 379.0
HKD2_k127_6350658_0 PFAM Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000003093 160.0
HKD2_k127_6350658_1 pfam nudix K03574 - 3.6.1.55 0.0000000000000000000000000000000002932 135.0
HKD2_k127_6350658_2 Tetratricopeptide repeat - - - 0.00000000000000000000000001085 117.0
HKD2_k127_6369440_0 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 370.0
HKD2_k127_6369440_1 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 312.0
HKD2_k127_6369440_2 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 299.0
HKD2_k127_6369440_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000026 152.0
HKD2_k127_6369440_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000008676 146.0
HKD2_k127_6369440_5 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000001156 134.0
HKD2_k127_6369440_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000007955 115.0
HKD2_k127_6378382_0 Inhibitor of apoptosis-promoting Bax1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 319.0
HKD2_k127_6378382_1 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 316.0
HKD2_k127_6378382_2 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000001565 147.0
HKD2_k127_6405845_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 595.0
HKD2_k127_6405845_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 432.0
HKD2_k127_6405845_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 402.0
HKD2_k127_6405845_3 Pyrroloquinoline quinone biosynthesis protein PqqB K06136 - - 0.000000000000000000000000000000000000000000000000000000000000000001151 238.0
HKD2_k127_6405845_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000007815 229.0
HKD2_k127_6405845_5 PQQ enzyme repeat - - - 0.000000000000000000000000000000000000003849 164.0
HKD2_k127_6405845_6 DinB family - - - 0.0000000000000000000000000000002461 128.0
HKD2_k127_6405845_7 PFAM KWG Leptospira - - - 0.00000000000000000000009482 102.0
HKD2_k127_6405845_8 COG0457 FOG TPR repeat - - - 0.0003438 54.0
HKD2_k127_6414254_0 Type III secretion protein K03230 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 357.0
HKD2_k127_6414254_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000009512 101.0
HKD2_k127_6428162_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005332 582.0
HKD2_k127_6428162_1 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000009005 235.0
HKD2_k127_6428162_2 HAMP domain - - - 0.000000000000000000000000000000000008111 151.0
HKD2_k127_6428162_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000002409 100.0
HKD2_k127_6451732_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 351.0
HKD2_k127_6451732_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000003758 160.0
HKD2_k127_6451732_2 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity - - - 0.00000000000000000000000000000000000000003764 159.0
HKD2_k127_6451732_3 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000001946 134.0
HKD2_k127_6472322_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 439.0
HKD2_k127_6472322_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 313.0
HKD2_k127_6472322_10 Forkhead associated domain - - - 0.00000000001805 73.0
HKD2_k127_6472322_11 DGQHR domain - - - 0.0000000001304 73.0
HKD2_k127_6472322_12 Tetratricopeptide repeat - - - 0.0006946 51.0
HKD2_k127_6472322_2 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000005418 247.0
HKD2_k127_6472322_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001293 214.0
HKD2_k127_6472322_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000009829 192.0
HKD2_k127_6472322_5 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000001385 171.0
HKD2_k127_6472322_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000006193 143.0
HKD2_k127_6472322_7 Forkhead associated domain - - - 0.0000000000000000000000006369 122.0
HKD2_k127_6472322_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000001047 107.0
HKD2_k127_6472322_9 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000003052 87.0
HKD2_k127_6486938_0 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003595 273.0
HKD2_k127_6486938_1 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000128 144.0
HKD2_k127_6494551_0 General secretory system II protein E domain protein K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 466.0
HKD2_k127_6494551_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 413.0
HKD2_k127_6494551_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000326 245.0
HKD2_k127_6494551_3 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000001033 194.0
HKD2_k127_6494551_4 - - - - 0.000000000000000000000000000000000000000000000002589 182.0
HKD2_k127_6494551_5 (Hpt) domain - - - 0.0000000000000000000000004407 113.0
HKD2_k127_6494551_6 PFAM response regulator receiver - - - 0.000000000000000000004009 98.0
HKD2_k127_6494551_7 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000002723 100.0
HKD2_k127_6521130_0 Carbon starvation protein K06200 - - 2.182e-223 708.0
HKD2_k127_6521130_1 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 554.0
HKD2_k127_6521130_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 376.0
HKD2_k127_6543283_0 Radical_SAM C-terminal domain K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001974 291.0
HKD2_k127_6543283_1 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000264 261.0
HKD2_k127_6543283_2 PFAM Protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000003648 133.0
HKD2_k127_6548744_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 572.0
HKD2_k127_6548744_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 332.0
HKD2_k127_6548744_2 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000642 237.0
HKD2_k127_6548744_3 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000009484 206.0
HKD2_k127_6559229_0 Tricorn protease C1 domain K08676 - - 0.0 1219.0
HKD2_k127_6559229_1 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 538.0
HKD2_k127_6559229_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 532.0
HKD2_k127_6559229_3 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 339.0
HKD2_k127_656547_0 Sodium:solute symporter family K03307 - - 9.013e-224 715.0
HKD2_k127_656547_1 Belongs to the GHMP kinase family K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 369.0
HKD2_k127_656547_2 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 309.0
HKD2_k127_656547_3 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000001217 220.0
HKD2_k127_656547_4 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000007689 203.0
HKD2_k127_656547_5 Opacity family porin protein - - - 0.0000000019 67.0
HKD2_k127_6621007_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 410.0
HKD2_k127_6621007_1 Dimerisation domain - - - 0.00000000000000000000000006564 113.0
HKD2_k127_6634667_0 B12 binding domain - - - 1.282e-195 621.0
HKD2_k127_6634667_1 arylsulfatase A - - - 0.0000000000000000000000000000004057 130.0
HKD2_k127_6634667_2 Thioesterase superfamily - - - 0.0000000000000000000000001152 111.0
HKD2_k127_6634667_3 Sensor diguanylate cyclase, GAF domain-containing - - - 0.00000000000000000005234 104.0
HKD2_k127_6677308_0 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 498.0
HKD2_k127_6677308_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007899 381.0
HKD2_k127_6677308_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 310.0
HKD2_k127_6677308_3 ATPase (AAA superfamily K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007745 271.0
HKD2_k127_6677308_4 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000001403 240.0
HKD2_k127_6677308_5 DNA-binding transcription factor activity - - - 0.00000000000003818 84.0
HKD2_k127_6677308_6 - - - - 0.00003816 53.0
HKD2_k127_669084_0 4Fe-4S dicluster domain K00184 - - 9.188e-292 927.0
HKD2_k127_669084_1 Polysulphide reductase, NrfD K00185 - - 4.131e-231 722.0
HKD2_k127_669084_10 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000006654 160.0
HKD2_k127_669084_11 cytochrome c - - - 0.0000000000000000000000000000000000000008564 156.0
HKD2_k127_669084_12 Surface antigen - - - 0.0000000000000000000000000000001774 139.0
HKD2_k127_669084_13 cell septum assembly - - - 0.000000000000000000000000000003051 134.0
HKD2_k127_669084_14 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.000000000000000000004598 103.0
HKD2_k127_669084_15 ATP:ADP antiporter activity K03301 - - 0.0000000000000000204 95.0
HKD2_k127_669084_2 nitrate reductase beta subunit K00371 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0033554,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 3.188e-229 718.0
HKD2_k127_669084_3 PFAM Major Facilitator Superfamily K02575 - - 9.272e-194 617.0
HKD2_k127_669084_4 Transporter K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 590.0
HKD2_k127_669084_5 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 355.0
HKD2_k127_669084_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 337.0
HKD2_k127_669084_7 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K17050 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000366 257.0
HKD2_k127_669084_8 nitrate reductase activity K00370,K00374,K02575 GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000184 214.0
HKD2_k127_669084_9 PFAM Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000007575 188.0
HKD2_k127_6705414_0 PFAM amino acid permease-associated region K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009565 529.0
HKD2_k127_6705414_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 357.0
HKD2_k127_6705414_2 Major Facilitator - - - 0.00000000000000000000000000000001501 142.0
HKD2_k127_6733510_0 Response regulator, receiver K01007 - 2.7.9.2 0.0 1302.0
HKD2_k127_6733510_1 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.0 1156.0
HKD2_k127_6733510_10 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000002358 59.0
HKD2_k127_6733510_2 glutamate dehydrogenase [NAD(P)+] activity K00262 - 1.4.1.4 4.123e-255 791.0
HKD2_k127_6733510_3 glutamate dehydrogenase [NAD(P)+] activity K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 1.65e-224 702.0
HKD2_k127_6733510_4 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 607.0
HKD2_k127_6733510_5 metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 312.0
HKD2_k127_6733510_6 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007264 223.0
HKD2_k127_6733510_7 ethanolamine catabolic process - - - 0.00000000000000000000000000000000223 131.0
HKD2_k127_6733510_8 - - - - 0.00000000000000000000003284 101.0
HKD2_k127_6733510_9 Belongs to the LOG family - - - 0.000000000000000001577 94.0
HKD2_k127_6737111_0 PFAM acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 473.0
HKD2_k127_6737111_1 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007697 396.0
HKD2_k127_6737111_2 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000000000003334 211.0
HKD2_k127_6737111_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000001219 205.0
HKD2_k127_6737111_4 AAA domain - - - 0.000000000000000000000000000000000000000000002613 172.0
HKD2_k127_676281_0 Glycosyl hydrolase family 57 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 429.0
HKD2_k127_676281_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 342.0
HKD2_k127_6774209_0 Elongation factor SelB winged helix 3 K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 491.0
HKD2_k127_6774209_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 460.0
HKD2_k127_6774209_10 Glyoxalase-like domain - - - 0.000000000000000000002186 100.0
HKD2_k127_6774209_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000009743 61.0
HKD2_k127_6774209_12 amino acid activation for nonribosomal peptide biosynthetic process K06045 - 4.2.1.129,5.4.99.17 0.00009429 51.0
HKD2_k127_6774209_13 membrane - - - 0.0002809 54.0
HKD2_k127_6774209_2 PFAM Uncharacterised conserved protein UCP016719 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 419.0
HKD2_k127_6774209_3 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 332.0
HKD2_k127_6774209_4 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000006984 245.0
HKD2_k127_6774209_5 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000007133 204.0
HKD2_k127_6774209_6 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000008574 201.0
HKD2_k127_6774209_7 TIGRFAM phosphomethylpyrimidine kinase K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000001955 189.0
HKD2_k127_6774209_8 DNA photolyase activity K03716 - 4.1.99.14 0.000000000000000000000000000000000000000008079 167.0
HKD2_k127_6774209_9 - - - - 0.000000000000000000000000000000001318 138.0
HKD2_k127_6804659_0 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 370.0
HKD2_k127_6804659_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 362.0
HKD2_k127_6804659_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 321.0
HKD2_k127_6804659_3 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 284.0
HKD2_k127_6804659_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002191 295.0
HKD2_k127_6804659_5 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000115 279.0
HKD2_k127_6804659_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000001162 199.0
HKD2_k127_6804659_7 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000005821 104.0
HKD2_k127_683337_0 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 474.0
HKD2_k127_683337_1 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000009178 254.0
HKD2_k127_683337_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001534 241.0
HKD2_k127_6836366_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 494.0
HKD2_k127_6836366_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001629 269.0
HKD2_k127_6836366_2 Pseudouridine synthase K06179,K06180 - 5.4.99.23,5.4.99.24 0.0000000000000000000000000000000000000000000000000000008873 201.0
HKD2_k127_6836366_3 Protein of unknown function (DUF1573) - - - 0.0000001681 63.0
HKD2_k127_6836770_0 - - - - 3.438e-302 966.0
HKD2_k127_6844047_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 444.0
HKD2_k127_6844047_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 440.0
HKD2_k127_6844047_2 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000000000000000005602 156.0
HKD2_k127_6844047_3 bacterial-type flagellum-dependent cell motility K20951,K20952 - - 0.000000000000000000000000000000003826 147.0
HKD2_k127_6844047_5 Protein conserved in bacteria - - - 0.000000004848 70.0
HKD2_k127_6887866_0 Alpha-amylase domain K01176 - 3.2.1.1 1.622e-212 672.0
HKD2_k127_6887866_1 Sugar ABC transporter permease K10109,K15770,K15771 - - 5.42e-203 653.0
HKD2_k127_6887866_10 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000003431 240.0
HKD2_k127_6887866_11 - - - - 0.000000000000000000000000000000000000000000000000000000000006283 235.0
HKD2_k127_6887866_12 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.00000000000000000000000000000000000000000000000000008923 213.0
HKD2_k127_6887866_13 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000001616 154.0
HKD2_k127_6887866_14 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000008021 113.0
HKD2_k127_6887866_15 Belongs to the peptidase S8 family K14645 GO:0005575,GO:0005576 - 0.000000000008308 79.0
HKD2_k127_6887866_2 - - - - 1.251e-202 655.0
HKD2_k127_6887866_3 Bacterial extracellular solute-binding protein K10108,K15770 - - 6.233e-196 619.0
HKD2_k127_6887866_4 Belongs to the ABC transporter superfamily K05816,K10112 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 516.0
HKD2_k127_6887866_5 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 516.0
HKD2_k127_6887866_6 Binding-protein-dependent transport system inner membrane component K10110,K15772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 469.0
HKD2_k127_6887866_7 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 397.0
HKD2_k127_6887866_8 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 296.0
HKD2_k127_6887866_9 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001516 261.0
HKD2_k127_6906238_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001189 253.0
HKD2_k127_6906238_1 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000002192 213.0
HKD2_k127_6906238_2 chaperone-mediated protein folding - - - 0.00000000000000002153 93.0
HKD2_k127_6906321_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1090.0
HKD2_k127_6906321_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 460.0
HKD2_k127_6906321_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 360.0
HKD2_k127_6906321_3 Glycogen recognition site of AMP-activated protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 335.0
HKD2_k127_6906321_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.0000000000000000000000000000000003835 136.0
HKD2_k127_6906321_5 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000006371 128.0
HKD2_k127_6906321_6 Protein of unknown function (DUF971) K03593 - - 0.000000000000000000000000001491 116.0
HKD2_k127_6906321_7 Rv0623-like transcription factor K19687 - - 0.0000000000000001005 82.0
HKD2_k127_6933801_0 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 354.0
HKD2_k127_6933801_1 racemase activity, acting on amino acids and derivatives K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 297.0
HKD2_k127_6933801_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009689 293.0
HKD2_k127_6933801_3 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002803 304.0
HKD2_k127_6933801_4 COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein - - - 0.0000000000000000000000000002428 121.0
HKD2_k127_6933801_5 RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000002679 119.0
HKD2_k127_6933801_6 cell redox homeostasis - - - 0.0000000000000000000000004007 117.0
HKD2_k127_6951974_0 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000000000000000000000000000000000001797 239.0
HKD2_k127_6951974_1 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000000000000000000000007344 218.0
HKD2_k127_6951974_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000136 169.0
HKD2_k127_6951974_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000001957 183.0
HKD2_k127_6951974_4 Tetratricopeptide repeat - - - 0.00000000004401 71.0
HKD2_k127_6951974_5 Putative zinc-finger - - - 0.0000001828 63.0
HKD2_k127_6951974_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0002644 53.0
HKD2_k127_6979727_0 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 597.0
HKD2_k127_6979727_1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 322.0
HKD2_k127_6979727_2 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 312.0
HKD2_k127_6979727_3 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 291.0
HKD2_k127_6979727_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000003233 201.0
