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Overview

ID MAG01824
Name HKD2_bin.85
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Casimicrobiaceae
Genus VBCG01
Species
Assembly information
Completeness (%) 73.26
Contamination (%) 0.63
GC content (%) 70.0
N50 (bp) 21,125
Genome size (bp) 2,666,910

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2440

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_1026660_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 7.358e-281 883.0
HKD2_k127_1026660_1 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 433.0
HKD2_k127_1026660_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 353.0
HKD2_k127_1026660_3 Belongs to the skp family K06142 - - 0.00000000000000000000000000000000000000000000000000000004097 201.0
HKD2_k127_1293098_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 580.0
HKD2_k127_1293098_1 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 555.0
HKD2_k127_1293098_2 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 422.0
HKD2_k127_1293098_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 333.0
HKD2_k127_1293098_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000133 285.0
HKD2_k127_1293098_5 Ferric uptake regulator family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000642 237.0
HKD2_k127_1293098_6 alpha-L-arabinofuranosidase - - - 0.00000000000000000000000000000000000000000003311 174.0
HKD2_k127_1293098_7 - - - - 0.00000000000000000000000000000002436 128.0
HKD2_k127_1293098_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.0000000000000000000000004602 116.0
HKD2_k127_1293098_9 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000009042 99.0
HKD2_k127_1331218_0 PFAM NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1142.0
HKD2_k127_1331218_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 427.0
HKD2_k127_1331218_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000923 303.0
HKD2_k127_1331218_3 PFAM regulatory protein, MarR - - - 0.0000000000000000000000000000000000000000000000000002367 201.0
HKD2_k127_1331218_4 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.0000000000000000000000000001656 126.0
HKD2_k127_1331218_5 Type II transport protein GspH K08084 - - 0.00000000000000000000000002919 120.0
HKD2_k127_1331218_6 Type II transport protein GspH K08084 - - 0.00000000000001466 81.0
HKD2_k127_1331218_7 type IV pilus modification protein PilV K02671 - - 0.0000000002217 73.0
HKD2_k127_1337851_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 604.0
HKD2_k127_1337851_1 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 314.0
HKD2_k127_1337851_2 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001398 265.0
HKD2_k127_1337851_3 Cytochrome c K17223 - - 0.0000000000000000000000000000000000000000003035 175.0
HKD2_k127_1337851_4 sulfur oxidation protein (SoxY) K17226 - - 0.0000000000000000000000000000000001646 145.0
HKD2_k127_1337851_5 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000000696 141.0
HKD2_k127_1342126_0 Malic enzyme K00029 - 1.1.1.40 0.0 1054.0
HKD2_k127_1342126_1 PFAM AMP-dependent synthetase and ligase K00666 - - 3.194e-277 881.0
HKD2_k127_1342126_10 Phage integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001027 274.0
HKD2_k127_1342126_11 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000399 245.0
HKD2_k127_1342126_12 Thiopurine S-methyltransferase (TPMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001281 236.0
HKD2_k127_1342126_13 phosphoribosyltransferases - - - 0.000000000000000000000000000000000000000000000000001897 207.0
HKD2_k127_1342126_14 ketosteroid isomerase - - - 0.0000000000000000000000000000000000000000000000001012 184.0
HKD2_k127_1342126_15 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000001606 166.0
HKD2_k127_1342126_16 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000001093 150.0
HKD2_k127_1342126_17 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000000000699 145.0
HKD2_k127_1342126_18 Evidence 2b Function of strongly homologous gene K07497 - - 0.0000000000000000000000000000004129 132.0
HKD2_k127_1342126_19 Protein of unknown function (DUF504) - - - 0.000000000000000000000000007332 113.0
HKD2_k127_1342126_2 AAA domain - - - 1.726e-257 818.0
HKD2_k127_1342126_20 AMP binding - - - 0.000000000001207 81.0
HKD2_k127_1342126_21 BON domain - - - 0.00000000003362 74.0
HKD2_k127_1342126_3 Putative methyltransferase - - - 5.943e-239 751.0
HKD2_k127_1342126_4 Phospholipase D. Active site motifs. K06132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 580.0
HKD2_k127_1342126_5 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 502.0
HKD2_k127_1342126_6 Dual specificity phosphatase, catalytic domain K01090 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 492.0
HKD2_k127_1342126_7 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 329.0
HKD2_k127_1342126_8 Helix-hairpin-helix domain K04477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 350.0
HKD2_k127_1342126_9 phosphatidate Cytidylyltransferase K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003518 283.0
HKD2_k127_1342180_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 4.118e-311 978.0
HKD2_k127_1342180_1 Aminotransferase K14260 - 2.6.1.2,2.6.1.66 1.369e-217 684.0
HKD2_k127_1342180_10 binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 374.0
HKD2_k127_1342180_11 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 365.0
HKD2_k127_1342180_12 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 358.0
HKD2_k127_1342180_13 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 333.0
HKD2_k127_1342180_14 molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001537 287.0
HKD2_k127_1342180_15 Transglycosylase SLT domain K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001611 288.0
HKD2_k127_1342180_16 Lysin motif K06194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003549 258.0
HKD2_k127_1342180_17 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000001034 250.0
HKD2_k127_1342180_18 plastoquinol--plastocyanin reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000003453 236.0
HKD2_k127_1342180_19 Protein of unknown function (DUF1631) - - - 0.00000000000000000000000000000000000000000000000000000000003168 218.0
HKD2_k127_1342180_2 homoserine dehydrogenase K00003 - 1.1.1.3 1.746e-205 648.0
HKD2_k127_1342180_20 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000001392 204.0
HKD2_k127_1342180_21 Peptidase C13 family - - - 0.000000000000000000000000000000000000000007783 172.0
HKD2_k127_1342180_22 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000001099 162.0
HKD2_k127_1342180_23 MaoC like domain - - - 0.0000000000000000000000000000000000000006032 163.0
HKD2_k127_1342180_24 Etoposide-induced protein 2.4 (EI24) - - - 0.000000000000000000000000000000001244 142.0
HKD2_k127_1342180_25 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000001255 131.0
HKD2_k127_1342180_26 Recombinase - - - 0.0000000000000000002832 94.0
HKD2_k127_1342180_27 - - - - 0.00000331 54.0
HKD2_k127_1342180_3 Threonine synthase K01733 - 4.2.3.1 1.806e-205 650.0
HKD2_k127_1342180_4 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 492.0
HKD2_k127_1342180_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 467.0
HKD2_k127_1342180_6 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009277 424.0
HKD2_k127_1342180_7 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 409.0
HKD2_k127_1342180_8 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 407.0
HKD2_k127_1342180_9 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 414.0
HKD2_k127_1403658_0 B12 binding domain K00548 - 2.1.1.13 0.0 1243.0
HKD2_k127_1403658_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 562.0
HKD2_k127_1403658_10 Rhodanese Homology Domain - - - 0.000007789 49.0
HKD2_k127_1403658_11 Protein of unknown function (DUF2934) - - - 0.00003125 52.0
HKD2_k127_1403658_2 Aminotransferase K14287 - 2.6.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 565.0
HKD2_k127_1403658_3 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 484.0
HKD2_k127_1403658_4 Pfam Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 467.0
HKD2_k127_1403658_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001872 257.0
HKD2_k127_1403658_6 Hydrolase, alpha beta domain protein K01066 - - 0.0000000000000000000000000000000000000000000000000000000000001193 224.0
HKD2_k127_1403658_7 2-keto-4-pentenoate hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000009295 223.0
HKD2_k127_1403658_8 Sortase family K07284 - 3.4.22.70 0.000000000000000000000000000000000000000003788 165.0
HKD2_k127_1403658_9 Belongs to the ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000000000003382 145.0
HKD2_k127_1408958_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 564.0
HKD2_k127_1408958_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 494.0
HKD2_k127_1408958_10 LTXXQ motif family protein - - - 0.000006619 55.0
HKD2_k127_1408958_2 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 331.0
HKD2_k127_1408958_3 DnaJ C terminal domain K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 349.0
HKD2_k127_1408958_4 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 324.0
HKD2_k127_1408958_5 PFAM Spermine synthase K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 289.0
HKD2_k127_1408958_6 aminopeptidase N - - - 0.00000000000000000000000000000000000000000000000000000000000002224 235.0
HKD2_k127_1408958_7 Dodecin K09165 - - 0.0000000000000000000000005203 121.0
HKD2_k127_1408958_8 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000183 97.0
HKD2_k127_1408958_9 MerR HTH family regulatory protein K18997 - - 0.0000006502 61.0
HKD2_k127_1443038_0 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 7.647e-320 1003.0
HKD2_k127_1443038_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 2.39e-233 731.0
HKD2_k127_1443038_10 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 321.0
HKD2_k127_1443038_11 dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001138 265.0
HKD2_k127_1443038_12 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000000000000000000000001045 221.0
HKD2_k127_1443038_13 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000001091 212.0
HKD2_k127_1443038_14 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000861 211.0
HKD2_k127_1443038_15 DoxX K15977 - - 0.00000000000000000000000000000000000000103 156.0
HKD2_k127_1443038_16 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.00000000000000009228 80.0
HKD2_k127_1443038_17 electron transfer activity K03737,K05337 - 1.2.7.1 0.00001132 59.0
HKD2_k127_1443038_2 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 2.267e-221 703.0
HKD2_k127_1443038_3 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 545.0
HKD2_k127_1443038_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 505.0
HKD2_k127_1443038_5 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 484.0
HKD2_k127_1443038_6 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 481.0
HKD2_k127_1443038_7 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 347.0
HKD2_k127_1443038_8 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 309.0
HKD2_k127_1443038_9 Two component transcriptional regulator, winged helix family K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 331.0
HKD2_k127_1470580_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006807,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0020037,GO:0042279,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0097164,GO:0098809,GO:1901363 1.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 581.0
HKD2_k127_1470580_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 500.0
HKD2_k127_1470580_10 HutD K09975 - - 0.0000000000000000000000000000000000002622 148.0
HKD2_k127_1470580_11 Putative prokaryotic signal transducing protein - - - 0.00000000000000005255 93.0
HKD2_k127_1470580_2 Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 479.0
HKD2_k127_1470580_3 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 462.0
HKD2_k127_1470580_4 Flavin containing amine oxidoreductase K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 374.0
HKD2_k127_1470580_5 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 324.0
HKD2_k127_1470580_6 Pfam Binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004042 278.0
HKD2_k127_1470580_7 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001486 274.0
HKD2_k127_1470580_8 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000003725 186.0
HKD2_k127_1470580_9 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000003473 171.0
HKD2_k127_153862_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000005442 248.0
HKD2_k127_153862_1 - - - - 0.00000000000000000000000000000000000000000000000000000378 200.0
HKD2_k127_153862_2 - - - - 0.000000000000000000000000000000003664 142.0
HKD2_k127_1539949_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1453.0
HKD2_k127_1539949_1 AcrB/AcrD/AcrF family K03296 - - 0.0 1126.0
HKD2_k127_1539949_10 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 402.0
HKD2_k127_1539949_11 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 395.0
HKD2_k127_1539949_12 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 353.0
HKD2_k127_1539949_13 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 361.0
HKD2_k127_1539949_14 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 321.0
HKD2_k127_1539949_15 FAD binding domain K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 312.0
HKD2_k127_1539949_16 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 312.0
HKD2_k127_1539949_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001786 279.0
HKD2_k127_1539949_18 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000004872 209.0
HKD2_k127_1539949_19 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors K12973 - 2.3.1.251 0.000000000000000000000000000000000000003711 153.0
HKD2_k127_1539949_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 1.412e-223 713.0
HKD2_k127_1539949_20 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.00000000000000000000000000000000004459 143.0
HKD2_k127_1539949_21 Alpha/beta hydrolase family - - - 0.0000000000000000000004805 111.0
HKD2_k127_1539949_22 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000002208 94.0
HKD2_k127_1539949_23 Bacterial regulatory protein, Fis family K03557 - - 0.0000000000000001096 93.0
HKD2_k127_1539949_24 - - - - 0.000000001822 69.0
HKD2_k127_1539949_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 2.802e-218 690.0
HKD2_k127_1539949_4 Dehydrogenase K00382 - 1.8.1.4 2.573e-199 632.0
HKD2_k127_1539949_5 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 8.306e-194 614.0
HKD2_k127_1539949_6 aminopeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 537.0
HKD2_k127_1539949_7 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 456.0
HKD2_k127_1539949_8 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 461.0
HKD2_k127_1539949_9 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 470.0
HKD2_k127_1580732_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 9.694e-217 683.0
HKD2_k127_1580732_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 371.0
HKD2_k127_1580732_2 Protein of unknown function (DUF2889) - - - 0.00000000000000000000000000000000000000000000000000000000000000004857 228.0
HKD2_k127_1580732_3 PFAM regulatory protein MarR - - - 0.0000000000000000000001052 101.0
HKD2_k127_160640_0 carboxylase K01969 - 6.4.1.4 5.817e-283 879.0
HKD2_k127_160640_1 poly(R)-hydroxyalkanoic acid synthase K03821 - - 6.695e-255 819.0
HKD2_k127_160640_10 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000000000000001648 214.0
HKD2_k127_160640_11 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000007404 186.0
HKD2_k127_160640_12 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000006253 178.0
HKD2_k127_160640_13 transcriptional - - - 0.0000000000000000000000000000000327 137.0
HKD2_k127_160640_14 Acetyl propionyl-CoA carboxylase alpha subunit K01968 - 6.4.1.4 0.00000000000000000000000002872 109.0
HKD2_k127_160640_15 PFAM MaoC domain protein dehydratase - - - 0.00000000000000000000000325 119.0
HKD2_k127_160640_16 protein conserved in bacteria K09984 - - 0.0000000000000000000001206 98.0
HKD2_k127_160640_17 Glycine zipper 2TM domain - - - 0.000000000000000000001409 98.0
HKD2_k127_160640_18 Glyoxalase-like domain - - - 0.00000000000001998 80.0
HKD2_k127_160640_2 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 5.439e-206 655.0
HKD2_k127_160640_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 588.0
HKD2_k127_160640_4 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 563.0
HKD2_k127_160640_5 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 370.0
HKD2_k127_160640_6 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 301.0
HKD2_k127_160640_7 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001352 296.0
HKD2_k127_160640_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005037 256.0
HKD2_k127_160640_9 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008589 228.0
HKD2_k127_1657277_0 Thi4 family - - - 1.028e-218 696.0
HKD2_k127_1657277_1 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 501.0
HKD2_k127_1657277_10 Belongs to the anti-sigma-factor antagonist family - - - 0.000000000000000000000000000000000000000001953 171.0
HKD2_k127_1657277_11 hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000005592 151.0
HKD2_k127_1657277_12 Protein of unknown function (DUF3025) - - - 0.000000000000000000000000000000003051 146.0
HKD2_k127_1657277_13 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000008308 126.0
HKD2_k127_1657277_14 Protein of unknown function (DUF4019) - - - 0.0000000000008356 81.0
HKD2_k127_1657277_2 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 472.0
HKD2_k127_1657277_3 tRNA wobble cytosine modification - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 419.0
HKD2_k127_1657277_4 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 367.0
HKD2_k127_1657277_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 315.0
HKD2_k127_1657277_6 Ubiquinone biosynthesis hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008803 324.0
HKD2_k127_1657277_7 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 282.0
HKD2_k127_1657277_8 Disulfide bond isomerase protein N-terminus K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000007099 244.0
HKD2_k127_1657277_9 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000269 198.0
HKD2_k127_1710712_0 amino acid K03758 - - 4.403e-228 712.0
HKD2_k127_1710712_1 Putative threonine/serine exporter - - - 0.00000000000000000000000000000000007478 143.0
HKD2_k127_173350_0 Pyridoxal-phosphate dependent enzyme K12339 GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 480.0
HKD2_k127_173350_1 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 458.0
HKD2_k127_173350_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 393.0
HKD2_k127_173350_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005674 347.0
HKD2_k127_173350_4 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 346.0
HKD2_k127_173350_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007022 338.0
HKD2_k127_173350_6 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000199 158.0
HKD2_k127_173350_7 Phenazine biosynthesis - - - 0.0000000000000000000000000008767 115.0
HKD2_k127_173350_8 Competence protein ComEA K02237 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.000000000000000000001798 108.0
HKD2_k127_173350_9 Competence protein ComEA K02237 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.00000000000000000001195 102.0
HKD2_k127_1737890_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 2.482e-225 711.0
HKD2_k127_1737890_1 Belongs to the HypD family K04654 - - 3.353e-199 634.0
HKD2_k127_1737890_2 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000000001697 118.0
HKD2_k127_1737890_3 hydrogenase expression formation protein HypE K04655 - - 0.000000000000148 79.0
HKD2_k127_1781301_0 FAD dependent oxidoreductase - - - 0.0 1096.0
HKD2_k127_1781301_1 Na Pi-cotransporter II-related protein K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 610.0
HKD2_k127_1781301_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005113 248.0
HKD2_k127_1781301_3 calcium- and calmodulin-responsive adenylate cyclase activity K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000005174 221.0
HKD2_k127_1781301_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000001188 136.0
HKD2_k127_1808896_0 Belongs to the glutaminase family K01425 - 3.5.1.2 8.178e-226 715.0
HKD2_k127_1808896_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 509.0
HKD2_k127_1808896_10 PFAM HNH endonuclease K07451 - - 0.0000000000000000000005898 104.0
HKD2_k127_1808896_11 - - - - 0.000000006274 58.0
HKD2_k127_1808896_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 471.0
HKD2_k127_1808896_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 458.0
HKD2_k127_1808896_4 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 439.0
HKD2_k127_1808896_5 a g-specific adenine glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 404.0
HKD2_k127_1808896_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009797 304.0
HKD2_k127_1808896_7 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000004148 205.0
HKD2_k127_1808896_8 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000003246 187.0
HKD2_k127_1808896_9 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000004835 141.0
HKD2_k127_1887536_0 cellulose binding - - - 2.096e-251 819.0
HKD2_k127_1887536_1 Rieske-like [2Fe-2S] domain - - - 1.509e-239 754.0
HKD2_k127_1887536_10 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 381.0
HKD2_k127_1887536_11 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 342.0
HKD2_k127_1887536_12 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 327.0
HKD2_k127_1887536_13 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 317.0
HKD2_k127_1887536_14 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000003108 276.0
HKD2_k127_1887536_15 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000001096 271.0
HKD2_k127_1887536_16 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001333 246.0
HKD2_k127_1887536_17 glycosyl transferase K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000002461 234.0
HKD2_k127_1887536_18 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000004252 196.0
HKD2_k127_1887536_19 Lactoylglutathione lyase - - - 0.0000000000000000000000000000000000000000000000000000007809 194.0
HKD2_k127_1887536_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 617.0
HKD2_k127_1887536_20 Belongs to the HpcH HpaI aldolase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000002061 193.0
HKD2_k127_1887536_21 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.00000000000000000000000000000000000000000000000007693 185.0
HKD2_k127_1887536_22 Nitrous oxide-stimulated promoter - - - 0.000000000000000000000000000000000001733 143.0
HKD2_k127_1887536_23 Cytochrome c - - - 0.00000000000000000000000000000000002347 147.0
HKD2_k127_1887536_24 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000003461 134.0
HKD2_k127_1887536_25 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000004137 109.0
HKD2_k127_1887536_26 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000007622 109.0
HKD2_k127_1887536_27 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' K03556 GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000006176 111.0
HKD2_k127_1887536_28 Transcriptional regulator - - - 0.0000000000001615 77.0
HKD2_k127_1887536_29 PGAP1-like protein - - - 0.00000000005635 65.0
HKD2_k127_1887536_3 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 611.0
HKD2_k127_1887536_30 Membrane transport protein K07088 - - 0.00000000248 62.0
HKD2_k127_1887536_4 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 556.0
HKD2_k127_1887536_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 526.0
HKD2_k127_1887536_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 522.0
HKD2_k127_1887536_7 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 503.0
HKD2_k127_1887536_8 Belongs to the LDH2 MDH2 oxidoreductase family K00016 - 1.1.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 394.0
HKD2_k127_1887536_9 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 386.0
HKD2_k127_194889_0 Mandelate racemase muconate lactonizing protein K01781,K20549 - 5.1.2.2,5.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007202 427.0
HKD2_k127_194889_1 Protein of unknown function (DUF808) K09781 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 380.0
HKD2_k127_194889_2 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 332.0
HKD2_k127_194889_3 Bacterial protein of unknown function (DUF924) - - - 0.000000000000000000000000000000000000000000000000000000002512 207.0
HKD2_k127_194889_4 DsrE/DsrF-like family K09004 - - 0.000000000008185 66.0
HKD2_k127_1990397_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1526.0
HKD2_k127_1990397_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 3.013e-274 852.0
HKD2_k127_1990397_10 Stress responsive A/B Barrel Domain - - - 0.0000000000000000000006452 109.0
HKD2_k127_1990397_2 Circularly permuted ATP-grasp type 2 - - - 1.155e-239 748.0
HKD2_k127_1990397_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 2.024e-219 692.0
HKD2_k127_1990397_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 595.0
HKD2_k127_1990397_5 Belongs to the KdsA family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 437.0
HKD2_k127_1990397_6 PFAM 20S proteasome, A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 334.0
HKD2_k127_1990397_7 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 341.0
HKD2_k127_1990397_8 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000000000005378 142.0
HKD2_k127_1990397_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000000000000000000000000000000001639 132.0
HKD2_k127_2348182_0 ABC transporter, ATP-binding protein K06020 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 430.0
HKD2_k127_2348182_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 293.0
HKD2_k127_2348182_2 mechanosensitive ion channel K05802 - - 0.00000000000000000000000000000000000000000000000000000000000000006017 251.0
HKD2_k127_2348182_3 Domain of unknown function (DUF4124) - - - 0.0000000000000000007618 96.0
HKD2_k127_2348182_4 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000002574 58.0
HKD2_k127_2361263_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 424.0
HKD2_k127_2361263_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000002048 87.0
HKD2_k127_2378312_0 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 544.0
HKD2_k127_2378312_1 Trap dicarboxylate transporter, dctm subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 482.0
HKD2_k127_2378312_2 Sugar (and other) transporter K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 317.0
HKD2_k127_2378312_3 Protein of unknown function (DUF533) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 303.0
HKD2_k127_2378312_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000001158 236.0
HKD2_k127_2378312_5 Tripartite ATP-independent periplasmic transporter, DctQ - - - 0.00000000000000000000000000000000000005148 149.0
HKD2_k127_2378312_6 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.000003172 49.0
HKD2_k127_2407766_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.11e-213 681.0
HKD2_k127_2407766_1 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 3.813e-203 637.0
HKD2_k127_2407766_10 - - - - 0.00000415 51.0
HKD2_k127_2407766_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 573.0
HKD2_k127_2407766_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007882 483.0
HKD2_k127_2407766_4 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 325.0
HKD2_k127_2407766_5 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002416 239.0
HKD2_k127_2407766_6 Tripartite ATP-independent periplasmic transporters, DctQ component K11689,K21394 - - 0.0000000000000000000000000000000000000000000000000000000000001153 220.0
HKD2_k127_2407766_7 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000001761 184.0
HKD2_k127_2407766_8 Malonate decarboxylase K13932 - 4.1.1.87 0.0000000000000000000000009914 119.0
HKD2_k127_2407766_9 Cell division protein ZapA K09888 - - 0.0000000000000000001069 97.0
HKD2_k127_243317_0 DNA replication, recombination, and repair K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 417.0
