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Overview

ID MAG01825
Name HKD2_bin.87
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Rariloculales
Family Rariloculaceae
Genus FEN-1219
Species
Assembly information
Completeness (%) 80.29
Contamination (%) 1.56
GC content (%) 68.0
N50 (bp) 16,513
Genome size (bp) 3,267,824

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2922

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10003124_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000004648 225.0
HKD2_k127_10003124_1 - - - - 0.000000000000000000000000000000000000000000000001782 190.0
HKD2_k127_10003124_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000001792 81.0
HKD2_k127_10057130_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 6.249e-213 683.0
HKD2_k127_10057130_1 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 600.0
HKD2_k127_10057130_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000001538 264.0
HKD2_k127_10057130_3 ATP-dependent helicase K03578 - 3.6.4.13 0.000000000009785 66.0
HKD2_k127_10087582_0 PQQ enzyme repeat K00117 - 1.1.5.2 6.848e-196 632.0
HKD2_k127_10087582_1 Dihydroxyacetone kinase K00863 - 2.7.1.28,2.7.1.29,4.6.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 345.0
HKD2_k127_10087582_2 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000001654 176.0
HKD2_k127_10087582_3 - - - - 0.000000000000000000000000000000000000001472 162.0
HKD2_k127_10087582_4 carboxylic ester hydrolase activity K03929 - - 0.00000000000000000000000000000000000003798 153.0
HKD2_k127_10089199_0 Belongs to the aldehyde dehydrogenase family K00151 - 1.2.1.60 6.908e-221 696.0
HKD2_k127_10089199_1 Surface antigen variable number K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 446.0
HKD2_k127_10089199_2 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04101,K05713 - 1.13.11.16,1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 407.0
HKD2_k127_10089199_3 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.0000000000000000000000000000001785 125.0
HKD2_k127_10089199_4 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.00000000000000000000004642 102.0
HKD2_k127_10089199_5 protein conserved in bacteria K09800 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - 0.000000001075 71.0
HKD2_k127_10099925_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 582.0
HKD2_k127_10099925_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000001366 192.0
HKD2_k127_10099925_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000014 155.0
HKD2_k127_10099925_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000006104 146.0
HKD2_k127_10099925_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000000006228 114.0
HKD2_k127_10117947_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 450.0
HKD2_k127_10117947_1 The M ring may be actively involved in energy transduction K02409 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 441.0
HKD2_k127_10117947_2 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 339.0
HKD2_k127_10117947_3 Histidine kinase K10942 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000003013 239.0
HKD2_k127_10117947_4 Flagellar hook-basal body complex protein FliE K02408 - - 0.000000000000000003409 90.0
HKD2_k127_10128395_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 408.0
HKD2_k127_10128395_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 402.0
HKD2_k127_10128395_2 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 347.0
HKD2_k127_10128395_3 electron transfer flavoprotein beta subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 315.0
HKD2_k127_10128395_4 Alkyl hydroperoxide reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000002078 230.0
HKD2_k127_10128395_5 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000006803 111.0
HKD2_k127_10138334_0 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 5.975e-237 745.0
HKD2_k127_10138334_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 - 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 622.0
HKD2_k127_10138334_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000005695 208.0
HKD2_k127_10138334_11 Pilin (bacterial filament) K02650,K02655 - - 0.00000000000000000000000000000000000000000000000000379 186.0
HKD2_k127_10138334_12 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000001392 187.0
HKD2_k127_10138334_13 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000002811 134.0
HKD2_k127_10138334_14 Pilin (bacterial filament) K02650,K02655 - - 0.0000000000000000002817 95.0
HKD2_k127_10138334_15 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000000001811 66.0
HKD2_k127_10138334_2 PFAM response regulator receiver K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 537.0
HKD2_k127_10138334_3 Type II secretory pathway, component PulF K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 505.0
HKD2_k127_10138334_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 494.0
HKD2_k127_10138334_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 440.0
HKD2_k127_10138334_6 Histidine kinase K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 374.0
HKD2_k127_10138334_7 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 334.0
HKD2_k127_10138334_8 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 317.0
HKD2_k127_10138334_9 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000007387 209.0
HKD2_k127_1059370_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008464 421.0
HKD2_k127_1059370_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003422 237.0
HKD2_k127_1059370_2 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000306 203.0
HKD2_k127_1059370_3 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000000191 179.0
HKD2_k127_1059370_4 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase - - - 0.0000000000000000000000000000000000006681 148.0
HKD2_k127_1059370_5 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - 0.000000000000000008168 96.0
HKD2_k127_1065036_0 Radical SAM - - - 9.189e-196 634.0
HKD2_k127_1065036_10 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000007236 159.0
HKD2_k127_1065036_11 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000003552 151.0
HKD2_k127_1065036_12 Flagellar motor protein K02557 - - 0.000000000000000000000000002551 122.0
HKD2_k127_1065036_13 MotA TolQ ExbB proton channel K02556 - - 0.000000000000000000003485 97.0
HKD2_k127_1065036_14 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000007569 57.0
HKD2_k127_1065036_15 Methyltransferase FkbM domain - - - 0.00003674 54.0
HKD2_k127_1065036_2 Mg-protoporphyrin IX monomethyl ester oxidative cyclase K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 402.0
HKD2_k127_1065036_3 Hexosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 392.0
HKD2_k127_1065036_4 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 390.0
HKD2_k127_1065036_5 glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 367.0
HKD2_k127_1065036_6 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 337.0
HKD2_k127_1065036_7 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 332.0
HKD2_k127_1065036_8 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000002668 208.0
HKD2_k127_1065036_9 radical SAM domain protein K06137,K06138 - 1.3.3.11 0.000000000000000000000000000000000000000000000002218 189.0
HKD2_k127_1086405_0 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 3.624e-226 726.0
HKD2_k127_1086405_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018,K00058,K03778 - 1.1.1.28,1.1.1.29,1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 427.0
HKD2_k127_1086405_10 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000009636 144.0
HKD2_k127_1086405_11 - - - - 0.00000000000000000000002155 112.0
HKD2_k127_1086405_12 cytochrome - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000003864 79.0
HKD2_k127_1086405_13 Peptidase family S51 - - - 0.0000000000004866 80.0
HKD2_k127_1086405_2 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 404.0
HKD2_k127_1086405_3 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 396.0
HKD2_k127_1086405_4 PFAM EAL domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 368.0
HKD2_k127_1086405_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 302.0
HKD2_k127_1086405_6 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006045 272.0
HKD2_k127_1086405_7 2Fe-2S -binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004294 247.0
HKD2_k127_1086405_8 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000001743 196.0
HKD2_k127_1086405_9 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.00000000000000000000000000000000000000004475 154.0
HKD2_k127_1123691_0 Participates in both transcription termination and antitermination K02600 - - 5.195e-218 687.0
HKD2_k127_1123691_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 548.0
HKD2_k127_1123691_10 ABC transporter K01990 - - 0.000000000724 63.0
HKD2_k127_1123691_2 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 426.0
HKD2_k127_1123691_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 406.0
HKD2_k127_1123691_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 297.0
HKD2_k127_1123691_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000006152 195.0
HKD2_k127_1123691_6 heme binding K08259 - 3.4.24.75 0.00000000000000000000000000000000000000000000000002101 190.0
HKD2_k127_1123691_7 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.00000000000000000000000000000000000000000000000003246 187.0
HKD2_k127_1123691_8 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000007941 139.0
HKD2_k127_1123691_9 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000004821 117.0
HKD2_k127_125685_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 461.0
HKD2_k127_125685_1 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000007147 190.0
HKD2_k127_125685_2 Bacterial protein of unknown function (DUF882) - - - 0.000000000000000000000000000000000000000000000006166 179.0
HKD2_k127_125685_3 Surface antigen variable number K07001 - - 0.0000000000000000000000001906 110.0
HKD2_k127_1356260_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.158e-318 1022.0
HKD2_k127_1356260_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.444e-285 890.0
HKD2_k127_1356260_10 Major facilitator superfamily K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 371.0
HKD2_k127_1356260_11 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 364.0
HKD2_k127_1356260_12 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 346.0
HKD2_k127_1356260_13 Bacterial regulatory helix-turn-helix protein, lysR family K04761 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 344.0
HKD2_k127_1356260_14 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 298.0
HKD2_k127_1356260_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001115 298.0
HKD2_k127_1356260_16 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000107 274.0
HKD2_k127_1356260_17 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001261 260.0
HKD2_k127_1356260_18 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000112 239.0
HKD2_k127_1356260_19 belongs to the bacterial solute-binding protein 3 family K02030,K02424,K10036 - - 0.0000000000000000000000000000000000000000000000000000000000000000332 237.0
HKD2_k127_1356260_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.016e-232 734.0
HKD2_k127_1356260_20 Transcriptional K03719 - - 0.000000000000000000000000000000000000000000000000000000000000009464 220.0
HKD2_k127_1356260_21 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000001349 215.0
HKD2_k127_1356260_22 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000001657 208.0
HKD2_k127_1356260_23 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000009815 194.0
HKD2_k127_1356260_24 domain protein - - - 0.00000000000000000000000000000000000000000000002696 183.0
HKD2_k127_1356260_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000001105 170.0
HKD2_k127_1356260_26 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.00000000000000000000000000000000000000000003253 175.0
HKD2_k127_1356260_27 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000005481 161.0
HKD2_k127_1356260_28 Belongs to the flagella basal body rod proteins family K02388 - - 0.0000000000000000000000000000000000000009314 162.0
HKD2_k127_1356260_29 Flagellar hook protein FlgE K02390 - - 0.0000000000000000000000000000000001103 147.0
HKD2_k127_1356260_3 Aminotransferase class I and II K00812 - 2.6.1.1 5.267e-211 672.0
HKD2_k127_1356260_30 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000000000006786 126.0
HKD2_k127_1356260_31 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.00000000000000000000001543 115.0
HKD2_k127_1356260_32 helix_turn_helix multiple antibiotic resistance protein - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000746 85.0
HKD2_k127_1356260_33 DsrE/DsrF-like family - - - 0.000000000000002132 85.0
HKD2_k127_1356260_34 PilZ domain - - - 0.00000000000003607 75.0
HKD2_k127_1356260_35 negative regulation of translational initiation - - - 0.00000000000005811 79.0
HKD2_k127_1356260_36 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678 - 0.000000000106 73.0
HKD2_k127_1356260_37 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000002237 65.0
HKD2_k127_1356260_38 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000007024 71.0
HKD2_k127_1356260_39 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - 0.000000004153 61.0
HKD2_k127_1356260_4 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 500.0
HKD2_k127_1356260_40 Flagellar biosynthesis type III secretory pathway chaperone K02399 - - 0.000000007271 63.0
HKD2_k127_1356260_41 Flagellar protein K02398 - - 0.0000002242 56.0
HKD2_k127_1356260_42 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000938 62.0
HKD2_k127_1356260_5 transporter K02429 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 480.0
HKD2_k127_1356260_6 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 447.0
HKD2_k127_1356260_7 Lytic murein transglycosylase K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 456.0
HKD2_k127_1356260_8 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 419.0
HKD2_k127_1356260_9 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 363.0
HKD2_k127_136250_0 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 595.0
HKD2_k127_136250_1 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 359.0
HKD2_k127_136250_10 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000005181 198.0
HKD2_k127_136250_11 LysR substrate binding domain K05817 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000781 201.0
HKD2_k127_136250_12 Phosphoserine phosphatase - - - 0.000000000000000000000000000000000000000000000001235 190.0
HKD2_k127_136250_13 periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000004566 177.0
HKD2_k127_136250_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000001205 168.0
HKD2_k127_136250_15 - - - - 0.00000000000000000000000000000000219 143.0
HKD2_k127_136250_16 - - - - 0.000000000000000000000000317 121.0
HKD2_k127_136250_18 decarboxylase K01607 - 4.1.1.44 0.00000000000002412 86.0
HKD2_k127_136250_2 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 339.0
HKD2_k127_136250_3 FecCD transport family K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006933 343.0
HKD2_k127_136250_4 enterobactin catabolic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 302.0
HKD2_k127_136250_5 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 306.0
HKD2_k127_136250_6 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009577 251.0
HKD2_k127_136250_7 ATP-binding protein K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000003096 243.0
HKD2_k127_136250_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004737 243.0
HKD2_k127_136250_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000003528 229.0
HKD2_k127_1369627_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1171.0
HKD2_k127_1369627_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 521.0
HKD2_k127_1369627_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000055 292.0
HKD2_k127_1369627_3 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000006086 240.0
HKD2_k127_1369627_4 Metallo-beta-lactamase superfamily - - - 0.000009877 54.0
HKD2_k127_1488842_0 receptor K02014 - - 1.058e-315 985.0
HKD2_k127_1488842_1 COG4993 Glucose dehydrogenase - - - 5.113e-216 687.0
HKD2_k127_1488842_10 CHRD domain containing protein - - - 0.00001029 55.0
HKD2_k127_1488842_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 530.0
HKD2_k127_1488842_3 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 432.0
HKD2_k127_1488842_4 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 364.0
HKD2_k127_1488842_5 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 358.0
HKD2_k127_1488842_6 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006952 278.0
HKD2_k127_1488842_7 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000008756 245.0
HKD2_k127_1488842_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000008822 228.0
HKD2_k127_1488842_9 MerR, DNA binding K13639 - - 0.000000000000000000000000000000000000000000000000000000003405 203.0
HKD2_k127_1492067_0 Efflux pump membrane transporter K18299,K18902 - - 0.0 1183.0
HKD2_k127_1492067_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.039e-259 821.0
HKD2_k127_1492067_10 - - - - 0.00000000000000000000000000000000000000000000000001257 203.0
HKD2_k127_1492067_11 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000006819 176.0
HKD2_k127_1492067_12 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000005218 155.0
HKD2_k127_1492067_13 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000000007666 115.0
HKD2_k127_1492067_14 Putative transposase - - - 0.00000000000000000000002233 104.0
HKD2_k127_1492067_15 - - - - 0.00000000000000000000003391 103.0
HKD2_k127_1492067_16 - - - - 0.0000000000000000000002012 101.0
HKD2_k127_1492067_17 4-hydroxyphenylacetate K00483 - 1.14.14.9 0.000000000000000000001341 97.0
HKD2_k127_1492067_18 - - - - 0.0000000000000000004591 101.0
HKD2_k127_1492067_19 - - - - 0.000000000000000008743 94.0
HKD2_k127_1492067_2 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 421.0
HKD2_k127_1492067_20 PFAM Photosynthetic reaction centre cytochrome C subunit K13992 - - 0.00000000000000004514 93.0
HKD2_k127_1492067_21 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000008691 83.0
HKD2_k127_1492067_22 Putative restriction endonuclease - - - 0.00000000000000009898 83.0
HKD2_k127_1492067_23 SnoaL-like domain - - - 0.0000000001514 63.0
HKD2_k127_1492067_25 - - - - 0.0000000006494 66.0
HKD2_k127_1492067_26 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000001063 69.0
HKD2_k127_1492067_27 Putative transposase - - - 0.000000006679 63.0
HKD2_k127_1492067_3 Retinal pigment epithelial membrane protein K11159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 387.0
HKD2_k127_1492067_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18298,K18901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 370.0
HKD2_k127_1492067_5 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008234 351.0
HKD2_k127_1492067_7 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001111 276.0
HKD2_k127_1492067_8 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000008836 256.0
HKD2_k127_1492067_9 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000005133 242.0
HKD2_k127_15105_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 378.0
HKD2_k127_15105_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 359.0
HKD2_k127_15105_2 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000002575 207.0
HKD2_k127_15105_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000003782 73.0
HKD2_k127_1555024_0 Glycogen debranching enzyme N terminal - - - 8.076e-241 761.0
HKD2_k127_1555024_1 SMART alpha amylase, catalytic sub domain K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 586.0
HKD2_k127_1555024_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 380.0
HKD2_k127_1555024_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000002328 266.0
HKD2_k127_1582355_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1223.0
HKD2_k127_1582355_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.112e-281 875.0
HKD2_k127_1582355_10 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001029 252.0
HKD2_k127_1582355_11 PFAM Patatin K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000001163 236.0
HKD2_k127_1582355_12 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000002292 215.0
HKD2_k127_1582355_13 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000003735 214.0
HKD2_k127_1582355_14 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000002293 208.0
HKD2_k127_1582355_15 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000003516 203.0
HKD2_k127_1582355_16 CYTH K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000738 194.0
HKD2_k127_1582355_17 PFAM Acetyltransferase (GNAT) family K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000001597 189.0
HKD2_k127_1582355_18 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000003201 188.0
HKD2_k127_1582355_19 Phosphatidylethanolamine-binding protein - - - 0.00000000000000000000000000000000000000000000441 173.0
HKD2_k127_1582355_2 Adenylate cyclase - - - 4.318e-232 736.0
HKD2_k127_1582355_20 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000000004851 165.0
HKD2_k127_1582355_21 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000003971 168.0
HKD2_k127_1582355_22 phosphoribosyltransferase K00760 - 2.4.2.8 0.000000000000000000000000000000000000000005436 160.0
HKD2_k127_1582355_23 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000005552 128.0
HKD2_k127_1582355_24 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0016740,GO:0016772,GO:0016780,GO:0044238,GO:0071704,GO:1901576 2.7.8.7 0.000000000000000000000001064 109.0
HKD2_k127_1582355_25 - - - - 0.00000000000000003362 84.0
HKD2_k127_1582355_26 Peptidoglycan-binding protein, CsiV - - - 0.0000000001966 73.0
HKD2_k127_1582355_27 Domain of unknown function (DUF4845) - - - 0.0000000007955 69.0
HKD2_k127_1582355_3 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 571.0
HKD2_k127_1582355_4 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 430.0
HKD2_k127_1582355_5 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000906 353.0
HKD2_k127_1582355_6 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 311.0
HKD2_k127_1582355_7 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 315.0