HKD2_k127_6979727_5 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000001046 187.0
HKD2_k127_6979727_6 transcriptional regulator K04761 - - 0.000000000000000000000000000000000000000000000161 175.0
HKD2_k127_6979727_7 PFAM small multidrug resistance protein K03297,K11741 - - 0.0000000000000000000000000000000000236 138.0
HKD2_k127_6979727_8 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K03769,K07533 - 5.2.1.8 0.00000000000000000000000003103 121.0
HKD2_k127_6989010_0 COGs COG0433 ATPase K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008687 498.0
HKD2_k127_6989010_1 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000006696 248.0
HKD2_k127_6989010_2 Belongs to the N-Me-Phe pilin family - - - 0.0000000000000000000000005583 111.0
HKD2_k127_6989010_3 ATPase involved in DNA repair K03546 - - 0.00000000000000000000000337 119.0
HKD2_k127_6997748_0 GXGXG motif - - - 8.197e-260 822.0
HKD2_k127_6997748_1 Glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006826 606.0
HKD2_k127_6997748_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 405.0
HKD2_k127_6997748_3 glutamate synthase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001321 312.0
HKD2_k127_6997748_4 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000006878 209.0
HKD2_k127_6997748_5 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000004855 141.0
HKD2_k127_6997748_6 - - - - 0.0000000000000000000000000406 109.0
HKD2_k127_6997748_7 - - - - 0.00000000000000000321 90.0
HKD2_k127_7009608_0 beta-galactosidase activity K15855 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575 3.2.1.165 8.801e-273 873.0
HKD2_k127_7009608_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 541.0
HKD2_k127_7009608_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000001651 144.0
HKD2_k127_7009608_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 448.0
HKD2_k127_7009608_3 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 377.0
HKD2_k127_7009608_4 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 376.0
HKD2_k127_7009608_5 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 320.0
HKD2_k127_7009608_6 transcriptional K02081 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007403 275.0
HKD2_k127_7009608_7 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000001138 265.0
HKD2_k127_7009608_8 Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000001447 250.0
HKD2_k127_7009608_9 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000001934 254.0
HKD2_k127_7022090_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K18138 - - 0.0 1634.0
HKD2_k127_7022090_1 GMP synthase (glutamine-hydrolyzing) activity K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 537.0
HKD2_k127_7022090_2 HlyD membrane-fusion protein of T1SS K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 514.0
HKD2_k127_7022090_3 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 481.0
HKD2_k127_7022090_4 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 383.0
HKD2_k127_7022090_5 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008952 367.0
HKD2_k127_7022090_6 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000001979 176.0
HKD2_k127_7022090_7 diguanylate cyclase - - - 0.0000000000000000000000000298 127.0
HKD2_k127_7022090_8 - - - - 0.00000000000000000001176 94.0
HKD2_k127_7045623_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 549.0
HKD2_k127_7045623_1 COG1473 Metal-dependent amidase aminoacylase carboxypeptidase K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 412.0
HKD2_k127_7045623_2 Type ii and iii secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 335.0
HKD2_k127_7045623_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000008118 193.0
HKD2_k127_7079604_0 Alpha-amylase domain K01176 - 3.2.1.1 3.454e-209 679.0
HKD2_k127_7079604_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 340.0
HKD2_k127_7079604_2 Belongs to the peptidase S8 family K08651,K14743 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000002761 229.0
HKD2_k127_7079604_3 DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000008929 217.0
HKD2_k127_7079604_4 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000002476 100.0
HKD2_k127_7102290_0 PFAM isocitrate isopropylmalate dehydrogenase K00052,K07246 - 1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009582 383.0
HKD2_k127_7102290_1 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 299.0
HKD2_k127_7102290_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000007108 220.0
HKD2_k127_7102290_3 NMT1/THI5 like - - - 0.000000000000000000000000000000000000000000000002069 194.0
HKD2_k127_7102290_4 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000000000000007117 160.0
HKD2_k127_7102290_6 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000005009 154.0
HKD2_k127_7102290_7 von Willebrand factor (vWF) type A domain K07114 - - 0.00001401 55.0
HKD2_k127_7114412_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 544.0
HKD2_k127_7114412_1 radical SAM domain protein K15045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 323.0
HKD2_k127_7114412_2 PFAM Metal-dependent phosphohydrolase, HD K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002383 293.0
HKD2_k127_7114412_3 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000002812 205.0
HKD2_k127_7114412_4 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000005312 157.0
HKD2_k127_7114412_5 - - - - 0.000000000000000000000000002667 128.0
HKD2_k127_7114412_6 SNARE associated Golgi protein - - - 0.000000000000000000003507 100.0
HKD2_k127_7114412_7 - - - - 0.00000000002397 74.0
HKD2_k127_7128720_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 508.0
HKD2_k127_7128720_1 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001482 284.0
HKD2_k127_7128720_10 signal peptide processing K13280 - 3.4.21.89 0.00000000000000001217 91.0
HKD2_k127_7128720_2 Belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001756 274.0
HKD2_k127_7128720_3 pfam abc K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001939 276.0
HKD2_k127_7128720_4 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006789 267.0
HKD2_k127_7128720_5 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.000000000000000000000000000000000000000000000000000001245 196.0
HKD2_k127_7128720_6 PFAM Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000006215 169.0
HKD2_k127_7128720_7 COG0262 Dihydrofolate reductase - - - 0.000000000000000000000000000000000000000001893 162.0
HKD2_k127_7128720_8 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000001158 151.0
HKD2_k127_7128720_9 PFAM extracellular solute-binding protein, family 3 K02030 - - 0.00000000000000000000000002552 118.0
HKD2_k127_7148049_0 Protein tyrosine kinase - - - 3.953e-210 683.0
HKD2_k127_7148049_1 Glycosyltransferase sugar-binding region containing DXD motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 313.0
HKD2_k127_7148049_2 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005173 278.0
HKD2_k127_7148049_3 Gaf domain - - - 0.000000000000000000000000000000000000000000000000000005158 199.0
HKD2_k127_7148049_4 Glycosyl Transferase K20444 - - 0.000000000000000000000000000000000000000000285 173.0
HKD2_k127_7148049_5 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000001862 163.0
HKD2_k127_7148049_6 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000001907 164.0
HKD2_k127_7148049_7 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000215 119.0
HKD2_k127_7153228_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006633 607.0
HKD2_k127_7153228_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 397.0
HKD2_k127_7153228_10 Tetratricopeptide repeat - - - 0.00000000000000000007458 104.0
HKD2_k127_7153228_2 Phosphoesterase, PA-phosphatase related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 291.0
HKD2_k127_7153228_3 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000001669 246.0
HKD2_k127_7153228_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.000000000000000000000000000000000000000000000000000005011 194.0
HKD2_k127_7153228_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.000000000000000000000000000000000001149 151.0
HKD2_k127_7153228_6 Phosphoribosyl transferase domain K02242 - - 0.00000000000000000000000000000000009298 144.0
HKD2_k127_7153228_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000002355 117.0
HKD2_k127_7153228_8 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000001198 101.0
HKD2_k127_7153228_9 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000364 104.0
HKD2_k127_7155491_0 Bacterial protein of unknown function (DUF885) - - - 2.922e-209 669.0
HKD2_k127_7155491_1 Peptidase S9, prolyl oligopeptidase active site domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 444.0
HKD2_k127_7173993_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1033.0
HKD2_k127_7173993_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000004831 122.0
HKD2_k127_7193472_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 468.0
HKD2_k127_7193472_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 363.0
HKD2_k127_7193472_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000002328 198.0
HKD2_k127_7193472_3 Dienelactone hydrolase family K06889 - - 0.000000000000000000000000000000000000001063 156.0
HKD2_k127_7193472_4 TIGRFAM photoactive yellow protein - - - 0.0000000000000000000000000006838 117.0
HKD2_k127_7217953_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 504.0
HKD2_k127_7217953_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 335.0
HKD2_k127_7217953_2 Tetratricopeptide repeat K20543 - - 0.00000000000000000000000000000000000000000000000000000000000009238 229.0
HKD2_k127_7217953_3 Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000002059 75.0
HKD2_k127_7260425_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 1.23e-267 836.0
HKD2_k127_7260425_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 471.0
HKD2_k127_7260425_2 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000006361 266.0
HKD2_k127_7260425_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000231 241.0
HKD2_k127_7260425_4 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000002352 229.0
HKD2_k127_7281530_0 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 438.0
HKD2_k127_7281530_1 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000008873 139.0
HKD2_k127_7281530_2 HAMP domain - - - 0.0000000000000000000009207 98.0
HKD2_k127_7314923_0 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 453.0
HKD2_k127_7314923_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000007988 269.0
HKD2_k127_7314923_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003211 254.0
HKD2_k127_7314923_3 PFAM HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001003 262.0
HKD2_k127_7314923_4 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000004113 219.0
HKD2_k127_7314923_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000005251 110.0
HKD2_k127_7314923_6 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000002192 86.0
HKD2_k127_7329014_0 PFAM 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006981 599.0
HKD2_k127_7329014_1 COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein - - - 0.00000000000000000000000000000000000000000000000000000000003144 209.0
HKD2_k127_7329014_2 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000000008451 203.0
HKD2_k127_7329014_3 Winged helix DNA-binding domain - - - 0.000000000000000000000000555 109.0
HKD2_k127_7329014_4 oxidoreductase activity - - - 0.0000000000000002826 81.0
HKD2_k127_7339156_0 electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 2.202e-198 633.0
HKD2_k127_7339156_1 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 425.0
HKD2_k127_7339156_2 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000001656 219.0
HKD2_k127_7339156_3 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.0000000000000000000000000000000000000000000000003001 192.0
HKD2_k127_7339156_4 lactoylglutathione lyase activity - - - 0.000000000000000000000000000005604 130.0
HKD2_k127_7339156_5 Putative glycolipid-binding K09957 - - 0.0000000000000000000000009235 109.0
HKD2_k127_7339156_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000005854 107.0
HKD2_k127_7339156_7 Putative glycolipid-binding K09957 - - 0.0000000003991 60.0
HKD2_k127_7341932_0 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 583.0
HKD2_k127_7341932_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 514.0
HKD2_k127_7341932_2 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003521 249.0
HKD2_k127_7341932_3 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000005813 199.0
HKD2_k127_7341932_4 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000002748 201.0
HKD2_k127_7341932_5 helix_turn_helix ASNC type K03719 - - 0.0000000000000000004922 94.0
HKD2_k127_7341932_6 Heat shock protein DnaJ domain protein - - - 0.0000000000000002883 87.0
HKD2_k127_7350978_0 PA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 553.0
HKD2_k127_7350978_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000002123 215.0
HKD2_k127_7397786_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 296.0
HKD2_k127_7397786_1 PFAM AMP-dependent synthetase and ligase - - - 0.00000000005533 75.0
HKD2_k127_7424677_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 3.104e-199 646.0
HKD2_k127_7424677_1 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000001374 173.0
HKD2_k127_7424677_2 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000005133 121.0
HKD2_k127_7424677_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000001431 85.0
HKD2_k127_7424677_4 - - - - 0.00002129 53.0
HKD2_k127_744400_0 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 353.0
HKD2_k127_744400_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 322.0
HKD2_k127_744400_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 327.0
HKD2_k127_744400_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 323.0
HKD2_k127_744400_4 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000005274 207.0
HKD2_k127_744400_5 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000002006 143.0
HKD2_k127_744400_6 CAAX protease self-immunity K07052 - - 0.000004854 56.0
HKD2_k127_7493057_0 PFAM Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 561.0
HKD2_k127_7493057_1 Short chain fatty acid transporter K02106 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 405.0
HKD2_k127_7493057_2 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 303.0
HKD2_k127_7510982_0 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009079 400.0
HKD2_k127_7510982_1 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 366.0
HKD2_k127_7510982_10 TIGRFAM membrane complex biogenesis protein, BtpA family K06971 - - 0.000000000000000000000000000000002378 136.0
HKD2_k127_7510982_11 Regulatory protein - - - 0.000000000000000000001432 98.0
HKD2_k127_7510982_12 acylphosphatase activity K01512 - 3.6.1.7 0.0000000000000008993 81.0
HKD2_k127_7510982_13 - - - - 0.0000003772 53.0
HKD2_k127_7510982_2 decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 353.0
HKD2_k127_7510982_3 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 342.0
HKD2_k127_7510982_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008716 313.0
HKD2_k127_7510982_5 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000004188 243.0
HKD2_k127_7510982_6 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000009302 234.0
HKD2_k127_7510982_7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000003976 227.0
HKD2_k127_7510982_8 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000005661 225.0
HKD2_k127_7510982_9 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000004125 155.0
HKD2_k127_7519765_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 557.0
HKD2_k127_7519765_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001485 252.0
HKD2_k127_7519765_2 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000001843 244.0
HKD2_k127_7519765_3 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000001899 206.0
HKD2_k127_7519765_4 Alpha/beta hydrolase family K07020 - - 0.00000000000000000000000000000000000000000003184 169.0
HKD2_k127_7527984_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1481.0
HKD2_k127_7527984_1 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 460.0
HKD2_k127_7527984_10 Protein of unknown function (DUF2721) - - - 0.00000003637 66.0
HKD2_k127_7527984_11 Protein tyrosine kinase K12132 - 2.7.11.1 0.0005062 51.0
HKD2_k127_7527984_2 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 373.0
HKD2_k127_7527984_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 364.0
HKD2_k127_7527984_4 Outer membrane efflux protein K15725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007021 347.0
HKD2_k127_7527984_5 Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 308.0
HKD2_k127_7527984_6 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005489 294.0
HKD2_k127_7527984_7 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007249 294.0
HKD2_k127_7527984_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000001118 211.0
HKD2_k127_7527984_9 protein kinase activity - - - 0.000000000003269 77.0
HKD2_k127_7528081_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 405.0
HKD2_k127_7528081_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000002789 268.0
HKD2_k127_7528081_2 response regulator receiver K07668 - - 0.00000000000000000000000000000000000000000000000000000000000000002201 230.0
HKD2_k127_7528081_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000001276 177.0
HKD2_k127_7528081_4 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000001061 96.0
HKD2_k127_7540329_0 Sortilin, neurotensin receptor 3, - - - 0.0 1115.0
HKD2_k127_7540329_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000000001674 221.0
HKD2_k127_7540329_2 PAS domain K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000006778 216.0
HKD2_k127_7540329_3 Tetratricopeptide repeat - - - 0.00008969 51.0
HKD2_k127_7560690_0 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 315.0
HKD2_k127_7560690_1 nerve growth factor signaling pathway K15503,K21440 - - 0.000000000000000000000000000000000000002808 160.0
HKD2_k127_7560690_2 Evidence 4 Homologs of previously reported genes of K21440 - - 0.000000000000000004136 98.0
HKD2_k127_7560690_3 serine threonine protein kinase K08282,K08884,K12132 - 2.7.11.1 0.000000000001368 78.0
HKD2_k127_7573969_0 Histidine kinase K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001042 274.0
HKD2_k127_7573969_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000001548 76.0