HKD2_k127_243317_1 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007902 334.0
HKD2_k127_243317_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000002081 59.0
HKD2_k127_2588622_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1167.0
HKD2_k127_2588622_1 Bacterial extracellular solute-binding proteins, family 5 Middle K12368 - - 7.426e-302 930.0
HKD2_k127_2588622_10 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 6.423e-202 638.0
HKD2_k127_2588622_11 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 613.0
HKD2_k127_2588622_12 DAHP synthetase I family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 602.0
HKD2_k127_2588622_13 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 627.0
HKD2_k127_2588622_14 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 602.0
HKD2_k127_2588622_15 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 550.0
HKD2_k127_2588622_16 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 510.0
HKD2_k127_2588622_17 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 501.0
HKD2_k127_2588622_18 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 526.0
HKD2_k127_2588622_19 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 507.0
HKD2_k127_2588622_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.335e-294 938.0
HKD2_k127_2588622_20 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 481.0
HKD2_k127_2588622_21 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 479.0
HKD2_k127_2588622_22 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 467.0
HKD2_k127_2588622_23 Belongs to the ABC transporter superfamily K12372 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 477.0
HKD2_k127_2588622_24 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 466.0
HKD2_k127_2588622_25 Peptidase M48 K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 465.0
HKD2_k127_2588622_26 TIGRFAM 3-oxoacid CoA-transferase, B subunit K01032 - 2.8.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 459.0
HKD2_k127_2588622_27 TRAP transporter solute receptor, TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 460.0
HKD2_k127_2588622_28 MCM2/3/5 family K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007453 451.0
HKD2_k127_2588622_29 oxidase, subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 461.0
HKD2_k127_2588622_3 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.575e-293 914.0
HKD2_k127_2588622_30 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 440.0
HKD2_k127_2588622_31 Luciferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 424.0
HKD2_k127_2588622_32 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 393.0
HKD2_k127_2588622_33 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 369.0
HKD2_k127_2588622_34 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 357.0
HKD2_k127_2588622_35 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 356.0
HKD2_k127_2588622_36 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 329.0
HKD2_k127_2588622_37 Helix-turn-helix type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 325.0
HKD2_k127_2588622_38 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001028 289.0
HKD2_k127_2588622_39 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008558 274.0
HKD2_k127_2588622_4 TRAP transporter 4TM 12TM fusion - - - 1.211e-292 914.0
HKD2_k127_2588622_40 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000002331 276.0
HKD2_k127_2588622_41 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006867 263.0
HKD2_k127_2588622_42 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005443 256.0
HKD2_k127_2588622_43 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000000774 256.0
HKD2_k127_2588622_44 Alpha/beta hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000008561 244.0
HKD2_k127_2588622_45 Bacterial extracellular solute-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000005409 231.0
HKD2_k127_2588622_46 CHAD - - - 0.0000000000000000000000000000000000000000000000000000000000009537 231.0
HKD2_k127_2588622_47 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000000000000003586 198.0
HKD2_k127_2588622_48 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000401 187.0
HKD2_k127_2588622_49 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000009301 189.0
HKD2_k127_2588622_5 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.346e-255 799.0
HKD2_k127_2588622_50 Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000001867 185.0
HKD2_k127_2588622_51 Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000153 189.0
HKD2_k127_2588622_52 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000775 184.0
HKD2_k127_2588622_53 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000001039 182.0
HKD2_k127_2588622_54 Hsp20/alpha crystallin family - - - 0.00000000000000000000000000000000000000003713 157.0
HKD2_k127_2588622_55 Thioesterase superfamily K07107 - - 0.0000000000000000000000000000000000000001015 156.0
HKD2_k127_2588622_56 Glycine-zipper domain - - - 0.0000000000000000000000000000000000000006997 163.0
HKD2_k127_2588622_57 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000000000000002022 130.0
HKD2_k127_2588622_58 Domain of unknown function (DUF1850) - - - 0.00000000000000000000000000003992 120.0
HKD2_k127_2588622_59 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000003134 122.0
HKD2_k127_2588622_6 PFAM electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 3.803e-238 750.0
HKD2_k127_2588622_60 Cytochrome c - - - 0.0000000000000000000000004554 109.0
HKD2_k127_2588622_61 dksA traR - - - 0.0000000000000000000000419 104.0
HKD2_k127_2588622_62 PFAM PsiF repeat protein - - - 0.0000000000000000004135 93.0
HKD2_k127_2588622_63 KTSC domain - - - 0.0000000000000000006021 89.0
HKD2_k127_2588622_64 - - - - 0.0000000000000003436 91.0
HKD2_k127_2588622_65 - - - - 0.0000000003317 69.0
HKD2_k127_2588622_66 response regulator - - - 0.00000003199 62.0
HKD2_k127_2588622_67 - - - - 0.0000003598 62.0
HKD2_k127_2588622_68 Acetyltransferase (GNAT) domain - - - 0.000001476 60.0
HKD2_k127_2588622_69 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0005866 53.0
HKD2_k127_2588622_7 asparaginyl-tRNA synthetase K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 6.222e-232 725.0
HKD2_k127_2588622_8 oxidase subunit I K00425 - 1.10.3.14 2.315e-212 671.0
HKD2_k127_2588622_9 Receptor family ligand binding region K01999 - - 1.189e-209 659.0
HKD2_k127_2593638_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 2.278e-212 668.0
HKD2_k127_2593638_1 Male sterility protein K02473 - 5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 476.0
HKD2_k127_2593638_2 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 287.0
HKD2_k127_2593638_3 lytic transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 292.0
HKD2_k127_2593638_4 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000006596 219.0
HKD2_k127_2595874_0 Alpha-amylase domain K01187 - 3.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 325.0
HKD2_k127_2595874_1 PFAM Conserved TM helix repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000268 253.0
HKD2_k127_2595874_2 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000002276 241.0
HKD2_k127_2596432_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 456.0
HKD2_k127_2596432_1 Catalyzes the sodium-dependent transport of glutamate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 374.0
HKD2_k127_2596432_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 335.0
HKD2_k127_2596432_3 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 324.0
HKD2_k127_2596432_4 Dihydrodipicolinate synthetase family K13876 - 4.2.1.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 302.0
HKD2_k127_2596432_5 TRAP transporter solute receptor TAXI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003207 277.0
HKD2_k127_2596432_6 PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - 0.000000002905 64.0
HKD2_k127_2597114_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 2.893e-226 711.0
HKD2_k127_2597114_1 amino acid transport system, periplasmic component K01999 - - 6.155e-194 616.0
HKD2_k127_2597114_2 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 565.0
HKD2_k127_2597114_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 527.0
HKD2_k127_2597114_4 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 450.0
HKD2_k127_2597114_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 441.0
HKD2_k127_2597114_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007025 265.0
HKD2_k127_2597114_7 SMART cyclic nucleotide-binding K10914 - - 0.000000000000000000000000000000000000000000000000000000005379 206.0
HKD2_k127_2597114_8 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000005251 192.0
HKD2_k127_2597114_9 YjbR - - - 0.0000000000000000000000001348 111.0
HKD2_k127_2630392_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1444.0
HKD2_k127_2630392_1 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 529.0
HKD2_k127_2630392_10 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000001605 199.0
HKD2_k127_2630392_11 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000003604 173.0
HKD2_k127_2630392_12 Cytochrome B561 - - - 0.000000000000000000000000000000000000000000004424 174.0
HKD2_k127_2630392_13 PFAM cytochrome c - - - 0.000000000000000000000000000000001181 135.0
HKD2_k127_2630392_14 effector of murein hydrolase LrgA K06518 - - 0.00000000000000000000000597 109.0
HKD2_k127_2630392_15 Response regulator receiver - - - 0.000000000000000000001549 101.0
HKD2_k127_2630392_17 Protein of unknown function (DUF465) - - - 0.00000000007764 73.0
HKD2_k127_2630392_18 - - - - 0.000000002878 71.0
HKD2_k127_2630392_2 Protein of unknown function (DUF3141) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 486.0
HKD2_k127_2630392_20 Bacterioferritin K03594 - 1.16.3.1 0.00002406 56.0
HKD2_k127_2630392_21 Bacterial protein of unknown function (DUF883) - GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944 - 0.00005287 50.0
HKD2_k127_2630392_3 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 376.0
HKD2_k127_2630392_4 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 294.0
HKD2_k127_2630392_5 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000384 293.0
HKD2_k127_2630392_6 PFAM LrgB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006625 274.0
HKD2_k127_2630392_7 Solute carrier family 35 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001353 281.0
HKD2_k127_2630392_8 histidine kinase, dimerisation and phosphoacceptor region K05962 - 2.7.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000005592 273.0
HKD2_k127_2630392_9 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001588 258.0
HKD2_k127_2643314_0 lipoprotein releasing system, transmembrane protein, LolC E family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 369.0
HKD2_k127_2643314_1 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 313.0
HKD2_k127_2648985_0 oxidoreductase activity - - - 0.0 1092.0
HKD2_k127_2648985_1 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 592.0
HKD2_k127_2648985_2 Belongs to the DapA family K01714,K13876 - 4.2.1.43,4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 481.0
HKD2_k127_2648985_3 Lanthionine synthetase C-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 301.0
HKD2_k127_2648985_4 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002447 262.0
HKD2_k127_2648985_5 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000002496 184.0
HKD2_k127_2648985_6 - - - - 0.0000000000000000000000000003006 119.0
HKD2_k127_2671966_0 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 415.0
HKD2_k127_2671966_1 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006303 291.0
HKD2_k127_2671966_2 4Fe-4S dicluster domain - - - 0.00000000000000007 87.0
HKD2_k127_2705274_0 lyase activity K11645 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 571.0
HKD2_k127_2705274_1 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 526.0
HKD2_k127_2705274_2 Beta/gamma crystallins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002796 253.0
HKD2_k127_2705274_3 Protein of unknown function (DUF3750) - - - 0.00000000000000000000000000000000000000000000000000000000000000000005812 248.0
HKD2_k127_2705274_4 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.00000000000000000000000000000000000000000000000000003623 189.0
HKD2_k127_2705274_5 PFAM Thioredoxin domain K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000002285 175.0
HKD2_k127_2705274_6 redox protein, regulator of disulfide bond formation - - - 0.00000000000000000000000000000000000000001138 164.0
HKD2_k127_2705274_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000005371 156.0
HKD2_k127_2705274_8 - - - - 0.0000000000000000000000000000001964 133.0
HKD2_k127_2705274_9 cyclic nucleotide binding K00384,K10914 - 1.8.1.9 0.0000000000000000000000000000009457 127.0
HKD2_k127_2727071_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons - - - 3.246e-223 731.0
HKD2_k127_2727071_1 PFAM acyl-CoA dehydrogenase domain protein K00249,K07545 - 1.3.8.3,1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 543.0
HKD2_k127_2727071_10 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002129 285.0
HKD2_k127_2727071_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000001386 252.0
HKD2_k127_2727071_12 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000008693 256.0
HKD2_k127_2727071_13 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000003837 228.0
HKD2_k127_2727071_14 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000006103 231.0
HKD2_k127_2727071_15 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000008447 205.0
HKD2_k127_2727071_2 Oxidoreductase family, NAD-binding Rossmann fold K19181 - 1.1.1.292 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 421.0
HKD2_k127_2727071_3 Oxidoreductase family, NAD-binding Rossmann fold K19181 - 1.1.1.292 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 393.0
HKD2_k127_2727071_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 357.0
HKD2_k127_2727071_5 Enoyl-CoA hydratase/isomerase K08299 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 334.0
HKD2_k127_2727071_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 329.0
HKD2_k127_2727071_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 314.0
HKD2_k127_2727071_8 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 307.0
HKD2_k127_2727071_9 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 297.0
HKD2_k127_2763804_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 419.0
HKD2_k127_2763804_1 (Lipo)protein K07287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 334.0
HKD2_k127_2763804_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 319.0
HKD2_k127_2763804_3 cobalamin biosynthetic process K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 317.0
HKD2_k127_2763804_4 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000008374 227.0
HKD2_k127_2768833_0 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 4.454e-232 727.0
HKD2_k127_2768833_1 TIGRFAM arginyl-tRNA synthetase K01887 - 6.1.1.19 3.949e-210 666.0
HKD2_k127_2768833_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 600.0
HKD2_k127_2768833_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 472.0
HKD2_k127_2768833_4 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 312.0
HKD2_k127_2768833_5 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000000001205 181.0
HKD2_k127_2768833_6 Sporulation related domain - - - 0.000000000000000000000007071 112.0
HKD2_k127_2768833_7 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0000005554 51.0
HKD2_k127_2789336_0 Asparagine synthase K01953 - 6.3.5.4 2.476e-318 989.0
HKD2_k127_2789336_1 PEP-CTERM exosortase 1-associated glycosyltransferase, Daro_2409 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 573.0
HKD2_k127_2789336_2 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000599 232.0
HKD2_k127_2789336_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000001555 165.0
HKD2_k127_2848185_0 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 376.0
HKD2_k127_2848185_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 353.0
HKD2_k127_2848185_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 329.0
HKD2_k127_2848185_3 Histidine kinase - - - 0.000000000008338 80.0
HKD2_k127_2857054_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 8.304e-294 921.0
HKD2_k127_2857054_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 1.547e-195 612.0
HKD2_k127_2857054_10 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000001594 170.0
HKD2_k127_2857054_11 oxidation protein K17227 - - 0.00000000000000000000000000000000000000000002808 163.0
HKD2_k127_2857054_12 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000005376 160.0
HKD2_k127_2857054_13 intradiol ring-cleavage dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000000003896 174.0
HKD2_k127_2857054_14 DsrE/DsrF-like family K09004 - - 0.0000000000000000000000000000000000000339 152.0
HKD2_k127_2857054_15 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000006523 140.0
HKD2_k127_2857054_16 acetyltransferase K03825 - - 0.0000000000000000000000000000002392 136.0
HKD2_k127_2857054_17 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000004178 136.0
HKD2_k127_2857054_18 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797 - 2.5.1.16 0.0000000000000000000000009195 111.0
HKD2_k127_2857054_19 Transglycosylase associated protein - - - 0.000000000000000000001838 102.0
HKD2_k127_2857054_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 628.0
HKD2_k127_2857054_20 5'-nucleotidase, C-terminal domain K17224 - - 0.00003726 47.0
HKD2_k127_2857054_3 catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 608.0
HKD2_k127_2857054_4 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 534.0
HKD2_k127_2857054_5 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 393.0
HKD2_k127_2857054_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 326.0
HKD2_k127_2857054_7 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001383 274.0
HKD2_k127_2857054_8 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000000000000000000000000000000000001944 201.0
HKD2_k127_2857054_9 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000008436 188.0
HKD2_k127_2877436_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 347.0
HKD2_k127_2877436_1 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 309.0
HKD2_k127_2877436_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759,K05606 - 4.4.1.5,5.1.99.1 0.00000000000000000000000000000000000003155 160.0
HKD2_k127_2877436_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000003895 141.0
HKD2_k127_291878_0 CHASE2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 498.0
HKD2_k127_291878_1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 421.0
HKD2_k127_291878_2 OmpA family - - - 0.000000000000000000000000000000000000001811 154.0
HKD2_k127_291878_3 FecR protein - - - 0.00000000000000000000000000000000002467 138.0
HKD2_k127_291878_4 STAS domain K06378 - - 0.0000000000000000004999 92.0
HKD2_k127_2932633_0 Respiratory nitrate reductase alpha N-terminal K00370 - 1.7.5.1 0.0 1242.0
HKD2_k127_2932633_1 4Fe-4S dicluster domain K00371 - 1.7.5.1 2.555e-270 839.0
HKD2_k127_2932633_10 - - - - 0.00000000000002061 86.0
HKD2_k127_2932633_2 Belongs to the IlvD Edd family K13875 - 4.2.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007016 357.0
HKD2_k127_2932633_3 PDZ domain (Also known as DHR or GLGF) K08372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 342.0
HKD2_k127_2932633_4 Nitrate reductase K00374 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 316.0
HKD2_k127_2932633_5 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 282.0
HKD2_k127_2932633_6 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001143 288.0
HKD2_k127_2932633_7 peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000001208 209.0
HKD2_k127_2932633_8 Nitrate reductase, delta subunit K00373 - - 0.00000000000000000000000000000000000000000000009405 190.0
HKD2_k127_2932633_9 Protein of unknown function (DUF1282) - - - 0.000000000000000000000000000000000000004409 154.0
HKD2_k127_2958901_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 9.937e-216 699.0
HKD2_k127_2958901_1 PFAM Transketolase central region K21417 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 547.0
HKD2_k127_2958901_10 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.00000000000000000000000000000000000000000000000000000000000000000006061 255.0
HKD2_k127_2958901_11 sodium ABC transporter, permease K09696 - - 0.000000000000000000000000000000000000000000000000000000000000004081 231.0
HKD2_k127_2958901_12 COG2755 Lysophospholipase L1 and related esterases K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000001517 228.0
HKD2_k127_2958901_13 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000533 209.0
HKD2_k127_2958901_14 PFAM globin K06886 - - 0.00000000000000000000000000000000000000000002173 171.0
HKD2_k127_2958901_15 Cupredoxin-like domain - - - 0.00000000000000000000003104 102.0
HKD2_k127_2958901_16 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000146 62.0
HKD2_k127_2958901_2 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 529.0
HKD2_k127_2958901_3 PFAM alpha beta hydrolase fold K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 421.0
HKD2_k127_2958901_4 PFAM ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 328.0
HKD2_k127_2958901_5 Rhodanese Homology Domain K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 325.0
HKD2_k127_2958901_6 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 300.0
HKD2_k127_2958901_7 Iron permease K07243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 298.0
HKD2_k127_2958901_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 304.0
HKD2_k127_2958901_9 abc transporter atp-binding protein K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 292.0
HKD2_k127_3053380_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 2.456e-303 936.0
HKD2_k127_3053380_1 HELICc2 K03722 - 3.6.4.12 7.928e-233 741.0
HKD2_k127_3053380_10 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000134 152.0
HKD2_k127_3053380_11 GYD domain - - - 0.000000000000000000000000002139 127.0
HKD2_k127_3053380_12 Psort location Cytoplasmic, score 8.96 K07462 - - 0.0007844 42.0
HKD2_k127_3053380_2 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 590.0
HKD2_k127_3053380_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 441.0
HKD2_k127_3053380_4 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 354.0
HKD2_k127_3053380_5 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 369.0
HKD2_k127_3053380_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 308.0
HKD2_k127_3053380_7 ZIP Zinc transporter K16267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000131 252.0
HKD2_k127_3053380_8 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000002005 213.0
HKD2_k127_3053380_9 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000001354 163.0
HKD2_k127_307953_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.304e-280 871.0
HKD2_k127_307953_1 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 557.0
HKD2_k127_307953_10 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000003009 147.0
HKD2_k127_307953_11 ThiS family K03636 - - 0.0000000000000008517 81.0
HKD2_k127_307953_12 ATP synthase I chain K02116 - - 0.00000000000133 73.0
HKD2_k127_307953_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 380.0
HKD2_k127_307953_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 370.0
HKD2_k127_307953_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 330.0
HKD2_k127_307953_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 292.0
HKD2_k127_307953_6 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000001062 260.0
HKD2_k127_307953_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.00000000000000000000000000000000000000000000003801 175.0
HKD2_k127_307953_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000009791 151.0
HKD2_k127_307953_9 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000005177 135.0
HKD2_k127_3169314_0 DNA polymerase X family K02347 - - 8.307e-233 743.0
HKD2_k127_3169314_1 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 484.0
HKD2_k127_3169314_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 404.0
HKD2_k127_3169314_3 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 338.0
HKD2_k127_3169314_4 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.000000000000000000000000008596 119.0
HKD2_k127_3169314_5 ErfK YbiS YcfS YnhG family protein K21470 - - 0.000000001246 70.0
HKD2_k127_3169317_0 Hexapeptide repeat of succinyl-transferase K13018 - 2.3.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 418.0
HKD2_k127_3169317_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 391.0
HKD2_k127_3169317_2 Belongs to the DegT DnrJ EryC1 family K02805,K18653 - 2.6.1.104,2.6.1.59 0.00000000000000000000000000000000000000000000000003184 181.0
HKD2_k127_3169317_3 membrane - - - 0.0000000000000000005499 91.0
HKD2_k127_3220368_0 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 1.838e-307 955.0
HKD2_k127_3220368_1 ERAP1-like C-terminal domain K01263 - 3.4.11.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 453.0
HKD2_k127_3235002_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 1.262e-219 697.0
HKD2_k127_3235002_1 ABC transporter K06158 - - 1.704e-214 685.0
HKD2_k127_3235002_2 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 2.625e-211 675.0
HKD2_k127_3235002_3 AmpG muropeptide MFS transporter K08218 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 595.0
HKD2_k127_3235002_4 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 352.0
HKD2_k127_3235002_5 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000002197 232.0
HKD2_k127_3235002_6 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000002968 124.0
HKD2_k127_3235002_7 PTS HPr component phosphorylation site - - - 0.0000000000000001071 85.0
HKD2_k127_3417164_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1414.0
HKD2_k127_3417164_1 Glucose / Sorbosone dehydrogenase - - - 1.805e-224 701.0
HKD2_k127_3417164_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
HKD2_k127_3417164_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000006093 204.0
HKD2_k127_3417164_4 Cytochrome c - - - 0.000000000000000000003822 108.0
HKD2_k127_3549893_0 TIGRFAM glutamine synthetase, type I K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 554.0
HKD2_k127_3549893_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 455.0
HKD2_k127_3549893_2 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 376.0
HKD2_k127_3549893_3 Domain of unknown function (DUF4124) - - - 0.000000000004099 75.0
HKD2_k127_366703_0 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 507.0
HKD2_k127_366703_1 Soluble lytic murein transglycosylase L domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 497.0
HKD2_k127_366703_10 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000009386 218.0
HKD2_k127_366703_11 Gram-negative porin - - - 0.000000000000000000000000000000000000000000000668 180.0
HKD2_k127_366703_12 - - - - 0.000000000000000000000000000000000000000007115 179.0
HKD2_k127_366703_13 Gram-negative porin - - - 0.000000000000000000000000000000004395 142.0
HKD2_k127_366703_14 Protein of unknown function (DUF1289) K06938 - - 0.0000000000000007366 79.0
HKD2_k127_366703_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 474.0
HKD2_k127_366703_3 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007774 451.0
HKD2_k127_366703_4 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 451.0
HKD2_k127_366703_5 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 399.0
HKD2_k127_366703_6 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 316.0
HKD2_k127_366703_7 NAD-dependent epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 314.0
HKD2_k127_366703_8 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007965 256.0
HKD2_k127_366703_9 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000003854 241.0
HKD2_k127_370481_0 Tricorn protease homolog K08676 - - 9.391e-200 640.0
HKD2_k127_370481_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008555 259.0
HKD2_k127_370481_2 TraB family K09973 - - 0.0000000000000000000000000000000000000005429 162.0
HKD2_k127_370481_3 Copper chaperone PCu(A)C K09796 - - 0.00001771 48.0
HKD2_k127_3837401_0 ribonuclease BN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 351.0