HKD2_k127_1582355_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000001736 271.0
HKD2_k127_1582355_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000145 263.0
HKD2_k127_1592839_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 516.0
HKD2_k127_1592839_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 311.0
HKD2_k127_1592839_2 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005726 286.0
HKD2_k127_1592839_3 MotA TolQ ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002106 244.0
HKD2_k127_1592839_4 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000007603 194.0
HKD2_k127_1592839_5 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000738 168.0
HKD2_k127_1592839_6 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000000837 132.0
HKD2_k127_1647983_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 1.203e-294 940.0
HKD2_k127_1647983_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 4.21e-233 728.0
HKD2_k127_1647983_10 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.00000000000000000000000000000000000000000002104 166.0
HKD2_k127_1647983_11 PFAM Peptidase M22, glycoprotease K14742 - - 0.00000000000000000000000000000000000001389 157.0
HKD2_k127_1647983_12 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000003071 91.0
HKD2_k127_1647983_13 TIGRFAM conserved repeat domain - - - 0.00000000000000004469 91.0
HKD2_k127_1647983_2 Helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 574.0
HKD2_k127_1647983_3 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 453.0
HKD2_k127_1647983_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 428.0
HKD2_k127_1647983_5 Belongs to the transferase hexapeptide repeat family K00674 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 422.0
HKD2_k127_1647983_6 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 405.0
HKD2_k127_1647983_7 Signal transduction histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005192 344.0
HKD2_k127_1647983_8 Two component response regulator for the phosphate regulon K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 301.0
HKD2_k127_1647983_9 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007686 270.0
HKD2_k127_1665266_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 527.0
HKD2_k127_1665266_1 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K10552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 514.0
HKD2_k127_1665266_10 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 323.0
HKD2_k127_1665266_11 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 315.0
HKD2_k127_1665266_12 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006986 291.0
HKD2_k127_1665266_13 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007211 260.0
HKD2_k127_1665266_14 peroxidase activity K00435 - - 0.000000000000000000000000000000000000000000000000000000000000000000001301 260.0
HKD2_k127_1665266_15 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000001719 199.0
HKD2_k127_1665266_16 Putative esterase - - - 0.00000000000000000000000000000000000000000000005289 171.0
HKD2_k127_1665266_17 phospholipase Carboxylesterase - - - 0.00000000000000000000000000000000000000000189 167.0
HKD2_k127_1665266_18 signal transduction histidine kinase - - - 0.000000000000000000000000000000000002274 155.0
HKD2_k127_1665266_19 phospholipase Carboxylesterase - - - 0.0000000000000000000000000000000001328 147.0
HKD2_k127_1665266_2 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 512.0
HKD2_k127_1665266_20 SnoaL-like domain - - - 0.00000000000000000000000000000002312 140.0
HKD2_k127_1665266_21 SnoaL-like domain - - - 0.00000000006032 74.0
HKD2_k127_1665266_3 Belongs to the binding-protein-dependent transport system permease family K10553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 463.0
HKD2_k127_1665266_4 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 446.0
HKD2_k127_1665266_5 PFAM ABC transporter related K10554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 420.0
HKD2_k127_1665266_6 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 400.0
HKD2_k127_1665266_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 362.0
HKD2_k127_1665266_8 Transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 342.0
HKD2_k127_1665266_9 electron transfer activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 349.0
HKD2_k127_1723088_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 1.081e-266 840.0
HKD2_k127_1723088_1 OmpA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 337.0
HKD2_k127_1723088_2 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005021 259.0
HKD2_k127_1723088_3 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000005591 196.0
HKD2_k127_1723088_4 Type VI secretion K07169,K11894,K11913 - - 0.00000000000000000000000000000000000000000007284 178.0
HKD2_k127_1723088_5 Domain of unknown function (DUF1820) - - - 0.00000000000000000000000000000000000000007279 155.0
HKD2_k127_174564_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 599.0
HKD2_k127_174564_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.000000000000000000000000000000000003396 142.0
HKD2_k127_183596_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 8.409e-222 707.0
HKD2_k127_183596_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 447.0
HKD2_k127_183596_10 - - - - 0.000000000000000000000000000000008644 136.0
HKD2_k127_183596_2 RHS Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008503 429.0
HKD2_k127_183596_3 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 424.0
HKD2_k127_183596_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 399.0
HKD2_k127_183596_5 PepSY-associated TM region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001006 295.0
HKD2_k127_183596_6 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001382 269.0
HKD2_k127_183596_7 Water Stress and Hypersensitive response - - - 0.00000000000000000000000000000000000000001658 175.0
HKD2_k127_183596_8 Protein of unknown function (DUF2721) - - - 0.00000000000000000000000000000000005567 140.0
HKD2_k127_183596_9 Putative phage abortive infection protein - - - 0.000000000000000000000000000000004759 139.0
HKD2_k127_1883245_0 Cytochrome c-type biogenesis protein CcmF K02198 - - 5.321e-220 707.0
HKD2_k127_1883245_1 Enoyl-CoA hydratase/isomerase - - - 2.036e-196 632.0
HKD2_k127_1883245_10 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 329.0
HKD2_k127_1883245_11 glycerophosphodiester phosphodiesterase activity K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 314.0
HKD2_k127_1883245_12 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001631 274.0
HKD2_k127_1883245_13 3-oxoacyl-(Acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000006416 256.0
HKD2_k127_1883245_14 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002122 257.0
HKD2_k127_1883245_15 PFAM Aminotransferase, class IV K02619 - 4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000004425 247.0
HKD2_k127_1883245_16 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000531 222.0
HKD2_k127_1883245_17 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000001006 206.0
HKD2_k127_1883245_18 TIGRFAM periplasmic protein K02199 - - 0.00000000000000000000000000000000000000000000000005848 185.0
HKD2_k127_1883245_19 Pilus assembly protein PilZ K02676 - - 0.00000000000000000000000000000000000000000000000302 177.0
HKD2_k127_1883245_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 584.0
HKD2_k127_1883245_20 COG0501 Zn-dependent protease with chaperone function - - - 0.00000000000000000000000000000000000000000000001864 180.0
HKD2_k127_1883245_21 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000001823 171.0
HKD2_k127_1883245_22 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657,K07664 - - 0.000000000000000000000000000000000000000000005792 172.0
HKD2_k127_1883245_23 Redoxin domain protein - - - 0.000000000000000000000000000000000000001655 153.0
HKD2_k127_1883245_24 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000001532 153.0
HKD2_k127_1883245_25 DNA polymerase III, delta' K02341 - 2.7.7.7 0.00000000000000000000000000000000001456 152.0
HKD2_k127_1883245_26 Cytochrome C biogenesis K02200 - - 0.000000000000000000000000000000000166 147.0
HKD2_k127_1883245_27 subunit of a heme lyase K02200,K04017 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - 0.00000000000000000000000000000714 131.0
HKD2_k127_1883245_28 Transcriptional regulator K21747 - - 0.000000000000000000000000000007415 130.0
HKD2_k127_1883245_29 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000004626 125.0
HKD2_k127_1883245_3 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 384.0
HKD2_k127_1883245_30 Spore Coat Protein U domain - - - 0.0000000000000000000000002136 111.0
HKD2_k127_1883245_31 Domain of unknown function (DUF4266) - - - 0.000000000000000000207 98.0
HKD2_k127_1883245_32 pilus organization K07346 - - 0.00000000000002091 82.0
HKD2_k127_1883245_33 Spore Coat Protein U domain - - - 0.00000000000005273 79.0
HKD2_k127_1883245_34 MTH538 TIR-like domain (DUF1863) - - - 0.0000000000007706 76.0
HKD2_k127_1883245_35 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000007325 71.0
HKD2_k127_1883245_36 AAA domain - - - 0.000001119 61.0
HKD2_k127_1883245_37 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors K12973 - 2.3.1.251 0.00000479 55.0
HKD2_k127_1883245_4 outer membrane usher protein K07347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 386.0
HKD2_k127_1883245_5 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 357.0
HKD2_k127_1883245_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008914 354.0
HKD2_k127_1883245_7 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 343.0
HKD2_k127_1883245_8 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 336.0
HKD2_k127_1883245_9 ApbE family K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 323.0
HKD2_k127_1886304_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 7.176e-264 823.0
HKD2_k127_1886304_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 343.0
HKD2_k127_1886304_2 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000005629 232.0
HKD2_k127_1933180_0 2 iron, 2 sulfur cluster binding - - - 0.0 1609.0
HKD2_k127_1933180_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1344.0
HKD2_k127_1933180_10 LemA family K03744 - - 0.00000000000000000000000000000000000367 155.0
HKD2_k127_1933180_11 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.0000000000000000000000006107 108.0
HKD2_k127_1933180_12 YCII-related domain - - - 0.000000000000000335 82.0
HKD2_k127_1933180_13 - - - - 0.0000000000001654 76.0
HKD2_k127_1933180_2 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing - - - 0.0 1103.0
HKD2_k127_1933180_3 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04099 - 1.13.11.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 536.0
HKD2_k127_1933180_4 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 540.0
HKD2_k127_1933180_5 Pyrogallol hydroxytransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 328.0
HKD2_k127_1933180_6 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 297.0
HKD2_k127_1933180_7 Acid phosphatase homologues K09474 - 3.1.3.2 0.0000000000000000000000000000000000000000000000000000000000007675 220.0
HKD2_k127_1933180_8 Belongs to the UPF0502 family K09915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000186 215.0
HKD2_k127_1933180_9 Cytochrome P460 - - - 0.00000000000000000000000000000000000000001179 167.0
HKD2_k127_19682_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18299 - - 0.0 1417.0
HKD2_k127_19682_1 M13 family peptidase K01415,K07386 - 3.4.24.71 6.433e-216 690.0
HKD2_k127_19682_10 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000002394 171.0
HKD2_k127_19682_11 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000005287 177.0
HKD2_k127_19682_12 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000115 115.0
HKD2_k127_19682_13 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000001072 83.0
HKD2_k127_19682_14 - - - - 0.000000001771 69.0
HKD2_k127_19682_15 decarboxylase K01607 - 4.1.1.44 0.000000004451 65.0
HKD2_k127_19682_2 ABC-2 type transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 400.0
HKD2_k127_19682_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18298,K19586 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 388.0
HKD2_k127_19682_4 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 350.0
HKD2_k127_19682_5 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 293.0
HKD2_k127_19682_6 Transcriptional regulator K18996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001264 274.0
HKD2_k127_19682_7 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000001942 198.0
HKD2_k127_19682_8 peptidase - - - 0.000000000000000000000000000000000000000000000000007015 193.0
HKD2_k127_19682_9 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000757 181.0
HKD2_k127_1991297_0 PQQ-like domain K00117 - 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 598.0
HKD2_k127_1991297_1 Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 521.0
HKD2_k127_1991297_10 - - - - 0.0000000002016 73.0
HKD2_k127_1991297_2 Phosphate-selective porin O and P - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 376.0
HKD2_k127_1991297_3 Carboxylesterase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 331.0
HKD2_k127_1991297_4 FAD linked K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001324 278.0
HKD2_k127_1991297_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001206 269.0
HKD2_k127_1991297_6 FMN-binding domain protein - - - 0.000000000000000000000000000000000000009842 160.0
HKD2_k127_1991297_7 - - - - 0.0000000000000000000000000000000000003104 159.0
HKD2_k127_1991297_8 - - - - 0.0000000000000000000000000000000000005923 144.0
HKD2_k127_1991297_9 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000001029 119.0
HKD2_k127_2147298_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1184.0
HKD2_k127_2147298_1 alcohol dehydrogenase K00114 - 1.1.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 527.0
HKD2_k127_2147298_2 Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 499.0
HKD2_k127_2147298_4 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 441.0
HKD2_k127_2147298_5 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 394.0
HKD2_k127_2147298_6 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 297.0
HKD2_k127_2147298_7 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K08738 - - 0.00000000000000000000000000000000000000000000000003569 185.0
HKD2_k127_2147298_8 histone acetyltransferase HPA2 and related acetyltransferases - GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - 0.000000000000000074 90.0
HKD2_k127_220636_0 Major facilitator superfamily K08218 - - 5.433e-195 616.0
HKD2_k127_220636_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 458.0
HKD2_k127_220636_10 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000004484 123.0
HKD2_k127_220636_11 Domain of unknown function (DUF4124) - - - 0.0000000000000000000001208 106.0
HKD2_k127_220636_12 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc K02913 - - 0.0000000000000000007781 86.0
HKD2_k127_220636_14 - - - - 0.00003418 56.0
HKD2_k127_220636_15 Diguanylate cyclase - - - 0.0001315 52.0
HKD2_k127_220636_2 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 457.0
HKD2_k127_220636_3 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 394.0
HKD2_k127_220636_4 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 329.0
HKD2_k127_220636_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 326.0
HKD2_k127_220636_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003992 276.0
HKD2_k127_220636_7 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000001417 249.0
HKD2_k127_220636_8 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001711 248.0
HKD2_k127_220636_9 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000004528 239.0
HKD2_k127_2223618_0 acetolactate synthase K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 3.146e-286 892.0
HKD2_k127_2223618_1 receptor - - - 9.564e-233 747.0
HKD2_k127_2223618_10 AAA-like domain - - - 0.00000000000000000000000000000000000000004828 176.0
HKD2_k127_2223618_2 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 2.762e-196 627.0
HKD2_k127_2223618_3 Aminotransferase class-III K00822,K00833 - 2.6.1.18,2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000749 550.0
HKD2_k127_2223618_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 533.0
HKD2_k127_2223618_5 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 456.0
HKD2_k127_2223618_6 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 450.0
HKD2_k127_2223618_7 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 422.0
HKD2_k127_2223618_8 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 336.0
HKD2_k127_2223618_9 acetolactate synthase, small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000181 170.0
HKD2_k127_2282775_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1444.0
HKD2_k127_2282775_1 Acetoacetyl-CoA synthase K01907 - 6.2.1.16 8.292e-260 822.0
HKD2_k127_2282775_10 Cbb3-type cytochrome oxidase cytochrome c subunit K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009663 254.0
HKD2_k127_2282775_11 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000006848 244.0
HKD2_k127_2282775_12 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000003547 231.0
HKD2_k127_2282775_13 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000000000001251 200.0
HKD2_k127_2282775_14 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.0000000000000000000000000000000000000000000008491 171.0
HKD2_k127_2282775_15 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.0000000000000000000000000000000000005187 148.0
HKD2_k127_2282775_16 Predicted membrane protein (DUF2339) - - - 0.00000000000000000002348 95.0
HKD2_k127_2282775_17 Yip1 domain - - - 0.00000000000000000009534 102.0
HKD2_k127_2282775_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 4.382e-222 698.0
HKD2_k127_2282775_3 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 6.964e-203 647.0
HKD2_k127_2282775_4 Belongs to the heme-copper respiratory oxidase family K00404 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 609.0
HKD2_k127_2282775_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 428.0
HKD2_k127_2282775_6 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 415.0
HKD2_k127_2282775_7 Acyl-CoA thioesterase K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 340.0
HKD2_k127_2282775_8 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 334.0
HKD2_k127_2282775_9 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 328.0
HKD2_k127_2367797_0 DNA topological change K03168 - 5.99.1.2 1.701e-200 652.0
HKD2_k127_2367797_1 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 338.0
HKD2_k127_2367797_2 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000004339 157.0
HKD2_k127_2367797_3 PFAM Ankyrin repeat K06867 - - 0.00000000000000000000000000001274 136.0
HKD2_k127_240593_0 AcrB/AcrD/AcrF family - - - 0.0 1272.0
HKD2_k127_240593_1 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 3.157e-264 829.0
HKD2_k127_240593_10 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001977 259.0
HKD2_k127_240593_11 Transcriptional regulatory protein, C terminal K07669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002803 247.0
HKD2_k127_240593_12 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003957 261.0
HKD2_k127_240593_13 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000003194 256.0
HKD2_k127_240593_14 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000009569 212.0
HKD2_k127_240593_15 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000004531 213.0
HKD2_k127_240593_16 response to abiotic stimulus K06867 - - 0.00000000000000000000000000000000000000000000000000007329 207.0
HKD2_k127_240593_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000009116 178.0
HKD2_k127_240593_18 Transporter Component K07112 - - 0.0000000000000000000000000000000000000000004283 171.0
HKD2_k127_240593_19 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000001005 178.0
HKD2_k127_240593_2 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K12141 - - 4.047e-243 758.0
HKD2_k127_240593_20 SnoaL-like domain - - - 0.00000000000000000000000000000000002543 146.0
HKD2_k127_240593_21 - - - - 0.0000000000000000000000000000000002803 143.0
HKD2_k127_240593_22 amidohydrolase - - - 0.0000000000000000000000000000766 131.0
HKD2_k127_240593_23 - - - - 0.00000000000000000001694 106.0
HKD2_k127_240593_24 copG family - - - 0.00000000000000001277 84.0
HKD2_k127_240593_25 - - - - 0.000000000000001207 88.0
HKD2_k127_240593_26 - K09004 - - 0.00000000000001832 83.0
HKD2_k127_240593_27 helix_turn_helix multiple antibiotic resistance protein - - - 0.000001025 56.0
HKD2_k127_240593_28 FtsX-like permease family K02004 - - 0.0009216 50.0
HKD2_k127_240593_3 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 548.0
HKD2_k127_240593_4 Carboxylesterase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 518.0
HKD2_k127_240593_5 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 434.0
HKD2_k127_240593_6 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 403.0
HKD2_k127_240593_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000965 348.0
HKD2_k127_240593_8 overlaps another CDS with the same product name K19713 - 1.8.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008939 342.0
HKD2_k127_240593_9 ATPases associated with a variety of cellular activities K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 313.0
HKD2_k127_2479429_0 ABC transporter - - - 5.542e-285 883.0
HKD2_k127_2479429_1 PFAM histone deacetylase superfamily K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 383.0
HKD2_k127_2479429_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 337.0
HKD2_k127_2479429_3 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 313.0
HKD2_k127_2479429_4 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002722 255.0
HKD2_k127_2519489_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 589.0
HKD2_k127_2519489_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 391.0
HKD2_k127_2519489_11 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000005419 80.0
HKD2_k127_2519489_12 Phospholipid methyltransferase - - - 0.00001702 55.0
HKD2_k127_2519489_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 308.0
HKD2_k127_2519489_3 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001507 266.0