HKD2_k127_7612483_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 1.453e-232 749.0
HKD2_k127_7612483_1 aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 500.0
HKD2_k127_7612483_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 294.0
HKD2_k127_7612483_3 CBS domain K03699 - - 0.0000000000000000000000000000000000000000000000000000006328 207.0
HKD2_k127_7612483_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000002337 189.0
HKD2_k127_7612483_5 - - - - 0.0000000000000000000000000000000000001878 148.0
HKD2_k127_761674_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 461.0
HKD2_k127_761674_1 POT family K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000003155 235.0
HKD2_k127_761674_2 - K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000003297 187.0
HKD2_k127_761674_3 Domain of unknown function (DUF2383) - - - 0.0000000000000000000000006948 110.0
HKD2_k127_7625048_0 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 317.0
HKD2_k127_7625048_1 MMPL family K07003 - - 0.000000000000000000000000000000001945 136.0
HKD2_k127_7625048_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000002779 108.0
HKD2_k127_7627228_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 479.0
HKD2_k127_7627228_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K01665 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008706 362.0
HKD2_k127_7627228_2 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000004 246.0
HKD2_k127_7627228_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000006656 241.0
HKD2_k127_7627228_4 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000002945 220.0
HKD2_k127_7627228_5 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000003149 189.0
HKD2_k127_7627228_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000003474 159.0
HKD2_k127_7633322_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 460.0
HKD2_k127_7633322_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000006709 207.0
HKD2_k127_7633322_2 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000009535 170.0
HKD2_k127_7651321_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 338.0
HKD2_k127_7651321_1 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000004985 224.0
HKD2_k127_7656546_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.348e-290 912.0
HKD2_k127_7656546_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 4.826e-274 867.0
HKD2_k127_7656546_10 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000386 208.0
HKD2_k127_7656546_11 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000002804 211.0
HKD2_k127_7656546_12 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000009979 154.0
HKD2_k127_7656546_13 heat shock protein binding K05516 - - 0.00000000000000000000000000001077 134.0
HKD2_k127_7656546_14 - - - - 0.00000000000000000000009306 107.0
HKD2_k127_7656546_15 (FHA) domain - - - 0.0000000000001675 83.0
HKD2_k127_7656546_16 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000506 79.0
HKD2_k127_7656546_17 Cyclic nucleotide-monophosphate binding domain - - - 0.000000001139 66.0
HKD2_k127_7656546_18 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000000001535 71.0
HKD2_k127_7656546_19 cellulose binding - - - 0.000000009774 67.0
HKD2_k127_7656546_2 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 487.0
HKD2_k127_7656546_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 475.0
HKD2_k127_7656546_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 454.0
HKD2_k127_7656546_5 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000746 410.0
HKD2_k127_7656546_6 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 310.0
HKD2_k127_7656546_7 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 315.0
HKD2_k127_7656546_8 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009588 284.0
HKD2_k127_7656546_9 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001553 282.0
HKD2_k127_7656987_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 625.0
HKD2_k127_7656987_1 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004944 494.0
HKD2_k127_7656987_2 3-oxoacid CoA-transferase, a subunit K01027,K01028,K01031,K01034 - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 357.0
HKD2_k127_7656987_3 Coenzyme A transferase K01029 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 292.0
HKD2_k127_7656987_4 TIGRFAM LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 296.0
HKD2_k127_7656987_5 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.00000000000000000000000000000000007827 145.0
HKD2_k127_7656987_6 PFAM Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000003674 121.0
HKD2_k127_7656987_7 - - - - 0.0000000000001899 76.0
HKD2_k127_766847_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 584.0
HKD2_k127_766847_1 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 533.0
HKD2_k127_766847_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 416.0
HKD2_k127_766847_3 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 329.0
HKD2_k127_766847_4 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 311.0
HKD2_k127_766847_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007407 265.0
HKD2_k127_766847_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001369 246.0
HKD2_k127_766847_7 peptidyl-tyrosine sulfation K13992 - - 0.00000000000000000000000000000000000001163 154.0
HKD2_k127_766847_8 COG0666 FOG Ankyrin repeat K06867 - - 0.0000000000000000000000000000000001588 142.0
HKD2_k127_766847_9 - - - - 0.00000000000000000000001296 109.0
HKD2_k127_7670611_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.166e-278 865.0
HKD2_k127_7670611_1 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 491.0
HKD2_k127_7670611_10 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000000000038 96.0
HKD2_k127_7670611_12 - - - - 0.00008545 51.0
HKD2_k127_7670611_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 409.0
HKD2_k127_7670611_3 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 367.0
HKD2_k127_7670611_4 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 293.0
HKD2_k127_7670611_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000252 257.0
HKD2_k127_7670611_6 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000009989 254.0
HKD2_k127_7670611_7 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005224 241.0
HKD2_k127_7670611_8 - - - - 0.0000000000000000000000000000000000000000000004861 171.0
HKD2_k127_7707313_0 Bacterial virulence protein (VirJ) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001215 255.0
HKD2_k127_7707313_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000001609 211.0
HKD2_k127_7707313_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000001336 158.0
HKD2_k127_7707313_3 Predicted membrane protein (DUF2061) - - - 0.00000000000000000000000000000000005361 140.0
HKD2_k127_7732015_0 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 330.0
HKD2_k127_7732015_1 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000001571 215.0
HKD2_k127_7732015_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000411 171.0
HKD2_k127_7732015_3 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.0000000000000000000000000003399 119.0
HKD2_k127_7732015_4 peroxiredoxin activity K03564 - 1.11.1.15 0.00000000000000000000005409 101.0
HKD2_k127_7732015_5 Redoxin K03564 - 1.11.1.15 0.0000000000001811 72.0
HKD2_k127_7739206_0 Belongs to the glycosyl hydrolase 13 family - - - 0.0 1229.0
HKD2_k127_7739206_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 559.0
HKD2_k127_7739206_10 - - - - 0.0000000004794 68.0
HKD2_k127_7739206_11 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.000001972 60.0
HKD2_k127_7739206_2 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 548.0
HKD2_k127_7739206_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 363.0
HKD2_k127_7739206_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000003585 224.0
HKD2_k127_7739206_5 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000003678 235.0
HKD2_k127_7739206_6 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000000001231 203.0
HKD2_k127_7739206_7 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K15257 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000004876 196.0
HKD2_k127_7739206_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000003421 192.0
HKD2_k127_7739206_9 Belongs to the UPF0354 family - - - 0.0000000000000000000000000000000266 141.0
HKD2_k127_7783562_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004826 531.0
HKD2_k127_7783562_1 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009074 393.0
HKD2_k127_7783562_10 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000006939 155.0
HKD2_k127_7783562_11 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000002021 147.0
HKD2_k127_7783562_12 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000003338 150.0
HKD2_k127_7783562_13 - - - - 0.00000000000000000000000000000004322 129.0
HKD2_k127_7783562_14 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000005503 124.0
HKD2_k127_7783562_16 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000001234 110.0
HKD2_k127_7783562_17 PQQ-like domain - - - 0.0000000000000000000001277 111.0
HKD2_k127_7783562_18 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000001009 89.0
HKD2_k127_7783562_19 COG1520 FOG WD40-like repeat - - - 0.00000000000000001344 95.0
HKD2_k127_7783562_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 374.0
HKD2_k127_7783562_3 AIR synthase related protein, N-terminal domain K01933,K11788 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 333.0
HKD2_k127_7783562_4 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008291 317.0
HKD2_k127_7783562_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 282.0
HKD2_k127_7783562_6 transferase activity, transferring glycosyl groups K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004212 276.0
HKD2_k127_7783562_7 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003837 264.0
HKD2_k127_7783562_8 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001985 247.0
HKD2_k127_7783562_9 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000002077 202.0
HKD2_k127_780420_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 419.0
HKD2_k127_780420_1 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000002791 208.0
HKD2_k127_780420_2 beta-lactamase domain protein K06897 - 2.5.1.105 0.0000000000000000000000000000000000000004427 153.0
HKD2_k127_780420_3 PIN domain - - - 0.000000002187 64.0
HKD2_k127_780420_4 SnoaL-like domain - - - 0.000001011 57.0
HKD2_k127_780420_5 Forkhead associated domain - - - 0.000003388 60.0
HKD2_k127_7811008_0 Binding-protein-dependent transport system inner membrane component K02050 - - 6.33e-219 694.0
HKD2_k127_7811008_1 C-terminal AAA-associated domain K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 529.0
HKD2_k127_7811008_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 366.0
HKD2_k127_7811008_3 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 314.0
HKD2_k127_7811008_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005438 298.0
HKD2_k127_7811008_5 Histidine kinase HAMP - - - 0.0000000000000000000000000000000000000000000000000000000431 214.0
HKD2_k127_7811008_6 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000003184 152.0
HKD2_k127_7811008_7 - - - - 0.000006107 49.0
HKD2_k127_7860237_0 Sortilin, neurotensin receptor 3, - - - 0.0 1298.0
HKD2_k127_7860237_1 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 383.0
HKD2_k127_7860237_2 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 299.0
HKD2_k127_7860237_3 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000000000005809 210.0
HKD2_k127_7860237_4 CAAX amino terminal protease family - - - 0.000000000000000000000000000001314 135.0
HKD2_k127_7860237_5 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000000000000000002192 106.0
HKD2_k127_7860237_6 amine dehydrogenase activity - - - 0.0000000001887 73.0
HKD2_k127_7861599_0 domain, Protein K01212,K12287,K20276 - 3.2.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000001347 275.0
HKD2_k127_7861599_1 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000001745 256.0
HKD2_k127_7861599_10 Tetratricopeptide repeat - - - 0.0000007764 61.0
HKD2_k127_7861599_2 PFAM nucleoside H symporter K05820 - - 0.000000000000000000000000000000000000000000000000000000000293 217.0
HKD2_k127_7861599_3 - K12065 - - 0.000000000000000000000000000000000000000000000000000000001051 216.0
HKD2_k127_7861599_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000003876 104.0
HKD2_k127_7861599_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.00000000000000000000005718 108.0
HKD2_k127_7861599_6 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000721 99.0
HKD2_k127_7861599_7 Zinc metalloprotease (Elastase) - - - 0.000000000000003831 89.0
HKD2_k127_7861599_8 RDD family - - - 0.0000000000001466 80.0
HKD2_k127_7861599_9 PrcB C-terminal - - - 0.000000005324 64.0
HKD2_k127_7889832_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 5.031e-278 867.0
HKD2_k127_7889832_1 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 451.0
HKD2_k127_7889832_2 Voltage-dependent anion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 419.0
HKD2_k127_7889832_3 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001185 270.0
HKD2_k127_7889832_4 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000002984 170.0
HKD2_k127_7889832_5 - - - - 0.000000000005629 73.0
HKD2_k127_7906920_0 COG2217 Cation transport ATPase K17686 - 3.6.3.54 1.772e-200 642.0
HKD2_k127_7906920_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005995 556.0
HKD2_k127_7906920_2 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000001424 166.0
HKD2_k127_7906920_3 MbtH-like protein K05375,K09190 - - 0.0000000000000000000000000007445 126.0
HKD2_k127_7918587_0 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain K17736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 356.0
HKD2_k127_7918587_1 Aspartyl protease - - - 0.000000000000000000000000000000000000000000000000000000000009784 235.0
HKD2_k127_7918587_2 Sugar-specific transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000005248 181.0
HKD2_k127_7918587_3 intracellular protease amidase - - - 0.000000000000000000000000000000000000001088 160.0
HKD2_k127_7918587_4 exonuclease activity K16899 - 3.6.4.12 0.0000000000000000001267 104.0
HKD2_k127_7918587_6 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0009868 47.0
HKD2_k127_7958555_0 oligopeptide transporter, OPT family - - - 4.921e-218 695.0
HKD2_k127_7958555_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 4.083e-201 644.0
HKD2_k127_7958555_10 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000003819 109.0
HKD2_k127_7958555_11 PFAM conserved K07027 - - 0.00000000000000000105 97.0
HKD2_k127_7958555_12 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.00000000000000004817 89.0
HKD2_k127_7958555_13 Polymer-forming cytoskeletal - - - 0.00000000000001123 78.0
HKD2_k127_7958555_14 R3H domain protein K06346 - - 0.0000000000001148 78.0
HKD2_k127_7958555_15 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000003868 70.0
HKD2_k127_7958555_16 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000004889 73.0
HKD2_k127_7958555_17 Methyltransferase domain - - - 0.0000001976 62.0
HKD2_k127_7958555_2 PFAM OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 570.0
HKD2_k127_7958555_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 311.0
HKD2_k127_7958555_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 317.0
HKD2_k127_7958555_5 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 301.0
HKD2_k127_7958555_6 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005332 283.0
HKD2_k127_7958555_7 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000002065 249.0
HKD2_k127_7958555_8 PFAM Protein kinase K03413 - - 0.0000000000000000000000000000000000000000000000000001582 211.0
HKD2_k127_7958555_9 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000004488 120.0
HKD2_k127_7965855_0 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000338 311.0
HKD2_k127_7965855_1 ZIP Zinc transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000000000000000000000000001791 244.0
HKD2_k127_7965855_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000003504 205.0
HKD2_k127_7965855_3 carboxylic acid catabolic process - - - 0.0000000000000000000000000000000000000000000000000011 194.0
HKD2_k127_7965855_4 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000004171 143.0
HKD2_k127_7965855_5 Cobalt transport protein K16785,K16786,K16787 - - 0.0000000000000000000000000000000003825 140.0
HKD2_k127_7965855_6 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000002323 132.0
HKD2_k127_7965855_7 Peptidase family M23 K01406 - 3.4.24.40 0.00000000000000000000001323 113.0
HKD2_k127_7965855_8 Belongs to the peptidase S8 family K14645 GO:0005575,GO:0005576 - 0.000000000000004991 91.0
HKD2_k127_7965855_9 Domain of unknown function DUF11 - - - 0.0003711 55.0
HKD2_k127_7974024_0 Domain in cystathionine beta-synthase and other proteins. - - - 2.449e-213 680.0
HKD2_k127_7974024_1 Belongs to the glycosyl hydrolase 13 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 417.0
HKD2_k127_7974024_2 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 302.0
HKD2_k127_7984118_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1238.0
HKD2_k127_7984118_1 Tetratricopeptide repeat K12132 - 2.7.11.1 1.89e-291 951.0
HKD2_k127_7984118_10 hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000003472 186.0
HKD2_k127_7984118_12 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000000000746 141.0
HKD2_k127_7984118_13 - - - - 0.0000000000000000000000000000004398 137.0
HKD2_k127_7984118_14 Protein of unknown function VcgC/VcgE (DUF2780) - - - 0.000000000000000003961 93.0
HKD2_k127_7984118_15 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.000000007294 70.0
HKD2_k127_7984118_16 Protein tyrosine kinase - - - 0.0000002072 61.0
HKD2_k127_7984118_17 BON domain K04065 - - 0.00001301 54.0
HKD2_k127_7984118_18 exo-alpha-(2->6)-sialidase activity K20276 - - 0.0000413 53.0
HKD2_k127_7984118_19 SPFH domain-Band 7 family - - - 0.0007022 50.0
HKD2_k127_7984118_2 glycosyl transferase family K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 1.306e-238 758.0
HKD2_k127_7984118_3 Glucoamylase and related glycosyl hydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 416.0
HKD2_k127_7984118_4 exo-alpha-(2->6)-sialidase activity K01186 GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509 3.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 400.0