HKD2_k127_3837401_1 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001132 274.0
HKD2_k127_3837401_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001298 271.0
HKD2_k127_3837401_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000007929 197.0
HKD2_k127_3837401_4 Cysteine-rich CWC - - - 0.00000000000001809 76.0
HKD2_k127_3848202_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 504.0
HKD2_k127_3848202_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 344.0
HKD2_k127_3848202_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000002285 175.0
HKD2_k127_3848202_3 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000000008496 170.0
HKD2_k127_3848202_4 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000000000000000000000008544 167.0
HKD2_k127_3848202_5 FR47-like protein - - - 0.0000000000000000000000000000000000002065 153.0
HKD2_k127_3848202_6 transcriptional regulator - - - 0.000000000000000000000000000000000006802 145.0
HKD2_k127_3867810_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 1.793e-216 692.0
HKD2_k127_3867810_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 3.985e-216 687.0
HKD2_k127_3880344_0 RNA secondary structure unwinding K03724 - - 2.962e-296 936.0
HKD2_k127_3880344_1 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 362.0
HKD2_k127_3880344_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 357.0
HKD2_k127_3880344_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 301.0
HKD2_k127_3880344_4 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000642 224.0
HKD2_k127_3880344_5 protein import - - - 0.00000000000000000000000002415 123.0
HKD2_k127_3880344_6 Subtilase family - - - 0.000000000000001148 90.0
HKD2_k127_3888514_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 469.0
HKD2_k127_3888514_1 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 292.0
HKD2_k127_3888514_2 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000000000000001005 173.0
HKD2_k127_3906549_0 Acts as a magnesium transporter K06213 - - 4.56e-199 631.0
HKD2_k127_3906549_1 RNB K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 589.0
HKD2_k127_3906549_2 NADH flavin oxidoreductase NADH oxidase K10680 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 535.0
HKD2_k127_3906549_3 TIGRFAM TRAP dicarboxylate transporter, DctP subunit K21395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 488.0
HKD2_k127_3906549_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 317.0
HKD2_k127_3906549_5 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 303.0
HKD2_k127_3906549_6 TIGRFAM TonB family protein K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001926 287.0
HKD2_k127_3906549_7 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000001005 151.0
HKD2_k127_3906549_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.000000000000000000000000000000000000001221 161.0
HKD2_k127_3906549_9 - - - - 0.00000000000000000000000001591 116.0
HKD2_k127_3918810_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007497 552.0
HKD2_k127_3918810_1 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 528.0
HKD2_k127_3918810_10 Lysin motif - - - 0.00000000000000000000000000000004051 139.0
HKD2_k127_3918810_11 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000007706 121.0
HKD2_k127_3918810_12 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000001499 89.0
HKD2_k127_3918810_2 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 515.0
HKD2_k127_3918810_3 PFAM Protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 516.0
HKD2_k127_3918810_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 425.0
HKD2_k127_3918810_5 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 406.0
HKD2_k127_3918810_6 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000034 297.0
HKD2_k127_3918810_7 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001661 275.0
HKD2_k127_3918810_8 Lysophospholipase L1 and related esterases K01073 - 3.1.2.20 0.0000000000000000000000000000000000000000000000008109 182.0
HKD2_k127_3918810_9 Acid phosphatase homologues - - - 0.0000000000000000000000000000000000000098 156.0
HKD2_k127_3929715_0 glucuronate isomerase K01812 - 5.3.1.12 1.444e-230 727.0
HKD2_k127_3929715_1 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 612.0
HKD2_k127_3929715_10 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000002565 228.0
HKD2_k127_3929715_11 FCD - - - 0.00000000000000000000000000000000000000000000000000001018 199.0
HKD2_k127_3929715_12 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000007404 106.0
HKD2_k127_3929715_13 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000002237 69.0
HKD2_k127_3929715_14 PFAM Cupin 2, conserved barrel domain protein - - - 0.00004089 51.0
HKD2_k127_3929715_2 Mannitol dehydrogenase Rossmann domain K00040 - 1.1.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 517.0
HKD2_k127_3929715_3 abc transporter K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 451.0
HKD2_k127_3929715_4 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 422.0
HKD2_k127_3929715_5 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 421.0
HKD2_k127_3929715_6 peptidase m48, ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 432.0
HKD2_k127_3929715_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 400.0
HKD2_k127_3929715_8 abc transporter K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 321.0
HKD2_k127_3929715_9 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005756 254.0
HKD2_k127_3934396_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 4.021e-317 976.0
HKD2_k127_3934396_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848,K20906 - 5.4.99.2,5.4.99.64 9.477e-291 902.0
HKD2_k127_3934396_10 Cytochrome c oxidase, subunit K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 379.0
HKD2_k127_3934396_11 ArgK protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 361.0
HKD2_k127_3934396_12 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 336.0
HKD2_k127_3934396_13 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 336.0
HKD2_k127_3934396_14 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 291.0
HKD2_k127_3934396_15 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006203 303.0
HKD2_k127_3934396_16 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003321 282.0
HKD2_k127_3934396_17 PFAM 20S proteasome, A and B subunits K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001688 253.0
HKD2_k127_3934396_18 RNA polymerase K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001861 248.0
HKD2_k127_3934396_19 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007562 228.0
HKD2_k127_3934396_2 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 1.968e-267 831.0
HKD2_k127_3934396_20 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000111 208.0
HKD2_k127_3934396_21 COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) K01849,K20907 - 5.4.99.2,5.4.99.64 0.00000000000000000000000000000000000000000000000000000001301 202.0
HKD2_k127_3934396_22 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000001684 213.0
HKD2_k127_3934396_23 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000003717 206.0
HKD2_k127_3934396_24 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000002035 185.0
HKD2_k127_3934396_25 regulatory protein GntR HTH - - - 0.000000000000000000000000000000000000000000000001719 187.0
HKD2_k127_3934396_26 B12 binding domain K22491 - - 0.0000000000000000000000000000000000000000005075 175.0
HKD2_k127_3934396_27 - - - - 0.0000000000000000000000000000000000000007141 168.0
HKD2_k127_3934396_28 universal stress protein - - - 0.0000000000000000000000000000000000001581 146.0
HKD2_k127_3934396_29 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000003849 150.0
HKD2_k127_3934396_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.262e-252 794.0
HKD2_k127_3934396_30 - - - - 0.000000000000000000000000000000004367 139.0
HKD2_k127_3934396_31 FixH family K09926 - - 0.0000000000000000000000000007061 131.0
HKD2_k127_3934396_32 PFAM RNA-binding S4 domain protein K04762 - - 0.000000000000000000000000007143 117.0
HKD2_k127_3934396_33 Protein of unknown function (DUF3106) - - - 0.00000000000000000000000001322 124.0
HKD2_k127_3934396_34 ACT domain K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000333 126.0
HKD2_k127_3934396_35 - - - - 0.000000000000000000000007813 112.0
HKD2_k127_3934396_36 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000983 111.0
HKD2_k127_3934396_37 - - - - 0.000000000000000000000601 109.0
HKD2_k127_3934396_38 PFAM RDD domain containing protein - - - 0.0000000000000000004125 94.0
HKD2_k127_3934396_39 cytochrome oxidase maturation protein cbb3-type - - - 0.0000000000002844 74.0
HKD2_k127_3934396_4 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 6.143e-249 782.0
HKD2_k127_3934396_40 Protein of unknown function (DUF3619) - - - 0.000000000003901 78.0
HKD2_k127_3934396_41 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000001439 76.0
HKD2_k127_3934396_42 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0000003013 54.0
HKD2_k127_3934396_5 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 2.962e-240 751.0
HKD2_k127_3934396_6 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 3.412e-231 728.0
HKD2_k127_3934396_7 cation transport ATPase K01533 - 3.6.3.4 5.104e-215 695.0
HKD2_k127_3934396_8 cytochrome C oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 615.0
HKD2_k127_3934396_9 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 471.0
HKD2_k127_3958915_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1401.0
HKD2_k127_3958915_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 3.594e-314 970.0
HKD2_k127_3958915_10 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 363.0
HKD2_k127_3958915_11 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009599 373.0
HKD2_k127_3958915_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 370.0
HKD2_k127_3958915_13 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 332.0
HKD2_k127_3958915_14 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 304.0
HKD2_k127_3958915_15 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008144 308.0
HKD2_k127_3958915_16 UTRA K03710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 286.0
HKD2_k127_3958915_17 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000004073 233.0
HKD2_k127_3958915_18 Cobyrinic acid ac-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000002073 224.0
HKD2_k127_3958915_19 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000006756 209.0
HKD2_k127_3958915_2 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.769e-234 743.0
HKD2_k127_3958915_20 Protein of unknown function (DUF3617) - - - 0.000000000000000000000000000000000000000000002697 169.0
HKD2_k127_3958915_21 Succinate dehydrogenase, hydrophobic K00242 - - 0.0000000000000000000000000000000008685 137.0
HKD2_k127_3958915_22 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000000000001557 126.0
HKD2_k127_3958915_23 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000007521 79.0
HKD2_k127_3958915_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 546.0
HKD2_k127_3958915_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 538.0
HKD2_k127_3958915_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 504.0
HKD2_k127_3958915_6 succinate dehydrogenase fumarate reductase K00240 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 426.0
HKD2_k127_3958915_7 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 420.0
HKD2_k127_3958915_8 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate K01815 - 5.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008812 396.0
HKD2_k127_3958915_9 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 366.0
HKD2_k127_3973339_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.441e-197 617.0
HKD2_k127_3973339_1 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000003811 220.0
HKD2_k127_3973339_2 Protein of unknown function (DUF4019) - - - 0.0000000000000000000009154 110.0
HKD2_k127_399505_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 2.328e-212 680.0
HKD2_k127_399505_1 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 413.0
HKD2_k127_399505_2 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 336.0
HKD2_k127_399505_3 Belongs to the helicase family. UvrD subfamily K03582 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000002045 199.0
HKD2_k127_399505_4 Domain of unknown function (DUF1330) - - - 0.00000000000001334 76.0
HKD2_k127_399505_5 DnaJ-class molecular chaperone with C-terminal Zn finger domain K03686 - - 0.00000002714 61.0
HKD2_k127_3996119_0 phenylacetic acid degradation protein paaN - - - 4.173e-262 819.0
HKD2_k127_3996119_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.146e-210 662.0
HKD2_k127_3996119_10 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000009726 240.0
HKD2_k127_3996119_11 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000006249 241.0
HKD2_k127_3996119_12 phenylacetate-CoA oxygenase, PaaJ subunit K02612 GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000001494 217.0
HKD2_k127_3996119_13 - - - - 0.0000000000000000000000000000000000000000000000000000000003568 220.0
HKD2_k127_3996119_14 Phenylacetic acid degradation protein K02614 GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 - 0.0000000000000000000000000000000000000000000000000000002143 198.0
HKD2_k127_3996119_15 Phenylacetic acid degradation B K02610 - - 0.00000000000000000000000000000000000000000000000000008722 186.0
HKD2_k127_3996119_2 Aminotransferase K09758 - 4.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 550.0
HKD2_k127_3996119_3 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 544.0
HKD2_k127_3996119_4 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 469.0
HKD2_k127_3996119_5 Oxidoreductase FAD-binding domain K02613 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 470.0
HKD2_k127_3996119_6 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 388.0
HKD2_k127_3996119_7 phenylacetic acid K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 337.0
HKD2_k127_3996119_8 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 340.0
HKD2_k127_3996119_9 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 317.0
HKD2_k127_3999776_0 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 0.0 1074.0
HKD2_k127_3999776_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 6.065e-296 926.0
HKD2_k127_3999776_10 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 383.0
HKD2_k127_3999776_11 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 302.0
HKD2_k127_3999776_12 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 297.0
HKD2_k127_3999776_13 Histidine kinase K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004911 297.0
HKD2_k127_3999776_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006687 281.0
HKD2_k127_3999776_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000107 269.0
HKD2_k127_3999776_16 response regulator K02483,K07666,K07774 - - 0.0000000000000000000000000000000000000000000000000000000001293 225.0
HKD2_k127_3999776_17 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000001095 204.0
HKD2_k127_3999776_18 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000001651 194.0
HKD2_k127_3999776_19 -Thioesterase K01075 - 3.1.2.23 0.00000000000000000000000000000000000000000001741 168.0
HKD2_k127_3999776_2 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 1.706e-279 906.0
HKD2_k127_3999776_20 diguanylate cyclase - - - 0.000000000000000000000000000000000000000007235 166.0
HKD2_k127_3999776_21 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000002947 166.0
HKD2_k127_3999776_22 Protein of unknown function (DUF2783) - - - 0.0000000000000000004607 91.0
HKD2_k127_3999776_3 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 6.034e-231 728.0
HKD2_k127_3999776_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.968e-215 676.0
HKD2_k127_3999776_5 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 559.0
HKD2_k127_3999776_6 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 529.0
HKD2_k127_3999776_7 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 522.0
HKD2_k127_3999776_8 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 442.0
HKD2_k127_3999776_9 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 398.0
HKD2_k127_4000112_0 Required for chromosome condensation and partitioning K03529 - - 1.511e-297 951.0
HKD2_k127_4000112_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.502e-261 831.0
HKD2_k127_4000112_10 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.00000000000000000000000000000000000000000000000000000000009139 219.0
HKD2_k127_4000112_11 MarC family integral membrane protein - - - 0.00000000000000000000000000000000004041 141.0
HKD2_k127_4000112_2 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 529.0
HKD2_k127_4000112_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007062 461.0
HKD2_k127_4000112_4 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 467.0
HKD2_k127_4000112_5 Belongs to the ABC transporter superfamily K02032,K12372 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 449.0
HKD2_k127_4000112_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 433.0
HKD2_k127_4000112_7 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 382.0
HKD2_k127_4000112_8 Transcriptional regulator, LysR family K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 366.0
HKD2_k127_4000112_9 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004096 286.0
HKD2_k127_4006322_0 PFAM alanine racemase domain protein K19967 - 4.1.2.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 346.0
HKD2_k127_4006322_1 Integrase core domain - - - 0.00000000000000000000000000000000000000000002291 166.0
HKD2_k127_4015164_0 DNA polymerase III tau subunit V interacting with alpha K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 483.0
HKD2_k127_4015164_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 349.0
HKD2_k127_4015164_2 Creatinine amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002011 289.0
HKD2_k127_4018626_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 4.105e-288 902.0
HKD2_k127_4018626_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 3.526e-239 747.0
HKD2_k127_4018626_10 IPP transferase K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 354.0
HKD2_k127_4018626_11 gluconolactonase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 328.0
HKD2_k127_4018626_12 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 322.0
HKD2_k127_4018626_13 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 323.0
HKD2_k127_4018626_14 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 311.0
HKD2_k127_4018626_15 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 310.0
HKD2_k127_4018626_16 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002516 276.0
HKD2_k127_4018626_17 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002513 260.0
HKD2_k127_4018626_18 PFAM Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000000000000000008934 239.0
HKD2_k127_4018626_19 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000592 233.0
HKD2_k127_4018626_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 9.414e-204 638.0
HKD2_k127_4018626_20 of the drug metabolite transporter (DMT) superfamily K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000001806 235.0
HKD2_k127_4018626_21 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000003161 120.0
HKD2_k127_4018626_22 amine dehydrogenase activity K13730 - - 0.0000000000000000000000006393 115.0
HKD2_k127_4018626_23 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000008925 111.0
HKD2_k127_4018626_24 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000002939 88.0
HKD2_k127_4018626_25 GGDEF domain - - - 0.000000001191 72.0
HKD2_k127_4018626_26 Entericidin EcnA/B family - - - 0.0005888 46.0
HKD2_k127_4018626_3 DNA mismatch repair protein, C-terminal domain K03572 - - 8.029e-195 625.0
HKD2_k127_4018626_4 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 587.0
HKD2_k127_4018626_5 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 569.0
HKD2_k127_4018626_6 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 506.0
HKD2_k127_4018626_7 Acyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008981 412.0
HKD2_k127_4018626_8 LysM domain K08086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009374 436.0
HKD2_k127_4018626_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 370.0
HKD2_k127_4037420_0 protein containing a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 602.0
HKD2_k127_4037420_1 AAA domain (dynein-related subfamily) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007388 556.0
HKD2_k127_4037420_10 Subtilase family - - - 0.000000000000003268 89.0
HKD2_k127_4037420_11 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000609 65.0
HKD2_k127_4037420_2 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 359.0
HKD2_k127_4037420_3 Putative heavy-metal chelation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000803 275.0
HKD2_k127_4037420_4 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001047 259.0
HKD2_k127_4037420_5 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000005234 224.0
HKD2_k127_4037420_6 Domain of Unknown Function (DUF349) - - - 0.0000000000000000000000000000000000000000000000000000006231 220.0
HKD2_k127_4037420_7 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000001139 199.0
HKD2_k127_4037420_8 Domain of unknown function (DUF1330) - - - 0.000000000000000000000000000000000000000000001083 167.0
HKD2_k127_4037420_9 Universal stress protein family - - - 0.000000000000000000000000000003321 126.0
HKD2_k127_4056859_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 1.347e-294 930.0
HKD2_k127_4056859_1 transport system, fused permease components - - - 5.2e-283 893.0
HKD2_k127_4056859_10 Aldehyde dehydrogenase family K00154 - 1.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 306.0
HKD2_k127_4056859_11 peptidase S1 and S6, chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000195 271.0
HKD2_k127_4056859_12 Glutathione S-transferase, N-terminal domain K11208 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009962 282.0
HKD2_k127_4056859_13 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000005587 190.0
HKD2_k127_4056859_14 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000005278 169.0
HKD2_k127_4056859_15 - - - - 0.00000000000000000001446 104.0
HKD2_k127_4056859_16 Domain of unknown function (DUF1850) - - - 0.00000000000003498 79.0
HKD2_k127_4056859_2 Domain of unknown function (DUF3482) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 556.0
HKD2_k127_4056859_3 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 527.0
HKD2_k127_4056859_4 fad dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 469.0
HKD2_k127_4056859_5 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 454.0
HKD2_k127_4056859_6 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 452.0
HKD2_k127_4056859_7 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 441.0
HKD2_k127_4056859_8 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 419.0
HKD2_k127_4056859_9 Protein of unknown function (DUF2868) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 402.0
HKD2_k127_4079163_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006951 531.0
HKD2_k127_4079163_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 428.0
HKD2_k127_4079163_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 390.0
HKD2_k127_4079163_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 394.0
HKD2_k127_4079163_4 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 371.0
HKD2_k127_4079163_5 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 331.0
HKD2_k127_4079163_6 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 327.0
HKD2_k127_4079163_7 thioesterase K01075 - 3.1.2.23 0.0000000000000000000000000000000000000003996 164.0
HKD2_k127_4079163_8 Rubrerythrin - - - 0.000000000000000000000000000000001527 138.0
HKD2_k127_4093269_0 Belongs to the glycosyl hydrolase 13 family K02438 - 3.2.1.196 0.0 1352.0
HKD2_k127_4093269_1 ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 1.249e-259 803.0
HKD2_k127_4093269_10 Nitrile hydratase beta subunit - - - 0.00000000000000000000000000000000000000000000000001804 192.0
HKD2_k127_4093269_11 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000003924 98.0
HKD2_k127_4093269_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 7.56e-235 735.0
HKD2_k127_4093269_3 oligoendopeptidase F K08602 - - 1.842e-220 700.0
HKD2_k127_4093269_4 Nucleotidyl transferase K00975 - 2.7.7.27 3.121e-212 667.0
HKD2_k127_4093269_5 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 606.0
HKD2_k127_4093269_6 ABC-type dipeptide transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 497.0
HKD2_k127_4093269_7 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008876 351.0
HKD2_k127_4093269_8 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002112 290.0
HKD2_k127_4093269_9 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001885 253.0
HKD2_k127_4094296_0 His Kinase A (phospho-acceptor) domain - - - 0.0 1150.0
HKD2_k127_4094296_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 9.47e-281 880.0
HKD2_k127_4094296_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 451.0
HKD2_k127_4094296_11 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 386.0
HKD2_k127_4094296_12 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 379.0
HKD2_k127_4094296_13 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 306.0
HKD2_k127_4094296_14 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 297.0
HKD2_k127_4094296_15 Adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000005016 267.0
HKD2_k127_4094296_16 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000005437 231.0
HKD2_k127_4094296_17 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000001397 228.0
HKD2_k127_4094296_18 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000001382 181.0
HKD2_k127_4094296_19 Protein of unknown function, DUF485 - - - 0.0000000000000000000000000000000000000002165 152.0
HKD2_k127_4094296_2 AMP-binding enzyme C-terminal domain K00666 - - 1.764e-258 812.0
HKD2_k127_4094296_20 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000003173 162.0
HKD2_k127_4094296_21 Domain of unknown function DUF123 - - - 0.000000000000000000000000000000007978 130.0
HKD2_k127_4094296_22 NnrU protein - - - 0.000000000000000000000000000002774 130.0
HKD2_k127_4094296_23 - - - - 0.000000000000008132 77.0
HKD2_k127_4094296_24 Protein of unknown function (DUF1499) - - - 0.0000001996 53.0
HKD2_k127_4094296_25 MORN repeat protein - - - 0.000003247 57.0
HKD2_k127_4094296_3 DNA polymerase III K02342 - 2.7.7.7 1.67e-237 754.0
HKD2_k127_4094296_4 tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 1.974e-200 634.0
HKD2_k127_4094296_5 Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 609.0
HKD2_k127_4094296_6 ABC transporter substrate-binding protein K02035,K13889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 614.0
HKD2_k127_4094296_7 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 542.0
HKD2_k127_4094296_8 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 479.0
HKD2_k127_4094296_9 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 458.0
HKD2_k127_4095555_0 Rod shape-determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 594.0
HKD2_k127_4095555_1 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 474.0
HKD2_k127_4095555_2 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009545 264.0
HKD2_k127_4095555_3 shape-determining protein MreD K03571 - - 0.00000000000000000000000000000000000000001323 159.0
HKD2_k127_4134408_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1321.0
HKD2_k127_4134408_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 496.0
HKD2_k127_4134408_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000003052 250.0
HKD2_k127_4134408_3 OmpA family K03286 - - 0.000000000000000000000000000000000000000000000004591 182.0
HKD2_k127_4134408_4 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000001719 143.0
HKD2_k127_4135333_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 3.267e-271 850.0
HKD2_k127_4135333_1 glutaminyl-tRNA K01886 - 6.1.1.18 1.278e-258 811.0
HKD2_k127_4135333_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004681 411.0
HKD2_k127_4135333_11 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 403.0