HKD2_k127_2519489_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000002918 201.0
HKD2_k127_2519489_5 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K18030 - 1.17.2.1 0.000000000000000000000000000000000000001547 151.0
HKD2_k127_2519489_6 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000004175 143.0
HKD2_k127_2519489_7 - - - - 0.0000000000000000007607 100.0
HKD2_k127_2519489_8 Putative prokaryotic signal transducing protein - - - 0.0000000000000002991 83.0
HKD2_k127_2519489_9 Sterol-binding domain protein K03690 - - 0.00000000000001534 86.0
HKD2_k127_2560190_0 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005097 278.0
HKD2_k127_2560190_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000002538 242.0
HKD2_k127_2560190_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000307 226.0
HKD2_k127_2560190_3 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.000000000000000000000000000000000000000000000829 177.0
HKD2_k127_2571580_1 Belongs to the peptidase M16 family K07263 - - 9.256e-300 949.0
HKD2_k127_2571580_10 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 465.0
HKD2_k127_2571580_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009288 415.0
HKD2_k127_2571580_12 SMP-30/Gluconolaconase/LRE-like region K01053,K13735 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 427.0
HKD2_k127_2571580_13 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 402.0
HKD2_k127_2571580_14 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 403.0
HKD2_k127_2571580_15 PFAM Glycosyl transferase family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 376.0
HKD2_k127_2571580_16 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 366.0
HKD2_k127_2571580_17 Enoyl-CoA hydratase/isomerase K18383 - 4.1.2.41,4.2.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 328.0
HKD2_k127_2571580_19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 296.0
HKD2_k127_2571580_2 E1-E2 ATPase K01535 - 3.6.3.6 4.444e-290 912.0
HKD2_k127_2571580_20 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002309 280.0
HKD2_k127_2571580_21 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003162 266.0
HKD2_k127_2571580_22 PRMT5 arginine-N-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006759 262.0
HKD2_k127_2571580_23 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002022 268.0
HKD2_k127_2571580_24 YdjC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003271 267.0
HKD2_k127_2571580_25 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001581 261.0
HKD2_k127_2571580_26 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000004194 258.0
HKD2_k127_2571580_27 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000001298 229.0
HKD2_k127_2571580_28 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.0000000000000000000000000000000000000000000000000000003453 206.0
HKD2_k127_2571580_29 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000005619 175.0
HKD2_k127_2571580_3 COG4993 Glucose dehydrogenase - - - 2.708e-230 733.0
HKD2_k127_2571580_30 Transcription elongation factor, GreA/GreB, C-term - - - 0.00000000000000000000000000000000000002392 152.0
HKD2_k127_2571580_31 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000001723 150.0
HKD2_k127_2571580_32 Protein kinase domain - - - 0.000000000000000000000000000009789 136.0
HKD2_k127_2571580_33 carboxymuconolactone decarboxylase - - - 0.000000000000000000000000000638 127.0
HKD2_k127_2571580_34 Domain of unknown function (DUF4136) - - - 0.000000001158 67.0
HKD2_k127_2571580_35 GtrA-like protein - - - 0.0000001472 59.0
HKD2_k127_2571580_4 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 1.235e-228 734.0
HKD2_k127_2571580_5 PQQ enzyme repeat - - - 1.873e-220 704.0
HKD2_k127_2571580_6 Aldehyde dehydrogenase family - - - 6.243e-218 686.0
HKD2_k127_2571580_7 PQQ enzyme repeat - - - 5.363e-197 658.0
HKD2_k127_2571580_8 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 577.0
HKD2_k127_2571580_9 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 543.0
HKD2_k127_2591225_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 1.164e-230 720.0
HKD2_k127_2591225_1 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 614.0
HKD2_k127_2591225_10 Protein of unknown function (DUF3426) - - - 0.0000000000000001024 92.0
HKD2_k127_2591225_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 603.0
HKD2_k127_2591225_3 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 548.0
HKD2_k127_2591225_4 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 373.0
HKD2_k127_2591225_5 Ribosomal protein L11 methyltransferase K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000008026 244.0
HKD2_k127_2591225_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000003788 189.0
HKD2_k127_2591225_7 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000001448 175.0
HKD2_k127_2591225_8 Thioredoxin-like - - - 0.0000000000000000000000000001155 123.0
HKD2_k127_2591225_9 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 - - 0.0000000000000000001446 92.0
HKD2_k127_2654025_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1315.0
HKD2_k127_2654025_1 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 517.0
HKD2_k127_2654025_10 serine-type peptidase activity - - - 0.000000000000000000000000001291 113.0
HKD2_k127_2654025_11 transmembrane transporter activity K08195 - - 0.00000000000000000000000003923 114.0
HKD2_k127_2654025_2 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 429.0
HKD2_k127_2654025_3 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 403.0
HKD2_k127_2654025_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 375.0
HKD2_k127_2654025_6 Sugar (and other) transporter K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 360.0
HKD2_k127_2654025_7 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 342.0
HKD2_k127_2654025_8 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000007288 246.0
HKD2_k127_2654025_9 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000006127 192.0
HKD2_k127_2657208_0 multicopper oxidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009984 322.0
HKD2_k127_2657208_1 copper resistance K07233 - - 0.000000000000000000000000000000000000000000000000000000000000000000001606 246.0
HKD2_k127_2657208_2 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000002054 243.0
HKD2_k127_2657208_3 PFAM NnrU protein - - - 0.0000000000000000000000000000000000000000000000000004663 190.0
HKD2_k127_2657208_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000002539 141.0
HKD2_k127_2657208_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000004495 142.0
HKD2_k127_2657208_6 - - - - 0.0000000000000000000000001158 116.0
HKD2_k127_2657208_7 Protein of unknown function (DUF1090) - - - 0.0000000000000000000000002445 114.0
HKD2_k127_2657208_8 - - - - 0.00000000000000009118 91.0
HKD2_k127_2657208_9 - - - - 0.0003865 49.0
HKD2_k127_2664643_0 DNA topological change K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 591.0
HKD2_k127_2664643_1 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 426.0
HKD2_k127_2664643_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003493 267.0
HKD2_k127_2664643_3 Prolyl 4-hydroxylase alpha subunit homologues. K07336 - - 0.00000000000000000000000000000000000000000000000001042 188.0
HKD2_k127_2664643_5 Phage derived protein Gp49-like (DUF891) - - - 0.0000000000000007195 81.0
HKD2_k127_2675197_0 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 365.0
HKD2_k127_2675197_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 349.0
HKD2_k127_2675197_2 Beta-lactamase K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000457 272.0
HKD2_k127_2675197_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000001394 117.0
HKD2_k127_2675197_4 MmgE/PrpD family - - - 0.000000000000000000000001774 109.0
HKD2_k127_2684449_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1177.0
HKD2_k127_2684449_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 3.742e-270 841.0
HKD2_k127_2684449_10 DNA recombination protein RmuC K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 406.0
HKD2_k127_2684449_11 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 314.0
HKD2_k127_2684449_12 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 300.0
HKD2_k127_2684449_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 295.0
HKD2_k127_2684449_14 protein-(glutamine-N5) methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005758 294.0
HKD2_k127_2684449_15 reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007777 283.0
HKD2_k127_2684449_16 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000001038 261.0
HKD2_k127_2684449_17 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000003806 251.0
HKD2_k127_2684449_18 HAD-superfamily hydrolase, subfamily IA, variant 1 K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000331 199.0
HKD2_k127_2684449_19 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000003372 157.0
HKD2_k127_2684449_2 sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008006 529.0
HKD2_k127_2684449_20 - - - - 0.000000000000000000000000000000000000006356 149.0
HKD2_k127_2684449_21 PFAM RNA recognition motif - - - 0.000000000000000000000000000000009154 132.0
HKD2_k127_2684449_22 - - - - 0.00000000000000000000000000002241 129.0
HKD2_k127_2684449_23 TIGRFAM competence protein ComEA helix-hairpin-helix K02237 - - 0.00000000001919 75.0
HKD2_k127_2684449_24 Yip1 domain - - - 0.000000008146 65.0
HKD2_k127_2684449_25 SnoaL-like domain - - - 0.00000479 55.0
HKD2_k127_2684449_26 helix_turn_helix multiple antibiotic resistance protein - - - 0.00007964 54.0
HKD2_k127_2684449_27 Lipopolysaccharide assembly protein A domain K08992 - - 0.000146 48.0
HKD2_k127_2684449_28 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796,GO:1902495,GO:1990195,GO:1990196,GO:1990351 - 0.000215 44.0
HKD2_k127_2684449_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 511.0
HKD2_k127_2684449_4 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 500.0
HKD2_k127_2684449_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 470.0
HKD2_k127_2684449_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 444.0
HKD2_k127_2684449_7 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008687 442.0
HKD2_k127_2684449_8 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 430.0
HKD2_k127_2684449_9 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 403.0
HKD2_k127_2712664_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 9.933e-278 870.0
HKD2_k127_2712664_1 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.104e-237 758.0
HKD2_k127_2712664_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000005973 57.0
HKD2_k127_2712664_11 - - - - 0.0005676 52.0
HKD2_k127_2712664_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 1.367e-223 703.0
HKD2_k127_2712664_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 546.0
HKD2_k127_2712664_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 474.0
HKD2_k127_2712664_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000142 256.0
HKD2_k127_2712664_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000161 209.0
HKD2_k127_2712664_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000001695 170.0
HKD2_k127_2712664_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000001925 148.0
HKD2_k127_2712664_9 - - - - 0.000000000003508 73.0
HKD2_k127_2716078_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 1.486e-201 636.0
HKD2_k127_2716078_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 362.0
HKD2_k127_2716078_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 327.0
HKD2_k127_2716078_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07663 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 304.0
HKD2_k127_2716078_4 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001229 288.0
HKD2_k127_2716078_5 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001631 254.0
HKD2_k127_2716078_6 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004051 244.0
HKD2_k127_2716078_7 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000514 217.0
HKD2_k127_2716078_8 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.000000000000000000000000000000000000003567 153.0
HKD2_k127_2716078_9 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000009139 87.0
HKD2_k127_2719183_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1179.0
HKD2_k127_2719183_1 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007933 405.0
HKD2_k127_2719183_2 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 326.0
HKD2_k127_2719183_3 COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - 0.0000000000000000000009725 99.0
HKD2_k127_2789700_0 PUA-like domain K00958 - 2.7.7.4 1.177e-275 857.0
HKD2_k127_2789700_1 MFS/sugar transport protein K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 520.0
HKD2_k127_2789700_10 malonyl CoA-acyl carrier protein transacylase K00645,K13935 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 323.0
HKD2_k127_2789700_11 acetylesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 309.0
HKD2_k127_2789700_12 D-arabinono-1,4-lactone oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 296.0
HKD2_k127_2789700_13 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004241 267.0
HKD2_k127_2789700_14 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000005942 247.0
HKD2_k127_2789700_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000001883 234.0
HKD2_k127_2789700_16 protein conserved in bacteria K09958 - - 0.0000000000000000000000000000000000000000000000000000000000008676 218.0
HKD2_k127_2789700_17 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000005019 174.0
HKD2_k127_2789700_18 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000001126 183.0
HKD2_k127_2789700_19 Protein of unknown function (DUF2849) - - - 0.000000000004965 74.0
HKD2_k127_2789700_2 Sulfite reductase K00381 - 1.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000532 493.0
HKD2_k127_2789700_21 - - - - 0.00000000004201 71.0
HKD2_k127_2789700_3 phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 504.0
HKD2_k127_2789700_4 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 447.0
HKD2_k127_2789700_5 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 376.0
HKD2_k127_2789700_6 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 377.0
HKD2_k127_2789700_7 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 377.0
HKD2_k127_2789700_8 ADP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 368.0
HKD2_k127_2789700_9 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 368.0
HKD2_k127_279741_0 glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 323.0
HKD2_k127_279741_1 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002827 283.0
HKD2_k127_279741_2 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000006567 242.0
HKD2_k127_279741_3 chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000000000000000000000000002164 162.0
HKD2_k127_279741_5 NmrA-like family K19267 - 1.6.5.2 0.0000000815 54.0
HKD2_k127_279741_6 CAAX protease self-immunity - - - 0.0000001424 64.0
HKD2_k127_2801158_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0 1099.0
HKD2_k127_2801158_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 458.0
HKD2_k127_2801158_2 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 380.0
HKD2_k127_2801158_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 346.0
HKD2_k127_2801158_4 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 304.0
HKD2_k127_2801158_5 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 300.0
HKD2_k127_2801158_6 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 288.0
HKD2_k127_2801158_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000003614 173.0
HKD2_k127_2801158_8 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000001784 119.0
HKD2_k127_2811859_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 7.54e-283 892.0
HKD2_k127_2811859_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 2.393e-213 698.0
HKD2_k127_2811859_2 Bacterial Na+/H+ antiporter B (NhaB) K03314 GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - 2.845e-194 617.0
HKD2_k127_2811859_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 384.0
HKD2_k127_2811859_4 Universal stress protein - - - 0.0000000000000000000000002086 120.0
HKD2_k127_2811859_5 Protein of unknown function (DUF423) - - - 0.00006128 51.0
HKD2_k127_2838876_0 Dehydrogenase K00117 - 1.1.5.2 2.529e-278 871.0
HKD2_k127_2838876_1 Fungal trichothecene efflux pump (TRI12) - - - 2.688e-214 677.0
HKD2_k127_2838876_10 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000004614 101.0
HKD2_k127_2838876_11 - - - - 0.0000000000000000000009478 109.0
HKD2_k127_2838876_13 - - - - 0.0000000001076 70.0
HKD2_k127_2838876_14 Thioesterase domain - - - 0.00000002085 59.0
HKD2_k127_2838876_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 451.0
HKD2_k127_2838876_3 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 445.0
HKD2_k127_2838876_4 receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 356.0
HKD2_k127_2838876_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 334.0
HKD2_k127_2838876_6 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008329 252.0
HKD2_k127_2838876_7 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000001378 159.0
HKD2_k127_2838876_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000009851 121.0
HKD2_k127_2838876_9 - - - - 0.0000000000000000000000001083 122.0
HKD2_k127_2859868_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 1.311e-260 813.0
HKD2_k127_2859868_1 Bacterial protein of unknown function (DUF853) K06915 - - 7.15e-207 654.0
HKD2_k127_2859868_2 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000003932 192.0
HKD2_k127_2859868_3 DUF218 domain - - - 0.00000000000000000000000000000000000000000000002069 179.0
HKD2_k127_2859868_4 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000001373 163.0
HKD2_k127_2859868_5 SnoaL-like domain - - - 0.000000001591 65.0
HKD2_k127_2859868_6 calcium-dependent protein kinase K13412 GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004683,GO:0005488,GO:0005515,GO:0005516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0008152,GO:0009555,GO:0009628,GO:0009719,GO:0009725,GO:0009737,GO:0009738,GO:0009755,GO:0009931,GO:0009987,GO:0010033,GO:0010152,GO:0010857,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0021700,GO:0023052,GO:0032501,GO:0032502,GO:0032870,GO:0033993,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046777,GO:0048229,GO:0048518,GO:0048583,GO:0048584,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071215,GO:0071229,GO:0071310,GO:0071396,GO:0071495,GO:0071704,GO:0071944,GO:0080134,GO:0097305,GO:0097306,GO:0140096,GO:1901564,GO:1901700,GO:1901701,GO:1902584,GO:2000070 2.7.11.1 0.00002967 53.0
HKD2_k127_292181_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1566.0
HKD2_k127_292181_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 4.366e-305 946.0
HKD2_k127_292181_2 carbamoyl-phosphate synthetase glutamine chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006759 546.0
HKD2_k127_292181_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 517.0
HKD2_k127_292181_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 510.0
HKD2_k127_292181_5 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 288.0
HKD2_k127_292181_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002168 276.0
HKD2_k127_292181_7 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000008623 216.0
HKD2_k127_292181_8 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000001836 219.0
HKD2_k127_292181_9 PFAM Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000002871 101.0
HKD2_k127_294859_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.2e-322 996.0
HKD2_k127_294859_1 Peptidase S46 - - - 1.508e-298 932.0
HKD2_k127_294859_2 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000009749 211.0
HKD2_k127_294859_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000001006 180.0
HKD2_k127_294859_4 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000009867 146.0
HKD2_k127_294859_5 COG1194 A G-specific DNA glycosylase K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000004677 78.0
HKD2_k127_2989801_0 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 587.0
HKD2_k127_2989801_1 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000008355 251.0
HKD2_k127_2989801_2 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002002 243.0
HKD2_k127_2989801_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000005162 235.0
HKD2_k127_2989801_4 - - - - 0.000000000000000000000000000000000000000000002125 174.0
HKD2_k127_2989801_5 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000003274 153.0
HKD2_k127_2989801_6 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 - 2.8.1.7 0.000000000000000000000000000000005622 137.0
HKD2_k127_2989801_7 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000006395 119.0
HKD2_k127_2989801_8 SnoaL-like domain - - - 0.0000008301 60.0
HKD2_k127_300046_0 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 600.0
HKD2_k127_300046_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 503.0
HKD2_k127_300046_2 HflC and HflK could encode or regulate a protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 391.0
HKD2_k127_300046_3 prohibitin homologues K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 394.0
HKD2_k127_300046_4 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000351 237.0
HKD2_k127_300046_5 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000001176 221.0
HKD2_k127_300046_6 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000002526 185.0
HKD2_k127_300046_7 WLM domain K07043 - - 0.0000000000000000000000000000000000006963 147.0
HKD2_k127_300046_8 competence protein - - - 0.0000000722 64.0
HKD2_k127_302149_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 582.0
HKD2_k127_302149_1 DNA polymerase III, delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000001584 260.0
HKD2_k127_302149_10 Trm112p-like protein - - - 0.0000000000000000001551 91.0
HKD2_k127_302149_11 - - - - 0.00003317 47.0
HKD2_k127_302149_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000001471 248.0
HKD2_k127_302149_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000005434 247.0
HKD2_k127_302149_4 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000006423 199.0
HKD2_k127_302149_5 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000000000000000000105 173.0
HKD2_k127_302149_6 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000001114 171.0