HKD2_k127_7984118_5 Biotin-lipoyl like K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 337.0
HKD2_k127_7984118_6 Protein of unknown function, DUF481 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001085 247.0
HKD2_k127_7984118_7 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001157 235.0
HKD2_k127_7984118_8 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000000000001257 239.0
HKD2_k127_7984118_9 PFAM virulence factor family protein - - - 0.000000000000000000000000000000000000000000000000000000000001336 218.0
HKD2_k127_7995403_0 Lysylphosphatidylglycerol synthase TM region K07027,K14205 - 2.3.2.3 2.118e-285 899.0
HKD2_k127_7995403_1 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 407.0
HKD2_k127_7995403_2 PFAM Pyruvate carboxyltransferase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 306.0
HKD2_k127_7995403_3 Domain of unknown function (DUF4037) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006047 270.0
HKD2_k127_7998596_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 489.0
HKD2_k127_7998596_1 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 462.0
HKD2_k127_7998596_2 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 345.0
HKD2_k127_7998596_3 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 315.0
HKD2_k127_7998596_4 PFAM ROK family protein K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000003705 248.0
HKD2_k127_7998596_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000002032 141.0
HKD2_k127_7998596_6 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000001713 125.0
HKD2_k127_8022831_0 radical SAM domain protein K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 422.0
HKD2_k127_8022831_1 Acetyltransferase (GNAT) domain - - - 0.00000000000004836 73.0
HKD2_k127_8022831_2 lysine biosynthetic process via aminoadipic acid - - - 0.0001233 46.0
HKD2_k127_8024663_0 Belongs to the carbamoyltransferase HypF family K04656 - - 2.676e-226 725.0
HKD2_k127_8024663_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 311.0
HKD2_k127_8024663_2 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003488 259.0
HKD2_k127_8024663_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000004962 194.0
HKD2_k127_8024663_4 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000001669 134.0
HKD2_k127_8024663_5 hydrogenase nickel incorporation protein HypA K04651 - - 0.0005426 49.0
HKD2_k127_8024957_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 6.016e-202 639.0
HKD2_k127_8024957_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 561.0
HKD2_k127_8024957_10 inositol monophosphate 1-phosphatase activity K01082,K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000002794 243.0
HKD2_k127_8024957_11 serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000000000000000000000000005864 227.0
HKD2_k127_8024957_12 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000003424 203.0
HKD2_k127_8024957_13 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000002175 203.0
HKD2_k127_8024957_14 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000000000000000000000000000000000000000002628 171.0
HKD2_k127_8024957_15 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.00000000000000000000000000000000000000003037 175.0
HKD2_k127_8024957_16 cell adhesion K02024 - - 0.0000000000000000000000000000007617 138.0
HKD2_k127_8024957_17 Protein of unknown function DUF58 - - - 0.000000000000000000000000004439 124.0
HKD2_k127_8024957_18 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000003586 103.0
HKD2_k127_8024957_19 Domain of unknown function (DUF4412) - - - 0.000000000003026 75.0
HKD2_k127_8024957_2 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 510.0
HKD2_k127_8024957_20 Protein of unknown function (DUF503) K09764 - - 0.00000000005147 65.0
HKD2_k127_8024957_21 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000001378 64.0
HKD2_k127_8024957_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 347.0
HKD2_k127_8024957_4 Protein of unknown function DUF111 K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006944 301.0
HKD2_k127_8024957_5 Transglutaminase-like superfamily K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000003758 289.0
HKD2_k127_8024957_6 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002325 273.0
HKD2_k127_8024957_7 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001367 259.0
HKD2_k127_8024957_8 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000004066 248.0
HKD2_k127_8024957_9 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000518 251.0
HKD2_k127_8029255_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.043e-273 859.0
HKD2_k127_8029255_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000006013 111.0
HKD2_k127_8029255_2 PFAM glycosyl transferase group 1 - - - 0.0004458 49.0
HKD2_k127_8040400_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1384.0
HKD2_k127_8040400_1 arylsulfatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 306.0
HKD2_k127_8040400_2 peptide-methionine (S)-S-oxide reductase activity K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001321 282.0
HKD2_k127_8040400_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001741 288.0
HKD2_k127_8040400_4 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000004287 73.0
HKD2_k127_8040400_5 - - - - 0.000004083 57.0
HKD2_k127_8056974_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 8.123e-243 763.0
HKD2_k127_8056974_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006648 618.0
HKD2_k127_8056974_10 gliding motility-associated C-terminal domain - - - 0.00004859 58.0
HKD2_k127_8056974_11 - - - - 0.0003245 49.0
HKD2_k127_8056974_12 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0004765 53.0
HKD2_k127_8056974_13 membrane - - - 0.000628 53.0
HKD2_k127_8056974_2 Peptidase dimerisation domain K12941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 535.0
HKD2_k127_8056974_3 Alcohol dehydrogenase GroES-like domain K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 526.0
HKD2_k127_8056974_4 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 521.0
HKD2_k127_8056974_5 Pkd domain containing protein K12567 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 373.0
HKD2_k127_8056974_6 Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009893,GO:0009987,GO:0019216,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045828,GO:0045834,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:0080090,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002037 271.0
HKD2_k127_8056974_7 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000005332 204.0
HKD2_k127_8056974_8 Cadherin-like beta sandwich domain - - - 0.00000000000000000000000000000000000000000000000000001098 218.0
HKD2_k127_8056974_9 - - - - 0.000000000000000000000004092 111.0
HKD2_k127_8095012_0 PFAM Methanol-cobalamin methyltransferase B subunit K04480 - 2.1.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 600.0
HKD2_k127_8095012_1 - Amino acid transport and metabolism K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 383.0
HKD2_k127_8095012_2 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 337.0
HKD2_k127_8095012_3 cobalamin binding protein K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000003211 245.0
HKD2_k127_8095012_4 competence protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003415 256.0
HKD2_k127_8095012_5 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K01802,K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000001873 229.0
HKD2_k127_8095012_7 Nodulation protein S (NodS) - - - 0.000000000295 70.0
HKD2_k127_8095012_8 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000002453 61.0
HKD2_k127_8127408_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 1.484e-211 675.0
HKD2_k127_8127408_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 504.0
HKD2_k127_8139620_0 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 535.0
HKD2_k127_8139620_1 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000001795 217.0
HKD2_k127_8150130_0 PFAM peptidase T2 asparaginase 2 K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 384.0
HKD2_k127_8150130_1 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 315.0
HKD2_k127_8150130_2 PFAM peptidase M16 domain protein K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 323.0
HKD2_k127_8150130_3 converts alpha-aldose to the beta-anomer - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003272 268.0
HKD2_k127_8150130_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000002905 168.0
HKD2_k127_8150130_5 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000003128 55.0
HKD2_k127_8156784_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 465.0
HKD2_k127_8156784_1 TIGRFAM Por secretion system C-terminal sorting domain - - - 0.000000000000000000000000000009141 132.0
HKD2_k127_8156784_2 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000008927 97.0
HKD2_k127_8170542_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 6.268e-237 760.0
HKD2_k127_8170572_0 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 528.0
HKD2_k127_8170572_1 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 449.0
HKD2_k127_8170572_2 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 387.0
HKD2_k127_8170572_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001328 282.0
HKD2_k127_8170572_4 - - - - 0.0000000000000000000000000000000000000000000000000000000007346 213.0
HKD2_k127_8170572_5 Thioredoxin - - - 0.000000000000001291 88.0
HKD2_k127_817208_0 Lipase maturation factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 431.0
HKD2_k127_817208_1 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 320.0
HKD2_k127_817208_2 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000004762 138.0
HKD2_k127_817208_3 response regulator - - - 0.00000000000000000000000000000000007712 143.0
HKD2_k127_817208_4 Polysaccharide biosynthesis protein - - - 0.00000000000000000000003614 115.0
HKD2_k127_8173941_0 cellulose binding - - - 1.961e-255 819.0
HKD2_k127_8173941_1 WbqC-like protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002507 285.0
HKD2_k127_8173941_2 TIGRFAM Diguanylate cyclase - - - 0.00000000000000000000000000000003995 145.0
HKD2_k127_8173941_3 - - - - 0.00001467 57.0
HKD2_k127_8177928_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 490.0
HKD2_k127_8177928_1 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 338.0
HKD2_k127_8177928_2 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.00000000000000000000000000000000000000000000000000001888 196.0
HKD2_k127_8179568_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00316 - 1.5.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 602.0
HKD2_k127_8179568_1 Oligopeptidase F K08602 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 582.0
HKD2_k127_8179568_2 Protoporphyrinogen oxidase - - - 0.000000008631 57.0
HKD2_k127_8228900_0 Domain of unknown function (DUF1998) K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 1.845e-275 869.0
HKD2_k127_8228900_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000001132 272.0
HKD2_k127_8228900_2 protein-disulfide reductase activity - - - 0.000000000000000003903 94.0
HKD2_k127_8255329_0 ADP-glyceromanno-heptose 6-epimerase activity K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 486.0
HKD2_k127_8255329_1 S-adenosylhomocysteine deaminase activity K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000228 280.0
HKD2_k127_8255329_10 PFAM PEGA domain - - - 0.00007052 55.0
HKD2_k127_8255329_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000001387 272.0
HKD2_k127_8255329_3 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000001829 153.0
HKD2_k127_8255329_4 ethanolamine catabolic process K04027 - - 0.000000000000000000000000000000000009683 147.0
HKD2_k127_8255329_5 Ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000000001834 99.0
HKD2_k127_8255329_6 Ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.000000000000000000001933 98.0
HKD2_k127_8255329_7 thiolester hydrolase activity K06889 - - 0.00000000000000000002212 102.0
HKD2_k127_8255329_8 Ethanolamine utilisation protein EutN/carboxysome - - - 0.0000000000000000001845 94.0
HKD2_k127_8255329_9 Belongs to the ClpA ClpB family K03695,K03696 - - 0.00000000000001875 78.0
HKD2_k127_8262577_0 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 366.0
HKD2_k127_8262577_1 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 344.0
HKD2_k127_8262577_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 347.0
HKD2_k127_8262577_3 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000003666 274.0
HKD2_k127_8262577_4 tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000002407 184.0
HKD2_k127_8262577_5 Diguanylate cyclase with GAF sensor - - - 0.000000000000000000000000000000000000000000000005098 191.0
HKD2_k127_8262577_6 Heat shock protein DnaJ domain protein - - - 0.0000000000001468 82.0
HKD2_k127_8262577_7 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000001348 59.0
HKD2_k127_8262577_8 Mitochondrial K+-H+ exchange-related - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006839,GO:0008150,GO:0009987,GO:0015672,GO:0016020,GO:0016021,GO:0019866,GO:0030001,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031975,GO:0032592,GO:0034220,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098573,GO:0098655,GO:0098660,GO:0098662,GO:0140141,GO:1990542 - 0.00001941 55.0
HKD2_k127_8311003_0 gluconolactonase activity K01053 - 3.1.1.17 1.998e-210 666.0
HKD2_k127_8311003_1 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 511.0
HKD2_k127_8311003_2 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 341.0
HKD2_k127_8311003_3 Cupin 2, conserved barrel domain protein K11477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 315.0
HKD2_k127_8311003_4 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 316.0
HKD2_k127_8311003_5 Transport and Golgi organisation 2 K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 305.0
HKD2_k127_8311003_6 monooxygenase activity - - - 0.0000000000000000000000000000000000000000000001502 172.0
HKD2_k127_8311003_7 DoxX-like family - - - 0.0000000000000000000000000000000000000003398 153.0
HKD2_k127_8311003_8 Belongs to the glycosyl hydrolase 13 family - - - 0.000000000000006218 88.0
HKD2_k127_8319832_0 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000006165 233.0
HKD2_k127_8319832_1 Stromelysin-3 K07993 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005796,GO:0006508,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0009056,GO:0009987,GO:0012505,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022411,GO:0022617,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0031974,GO:0032501,GO:0032502,GO:0032963,GO:0043062,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044238,GO:0044421,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045596,GO:0045598,GO:0045599,GO:0048519,GO:0048523,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007,GO:0070011,GO:0070013,GO:0071704,GO:0071711,GO:0071840,GO:0097435,GO:0140096,GO:1901564 - 0.0000000005872 71.0
HKD2_k127_8331033_0 DNA ligase K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 479.0
HKD2_k127_8331033_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000002197 208.0
HKD2_k127_8331033_2 diguanylate cyclase K02488 - 2.7.7.65 0.000000000002101 80.0
HKD2_k127_8336253_0 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 457.0
HKD2_k127_8336253_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 406.0
HKD2_k127_8336253_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000002919 201.0
HKD2_k127_8336253_3 - - - - 0.000000000000000000000000006493 126.0
HKD2_k127_8336253_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000005421 75.0
HKD2_k127_8345007_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 609.0
HKD2_k127_8345007_1 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000002752 236.0
HKD2_k127_8345007_2 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000001931 156.0
HKD2_k127_8345007_3 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000003818 143.0
HKD2_k127_8345007_4 Domain of unknown function (DUF4416) - - - 0.000000000000000000000000000000000005017 145.0
HKD2_k127_8345007_5 Tetratricopeptide repeat - - - 0.000000000000000000001113 105.0
HKD2_k127_8345007_6 Roadblock/LC7 domain - - - 0.000000000008764 70.0
HKD2_k127_8345007_7 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000001587 63.0
HKD2_k127_8345007_8 Tetratricopeptide repeat - - - 0.0000000003429 72.0
HKD2_k127_8372256_0 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008984 347.0
HKD2_k127_8372256_1 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 331.0
HKD2_k127_8372256_2 Bacterial membrane protein, YfhO - - - 0.0000000000000000000000000004779 133.0
HKD2_k127_8372256_3 peptidase S58, DmpA - - - 0.0000005522 59.0
HKD2_k127_8372256_4 Bacterial membrane protein YfhO - - - 0.00007916 57.0
HKD2_k127_8394434_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1330.0
HKD2_k127_8394434_1 cAMP biosynthetic process K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 318.0
HKD2_k127_8394434_2 Drug metabolite transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009423 282.0
HKD2_k127_8394434_3 - - - - 0.00000000000000000002293 96.0
HKD2_k127_8394434_4 Mitochondrial small ribosomal subunit Rsm22 - - - 0.00000003783 65.0
HKD2_k127_8410939_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008331 510.0
HKD2_k127_8410939_1 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 449.0
HKD2_k127_8410939_10 Putative regulatory protein - - - 0.000000001225 62.0
HKD2_k127_8410939_2 PFAM Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 311.0
HKD2_k127_8410939_3 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007372 287.0
HKD2_k127_8410939_4 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000000000000002414 228.0
HKD2_k127_8410939_5 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000003504 220.0
HKD2_k127_8410939_6 - - - - 0.0000000000000000000000000000000000000000000000000002407 194.0
HKD2_k127_8410939_7 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000008809 196.0
HKD2_k127_8410939_8 Thioesterase K07107 - - 0.0000000000000000000000000006093 121.0
HKD2_k127_8410939_9 E-Z type HEAT repeats - - - 0.00000000000000000000000006253 120.0
HKD2_k127_8413226_0 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000006398 248.0
HKD2_k127_8413226_1 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000004233 248.0
HKD2_k127_8413226_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000004234 179.0
HKD2_k127_8413226_3 Membrane - - - 0.00000000000000000000000000000000000000000000153 188.0