HKD2_k127_4135333_12 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 398.0
HKD2_k127_4135333_13 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008759 391.0
HKD2_k127_4135333_14 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 381.0
HKD2_k127_4135333_15 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006365 304.0
HKD2_k127_4135333_16 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 303.0
HKD2_k127_4135333_17 major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 301.0
HKD2_k127_4135333_18 Domain of unknown function (DUF4337) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001164 244.0
HKD2_k127_4135333_19 Psort location CytoplasmicMembrane, score 10.00 K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003525 243.0
HKD2_k127_4135333_2 Transmembrane secretion effector - - - 1.747e-246 784.0
HKD2_k127_4135333_20 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000001465 210.0
HKD2_k127_4135333_21 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000007154 205.0
HKD2_k127_4135333_22 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000000003474 190.0
HKD2_k127_4135333_23 SWI complex, BAF60b domains - - - 0.0000000000000000000000000000000000000000001814 162.0
HKD2_k127_4135333_24 Preprotein translocase, YajC subunit K03210 - - 0.0000000000000000000000000000000000004912 144.0
HKD2_k127_4135333_25 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000009202 148.0
HKD2_k127_4135333_26 Protein of unknown function (DUF2442) - - - 0.00000000000000002326 88.0
HKD2_k127_4135333_3 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 3.098e-205 645.0
HKD2_k127_4135333_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 616.0
HKD2_k127_4135333_5 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 580.0
HKD2_k127_4135333_6 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 552.0
HKD2_k127_4135333_7 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 555.0
HKD2_k127_4135333_8 Superfamily I DNA and RNA helicases K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 524.0
HKD2_k127_4135333_9 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 476.0
HKD2_k127_4177047_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1519.0
HKD2_k127_4177047_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 3.341e-223 718.0
HKD2_k127_4177047_10 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 477.0
HKD2_k127_4177047_11 Cys/Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 467.0
HKD2_k127_4177047_12 Binding-protein-dependent transport system inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 458.0
HKD2_k127_4177047_13 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 444.0
HKD2_k127_4177047_14 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 438.0
HKD2_k127_4177047_15 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 412.0
HKD2_k127_4177047_16 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 389.0
HKD2_k127_4177047_17 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 391.0
HKD2_k127_4177047_18 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 350.0
HKD2_k127_4177047_19 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 298.0
HKD2_k127_4177047_2 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 1.883e-215 686.0
HKD2_k127_4177047_20 binding-protein-dependent transport systems inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 310.0
HKD2_k127_4177047_21 MASE2 domain K18968 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005575 293.0
HKD2_k127_4177047_22 Peptidase C26 K01658,K07010 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004114 289.0
HKD2_k127_4177047_23 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002205 291.0
HKD2_k127_4177047_24 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006285 267.0
HKD2_k127_4177047_25 Domain of unknown function (DUF4743) - - - 0.000000000000000000000000000000000000000000000000000000000009543 217.0
HKD2_k127_4177047_26 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000007078 195.0
HKD2_k127_4177047_27 TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - 0.000000000000000000000000000000000000000000000009056 180.0
HKD2_k127_4177047_28 Shikimate kinase K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000000378 179.0
HKD2_k127_4177047_29 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000001468 167.0
HKD2_k127_4177047_3 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 609.0
HKD2_k127_4177047_30 AAA domain - - - 0.000000002467 70.0
HKD2_k127_4177047_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 581.0
HKD2_k127_4177047_5 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 570.0
HKD2_k127_4177047_6 binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 575.0
HKD2_k127_4177047_7 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009317 556.0
HKD2_k127_4177047_8 PFAM extracellular solute-binding protein family 1 K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 521.0
HKD2_k127_4177047_9 TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 502.0
HKD2_k127_4234166_0 Ribonucleotide reductase, barrel domain K00525 - 1.17.4.1 6.675e-201 639.0
HKD2_k127_4234166_1 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.631e-195 625.0
HKD2_k127_4234166_2 Methylmalonyl-CoA mutase K01848 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 604.0
HKD2_k127_4234166_3 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001023 293.0
HKD2_k127_4260944_0 M61 glycyl aminopeptidase - - - 3.117e-215 685.0
HKD2_k127_4260944_1 Sigma-54 interaction domain protein K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 553.0
HKD2_k127_4260944_11 Ami_2 K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 0.00000000000000000000004906 102.0
HKD2_k127_4260944_12 PAS domain - - - 0.000000000000000000001623 99.0
HKD2_k127_4260944_13 - K06950 - - 0.000000001414 65.0
HKD2_k127_4260944_14 - - - - 0.0000000199 61.0
HKD2_k127_4260944_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 549.0
HKD2_k127_4260944_3 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 565.0
HKD2_k127_4260944_4 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000832 410.0
HKD2_k127_4260944_5 ATPase histidine kinase DNA gyrase B HSP90 domain protein K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 355.0
HKD2_k127_4260944_6 phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 308.0
HKD2_k127_4260944_7 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 300.0
HKD2_k127_4260944_8 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004657 288.0
HKD2_k127_4260944_9 maleylacetoacetate isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000002209 222.0
HKD2_k127_426669_0 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 3.927e-298 934.0
HKD2_k127_426669_1 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 534.0
HKD2_k127_426669_10 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000001094 233.0
HKD2_k127_426669_11 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000002178 211.0
HKD2_k127_426669_12 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.00000000000000000000000000000000000000000000001204 178.0
HKD2_k127_426669_13 - - - - 0.0000000000000000000000000000004846 128.0
HKD2_k127_426669_14 Transcriptional regulator K04033 - - 0.000000000000000000000003867 114.0
HKD2_k127_426669_15 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000000000002178 92.0
HKD2_k127_426669_16 Transcriptional regulatory protein, C terminal - - - 0.0002423 53.0
HKD2_k127_426669_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007772 450.0
HKD2_k127_426669_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 378.0
HKD2_k127_426669_4 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 351.0
HKD2_k127_426669_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 341.0
HKD2_k127_426669_6 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009138 315.0
HKD2_k127_426669_7 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 307.0
HKD2_k127_426669_8 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 297.0
HKD2_k127_426669_9 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003822 246.0
HKD2_k127_4283263_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 550.0
HKD2_k127_4283263_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000388 281.0
HKD2_k127_4283263_2 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007805 280.0
HKD2_k127_4283263_3 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000000000000008727 183.0
HKD2_k127_4283263_4 HAD-hyrolase-like - - - 0.0000000000000000000000000000000000000000000008991 176.0
HKD2_k127_4283263_5 Pfam Biopolymer transport protein ExbD TolR K03560 - - 0.000000000000000000000000000000000000000005611 158.0
HKD2_k127_4283263_6 TonB C terminal K03646 - - 0.000000000000000000000000000000000001678 153.0
HKD2_k127_4283263_7 Tol-pal system-associated acyl-CoA thioesterase K07107 - - 0.000000000000000000000000000001677 137.0
HKD2_k127_4285212_0 mandelate racemase muconate lactonizing K01706 - 4.2.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 609.0
HKD2_k127_4285212_1 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 466.0
HKD2_k127_4285212_10 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000001621 84.0
HKD2_k127_4285212_2 PFAM fumarylacetoacetate (FAA) hydrolase K16856 - 4.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004224 409.0
HKD2_k127_4285212_3 Alcohol dehydrogenase GroES-like domain K00098 - 1.1.1.264 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 422.0
HKD2_k127_4285212_4 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 326.0
HKD2_k127_4285212_5 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000003458 268.0
HKD2_k127_4285212_6 Regulatory protein GntR HTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002159 246.0
HKD2_k127_4285212_7 Tripartite ATP-independent periplasmic transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000592 233.0
HKD2_k127_4285212_8 Prolyl oligopeptidase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000302 215.0
HKD2_k127_4285212_9 Transcriptional regulator K07722 - - 0.00000000000000000000000000000000000000000000000000000006583 219.0
HKD2_k127_4298809_0 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008993 604.0
HKD2_k127_4298809_1 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 581.0
HKD2_k127_4298809_2 Alcohol dehydrogenase GroES-like domain K07538 - 1.1.1.368 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 503.0
HKD2_k127_4298809_3 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 312.0
HKD2_k127_4298809_4 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000007589 154.0
HKD2_k127_4313647_0 Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 398.0
HKD2_k127_4313647_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 303.0
HKD2_k127_4313647_2 PFAM HupH hydrogenase expression protein K03618 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002021 248.0
HKD2_k127_4313647_3 Hydrogenase expression formation protein K03605 - - 0.00000000000000000000000000000000000000000000000000000000000000002241 229.0
HKD2_k127_4313647_4 Ni,Fe-hydrogenase I large subunit - - - 0.000000000000000000000000000000000000000000000000000000003963 214.0
HKD2_k127_4313647_5 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000005827 119.0
HKD2_k127_4313647_6 Hydrogenase-1 expression protein HyaE K03619 - - 0.0000000000000000000000000001625 128.0
HKD2_k127_4313647_7 [NiFe]-hydrogenase assembly, chaperone, HybE - - - 0.0000000000000000000000000006485 123.0
HKD2_k127_4313647_8 HupF/HypC family K04653 - - 0.000000000000000000000005449 105.0
HKD2_k127_4313647_9 Rubredoxin - - - 0.00000000000000000000003152 100.0
HKD2_k127_4358676_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 5.79e-215 671.0
HKD2_k127_4358676_1 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 366.0
HKD2_k127_4358676_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 356.0
HKD2_k127_4358676_3 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000001331 217.0
HKD2_k127_4358676_4 Nitroreductase family - - - 0.000000000000000000000000000000000000000000005102 171.0
HKD2_k127_455117_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 550.0
HKD2_k127_455117_1 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 504.0
HKD2_k127_455117_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 350.0
HKD2_k127_455117_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000008362 199.0
HKD2_k127_455117_4 haloacid dehalogenase-like hydrolase - - - 0.0000000000001188 80.0
HKD2_k127_4633735_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 7.721e-319 985.0
HKD2_k127_4633735_1 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 1.966e-297 923.0
HKD2_k127_5110304_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 1.674e-300 945.0
HKD2_k127_5110304_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005821 298.0
HKD2_k127_5110304_2 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000007128 186.0
HKD2_k127_5110304_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000004823 155.0
HKD2_k127_5110304_4 - - - - 0.00000000000000000000000000305 128.0
HKD2_k127_5110304_5 hydrolase K01091 - 3.1.3.18 0.0000000000000001377 90.0
HKD2_k127_5110304_6 - - - - 0.00005484 55.0
HKD2_k127_5115013_0 TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - 1.728e-270 844.0
HKD2_k127_5115013_1 NMT1-like family K07080 - - 0.000000000000002751 75.0
HKD2_k127_5127946_0 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 420.0
HKD2_k127_5127946_1 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 342.0
HKD2_k127_5127946_2 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.000000000000000000004304 108.0
HKD2_k127_5137921_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1735.0
HKD2_k127_5137921_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 4.839e-268 838.0
HKD2_k127_5137921_10 ADP-ribosylglycohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 360.0
HKD2_k127_5137921_11 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001769 278.0
HKD2_k127_5137921_12 TIGRFAM TIGR00268 family protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001328 275.0
HKD2_k127_5137921_13 Class II Aldolase and Adducin N-terminal domain K22130 - 4.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000009115 263.0
HKD2_k127_5137921_14 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001432 225.0
HKD2_k127_5137921_15 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000008108 238.0
HKD2_k127_5137921_16 Cupin 2, conserved barrel domain protein K00450,K00971,K09988,K11312 - 1.13.11.4,2.7.7.13,5.3.1.15 0.00000000000000000000000000000000000000000000000006276 197.0
HKD2_k127_5137921_17 TIGRFAM yecA family protein K07039 - - 0.00000000000000000000000000000000008747 145.0
HKD2_k127_5137921_18 - - - - 0.00000000000000000000000000000008672 129.0
HKD2_k127_5137921_19 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000001336 100.0
HKD2_k127_5137921_2 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 594.0
HKD2_k127_5137921_20 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000001436 77.0
HKD2_k127_5137921_3 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 528.0
HKD2_k127_5137921_4 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 520.0
HKD2_k127_5137921_5 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 506.0
HKD2_k127_5137921_6 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 427.0
HKD2_k127_5137921_7 OHCU decarboxylase K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 392.0
HKD2_k127_5137921_8 Ribulose bisphosphate carboxylase large chain, catalytic domain K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 376.0
HKD2_k127_5137921_9 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008444 357.0
HKD2_k127_5141953_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1677.0
HKD2_k127_5141953_1 AcrB/AcrD/AcrF family K07787 - - 0.0 1515.0
HKD2_k127_5141953_10 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 464.0
HKD2_k127_5141953_11 NADPH quinone K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 433.0
HKD2_k127_5141953_12 Bacterial periplasmic substrate-binding proteins K10001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007873 454.0
HKD2_k127_5141953_13 ABC-type polar amino acid transport system, ATPase component K10004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 422.0
HKD2_k127_5141953_14 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 405.0
HKD2_k127_5141953_15 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 384.0
HKD2_k127_5141953_16 PFAM PfkB domain protein K00874 - 2.7.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 342.0
HKD2_k127_5141953_17 Binding-protein-dependent transport system inner membrane component K02029,K10003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 316.0
HKD2_k127_5141953_18 Binding-protein-dependent transport system inner membrane component K10002 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 314.0
HKD2_k127_5141953_19 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 311.0
HKD2_k127_5141953_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 2.05e-296 923.0
HKD2_k127_5141953_20 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 298.0
HKD2_k127_5141953_21 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000231 281.0
HKD2_k127_5141953_22 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008367 276.0
HKD2_k127_5141953_23 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001186 258.0
HKD2_k127_5141953_24 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002503 286.0
HKD2_k127_5141953_25 Aldolase K01631 - 4.1.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000005797 246.0
HKD2_k127_5141953_26 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001312 246.0
HKD2_k127_5141953_27 PFAM 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.00000000000000000000000000000000000000000000000000000000000000000002003 244.0
HKD2_k127_5141953_28 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000000000000004637 233.0
HKD2_k127_5141953_29 Phenylacetic acid degradation protein PaaY K02617,K08279 - - 0.00000000000000000000000000000000000000000000000000000000000000001057 231.0
HKD2_k127_5141953_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.066e-259 814.0
HKD2_k127_5141953_30 peptidase inhibitor activity K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000000000000000001592 239.0
HKD2_k127_5141953_31 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000001679 210.0
HKD2_k127_5141953_32 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000008682 192.0
HKD2_k127_5141953_33 4Fe-4S dicluster domain K00196,K05796 - - 0.0000000000000000000000000000000000000000000000000116 195.0
HKD2_k127_5141953_34 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000001184 171.0
HKD2_k127_5141953_35 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.0000000000000000000000000000000000000001141 169.0
HKD2_k127_5141953_36 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000004272 152.0
HKD2_k127_5141953_37 - - - - 0.00000000000000000000000000000000003081 152.0
HKD2_k127_5141953_38 Copper resistance protein D - - - 0.00000000000000000000000000000004039 130.0
HKD2_k127_5141953_39 Uncharacterized ACR, COG1993 - - - 0.000000000000000000000000000000275 132.0
HKD2_k127_5141953_4 OPT oligopeptide transporter protein - - - 3.044e-248 797.0
HKD2_k127_5141953_40 SnoaL-like domain - - - 0.000000000000000000000002171 106.0
HKD2_k127_5141953_41 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000009766 86.0
HKD2_k127_5141953_42 Subtilase family - - - 0.0000000000000004413 93.0
HKD2_k127_5141953_45 OmpA family - - - 0.0000004302 60.0
HKD2_k127_5141953_47 MoaE protein K21142 - 2.8.1.12 0.0004005 46.0
HKD2_k127_5141953_5 Transport of potassium into the cell K03549 - - 6.375e-231 730.0
HKD2_k127_5141953_6 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 624.0
HKD2_k127_5141953_7 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides K00364 - 1.7.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003981 520.0
HKD2_k127_5141953_8 PFAM polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 481.0
HKD2_k127_5141953_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 499.0
HKD2_k127_5191276_0 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 316.0
HKD2_k127_5191276_1 Sigma E regulatory protein, MucB RseB K03598 - - 0.000000000000000000000000000000000000000000000000000000000000000007444 241.0
HKD2_k127_5191276_2 L-asparaginase II - - - 0.00000000000000000000000005606 109.0
HKD2_k127_5191276_3 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.00000000000002849 84.0
HKD2_k127_5237804_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 4.213e-202 644.0
HKD2_k127_5237804_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 406.0
HKD2_k127_5237804_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004517 243.0
HKD2_k127_5237804_3 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000647 211.0
HKD2_k127_5243306_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 9.806e-195 628.0
HKD2_k127_5243306_1 Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00122 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 409.0
HKD2_k127_5285671_0 5-oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 0.0 1716.0
HKD2_k127_5285671_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 1.344e-225 716.0
HKD2_k127_5285671_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 423.0
HKD2_k127_5285671_11 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007492 399.0
HKD2_k127_5285671_12 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 399.0
HKD2_k127_5285671_13 Arginine N-succinyltransferase beta subunit K00673 - 2.3.1.109 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 392.0
HKD2_k127_5285671_14 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 359.0
HKD2_k127_5285671_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006757 359.0
HKD2_k127_5285671_16 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 341.0
HKD2_k127_5285671_17 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 334.0
HKD2_k127_5285671_18 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007484 291.0
HKD2_k127_5285671_19 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004436 256.0
HKD2_k127_5285671_2 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 2.118e-217 680.0
HKD2_k127_5285671_20 Glutathione peroxidase K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000005236 246.0
HKD2_k127_5285671_21 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008678 266.0
HKD2_k127_5285671_22 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005748 244.0
HKD2_k127_5285671_23 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000004057 211.0
HKD2_k127_5285671_24 Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.000000000000000000000000000000000000000000000000000000004784 204.0
HKD2_k127_5285671_25 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000567 185.0
HKD2_k127_5285671_26 Acetyltransferase - - - 0.000000000000000000000000000000000000000000000001323 189.0
HKD2_k127_5285671_27 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000006917 187.0
HKD2_k127_5285671_28 PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding K00567 - 2.1.1.63 0.0000000000000000000000000000000000000007401 168.0
HKD2_k127_5285671_29 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000004163 137.0
HKD2_k127_5285671_3 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) K01484 - 3.5.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 524.0
HKD2_k127_5285671_30 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000001617 131.0
HKD2_k127_5285671_31 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.00000000000000000000000000000144 126.0
HKD2_k127_5285671_32 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000001194 128.0
HKD2_k127_5285671_4 ABC-type dipeptide transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 537.0
HKD2_k127_5285671_5 aminotransferase K00821,K00840 GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.11,2.6.1.17,2.6.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 518.0
HKD2_k127_5285671_6 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 521.0
HKD2_k127_5285671_7 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009194 517.0
HKD2_k127_5285671_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 446.0
HKD2_k127_5285671_9 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 441.0
HKD2_k127_5289186_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.0 1393.0
HKD2_k127_5289186_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 9.055e-280 866.0
HKD2_k127_5289186_10 Acetyltransferase (GNAT) domain K02348 - - 0.00000000000000000000000000000000000000009107 156.0
HKD2_k127_5289186_11 Glycosyltransferase like family - - - 0.0000000000000000000000000000000000000001408 174.0
HKD2_k127_5289186_12 EVE domain - - - 0.00000000000000000000000000000003331 131.0
HKD2_k127_5289186_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 3.972e-251 782.0
HKD2_k127_5289186_3 Subtilase family - - - 5.21e-207 694.0
HKD2_k127_5289186_4 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009221 619.0
HKD2_k127_5289186_5 III protein, CoA-transferase family K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 550.0
HKD2_k127_5289186_6 Tartrate dehydrogenase K07246 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363 1.1.1.83,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 542.0
HKD2_k127_5289186_7 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 522.0
HKD2_k127_5289186_8 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 351.0
HKD2_k127_5289186_9 Protein of unknown function (DUF1631) - - - 0.000000000000000000000000000000000000000000000000002352 200.0
HKD2_k127_5393542_0 4-hydroxyphenylacetate K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 4.029e-209 687.0
HKD2_k127_5393542_1 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 613.0
HKD2_k127_5393542_2 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 495.0
HKD2_k127_5393542_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000000008599 186.0
HKD2_k127_5393542_4 phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000215 143.0
HKD2_k127_5393542_5 Isochorismatase hydrolase - - - 0.0000000000000000000000000000000001783 146.0
HKD2_k127_5393542_6 - - - - 0.00000000000000000000008864 112.0
HKD2_k127_5393542_7 Thioredoxin K03672 - 1.8.1.8 0.00000000129 59.0
HKD2_k127_5393872_0 Heat shock 70 kDa protein K04043 - - 0.0 1034.0
HKD2_k127_5393872_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 571.0
HKD2_k127_5393872_10 Molybdopterin-guanine dinucleotide biosynthesis protein MobA K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000002102 187.0
HKD2_k127_5393872_11 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 0.00000000000000000000001163 103.0
HKD2_k127_5393872_12 epimerase K00091 - 1.1.1.219 0.0000000000000000000001291 114.0
HKD2_k127_5393872_13 Copper binding periplasmic protein CusF - - - 0.0000000000000008251 91.0
HKD2_k127_5393872_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 498.0
HKD2_k127_5393872_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 488.0
HKD2_k127_5393872_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 435.0
HKD2_k127_5393872_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 414.0
HKD2_k127_5393872_6 Two component regulator three Y domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 404.0
HKD2_k127_5393872_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 295.0
HKD2_k127_5393872_8 Belongs to the peptidase S11 family K07262 GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016043,GO:0016787,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0030203,GO:0032505,GO:0042221,GO:0042493,GO:0042597,GO:0043093,GO:0043170,GO:0044238,GO:0044464,GO:0045229,GO:0050896,GO:0051301,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000386 281.0
HKD2_k127_5393872_9 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000000003595 182.0
HKD2_k127_5401626_0 enoyl-CoA hydratase K15513 - 4.1.2.44 4.656e-262 820.0
HKD2_k127_5401626_1 type II secretion system protein E K02454,K02504,K02652,K12276 - - 8.825e-260 813.0
HKD2_k127_5401626_10 Domain of unknown function DUF21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 452.0
HKD2_k127_5401626_11 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 350.0
HKD2_k127_5401626_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K15546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 344.0