HKD2_k127_302149_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000001734 134.0
HKD2_k127_302149_8 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000001493 117.0
HKD2_k127_302149_9 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.000000000000000000000000001323 119.0
HKD2_k127_3035823_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 421.0
HKD2_k127_3035823_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 367.0
HKD2_k127_3035823_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000001408 231.0
HKD2_k127_3035823_3 TIGRFAM iron-sulfur cluster assembly protein IscA K13628 - - 0.0000000000000000000000000000000000000000005489 159.0
HKD2_k127_3035823_4 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K15396 - 2.1.1.200 0.0000000000000000000000000000000000000000008463 162.0
HKD2_k127_3035823_5 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.000000000000000000000000000000000000000002222 177.0
HKD2_k127_3035823_6 Domain of unknown function (DUF4115) K15539 - - 0.000000000002489 71.0
HKD2_k127_3035823_7 NifU-like N terminal domain - - - 0.0000008417 56.0
HKD2_k127_303920_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1204.0
HKD2_k127_303920_1 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 514.0
HKD2_k127_303920_10 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001799 250.0
HKD2_k127_303920_11 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000001485 191.0
HKD2_k127_303920_12 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000149 181.0
HKD2_k127_303920_13 Permease YjgP YjgQ K11720 - - 0.00000000000000000000000000000000000000000003074 183.0
HKD2_k127_303920_14 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000002032 162.0
HKD2_k127_303920_15 COG2927 DNA polymerase III, chi subunit K02339 GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 0.00000000000000000000000000000000008275 138.0
HKD2_k127_303920_16 pfam rdd - - - 0.0000000000000000000000000000005887 127.0
HKD2_k127_303920_17 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000007831 81.0
HKD2_k127_303920_19 - - - - 0.0000214 53.0
HKD2_k127_303920_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 477.0
HKD2_k127_303920_3 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 465.0
HKD2_k127_303920_4 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 432.0
HKD2_k127_303920_5 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 368.0
HKD2_k127_303920_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 323.0
HKD2_k127_303920_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 291.0
HKD2_k127_303920_8 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001242 267.0
HKD2_k127_303920_9 Permease YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009534 261.0
HKD2_k127_305621_0 PFAM PrkA AAA K07180 - - 4.743e-302 941.0
HKD2_k127_305621_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 6.759e-281 874.0
HKD2_k127_305621_10 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000006017 249.0
HKD2_k127_305621_11 Two component transcriptional regulator, winged helix family K07662 - - 0.00000000000000000000000000000000000000000000000000000000000000001711 231.0
HKD2_k127_305621_12 Histidine kinase K02484,K07640,K07642 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000001825 241.0
HKD2_k127_305621_13 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000003078 190.0
HKD2_k127_305621_14 Belongs to the P(II) protein family K04751,K04752 - - 0.00000000000000000000000000000000000000000000000003901 187.0
HKD2_k127_305621_15 - - - - 0.000000000000000004603 98.0
HKD2_k127_305621_17 - - - - 0.0000006587 62.0
HKD2_k127_305621_2 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.597e-255 823.0
HKD2_k127_305621_3 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 552.0
HKD2_k127_305621_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 463.0
HKD2_k127_305621_5 Transcriptional regulator K06714,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 439.0
HKD2_k127_305621_6 DNA repair photolyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 400.0
HKD2_k127_305621_7 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 391.0
HKD2_k127_305621_8 Belongs to the UPF0229 family K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008552 375.0
HKD2_k127_305621_9 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000711 283.0
HKD2_k127_3100302_0 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 469.0
HKD2_k127_3100302_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 406.0
HKD2_k127_3100302_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 347.0
HKD2_k127_3100302_3 Binding-protein-dependent transport system inner membrane component K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 332.0
HKD2_k127_3100302_4 Copper resistance protein D K07245 - - 0.000000000000001326 88.0
HKD2_k127_3100302_5 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.000000000001703 69.0
HKD2_k127_3100302_6 CopC domain K07156 - - 0.000000005688 62.0
HKD2_k127_3136429_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.727e-234 732.0
HKD2_k127_3136429_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 609.0
HKD2_k127_3136429_2 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 527.0
HKD2_k127_3136429_3 Helix-turn-helix domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 303.0
HKD2_k127_3136429_4 Protein of unknown function (DUF1415) K09941 - - 0.00000000000000000000000000000000000000000000000000000000005222 211.0
HKD2_k127_3185267_0 ATPase, P-type K01531 - 3.6.3.2 0.0 1047.0
HKD2_k127_3185267_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.094e-248 781.0
HKD2_k127_3185267_10 heat shock protein DnaJ K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 342.0
HKD2_k127_3185267_11 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 336.0
HKD2_k127_3185267_12 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 330.0
HKD2_k127_3185267_13 Helix-hairpin-helix domain K04477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 310.0
HKD2_k127_3185267_14 Ferritin, Dps family protein K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008268 276.0
HKD2_k127_3185267_15 response to abiotic stimulus K06867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000717 256.0
HKD2_k127_3185267_16 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000001566 194.0
HKD2_k127_3185267_18 pterin-4-alpha-carbinolamine dehydratase K01724 GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 0.0000000000000000000000000000000000000000000001251 174.0
HKD2_k127_3185267_2 L-lactate permease K03303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 622.0
HKD2_k127_3185267_21 Cytochrome c - - - 0.00000000000000000000000000003786 122.0
HKD2_k127_3185267_22 Universal stress protein K14055 GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701 - 0.0000000000000000000000003507 119.0
HKD2_k127_3185267_23 MerR HTH family regulatory protein K18997 - - 0.0000000000000000005884 100.0
HKD2_k127_3185267_24 NMT1-like family - - - 0.00000000000000002782 83.0
HKD2_k127_3185267_25 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000001273 70.0
HKD2_k127_3185267_3 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 522.0
HKD2_k127_3185267_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 492.0
HKD2_k127_3185267_5 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 471.0
HKD2_k127_3185267_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 428.0
HKD2_k127_3185267_7 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 407.0
HKD2_k127_3185267_8 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 368.0
HKD2_k127_3185267_9 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008311 354.0
HKD2_k127_3195296_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 6.197e-240 753.0
HKD2_k127_3195296_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 397.0
HKD2_k127_3195296_2 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 364.0
HKD2_k127_3195296_3 glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009796 357.0
HKD2_k127_3195296_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000573 134.0
HKD2_k127_3195296_5 Ribonuclease 2-5A K01165 GO:0001959,GO:0002252,GO:0002376,GO:0002682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006139,GO:0006355,GO:0006357,GO:0006364,GO:0006396,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009966,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0010646,GO:0010827,GO:0010828,GO:0016070,GO:0016072,GO:0016310,GO:0016363,GO:0016787,GO:0016788,GO:0019219,GO:0019221,GO:0019222,GO:0019538,GO:0019843,GO:0022613,GO:0023051,GO:0023052,GO:0030154,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031974,GO:0031981,GO:0032502,GO:0032879,GO:0034097,GO:0034340,GO:0034399,GO:0034470,GO:0034641,GO:0034660,GO:0034762,GO:0034764,GO:0036211,GO:0042221,GO:0042254,GO:0042802,GO:0043021,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043487,GO:0043488,GO:0043900,GO:0043901,GO:0043903,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045069,GO:0045071,GO:0045087,GO:0045088,GO:0045444,GO:0045893,GO:0045935,GO:0045944,GO:0046324,GO:0046326,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048525,GO:0048583,GO:0048584,GO:0048869,GO:0050776,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0060255,GO:0060337,GO:0060338,GO:0060759,GO:0061013,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071345,GO:0071357,GO:0071704,GO:0071840,GO:0080090,GO:0080134,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0098542,GO:0140098,GO:1900076,GO:1900078,GO:1901360,GO:1901363,GO:1901564,GO:1902680,GO:1903311,GO:1903506,GO:1903508,GO:1903900,GO:1903901,GO:2000112,GO:2001141,GO:2001273,GO:2001275 - 0.00000000001257 74.0
HKD2_k127_3276955_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 8.45e-241 748.0
HKD2_k127_3276955_1 AcrB/AcrD/AcrF family K03296,K07788,K07789,K21133 - - 6.31e-232 744.0
HKD2_k127_3276955_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 8.326e-200 629.0
HKD2_k127_3276955_3 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 456.0
HKD2_k127_3276955_4 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005576 260.0
HKD2_k127_3276955_5 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001065 265.0
HKD2_k127_3276955_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000003219 250.0
HKD2_k127_3323384_0 efflux pump K18138,K18322 - - 0.0 1384.0
HKD2_k127_3323384_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 396.0
HKD2_k127_3323384_10 Protein of unknown function, DUF255 K01829 - 5.3.4.1 0.0000000000000000007535 100.0
HKD2_k127_3323384_11 - - - - 0.000001661 55.0
HKD2_k127_3323384_12 WD-40 repeat - - - 0.0004597 53.0
HKD2_k127_3323384_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 339.0
HKD2_k127_3323384_3 PFAM Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 306.0
HKD2_k127_3323384_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 294.0
HKD2_k127_3323384_5 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000182 259.0
HKD2_k127_3323384_6 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000001409 229.0
HKD2_k127_3323384_7 TIGRFAM histidinol-phosphate phosphatase HisN, inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.00000000000000000000000000000000000000000000303 179.0
HKD2_k127_3323384_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000007887 155.0
HKD2_k127_3323384_9 transcriptional - - - 0.0000000000000000000000000000003081 130.0
HKD2_k127_3344080_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1089.0
HKD2_k127_3344080_1 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 321.0
HKD2_k127_3344080_2 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006669 290.0
HKD2_k127_3344080_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000002211 258.0
HKD2_k127_3344080_4 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000001405 230.0
HKD2_k127_3344080_5 N-acetyl-gamma-glutamyl-phosphate reductase activity K00145 - 1.2.1.38 0.000000000031 66.0
HKD2_k127_3441332_0 TIGRFAM FeS assembly protein SufB K09014 - - 8.52e-270 835.0
HKD2_k127_3441332_1 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 343.0
HKD2_k127_3441332_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 336.0
HKD2_k127_3441332_3 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 318.0
HKD2_k127_3441332_4 Redoxin K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000000005114 199.0
HKD2_k127_3441332_5 PFAM Amino acid-binding ACT K03567 - - 0.00000000000000000000000000000000000000000000000000001048 197.0
HKD2_k127_3441332_6 transcriptional regulator - - - 0.0000000000000000000000000000000000211 140.0
HKD2_k127_3504905_0 Type II secretory pathway, component HofQ K02666 - - 4.399e-203 656.0
HKD2_k127_3504905_1 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 462.0
HKD2_k127_3504905_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 409.0
HKD2_k127_3504905_3 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 379.0
HKD2_k127_3504905_4 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 333.0
HKD2_k127_3504905_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000005536 214.0
HKD2_k127_3504905_6 Pilus assembly protein PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000107 207.0
HKD2_k127_3504905_7 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000001044 179.0
HKD2_k127_3504905_8 PFAM Fimbrial assembly K02663 - - 0.000000000000000000000000000000000000000000004906 171.0
HKD2_k127_3504905_9 pilus assembly protein pilp K02665 - - 0.00000000000000000000000000000000000000000005804 167.0
HKD2_k127_350670_0 DEAD/H associated K03724 - - 0.0 1262.0
HKD2_k127_350670_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.994e-249 785.0
HKD2_k127_350670_2 Pyruvate kinase K00873 - 2.7.1.40 3.922e-226 717.0
HKD2_k127_350670_3 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 558.0
HKD2_k127_350670_4 (ABC) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 358.0
HKD2_k127_350670_5 proteolysis - - - 0.000000000000000000000000000000000000000001431 168.0
HKD2_k127_350670_6 Protein of unknown function (DUF3775) - - - 0.00000000000000000000000001799 112.0
HKD2_k127_350670_7 - - - - 0.000000000000000007002 89.0
HKD2_k127_350670_8 - - - - 0.0000000002363 68.0
HKD2_k127_3565166_0 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 6.435e-291 899.0
HKD2_k127_3565166_1 COG4993 Glucose dehydrogenase - - - 1.025e-214 691.0
HKD2_k127_3565166_10 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001048 268.0
HKD2_k127_3565166_11 (Lipo)protein K04754 - - 0.000000000000000000000000000000000000000000000000001358 192.0
HKD2_k127_3565166_12 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000003751 186.0
HKD2_k127_3565166_13 - - - - 0.00000000000000000000000000000000000000000000000005786 193.0
HKD2_k127_3565166_14 methyltransferase - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000009571 177.0
HKD2_k127_3565166_15 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000005869 183.0
HKD2_k127_3565166_16 PQQ-like domain K00117 - 1.1.5.2 0.00000000000000000000000000000000000000000006163 164.0
HKD2_k127_3565166_17 MlaD protein K02067 - - 0.0000000000000000000000000000000000000007789 153.0
HKD2_k127_3565166_18 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.0000000000000000000000000000000000003416 154.0
HKD2_k127_3565166_19 - - - - 0.000000000000000000002614 108.0
HKD2_k127_3565166_2 Dehydrogenase K00114 - 1.1.2.8 1.098e-202 647.0
HKD2_k127_3565166_20 - - - - 0.00000000000000001927 96.0
HKD2_k127_3565166_22 Planctomycete cytochrome C - - - 0.00000000000003938 76.0
HKD2_k127_3565166_23 - - - - 0.00000000006451 74.0
HKD2_k127_3565166_24 - - - - 0.00000002145 68.0
HKD2_k127_3565166_25 NTP binding protein (Contains STAS domain) K07122 - - 0.0000003124 58.0
HKD2_k127_3565166_26 glycoside hydrolase family 38 K01191 - 3.2.1.24 0.000001136 62.0
HKD2_k127_3565166_27 OmpA family - - - 0.00005465 55.0
HKD2_k127_3565166_3 metal-dependent hydrolase of the TIM-barrel fold K03392,K10220 - 4.1.1.45,4.2.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 527.0
HKD2_k127_3565166_4 PQQ-like domain K05889 - 1.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 491.0
HKD2_k127_3565166_5 (ABC) transporter K02065 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 332.0
HKD2_k127_3565166_6 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 309.0
HKD2_k127_3565166_7 Methylenetetrahydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 302.0
HKD2_k127_3565166_8 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 312.0
HKD2_k127_3565166_9 N-acetyltransferase K00675 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000000000000000000000000002333 275.0
HKD2_k127_357162_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 614.0
HKD2_k127_357162_1 acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000008767 103.0
HKD2_k127_3797618_0 TonB-dependent receptor plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 544.0
HKD2_k127_3797618_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 407.0
HKD2_k127_3797618_2 Major facilitator K05819,K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000886 403.0
HKD2_k127_3797618_3 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 306.0
HKD2_k127_3797618_4 nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000003737 194.0
HKD2_k127_3797618_5 Choline kinase - - - 0.00000000000000004284 95.0
HKD2_k127_3797618_6 YKOF-related Family - - - 0.00000000001283 68.0
HKD2_k127_3827905_0 PQQ enzyme repeat K00117 - 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 301.0
HKD2_k127_3827905_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001441 256.0
HKD2_k127_3827905_2 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000002792 142.0
HKD2_k127_3827905_3 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000000000000000000003513 138.0
HKD2_k127_3827905_4 thiolester hydrolase activity K06889 - - 0.000000000008187 78.0
HKD2_k127_3827905_5 - K01992 - - 0.00000007101 63.0
HKD2_k127_3901694_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 593.0
HKD2_k127_3901694_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007729 500.0
HKD2_k127_3901694_2 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 331.0
HKD2_k127_3901694_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.0000000000000000000000000000000000009586 142.0
HKD2_k127_3901694_4 Preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000000000003844 123.0
HKD2_k127_3901694_5 PIN domain - - - 0.00000002879 63.0
HKD2_k127_3901694_6 SpoVT / AbrB like domain - - - 0.0002309 48.0
HKD2_k127_3912233_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.467e-284 891.0
HKD2_k127_3912233_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 2.09e-206 648.0
HKD2_k127_3912233_10 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 355.0
HKD2_k127_3912233_11 abc transporter atp-binding protein K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 340.0
HKD2_k127_3912233_12 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 327.0
HKD2_k127_3912233_13 Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS K06958 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 300.0
HKD2_k127_3912233_14 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000904 252.0
HKD2_k127_3912233_15 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000002079 230.0
HKD2_k127_3912233_16 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000000000000000000000000000000000000000000000000001272 221.0
HKD2_k127_3912233_17 TraB family K09973 - - 0.0000000000000000000000000000000000000000000000001394 196.0
HKD2_k127_3912233_18 peptidase S16, lon K07157 - - 0.0000000000000000000000000000000000000001137 168.0
HKD2_k127_3912233_19 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000000000000007126 154.0
HKD2_k127_3912233_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 590.0
HKD2_k127_3912233_20 COG1544 Ribosome-associated protein Y (PSrp-1) K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000135 143.0
HKD2_k127_3912233_21 Rubredoxin - - - 0.00000000000000000000004543 100.0
HKD2_k127_3912233_22 Belongs to the BolA IbaG family - - - 0.000000000000000000003973 95.0
HKD2_k127_3912233_23 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA K11719 - - 0.00000000000007947 79.0
HKD2_k127_3912233_24 - - - - 0.0000002744 60.0
HKD2_k127_3912233_3 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 566.0
HKD2_k127_3912233_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 531.0
HKD2_k127_3912233_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 526.0
HKD2_k127_3912233_6 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 497.0
HKD2_k127_3912233_7 Sugar (and other) transporter K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 450.0
HKD2_k127_3912233_8 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 422.0
HKD2_k127_3912233_9 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 385.0
HKD2_k127_3912406_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 511.0
HKD2_k127_3912406_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 430.0
HKD2_k127_3912406_2 Major Facilitator Superfamily K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 329.0
HKD2_k127_3912406_3 TIGRFAM 3'(2'),5'-bisphosphate nucleotidase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 295.0
HKD2_k127_3912406_4 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000584 267.0
HKD2_k127_3912406_5 Hydrolase K20881 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000002638 247.0
HKD2_k127_3912406_6 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000003291 167.0
HKD2_k127_3912406_7 small protein containing a coiled-coil domain - - - 0.000000000000057 74.0
HKD2_k127_3914247_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 565.0
HKD2_k127_3914247_1 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 442.0
HKD2_k127_3914247_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004703 316.0
HKD2_k127_3914247_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000262 169.0
HKD2_k127_3914247_4 HDOD domain - - - 0.0000000000000000000000000000000000000000002627 169.0
HKD2_k127_3914247_5 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000172 83.0
HKD2_k127_3919511_0 ABC transporter K06147,K06148 - - 3.3e-246 777.0
HKD2_k127_3919511_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 7.514e-246 792.0
HKD2_k127_3919511_2 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 1.414e-205 660.0
HKD2_k127_3919511_3 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 329.0