HKD2_k127_8430073_0 - - - - 0.0000000000000000000000000000000000000000000008349 178.0
HKD2_k127_8430073_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000002011 144.0
HKD2_k127_8430073_2 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.00000000002458 77.0
HKD2_k127_8430597_0 FtsX-like permease family K02004 - - 7.042e-231 741.0
HKD2_k127_8430597_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 352.0
HKD2_k127_8430597_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 307.0
HKD2_k127_8430597_3 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000003855 264.0
HKD2_k127_8430597_4 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003266 272.0
HKD2_k127_8430597_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000005087 192.0
HKD2_k127_8430597_6 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000006204 183.0
HKD2_k127_8442864_0 Large extracellular alpha-helical protein K06894 - - 3.061e-251 812.0
HKD2_k127_8444685_0 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 369.0
HKD2_k127_8444685_1 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 349.0
HKD2_k127_8444685_3 ECF sigma factor K03088 - - 0.0000000000000000000000000000000005396 139.0
HKD2_k127_8444685_4 Protein of unknown function (DUF3106) - - - 0.00000000000002737 80.0
HKD2_k127_8444685_5 bacterial-type flagellum-dependent cell motility K02396,K13276 - - 0.00000000000009551 83.0
HKD2_k127_8444685_6 Putative zinc-finger - - - 0.0001615 51.0
HKD2_k127_8444685_7 Protein kinase domain K12132 - 2.7.11.1 0.0008324 47.0
HKD2_k127_8466736_0 mannose-ethanolamine phosphotransferase activity K01077 GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 332.0
HKD2_k127_8466736_1 Amino acid permease K20265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000369 296.0
HKD2_k127_8466736_2 DNA ligase D, 3'-phosphoesterase domain K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000001565 199.0
HKD2_k127_8466736_3 PKD domain containing protein K01183 - 3.2.1.14 0.000000000000000000000000000001007 136.0
HKD2_k127_8466736_4 long-chain fatty acid transport protein K06076 - - 0.000000000003537 79.0
HKD2_k127_8466736_5 - - - - 0.00000001249 59.0
HKD2_k127_8466736_6 Penicillinase repressor - - - 0.000001604 54.0
HKD2_k127_8471924_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 578.0
HKD2_k127_8471924_1 sigma-54 factor interaction domain-containing protein - - - 0.00000136 50.0
HKD2_k127_8476777_0 ammonia-lyase activity K01745 - 4.3.1.3 4.327e-264 820.0
HKD2_k127_8476777_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 406.0
HKD2_k127_8476777_2 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007583 287.0
HKD2_k127_8490521_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006621 415.0
HKD2_k127_8490521_1 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000003278 222.0
HKD2_k127_8490521_2 Histidine kinase K02668,K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001417 222.0
HKD2_k127_8490521_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000001228 176.0
HKD2_k127_8490521_4 Belongs to the 'phage' integrase family - - - 0.0000000009289 61.0
HKD2_k127_8504724_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 8.622e-248 786.0
HKD2_k127_8504724_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 404.0
HKD2_k127_8504724_10 histone H2A K63-linked ubiquitination K10914 - - 0.000000000000000000000000000000000000001999 156.0
HKD2_k127_8504724_11 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.00000000000000000000000000000000000165 148.0
HKD2_k127_8504724_12 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000000009524 138.0
HKD2_k127_8504724_13 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000000000000000008648 131.0
HKD2_k127_8504724_14 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000002138 120.0
HKD2_k127_8504724_15 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000000000000000002254 95.0
HKD2_k127_8504724_16 Protein of unknown function (DUF465) K09794 - - 0.00000003902 57.0
HKD2_k127_8504724_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 378.0
HKD2_k127_8504724_3 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 308.0
HKD2_k127_8504724_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001085 280.0
HKD2_k127_8504724_5 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000001437 247.0
HKD2_k127_8504724_6 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000002104 213.0
HKD2_k127_8504724_7 chromosome segregation K03497 - - 0.000000000000000000000000000000000000000000000000000000000006241 218.0
HKD2_k127_8504724_8 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000002732 197.0
HKD2_k127_8504724_9 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000001238 199.0
HKD2_k127_8505082_0 Domain of unknown function (DUF4416) - - - 0.000000000000000000000000000000000000122 148.0
HKD2_k127_8505082_1 arylamine N-acetyltransferase activity - - - 0.0000000000000000000000000003161 128.0
HKD2_k127_8505082_2 Putative diguanylate phosphodiesterase - - - 0.000007562 48.0
HKD2_k127_8505082_3 Y_Y_Y domain - - - 0.0001994 54.0
HKD2_k127_8522663_0 PFAM Forkhead-associated protein - - - 0.00000000000000000000000000000000000000000000000000000000000000007058 251.0
HKD2_k127_8522663_1 Putative metallopeptidase - - - 0.000000000000000000000000000000000000000000000006196 180.0
HKD2_k127_8522663_2 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000001522 146.0
HKD2_k127_8522663_3 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0002127 46.0
HKD2_k127_8531957_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0022900,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:1902494 1.12.99.6 1.455e-309 955.0
HKD2_k127_8531957_1 oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor K06282 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009634 497.0
HKD2_k127_8531957_2 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 381.0
HKD2_k127_8531957_3 spore germination K03605 - - 0.0000000000000000000000000000000000000002195 157.0
HKD2_k127_8531957_4 SnoaL-like polyketide cyclase - - - 0.0000000000000000001011 94.0
HKD2_k127_8534279_0 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000325 305.0
HKD2_k127_8534279_1 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000009666 224.0
HKD2_k127_8534279_2 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000001923 163.0
HKD2_k127_8534279_3 - - - - 0.00000000000000000000000005336 114.0
HKD2_k127_8537084_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 9.16e-244 777.0
HKD2_k127_8537084_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 498.0
HKD2_k127_8537084_2 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000553 288.0
HKD2_k127_8537084_3 Tetratricopeptide repeat K20543 - - 0.00000000000000000000000000004027 128.0
HKD2_k127_8550660_0 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 593.0
HKD2_k127_8550660_1 DNA topoisomerase II activity K03167 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 467.0
HKD2_k127_8550660_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530,K05787 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990104,GO:1990178,GO:2001141 - 0.0000000000000000000000001384 108.0
HKD2_k127_8565027_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.132,1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 544.0
HKD2_k127_8565027_1 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 443.0
HKD2_k127_8565027_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 367.0
HKD2_k127_8565027_3 PFAM UvrB UvrC protein AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2 K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 293.0
HKD2_k127_8565027_4 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000002137 215.0
HKD2_k127_8565027_5 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000604 105.0
HKD2_k127_858279_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 378.0
HKD2_k127_858279_1 transferase activity, transferring glycosyl groups K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 331.0
HKD2_k127_858279_2 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000004362 235.0
HKD2_k127_8623797_0 Amidohydrolase family K06015 - 3.5.1.81 4.275e-251 786.0
HKD2_k127_8623797_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000002632 129.0
HKD2_k127_8637537_0 Phosphotransferase enzyme family - - - 1.314e-279 883.0
HKD2_k127_8637537_1 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 557.0
HKD2_k127_8637537_2 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity K01954,K01955,K03660,K11540,K11541,K19656 GO:0000050,GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003922,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0004518,GO:0004519,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006142,GO:0006206,GO:0006207,GO:0006220,GO:0006244,GO:0006259,GO:0006281,GO:0006282,GO:0006284,GO:0006285,GO:0006289,GO:0006304,GO:0006355,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0008652,GO:0009056,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009166,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009889,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010605,GO:0016020,GO:0016021,GO:0016053,GO:0016363,GO:0016604,GO:0016607,GO:0016740,GO:0016741,GO:0016743,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019627,GO:0019637,GO:0019692,GO:0019752,GO:0019856,GO:0031224,GO:0031323,GO:0031324,GO:0031326,GO:0031974,GO:0031981,GO:0032356,GO:0032357,GO:0032991,GO:0033554,GO:0033683,GO:0034399,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045007,GO:0045008,GO:0045738,GO:0045934,GO:0045984,GO:0046112,GO:0046386,GO:0046394,GO:0046434,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0051716,GO:0055086,GO:0060255,GO:0062012,GO:0062014,GO:0065007,GO:0070013,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0072529,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901135,GO:1901136,GO:1901291,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903506,GO:2000112,GO:2000779,GO:2000780,GO:2001020,GO:2001021,GO:2001141 2.1.3.2,3.5.2.3,4.2.99.18,6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 411.0
HKD2_k127_8637537_3 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 292.0
HKD2_k127_8637537_4 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000001226 235.0
HKD2_k127_8651134_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2.689e-195 621.0
HKD2_k127_8651134_1 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000001624 154.0
HKD2_k127_8651134_2 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.00000000000000000000000000000002985 132.0
HKD2_k127_8651134_3 - - - - 0.00000000001261 65.0
HKD2_k127_8651134_4 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000003769 61.0
HKD2_k127_8651134_5 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00005352 53.0
HKD2_k127_8651316_0 Sulfate permease family K03321 - - 3.924e-236 745.0
HKD2_k127_8651316_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 611.0
HKD2_k127_8651316_10 7TM diverse intracellular signalling K20971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 319.0
HKD2_k127_8651316_11 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003186 283.0
HKD2_k127_8651316_12 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008319 271.0
HKD2_k127_8651316_14 Glycosyl transferase family group 2 K12994 - 2.4.1.349 0.0000000000000000000000000000000000000000000000000000000000000006212 231.0
HKD2_k127_8651316_15 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000691 229.0
HKD2_k127_8651316_16 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000003215 209.0
HKD2_k127_8651316_17 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000006118 190.0
HKD2_k127_8651316_18 PFAM GCN5-related N-acetyltransferase K03825 - - 0.0000000000000000000000000000000000000000000000006097 181.0
HKD2_k127_8651316_19 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000003671 173.0
HKD2_k127_8651316_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 554.0
HKD2_k127_8651316_20 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000003368 154.0
HKD2_k127_8651316_21 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.00000000000000000000000000000000000008346 161.0
HKD2_k127_8651316_22 4-amino-4-deoxy-L-arabinose transferase activity K02277 - 1.9.3.1 0.0000000000000000000000000000002426 141.0
HKD2_k127_8651316_23 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000005992 115.0
HKD2_k127_8651316_24 Autotransporter beta-domain - - - 0.00000000000000008443 91.0
HKD2_k127_8651316_26 - - - - 0.00000006332 62.0
HKD2_k127_8651316_27 Bacterial membrane protein YfhO - - - 0.00003874 57.0
HKD2_k127_8651316_28 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0006135 52.0
HKD2_k127_8651316_3 TIGRFAM cysteine desulfurase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 509.0
HKD2_k127_8651316_4 COG0659 Sulfate permease and related transporters (MFS superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 490.0
HKD2_k127_8651316_5 Kelch motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 513.0
HKD2_k127_8651316_6 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 432.0
HKD2_k127_8651316_7 PFAM beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 429.0
HKD2_k127_8651316_8 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 342.0
HKD2_k127_8651316_9 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 303.0
HKD2_k127_8660930_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.894e-315 977.0
HKD2_k127_8660930_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 6.859e-203 637.0
HKD2_k127_8660930_10 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
HKD2_k127_8660930_11 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000281 269.0
HKD2_k127_8660930_12 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002455 263.0
HKD2_k127_8660930_13 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000004737 252.0
HKD2_k127_8660930_14 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000344 219.0
HKD2_k127_8660930_15 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000684 218.0
HKD2_k127_8660930_16 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000004883 213.0
HKD2_k127_8660930_17 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001022 210.0
HKD2_k127_8660930_18 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000001077 220.0
HKD2_k127_8660930_19 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000002509 206.0
HKD2_k127_8660930_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 614.0
HKD2_k127_8660930_20 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000002779 204.0
HKD2_k127_8660930_21 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.0000000000000000000000000000000000000000000000000000003744 202.0
HKD2_k127_8660930_22 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000009301 194.0
HKD2_k127_8660930_23 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000000000009488 191.0
HKD2_k127_8660930_24 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000001762 182.0
HKD2_k127_8660930_25 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000002335 186.0
HKD2_k127_8660930_26 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000593 173.0
HKD2_k127_8660930_27 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000003612 170.0
HKD2_k127_8660930_28 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000004123 169.0
HKD2_k127_8660930_29 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000006119 167.0
HKD2_k127_8660930_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 418.0
HKD2_k127_8660930_30 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000002449 151.0
HKD2_k127_8660930_31 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000007597 137.0
HKD2_k127_8660930_32 - - - - 0.0000000000000000000000000000000001939 149.0
HKD2_k127_8660930_33 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000000009527 121.0
HKD2_k127_8660930_34 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000001452 117.0
HKD2_k127_8660930_35 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000007575 110.0
HKD2_k127_8660930_36 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000002327 111.0
HKD2_k127_8660930_37 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000001514 106.0
HKD2_k127_8660930_38 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000001402 100.0
HKD2_k127_8660930_39 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000001181 97.0
HKD2_k127_8660930_4 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008892 418.0
HKD2_k127_8660930_40 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000004053 68.0
HKD2_k127_8660930_41 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000007392 66.0
HKD2_k127_8660930_42 50S ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000001644 67.0
HKD2_k127_8660930_5 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008548 358.0
HKD2_k127_8660930_6 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 347.0
HKD2_k127_8660930_7 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 317.0
HKD2_k127_8660930_8 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 326.0
HKD2_k127_8660930_9 Abc transporter K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 304.0
HKD2_k127_8695330_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 2.187e-236 765.0
HKD2_k127_8695330_1 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 7.959e-226 710.0
HKD2_k127_8695330_10 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001091 274.0
HKD2_k127_8695330_11 amine dehydrogenase activity K14647,K21449 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002215 276.0
HKD2_k127_8695330_12 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000006334 258.0
HKD2_k127_8695330_13 - - - - 0.0000000000000000000000000000000000000000000003581 171.0
HKD2_k127_8695330_14 protein conserved in bacteria K09931 - - 0.0000000000000000000000000000000000001146 149.0
HKD2_k127_8695330_15 Belongs to the UPF0761 family K07058 - - 0.000000000000000000000000000000006413 139.0
HKD2_k127_8695330_16 Glycosyl transferase, family 2 K00721,K01912,K08301 - 2.4.1.83,6.2.1.30 0.00000000000000000000000000000001002 141.0
HKD2_k127_8695330_17 PFAM Methyltransferase type 11 - - - 0.0000000000000000123 95.0
HKD2_k127_8695330_18 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000004116 89.0
HKD2_k127_8695330_19 Peptidase C13 family - - - 0.0001342 53.0
HKD2_k127_8695330_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 620.0
HKD2_k127_8695330_3 AAA ATPase, central domain protein K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 535.0
HKD2_k127_8695330_4 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 491.0