HKD2_k127_5401626_13 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008245 305.0
HKD2_k127_5401626_14 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 298.0
HKD2_k127_5401626_15 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000007439 261.0
HKD2_k127_5401626_16 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000833 260.0
HKD2_k127_5401626_17 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000458 235.0
HKD2_k127_5401626_18 Domain of unknown function (DUF4863) - - - 0.000000000000000000000000000000000000000000000000000000034 200.0
HKD2_k127_5401626_19 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000000002089 207.0
HKD2_k127_5401626_2 benzoyl-CoA oxygenase K15512 - 1.14.13.208 3.716e-255 796.0
HKD2_k127_5401626_20 PFAM Cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000002397 204.0
HKD2_k127_5401626_21 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.00000000000000000000000000000000000000000000000000005152 193.0
HKD2_k127_5401626_22 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000005636 197.0
HKD2_k127_5401626_23 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000008462 153.0
HKD2_k127_5401626_24 LppC putative lipoprotein K07121 - - 0.0000000000000000000000000000000000000924 159.0
HKD2_k127_5401626_25 PFAM transport-associated - - - 0.000000000000000000000000000000000000434 150.0
HKD2_k127_5401626_26 Domain of unknown function (DUF5122) beta-propeller - - - 0.00000000000000000000000000000000003813 158.0
HKD2_k127_5401626_27 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000000005068 126.0
HKD2_k127_5401626_28 Extracellular nuclease - - - 0.000000000000000000000000000002926 142.0
HKD2_k127_5401626_29 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000008395 112.0
HKD2_k127_5401626_3 AAA ATPase domain - - - 1.338e-243 798.0
HKD2_k127_5401626_30 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000003145 117.0
HKD2_k127_5401626_31 RDD family - - - 0.000000000001562 81.0
HKD2_k127_5401626_32 Alginate lyase - - - 0.000001483 64.0
HKD2_k127_5401626_33 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.00006203 56.0
HKD2_k127_5401626_4 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 2.452e-242 759.0
HKD2_k127_5401626_5 membrane K13277,K15125,K15539 - - 2.003e-219 763.0
HKD2_k127_5401626_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 9.032e-210 660.0
HKD2_k127_5401626_7 Oxidoreductase NAD-binding domain K15511 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 609.0
HKD2_k127_5401626_8 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 567.0
HKD2_k127_5401626_9 type II secretion system protein K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 514.0
HKD2_k127_551926_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 370.0
HKD2_k127_551926_1 Nitrate reductase delta subunit - - - 0.000000000000000000000000000000001681 147.0
HKD2_k127_551926_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.000000000000000000000001171 108.0
HKD2_k127_5584073_0 Molecular chaperone. Has ATPase activity K04079 - - 1.01e-263 828.0
HKD2_k127_5584073_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 403.0
HKD2_k127_5584073_10 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000001765 162.0
HKD2_k127_5584073_11 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000003555 146.0
HKD2_k127_5584073_12 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000004004 138.0
HKD2_k127_5584073_13 Cytochrome c, class I - - - 0.00000000000000000000005287 106.0
HKD2_k127_5584073_2 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 363.0
HKD2_k127_5584073_3 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 308.0
HKD2_k127_5584073_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004214 293.0
HKD2_k127_5584073_5 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000003579 240.0
HKD2_k127_5584073_6 Part of a membrane complex involved in electron transport K03616 - - 0.0000000000000000000000000000000000000000000000000000000000027 220.0
HKD2_k127_5584073_7 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000001042 201.0
HKD2_k127_5584073_8 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000003214 194.0
HKD2_k127_5584073_9 Domain of unknown function (DUF1841) - - - 0.000000000000000000000000000000000000000000006425 179.0
HKD2_k127_5584665_0 Binding-protein-dependent transport system inner membrane component K02011 - - 6.242e-264 832.0
HKD2_k127_5584665_1 COG1960 Acyl-CoA dehydrogenases K20035 - - 8.353e-247 775.0
HKD2_k127_5584665_10 Bacterial extracellular solute-binding protein K02012,K11081 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 374.0
HKD2_k127_5584665_11 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 305.0
HKD2_k127_5584665_12 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003373 250.0
HKD2_k127_5584665_13 SMART metal-dependent phosphohydrolase, HD region K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000000000000000006862 222.0
HKD2_k127_5584665_14 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000001551 210.0
HKD2_k127_5584665_15 - - - - 0.00000000000000000000000000000000000000000000000000001174 211.0
HKD2_k127_5584665_16 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000001336 195.0
HKD2_k127_5584665_17 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000000000005356 171.0
HKD2_k127_5584665_18 Psort location Cytoplasmic, score 8.96 K07039 - - 0.00000000000000000000000000000007239 135.0
HKD2_k127_5584665_19 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000003349 131.0
HKD2_k127_5584665_2 abc transporter K15738 - - 1.226e-205 673.0
HKD2_k127_5584665_20 Serine aminopeptidase, S33 - - - 0.0006148 46.0
HKD2_k127_5584665_3 TrkA-N domain - - - 1.466e-195 627.0
HKD2_k127_5584665_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 481.0
HKD2_k127_5584665_5 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 463.0
HKD2_k127_5584665_6 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 419.0
HKD2_k127_5584665_7 PFAM ROK family protein K00845,K00847 - 2.7.1.2,2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 421.0
HKD2_k127_5584665_8 electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 404.0
HKD2_k127_5584665_9 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 381.0
HKD2_k127_5635759_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1462.0
HKD2_k127_5635759_1 Amidohydrolase family - - - 2.917e-259 814.0
HKD2_k127_5635759_10 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000005159 187.0
HKD2_k127_5635759_11 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000004603 127.0
HKD2_k127_5635759_2 PFAM peptidase S10 serine carboxypeptidase - - - 2.019e-210 667.0
HKD2_k127_5635759_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 502.0
HKD2_k127_5635759_4 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 457.0
HKD2_k127_5635759_5 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 438.0
HKD2_k127_5635759_6 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 299.0
HKD2_k127_5635759_7 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002885 262.0
HKD2_k127_5635759_8 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000008367 183.0
HKD2_k127_5635759_9 Belongs to the DnaA family K10763 - - 0.000000000000000000000000000000000000000000000007693 181.0
HKD2_k127_5636943_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1309.0
HKD2_k127_5636943_1 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000000000000000005066 227.0
HKD2_k127_570445_0 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 531.0
HKD2_k127_570445_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 516.0
HKD2_k127_570445_10 alpha-L-arabinofuranosidase - - - 0.000000000002336 79.0
HKD2_k127_570445_11 Belongs to the peptidase S8 family K14645 - - 0.000009787 59.0
HKD2_k127_570445_2 ATPase family associated with various cellular activities (AAA) K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 441.0
HKD2_k127_570445_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 378.0
HKD2_k127_570445_4 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 383.0
HKD2_k127_570445_5 Transposase K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 338.0
HKD2_k127_570445_6 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002548 245.0
HKD2_k127_570445_7 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001304 246.0
HKD2_k127_570445_8 cellulose binding - - - 0.0000000000000000000000000000000000000000000001823 184.0
HKD2_k127_570445_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000002395 158.0
HKD2_k127_5799677_0 Cytochrome c-type biogenesis protein CcmF K02198 - - 6.014e-242 754.0
HKD2_k127_5799677_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 363.0
HKD2_k127_5799677_2 malic enzyme K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 320.0
HKD2_k127_5799677_3 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001024 253.0
HKD2_k127_5799677_4 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000000000001397 207.0
HKD2_k127_5799677_5 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000002274 178.0
HKD2_k127_5806905_0 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0 1283.0
HKD2_k127_5806905_1 FAD linked oxidases, C-terminal domain - - - 0.0 1252.0
HKD2_k127_5806905_10 Methyl-accepting chemotaxis protein K02660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 596.0
HKD2_k127_5806905_11 dihydroorotase K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 578.0
HKD2_k127_5806905_12 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 537.0
HKD2_k127_5806905_13 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 516.0
HKD2_k127_5806905_14 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 456.0
HKD2_k127_5806905_15 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 419.0
HKD2_k127_5806905_16 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 364.0
HKD2_k127_5806905_17 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 349.0
HKD2_k127_5806905_18 COG3540 Phosphodiesterase alkaline phosphatase D K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 353.0
HKD2_k127_5806905_19 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 342.0
HKD2_k127_5806905_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1157.0
HKD2_k127_5806905_20 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 325.0
HKD2_k127_5806905_21 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 319.0
HKD2_k127_5806905_22 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 317.0
HKD2_k127_5806905_23 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 315.0
HKD2_k127_5806905_24 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 305.0
HKD2_k127_5806905_25 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001443 270.0
HKD2_k127_5806905_26 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002038 269.0
HKD2_k127_5806905_27 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000002653 278.0
HKD2_k127_5806905_28 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001238 251.0
HKD2_k127_5806905_29 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000003471 247.0
HKD2_k127_5806905_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1062.0
HKD2_k127_5806905_30 cheY-homologous receiver domain K02657 - - 0.000000000000000000000000000000000000000000000000000000000000005227 222.0
HKD2_k127_5806905_31 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000003238 221.0
HKD2_k127_5806905_32 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000000000007278 199.0
HKD2_k127_5806905_33 phosphohistidine phosphatase K08296 - - 0.0000000000000000000000000000000000000000000000000000009562 198.0
HKD2_k127_5806905_34 RESPONSE REGULATOR receiver K02658 - - 0.0000000000000000000000000000000000000000000000000003213 188.0
HKD2_k127_5806905_35 Pyrimidine operon attenuation protein uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000008478 185.0
HKD2_k127_5806905_36 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000000006691 165.0
HKD2_k127_5806905_37 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000005306 156.0
HKD2_k127_5806905_38 Predicted integral membrane protein (DUF2269) - - - 0.00000000000000000000000000000000000000009052 160.0
HKD2_k127_5806905_39 - - - - 0.0000000000000000000000000000000000000009867 159.0
HKD2_k127_5806905_4 Elongation factor G, domain IV K02355 - - 3.943e-299 932.0
HKD2_k127_5806905_40 Chemotaxis signal transduction protein K02659 - - 0.000000000000000000000000000000000000005442 157.0
HKD2_k127_5806905_41 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000001811 145.0
HKD2_k127_5806905_42 Hsp20/alpha crystallin family - - - 0.00000000000000000000000000005852 122.0
HKD2_k127_5806905_43 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000002728 108.0
HKD2_k127_5806905_44 - - - - 0.00000000000000000000000069 121.0
HKD2_k127_5806905_45 Protein of unknown function (DUF2782) - - - 0.00000000000000004017 85.0
HKD2_k127_5806905_5 Helicase K03657 - 3.6.4.12 4.78e-294 923.0
HKD2_k127_5806905_6 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.557e-275 863.0
HKD2_k127_5806905_7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.568e-252 784.0
HKD2_k127_5806905_8 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 4.111e-238 745.0
HKD2_k127_5806905_9 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 597.0
HKD2_k127_58152_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1549.0
HKD2_k127_58152_1 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 482.0
HKD2_k127_58152_2 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 456.0
HKD2_k127_58152_3 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006945 269.0
HKD2_k127_58152_4 Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
HKD2_k127_58152_5 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000002598 203.0
HKD2_k127_5928526_0 Belongs to the IlvD Edd family - - - 7.793e-277 861.0
HKD2_k127_5928526_1 (ABC) transporter K01995 - - 6.792e-211 685.0
HKD2_k127_5928526_10 Belongs to the HpcH HpaI aldolase family K01630 - 4.1.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 321.0
HKD2_k127_5928526_11 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 320.0
HKD2_k127_5928526_12 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 329.0
HKD2_k127_5928526_13 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 306.0
HKD2_k127_5928526_14 Enoyl-(Acyl carrier protein) reductase K22185 - 1.1.1.175 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005688 276.0
HKD2_k127_5928526_15 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001559 261.0
HKD2_k127_5928526_16 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000008716 241.0
HKD2_k127_5928526_17 NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000000000000000006196 224.0
HKD2_k127_5928526_18 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000001448 176.0
HKD2_k127_5928526_19 YGGT family - - - 0.00000000000000000000000000000000000009268 148.0
HKD2_k127_5928526_2 Belongs to the glycosyl hydrolase 31 family K01811 GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0016787,GO:0016798,GO:0042802,GO:0080176 3.2.1.177 9.813e-207 671.0
HKD2_k127_5928526_20 DUF167 K09131 - - 0.00000000000000000000000002813 119.0
HKD2_k127_5928526_21 twitching motility protein K02669 - - 0.0000000000000000000005577 94.0
HKD2_k127_5928526_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 557.0
HKD2_k127_5928526_4 ABC-type sugar transport system periplasmic component K10236 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 537.0
HKD2_k127_5928526_5 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 488.0
HKD2_k127_5928526_6 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 441.0
HKD2_k127_5928526_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 409.0
HKD2_k127_5928526_8 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 365.0
HKD2_k127_5928526_9 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 338.0
HKD2_k127_5976535_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 581.0
HKD2_k127_5976535_1 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 539.0
HKD2_k127_5976535_2 taurine ABC transporter, periplasmic binding protein K15551 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009454 426.0
HKD2_k127_620799_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008762 582.0
HKD2_k127_620799_1 oxidoreductase K13020 - 1.1.1.335 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 430.0
HKD2_k127_620799_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 387.0
HKD2_k127_620799_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 394.0
HKD2_k127_620799_4 PFAM MaoC domain protein dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002483 254.0
HKD2_k127_620799_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000003589 243.0
HKD2_k127_620799_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000004047 223.0
HKD2_k127_620799_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000001293 176.0
HKD2_k127_620799_8 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.000001669 53.0
HKD2_k127_6389845_0 Psort location Cytoplasmic, score 8.96 K07462 - - 3.942e-205 670.0
HKD2_k127_6389845_1 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 484.0
HKD2_k127_6389845_2 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 360.0
HKD2_k127_6389845_3 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 310.0
HKD2_k127_6389845_4 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661,K07536 - 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000007868 209.0
HKD2_k127_6389845_5 Protein conserved in bacteria - - - 0.0000000000000000000000000002716 128.0
HKD2_k127_6390559_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 0.0 1673.0
HKD2_k127_6390559_1 Peptidase M16 inactive domain protein K07263 - - 1.397e-270 860.0
HKD2_k127_6390559_10 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 421.0
HKD2_k127_6390559_11 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 431.0
HKD2_k127_6390559_12 Extracellular solute-binding protein family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 412.0
HKD2_k127_6390559_13 KduI/IolB family K03337 - 5.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 393.0
HKD2_k127_6390559_14 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 376.0
HKD2_k127_6390559_15 PFAM ABC transporter related K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 373.0
HKD2_k127_6390559_16 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 361.0
HKD2_k127_6390559_17 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 359.0
HKD2_k127_6390559_18 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009201 342.0
HKD2_k127_6390559_19 Helix-turn-helix domain, rpiR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 327.0
HKD2_k127_6390559_2 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 8.236e-268 841.0
HKD2_k127_6390559_20 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K03336 - 3.7.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 311.0
HKD2_k127_6390559_21 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 312.0
HKD2_k127_6390559_22 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 302.0
HKD2_k127_6390559_23 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 288.0
HKD2_k127_6390559_24 inositol mono-phosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000483 169.0
HKD2_k127_6390559_25 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000001277 149.0
HKD2_k127_6390559_26 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000182 147.0
HKD2_k127_6390559_28 PFAM CHRD domain containing protein - - - 0.0000000000000000000000000003345 134.0
HKD2_k127_6390559_29 amino acid-binding ACT domain protein K04767 - - 0.000000000000000000000000002618 116.0
HKD2_k127_6390559_3 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.994e-248 786.0
HKD2_k127_6390559_30 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000006229 113.0
HKD2_k127_6390559_31 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000002181 77.0
HKD2_k127_6390559_32 FeoA - - - 0.000001312 62.0
HKD2_k127_6390559_4 Sulfatase - - - 1.288e-213 688.0
HKD2_k127_6390559_5 Metallopeptidase family M24 - - - 1.215e-208 659.0
HKD2_k127_6390559_6 Extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 562.0
HKD2_k127_6390559_7 Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 500.0
HKD2_k127_6390559_8 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 489.0
HKD2_k127_6390559_9 Xylose isomerase K03335 - 4.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 448.0
HKD2_k127_6398607_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 470.0
HKD2_k127_6398607_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 426.0
HKD2_k127_6398607_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 435.0
HKD2_k127_6398607_3 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 400.0
HKD2_k127_6398607_4 Family of unknown function (DUF5329) - - - 0.00000000000000000000000000000000001573 138.0
HKD2_k127_64184_0 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007015 440.0
HKD2_k127_64184_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000078 377.0
HKD2_k127_64184_2 negative regulation of DNA-templated transcription, initiation K02616 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010124,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010817,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043170,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098754,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002834 266.0
HKD2_k127_6426177_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K01086,K03841 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 552.0
HKD2_k127_6426177_1 Phosphoribulokinase K00855 - 2.7.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 477.0
HKD2_k127_6426177_2 CbbX protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 454.0
HKD2_k127_6446326_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 3.046e-208 659.0
HKD2_k127_6446326_1 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 604.0
HKD2_k127_6446326_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K04108 - 1.2.5.3,1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 547.0
HKD2_k127_6446326_3 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 381.0
HKD2_k127_6446326_4 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 380.0
HKD2_k127_6446326_5 CO dehydrogenase flavoprotein C-terminal domain K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 324.0
HKD2_k127_6446326_6 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001339 247.0
HKD2_k127_6446326_7 ferredoxin - - - 0.0000000000000000000000000000000000005578 144.0
HKD2_k127_6446326_8 Hemerythrin HHE cation binding domain - - - 0.000000000001899 77.0
HKD2_k127_6465756_0 histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 360.0
HKD2_k127_6465756_1 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004404 280.0
HKD2_k127_6465756_2 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000007407 231.0
HKD2_k127_6481344_0 AcrB/AcrD/AcrF family - - - 0.0 1305.0
HKD2_k127_6481344_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1263.0
HKD2_k127_6481344_10 4 iron, 4 sulfur cluster binding K04014,K08353,K08358,K16293 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 306.0
HKD2_k127_6481344_11 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 310.0
HKD2_k127_6481344_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007563 285.0
HKD2_k127_6481344_13 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006562 276.0
HKD2_k127_6481344_14 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K04107 - 1.2.5.3,1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000001541 246.0
HKD2_k127_6481344_15 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.000000000000000000000000000000000000000000000000000000000000003037 224.0
HKD2_k127_6481344_16 Permease of the major facilitator superfamily K08369 - - 0.0000000000000000000000000000000000000000000000000000004972 214.0
HKD2_k127_6481344_17 DMSO reductase anchor subunit (DmsC) K18363 - - 0.000000000000000000000000000000000000000000000000002129 202.0
HKD2_k127_6481344_18 PFAM Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000004541 178.0
HKD2_k127_6481344_19 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000002184 169.0
HKD2_k127_6481344_2 molybdopterin cofactor binding K08352 - 1.8.5.5 1.506e-316 985.0
HKD2_k127_6481344_20 Thioesterase - - - 0.0000000000000000000000000000000000000000004531 166.0
HKD2_k127_6481344_21 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000008977 163.0
HKD2_k127_6481344_22 - K07112 - - 0.00000000000000000000000000000000000000002529 162.0
HKD2_k127_6481344_23 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K07112 - - 0.000000000000000000000000000000000000002981 161.0
HKD2_k127_6481344_24 transcriptional regulator - - - 0.00000000000000000000000000000000000001008 153.0
HKD2_k127_6481344_25 Cobalt uptake substrate-specific transmembrane region - - - 0.0000000000000000000000000000542 128.0
HKD2_k127_6481344_26 Protein of unknown function (DUF2892) - - - 0.000000000000000000002824 104.0
HKD2_k127_6481344_27 Invasion gene expression up-regulator, SirB - - - 0.00000000000000000003963 97.0
HKD2_k127_6481344_28 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K04107 - 1.2.5.3,1.3.7.9 0.0000000000000001943 79.0
HKD2_k127_6481344_29 Protein of unknown function (DUF2892) - - - 0.00000000000003382 85.0
HKD2_k127_6481344_3 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 2.381e-225 703.0
HKD2_k127_6481344_4 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 604.0
HKD2_k127_6481344_5 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 583.0
HKD2_k127_6481344_6 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 458.0
HKD2_k127_6481344_7 thiosulfate sulfurtransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 426.0
HKD2_k127_6481344_8 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 356.0
HKD2_k127_6481344_9 4Fe-4S binding domain K18362 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009954 360.0
HKD2_k127_6482293_0 2-aminobenzoate-CoA ligase K08295 - 6.2.1.32 1.889e-239 751.0
HKD2_k127_6482293_1 PFAM Acyl-CoA dehydrogenase K00252 - 1.3.8.6 3.558e-210 659.0
HKD2_k127_6482293_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 364.0
HKD2_k127_6482293_3 Maleylacetoacetate isomerase K01801 - 5.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000009069 279.0
HKD2_k127_6482293_4 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000002204 200.0
HKD2_k127_6482293_5 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-17-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000004066 169.0
HKD2_k127_649526_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 616.0
HKD2_k127_649526_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 404.0
HKD2_k127_649526_2 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 345.0
HKD2_k127_649526_3 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 285.0
HKD2_k127_649526_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000004503 171.0
HKD2_k127_649526_5 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000000002472 167.0
HKD2_k127_6503350_0 Sulfate transporter antisigma-factor antagonist STAS - - - 3.151e-213 678.0
HKD2_k127_6503350_1 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 5.57e-205 659.0
HKD2_k127_6503350_10 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000006869 191.0
HKD2_k127_6503350_11 Thiamine-binding protein - - - 0.000000000000000000000000000000000000000000003853 169.0
HKD2_k127_6503350_12 transposase IS116 IS110 IS902 family protein K07486 - - 0.0000000000000000000000000000000000000003581 154.0
HKD2_k127_6503350_13 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.000000000000000000007952 100.0
HKD2_k127_6503350_14 transposase IS116 IS110 IS902 family protein K07486 - - 0.00003576 52.0
HKD2_k127_6503350_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 520.0
HKD2_k127_6503350_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 466.0
HKD2_k127_6503350_4 protein conserved in bacteria K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 477.0
HKD2_k127_6503350_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 422.0
HKD2_k127_6503350_6 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 352.0
HKD2_k127_6503350_7 surface antigen K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 356.0
HKD2_k127_6503350_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009281 247.0
HKD2_k127_6503350_9 - - - - 0.000000000000000000000000000000000000000000000000000000000003026 226.0