HKD2_k127_3919511_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 301.0
HKD2_k127_3919511_5 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 317.0
HKD2_k127_3919511_6 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 287.0
HKD2_k127_3919511_7 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000005853 229.0
HKD2_k127_3919511_8 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000001422 123.0
HKD2_k127_3923971_0 Bacterial protein of unknown function (DUF885) - - - 2.934e-227 719.0
HKD2_k127_3923971_1 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 1.266e-222 706.0
HKD2_k127_3923971_2 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008839 432.0
HKD2_k127_3923971_3 Putative vitamin uptake transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 358.0
HKD2_k127_3923971_4 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 318.0
HKD2_k127_3923971_5 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000002978 210.0
HKD2_k127_3923971_6 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000004192 190.0
HKD2_k127_3923971_7 Aldehyde dehydrogenase family K13922,K18119 - 1.2.1.76,1.2.1.87 0.00000000000000000000000000000003483 126.0
HKD2_k127_3956673_0 PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 616.0
HKD2_k127_3956673_1 DNA topological change K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 498.0
HKD2_k127_3956673_2 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 391.0
HKD2_k127_3956673_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 373.0
HKD2_k127_3956673_4 Biotin-lipoyl like K01993 - - 0.000000000000000000000000000000000000000128 165.0
HKD2_k127_3956673_5 - - - - 0.00000000000000000000000000000000007116 154.0
HKD2_k127_3956673_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000002946 122.0
HKD2_k127_3956673_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.0003959 49.0
HKD2_k127_3963305_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000671 497.0
HKD2_k127_3963305_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 422.0
HKD2_k127_3963305_10 belongs to the histidinol- phosphatase family K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000001156 124.0
HKD2_k127_3963305_11 protein, YerC YecD - - - 0.00000000000000000000000001007 112.0
HKD2_k127_3963305_12 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.00000000000000000001275 103.0
HKD2_k127_3963305_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 370.0
HKD2_k127_3963305_3 Histidine biosynthesis bifunctional protein HisB K01089 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 322.0
HKD2_k127_3963305_4 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 323.0
HKD2_k127_3963305_5 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 308.0
HKD2_k127_3963305_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000007816 243.0
HKD2_k127_3963305_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000001325 231.0
HKD2_k127_3963305_8 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000004051 226.0
HKD2_k127_3963305_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000006875 123.0
HKD2_k127_3972647_0 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006376 425.0
HKD2_k127_3972647_1 Psort location Cytoplasmic, score 8.96 K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 370.0
HKD2_k127_3972647_2 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 359.0
HKD2_k127_3972647_3 methyltransferase K10218 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 318.0
HKD2_k127_3975266_0 PFAM glycoside hydrolase 15-related K01178 - 3.2.1.3 6.678e-301 951.0
HKD2_k127_3975266_1 arylsulfatase activity K01083,K01126 - 3.1.3.8,3.1.4.46 1.472e-198 641.0
HKD2_k127_3975266_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 599.0
HKD2_k127_3975266_3 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005232 273.0
HKD2_k127_3975266_4 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000765 258.0
HKD2_k127_3975266_5 universal stress protein - - - 0.0000000000000000000000000000000000000866 146.0
HKD2_k127_4016648_0 GTP-binding protein TypA K06207 - - 1.985e-286 894.0
HKD2_k127_4016648_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 1.213e-225 711.0
HKD2_k127_4016648_10 peptidylprolyl isomerase, FKBP-type K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000006608 244.0
HKD2_k127_4016648_11 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000001433 221.0
HKD2_k127_4016648_12 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000001277 211.0
HKD2_k127_4016648_13 Protein of unknown function (DUF3014) - - - 0.000000000000000000000000000000000000000000000000007745 199.0
HKD2_k127_4016648_14 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.000000000000000000000000000000000000000001778 173.0
HKD2_k127_4016648_16 - - - - 0.00000000000000000000001377 111.0
HKD2_k127_4016648_17 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000008167 81.0
HKD2_k127_4016648_18 SnoaL-like domain - - - 0.0000000000007809 81.0
HKD2_k127_4016648_19 Sh3 type 3 domain protein - - - 0.00000000000234 73.0
HKD2_k127_4016648_2 SMART Elongator protein 3 MiaB NifB - - - 8.349e-225 708.0
HKD2_k127_4016648_20 - - - - 0.000000000003732 73.0
HKD2_k127_4016648_21 Glycine-zipper domain - - - 0.0000000000239 74.0
HKD2_k127_4016648_3 methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 1.218e-221 697.0
HKD2_k127_4016648_4 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 555.0
HKD2_k127_4016648_5 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 347.0
HKD2_k127_4016648_6 dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009663 295.0
HKD2_k127_4016648_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001035 276.0
HKD2_k127_4016648_8 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004613 287.0
HKD2_k127_4016648_9 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001758 246.0
HKD2_k127_4031123_0 FAD linked oxidases, C-terminal domain K18930 - - 3.7e-312 972.0
HKD2_k127_4031123_1 - - - - 1.832e-292 918.0
HKD2_k127_4031123_10 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 364.0
HKD2_k127_4031123_11 Carboxypeptidase regulatory-like domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 342.0
HKD2_k127_4031123_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 322.0
HKD2_k127_4031123_13 Membrane-associated sensor, integral membrane domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 307.0
HKD2_k127_4031123_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001239 282.0
HKD2_k127_4031123_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007542 304.0
HKD2_k127_4031123_16 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001095 253.0
HKD2_k127_4031123_17 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000003762 222.0
HKD2_k127_4031123_18 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000008704 194.0
HKD2_k127_4031123_19 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000001159 197.0
HKD2_k127_4031123_2 Belongs to the ABC transporter superfamily K02031,K02032 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 6.202e-281 903.0
HKD2_k127_4031123_20 sister chromatid segregation - - - 0.0000000000000000000000000000000000000000000000407 187.0
HKD2_k127_4031123_21 - - - - 0.00000000000000000000000000000000000000000000009663 185.0
HKD2_k127_4031123_22 Planctomycete cytochrome C - - - 0.000000000000000000000000000000000000000000003446 171.0
HKD2_k127_4031123_23 DNA-templated transcription, initiation K03088,K03091 - - 0.00000000000000000000000000000000000000003342 159.0
HKD2_k127_4031123_24 cellulase activity - - - 0.00000000000000000000000000000000000001837 157.0
HKD2_k127_4031123_25 - - - - 0.000000000000000000000000000001382 126.0
HKD2_k127_4031123_26 - - - - 0.0000000000000000000000000009515 118.0
HKD2_k127_4031123_27 - - - - 0.000000000000000000000000003214 121.0
HKD2_k127_4031123_28 - - - - 0.00000000000000001461 94.0
HKD2_k127_4031123_3 Peptidase family M49 K01277 - 3.4.14.4 9.954e-243 771.0
HKD2_k127_4031123_30 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000006693 64.0
HKD2_k127_4031123_31 COG4235 Cytochrome c biogenesis factor K02200 - - 0.00006577 52.0
HKD2_k127_4031123_4 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 559.0
HKD2_k127_4031123_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 548.0
HKD2_k127_4031123_6 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 525.0
HKD2_k127_4031123_7 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 526.0
HKD2_k127_4031123_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 381.0
HKD2_k127_4031123_9 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 373.0
HKD2_k127_4055756_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.921e-218 687.0
HKD2_k127_4055756_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 338.0
HKD2_k127_4055756_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 326.0
HKD2_k127_4055756_3 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000000000000000000000000006459 243.0
HKD2_k127_4055756_4 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000005998 236.0
HKD2_k127_4055756_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000002748 186.0
HKD2_k127_4055756_6 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000004155 156.0
HKD2_k127_4055756_7 Colicin v production K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.000000000000000000000000000695 119.0
HKD2_k127_4055756_8 Sporulation related domain K03749 - - 0.000000002477 67.0
HKD2_k127_4059255_0 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 483.0
HKD2_k127_4059255_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 356.0
HKD2_k127_4059255_2 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000006534 132.0
HKD2_k127_4077128_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 493.0
HKD2_k127_4077128_1 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 318.0
HKD2_k127_4077128_10 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000151 65.0
HKD2_k127_4077128_11 cellulase activity - - - 0.000004303 58.0
HKD2_k127_4077128_12 - - - - 0.00007964 54.0
HKD2_k127_4077128_2 PFAM SMP-30 Gluconolaconase LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000000000000000002859 168.0
HKD2_k127_4077128_3 - - - - 0.0000000000000000000000000000000008828 148.0
HKD2_k127_4077128_4 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000001014 132.0
HKD2_k127_4077128_5 GtrA-like protein - - - 0.0000000000000000000005034 102.0
HKD2_k127_4077128_6 - - - - 0.000000000000000000451 92.0
HKD2_k127_4077128_7 - - - - 0.0000000000000003788 89.0
HKD2_k127_4077128_8 Integrin alpha (beta-propellor repeats). - - - 0.00000000000005313 75.0
HKD2_k127_4077128_9 - - - - 0.00000000003006 75.0
HKD2_k127_4085531_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 2.158e-210 661.0
HKD2_k127_4085531_1 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 467.0
HKD2_k127_4085531_10 Protein involved in meta-pathway of phenol degradation - - - 0.00000000002331 74.0
HKD2_k127_4085531_11 - - - - 0.0000000000858 68.0
HKD2_k127_4085531_12 - - - - 0.0004832 49.0
HKD2_k127_4085531_2 ABC transporter K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
HKD2_k127_4085531_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002053 254.0
HKD2_k127_4085531_4 ABC 3 transport family K09819,K11606,K11708,K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000001957 248.0
HKD2_k127_4085531_5 COG2030 Acyl dehydratase - - - 0.0000000000000000000000000000000000000000000000000005298 192.0
HKD2_k127_4085531_6 - - - - 0.00000000000000000000001617 104.0
HKD2_k127_4085531_7 - - - - 0.0000000000000000000008912 109.0
HKD2_k127_4085531_8 Protein of unknown function (DUF1161) - - - 0.0000000000000000004198 89.0
HKD2_k127_4085531_9 - - - - 0.00000000001784 75.0
HKD2_k127_4097118_0 DNA helicase - - - 2.693e-307 983.0
HKD2_k127_4097118_1 permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004127 272.0
HKD2_k127_4097118_10 - - - - 0.0000000005318 65.0
HKD2_k127_4097118_11 - - - - 0.0000003016 61.0
HKD2_k127_4097118_2 Cellulose biosynthesis protein BcsQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001067 253.0
HKD2_k127_4097118_3 Fe-S-cluster oxidoreductase K06940 - - 0.0000000000000000000000000000000000000000001191 164.0
HKD2_k127_4097118_4 MazG-like family - - - 0.000000000000000000000000000000000000003802 154.0
HKD2_k127_4097118_5 CHAD domain containing protein - - - 0.000000000000000000000000000000007572 142.0
HKD2_k127_4097118_6 - - - - 0.0000000000000000000000000000001143 135.0
HKD2_k127_4097118_7 Protein of unknown function (DUF3667) - - - 0.0000000000000000000418 101.0
HKD2_k127_4097118_8 NHL repeat - - - 0.0000000000000005133 91.0
HKD2_k127_4097118_9 Outer Membrane Lipoprotein - - - 0.00000000000107 75.0
HKD2_k127_4103314_0 TonB dependent receptor K02014 - - 1.086e-313 979.0
HKD2_k127_4103314_1 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 4.843e-299 936.0
HKD2_k127_4103314_10 sulfate ABC transporter K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 372.0
HKD2_k127_4103314_11 TIGRFAM sulfate ABC transporter, inner membrane subunit CysT K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009577 335.0
HKD2_k127_4103314_12 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002461 256.0
HKD2_k127_4103314_13 KDP operon transcriptional regulatory protein KdpE K07667 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
HKD2_k127_4103314_14 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000001007 235.0
HKD2_k127_4103314_15 OsmC-like protein K04063 - - 0.0000000000000000000000000000000000000000001295 168.0
HKD2_k127_4103314_16 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.0000000000000000000000005109 105.0
HKD2_k127_4103314_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 4.122e-290 908.0
HKD2_k127_4103314_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.503e-264 828.0
HKD2_k127_4103314_4 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 5.081e-223 721.0
HKD2_k127_4103314_5 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 603.0
HKD2_k127_4103314_6 Magnesium transport protein CorA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 567.0
HKD2_k127_4103314_7 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 485.0
HKD2_k127_4103314_8 Bacterial extracellular solute-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 429.0
HKD2_k127_4103314_9 ATPase activity K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000916 425.0
HKD2_k127_4135444_0 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 341.0
HKD2_k127_4135444_1 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 306.0
HKD2_k127_4135444_2 ABC-3 protein K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000983 280.0
HKD2_k127_4151898_0 Bacterial virulence protein (VirJ) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 592.0
HKD2_k127_4151898_1 receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 457.0
HKD2_k127_4151898_2 Aspartyl asparaginyl beta-hydroxylase and related dioxygenases K12979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 357.0
HKD2_k127_4151898_3 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000388 125.0
HKD2_k127_417869_0 PQQ-like domain K05889 - 1.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 585.0
HKD2_k127_417869_1 Acetyl-coenzyme A synthetase N-terminus K01895,K01908 GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224 6.2.1.1,6.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 543.0
HKD2_k127_417869_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000003946 102.0
HKD2_k127_417869_11 secretion ATPase, PEP-CTERM locus subfamily K02450 - - 0.00000000000000001762 97.0
HKD2_k127_417869_12 - - - - 0.0000000000000001244 91.0
HKD2_k127_417869_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.000005466 51.0
HKD2_k127_417869_2 FAD binding domain K00480,K22270 - 1.14.13.1,1.14.13.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 416.0
HKD2_k127_417869_3 COG3264 Small-conductance mechanosensitive channel K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 333.0
HKD2_k127_417869_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005612 259.0
HKD2_k127_417869_5 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002246 246.0
HKD2_k127_417869_6 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000006666 240.0
HKD2_k127_417869_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001856 237.0
HKD2_k127_417869_8 - - - - 0.000000000000000000000000002132 124.0
HKD2_k127_4265116_0 Major Facilitator Superfamily - - - 7.242e-257 804.0
HKD2_k127_4265116_1 PFAM Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 379.0
HKD2_k127_4265116_2 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000004601 264.0
HKD2_k127_4265116_3 - - - - 0.000000000000000000000000000000000000000000000008291 189.0
HKD2_k127_4265116_4 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000004938 63.0
HKD2_k127_4269109_0 Major Facilitator Superfamily - - - 2.142e-207 665.0
HKD2_k127_4269109_1 Dehydrogenase K00114 - 1.1.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 611.0
HKD2_k127_4269109_10 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000001167 239.0
HKD2_k127_4269109_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000001855 231.0
HKD2_k127_4269109_12 - - - - 0.00000000000000000000000000000000000000000000000000000001199 214.0
HKD2_k127_4269109_13 - - - - 0.0000000000000000000000000000000000000000000000000000522 196.0
HKD2_k127_4269109_14 - - - - 0.00000000000000000000000000000000000000000000146 168.0
HKD2_k127_4269109_15 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000000000000000000002088 164.0
HKD2_k127_4269109_16 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000004341 162.0
HKD2_k127_4269109_17 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.00000000000000000000000000000000000007849 146.0
HKD2_k127_4269109_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000212 143.0
HKD2_k127_4269109_19 cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.000000000000000000000000000000001357 147.0
HKD2_k127_4269109_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 569.0
HKD2_k127_4269109_20 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000003367 119.0
HKD2_k127_4269109_21 YceI-like domain - - - 0.000000000000000000000002145 111.0
HKD2_k127_4269109_22 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000002253 115.0
HKD2_k127_4269109_23 Domain of unknown function (DUF4279) - - - 0.00004862 52.0
HKD2_k127_4269109_3 PQQ-like domain K00117 - 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 416.0
HKD2_k127_4269109_4 glucose sorbosone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 400.0
HKD2_k127_4269109_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 393.0
HKD2_k127_4269109_6 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 323.0
HKD2_k127_4269109_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001621 278.0
HKD2_k127_4269109_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000287 275.0
HKD2_k127_4269109_9 Protein of unknown function (DUF938) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001248 248.0
HKD2_k127_430531_0 Tannase and feruloyl esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 415.0
HKD2_k127_430531_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 411.0
HKD2_k127_430531_2 Prolyl oligopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 385.0
HKD2_k127_430531_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007463 265.0
HKD2_k127_430531_4 - - - - 0.00000000000000000000000000000000000000009182 158.0
HKD2_k127_4381033_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 4.317e-196 629.0
HKD2_k127_4381033_1 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 353.0
HKD2_k127_4381033_2 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000978 309.0
HKD2_k127_4381033_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000002335 203.0
HKD2_k127_4381033_4 cytochrome - - - 0.000000000000000000000000000000000000000001584 164.0
HKD2_k127_4381033_5 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000001609 161.0
HKD2_k127_4381033_6 COG3312 F0F1-type ATP synthase, subunit I K02116 - - 0.000001671 55.0
HKD2_k127_4446785_0 Peptidase dimerisation domain - - - 9.529e-198 627.0
HKD2_k127_4446785_1 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 598.0
HKD2_k127_4446785_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 310.0
HKD2_k127_4446785_3 Conserved Protein - - - 0.000000000000000000000000000000000000000000000000000000000004623 213.0
HKD2_k127_4446785_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000001674 190.0
HKD2_k127_4446785_5 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000003335 184.0
HKD2_k127_4446785_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000001111 175.0
HKD2_k127_4446785_7 FR47-like protein - - - 0.00000001698 66.0
HKD2_k127_4446785_8 - - - - 0.0000405 53.0
HKD2_k127_448207_0 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 7.046e-201 631.0
HKD2_k127_448207_1 PFAM glycine cleavage T protein (aminomethyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 614.0
HKD2_k127_448207_2 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 550.0
HKD2_k127_448207_3 PFAM Tannase and feruloyl esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 332.0
HKD2_k127_448207_4 short chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002458 259.0
HKD2_k127_448207_5 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000002716 172.0
HKD2_k127_448207_6 Gluconate 2-dehydrogenase subunit 3 K06152 - 1.1.99.3 0.0000000000000000000000000000000002367 142.0
HKD2_k127_448207_7 Putative regulatory protein - - - 0.0000006007 57.0
HKD2_k127_448207_8 WD domain, G-beta repeat - - - 0.00005986 55.0
HKD2_k127_4495203_0 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 9.824e-275 864.0
HKD2_k127_4495203_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 628.0
HKD2_k127_4495203_2 - - - - 0.000000000000000003133 88.0
HKD2_k127_4506324_0 Thermolysin metallopeptidase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 419.0
HKD2_k127_4506324_1 aspartyl asparaginyl beta-hydroxylase K12979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 354.0
HKD2_k127_4506324_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000681 217.0
HKD2_k127_4506324_3 - - - - 0.00000000000000000000000000000000000000000000002111 180.0
HKD2_k127_4506324_4 (twin-arginine translocation) pathway signal - - - 0.000000000000000002107 91.0
HKD2_k127_4506324_5 - - - - 0.000000000000000003073 94.0
HKD2_k127_4506324_6 - - - - 0.000000000001178 71.0