HKD2_k127_8695330_5 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 436.0
HKD2_k127_8695330_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 392.0
HKD2_k127_8695330_7 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 381.0
HKD2_k127_8695330_8 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 363.0
HKD2_k127_8695330_9 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 331.0
HKD2_k127_8703868_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007492 596.0
HKD2_k127_8703868_1 Domain of unknown function (DUF2437) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004904 260.0
HKD2_k127_8703868_2 Proteasome subunit K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000005011 243.0
HKD2_k127_8703868_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000001259 239.0
HKD2_k127_8703868_4 CarD-like/TRCF domain K07736 - - 0.000000000000000000000000000000000000006768 151.0
HKD2_k127_8703868_5 Fibronectin type 3 domain - - - 0.0000000306 66.0
HKD2_k127_8713332_0 Putative diguanylate phosphodiesterase - - - 3.964e-221 722.0
HKD2_k127_8713332_1 - - - - 0.0001607 54.0
HKD2_k127_8715540_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 490.0
HKD2_k127_8715540_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 325.0
HKD2_k127_8715540_2 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 305.0
HKD2_k127_8715540_3 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.00000000000000000000000000000000000000000000001677 176.0
HKD2_k127_8715540_4 protein kinase activity - - - 0.000000000000000000002172 109.0
HKD2_k127_8715540_5 - - - - 0.0000000000000003206 80.0
HKD2_k127_8721048_0 Voltage gated chloride channel - - - 3.046e-222 704.0
HKD2_k127_8721048_1 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 546.0
HKD2_k127_8721048_10 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000003179 132.0
HKD2_k127_8721048_11 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000006829 94.0
HKD2_k127_8721048_2 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003954 261.0
HKD2_k127_8721048_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000005088 226.0
HKD2_k127_8721048_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000006881 226.0
HKD2_k127_8721048_5 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000001286 216.0
HKD2_k127_8721048_6 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000001699 211.0
HKD2_k127_8721048_7 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000001691 184.0
HKD2_k127_8721048_8 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000388 153.0
HKD2_k127_8721048_9 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000008673 143.0
HKD2_k127_8728255_0 PFAM magnesium chelatase K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 521.0
HKD2_k127_8728255_1 TIGRFAM acetaldehyde dehydrogenase (acetylating) K00132 - 1.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 464.0
HKD2_k127_8728255_11 - - - - 0.00000002255 59.0
HKD2_k127_8728255_2 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 412.0
HKD2_k127_8728255_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 345.0
HKD2_k127_8728255_4 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000001507 167.0
HKD2_k127_8728255_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000007131 166.0
HKD2_k127_8728255_6 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000001626 152.0
HKD2_k127_8728255_7 BMC - - - 0.00000000000000000000000000000000002363 138.0
HKD2_k127_8728255_9 4-amino-4-deoxy-L-arabinose transferase activity K07264 - 2.4.2.43 0.000000000000000000000000003744 126.0
HKD2_k127_8742255_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.219e-247 783.0
HKD2_k127_8742255_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002035 263.0
HKD2_k127_8742255_2 Domain of unknown function (DUF4034) - - - 0.0000008978 54.0
HKD2_k127_8789101_0 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 490.0
HKD2_k127_8789101_1 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001908 280.0
HKD2_k127_8789101_2 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000006481 219.0
HKD2_k127_8789101_3 DinB superfamily - - - 0.00000000000000000000000001527 116.0
HKD2_k127_8789101_4 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000001812 54.0
HKD2_k127_8806744_0 amino acid peptide transporter K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 459.0
HKD2_k127_8806744_1 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000000000000000000000005109 219.0
HKD2_k127_8806744_2 PFAM Dual specificity protein phosphatase K14165 - 3.1.3.16,3.1.3.48 0.000000000000000002432 91.0
HKD2_k127_8842003_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006296 285.0
HKD2_k127_8842003_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000001368 213.0
HKD2_k127_8904590_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1007.0
HKD2_k127_8904590_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 2.954e-258 807.0
HKD2_k127_8904590_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000008207 247.0
HKD2_k127_8904590_3 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000005847 201.0
HKD2_k127_8904590_4 - - - - 0.0000000000000000000000000000001199 127.0
HKD2_k127_8904590_5 Parallel beta-helix repeats - - - 0.00000001822 63.0
HKD2_k127_8911137_0 Oxidoreductase - - - 1.566e-271 843.0
HKD2_k127_8911137_1 Glycine cleavage T-protein C-terminal barrel domain - - - 1.175e-202 636.0
HKD2_k127_8911137_2 Thi4 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 594.0
HKD2_k127_8911137_3 Conserved repeat domain - - - 0.00000000000008061 76.0
HKD2_k127_8911137_4 PFAM Peptidoglycan-binding domain 1 protein - - - 0.0000000001982 74.0
HKD2_k127_8941443_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1076.0
HKD2_k127_8941443_1 acetylesterase activity K01066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001334 270.0
HKD2_k127_8941443_2 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000001364 213.0
HKD2_k127_8954744_0 fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 347.0
HKD2_k127_8954744_1 ABC-2 family transporter protein K09696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 348.0
HKD2_k127_8954744_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000159 258.0
HKD2_k127_8954744_3 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000001462 251.0
HKD2_k127_8954744_4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000008119 201.0
HKD2_k127_8954744_5 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000003029 183.0
HKD2_k127_8954744_6 NnrU protein K21310 - 2.1.1.334 0.000000000000000000001124 104.0
HKD2_k127_8969592_0 NADH flavin K00219 - 1.3.1.34 8.67e-206 659.0
HKD2_k127_8969592_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009323 427.0
HKD2_k127_8969592_10 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000001115 132.0
HKD2_k127_8969592_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000002565 140.0
HKD2_k127_8969592_12 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000009821 78.0
HKD2_k127_8969592_13 penicillinase repressor - - - 0.00000001821 61.0
HKD2_k127_8969592_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 409.0
HKD2_k127_8969592_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 383.0
HKD2_k127_8969592_4 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 391.0
HKD2_k127_8969592_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000005606 233.0
HKD2_k127_8969592_6 transglycosylase K08309 - - 0.0000000000000000000000000000000000006289 149.0
HKD2_k127_8969592_7 peroxiredoxin activity - - - 0.00000000000000000000000000000000001818 140.0
HKD2_k127_8969592_8 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000002246 147.0
HKD2_k127_8969592_9 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000003291 134.0
HKD2_k127_8976721_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 312.0
HKD2_k127_8976721_1 Bifunctional protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001531 274.0
HKD2_k127_8976721_2 Hexapeptide repeat of succinyl-transferase K00633 - 2.3.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000267 258.0
HKD2_k127_8976721_3 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000009302 236.0
HKD2_k127_8976721_4 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02527,K02841,K02843,K12982 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000001036 235.0
HKD2_k127_8976721_5 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000006903 220.0
HKD2_k127_8976721_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K00980,K03272 - 2.7.1.167,2.7.7.39,2.7.7.70 0.00000000000000000000000000000000000000000000001156 187.0
HKD2_k127_8976721_7 Phospholipid methyltransferase - - - 0.00000000000000000000000000003229 123.0
HKD2_k127_8976721_8 23S rRNA-intervening sequence protein - - - 0.0000000002301 62.0
HKD2_k127_8985033_0 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 463.0
HKD2_k127_8985033_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 456.0
HKD2_k127_8985033_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001735 257.0
HKD2_k127_8985033_3 cell redox homeostasis - - - 0.000000000000000000035 95.0
HKD2_k127_8985033_4 Belongs to the glycosyl hydrolase 3 family - - - 0.00000000000000003609 85.0
HKD2_k127_8985033_5 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000002875 71.0
HKD2_k127_9005981_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000001785 190.0
HKD2_k127_9005981_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000008114 61.0
HKD2_k127_9024609_0 Glycogen debranching enzyme - - - 2.502e-282 875.0
HKD2_k127_9024609_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 3.066e-194 612.0
HKD2_k127_9024609_10 - - - - 0.00000000000000000000000003777 115.0
HKD2_k127_9024609_11 iron-sulfur cluster assembly - GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - 0.0000000000000000000000009373 104.0
HKD2_k127_9024609_12 transcriptional regulator - - - 0.000000000000008603 80.0
HKD2_k127_9024609_2 heat shock protein 70 K04043,K04044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 617.0
HKD2_k127_9024609_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 359.0
HKD2_k127_9024609_4 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004658 377.0
HKD2_k127_9024609_5 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 317.0
HKD2_k127_9024609_6 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000105 226.0
HKD2_k127_9024609_7 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000002377 169.0
HKD2_k127_9024609_8 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000002574 134.0
HKD2_k127_9024609_9 PFAM heat shock protein DnaJ K04082 - - 0.0000000000000000000000000324 117.0
HKD2_k127_9029037_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K16319 - 1.14.12.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 407.0
HKD2_k127_9029037_1 Transposase IS200 like K07491 - - 0.000000000000000000000000000000000000000000000000000005557 193.0
HKD2_k127_9029037_2 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000004193 197.0
HKD2_k127_9039213_0 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 353.0
HKD2_k127_9039213_1 palmitoyl-(protein) hydrolase activity K06999 - - 0.00000000000000000000000000004496 130.0
HKD2_k127_9039213_2 oxidoreductase activity - - - 0.000000000000000004838 97.0
HKD2_k127_9047603_0 penicillin binding K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 447.0
HKD2_k127_9047603_1 MreB/Mbl protein K03569 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000533 233.0
HKD2_k127_9047603_2 Cell shape-determining protein MreC K03570 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 - 0.00000000000000000000000000000000000002605 154.0
HKD2_k127_9047603_3 Cell cycle protein K05837 - - 0.00000000000000000000000001628 121.0
HKD2_k127_9047603_4 rod shape-determining protein MreD K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.0003225 49.0
HKD2_k127_9055016_0 Protein of unknown function (DUF2851) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006417 275.0
HKD2_k127_9055016_1 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000001568 204.0
HKD2_k127_9055016_2 Polysaccharide deacetylase K22278 GO:0005575,GO:0005623,GO:0016020,GO:0042763,GO:0044464 3.5.1.104 0.000000000000000000000000000000000000000000000002527 181.0
HKD2_k127_9055016_3 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000001641 157.0
HKD2_k127_9055016_4 Radical SAM - - - 0.000000000000000000000000001187 130.0
HKD2_k127_9055016_5 signal transduction histidine kinase - - - 0.0000000000000009478 92.0
HKD2_k127_9073679_0 Molybdopterin oxidoreductase Fe4S4 domain K00370 - 1.7.5.1 0.0 1712.0
HKD2_k127_9073679_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1328.0
HKD2_k127_9073679_10 Sigma-54 interaction domain K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 333.0
HKD2_k127_9073679_11 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003917 270.0
HKD2_k127_9073679_12 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008197 279.0
HKD2_k127_9073679_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001671 257.0
HKD2_k127_9073679_14 - - - - 0.0000000000000000000000000000000000000000000000000000002188 199.0
HKD2_k127_9073679_15 nitrate reductase activity K00370,K00374,K02575 GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 0.00000000000000000000000000000000000000000000000000001425 198.0
HKD2_k127_9073679_16 TonB dependent receptor K16087 - - 0.00000000000000000000000000000000000000000000004496 194.0
HKD2_k127_9073679_17 Cytochrome c - - - 0.00000000000000000000000000000000000000000001229 171.0
HKD2_k127_9073679_18 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000000000000001999 161.0
HKD2_k127_9073679_19 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K02275 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000002348 149.0
HKD2_k127_9073679_2 GTP-binding protein TypA K06207 - - 9.246e-252 794.0
HKD2_k127_9073679_20 von Willebrand factor, type A - - - 0.00000000000000000004906 101.0
HKD2_k127_9073679_21 Cytochrome c K02275,K17223 - 1.9.3.1 0.000000000000000007442 94.0
HKD2_k127_9073679_22 transcriptional regulator - - - 0.00000000000000009208 88.0
HKD2_k127_9073679_23 Iron-binding zinc finger CDGSH type - - - 0.00000000000000507 84.0
HKD2_k127_9073679_24 - - - - 0.000000005924 63.0
HKD2_k127_9073679_25 COG0642 Signal transduction histidine kinase - - - 0.00001179 52.0
HKD2_k127_9073679_3 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 3.315e-208 655.0
HKD2_k127_9073679_4 TIGRFAM nitrate reductase, beta subunit K00371 - 1.7.5.1 3.852e-202 645.0
HKD2_k127_9073679_5 Cytochrome C oxidase subunit I K02274 - 1.9.3.1 5.537e-199 634.0
HKD2_k127_9073679_6 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 491.0
HKD2_k127_9073679_7 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 475.0
HKD2_k127_9073679_8 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 401.0
HKD2_k127_9073679_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 347.0
HKD2_k127_9103181_0 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 380.0
HKD2_k127_9103181_1 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 347.0
HKD2_k127_9103181_2 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 316.0
HKD2_k127_9103181_3 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000002633 169.0
HKD2_k127_9103181_4 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000001716 109.0
HKD2_k127_9113175_0 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002037 271.0
HKD2_k127_9113175_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008324 280.0
HKD2_k127_9113175_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000003654 189.0
HKD2_k127_9113175_3 Putative stress-induced transcription regulator - - - 0.000000000000000000002426 94.0
HKD2_k127_9115870_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 521.0
HKD2_k127_9115870_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 463.0
HKD2_k127_9115870_10 Cytochrome c7 and related cytochrome c - - - 0.000003333 60.0
HKD2_k127_9115870_2 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 427.0
HKD2_k127_9115870_3 4 iron, 4 sulfur cluster binding K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 311.0
HKD2_k127_9115870_4 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001885 271.0
HKD2_k127_9115870_5 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002766 248.0
HKD2_k127_9115870_6 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000005928 163.0
HKD2_k127_9115870_7 PFAM glycine cleavage H-protein - - - 0.0000000000000000000000000001571 125.0
HKD2_k127_9115870_8 Glycine cleavage H-protein - - - 0.0000000000000000000000005833 113.0
HKD2_k127_9115870_9 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000000000000000002172 109.0
HKD2_k127_9123953_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 344.0
HKD2_k127_9123953_1 Aspartyl protease - - - 0.0000000000002234 83.0
HKD2_k127_9123953_2 PAS fold - - - 0.0000000001662 70.0
HKD2_k127_9123953_3 Acyl-transferase K00655 - 2.3.1.51 0.0000000101 65.0
HKD2_k127_9150815_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 561.0
HKD2_k127_9150815_1 SMART helicase c2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 484.0
HKD2_k127_9150815_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030312,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0040007,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 331.0
HKD2_k127_9150815_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000006839 254.0
HKD2_k127_9150815_4 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000009591 222.0
HKD2_k127_9150815_5 TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000007026 175.0
HKD2_k127_9150815_6 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K04068,K10026 - 1.97.1.4,4.3.99.3 0.0000000000000000000000000000000000000004047 151.0
HKD2_k127_9150815_7 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000001356 149.0
HKD2_k127_9150815_8 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000007062 126.0
HKD2_k127_9150815_9 Yqey-like protein K09117 - - 0.000000000000000000000000001551 119.0
HKD2_k127_9208349_0 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000616 203.0
HKD2_k127_9208349_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000348 161.0
HKD2_k127_9208349_2 - - - - 0.00000000000000000000000000000000003265 142.0
HKD2_k127_9208349_3 Protein glycosylation ligase - - - 0.0001606 55.0
HKD2_k127_9215251_0 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 379.0
HKD2_k127_9215251_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 293.0
HKD2_k127_9215251_2 Highly conserved protein containing a thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000009046 247.0