HKD2_k127_6511814_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.108e-297 926.0
HKD2_k127_6511814_1 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 1.974e-264 826.0
HKD2_k127_6511814_10 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 319.0
HKD2_k127_6511814_11 Response regulator receiver domain protein K07684 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002733 261.0
HKD2_k127_6511814_12 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000001233 226.0
HKD2_k127_6511814_13 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000004841 216.0
HKD2_k127_6511814_14 Protein conserved in bacteria K04750 - - 0.0000000000000000000000000000000000000000000000000000005806 197.0
HKD2_k127_6511814_15 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.0000000000000000000001001 111.0
HKD2_k127_6511814_16 PFAM DGPFAETKE family protein - - - 0.00000000000000000009419 89.0
HKD2_k127_6511814_18 amine dehydrogenase activity - - - 0.0000000001443 76.0
HKD2_k127_6511814_19 Domain of unknown function (DUF4118) - - - 0.000000002334 69.0
HKD2_k127_6511814_2 nitrite transporter K02575 - - 6.439e-231 719.0
HKD2_k127_6511814_3 Major Facilitator Superfamily K02575 - - 2.076e-215 675.0
HKD2_k127_6511814_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 9.016e-208 666.0
HKD2_k127_6511814_5 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.922e-200 667.0
HKD2_k127_6511814_6 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 1.152e-198 632.0
HKD2_k127_6511814_7 Type IV pili methyl-accepting chemotaxis transducer N-term K07673 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000842 546.0
HKD2_k127_6511814_8 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 511.0
HKD2_k127_6511814_9 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 458.0
HKD2_k127_6556855_0 arylsulfatase A K01130 - 3.1.6.1 1.959e-260 814.0
HKD2_k127_6556855_1 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 2.71e-232 728.0
HKD2_k127_6556855_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 323.0
HKD2_k127_6556855_3 response regulator - - - 0.0000000000000000000000000000000000000000000004791 176.0
HKD2_k127_6556855_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000001165 164.0
HKD2_k127_6556855_5 Bacterial transcriptional activator domain - - - 0.0000000000000005432 91.0
HKD2_k127_6568387_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 3.064e-218 718.0
HKD2_k127_6568387_1 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 538.0
HKD2_k127_6568387_10 D,D-heptose 1,7-bisphosphate phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003924 280.0
HKD2_k127_6568387_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001112 259.0
HKD2_k127_6568387_12 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000001694 254.0
HKD2_k127_6568387_13 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000005498 230.0
HKD2_k127_6568387_15 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000003013 183.0
HKD2_k127_6568387_16 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000001759 176.0
HKD2_k127_6568387_17 Chalcone isomerase-like - - - 0.00000000000000000000000000000000002056 142.0
HKD2_k127_6568387_18 Tetratricopeptide repeat - - - 0.00000000000000000000000000000157 124.0
HKD2_k127_6568387_19 Frataxin-like domain - - - 0.0000000000000000000000001692 109.0
HKD2_k127_6568387_2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 521.0
HKD2_k127_6568387_20 - - - - 0.00000000000000007829 94.0
HKD2_k127_6568387_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 448.0
HKD2_k127_6568387_4 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 439.0
HKD2_k127_6568387_5 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 425.0
HKD2_k127_6568387_6 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 424.0
HKD2_k127_6568387_7 Transporter associated domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 386.0
HKD2_k127_6568387_8 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 312.0
HKD2_k127_6568387_9 AAA domain K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 297.0
HKD2_k127_6615862_0 Tricorn protease homolog K08676 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 505.0
HKD2_k127_6615862_1 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.00001574 49.0
HKD2_k127_6618740_0 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 9.982e-285 887.0
HKD2_k127_6618740_1 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 2.083e-207 664.0
HKD2_k127_6618740_10 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 291.0
HKD2_k127_6618740_11 response regulator K08083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 297.0
HKD2_k127_6618740_12 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004909 242.0
HKD2_k127_6618740_13 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000001717 222.0
HKD2_k127_6618740_14 Required for insertion of 4Fe-4S clusters K15724 - - 0.000000000000000000000000000000000000000000000000000000000001814 211.0
HKD2_k127_6618740_15 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000004394 194.0
HKD2_k127_6618740_16 redox protein, regulator of disulfide bond formation K07397 - - 0.000000000000000000000000000000000000000000000001462 178.0
HKD2_k127_6618740_17 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000008905 185.0
HKD2_k127_6618740_18 Thioredoxin-like - - - 0.00000000000000000000000000000000000000001205 160.0
HKD2_k127_6618740_19 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000005607 154.0
HKD2_k127_6618740_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 578.0
HKD2_k127_6618740_20 - - - - 0.0000000000000000000000009975 120.0
HKD2_k127_6618740_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004073 492.0
HKD2_k127_6618740_4 NADP oxidoreductase coenzyme F420-dependent K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 419.0
HKD2_k127_6618740_5 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 383.0
HKD2_k127_6618740_6 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 377.0
HKD2_k127_6618740_7 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 332.0
HKD2_k127_6618740_8 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 333.0
HKD2_k127_6618740_9 TRAP transporter solute receptor TAXI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 329.0
HKD2_k127_6698684_0 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 402.0
HKD2_k127_6698684_1 Transcriptional regulator, LysR family K21703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 366.0
HKD2_k127_6698684_2 Phosphotransferase system, mannose fructose-specific component IIA K02821 - 2.7.1.194 0.000000000000000000000000000000000000000000002093 168.0
HKD2_k127_6698684_3 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000003704 134.0
HKD2_k127_6698684_4 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 0.0000000000000000000001206 98.0
HKD2_k127_6698684_5 phosphocarrier, HPr family K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000005757 86.0
HKD2_k127_6714948_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007794 481.0
HKD2_k127_6714948_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 386.0
HKD2_k127_675939_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1064.0
HKD2_k127_675939_1 Histidine kinase-like ATPases - - - 8.301e-199 629.0
HKD2_k127_675939_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 430.0
HKD2_k127_675939_3 Histidine kinase K20976 - - 0.0000000000000002545 83.0
HKD2_k127_675939_5 - - - - 0.0004214 50.0
HKD2_k127_6762289_0 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 330.0
HKD2_k127_6762289_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000003602 205.0
HKD2_k127_6762289_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000003535 170.0
HKD2_k127_6807153_0 Protein of unknown function (DUF3141) - - - 0.0 1048.0
HKD2_k127_6807153_1 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 1.399e-230 733.0
HKD2_k127_6807153_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000002482 231.0
HKD2_k127_6807153_11 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000449 200.0
HKD2_k127_6807153_12 membrane - - - 0.0000000000000000000000000000000000000000000000372 194.0
HKD2_k127_6807153_13 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K09181,K15520 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 0.0000000000000000000000000000000000000000000003939 173.0
HKD2_k127_6807153_14 Protein of unknown function (DUF3302) - - - 0.00000000000000000000000000000000000000001267 162.0
HKD2_k127_6807153_15 - - - - 0.0000000000000000000000000000000000000003074 166.0
HKD2_k127_6807153_16 - - - - 0.00000000000000000000000000000000000383 144.0
HKD2_k127_6807153_17 Na( )-dependent transporter - - - 0.000000000000000000000004375 112.0
HKD2_k127_6807153_18 - - - - 0.00000000000000000000003446 104.0
HKD2_k127_6807153_19 PFAM Rieske 2Fe-2S domain protein K00363,K05710 - 1.7.1.15 0.0000001441 60.0
HKD2_k127_6807153_2 phosphate K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 502.0
HKD2_k127_6807153_20 general secretion pathway protein - - - 0.000007611 51.0
HKD2_k127_6807153_21 - - - - 0.0002511 49.0
HKD2_k127_6807153_3 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 431.0
HKD2_k127_6807153_4 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 448.0
HKD2_k127_6807153_5 COG0524 Sugar kinases, ribokinase family K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 420.0
HKD2_k127_6807153_6 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 439.0
HKD2_k127_6807153_7 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 313.0
HKD2_k127_6807153_8 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 306.0
HKD2_k127_6807153_9 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004477 263.0
HKD2_k127_6834949_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 572.0
HKD2_k127_6834949_1 ABC transporter substrate-binding protein PnrA-like K02058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 501.0
HKD2_k127_6834949_10 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000001945 109.0
HKD2_k127_6834949_11 - - - - 0.00000000000000000000000003525 120.0
HKD2_k127_6834949_12 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000008955 111.0
HKD2_k127_6834949_13 - - - - 0.00000000000000000004529 102.0
HKD2_k127_6834949_14 - - - - 0.0000000000000000001413 95.0
HKD2_k127_6834949_2 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 377.0
HKD2_k127_6834949_3 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000003297 231.0
HKD2_k127_6834949_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000001478 224.0
HKD2_k127_6834949_5 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000003397 196.0
HKD2_k127_6834949_6 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000006299 197.0
HKD2_k127_6834949_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000001506 184.0
HKD2_k127_6834949_8 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000371 144.0
HKD2_k127_6834949_9 COG3278 Cbb3-type cytochrome oxidase, subunit 1 - - - 0.000000000000000000000000000000008912 135.0
HKD2_k127_6857286_0 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.98e-220 694.0
HKD2_k127_6857286_1 PrpF protein K16514 - 5.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 524.0
HKD2_k127_6857286_2 PFAM Amidohydrolase 2 K10221 - 3.1.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 516.0
HKD2_k127_6857286_3 PFAM Short-chain dehydrogenase reductase SDR K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 378.0
HKD2_k127_6857286_4 LysR substrate binding domain K19338 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 297.0
HKD2_k127_6857286_5 Pfam:Methyltransf_6 K10218 - 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001945 313.0
HKD2_k127_6857286_6 ABC transporter substrate-binding protein K02035,K13889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009372 268.0
HKD2_k127_6857286_7 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000003932 231.0
HKD2_k127_6864830_0 GTPase activity K06207 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0042802,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045901,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:2000112 - 1.189e-252 796.0
HKD2_k127_6864830_1 Belongs to the DEAD box helicase family K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 516.0
HKD2_k127_6864830_2 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 376.0
HKD2_k127_6864830_3 PFAM Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 368.0
HKD2_k127_6864830_4 Subtilase family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 359.0
HKD2_k127_6864830_5 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 316.0
HKD2_k127_6864830_6 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000008177 235.0
HKD2_k127_6864830_7 Belongs to the ABC transporter superfamily K02031,K02032,K13892,K13896 - - 0.000000000000761 73.0
HKD2_k127_6956383_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1050.0
HKD2_k127_6956383_1 NADH-quinone oxidoreductase K00336 - 1.6.5.3 7.967e-314 981.0
HKD2_k127_6956383_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 509.0
HKD2_k127_6956383_11 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 468.0
HKD2_k127_6956383_12 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 390.0
HKD2_k127_6956383_13 HD domain K13815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 376.0
HKD2_k127_6956383_14 Proton-conducting membrane transporter K00342,K05561,K05568 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006062 374.0
HKD2_k127_6956383_15 Cysteine-rich domain K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 355.0
HKD2_k127_6956383_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 319.0
HKD2_k127_6956383_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 291.0
HKD2_k127_6956383_18 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 289.0
HKD2_k127_6956383_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006069 284.0
HKD2_k127_6956383_2 Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05559 - - 1.423e-287 910.0
HKD2_k127_6956383_20 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005549 258.0
HKD2_k127_6956383_21 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000005677 231.0
HKD2_k127_6956383_22 LUD domain K00782 - - 0.0000000000000000000000000000000000000000000000000000000000000000481 232.0
HKD2_k127_6956383_23 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000009618 230.0
HKD2_k127_6956383_24 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000000000000000002972 198.0
HKD2_k127_6956383_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000006399 198.0
HKD2_k127_6956383_26 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000000000000000000000141 169.0
HKD2_k127_6956383_27 PFAM regulatory protein, MerR - - - 0.0000000000000000000000000000000000000000000004953 169.0
HKD2_k127_6956383_28 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000007804 171.0
HKD2_k127_6956383_29 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000000007821 161.0
HKD2_k127_6956383_3 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 9.23e-285 889.0
HKD2_k127_6956383_30 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000001013 161.0
HKD2_k127_6956383_31 Na+/H+ ion antiporter subunit - - - 0.000000000000000000000000000000000002953 158.0
HKD2_k127_6956383_32 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000000001098 119.0
HKD2_k127_6956383_33 NADH-ubiquinone oxidoreductase subunit 4L K05560 - - 0.000000000000000000000000002409 128.0
HKD2_k127_6956383_34 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000007054 107.0
HKD2_k127_6956383_35 Tripartite tricarboxylate transporter TctA family - - - 0.00000000000000000000001592 101.0
HKD2_k127_6956383_36 PFAM Na H antiporter subunit K05564 - - 0.000000000000000000001404 104.0
HKD2_k127_6956383_37 Multiple resistance and pH regulation protein F K05563 - - 0.000000000000000000007085 99.0
HKD2_k127_6956383_38 Bacterial protein of unknown function (DUF883) - - - 0.0000000007614 65.0
HKD2_k127_6956383_39 Universal stress protein family - - - 0.00003044 55.0
HKD2_k127_6956383_4 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 5.133e-250 796.0
HKD2_k127_6956383_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 7.67e-244 759.0
HKD2_k127_6956383_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.934e-230 729.0
HKD2_k127_6956383_7 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 8.538e-221 694.0
HKD2_k127_6956383_8 4Fe-4S ferredoxin, iron-sulfur binding K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 610.0
HKD2_k127_6956383_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 539.0
HKD2_k127_700445_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 574.0
HKD2_k127_700445_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 368.0
HKD2_k127_7051756_0 Poly-beta-hydroxybutyrate polymerase K03821 - - 2.998e-267 839.0
HKD2_k127_7051756_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 5.337e-253 791.0
HKD2_k127_7051756_10 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000009951 246.0
HKD2_k127_7051756_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000000000002504 212.0
HKD2_k127_7051756_12 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.0000000000000000000000000000000000000000000000000000004542 202.0
HKD2_k127_7051756_13 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000325 153.0
HKD2_k127_7051756_14 Pathogenicity locus - - - 0.00000000000000000000002674 115.0
HKD2_k127_7051756_15 coenzyme F420 binding K07226 - - 0.000000000000000000005622 101.0
HKD2_k127_7051756_16 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.00000001304 59.0
HKD2_k127_7051756_2 Phosphoesterase family - - - 7.535e-197 642.0
HKD2_k127_7051756_3 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 526.0
HKD2_k127_7051756_4 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007899 501.0
HKD2_k127_7051756_5 alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 439.0
HKD2_k127_7051756_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 415.0
HKD2_k127_7051756_7 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009983 376.0
HKD2_k127_7051756_8 DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 313.0
HKD2_k127_7051756_9 Damage-inducible protein DinB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002666 263.0
HKD2_k127_7056874_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 488.0
HKD2_k127_7056874_1 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 310.0
HKD2_k127_7056874_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008358 296.0
HKD2_k127_7056874_3 Predicted integral membrane protein (DUF2189) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002644 263.0
HKD2_k127_7056874_4 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007504 260.0
HKD2_k127_7056874_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000002552 199.0
HKD2_k127_7056874_6 Universal stress protein family - - - 0.000000000000000000000000000000002232 137.0
HKD2_k127_7056874_7 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000000000000000000001104 126.0
HKD2_k127_707749_0 PfkB domain protein K03338 - 2.7.1.92 7.588e-296 925.0
HKD2_k127_707749_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K03336 - 3.7.1.22 1.909e-199 655.0
HKD2_k127_707749_2 EamA-like transporter family K15268 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005189 268.0
HKD2_k127_707749_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000003169 211.0
HKD2_k127_7162144_0 2Fe-2S iron-sulfur cluster binding domain K00523 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 534.0
HKD2_k127_7162144_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 372.0
HKD2_k127_7162144_2 Sulfurtransferase TusA - - - 0.000000000000000000000000000000000000000000000000000000001587 204.0
HKD2_k127_7162144_3 - - - - 0.0000000000000000000000000000000000000000000000001047 186.0
HKD2_k127_7162144_4 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000006179 161.0
HKD2_k127_7162144_5 Cas6 Crispr - - - 0.00000000000000000000000000000000002379 145.0
HKD2_k127_7162144_6 - - - - 0.00000005923 55.0
HKD2_k127_7319367_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K18138 - - 0.0 1615.0
HKD2_k127_7319367_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 9.23e-297 955.0
HKD2_k127_7319367_10 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003638 267.0
HKD2_k127_7319367_11 ABC-type amino acid transport signal transduction systems periplasmic component domain K10001 GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000004706 226.0
HKD2_k127_7319367_12 ABC-type amino acid transport signal transduction systems periplasmic component domain K10001 GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000002855 224.0
HKD2_k127_7319367_13 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000001142 186.0
HKD2_k127_7319367_14 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000003632 89.0
HKD2_k127_7319367_15 Glycine zipper 2TM domain - - - 0.00000001443 63.0
HKD2_k127_7319367_16 - - - - 0.000006472 55.0
HKD2_k127_7319367_2 transport systems, ATPase components K02056 - 3.6.3.17 6.724e-211 674.0
HKD2_k127_7319367_3 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 568.0
HKD2_k127_7319367_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 529.0
HKD2_k127_7319367_5 Xanthine dehydrogenase small subunit K13481 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 511.0
HKD2_k127_7319367_6 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 479.0
HKD2_k127_7319367_7 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 366.0
HKD2_k127_7319367_8 PFAM ABC transporter related K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 307.0
HKD2_k127_7319367_9 Mammalian cell entry related domain protein K02067,K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000142 266.0
HKD2_k127_748851_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1261.0
HKD2_k127_748851_1 Belongs to the ABC transporter superfamily K02031,K02032,K13892 - - 3.908e-283 879.0
HKD2_k127_748851_10 Permease, YjgP YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 340.0
HKD2_k127_748851_11 Permease YjgP YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 295.0
HKD2_k127_748851_12 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002118 292.0
HKD2_k127_748851_13 Protein of unknown function (DUF1071) - - - 0.0000000000000000000000000000000000000000000000000000001862 200.0
HKD2_k127_748851_14 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000000000000000009306 168.0
HKD2_k127_748851_15 dna polymerase III (Chi subunit) K02339 - 2.7.7.7 0.00000000000000000000000000000000000007517 146.0
HKD2_k127_748851_16 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000007997 134.0
HKD2_k127_748851_18 Domain of unknown function (DUF1738) - - - 0.00000000000000001076 83.0
HKD2_k127_748851_19 YqaJ-like viral recombinase domain - - - 0.0001588 54.0
HKD2_k127_748851_2 ABC-type dipeptide transport system, periplasmic K02035,K13889 - - 1.771e-243 761.0
HKD2_k127_748851_20 - - - - 0.000539 43.0
HKD2_k127_748851_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 1.671e-209 662.0
HKD2_k127_748851_4 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K13890 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 498.0
HKD2_k127_748851_5 phospho-2-dehydro-3-deoxyheptonate aldolase K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 496.0
HKD2_k127_748851_6 PFAM binding-protein-dependent transport systems inner membrane component K13891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 481.0
HKD2_k127_748851_7 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 415.0
HKD2_k127_748851_8 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 384.0
HKD2_k127_748851_9 Major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 378.0
HKD2_k127_7669075_0 Transposase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 525.0
HKD2_k127_7669075_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 383.0
HKD2_k127_7669075_2 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 368.0
HKD2_k127_7675882_0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 467.0
HKD2_k127_7675882_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000001738 233.0
HKD2_k127_7692416_0 Cytochrome B561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000000000000001518 239.0
HKD2_k127_7692416_1 DoxX family K15977 - - 0.00000000000000000000000000000000000000000002883 166.0
HKD2_k127_7692416_2 Subtilase family - - - 0.000000000000000002225 100.0
HKD2_k127_7692416_3 Ricin-type beta-trefoil - - - 0.000005838 59.0
HKD2_k127_7699762_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1069.0
HKD2_k127_7699762_1 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 2.318e-212 678.0
HKD2_k127_7699762_10 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 385.0
HKD2_k127_7699762_11 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 385.0
HKD2_k127_7699762_12 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 373.0
HKD2_k127_7699762_13 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 378.0
HKD2_k127_7699762_14 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 369.0
HKD2_k127_7699762_15 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 356.0
HKD2_k127_7699762_16 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 351.0
HKD2_k127_7699762_17 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 332.0
HKD2_k127_7699762_18 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 319.0
HKD2_k127_7699762_19 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 327.0
HKD2_k127_7699762_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00895,K21071 - 2.7.1.11,2.7.1.90 1.772e-203 640.0
HKD2_k127_7699762_20 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004628 321.0
HKD2_k127_7699762_21 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 308.0
HKD2_k127_7699762_22 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 289.0
HKD2_k127_7699762_23 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 287.0
HKD2_k127_7699762_24 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001408 276.0
HKD2_k127_7699762_25 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005084 273.0
HKD2_k127_7699762_26 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000001431 273.0
HKD2_k127_7699762_27 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000001359 249.0
HKD2_k127_7699762_28 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000002086 229.0
HKD2_k127_7699762_29 MlaC protein K07323 - - 0.00000000000000000000000000000000000000000000000000000000005216 222.0
HKD2_k127_7699762_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 573.0
HKD2_k127_7699762_30 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000006926 197.0
HKD2_k127_7699762_31 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.000000000000000000000000000000000000000000000000001733 187.0
HKD2_k127_7699762_32 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000003531 197.0
HKD2_k127_7699762_33 Peptidase S16, lon domain protein K07157 - - 0.0000000000000000000000000000000000000000002152 177.0
HKD2_k127_7699762_34 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000000144 169.0
HKD2_k127_7699762_35 Biopolymer transport protein K03559 - - 0.0000000000000000000000000000000000000002563 156.0
HKD2_k127_7699762_36 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000000000004711 151.0
HKD2_k127_7699762_37 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.000000000000000000000000000000000209 139.0
HKD2_k127_7699762_38 ribosomal subunit interface protein K05808 - - 0.000000000000000000000000000000001055 150.0
HKD2_k127_7699762_39 Belongs to the BolA IbaG family - - - 0.00000000000000000000000005101 121.0
HKD2_k127_7699762_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 576.0
HKD2_k127_7699762_40 Belongs to the UPF0434 family K09791 - - 0.0000000000000000000000001594 106.0
HKD2_k127_7699762_41 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000005576 85.0
HKD2_k127_7699762_42 STAS domain K07122 - - 0.00001085 57.0
HKD2_k127_7699762_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 546.0
HKD2_k127_7699762_6 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 416.0
HKD2_k127_7699762_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 404.0
HKD2_k127_7699762_8 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 407.0
HKD2_k127_7699762_9 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 399.0