HKD2_k127_4677262_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 345.0
HKD2_k127_4677262_2 NMT1-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 350.0
HKD2_k127_4677262_3 Surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000003439 249.0
HKD2_k127_4717546_0 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 608.0
HKD2_k127_4717546_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000006313 203.0
HKD2_k127_4717546_2 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000000001 117.0
HKD2_k127_4717546_3 - - - - 0.000000000000000000004396 107.0
HKD2_k127_4717546_4 - - - - 0.00000000001455 70.0
HKD2_k127_4717546_5 Evidence 4 Homologs of previously reported genes of - - - 0.0000000001011 66.0
HKD2_k127_4717877_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.647e-266 831.0
HKD2_k127_4717877_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.029e-199 634.0
HKD2_k127_4717877_10 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 0.00000000000000006444 85.0
HKD2_k127_4717877_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 584.0
HKD2_k127_4717877_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 505.0
HKD2_k127_4717877_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006639 348.0
HKD2_k127_4717877_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000003384 254.0
HKD2_k127_4717877_6 peptidase K06194 - - 0.0000000000000000000000000000000000000000000000000006747 193.0
HKD2_k127_4717877_7 Belongs to the GcvT family K06980 - - 0.000000000000000000009368 94.0
HKD2_k127_4717877_8 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000272 98.0
HKD2_k127_4717877_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000001955 86.0
HKD2_k127_4738838_0 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 468.0
HKD2_k127_4738838_1 Aspartate tyrosine aromatic aminotransferase K00813,K00832 - 2.6.1.1,2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 436.0
HKD2_k127_4738838_3 NADPH:quinone reductase activity K00344 GO:0000166,GO:0003674,GO:0003824,GO:0003960,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0010941,GO:0016491,GO:0016651,GO:0016655,GO:0019362,GO:0019637,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0051186,GO:0055086,GO:0055114,GO:0065007,GO:0070402,GO:0071704,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 373.0
HKD2_k127_4738838_4 phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001222 245.0
HKD2_k127_4738838_5 regulation of cobalamin metabolic process K11390 GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0008150,GO:0009987,GO:0016043,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019222,GO:0022607,GO:0030656,GO:0031323,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046912,GO:0047777,GO:0050789,GO:0050794,GO:0051171,GO:0051193,GO:0051259,GO:0051260,GO:0062012,GO:0065003,GO:0065007,GO:0070206,GO:0070207,GO:0071840,GO:0106064,GO:1901401 - 0.000000000000000000000000000000000000000000000000000000000000000000000176 252.0
HKD2_k127_4738838_7 - - - - 0.0000000000000002569 85.0
HKD2_k127_4777035_0 Metallopeptidase family M24 - - - 3.312e-197 624.0
HKD2_k127_4777035_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 449.0
HKD2_k127_4777035_2 response to abiotic stimulus K06867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007216 262.0
HKD2_k127_4797439_0 Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 541.0
HKD2_k127_4797439_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 539.0
HKD2_k127_4797439_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008737 269.0
HKD2_k127_4797439_11 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007989 243.0
HKD2_k127_4797439_12 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000001047 222.0
HKD2_k127_4797439_13 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000001579 215.0
HKD2_k127_4797439_14 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000000000000000000000007457 188.0
HKD2_k127_4797439_15 - - - - 0.0000000000000000000000000000000000000001139 166.0
HKD2_k127_4797439_16 Metal-sensitive transcriptional repressor K07807 - - 0.000000000000000000000000000000000000002586 147.0
HKD2_k127_4797439_17 ABC-type antimicrobial peptide transport system, permease component - - - 0.000000000000000000000000000000000001347 147.0
HKD2_k127_4797439_18 - - - - 0.00000000000000000000000004456 112.0
HKD2_k127_4797439_19 - - - - 0.0000000000000000000000004179 108.0
HKD2_k127_4797439_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 495.0
HKD2_k127_4797439_20 - - - - 0.000000000000006535 85.0
HKD2_k127_4797439_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 434.0
HKD2_k127_4797439_4 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 366.0
HKD2_k127_4797439_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 342.0
HKD2_k127_4797439_6 Cytochrome C biogenesis protein transmembrane region K08970 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 347.0
HKD2_k127_4797439_7 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 326.0
HKD2_k127_4797439_8 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 314.0
HKD2_k127_4797439_9 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 314.0
HKD2_k127_480274_0 negative regulation of hippo signaling - - - 1.027e-230 746.0
HKD2_k127_480274_1 Protein of unknown function, DUF255 K06888 - - 3.641e-225 717.0
HKD2_k127_480274_10 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000005421 229.0
HKD2_k127_480274_11 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000471 226.0
HKD2_k127_480274_12 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000003241 220.0
HKD2_k127_480274_13 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.0000000000000000000000000000000000000000000000000000000002529 212.0
HKD2_k127_480274_14 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000001925 206.0
HKD2_k127_480274_15 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001348 199.0
HKD2_k127_480274_16 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000000003707 149.0
HKD2_k127_480274_17 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000000000000002902 127.0
HKD2_k127_480274_18 - K07283 - - 0.000000000000000000000000006754 121.0
HKD2_k127_480274_19 - - - - 0.00000000000000000000000003022 113.0
HKD2_k127_480274_2 aminopeptidase K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 555.0
HKD2_k127_480274_20 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - 0.00000000000000000000003438 101.0
HKD2_k127_480274_21 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000002515 101.0
HKD2_k127_480274_22 Belongs to the UPF0149 family K09895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000008032 94.0
HKD2_k127_480274_23 - - - - 0.0000000000000001748 80.0
HKD2_k127_480274_24 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000001265 78.0
HKD2_k127_480274_25 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.00000000009534 65.0
HKD2_k127_480274_26 TIGRFAM TIGR02449 family protein K09892 - - 0.0000000000967 65.0
HKD2_k127_480274_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 440.0
HKD2_k127_480274_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 333.0
HKD2_k127_480274_5 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 347.0
HKD2_k127_480274_6 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K18800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 315.0
HKD2_k127_480274_7 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001283 277.0
HKD2_k127_480274_8 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001925 262.0
HKD2_k127_480274_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000001435 227.0
HKD2_k127_4848959_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 3.139e-249 782.0
HKD2_k127_4848959_1 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 544.0
HKD2_k127_4848959_10 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.0000000000000000000000000000009195 132.0
HKD2_k127_4848959_11 - - - - 0.00000000000000000000000000008331 121.0
HKD2_k127_4848959_12 PFAM amidohydrolase - - - 0.000000000000000000004285 106.0
HKD2_k127_4848959_13 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00003471 55.0
HKD2_k127_4848959_14 Domain of unknown function (DUF4404) - - - 0.00004105 55.0
HKD2_k127_4848959_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 428.0
HKD2_k127_4848959_4 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001377 276.0
HKD2_k127_4848959_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.0000000000000000000000000000000000000000000000000000001835 209.0
HKD2_k127_4848959_7 Protein of unknown function (DUF1097) - - - 0.00000000000000000000000000000000000000000000002102 178.0
HKD2_k127_4848959_8 - - - - 0.000000000000000000000000000000000000000001837 164.0
HKD2_k127_4848959_9 DoxX-like family - - - 0.00000000000000000000000000000000000009204 154.0
HKD2_k127_4870885_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004557 281.0
HKD2_k127_4870885_1 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000001883 239.0
HKD2_k127_4870885_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000001359 199.0
HKD2_k127_4870885_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000009954 159.0
HKD2_k127_4870885_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000001075 123.0
HKD2_k127_4880192_0 Signal peptidase, peptidase S26 - - - 0.000000000000000000000000000000000000000000000000000000000000000005927 231.0
HKD2_k127_4880192_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000231 226.0
HKD2_k127_4880192_2 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000003172 229.0
HKD2_k127_4880192_3 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000000000001176 180.0
HKD2_k127_4880192_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000002036 101.0
HKD2_k127_4880192_5 Pfam:DUF461 K09796 - - 0.000000000000000000004339 100.0
HKD2_k127_4880192_6 Polymer-forming cytoskeletal - - - 0.000000000181 74.0
HKD2_k127_4880192_7 NlpE C-terminal OB domain K06079 - - 0.00000007401 64.0
HKD2_k127_4880192_8 pathogenesis - - - 0.000001826 60.0
HKD2_k127_4880270_0 Peptidase M16 - - - 0.0 1056.0
HKD2_k127_4880270_1 dihydroorotase K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 502.0
HKD2_k127_4880270_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 456.0
HKD2_k127_4880270_3 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000864 388.0
HKD2_k127_4880270_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 304.0
HKD2_k127_4880270_5 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001648 259.0
HKD2_k127_4946072_0 Aminomethyltransferase folate-binding domain - - - 3.008e-259 806.0
HKD2_k127_4946072_1 Belongs to the GcvT family K15066 - 2.1.1.341 4.191e-258 805.0
HKD2_k127_4946072_10 Glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000029 203.0
HKD2_k127_4946072_11 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000008005 197.0
HKD2_k127_4946072_12 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000004877 192.0
HKD2_k127_4946072_13 - - - - 0.00000000000000000000000000000000000000000003162 175.0
HKD2_k127_4946072_14 PFAM Sulfate transporter antisigma-factor antagonist STAS K17762 - - 0.00000000000000000000000000000000000001326 149.0
HKD2_k127_4946072_15 Stage II sporulation protein E K05518 - 3.1.3.3 0.00000000000000000000000000000000006988 146.0
HKD2_k127_4946072_16 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000005073 135.0
HKD2_k127_4946072_17 Histidine kinase-like ATPase domain K17752 - 2.7.11.1 0.00000000000000000000000000008624 121.0
HKD2_k127_4946072_18 - - - - 0.0000000000000000000000002159 117.0
HKD2_k127_4946072_19 - - - - 0.00000000000000000000006319 106.0
HKD2_k127_4946072_2 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 5.001e-242 764.0
HKD2_k127_4946072_20 - - - - 0.000000000000000000002623 104.0
HKD2_k127_4946072_21 - - - - 0.00000000000000001702 89.0
HKD2_k127_4946072_22 - - - - 0.00000000005572 69.0
HKD2_k127_4946072_3 Periplasmic glucan biosynthesis protein, MdoG K03670 - - 3.364e-211 672.0
HKD2_k127_4946072_4 Pyrrolo-quinoline quinone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 604.0
HKD2_k127_4946072_5 DNA topological change - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 546.0
HKD2_k127_4946072_6 Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) K17763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 415.0
HKD2_k127_4946072_7 Protein of unknown function (DUF1552) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 355.0
HKD2_k127_4946072_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000003853 241.0
HKD2_k127_4946072_9 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000142 234.0
HKD2_k127_5021295_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 425.0
HKD2_k127_5021295_1 recombinase XerD K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 386.0
HKD2_k127_5021295_2 Membrane protein TerC, possibly involved in tellurium resistance - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 307.0
HKD2_k127_5021295_3 carbonate dehydratase activity K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002877 287.0
HKD2_k127_5021295_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000000004003 216.0
HKD2_k127_5021295_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000622 186.0
HKD2_k127_5021295_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000001431 132.0
HKD2_k127_5021295_7 DoxX K15977 - - 0.000000000000000000000002249 112.0
HKD2_k127_5021295_8 PDZ domain - - - 0.0000000000000007474 89.0
HKD2_k127_5115563_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000741 501.0
HKD2_k127_5115563_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006246 467.0
HKD2_k127_5115563_2 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000006828 257.0
HKD2_k127_5115563_3 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000009276 221.0
HKD2_k127_5115563_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000003785 202.0
HKD2_k127_5115563_5 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - 0.000000000000000001422 101.0
HKD2_k127_5162713_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 5.639e-316 1015.0
HKD2_k127_5162713_1 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 558.0
HKD2_k127_5162713_10 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000002686 250.0
HKD2_k127_5162713_11 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000000000000000000000000000000000000009562 198.0
HKD2_k127_5162713_14 membrane protein domain - - - 0.0000000000000000000000000000000000000000000000002113 185.0
HKD2_k127_5162713_15 Diguanylate cyclase, GGDEF domain - - - 0.00000000000000000000000000000000000000000001215 178.0
HKD2_k127_5162713_16 histone H4-K16 acetylation K07020 - - 0.000000000000000000000000000000000000000007004 175.0
HKD2_k127_5162713_17 FtsX-like permease family K02004 - - 0.000000000000000000000000000000005166 135.0
HKD2_k127_5162713_18 - - - - 0.0000000000000000000000000000007873 126.0
HKD2_k127_5162713_19 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000254 124.0
HKD2_k127_5162713_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 484.0
HKD2_k127_5162713_20 - - - - 0.00000000000001643 85.0
HKD2_k127_5162713_21 - - - - 0.00000000000009793 76.0
HKD2_k127_5162713_22 Adenylate cyclase - - - 0.000000000000159 74.0
HKD2_k127_5162713_23 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000006975 58.0
HKD2_k127_5162713_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 495.0
HKD2_k127_5162713_4 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 345.0
HKD2_k127_5162713_5 Retinal pigment epithelial membrane protein K11159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 334.0
HKD2_k127_5162713_6 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 294.0
HKD2_k127_5162713_7 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000003019 265.0
HKD2_k127_5162713_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008839 254.0
HKD2_k127_5162713_9 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000008475 241.0
HKD2_k127_5169705_0 Pyridine nucleotide-disulphide oxidoreductase K00362,K05297 - 1.18.1.1,1.7.1.15 0.0 1274.0
HKD2_k127_5169705_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0 1074.0
HKD2_k127_5169705_10 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000853 185.0
HKD2_k127_5169705_11 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000006467 190.0
HKD2_k127_5169705_12 Rieske-like [2Fe-2S] domain K00363 - 1.7.1.15 0.000000000000000000000000000000000000004176 154.0
HKD2_k127_5169705_13 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.00000000000000000000000000000004597 131.0
HKD2_k127_5169705_14 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000001967 123.0
HKD2_k127_5169705_16 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.00000000000000006226 87.0
HKD2_k127_5169705_17 - - - - 0.0000001331 55.0
HKD2_k127_5169705_18 alcohol dehydrogenase - - - 0.0005693 43.0
HKD2_k127_5169705_2 ABC transporter K02049,K15555,K15578 - - 7.089e-232 734.0
HKD2_k127_5169705_3 NMT1-like family K15576 - - 7.083e-222 698.0
HKD2_k127_5169705_4 Tfp pilus assembly protein FimV - - - 2.289e-194 616.0
HKD2_k127_5169705_5 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050,K15577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 443.0
HKD2_k127_5169705_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005996 392.0
HKD2_k127_5169705_7 Glutathione S-Transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 326.0
HKD2_k127_5169705_8 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15576,K22067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 316.0
HKD2_k127_5169705_9 response regulator receiver K07183 - - 0.0000000000000000000000000000000000000000000000000000000000000000000058 243.0
HKD2_k127_5174595_0 secondary active sulfate transmembrane transporter activity K03321 - - 1.06e-265 857.0
HKD2_k127_5174595_1 Elongator protein 3, MiaB family, Radical SAM - - - 3.027e-242 765.0
HKD2_k127_5174595_10 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000008487 136.0
HKD2_k127_5174595_11 Endoribonuclease L-PSP - - - 0.0000000000000000000000552 104.0
HKD2_k127_5174595_12 COG0188 Type IIA topoisomerase (DNA gyrase topo II, topoisomerase IV), A subunit - - - 0.000000000000001012 79.0
HKD2_k127_5174595_13 OmpA-like transmembrane domain K03286 - - 0.000000006671 66.0
HKD2_k127_5174595_2 Sodium/hydrogen exchanger family K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 642.0
HKD2_k127_5174595_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 501.0
HKD2_k127_5174595_4 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 456.0
HKD2_k127_5174595_5 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005116 273.0
HKD2_k127_5174595_6 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001292 266.0
HKD2_k127_5174595_7 - - - - 0.000000000000000000000000000000000000000000001432 190.0
HKD2_k127_5174595_8 Asp Glu hydantoin racemase K01799,K06033 - 4.1.1.76,5.2.1.1 0.000000000000000000000000000000000000001955 158.0
HKD2_k127_5174595_9 Protein involved in receptor activity and transport K02014 - - 0.00000000000000000000000000000000000001219 150.0
HKD2_k127_5174767_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1064.0
HKD2_k127_5174767_1 PFAM peptidase M3A and M3B, thimet oligopeptidase F K01414 - 3.4.24.70 1.81e-231 735.0
HKD2_k127_5174767_10 Belongs to the Smg family K03747 - - 0.000000000000000000000000000000000000000000001587 169.0
HKD2_k127_5174767_11 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000005752 132.0
HKD2_k127_5174767_12 - - - - 0.000000000000000000003224 105.0
HKD2_k127_5174767_2 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 551.0
HKD2_k127_5174767_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 508.0
HKD2_k127_5174767_4 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 336.0
HKD2_k127_5174767_5 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 322.0
HKD2_k127_5174767_6 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004941 296.0
HKD2_k127_5174767_7 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009747 284.0
HKD2_k127_5174767_8 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001142 273.0
HKD2_k127_5174767_9 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000007232 194.0
HKD2_k127_5186396_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002166 259.0
HKD2_k127_5186396_1 - - - - 0.00000000000000000000000000000000000000000000000001439 191.0
HKD2_k127_5186396_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000007754 151.0
HKD2_k127_5186396_3 - - - - 0.000000000000000000000000000006607 135.0
HKD2_k127_5186396_4 - - - - 0.00000000000000000001759 101.0
HKD2_k127_5196442_0 Belongs to the IlvD Edd family - - - 1.986e-205 676.0
HKD2_k127_5196442_1 Tetratricopeptide repeat - - - 1.336e-203 652.0
HKD2_k127_5196442_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 575.0
HKD2_k127_5196442_3 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001327 268.0
HKD2_k127_5196442_4 - - - - 0.00000000000000000000000000000000000000000000004732 176.0
HKD2_k127_5196442_5 Sh3 type 3 domain protein K01361 - 3.4.21.96 0.00000000000000000000000000000000000000003896 160.0
HKD2_k127_5196442_6 arsenate reductase K00537 - 1.20.4.1 0.0000000000000000000000000000000000001002 144.0
HKD2_k127_5196442_7 - - - - 0.000000002808 66.0
HKD2_k127_5196442_8 - - - - 0.000001259 60.0
HKD2_k127_5196442_9 COG0457 FOG TPR repeat - - - 0.000006251 51.0
HKD2_k127_5203018_0 MacB-like periplasmic core domain - - - 1.295e-211 690.0
HKD2_k127_5203018_1 acyl-CoA dehydrogenase K00252 - 1.3.8.6 5.112e-204 647.0
HKD2_k127_5203018_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005529 246.0
HKD2_k127_5203018_3 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000001433 195.0
HKD2_k127_5203018_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000001204 147.0
HKD2_k127_5203018_5 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000005336 100.0
HKD2_k127_5211901_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1236.0
HKD2_k127_5211901_1 Belongs to the ClpA ClpB family K03694 - - 0.0 1037.0
HKD2_k127_5211901_10 Type II secretion system protein C - - - 0.00000002877 61.0
HKD2_k127_5211901_2 DNA segregation ATPase FtsK SpoIIIE K03466 - - 2.839e-273 860.0
HKD2_k127_5211901_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 550.0
HKD2_k127_5211901_4 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 404.0
HKD2_k127_5211901_5 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009554 279.0
HKD2_k127_5211901_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000000000000000000000000000007297 165.0