HKD2_k127_9215251_3 Belongs to the peptidase S8 family K08651,K14743 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000001503 234.0
HKD2_k127_9215251_4 Response regulator receiver domain K03413 - - 0.0000000000000000000000000000000000000007565 157.0
HKD2_k127_921585_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 5.975e-223 703.0
HKD2_k127_921585_1 Protein kinase domain K12132 - 2.7.11.1 5.712e-214 694.0
HKD2_k127_921585_10 haloacid dehalogenase-like hydrolase - - - 0.00000002687 58.0
HKD2_k127_921585_2 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 580.0
HKD2_k127_921585_3 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 403.0
HKD2_k127_921585_4 Cytochrome b(C-terminal)/b6/petD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 344.0
HKD2_k127_921585_5 Abc transporter K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 302.0
HKD2_k127_921585_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000001996 194.0
HKD2_k127_921585_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000002466 125.0
HKD2_k127_921585_8 - - - - 0.0000000000000002039 89.0
HKD2_k127_921585_9 deoxyhypusine monooxygenase activity - - - 0.0000000002983 71.0
HKD2_k127_9251603_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 402.0
HKD2_k127_9251603_1 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 317.0
HKD2_k127_9251603_2 Belongs to the glycosyl hydrolase 18 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 322.0
HKD2_k127_9251603_3 amino acid K03294 - - 0.00002325 57.0
HKD2_k127_9256049_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 363.0
HKD2_k127_9256049_1 transporter (permease K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004428 271.0
HKD2_k127_9256049_2 FMN reductase (NADPH) activity - - - 0.000000000000000000000000000000000000000000000000000000003439 206.0
HKD2_k127_9256049_3 PFAM Iron permease FTR1 - - - 0.00000000000000000000000000000000000000000000000000000001225 207.0
HKD2_k127_9256049_4 Transcriptional regulator, LysR - - - 0.000000000000000000000000000000000000000000000006473 180.0
HKD2_k127_9256049_5 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000132 157.0
HKD2_k127_9256049_6 MacB-like periplasmic core domain K02004 - - 0.000000000000000001861 98.0
HKD2_k127_9324459_0 acetyltransferase - - - 0.00000000000000000000000000006958 127.0
HKD2_k127_9324459_1 PFAM Peptidoglycan-binding domain 1 protein - - - 0.000000001352 70.0
HKD2_k127_9328755_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.303e-271 844.0
HKD2_k127_9328755_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 511.0
HKD2_k127_9328755_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 421.0
HKD2_k127_9328755_3 dUTPase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000001369 214.0
HKD2_k127_9328755_4 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000002288 166.0
HKD2_k127_9328755_5 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000009838 131.0
HKD2_k127_9328755_6 BioY family K03523 - - 0.00000000000000000000000004997 115.0
HKD2_k127_9328755_7 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.000000000000003279 80.0
HKD2_k127_9362092_0 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 524.0
HKD2_k127_9362092_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000000000000000000000000003598 183.0
HKD2_k127_9362092_2 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000602 184.0
HKD2_k127_9362092_3 deoxyhypusine monooxygenase activity - - - 0.0000000000000000001446 92.0
HKD2_k127_9364439_0 Associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 493.0
HKD2_k127_9364439_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 466.0
HKD2_k127_9364439_10 Transcriptional regulator - - - 0.0000000000000000000000000000004831 128.0
HKD2_k127_9364439_11 - - - - 0.00000000000000000000000003864 120.0
HKD2_k127_9364439_12 RDD family - - - 0.000000000000149 81.0
HKD2_k127_9364439_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 453.0
HKD2_k127_9364439_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 438.0
HKD2_k127_9364439_4 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 385.0
HKD2_k127_9364439_5 Von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 379.0
HKD2_k127_9364439_6 Von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 366.0
HKD2_k127_9364439_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000005953 180.0
HKD2_k127_9364439_8 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000007521 174.0
HKD2_k127_9364439_9 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000002342 165.0
HKD2_k127_937276_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 1.303e-260 826.0
HKD2_k127_937276_1 polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 363.0
HKD2_k127_937276_2 glycosyl hydrolase, BNR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006051 255.0
HKD2_k127_9375981_0 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 384.0
HKD2_k127_9375981_1 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 308.0
HKD2_k127_9375981_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000002957 234.0
HKD2_k127_9375981_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02022,K16922,K20345 - - 0.000000000000000000000000000000000000000000000000000000000000003766 242.0
HKD2_k127_9375981_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.000000000000000000000000000000000000000000000000000000001607 226.0
HKD2_k127_9375981_5 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000002295 54.0
HKD2_k127_9375981_6 Integrin alpha K06482,K06485,K06583 GO:0000003,GO:0000902,GO:0000904,GO:0001568,GO:0001655,GO:0001667,GO:0001704,GO:0001706,GO:0001707,GO:0001764,GO:0001822,GO:0001891,GO:0001894,GO:0001944,GO:0001968,GO:0002009,GO:0002020,GO:0002119,GO:0002164,GO:0002165,GO:0002376,GO:0003002,GO:0003006,GO:0003008,GO:0003014,GO:0003674,GO:0004888,GO:0005102,GO:0005178,GO:0005488,GO:0005515,GO:0005518,GO:0005520,GO:0005575,GO:0005576,GO:0005604,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0005913,GO:0005924,GO:0005925,GO:0005927,GO:0006355,GO:0006357,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007015,GO:0007044,GO:0007154,GO:0007155,GO:0007157,GO:0007160,GO:0007165,GO:0007166,GO:0007229,GO:0007275,GO:0007369,GO:0007389,GO:0007398,GO:0007399,GO:0007409,GO:0007411,GO:0007413,GO:0007414,GO:0007424,GO:0007426,GO:0007427,GO:0007431,GO:0007432,GO:0007435,GO:0007439,GO:0007444,GO:0007472,GO:0007475,GO:0007476,GO:0007492,GO:0007494,GO:0007498,GO:0007517,GO:0007519,GO:0007548,GO:0007552,GO:0007560,GO:0007600,GO:0007606,GO:0007608,GO:0007610,GO:0007611,GO:0007613,GO:0008037,GO:0008038,GO:0008078,GO:0008150,GO:0008305,GO:0008587,GO:0009605,GO:0009653,GO:0009790,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009889,GO:0009891,GO:0009893,GO:0009897,GO:0009925,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0009991,GO:0010160,GO:0010171,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010631,GO:0010632,GO:0010634,GO:0010646,GO:0010648,GO:0010668,GO:0010669,GO:0010720,GO:0010810,GO:0010811,GO:0010941,GO:0010942,GO:0010975,GO:0010976,GO:0014706,GO:0016020,GO:0016021,GO:0016043,GO:0016203,GO:0016323,GO:0016324,GO:0016328,GO:0016477,GO:0017015,GO:0019219,GO:0019220,GO:0019222,GO:0019838,GO:0019899,GO:0019904,GO:0022008,GO:0022407,GO:0022409,GO:0022414,GO:0022607,GO:0022610,GO:0022612,GO:0023051,GO:0023052,GO:0023057,GO:0030029,GO:0030030,GO:0030031,GO:0030036,GO:0030054,GO:0030055,GO:0030056,GO:0030111,GO:0030154,GO:0030155,GO:0030175,GO:0030182,GO:0030198,GO:0030323,GO:0030324,GO:0030334,GO:0030335,GO:0030424,GO:0030426,GO:0030427,GO:0030510,GO:0031012,GO:0031175,GO:0031224,GO:0031226,GO:0031253,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031344,GO:0031345,GO:0031346,GO:0031527,GO:0031581,GO:0031589,GO:0031594,GO:0031668,GO:0031994,GO:0032228,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032989,GO:0032990,GO:0032991,GO:0033267,GO:0033627,GO:0033631,GO:0034113,GO:0034329,GO:0034330,GO:0034446,GO:0034667,GO:0034676,GO:0034677,GO:0035023,GO:0035024,GO:0035107,GO:0035114,GO:0035120,GO:0035152,GO:0035160,GO:0035220,GO:0035239,GO:0035272,GO:0035295,GO:0035640,GO:0035878,GO:0035987,GO:0038023,GO:0038132,GO:0040011,GO:0040012,GO:0040017,GO:0042221,GO:0042325,GO:0042327,GO:0042330,GO:0042383,GO:0042475,GO:0042476,GO:0042592,GO:0042981,GO:0042995,GO:0043005,GO:0043062,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043087,GO:0043235,GO:0043236,GO:0043547,GO:0043588,GO:0043954,GO:0044085,GO:0044093,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045138,GO:0045177,GO:0045178,GO:0045202,GO:0045444,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045785,GO:0045893,GO:0045935,GO:0045937,GO:0045944,GO:0046578,GO:0046580,GO:0046661,GO:0046847,GO:0046982,GO:0046983,GO:0048332,GO:0048333,GO:0048468,GO:0048471,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048546,GO:0048563,GO:0048565,GO:0048567,GO:0048569,GO:0048583,GO:0048585,GO:0048598,GO:0048645,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048732,GO:0048736,GO:0048737,GO:0048812,GO:0048856,GO:0048858,GO:0048859,GO:0048869,GO:0048870,GO:0048871,GO:0050767,GO:0050769,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050804,GO:0050808,GO:0050839,GO:0050840,GO:0050873,GO:0050877,GO:0050890,GO:0050896,GO:0050900,GO:0051056,GO:0051058,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051252,GO:0051254,GO:0051270,GO:0051272,GO:0051336,GO:0051345,GO:0051674,GO:0051716,GO:0051960,GO:0051962,GO:0055123,GO:0060076,GO:0060089,GO:0060173,GO:0060249,GO:0060255,GO:0060284,GO:0060341,GO:0060429,GO:0060537,GO:0060538,GO:0060541,GO:0060548,GO:0060562,GO:0061061,GO:0061564,GO:0062023,GO:0065007,GO:0065008,GO:0065009,GO:0070161,GO:0071437,GO:0071438,GO:0071496,GO:0071840,GO:0071944,GO:0072001,GO:0072006,GO:0072358,GO:0072359,GO:0080090,GO:0090092,GO:0090130,GO:0090132,GO:0090287,GO:0090598,GO:0097060,GO:0097061,GO:0097062,GO:0097186,GO:0097205,GO:0097435,GO:0097458,GO:0097485,GO:0098552,GO:0098590,GO:0098609,GO:0098636,GO:0098742,GO:0098796,GO:0098797,GO:0098802,GO:0098858,GO:0099173,GO:0099177,GO:0106027,GO:0106030,GO:0120025,GO:0120031,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1902531,GO:1902532,GO:1902680,GO:1903076,GO:1903078,GO:1903506,GO:1903508,GO:1903827,GO:1903829,GO:1903844,GO:1904375,GO:1904377,GO:1905475,GO:1905477,GO:2000026,GO:2000112,GO:2000145,GO:2000147,GO:2001141,GO:2001233,GO:2001234,GO:2001236,GO:2001237 - 0.00004721 48.0
HKD2_k127_9375981_7 - - - - 0.0001479 46.0
HKD2_k127_937644_0 CobW/HypB/UreG, nucleotide-binding domain - - - 3.49e-197 623.0
HKD2_k127_937644_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 379.0
HKD2_k127_937644_2 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 376.0
HKD2_k127_937644_3 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 356.0
HKD2_k127_937644_4 Putative diguanylate phosphodiesterase K21023 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 320.0
HKD2_k127_937644_5 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000002641 190.0
HKD2_k127_937644_6 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K06878 - - 0.0000000000000000000000000000000000000000000000452 172.0
HKD2_k127_937644_7 hydrolase of the alpha beta K07018 - - 0.00000000000000000000000000000000000000000002918 169.0
HKD2_k127_937644_8 amine dehydrogenase activity K21449 - - 0.000000000000000000000000000000000004008 143.0
HKD2_k127_937644_9 cheY-homologous receiver domain K03413 - - 0.0000000000001707 76.0
HKD2_k127_9376784_0 prohibitin homologues K07192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 398.0
HKD2_k127_9376784_1 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003055 254.0
HKD2_k127_9376784_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000004982 148.0
HKD2_k127_9376784_3 Domain of unknown function (DUF4266) - - - 0.0000000000000001098 82.0
HKD2_k127_9376784_4 Membrane protein implicated in regulation of membrane protease activity - - - 0.00001286 54.0
HKD2_k127_9384651_0 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 387.0
HKD2_k127_9384651_1 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 388.0
HKD2_k127_9396026_0 peptidase K07386 - - 2.991e-250 792.0
HKD2_k127_9396026_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 410.0
HKD2_k127_9396026_10 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000001609 222.0
HKD2_k127_9396026_11 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000006149 190.0
HKD2_k127_9396026_12 Diguanylate cyclase - - - 0.000000000000000000000000000000000000003553 149.0
HKD2_k127_9396026_13 long-chain fatty acid transporting porin activity K06076 - - 0.0000000000000000000003753 106.0
HKD2_k127_9396026_14 long-chain fatty acid transporting porin activity K06076 - - 0.0000000000000000000005272 102.0
HKD2_k127_9396026_15 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000007121 94.0
HKD2_k127_9396026_2 PFAM Xanthine uracil vitamin C permease K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 395.0
HKD2_k127_9396026_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 396.0
HKD2_k127_9396026_4 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 328.0
HKD2_k127_9396026_5 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 322.0
HKD2_k127_9396026_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 326.0
HKD2_k127_9396026_7 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008291 283.0
HKD2_k127_9396026_8 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009926 293.0
HKD2_k127_9396026_9 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000001126 225.0
HKD2_k127_9400869_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 2.575e-256 802.0
HKD2_k127_9400869_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 623.0
HKD2_k127_9400869_2 (ABC) transporter K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 542.0
HKD2_k127_9400869_3 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 454.0
HKD2_k127_9400869_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 369.0
HKD2_k127_9400869_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000005067 216.0
HKD2_k127_9400869_6 Protein of unknown function (DUF1706) - - - 0.000000000000000004391 90.0
HKD2_k127_9400869_7 - - - - 0.00000000003281 69.0
HKD2_k127_9400869_8 - - - - 0.000000008477 64.0
HKD2_k127_9400869_9 Protein of unknown function (DUF2934) - - - 0.00001059 53.0
HKD2_k127_9413421_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 1.291e-265 823.0
HKD2_k127_9413421_1 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 493.0
HKD2_k127_9413421_2 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 478.0
HKD2_k127_9413421_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 403.0
HKD2_k127_9413421_4 beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 317.0
HKD2_k127_9413421_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004734 263.0
HKD2_k127_9413421_6 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000003926 201.0
HKD2_k127_9436572_0 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001645 256.0
HKD2_k127_9436572_2 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000005751 224.0
HKD2_k127_9436572_3 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000005469 209.0
HKD2_k127_9436572_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000002253 166.0
HKD2_k127_9436572_5 Domain of unknown function (DUF4440) - - - 0.00000000000000000000009428 106.0
HKD2_k127_9436572_6 membrane - - - 0.000006619 57.0
HKD2_k127_944979_0 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 611.0
HKD2_k127_944979_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 295.0
HKD2_k127_944979_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000002513 242.0
HKD2_k127_944979_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000005868 209.0
HKD2_k127_944979_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000711 137.0
HKD2_k127_944979_5 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852,K00856,K10710,K22026 - 2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73 0.00000000000000001018 92.0
HKD2_k127_944979_6 - - - - 0.0000006213 62.0
HKD2_k127_9458915_0 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000002641 190.0
HKD2_k127_9458915_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000007747 136.0
HKD2_k127_9458915_2 Heat shock protein DnaJ domain protein - - - 0.000000000000000005005 99.0
HKD2_k127_9458915_3 Bacterial regulatory proteins, crp family - - - 0.000000001106 64.0
HKD2_k127_945991_0 RNA ligase activity K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 603.0
HKD2_k127_945991_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 448.0
HKD2_k127_945991_2 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003884 244.0
HKD2_k127_945991_3 Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000003803 178.0
HKD2_k127_945991_4 Acetyltransferase (GNAT) domain K22441 - 2.3.1.57 0.00000000000000000000000000000000000004892 154.0
HKD2_k127_945991_5 DinB family - - - 0.000000000000000000000000000000000006378 141.0
HKD2_k127_945991_6 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000006483 55.0
HKD2_k127_9518021_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 464.0
HKD2_k127_9518021_1 SMART Elongator protein 3 MiaB NifB K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000003229 235.0
HKD2_k127_9521672_0 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004401 283.0
HKD2_k127_9521672_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000007257 233.0
HKD2_k127_9521672_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000000000000008189 184.0
HKD2_k127_9521672_3 EamA-like transporter family - - - 0.00000000000000000000000000000000007011 140.0
HKD2_k127_9521672_4 Outer membrane protein (OmpH-like) K06142 - - 0.0000000006695 65.0
HKD2_k127_9521911_0 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 407.0
HKD2_k127_9521911_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000594 393.0
HKD2_k127_9521911_10 Pfam:DUF59 K02612 - - 0.0000000000000000000000000000000003844 133.0
HKD2_k127_9521911_11 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.0000000000000000003711 92.0
HKD2_k127_9521911_12 Surface antigen - - - 0.000000000000005155 88.0
HKD2_k127_9521911_2 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 381.0
HKD2_k127_9521911_3 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 373.0
HKD2_k127_9521911_4 PFAM Thiamine pyrophosphate K00170,K00187 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 348.0
HKD2_k127_9521911_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005396 276.0
HKD2_k127_9521911_6 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000001056 204.0
HKD2_k127_9521911_7 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000001082 203.0