HKD2_k127_7714575_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.202e-224 703.0
HKD2_k127_7714575_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009124 505.0
HKD2_k127_7748897_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1234.0
HKD2_k127_7748897_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1114.0
HKD2_k127_7748897_10 TIR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 359.0
HKD2_k127_7748897_11 PFAM isochorismatase hydrolase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 312.0
HKD2_k127_7748897_12 Phage lysozyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 331.0
HKD2_k127_7748897_13 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 325.0
HKD2_k127_7748897_14 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000195 238.0
HKD2_k127_7748897_15 - - - - 0.00000000000000000000000000000000000000000000000000000000002774 216.0
HKD2_k127_7748897_16 Thioesterase superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000372 197.0
HKD2_k127_7748897_17 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000001705 175.0
HKD2_k127_7748897_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000001398 168.0
HKD2_k127_7748897_19 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000001266 147.0
HKD2_k127_7748897_2 Competence protein ComEC Rec2 K02238 - - 9.378e-206 668.0
HKD2_k127_7748897_20 - - - - 0.000000000000000000006591 100.0
HKD2_k127_7748897_21 RecX family - - - 0.00000000000000000001137 107.0
HKD2_k127_7748897_22 - - - - 0.000000000001043 74.0
HKD2_k127_7748897_23 FR47-like protein - - - 0.00000006915 55.0
HKD2_k127_7748897_3 ABC transporter substrate-binding protein K02035,K13889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 589.0
HKD2_k127_7748897_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 568.0
HKD2_k127_7748897_5 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 477.0
HKD2_k127_7748897_6 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 422.0
HKD2_k127_7748897_7 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 423.0
HKD2_k127_7748897_8 Protein of unknown function (DUF3422) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 381.0
HKD2_k127_7748897_9 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 361.0
HKD2_k127_7768468_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1011.0
HKD2_k127_7768468_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 1.785e-292 910.0
HKD2_k127_7768468_10 dna polymerase iii K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000008285 222.0
HKD2_k127_7768468_11 Type II secretion system protein K K02460 - - 0.0000000000000000000000000000000000000000000000000000001203 211.0
HKD2_k127_7768468_12 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000006168 195.0
HKD2_k127_7768468_13 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000001471 178.0
HKD2_k127_7768468_14 NLP P60 protein - - - 0.0000000000000000000000000000000000000000000001494 175.0
HKD2_k127_7768468_15 PFAM Type IV pilus assembly PilZ K02676 - - 0.0000000000000000000000000000000000000000002858 161.0
HKD2_k127_7768468_16 Ankyrin repeat K06867 - - 0.00000000000000000000000000000000000001484 154.0
HKD2_k127_7768468_17 Type II secretion system (T2SS), protein J K02459 - - 0.000000000000000000001416 106.0
HKD2_k127_7768468_18 General secretion pathway protein I K02458 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000000000000000001366 103.0
HKD2_k127_7768468_19 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000003694 73.0
HKD2_k127_7768468_2 AMP-binding enzyme C-terminal domain K00666 - - 1.066e-226 719.0
HKD2_k127_7768468_20 general secretion pathway protein K02456,K02457,K02458,K02650 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000003393 61.0
HKD2_k127_7768468_21 General secretion pathway K02461 - - 0.000005293 59.0
HKD2_k127_7768468_3 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 445.0
HKD2_k127_7768468_4 Alkaline and neutral invertase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 439.0
HKD2_k127_7768468_5 TIGRFAM hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008632 360.0
HKD2_k127_7768468_6 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 354.0
HKD2_k127_7768468_7 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000003144 256.0
HKD2_k127_7768468_8 SmpB protein K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000002592 226.0
HKD2_k127_7768468_9 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000008909 226.0
HKD2_k127_7773840_0 Belongs to the IlvD Edd family K01690 - 4.2.1.12 5.417e-280 870.0
HKD2_k127_7773840_1 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 9.565e-247 773.0
HKD2_k127_7773840_2 TRAP C4-dicarboxylate transport system permease DctM subunit K11690 - - 5.037e-220 691.0
HKD2_k127_7773840_3 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 518.0
HKD2_k127_7773840_4 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000326 226.0
HKD2_k127_7773840_5 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.000007389 48.0
HKD2_k127_7775216_0 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 1.579e-249 774.0
HKD2_k127_7775216_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 492.0
HKD2_k127_7775216_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 463.0
HKD2_k127_7775216_3 PFAM thiamineS protein - - - 0.0000000000000000000000000001218 116.0
HKD2_k127_7776153_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 2.752e-198 625.0
HKD2_k127_7776153_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 2.008e-197 626.0
HKD2_k127_7776153_10 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.00000000002029 73.0
HKD2_k127_7776153_2 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 443.0
HKD2_k127_7776153_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 428.0
HKD2_k127_7776153_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 382.0
HKD2_k127_7776153_5 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 342.0
HKD2_k127_7776153_6 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000781 201.0
HKD2_k127_7776153_7 Maf-like protein K06287 - - 0.000000000000000000000000000000000000633 144.0
HKD2_k127_7776153_8 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000001138 141.0
HKD2_k127_7776153_9 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000001307 112.0
HKD2_k127_7866027_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 483.0
HKD2_k127_7866027_1 ATPase (AAA K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 380.0
HKD2_k127_7866027_2 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 325.0
HKD2_k127_7866027_3 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000007847 170.0
HKD2_k127_7866027_4 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000000451 92.0
HKD2_k127_7894980_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1349.0
HKD2_k127_7894980_1 Protein of unknown function, DUF255 - - - 4.777e-238 755.0
HKD2_k127_7894980_10 - - - - 0.0000000000000000000000000000000000000000000000000000000003276 226.0
HKD2_k127_7894980_11 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000001626 185.0
HKD2_k127_7894980_12 - - - - 0.0000000000000000000000000000000000000000000000007205 182.0
HKD2_k127_7894980_13 Conserved protein of DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000002536 179.0
HKD2_k127_7894980_14 Belongs to the UPF0250 family K09158 - - 0.00000000000000000000000000002065 120.0
HKD2_k127_7894980_15 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000007611 130.0
HKD2_k127_7894980_16 Cytochrome c K08738 - - 0.000000000000000000000000002846 117.0
HKD2_k127_7894980_17 - - - - 0.00000000000000000000004635 116.0
HKD2_k127_7894980_2 The glycine cleavage system catalyzes the degradation of glycine K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 507.0
HKD2_k127_7894980_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 498.0
HKD2_k127_7894980_4 D-amino acid K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 480.0
HKD2_k127_7894980_5 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 440.0
HKD2_k127_7894980_6 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 445.0
HKD2_k127_7894980_7 Aminotransferase class IV K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 375.0
HKD2_k127_7894980_8 response regulator receiver K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009876 286.0
HKD2_k127_7894980_9 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000001448 257.0
HKD2_k127_792693_0 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007434 604.0
HKD2_k127_792693_1 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 370.0
HKD2_k127_792693_2 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000004332 159.0
HKD2_k127_7933183_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.992e-215 674.0
HKD2_k127_7933183_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 456.0
HKD2_k127_7933183_2 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 452.0
HKD2_k127_7933183_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 344.0
HKD2_k127_7933183_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.000000000000000000000000000000000000000005089 155.0
HKD2_k127_7933183_5 Colicin V production K03558 - - 0.0000000000000000000000000003843 121.0
HKD2_k127_7933183_6 PFAM Sporulation domain protein K03749 - - 0.00000000000000009546 91.0
HKD2_k127_8051975_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009945 319.0
HKD2_k127_8051975_1 A domain family that is part of the cupin metalloenzyme superfamily. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 316.0
HKD2_k127_8051975_2 Psort location Cytoplasmic, score K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000003482 192.0
HKD2_k127_8116120_0 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002881 287.0
HKD2_k127_8116120_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000184 214.0
HKD2_k127_8116120_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001099 154.0
HKD2_k127_8116120_3 cytidine deaminase activity K01489 - 3.5.4.5 0.00000000000000000000000000000000001096 141.0
HKD2_k127_8116120_4 TPM domain - - - 0.00000000000000000000000000000002358 134.0
HKD2_k127_8116120_5 TPM domain K06872 - - 0.0000000000000007847 88.0
HKD2_k127_8116120_6 PFAM Sporulation domain protein - - - 0.000000000000002513 84.0
HKD2_k127_8154478_0 Sec-independent protein translocase protein (TatC) K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 318.0
HKD2_k127_8154478_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000001801 184.0
HKD2_k127_8154478_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.00000000000000000000000000000000000000000003162 175.0
HKD2_k127_8154478_3 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000000000001093 135.0
HKD2_k127_8154478_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000000001527 117.0
HKD2_k127_8154478_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000000006944 106.0
HKD2_k127_8154478_6 - - - - 0.000000000000002134 87.0
HKD2_k127_81898_0 Beta/gamma crystallins - - - 0.000000000000000000000000000000000000001012 156.0
HKD2_k127_81898_1 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000002008 157.0
HKD2_k127_8358669_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1030.0
HKD2_k127_8358669_1 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 470.0
HKD2_k127_8358669_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 323.0
HKD2_k127_8358669_3 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000008801 199.0
HKD2_k127_8358669_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000149 177.0
HKD2_k127_8358669_5 - - - - 0.00000000000000000000000000000000000000222 165.0
HKD2_k127_8358669_6 PFAM cobalamin (vitamin B12) biosynthesis CbiX protein K03795 - 4.99.1.3 0.00000000000000000000000764 107.0
HKD2_k127_8358669_7 Predicted membrane protein (DUF2069) - - - 0.0000000001448 74.0
HKD2_k127_8426635_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 4.657e-243 764.0
HKD2_k127_8426635_1 Ammonium Transporter Family K03320,K06580 - - 7.195e-218 681.0
HKD2_k127_8426635_2 homoserine dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 548.0
HKD2_k127_8426635_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 480.0
HKD2_k127_8426635_4 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002228 242.0
HKD2_k127_8426635_5 converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000006557 233.0
HKD2_k127_8426635_6 Tripartite tricarboxylate transporter TctB family - - - 0.000003509 59.0
HKD2_k127_8429873_0 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 365.0
HKD2_k127_8429873_1 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 321.0
HKD2_k127_8429873_2 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000001468 180.0
HKD2_k127_8429873_3 universal stress protein - - - 0.0000000000000000000000000000000001276 140.0
HKD2_k127_8429873_4 Cytochrome c - - - 0.00000000000000000001424 103.0
HKD2_k127_8463545_0 GcpE protein K03526 - 1.17.7.1,1.17.7.3 1.477e-198 628.0
HKD2_k127_8463545_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 597.0
HKD2_k127_8463545_10 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000004591 223.0
HKD2_k127_8463545_11 type 4 pilus biogenesis protein K02656 - - 0.00000000000000000000000000000000000000000000000000002832 199.0
HKD2_k127_8463545_12 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000006569 156.0
HKD2_k127_8463545_13 Domain of unknown function (DUF4115) K15539 - - 0.0000000000000000000000000000000000003526 159.0
HKD2_k127_8463545_14 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000007483 144.0
HKD2_k127_8463545_15 protein conserved in bacteria K09937 - - 0.0000000000000003635 79.0
HKD2_k127_8463545_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 545.0
HKD2_k127_8463545_3 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 537.0
HKD2_k127_8463545_4 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 501.0
HKD2_k127_8463545_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 433.0
HKD2_k127_8463545_6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 357.0
HKD2_k127_8463545_7 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 349.0
HKD2_k127_8463545_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 344.0
HKD2_k127_8463545_9 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000000001681 222.0
HKD2_k127_8528251_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 2.101e-312 967.0
HKD2_k127_8528251_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 5.287e-235 744.0
HKD2_k127_8528251_10 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001499 252.0
HKD2_k127_8528251_11 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000004773 203.0
HKD2_k127_8528251_12 EamA-like transporter family - - - 0.00000000000000000000000000005071 118.0
HKD2_k127_8528251_13 Protein of unknown function (DUF3106) - - - 0.000000000000000000000000001895 124.0
HKD2_k127_8528251_14 membrane protein domain - - - 0.000000000000000005691 91.0
HKD2_k127_8528251_15 Protein of unknown function (DUF3619) - - - 0.00000000004752 74.0
HKD2_k127_8528251_2 Malate synthase K01638 - 2.3.3.9 7.114e-233 734.0
HKD2_k127_8528251_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 582.0
HKD2_k127_8528251_4 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007968 394.0
HKD2_k127_8528251_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 329.0
HKD2_k127_8528251_6 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 298.0
HKD2_k127_8528251_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 294.0
HKD2_k127_8528251_8 Molybdenum ABC transporter periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 291.0
HKD2_k127_8528251_9 TIGRFAM Acetolactate synthase, small subunit K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008483 268.0
HKD2_k127_8943865_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008459 426.0
HKD2_k127_8943865_1 helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008743 278.0
HKD2_k127_8943865_2 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000000000000001173 137.0
HKD2_k127_8943865_3 Protein of unknown function (DUF1059) - - - 0.0000000000000000000000007167 105.0
HKD2_k127_8947178_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1286.0
HKD2_k127_8947178_1 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 3.885e-240 758.0
HKD2_k127_8947178_2 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 449.0
HKD2_k127_8947178_3 Belongs to the peptidase S1C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 426.0
HKD2_k127_8947178_4 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000001203 124.0
HKD2_k127_8947178_5 Phosphopantetheine attachment site - - - 0.00000000000000000000001696 104.0
HKD2_k127_8947178_6 Met-10+ like-protein - - - 0.000000002803 59.0
HKD2_k127_8970538_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.0 1568.0
HKD2_k127_8970538_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1263.0
HKD2_k127_8970538_10 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane K07791,K07792 - - 1.127e-242 754.0
HKD2_k127_8970538_11 Malonate decarboxylase, alpha subunit, transporter K01026 - 2.8.3.1 2.797e-223 699.0
HKD2_k127_8970538_12 Transporter, DASS family K11106,K14445 - - 6.622e-223 706.0
HKD2_k127_8970538_13 Belongs to the thiolase family K00626 - 2.3.1.9 4.549e-216 680.0
HKD2_k127_8970538_14 GMC oxidoreductase - - - 7.009e-207 662.0
HKD2_k127_8970538_15 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway K00351 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 577.0
HKD2_k127_8970538_16 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 564.0
HKD2_k127_8970538_17 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 559.0
HKD2_k127_8970538_18 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 501.0
HKD2_k127_8970538_19 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 496.0
HKD2_k127_8970538_2 Phosphate acetyl butaryl transferase K00029 - 1.1.1.40 0.0 1132.0
HKD2_k127_8970538_20 Sodium:sulfate symporter transmembrane region K11106,K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 490.0
HKD2_k127_8970538_21 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 488.0
HKD2_k127_8970538_22 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 473.0
HKD2_k127_8970538_23 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 455.0
HKD2_k127_8970538_24 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 453.0
HKD2_k127_8970538_25 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 426.0
HKD2_k127_8970538_26 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 445.0
HKD2_k127_8970538_27 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 406.0
HKD2_k127_8970538_28 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 407.0
HKD2_k127_8970538_29 TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 384.0
HKD2_k127_8970538_3 AcyL-CoA dehydrogenase K06445 - - 0.0 1080.0
HKD2_k127_8970538_30 Cyclopropane fatty acid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 383.0
HKD2_k127_8970538_31 dihydroorotate dehydrogenase activity K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 374.0
HKD2_k127_8970538_32 Converts GTP to 7,8-dihydroneopterin triphosphate K01495,K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 343.0
HKD2_k127_8970538_33 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 357.0
HKD2_k127_8970538_34 fumarate reductase respiratory complex transmembrane subunit K00246 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 314.0
HKD2_k127_8970538_35 B12 binding domain K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009297 301.0
HKD2_k127_8970538_36 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 289.0
HKD2_k127_8970538_37 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004642 278.0
HKD2_k127_8970538_38 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009398 290.0
HKD2_k127_8970538_39 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001103 283.0
HKD2_k127_8970538_4 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239,K00244 - 1.3.5.1,1.3.5.4 0.0 1049.0
HKD2_k127_8970538_40 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001617 302.0
HKD2_k127_8970538_41 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000002965 276.0
HKD2_k127_8970538_42 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001848 269.0
HKD2_k127_8970538_43 Bacterial periplasmic substrate-binding proteins K10001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004792 254.0
HKD2_k127_8970538_44 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000001721 237.0
HKD2_k127_8970538_45 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000004115 231.0
HKD2_k127_8970538_46 Glutathione peroxidase K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000001025 228.0
HKD2_k127_8970538_47 PFAM regulatory protein TetR - - - 0.00000000000000000000000000000000000000000000000000000000000005702 237.0
HKD2_k127_8970538_48 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000006517 209.0
HKD2_k127_8970538_49 Protein of unknown function (DUF3833) - - - 0.000000000000000000000000000000000000000000000000000000001745 223.0
HKD2_k127_8970538_5 Male sterility protein - - - 1.006e-284 889.0
HKD2_k127_8970538_50 outer membrane porin, OprD family - - - 0.000000000000000000000000000000000000000000000000000000002772 216.0
HKD2_k127_8970538_51 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000001255 209.0
HKD2_k127_8970538_52 - - - - 0.00000000000000000000000000000000000000000000006715 188.0
HKD2_k127_8970538_53 Thioesterase superfamily K10806 - - 0.00000000000000000000000000000000000000000000008151 171.0
HKD2_k127_8970538_54 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000001853 182.0
HKD2_k127_8970538_55 SnoaL-like domain K01822 - 5.3.3.1 0.000000000000000000000000000000000000000009551 166.0
HKD2_k127_8970538_56 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000002233 164.0
HKD2_k127_8970538_57 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000005729 160.0
HKD2_k127_8970538_58 PGAP1-like protein - - - 0.0000000000000000000000000000000000000006915 161.0
HKD2_k127_8970538_59 PFAM response regulator receiver K11443 - - 0.0000000000000000000000000000000000004155 145.0
HKD2_k127_8970538_6 Fumarate lyase K01744 - 4.3.1.1 6.685e-264 822.0
HKD2_k127_8970538_60 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000009512 144.0
HKD2_k127_8970538_61 - - - - 0.0000000000000000000000000000000002192 139.0
HKD2_k127_8970538_62 Ferredoxin K05337 - - 0.00000000000000000000000000000003532 128.0
HKD2_k127_8970538_63 PFAM poly granule associated family protein - - - 0.000000000000000000000000001974 119.0
HKD2_k127_8970538_64 PFAM acyl-coA-binding protein, ACBP - - - 0.000000000000000000000002086 105.0
HKD2_k127_8970538_65 CBS domain - - - 0.000000000000000000003545 99.0
HKD2_k127_8970538_66 polyhydroxyalkanoic acid system protein - - - 0.0000000000007431 83.0
HKD2_k127_8970538_67 PFAM CBS domain containing protein - - - 0.00000004638 62.0
HKD2_k127_8970538_7 PFAM Malic enzyme, NAD binding domain K00029 - 1.1.1.40 7.251e-261 814.0
HKD2_k127_8970538_8 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.643e-255 799.0
HKD2_k127_8970538_9 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 2.22e-249 786.0
HKD2_k127_9006361_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 9.53e-202 640.0
HKD2_k127_9006361_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 530.0
HKD2_k127_9006361_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000008605 161.0
HKD2_k127_9006361_11 Tetratricopeptide repeat - - - 0.000000001807 70.0
HKD2_k127_9006361_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 466.0
HKD2_k127_9006361_3 Membrane-bound lytic murein transglycosylase K08304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005379 423.0
HKD2_k127_9006361_4 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 356.0
HKD2_k127_9006361_5 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 302.0
HKD2_k127_9006361_6 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002449 286.0
HKD2_k127_9006361_7 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000009839 203.0
HKD2_k127_9006361_8 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000008138 199.0
HKD2_k127_9006361_9 ApaG domain - - - 0.00000000000000000000000000000000000000000000000000002667 190.0
HKD2_k127_9014515_0 Biotin carboxylase C-terminal domain K01965 - 6.4.1.3 4.385e-297 950.0
HKD2_k127_9014515_1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 6.081e-290 896.0
HKD2_k127_9014515_10 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 551.0
HKD2_k127_9014515_11 Saccharopine dehydrogenase K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 535.0
HKD2_k127_9014515_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 544.0
HKD2_k127_9014515_13 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 486.0
HKD2_k127_9014515_14 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 428.0
HKD2_k127_9014515_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 461.0
HKD2_k127_9014515_16 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 407.0
HKD2_k127_9014515_17 TIGRFAM LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 396.0
HKD2_k127_9014515_18 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 388.0
HKD2_k127_9014515_19 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 377.0
HKD2_k127_9014515_2 Belongs to the IlvD Edd family - - - 5.423e-279 866.0
HKD2_k127_9014515_20 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 329.0
HKD2_k127_9014515_21 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 323.0
HKD2_k127_9014515_22 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 311.0
HKD2_k127_9014515_23 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 319.0
HKD2_k127_9014515_24 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 298.0
HKD2_k127_9014515_25 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000003493 254.0
HKD2_k127_9014515_26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000008294 258.0
HKD2_k127_9014515_27 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004423 248.0
HKD2_k127_9014515_28 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000002806 192.0
HKD2_k127_9014515_29 Protein of unknown function (DUF3530) - - - 0.00000000000000000000000000000000000000000000004068 193.0
HKD2_k127_9014515_3 TIGRFAM glutamine synthetase, type I K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 3.739e-263 818.0
HKD2_k127_9014515_30 TIGRFAM MJ0042 family finger-like protein - - - 0.0000000000000000000000000000000000000000004424 168.0
HKD2_k127_9014515_32 Thioredoxin-like - - - 0.000000000000000000000000000000000000005592 151.0
HKD2_k127_9014515_33 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000317 141.0
HKD2_k127_9014515_34 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000000000000001026 151.0
HKD2_k127_9014515_35 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000001203 131.0
HKD2_k127_9014515_36 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.00000000000000000000000000000001653 136.0
HKD2_k127_9014515_37 of cations and cationic drugs K03297 - - 0.00000000000000000000000000000008357 127.0
HKD2_k127_9014515_38 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000638 124.0
HKD2_k127_9014515_39 sodium ion export across plasma membrane K01573 GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234 4.1.1.3 0.0000000000000000000000000002806 117.0
HKD2_k127_9014515_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 2.694e-254 793.0
HKD2_k127_9014515_40 CoA carboxylase activity K01615,K01965,K02160,K17490 - 2.1.3.1,4.1.1.70,6.4.1.3 0.00000000000000000009241 104.0
HKD2_k127_9014515_41 Transcriptional regulator - - - 0.000000000000000006994 94.0
HKD2_k127_9014515_42 Domain of unknown function (DUF4124) - - - 0.00000000000000001298 91.0
HKD2_k127_9014515_43 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.00000000002168 71.0
HKD2_k127_9014515_45 - - - - 0.000000007179 66.0
HKD2_k127_9014515_5 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 3.844e-247 769.0
HKD2_k127_9014515_6 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - 1.718e-241 762.0
HKD2_k127_9014515_7 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.69e-230 721.0
HKD2_k127_9014515_8 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 623.0
HKD2_k127_9014515_9 oxaloacetate decarboxylase activity K01572 - 4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 593.0
HKD2_k127_9061262_0 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 2e-323 1003.0
HKD2_k127_9061262_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 531.0