HKD2_k127_5211901_7 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000002246 154.0
HKD2_k127_5211901_8 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000101 136.0
HKD2_k127_5211901_9 PFAM VanZ - - - 0.000000000004779 71.0
HKD2_k127_5248674_0 Flavin containing amine oxidoreductase - - - 1.97e-212 678.0
HKD2_k127_5248674_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 350.0
HKD2_k127_5248674_2 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 295.0
HKD2_k127_5248674_3 SnoaL-like domain K06893 - - 0.0000000000000000000000000000000005555 138.0
HKD2_k127_5248674_4 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000003365 121.0
HKD2_k127_5248674_6 - - - - 0.00007437 47.0
HKD2_k127_5277262_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 606.0
HKD2_k127_5277262_1 Trypsin K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 291.0
HKD2_k127_5277262_2 Stringent starvation protein A K03599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003862 261.0
HKD2_k127_5277262_3 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002065 273.0
HKD2_k127_5277262_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000002221 246.0
HKD2_k127_5277262_5 stringent starvation protein b K03600 - - 0.0000000000000000000000000000000001126 142.0
HKD2_k127_5277262_6 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000002743 99.0
HKD2_k127_5320962_0 TonB dependent receptor - - - 4.19e-217 694.0
HKD2_k127_5320962_1 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 608.0
HKD2_k127_5320962_10 Glycosyl transferases group 1 - - - 0.0000000000000000000000006563 114.0
HKD2_k127_5320962_11 - - - - 0.00000000000000000000004737 110.0
HKD2_k127_5320962_12 - - - - 0.0000000000000000002299 98.0
HKD2_k127_5320962_13 - - - - 0.00000000000000002659 88.0
HKD2_k127_5320962_2 Uncharacterised MFS-type transporter YbfB K05548,K05819,K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 456.0
HKD2_k127_5320962_3 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 434.0
HKD2_k127_5320962_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000008712 188.0
HKD2_k127_5320962_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K03825 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.000000000000000000000000000000000000000000000000002316 189.0
HKD2_k127_5320962_6 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000002603 184.0
HKD2_k127_5320962_7 MatE K03327 - - 0.00000000000000000000000000000004947 130.0
HKD2_k127_5320962_8 - - - - 0.000000000000000000000000000002638 128.0
HKD2_k127_5320962_9 - - - - 0.000000000000000000000000321 111.0
HKD2_k127_538146_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 411.0
HKD2_k127_538146_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 354.0
HKD2_k127_538146_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000004588 233.0
HKD2_k127_538146_3 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000003392 194.0
HKD2_k127_538146_4 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000000000002421 124.0
HKD2_k127_538146_5 PFAM YicC-like - - - 0.0000000000000000000000000000003929 140.0
HKD2_k127_5408394_0 xanthine dehydrogenase activity - - - 0.0 1049.0
HKD2_k127_5408394_1 DNA topological change - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 553.0
HKD2_k127_5408394_2 Protein of unknown function (DUF1552) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 308.0
HKD2_k127_5408394_3 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000002279 256.0
HKD2_k127_5408394_4 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000232 268.0
HKD2_k127_5408394_5 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000003372 194.0
HKD2_k127_5408394_6 FR47-like protein K06976 - - 0.0000000000000000000000000000000000001196 153.0
HKD2_k127_5408394_7 retrograde transport, endosome to plasma membrane K21440 - - 0.0000000000000000000000000000008376 141.0
HKD2_k127_5409103_0 TonB-dependent receptor plug K02014 - - 7.444e-228 727.0
HKD2_k127_5409103_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.426e-224 713.0
HKD2_k127_5409103_2 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 450.0
HKD2_k127_5409103_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 297.0
HKD2_k127_5409103_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 305.0
HKD2_k127_5409103_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000001374 221.0
HKD2_k127_5479638_0 AlkA N-terminal domain K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 474.0
HKD2_k127_5479638_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 426.0
HKD2_k127_5479638_2 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 420.0
HKD2_k127_5479638_3 Transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 332.0
HKD2_k127_5479638_4 TIGRFAM anion transporter K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 341.0
HKD2_k127_5479638_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 306.0
HKD2_k127_5479638_6 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000001608 217.0
HKD2_k127_5479638_7 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000014 173.0
HKD2_k127_5479638_8 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000494 151.0
HKD2_k127_5479638_9 SnoaL-like domain - - - 0.00006446 52.0
HKD2_k127_551741_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - 6.211e-299 942.0
HKD2_k127_551741_1 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 461.0
HKD2_k127_551741_2 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000005626 160.0
HKD2_k127_5523950_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 2.908e-212 670.0
HKD2_k127_5523950_1 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 496.0
HKD2_k127_5523950_10 Protein of unknown function (DUF2845) - - - 0.00000001123 64.0
HKD2_k127_5523950_11 ABC-type uncharacterized transport system - - - 0.00006612 46.0
HKD2_k127_5523950_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 424.0
HKD2_k127_5523950_3 NADPH quinone K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 391.0
HKD2_k127_5523950_4 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 326.0
HKD2_k127_5523950_5 - - - - 0.0000000000000000000000000000000000000000000001086 175.0
HKD2_k127_5523950_6 Domain of unknown function (DUF4340) - - - 0.000000000000000000000000000000000000000000001057 181.0
HKD2_k127_5523950_7 - - - - 0.0000000000000000000000000000000000933 141.0
HKD2_k127_5523950_8 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000005478 103.0
HKD2_k127_5523950_9 PAS fold - - - 0.00000000000000000001845 102.0
HKD2_k127_5525505_0 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 1.246e-236 758.0
HKD2_k127_5525505_1 PFAM NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002178 256.0
HKD2_k127_5525505_10 - - - - 0.0000000004403 70.0
HKD2_k127_5525505_11 - - - - 0.000000007248 62.0
HKD2_k127_5525505_2 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004414 258.0
HKD2_k127_5525505_3 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004604 259.0
HKD2_k127_5525505_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000001228 241.0
HKD2_k127_5525505_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000003158 216.0
HKD2_k127_5525505_6 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000001332 207.0
HKD2_k127_5525505_7 - - - - 0.0000000000000000000000000000001423 129.0
HKD2_k127_5525505_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000006607 117.0
HKD2_k127_5525505_9 RQC K03654 GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 0.000000000001993 73.0
HKD2_k127_5566851_0 DNA helicase K03654 - 3.6.4.12 5.064e-238 749.0
HKD2_k127_5566851_1 PQQ-like domain K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 565.0
HKD2_k127_5566851_2 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000005997 233.0
HKD2_k127_5566851_3 protein conserved in bacteria K09966 - - 0.0000000000000000000000000000000000000000000000000000000000273 208.0
HKD2_k127_5566851_4 Dehydrogenase K00117 - 1.1.5.2 0.00000000000000000000000000000000000000004677 155.0
HKD2_k127_5566851_5 - - - - 0.000000000000000000000000000000000000004068 160.0
HKD2_k127_5566851_6 - - - - 0.000000000000000000000000000000009511 140.0
HKD2_k127_5566851_7 - - - - 0.0000000000000009008 88.0
HKD2_k127_5566851_8 - - - - 0.000000002553 63.0
HKD2_k127_5590390_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006523 552.0
HKD2_k127_5590390_1 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 503.0
HKD2_k127_5590390_2 SPFH Band 7 PHB domain protein - - - 0.000000000000000000000000000000000000000000000009302 183.0
HKD2_k127_5612707_0 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 423.0
HKD2_k127_5612707_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 414.0
HKD2_k127_5612707_2 major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 398.0
HKD2_k127_5612707_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001874 273.0
HKD2_k127_5612707_4 PQQ enzyme repeat - - - 0.0000000000000000000000000000000000000000491 158.0
HKD2_k127_5612707_5 - - - - 0.0000000000000000000000000000000000000002835 158.0
HKD2_k127_5612707_7 Pkd domain containing protein K01337 - 3.4.21.50 0.000000000000000000000000000004952 140.0
HKD2_k127_5612707_8 - - - - 0.000008388 56.0
HKD2_k127_5624285_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 3.286e-267 837.0
HKD2_k127_5624285_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 392.0
HKD2_k127_5624285_2 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 361.0
HKD2_k127_5624285_3 Transporter K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 293.0
HKD2_k127_5624285_4 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000004914 108.0
HKD2_k127_5696812_0 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 535.0
HKD2_k127_5696812_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 441.0
HKD2_k127_5696812_10 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000002427 203.0
HKD2_k127_5696812_11 S1/P1 Nuclease - - - 0.0000000000000000000000000000000000000000009682 169.0
HKD2_k127_5696812_12 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000000792 174.0
HKD2_k127_5696812_13 S1/P1 Nuclease - - - 0.0000000000000000000000000000000001445 151.0
HKD2_k127_5696812_14 PFAM WD40-like beta Propeller - - - 0.000000000002901 80.0
HKD2_k127_5696812_15 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000001292 68.0
HKD2_k127_5696812_2 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 424.0
HKD2_k127_5696812_3 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 426.0
HKD2_k127_5696812_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 376.0
HKD2_k127_5696812_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 287.0
HKD2_k127_5696812_6 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000008296 262.0
HKD2_k127_5696812_7 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003956 254.0
HKD2_k127_5696812_8 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000009572 238.0
HKD2_k127_5696812_9 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000001605 207.0
HKD2_k127_5706897_0 DNA topological change K03168 - 5.99.1.2 4.334e-200 651.0
HKD2_k127_5706897_1 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 337.0
HKD2_k127_5706897_2 iron ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001241 268.0
HKD2_k127_5706897_3 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.00000000000000000000000000000000000000000000000000000000005964 213.0
HKD2_k127_5706897_4 acetyltransferase - - - 0.00000000001466 77.0
HKD2_k127_5706897_5 Ankyrin repeat and kinase domain containing 1 K16289 - 2.7.11.1 0.0000000001089 72.0
HKD2_k127_5720707_0 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 7.519e-307 948.0
HKD2_k127_5720707_1 transporter - - - 2.922e-261 836.0
HKD2_k127_5720707_10 Cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000003776 198.0
HKD2_k127_5720707_11 PFAM cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000108 206.0
HKD2_k127_5720707_12 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000000009094 189.0
HKD2_k127_5720707_13 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000008315 190.0
HKD2_k127_5720707_14 Transfers electrons from cytochrome c551 to cytochrome oxidase - - - 0.00000000000000000000000000000000000000000003523 171.0
HKD2_k127_5720707_15 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000001683 165.0
HKD2_k127_5720707_16 Prokaryotic Cytochrome C oxidase subunit IV - - - 0.0000000000000000000000000000003093 126.0
HKD2_k127_5720707_17 COG0457 FOG TPR repeat - - - 0.0000000000000000007519 100.0
HKD2_k127_5720707_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000003184 72.0
HKD2_k127_5720707_19 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - 0.00000001887 58.0
HKD2_k127_5720707_2 PFAM TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 589.0
HKD2_k127_5720707_3 COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 525.0
HKD2_k127_5720707_4 DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 484.0
HKD2_k127_5720707_5 Cys/Met metabolism PLP-dependent enzyme K14287 - 2.6.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 479.0
HKD2_k127_5720707_6 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 358.0
HKD2_k127_5720707_7 amino acid peptide transporter K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 325.0
HKD2_k127_5720707_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001448 265.0
HKD2_k127_5720707_9 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000001778 252.0
HKD2_k127_5775545_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.019e-280 869.0
HKD2_k127_5775545_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.454e-219 708.0
HKD2_k127_5775545_10 Competence protein - GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000001935 138.0
HKD2_k127_5775545_11 SURF1-like protein K14998 - - 0.00000000000000000000000000001198 129.0
HKD2_k127_5775545_12 signal sequence binding - - - 0.00000003619 64.0
HKD2_k127_5775545_13 Protein of unknown function (DUF2909) - - - 0.0001175 47.0
HKD2_k127_5775545_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 1.751e-211 670.0
HKD2_k127_5775545_3 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 461.0
HKD2_k127_5775545_4 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 392.0
HKD2_k127_5775545_5 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 318.0
HKD2_k127_5775545_6 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 310.0
HKD2_k127_5775545_7 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.00000000000000000000000000000000000000000000000000000000006347 215.0
HKD2_k127_5775545_8 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000001669 175.0
HKD2_k127_5775545_9 PFAM Cytochrome c oxidase assembly protein CtaG Cox11 K02258 - - 0.00000000000000000000000000000000000000000000008597 173.0
HKD2_k127_587688_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - 1.878e-242 768.0
HKD2_k127_587688_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 514.0
HKD2_k127_587688_10 peptidase M23 - - - 0.000000000000000000000000000000000000000001358 169.0
HKD2_k127_587688_11 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000217 153.0
HKD2_k127_587688_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 476.0
HKD2_k127_587688_3 PFAM ErfK YbiS YcfS YnhG family protein K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 317.0
HKD2_k127_587688_4 PFAM peptidase K04774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 319.0
HKD2_k127_587688_5 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 297.0
HKD2_k127_587688_6 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005102 273.0
HKD2_k127_587688_7 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002032 258.0
HKD2_k127_587688_8 Phage tail sheath C-terminal domain K06907 - - 0.0000000000000000000000000000000000000000000000000000000000003533 231.0
HKD2_k127_587688_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000861 196.0
HKD2_k127_5889127_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 1.439e-225 715.0
HKD2_k127_5889127_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 389.0
HKD2_k127_5889127_2 Cardiolipin synthase K06132 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009291 308.0
HKD2_k127_5889127_3 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000006786 139.0
HKD2_k127_5889127_4 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000836 130.0
HKD2_k127_5889127_5 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000008253 65.0
HKD2_k127_5942670_0 Hexosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 406.0
HKD2_k127_5942670_1 glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009823 363.0
HKD2_k127_5942670_2 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 336.0
HKD2_k127_5942670_3 ABC transporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 320.0
HKD2_k127_5942670_4 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 310.0
HKD2_k127_5942670_5 glycosyl transferase family - - - 0.000000000000000000000000000000000005617 150.0
HKD2_k127_5942670_6 rRNA processing K21402 - - 0.00000000004677 72.0
HKD2_k127_5942670_7 Acyltransferase family - - - 0.00000002394 56.0
HKD2_k127_5958941_0 Urate oxidase N-terminal - - - 4.728e-281 902.0
HKD2_k127_5958941_1 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 582.0
HKD2_k127_5958941_10 Lytic polysaccharide mono-oxygenase, cellulose-degrading - - - 0.000000000000000000000000000000000000000000000000000000000000005009 222.0
HKD2_k127_5958941_11 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000001501 218.0
HKD2_k127_5958941_12 DSBA-like thioredoxin domain K07396 - - 0.0000000000000000000000000000000000000000000000000000001678 200.0
HKD2_k127_5958941_13 Planctomycete cytochrome C - - - 0.0000000000000000000000000000000003471 145.0
HKD2_k127_5958941_14 - - - - 0.00000000000000000000000000000001355 135.0
HKD2_k127_5958941_15 Bacterial protein of unknown function (DUF883) - - - 0.0000000000000000002071 94.0
HKD2_k127_5958941_16 Planctomycete cytochrome C - - - 0.000000000000001451 88.0
HKD2_k127_5958941_17 Transcriptional regulator - - - 0.00000000000003817 87.0
HKD2_k127_5958941_18 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000001341 76.0
HKD2_k127_5958941_19 Limonene-1,2-epoxide hydrolase catalytic domain K10533 - 3.3.2.8 0.000000000001714 74.0
HKD2_k127_5958941_2 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 517.0
HKD2_k127_5958941_3 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 382.0
HKD2_k127_5958941_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 342.0
HKD2_k127_5958941_5 Putative esterase K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 317.0
HKD2_k127_5958941_6 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001091 283.0
HKD2_k127_5958941_7 Protein of unknown function (DUF2914) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004086 250.0
HKD2_k127_5958941_8 HpcH/HpaI aldolase/citrate lyase family K00979,K01630,K02510 - 2.7.7.38,4.1.2.20,4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000009187 258.0
HKD2_k127_5958941_9 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000003257 233.0
HKD2_k127_6002984_0 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 329.0
HKD2_k127_6002984_1 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000009081 197.0
HKD2_k127_6002984_2 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000000000001865 186.0
HKD2_k127_6002984_3 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.0000001507 63.0
HKD2_k127_6002984_4 SnoaL-like domain - - - 0.0002417 50.0
HKD2_k127_603269_0 PQQ-like domain K00114 - 1.1.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 526.0
HKD2_k127_603269_1 Bacterial protein of unknown function (DUF839) - - - 0.0000000000000000000000000000000000000007963 156.0
HKD2_k127_603269_2 PFAM PBS lyase HEAT domain protein - - - 0.000000000003791 76.0
HKD2_k127_603269_3 metallopeptidase activity K01183,K01278,K03561,K12287 - 3.2.1.14,3.4.14.5 0.0000006674 61.0
HKD2_k127_603269_4 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.000009376 56.0
HKD2_k127_606616_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.122e-283 893.0
HKD2_k127_606616_1 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 1.841e-278 922.0
HKD2_k127_606616_10 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 366.0
HKD2_k127_606616_11 Oxidoreductase FAD-binding domain K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 366.0
HKD2_k127_606616_12 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 340.0
HKD2_k127_606616_13 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 355.0
HKD2_k127_606616_14 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 334.0
HKD2_k127_606616_15 PFAM N-acetylmuramoyl-L-alanine amidase K03806 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000009364 241.0
HKD2_k127_606616_16 adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000002757 218.0
HKD2_k127_606616_17 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000007436 214.0
HKD2_k127_606616_18 - - - - 0.00000000000000000000000000000000000000000000000000000000002828 216.0
HKD2_k127_606616_19 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000499 219.0
HKD2_k127_606616_2 twitching motility protein K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007795 526.0
HKD2_k127_606616_20 response regulator receiver K02657 - - 0.000000000000000000000000000000000000000000000000000002299 218.0
HKD2_k127_606616_21 Iron-sulfur cluster insertion protein ErpA K15724 - - 0.00000000000000000000000000000000000000000000000005053 179.0
HKD2_k127_606616_22 Pfam:PNPOx_C K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000001152 182.0
HKD2_k127_606616_23 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000001634 179.0
HKD2_k127_606616_24 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000000000000116 162.0
HKD2_k127_606616_25 TIGRFAM TonB family protein K03832 - - 0.0000000000000000000000000000003504 134.0
HKD2_k127_606616_26 Two component signalling adaptor domain K02659 - - 0.000000000000000000000000000001143 132.0
HKD2_k127_606616_27 cell shape determination - - - 0.000000000000000000000000000001864 125.0
HKD2_k127_606616_28 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000005092 103.0
HKD2_k127_606616_29 Two component signalling adaptor domain K06598 - - 0.0000000000000000002066 94.0
HKD2_k127_606616_3 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 508.0
HKD2_k127_606616_30 - - - - 0.00000000000000001249 91.0
HKD2_k127_606616_4 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 496.0