HKD2_k127_9521911_8 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000001229 187.0
HKD2_k127_9521911_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000008275 160.0
HKD2_k127_9525220_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 499.0
HKD2_k127_9525220_1 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 391.0
HKD2_k127_9525220_2 Protein of unknown function (DUF1295) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 312.0
HKD2_k127_9525220_3 Protein of unknown function (DUF1475) - - - 0.0000000001513 63.0
HKD2_k127_9525220_4 Protein of unknown function (DUF1365) K09701 - - 0.0000001147 57.0
HKD2_k127_9528160_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 5.387e-257 807.0
HKD2_k127_9528160_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000003703 227.0
HKD2_k127_9528160_2 - - - - 0.0000000000000000000000000000000515 130.0
HKD2_k127_9528160_3 PFAM plasmid K06218 - - 0.000001563 53.0
HKD2_k127_9528160_4 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00004876 49.0
HKD2_k127_9549224_0 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 621.0
HKD2_k127_9549224_1 - - - - 0.000000000000000000000000000000000106 142.0
HKD2_k127_9604161_0 PFAM Type II secretion system protein E K02652 - - 1.939e-224 709.0
HKD2_k127_9604161_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 517.0
HKD2_k127_9604161_10 Pilus assembly protein K02662 - - 0.000000002777 67.0
HKD2_k127_9604161_11 - - - - 0.0000002121 61.0
HKD2_k127_9604161_12 Secretin and TonB N terminus short domain K02666 - - 0.00001659 55.0
HKD2_k127_9604161_13 carbon utilization - - - 0.0001128 53.0
HKD2_k127_9604161_2 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 417.0
HKD2_k127_9604161_3 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 418.0
HKD2_k127_9604161_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 391.0
HKD2_k127_9604161_5 type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002703 299.0
HKD2_k127_9604161_6 ABC-type dipeptide transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000006105 229.0
HKD2_k127_9604161_7 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000004311 121.0
HKD2_k127_9604161_8 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000006594 114.0
HKD2_k127_9604161_9 Pilus assembly protein K02662 - - 0.0000000000000005301 89.0
HKD2_k127_9607518_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 9.194e-316 989.0
HKD2_k127_9607518_1 Belongs to the pyruvate kinase family K00873 GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 427.0
HKD2_k127_9607518_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 296.0
HKD2_k127_9607518_3 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000001247 265.0
HKD2_k127_9607518_4 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001157 275.0
HKD2_k127_9607518_5 type II secretion system protein K02243,K02652 - - 0.00000000000000000000000000000000000000000000000000001697 205.0
HKD2_k127_9607518_6 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000005474 186.0
HKD2_k127_9607518_7 cheY-homologous receiver domain - - - 0.000000000000000000000000000003242 137.0
HKD2_k127_9607518_8 outer membrane autotransporter barrel domain protein - - - 0.000000000000003402 84.0
HKD2_k127_9607518_9 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07713,K07714,K19641 - - 0.000000000002561 70.0
HKD2_k127_9625463_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 547.0
HKD2_k127_9625463_1 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 443.0
HKD2_k127_9625463_10 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000003634 217.0
HKD2_k127_9625463_11 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000002777 179.0
HKD2_k127_9625463_12 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000007762 173.0
HKD2_k127_9625463_13 C4-type zinc ribbon domain K07164 - - 0.000000000000000000000000000000008747 137.0
HKD2_k127_9625463_14 Hfq protein - - - 0.00000000000000000000000000001048 121.0
HKD2_k127_9625463_15 Belongs to the bacterial histone-like protein family K03530 - - 0.000000000000000000000000001257 114.0
HKD2_k127_9625463_16 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000001124 117.0
HKD2_k127_9625463_17 Protein of unknown function (DUF3467) - - - 0.000000000000001336 81.0
HKD2_k127_9625463_18 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000425 80.0
HKD2_k127_9625463_19 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000502 82.0
HKD2_k127_9625463_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 403.0
HKD2_k127_9625463_20 Transcription factor zinc-finger K09981 - - 0.000000000004607 72.0
HKD2_k127_9625463_3 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 391.0
HKD2_k127_9625463_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 344.0
HKD2_k127_9625463_5 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 320.0
HKD2_k127_9625463_6 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004843 289.0
HKD2_k127_9625463_7 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002531 275.0
HKD2_k127_9625463_8 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K22024 - 1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000003578 247.0
HKD2_k127_9625463_9 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000001469 235.0
HKD2_k127_9640139_0 4Fe-4S binding domain - - - 1.29e-252 801.0
HKD2_k127_9640139_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 414.0
HKD2_k127_9640139_2 unfolded protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 335.0
HKD2_k127_9640139_4 Aldo/keto reductase family K07079 - - 0.000000000000000000000000004414 114.0
HKD2_k127_9708503_0 lipopolysaccharide transport K22110 - - 0.0 1370.0
HKD2_k127_9708503_1 dipeptidyl-peptidase activity K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 367.0
HKD2_k127_9708503_2 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000004586 255.0
HKD2_k127_9708503_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000009523 177.0
HKD2_k127_9758045_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 396.0
HKD2_k127_9758045_1 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 302.0
HKD2_k127_9758045_2 lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000003713 225.0
HKD2_k127_9758045_3 type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000000007877 195.0
HKD2_k127_9758045_4 arylsulfatase activity K01133 - 3.1.6.6 0.000000000000000000000000000000000000000005946 174.0
HKD2_k127_9758045_5 Thioesterase superfamily - - - 0.000000000000000000000000000000000005011 141.0
HKD2_k127_9758045_6 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000003116 115.0
HKD2_k127_9758045_7 major facilitator superfamily - - - 0.0000000000000000000000000337 122.0
HKD2_k127_9758045_8 Sporulation related domain - - - 0.00000001089 66.0
HKD2_k127_9774114_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 508.0
HKD2_k127_9817377_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 549.0
HKD2_k127_9817377_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 334.0
HKD2_k127_9817377_10 Prokaryotic Cytochrome C oxidase subunit IV - - - 0.00003749 51.0
HKD2_k127_9817377_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000002201 265.0
HKD2_k127_9817377_3 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003008 256.0
HKD2_k127_9817377_4 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000009626 242.0
HKD2_k127_9817377_5 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000009327 242.0
HKD2_k127_9817377_6 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000304 206.0
HKD2_k127_9817377_7 Cytochrome oxidase assembly protein K02259 - - 0.00000000000000000000000000000000000000000000004032 183.0
HKD2_k127_9817377_8 response regulator receiver K02487,K06596 - - 0.00000000000008732 82.0
HKD2_k127_9823948_0 PFAM Formiminotransferase K00603 - 2.1.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 364.0
HKD2_k127_9823948_1 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001101 263.0
HKD2_k127_9823948_2 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000001577 217.0
HKD2_k127_9823948_3 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000004606 209.0
HKD2_k127_9823948_4 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000002758 175.0
HKD2_k127_9823948_5 Universal stress protein - - - 0.00000000000000001202 93.0
HKD2_k127_9836058_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 8.714e-264 836.0
HKD2_k127_9836058_1 exo-alpha-(2->6)-sialidase activity K01186 GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509 3.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 353.0
HKD2_k127_9836058_2 exo-alpha-(2->6)-sialidase activity K01186 GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509 3.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 349.0
HKD2_k127_9836058_3 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 308.0
HKD2_k127_9836058_4 SMART tyrosine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000001628 231.0
HKD2_k127_9836058_5 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000005564 116.0
HKD2_k127_9836058_6 Domain of unknown function (DUF4404) - - - 0.0000000000000000005572 90.0
HKD2_k127_9836058_7 Pectate lyase - - - 0.000000000006898 74.0
HKD2_k127_9836058_8 Hint domain - - - 0.0001634 53.0
HKD2_k127_9848435_0 DNA photolyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005716 403.0
HKD2_k127_9848435_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - 0.0000000000000000000000000000008912 141.0
HKD2_k127_9848435_2 Diguanylate cyclase K21020 - 2.7.7.65 0.0000000002884 63.0
HKD2_k127_9848435_3 Gaf domain K03832 - - 0.000000003286 67.0
HKD2_k127_9850829_0 Radical SAM - - - 3.062e-296 921.0
HKD2_k127_9850829_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 527.0
HKD2_k127_9850829_10 Tfp pilus assembly protein FimV - - - 0.0000000000000000000000000000000006157 147.0
HKD2_k127_9850829_11 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000001067 137.0
HKD2_k127_9850829_12 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.0000002473 61.0
HKD2_k127_9850829_15 - - - - 0.00005759 54.0
HKD2_k127_9850829_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 505.0
HKD2_k127_9850829_3 ABC 3 transport family K02075,K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002509 274.0
HKD2_k127_9850829_4 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000002851 229.0
HKD2_k127_9850829_5 arylsulfatase A - - - 0.00000000000000000000000000000000000000000000000000000000000001558 232.0
HKD2_k127_9850829_6 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000001078 228.0
HKD2_k127_9850829_7 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000008638 183.0
HKD2_k127_9850829_8 radical SAM domain protein - - - 0.000000000000000000000000000000000000000006911 168.0
HKD2_k127_9850829_9 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000006607 162.0
HKD2_k127_9857128_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 442.0
HKD2_k127_9857128_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46,4.2.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 415.0
HKD2_k127_9857128_2 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001812 280.0
HKD2_k127_9857128_3 Polysaccharide biosynthesis protein K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000001067 243.0
HKD2_k127_9857128_4 Male sterility protein K15891 - 1.1.1.354 0.000000000000000000000000000000000000000000000000000000000000004469 231.0
HKD2_k127_9857128_5 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000001589 163.0
HKD2_k127_9864926_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 393.0
HKD2_k127_9864926_1 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008841 379.0
HKD2_k127_9864926_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 336.0
HKD2_k127_9864926_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 316.0
HKD2_k127_9864926_4 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000004854 157.0
HKD2_k127_9892774_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 588.0
HKD2_k127_9892774_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009755 524.0
HKD2_k127_9892774_10 Large extracellular alpha-helical protein K06894 - - 0.00000000000000000000000000000000000000005638 157.0
HKD2_k127_9892774_11 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000005935 145.0
HKD2_k127_9892774_12 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000000000000004466 141.0
HKD2_k127_9892774_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000006448 138.0
HKD2_k127_9892774_15 Glutathione peroxidase K02199 - - 0.000000000000000000000000000007015 124.0
HKD2_k127_9892774_16 cheY-homologous receiver domain K07668 - - 0.00000000000000000000000002443 117.0
HKD2_k127_9892774_17 response regulator receiver K02658 - - 0.00000000000000000000001288 106.0
HKD2_k127_9892774_18 Glutaredoxin-like domain (DUF836) - - - 0.00000000001109 71.0
HKD2_k127_9892774_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 343.0
HKD2_k127_9892774_3 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008795 260.0
HKD2_k127_9892774_4 PFAM Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000009383 240.0
HKD2_k127_9892774_5 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000001866 242.0
HKD2_k127_9892774_6 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000001598 217.0
HKD2_k127_9892774_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000149 197.0
HKD2_k127_9892774_8 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000005092 199.0
HKD2_k127_9892774_9 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000008552 189.0
HKD2_k127_9923917_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000181 184.0
HKD2_k127_9923917_1 Peptidase family M23 K01406 - 3.4.24.40 0.0000000000000000000000007864 117.0
HKD2_k127_9924758_0 Male sterility protein K01897 - 6.2.1.3 0.0 1239.0
HKD2_k127_9924758_1 Transmembrane secretion effector K08225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 369.0
HKD2_k127_9924758_2 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008013 351.0
HKD2_k127_9924758_3 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 338.0
HKD2_k127_9924758_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 320.0
HKD2_k127_9924758_5 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 311.0
HKD2_k127_9924758_6 DinB superfamily - - - 0.0000000000000000000000000000006441 129.0
HKD2_k127_9932281_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1317.0
HKD2_k127_9932281_1 cellulose binding - - - 0.0 1276.0
HKD2_k127_9932281_10 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000001314 166.0
HKD2_k127_9932281_11 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000001518 156.0
HKD2_k127_9932281_12 Domain of unknown function (DUF4154) - - - 0.000000000000000000000000002507 119.0
HKD2_k127_9932281_13 Histidine kinase - - - 0.00001612 55.0
HKD2_k127_9932281_14 lipoprotein involved in nitrous oxide reduction K19342 - - 0.00002531 53.0
HKD2_k127_9932281_2 O-methyltransferase - - - 2.928e-255 808.0
HKD2_k127_9932281_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 6.218e-207 666.0
HKD2_k127_9932281_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 373.0
HKD2_k127_9932281_5 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 371.0
HKD2_k127_9932281_6 2Fe-2S -binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000003444 243.0
HKD2_k127_9932281_7 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000009191 211.0
HKD2_k127_9932281_8 photoreceptor activity K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000008469 196.0
HKD2_k127_9932281_9 ferredoxin-NADP+ reductase activity - - - 0.000000000000000000000000000000000000000000003173 175.0
HKD2_k127_9963639_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 315.0
HKD2_k127_9963639_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 296.0
HKD2_k127_9963639_2 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004211 262.0
HKD2_k127_9963639_3 Deoxynucleoside kinase K15518 - 2.7.1.113 0.00000000000000000000000000000000000000000000000000000000000000001162 230.0
HKD2_k127_9963639_4 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000001785 226.0
HKD2_k127_9963639_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000008246 153.0
HKD2_k127_9963639_6 Sporulation and spore germination - - - 0.000000000000000000000000007017 120.0
HKD2_k127_9963639_7 Pantoate-beta-alanine ligase K01918 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0042803,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046983,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0051186,GO:0051188,GO:0061458,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000005891 75.0
HKD2_k127_9967048_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006955 336.0
HKD2_k127_9967048_1 Seven times multi-haem cytochrome CxxCH - - - 0.0000000000000000000000000000000000000000000000000008666 186.0
HKD2_k127_9969851_0 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 295.0
HKD2_k127_9969851_1 6-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000203 230.0
HKD2_k127_9969851_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000003095 188.0
HKD2_k127_9969851_3 denitrification pathway - - - 0.0000000000000000000000000000008809 128.0
HKD2_k127_9969851_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000009014 95.0
HKD2_k127_9969851_6 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K03769,K07533 - 5.2.1.8 0.000003125 59.0
HKD2_k127_9969851_7 Cytochrome c554 and c-prime - - - 0.0003924 53.0
HKD2_k127_9987090_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.766e-262 835.0
HKD2_k127_9987090_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.287e-245 786.0
HKD2_k127_9987090_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 516.0
HKD2_k127_9987090_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 435.0
HKD2_k127_9987090_4 COG1226 Kef-type K transport systems K08714 - - 0.0000000000000000000000000000000000000000000000000000006234 206.0
HKD2_k127_9987090_5 Belongs to the heme-copper respiratory oxidase family - - - 0.000000000000000000838 95.0
HKD2_k127_9987090_6 - - - - 0.000000000000000009251 91.0
HKD2_k127_9987090_7 Modulates RecA activity K03565 - - 0.00000000002002 70.0
HKD2_k127_9998644_0 Histidine kinase - - - 7.425e-274 898.0
HKD2_k127_9998644_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K19694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 413.0
HKD2_k127_9998644_2 Sigma factor PP2C-like phosphatases K01079,K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000003258 259.0
HKD2_k127_9998644_3 antisigma factor binding K02066,K04749 - - 0.000000000000000000000006447 105.0