HKD2_k127_9061262_10 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000008429 192.0
HKD2_k127_9061262_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 472.0
HKD2_k127_9061262_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 430.0
HKD2_k127_9061262_4 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 331.0
HKD2_k127_9061262_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 321.0
HKD2_k127_9061262_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 301.0
HKD2_k127_9061262_7 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 296.0
HKD2_k127_9061262_8 Sulfate permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003201 292.0
HKD2_k127_9061262_9 amino acid transport system, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003598 263.0
HKD2_k127_9091610_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 2.345e-217 688.0
HKD2_k127_9091610_1 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000009682 234.0
HKD2_k127_9091610_2 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.0000000000000000000000000000000000000000000000000000000000006468 215.0
HKD2_k127_9091610_3 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000004995 176.0
HKD2_k127_9091610_4 serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000003249 146.0
HKD2_k127_9093533_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 7.563e-285 894.0
HKD2_k127_9093533_1 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 606.0
HKD2_k127_9158231_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 2.63e-279 895.0
HKD2_k127_9158231_1 Tripartite ATP-independent periplasmic transporter, DctM component K11690 - - 1.868e-218 683.0
HKD2_k127_9158231_10 - - - - 0.000000000000000000000000000000000000007205 154.0
HKD2_k127_9158231_12 DNA polymerase family A - - - 0.0000000000007549 70.0
HKD2_k127_9158231_13 Urocanase C-terminal domain - - - 0.000005945 49.0
HKD2_k127_9158231_2 Carbohydrate transport and metabolism K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 600.0
HKD2_k127_9158231_3 Catalyzes the degradation of histidine to urocanate and ammmonia K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 574.0
HKD2_k127_9158231_4 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 428.0
HKD2_k127_9158231_5 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 433.0
HKD2_k127_9158231_6 Phage integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 361.0
HKD2_k127_9158231_7 Tripartite ATP-independent periplasmic transporter dctq component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002673 252.0
HKD2_k127_9158231_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001372 258.0
HKD2_k127_9158231_9 Two component transcriptional regulator, LuxR family K13041 - - 0.00000000000000000000000000000000000000000000009758 183.0
HKD2_k127_9184892_0 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 541.0
HKD2_k127_9184892_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 469.0
HKD2_k127_9261283_0 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 1.444e-205 646.0
HKD2_k127_9261283_1 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 615.0
HKD2_k127_9261283_2 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 505.0
HKD2_k127_9261283_3 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 392.0
HKD2_k127_9261283_4 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 289.0
HKD2_k127_9261283_5 COG3090 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000000000000000000000000000000000007667 204.0
HKD2_k127_9274937_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1469.0
HKD2_k127_9274937_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 9.456e-321 990.0
HKD2_k127_9274937_10 CRS1_YhbY K07574 - - 0.00000000000000000000000000005837 130.0
HKD2_k127_9274937_11 O-methyltransferase K09846 - 2.1.1.210 0.000005563 50.0
HKD2_k127_9274937_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 564.0
HKD2_k127_9274937_3 Pterin binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 322.0
HKD2_k127_9274937_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 303.0
HKD2_k127_9274937_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 303.0
HKD2_k127_9274937_6 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 291.0
HKD2_k127_9274937_7 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000001685 256.0
HKD2_k127_9274937_8 Transcription elongation factor, N-terminal K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000002331 231.0
HKD2_k127_9274937_9 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000000000007918 208.0
HKD2_k127_9355645_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 6.611e-299 925.0
HKD2_k127_9355645_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 9.887e-210 671.0
HKD2_k127_9355645_10 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000002063 270.0
HKD2_k127_9355645_11 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000412 256.0
HKD2_k127_9355645_12 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000000008045 164.0
HKD2_k127_9355645_13 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.00000000000006131 79.0
HKD2_k127_9355645_14 Lipopolysaccharide assembly protein A domain K08992 - - 0.00000006991 61.0
HKD2_k127_9355645_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 601.0
HKD2_k127_9355645_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 479.0
HKD2_k127_9355645_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 461.0
HKD2_k127_9355645_5 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 451.0
HKD2_k127_9355645_6 chorismate mutase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 427.0
HKD2_k127_9355645_7 pfkB family carbohydrate kinase K03272,K21344 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 413.0
HKD2_k127_9355645_8 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004993 368.0
HKD2_k127_9355645_9 prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000852 290.0
HKD2_k127_9418270_0 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1146.0
HKD2_k127_9418270_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 6.37e-322 994.0
HKD2_k127_9418270_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 322.0
HKD2_k127_9418270_11 Sigma E regulatory protein, MucB RseB K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001146 252.0
HKD2_k127_9418270_12 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.000000000000000008804 96.0
HKD2_k127_9418270_13 COG0526 Thiol-disulfide isomerase and thioredoxins K00384 - 1.8.1.9 0.00000000000000001129 87.0
HKD2_k127_9418270_14 Domain of unknown function (DUF4845) - - - 0.0000000000004919 76.0
HKD2_k127_9418270_2 PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A K01908 - 6.2.1.17 6.5e-317 1001.0
HKD2_k127_9418270_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 1.21e-229 722.0
HKD2_k127_9418270_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 561.0
HKD2_k127_9418270_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 523.0
HKD2_k127_9418270_6 AFG1-like ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 417.0
HKD2_k127_9418270_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 372.0
HKD2_k127_9418270_8 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 347.0
HKD2_k127_9418270_9 PFAM Peptidase S24 S26A S26B, conserved region K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 333.0
HKD2_k127_9468465_0 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 1.103e-212 681.0
HKD2_k127_9468465_1 Permease family K02824 - - 2.261e-209 662.0
HKD2_k127_9468465_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 351.0
HKD2_k127_9468465_11 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 349.0
HKD2_k127_9468465_12 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 323.0
HKD2_k127_9468465_13 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000093 271.0
HKD2_k127_9468465_14 catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000003231 250.0
HKD2_k127_9468465_15 Protein of unknown function, DUF480 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001387 247.0
HKD2_k127_9468465_16 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000004294 200.0
HKD2_k127_9468465_17 Aspartyl protease - - - 0.00000000000000000000000000000000000000000000000000004193 211.0
HKD2_k127_9468465_18 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000000000000000000000005343 184.0
HKD2_k127_9468465_19 peptide chain release factor K15034 - - 0.000000000000000000000000000000000000000000004552 169.0
HKD2_k127_9468465_2 Dehydratase large subunit K01699,K06120 - 4.2.1.28,4.2.1.30 7.035e-206 667.0
HKD2_k127_9468465_20 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000002865 183.0
HKD2_k127_9468465_21 Dehydratase K13919 - 4.2.1.28 0.000000000000000000000000000000000000000003979 178.0
HKD2_k127_9468465_22 Transcription factor zinc-finger - - - 0.00000000000000000000000000000000000000002289 162.0
HKD2_k127_9468465_23 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000004907 153.0
HKD2_k127_9468465_24 iron ion homeostasis - - - 0.00000000000000000000000000000000000004609 154.0
HKD2_k127_9468465_25 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.0000000000000000000000001537 112.0
HKD2_k127_9468465_26 domain, Protein - - - 0.0000000000000000000000003884 108.0
HKD2_k127_9468465_27 Dehydratase small subunit K06122,K13920 - 4.2.1.28,4.2.1.30 0.000000000000000000001327 103.0
HKD2_k127_9468465_28 iron ion homeostasis - - - 0.000000000000000003641 83.0
HKD2_k127_9468465_29 - - - - 0.0000002852 64.0
HKD2_k127_9468465_3 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 599.0
HKD2_k127_9468465_30 Protein of unknown function (DUF3149) - - - 0.0004793 45.0
HKD2_k127_9468465_31 Periplasmic Protein - GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772 - 0.0005907 48.0
HKD2_k127_9468465_4 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 520.0
HKD2_k127_9468465_5 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 471.0
HKD2_k127_9468465_6 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 449.0
HKD2_k127_9468465_7 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 471.0
HKD2_k127_9468465_8 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 399.0
HKD2_k127_9468465_9 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 360.0
HKD2_k127_9470199_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 3.807e-272 849.0
HKD2_k127_9470199_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 8.499e-223 694.0
HKD2_k127_9470199_2 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003957 240.0
HKD2_k127_9470199_3 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.000000000000000000000000000000000000000000000000000000000000002142 221.0
HKD2_k127_9470199_4 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000000006247 193.0
HKD2_k127_9470199_5 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.0000000000000000000000000000000000000000000005007 178.0
HKD2_k127_9470199_6 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000009574 136.0
HKD2_k127_9470199_7 Iron-sulphur cluster assembly - - - 0.0000000000000000000000000003569 115.0
HKD2_k127_9470199_8 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000008906 91.0
HKD2_k127_9470199_9 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.00006935 45.0
HKD2_k127_9478369_0 glycosyl transferase family 2 K20444 - - 4.581e-207 663.0
HKD2_k127_9478369_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 409.0
HKD2_k127_9478369_2 Coenzyme A transferase K01026 - 2.8.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 344.0
HKD2_k127_9478369_3 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 317.0
HKD2_k127_9478369_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000002079 209.0
HKD2_k127_9478369_5 thiamine biosynthesis protein ThiS K03154 - - 0.00000000000000001225 87.0
HKD2_k127_9478369_6 Putative zinc-finger - - - 0.0000004241 55.0
HKD2_k127_9478614_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.966e-219 685.0
HKD2_k127_9478614_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 570.0
HKD2_k127_9478614_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 505.0
HKD2_k127_9478614_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 462.0
HKD2_k127_9478614_4 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 345.0
HKD2_k127_9478614_5 Squalene synthase HpnD K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 377.0
HKD2_k127_9478614_6 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 293.0
HKD2_k127_9478614_7 squalene-associated FAD-dependent desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004728 278.0
HKD2_k127_9478614_8 Short-chain dehydrogenase reductase (SDR) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001207 269.0
HKD2_k127_9478614_9 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.000000000000002111 76.0
HKD2_k127_9521143_0 Belongs to the argininosuccinate synthase family. Type 2 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.663e-244 762.0
HKD2_k127_9521143_1 Patatin-like phospholipase K07001 - - 1.398e-222 708.0
HKD2_k127_9521143_2 Cysteine-rich domain - - - 2.001e-208 658.0
HKD2_k127_9521143_3 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 561.0
HKD2_k127_9521143_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 488.0
HKD2_k127_9521143_5 Molybdopterin biosynthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 476.0
HKD2_k127_9521143_6 Lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 389.0
HKD2_k127_9521143_7 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000009109 265.0
HKD2_k127_9521143_8 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001734 256.0
HKD2_k127_9521143_9 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000002082 159.0
HKD2_k127_9639403_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K15509 - 1.1.1.308 1.377e-224 702.0
HKD2_k127_9639403_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00166 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 615.0
HKD2_k127_9639403_10 Outer membrane usher protein K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 426.0
HKD2_k127_9639403_11 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 362.0
HKD2_k127_9639403_12 PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 360.0
HKD2_k127_9639403_13 KR domain K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 325.0
HKD2_k127_9639403_14 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002909 270.0
HKD2_k127_9639403_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002818 277.0
HKD2_k127_9639403_16 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000001321 258.0
HKD2_k127_9639403_17 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000691 219.0
HKD2_k127_9639403_18 Protein of unknown function DUF126 K09128 - - 0.00000000000000000000000000000000000000000000000000191 201.0
HKD2_k127_9639403_19 GntR family transcriptional regulator K03486,K03710 - - 0.000000000000000000000000000000000000000006189 169.0
HKD2_k127_9639403_2 Transketolase, C-terminal domain K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 612.0
HKD2_k127_9639403_20 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000332 147.0
HKD2_k127_9639403_21 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000001078 116.0
HKD2_k127_9639403_22 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.0000000000000000000005527 105.0
HKD2_k127_9639403_23 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000003958 96.0
HKD2_k127_9639403_24 Spore Coat Protein U domain - - - 0.0000000000002092 78.0
HKD2_k127_9639403_25 Spore Coat Protein U domain - - - 0.0003402 51.0
HKD2_k127_9639403_3 Conserved carboxylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 579.0
HKD2_k127_9639403_4 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 563.0
HKD2_k127_9639403_5 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 528.0
HKD2_k127_9639403_6 2-oxoacid ferredoxin oxidoreductase, alpha subunit K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 506.0
HKD2_k127_9639403_7 e3 binding domain K09699 - 2.3.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 484.0
HKD2_k127_9639403_8 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 463.0
HKD2_k127_9639403_9 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 411.0
HKD2_k127_9660068_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 423.0
HKD2_k127_9660068_1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008528 300.0
HKD2_k127_9660068_2 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000003619 88.0
HKD2_k127_9668151_0 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 4.689e-266 837.0
HKD2_k127_9668151_1 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 3.618e-208 659.0
HKD2_k127_9668151_10 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 432.0
HKD2_k127_9668151_11 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 430.0
HKD2_k127_9668151_12 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 426.0
HKD2_k127_9668151_13 THUMP K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 409.0
HKD2_k127_9668151_14 Binding-protein-dependent transport system inner membrane component K11070,K11074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 376.0
HKD2_k127_9668151_15 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007839 329.0
HKD2_k127_9668151_16 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 348.0
HKD2_k127_9668151_17 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 314.0
HKD2_k127_9668151_18 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 314.0
HKD2_k127_9668151_19 KR domain K10780 - 1.3.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 305.0
HKD2_k127_9668151_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 3.157e-207 659.0
HKD2_k127_9668151_20 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001695 272.0
HKD2_k127_9668151_21 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000002918 252.0
HKD2_k127_9668151_22 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000001308 247.0
HKD2_k127_9668151_23 Serine aminopeptidase, S33 K07018 - - 0.000000000000000000000000000000000000000000000000000000000000001488 229.0
HKD2_k127_9668151_24 lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000504 242.0
HKD2_k127_9668151_25 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000154 212.0
HKD2_k127_9668151_26 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000001062 224.0
HKD2_k127_9668151_27 Histidine kinase K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000006566 183.0
HKD2_k127_9668151_28 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.0000000000000000000000000000000000000000003077 173.0
HKD2_k127_9668151_29 Ferredoxin - - - 0.0000000000000000000000000000000000000000005575 161.0
HKD2_k127_9668151_3 Organic solvent tolerance protein K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 580.0
HKD2_k127_9668151_30 Phosphopantetheine attachment site - - - 0.0000000000000000000000000000000000000009568 151.0
HKD2_k127_9668151_31 Belongs to the acetyltransferase family. ArgA subfamily K03830 - - 0.0000000000000000000000000000000000007907 147.0
HKD2_k127_9668151_32 VanZ like family - - - 0.00000000000000000000000000000000001441 149.0
HKD2_k127_9668151_33 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000000001647 134.0
HKD2_k127_9668151_34 FabA-like domain - - - 0.0000000000000000000003416 106.0
HKD2_k127_9668151_35 Phospholipid methyltransferase - - - 0.0000000000004071 83.0
HKD2_k127_9668151_4 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069,K11073 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 534.0
HKD2_k127_9668151_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 524.0
HKD2_k127_9668151_6 PFAM membrane bound O-acyl transferase MBOAT K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 478.0
HKD2_k127_9668151_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 456.0
HKD2_k127_9668151_8 Binding-protein-dependent transport system inner membrane component K02054,K11071,K11075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 437.0
HKD2_k127_9668151_9 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 443.0
HKD2_k127_9714236_0 FAD linked oxidase domain protein - - - 0.0 1803.0
HKD2_k127_9714236_1 DNA topoisomerase III K03169 - 5.99.1.2 0.0 1148.0
HKD2_k127_9714236_10 Magnesium chelatase, subunit ChlI K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 616.0
HKD2_k127_9714236_11 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007511 627.0
HKD2_k127_9714236_12 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 599.0
HKD2_k127_9714236_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 579.0
HKD2_k127_9714236_14 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 548.0
HKD2_k127_9714236_15 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 504.0
HKD2_k127_9714236_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 496.0
HKD2_k127_9714236_17 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 495.0
HKD2_k127_9714236_18 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 425.0
HKD2_k127_9714236_19 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 408.0
HKD2_k127_9714236_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 3.188e-280 874.0
HKD2_k127_9714236_20 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000899 395.0
HKD2_k127_9714236_21 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 422.0
HKD2_k127_9714236_22 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006782 399.0
HKD2_k127_9714236_23 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 374.0
HKD2_k127_9714236_24 SMART Tetratricopeptide domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 376.0
HKD2_k127_9714236_25 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 356.0
HKD2_k127_9714236_26 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 350.0
HKD2_k127_9714236_27 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 355.0
HKD2_k127_9714236_28 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 334.0
HKD2_k127_9714236_29 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007749 316.0
HKD2_k127_9714236_3 FtsX-like permease family K02004 - - 9.519e-245 792.0
HKD2_k127_9714236_30 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 327.0
HKD2_k127_9714236_31 ABC transporter K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 312.0
HKD2_k127_9714236_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 299.0
HKD2_k127_9714236_33 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 304.0
HKD2_k127_9714236_34 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 312.0
HKD2_k127_9714236_35 PFAM Peptidoglycan-binding LysM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001643 292.0
HKD2_k127_9714236_36 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001856 287.0
HKD2_k127_9714236_37 GHMP kinases N terminal domain K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002219 277.0
HKD2_k127_9714236_38 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001396 271.0
HKD2_k127_9714236_39 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00127,K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000004429 240.0
HKD2_k127_9714236_4 Transport of potassium into the cell K03549 - - 2.702e-244 769.0
HKD2_k127_9714236_40 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000001635 241.0
HKD2_k127_9714236_41 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000003484 228.0
HKD2_k127_9714236_42 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000006966 227.0
HKD2_k127_9714236_43 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000001195 226.0
HKD2_k127_9714236_44 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000793 222.0
HKD2_k127_9714236_45 PFAM DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000002904 215.0
HKD2_k127_9714236_46 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000005698 211.0
HKD2_k127_9714236_47 protein conserved in bacteria K09921 - - 0.0000000000000000000000000000000000000000000000000000000002864 211.0
HKD2_k127_9714236_48 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000000000000000003441 205.0
HKD2_k127_9714236_49 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000006982 170.0
HKD2_k127_9714236_5 Dynamin family - - - 1.006e-223 711.0
HKD2_k127_9714236_50 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000008144 169.0
HKD2_k127_9714236_51 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000008463 162.0
HKD2_k127_9714236_52 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000002321 148.0
HKD2_k127_9714236_53 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000001434 162.0
HKD2_k127_9714236_54 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000005789 127.0
HKD2_k127_9714236_55 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000000000000000002973 121.0
HKD2_k127_9714236_56 Protein of unknown function (DUF2905) - - - 0.000000000000000000000001011 104.0
HKD2_k127_9714236_57 Membrane fusogenic activity K09806 - - 0.0000000000000000000003454 98.0
HKD2_k127_9714236_59 cyclic nucleotide binding K10914 - - 0.00000000000000003858 86.0
HKD2_k127_9714236_6 Ammonium transporter K03320 - - 7.045e-222 704.0
HKD2_k127_9714236_60 PFAM MAPEG family - - - 0.0000001528 55.0
HKD2_k127_9714236_61 Cytochrome c - - - 0.0000002642 58.0
HKD2_k127_9714236_62 Late embryogenesis abundant protein - - - 0.00002369 57.0
HKD2_k127_9714236_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 6.533e-220 695.0
HKD2_k127_9714236_8 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 5.319e-211 666.0
HKD2_k127_9714236_9 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 1.297e-208 655.0
HKD2_k127_97942_0 Acetolactate synthase K01577,K01652,K03852 - 2.2.1.6,2.3.3.15,4.1.1.8 4.767e-290 915.0
HKD2_k127_97942_1 Aldehyde dehydrogenase family K04072,K13922 - 1.1.1.1,1.2.1.10,1.2.1.87 5.595e-242 772.0
HKD2_k127_97942_10 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000006486 264.0
HKD2_k127_97942_11 helix_turn_helix isocitrate lyase regulation K02624 - - 0.00000000000000000000000000000000000000000000000000000000000000000002903 243.0
HKD2_k127_97942_12 Tripartite ATP-independent periplasmic transporters, DctQ component K11689,K21394 - - 0.0000000000000000000000000000000000000000000000000000002532 202.0
HKD2_k127_97942_13 TIGRFAM TRAP dicarboxylate transporter, DctP subunit K21395 - - 0.00000000000000000000000000000000000000001708 158.0
HKD2_k127_97942_14 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.0000000000000007925 78.0
HKD2_k127_97942_2 Tripartite ATP-independent periplasmic transporter, DctM component K21393 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 607.0
HKD2_k127_97942_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 607.0
HKD2_k127_97942_4 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007142 417.0
HKD2_k127_97942_5 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 399.0
HKD2_k127_97942_6 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 392.0
HKD2_k127_97942_7 citrate synthase K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 364.0
HKD2_k127_97942_8 Xylose isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 350.0
HKD2_k127_97942_9 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 293.0
HKD2_k127_9818725_0 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 323.0
HKD2_k127_9818725_1 MOSC N-terminal beta barrel domain K07140 - - 0.0000000000000000000000000000000000000000000000000000000000000000001557 241.0
HKD2_k127_9818725_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000005324 206.0
HKD2_k127_9818725_3 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000001619 181.0
HKD2_k127_9818725_4 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000003852 180.0
HKD2_k127_9855583_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.971e-234 737.0
HKD2_k127_9855583_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 479.0
HKD2_k127_9855583_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000206 99.0
HKD2_k127_9858788_0 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 426.0
HKD2_k127_9858788_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 428.0
HKD2_k127_9858788_2 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 424.0
HKD2_k127_9858788_3 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002963 253.0
HKD2_k127_9858788_4 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000002294 176.0
HKD2_k127_9945813_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 517.0
HKD2_k127_9945813_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003238 273.0
HKD2_k127_9945813_2 oxidoreductase gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000001769 172.0