HKD2_k127_606616_5 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009286 418.0
HKD2_k127_606616_6 PFAM Type II secretion system protein E K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 412.0
HKD2_k127_606616_7 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 410.0
HKD2_k127_606616_8 chemotaxis protein K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 394.0
HKD2_k127_606616_9 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 381.0
HKD2_k127_6066713_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1313.0
HKD2_k127_6066713_1 FecR protein - - - 4.011e-279 895.0
HKD2_k127_6066713_2 Major facilitator Superfamily K03762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 386.0
HKD2_k127_6066713_3 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 301.0
HKD2_k127_6066713_4 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000003153 228.0
HKD2_k127_6066713_5 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000002793 205.0
HKD2_k127_6066713_6 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000002114 177.0
HKD2_k127_6094693_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 455.0
HKD2_k127_6094693_1 SurA N-terminal domain K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 362.0
HKD2_k127_6094693_2 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 340.0
HKD2_k127_6094693_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000001577 282.0
HKD2_k127_6094693_4 Nucleotidyl transferase K00992 - 2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000000000000001958 250.0
HKD2_k127_6117924_0 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 490.0
HKD2_k127_6117924_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004002 285.0
HKD2_k127_6117924_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001362 259.0
HKD2_k127_6117924_3 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002846 253.0
HKD2_k127_6117924_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000184 48.0
HKD2_k127_6164286_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.099e-201 639.0
HKD2_k127_6164286_1 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 513.0
HKD2_k127_6164286_2 cystathione gamma lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 445.0
HKD2_k127_6164286_3 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000257 271.0
HKD2_k127_6164286_4 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739,K01761 - 2.5.1.48,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000007539 268.0
HKD2_k127_6164286_5 rRNA processing K06968 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.186 0.000000000000000000000000000000000000000000000000000000000000000000001946 248.0
HKD2_k127_6164286_6 lactoylglutathione lyase activity K03088 - - 0.00000000000000000000000000000000000000000000000000000468 201.0
HKD2_k127_6164286_7 - - - - 0.000000000005178 67.0
HKD2_k127_6180230_0 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 541.0
HKD2_k127_6180230_1 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 471.0
HKD2_k127_6180230_2 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003602 278.0
HKD2_k127_6180230_3 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001234 287.0
HKD2_k127_61814_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 512.0
HKD2_k127_61814_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008097 375.0
HKD2_k127_61814_2 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009599 282.0
HKD2_k127_61814_3 Acetyltransferase (GNAT) domain K18816 - 2.3.1.82 0.00000000000000000000000003465 123.0
HKD2_k127_61814_4 protein conserved in bacteria K09914 - - 0.0000000000000000000000001121 119.0
HKD2_k127_6187474_0 response regulator receiver K07776 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 315.0
HKD2_k127_6187474_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003971 263.0
HKD2_k127_6187474_2 von willebrand factor, type A K11912 - 2.7.11.1 0.0000000000000000000000000000000124 130.0
HKD2_k127_6187474_3 - - - - 0.0000000000000000000000000000006686 134.0
HKD2_k127_6187474_4 PFAM PspA IM30 - - - 0.00000000000000000000000000002009 126.0
HKD2_k127_6196735_0 Aldehyde dehydrogenase family K00146 - 1.2.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 606.0
HKD2_k127_6196735_1 Aminotransferase class-III K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 499.0
HKD2_k127_6196735_2 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 413.0
HKD2_k127_6196735_3 SMART PUA domain containing protein K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 405.0
HKD2_k127_6196735_4 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 393.0
HKD2_k127_6196735_5 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 387.0
HKD2_k127_6196735_6 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000002116 214.0
HKD2_k127_6196735_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000003355 162.0
HKD2_k127_6196735_8 Transcriptional regulator K18301 - - 0.0000000000001737 79.0
HKD2_k127_6196735_9 Bacterial regulatory proteins, tetR family - - - 0.0000008941 59.0
HKD2_k127_6234977_0 Helicase K03724 - - 2.91e-321 1014.0
HKD2_k127_6234977_1 Protein kinase domain K12132 - 2.7.11.1 2.185e-206 676.0
HKD2_k127_6234977_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000005513 217.0
HKD2_k127_6234977_3 Inner membrane protein CreD - - - 0.0000005783 57.0
HKD2_k127_6235013_0 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 5.971e-202 663.0
HKD2_k127_6235013_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000001034 216.0
HKD2_k127_6235013_2 Sulfotransferase domain K01014 - 2.8.2.1 0.000000000000000000000000000000000000000000000000000000009348 212.0
HKD2_k127_6235013_3 Sulfotransferase domain K01014 - 2.8.2.1 0.0000000000000000000000000000000005189 136.0
HKD2_k127_6378208_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 526.0
HKD2_k127_6378208_1 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 490.0
HKD2_k127_6378208_10 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.00000000000000000000000172 111.0
HKD2_k127_6378208_2 signal peptide peptidase K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 469.0
HKD2_k127_6378208_3 carbohydrate transport K11688,K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 311.0
HKD2_k127_6378208_4 FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003089 289.0
HKD2_k127_6378208_5 FeS assembly SUF system protein SufT - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005943 261.0
HKD2_k127_6378208_6 TRAP transporter T-component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002194 261.0
HKD2_k127_6378208_7 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000003336 182.0
HKD2_k127_6378208_8 Histidine phosphatase superfamily (branch 1) K08296 - - 0.0000000000000000000000000000000002358 145.0
HKD2_k127_6378208_9 PFAM RNA-binding S4 domain protein K04762 - - 0.00000000000000000000000007913 113.0
HKD2_k127_6392809_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 582.0
HKD2_k127_6392809_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 528.0
HKD2_k127_6392809_10 SH3 domain K07184 - - 0.00000000000000000000000000000000000008859 150.0
HKD2_k127_6392809_11 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000007698 141.0
HKD2_k127_6392809_12 YceI-like domain - - - 0.00000000000000000000000001037 119.0
HKD2_k127_6392809_13 - - - - 0.00000000000000000000000002965 117.0
HKD2_k127_6392809_14 Protein of unknown function (DUF1249) K09920 - - 0.00000000000000000000003905 106.0
HKD2_k127_6392809_15 diguanylate cyclase - - - 0.00000000003054 75.0
HKD2_k127_6392809_16 Recombinase zinc beta ribbon domain - - - 0.0000000008907 63.0
HKD2_k127_6392809_17 transposition K07483,K07497 - - 0.000009607 47.0
HKD2_k127_6392809_2 MotA/TolQ/ExbB proton channel family K02556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 431.0
HKD2_k127_6392809_3 PFAM MotA TolQ ExbB proton channel K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 287.0
HKD2_k127_6392809_4 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001467 263.0
HKD2_k127_6392809_5 PFAM Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001201 263.0
HKD2_k127_6392809_6 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000003219 246.0
HKD2_k127_6392809_7 COG1360 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000004018 217.0
HKD2_k127_6392809_8 - - - - 0.00000000000000000000000000000000000000000000000001791 188.0
HKD2_k127_6392809_9 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000001476 146.0
HKD2_k127_6395285_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 5.628e-260 810.0
HKD2_k127_6395285_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 1.865e-247 777.0
HKD2_k127_6395285_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 582.0
HKD2_k127_6395285_3 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000002528 217.0
HKD2_k127_6395285_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000004905 163.0
HKD2_k127_6395285_5 pfam nudix K08310 - 3.6.1.67 0.0000000000000000000000000000177 134.0
HKD2_k127_6395285_6 Regulatory protein, FmdB family - - - 0.00000000000000000000000000009296 119.0
HKD2_k127_6520336_0 OmpA family - - - 0.0 1875.0
HKD2_k127_6520336_1 signal transduction histidine kinase K15011 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 298.0
HKD2_k127_6520336_2 - - - - 0.000000000000000000000000000000000000000000000000000000002736 217.0
HKD2_k127_6520336_3 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000002299 204.0
HKD2_k127_6520336_4 response regulator K15012 - - 0.000000000000000000000000000000000008032 141.0
HKD2_k127_6520336_5 Domain of unknown function DUF11 - - - 0.00000000000000000000000000000000003241 137.0
HKD2_k127_6520336_6 cyclic nucleotide binding K07003 - - 0.0001219 48.0
HKD2_k127_652747_1 NMT1-like family - - - 0.00000000001811 66.0
HKD2_k127_6549888_0 Dehydrogenase E1 component K00164 GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 0.0 1099.0
HKD2_k127_6549888_1 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 5.196e-242 758.0
HKD2_k127_6549888_10 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 454.0
HKD2_k127_6549888_11 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 438.0
HKD2_k127_6549888_12 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 318.0
HKD2_k127_6549888_13 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 313.0
HKD2_k127_6549888_14 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000225 246.0
HKD2_k127_6549888_15 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000007524 223.0
HKD2_k127_6549888_16 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000001771 202.0
HKD2_k127_6549888_17 Protein of unknown function (DUF3187) - - - 0.000000000000000000000000000000000000000000000005744 185.0
HKD2_k127_6549888_18 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000151 175.0
HKD2_k127_6549888_19 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000001754 155.0
HKD2_k127_6549888_2 PQQ-like domain K00114 - 1.1.2.8 7.153e-224 704.0
HKD2_k127_6549888_20 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000005752 168.0
HKD2_k127_6549888_21 Biopolymer transport protein K03560 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000004668 156.0
HKD2_k127_6549888_22 Ion channel - - - 0.00000000000000000000000000000000006394 151.0
HKD2_k127_6549888_23 Tol-Pal system-associated acyl-CoA thioesterase K07107 - - 0.000000000000000000000000000000001619 133.0
HKD2_k127_6549888_24 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000004173 135.0
HKD2_k127_6549888_25 COG3474 Cytochrome c2 K08738 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944 - 0.00000000000000000000002209 115.0
HKD2_k127_6549888_26 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000001038 81.0
HKD2_k127_6549888_27 - - - - 0.00000000004973 68.0
HKD2_k127_6549888_28 - - - - 0.00000000005806 73.0
HKD2_k127_6549888_29 - - - - 0.0000000007057 66.0
HKD2_k127_6549888_3 Xylulose kinase K00854 GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.17 2.638e-212 669.0
HKD2_k127_6549888_30 TonB C terminal K03646 - - 0.00000002253 66.0
HKD2_k127_6549888_31 - - - - 0.00007066 46.0
HKD2_k127_6549888_4 Sugar phosphate isomerases epimerases - - - 8.128e-204 637.0
HKD2_k127_6549888_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 615.0
HKD2_k127_6549888_6 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 567.0
HKD2_k127_6549888_7 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 552.0
HKD2_k127_6549888_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 505.0
HKD2_k127_6549888_9 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 482.0
HKD2_k127_6601162_0 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 586.0
HKD2_k127_6601162_1 Belongs to the GMC oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 542.0
HKD2_k127_6601162_10 TonB-dependent receptor K02014,K02456,K02457,K02458,K10926,K10930,K10931 GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 - 0.000000000004726 79.0
HKD2_k127_6601162_11 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.000000000004726 79.0
HKD2_k127_6601162_2 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007415 426.0
HKD2_k127_6601162_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 366.0
HKD2_k127_6601162_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 323.0
HKD2_k127_6601162_5 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000001502 254.0
HKD2_k127_6601162_6 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000003909 171.0
HKD2_k127_6601162_7 Protein of unknown function (DUF1587) - - - 0.00000000000000000000000000000000000000000001021 175.0
HKD2_k127_6601162_8 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000002566 173.0
HKD2_k127_6601162_9 Domain of unknown function (DUF4440) - - - 0.00000000000009916 79.0
HKD2_k127_6633917_0 Peptidase C39 family K13409 - - 6.67e-262 833.0
HKD2_k127_6633917_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 426.0
HKD2_k127_6633917_10 Aspartyl protease - - - 0.0000000000000000000000000000000006651 151.0
HKD2_k127_6633917_11 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000008685 137.0
HKD2_k127_6633917_13 Phospholipid methyltransferase - - - 0.000000000000000000007964 101.0
HKD2_k127_6633917_14 - - - - 0.000000004415 66.0
HKD2_k127_6633917_15 Beta-lactamase - - - 0.00001278 57.0
HKD2_k127_6633917_3 HlyD family secretion protein K13408 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 339.0
HKD2_k127_6633917_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 319.0
HKD2_k127_6633917_5 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 302.0
HKD2_k127_6633917_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000003465 228.0
HKD2_k127_6633917_7 gluconolactonase activity K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000003498 207.0
HKD2_k127_6633917_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000001449 197.0
HKD2_k127_6717001_0 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 508.0
HKD2_k127_6717001_1 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 400.0
HKD2_k127_6717001_2 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 362.0
HKD2_k127_6717001_3 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004947 260.0
HKD2_k127_6717001_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 0.000000009545 59.0
HKD2_k127_673025_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 621.0
HKD2_k127_673025_1 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 430.0
HKD2_k127_673025_2 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 342.0
HKD2_k127_673025_3 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 321.0
HKD2_k127_673025_4 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000001839 267.0
HKD2_k127_673025_5 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000136 262.0
HKD2_k127_673025_6 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000007399 169.0
HKD2_k127_673025_7 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000009116 168.0
HKD2_k127_673025_8 Belongs to the skp family K06142 - - 0.000000000000000000002656 102.0
HKD2_k127_6782624_0 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 400.0
HKD2_k127_6782624_1 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 287.0
HKD2_k127_6782624_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008602 276.0
HKD2_k127_6782624_3 Protein of unknown function (DUF2802) - - - 0.0008199 48.0
HKD2_k127_6799613_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1691.0
HKD2_k127_6799613_1 COG0493 NADPH-dependent glutamate synthase beta chain and K00266 - 1.4.1.13,1.4.1.14 1.53e-239 750.0
HKD2_k127_6799613_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 4.327e-226 714.0
HKD2_k127_6799613_3 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 529.0
HKD2_k127_6799613_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 400.0
HKD2_k127_6799613_5 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000005943 243.0
HKD2_k127_6799613_6 Outer membrane efflux protein K15725 - - 0.0000001258 65.0
HKD2_k127_6823974_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1433.0
HKD2_k127_6823974_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.177e-261 819.0
HKD2_k127_6823974_10 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 355.0
HKD2_k127_6823974_11 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002517 266.0
HKD2_k127_6823974_12 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000002831 175.0
HKD2_k127_6823974_13 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000000000000007201 135.0
HKD2_k127_6823974_14 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.0000000000000000000000000000000005277 134.0
HKD2_k127_6823974_15 protein conserved in bacteria K09948 - - 0.0000000000000000000000000000000008188 138.0
HKD2_k127_6823974_16 SnoaL-like domain K06893 - - 0.000000000000000000000000000000001244 134.0
HKD2_k127_6823974_17 belongs to the Fur family K09826 - - 0.00000000000000000000000000000002252 134.0
HKD2_k127_6823974_18 Prokaryotic cytochrome b561 K12262 - - 0.00000000000000000000000000003634 124.0
HKD2_k127_6823974_19 - - - - 0.000000000000000000000003616 117.0
HKD2_k127_6823974_2 Flavin containing amine oxidoreductase - - - 1.391e-214 687.0
HKD2_k127_6823974_20 Type II transport protein GspH K08084 - - 0.00000000000000000000003065 106.0
HKD2_k127_6823974_21 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.0000000000000000002654 104.0
HKD2_k127_6823974_22 Binds directly to 16S ribosomal RNA K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000006636 87.0
HKD2_k127_6823974_23 - - - - 0.0000000000001139 76.0
HKD2_k127_6823974_24 Type IV Pilus-assembly protein W K02672 - - 0.000000000001289 81.0
HKD2_k127_6823974_25 COG4967 Tfp pilus assembly protein PilV - - - 0.000000000001502 81.0
HKD2_k127_6823974_27 Type II transport protein GspH K08084 - - 0.00000004534 63.0
HKD2_k127_6823974_28 Pilus assembly protein PilX K02673 - - 0.00002123 55.0
HKD2_k127_6823974_3 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 617.0
HKD2_k127_6823974_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 513.0
HKD2_k127_6823974_5 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 498.0
HKD2_k127_6823974_6 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 485.0
HKD2_k127_6823974_7 MatE - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 473.0
HKD2_k127_6823974_8 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 433.0
HKD2_k127_6823974_9 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 390.0
HKD2_k127_6864546_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 578.0
HKD2_k127_6864546_1 serine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003242 271.0
HKD2_k127_6864546_2 TraB family - - - 0.0000000000000000000000000000000000000000000000000001664 206.0
HKD2_k127_6864546_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000005569 158.0
HKD2_k127_6864546_4 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000000003985 153.0
HKD2_k127_6864546_5 spectrin binding - - - 0.000000000000004013 86.0
HKD2_k127_6864546_6 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000001268 79.0
HKD2_k127_6864546_7 Anti-sigma-K factor rskA - - - 0.000629 51.0
HKD2_k127_690241_0 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00467,K16422 - 1.1.2.3,1.1.3.46,1.13.12.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 394.0
HKD2_k127_690241_1 Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA K00556 GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360 2.1.1.34 0.000000000000000000000000000000000000000000000000000000000000001922 229.0
HKD2_k127_690241_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000003083 192.0
HKD2_k127_690241_3 Phospholipid N-methyltransferase - - - 0.000000000000000000000000000000000000003843 155.0
HKD2_k127_690241_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000005044 130.0
HKD2_k127_690241_5 - - - - 0.0000000000004387 71.0
HKD2_k127_690241_6 - - - - 0.000003151 52.0
HKD2_k127_690241_7 phosphoglycerate mutase - - - 0.00002329 54.0
HKD2_k127_6924171_0 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 539.0
HKD2_k127_6924171_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 456.0
HKD2_k127_6924171_2 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 391.0
HKD2_k127_6924171_3 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001763 286.0
HKD2_k127_6924171_4 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004472 304.0
HKD2_k127_6924171_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.0000000000000000000000004243 106.0
HKD2_k127_6924171_6 decarboxylase K01607 - 4.1.1.44 0.000000000000000000001382 108.0
HKD2_k127_6944175_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 8.485e-270 842.0
HKD2_k127_6944175_1 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 1.124e-231 723.0
HKD2_k127_6944175_10 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001705 252.0
HKD2_k127_6944175_11 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000285 251.0
HKD2_k127_6944175_12 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517,K12974 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 0.000000000000000000000000000000000000000000000000000000000000006573 230.0
HKD2_k127_6944175_13 Lipid A biosynthesis K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000008276 218.0
HKD2_k127_6944175_14 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000003518 188.0
HKD2_k127_6944175_15 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.000000000000000000000000000000000000000000000000008562 192.0
HKD2_k127_6944175_16 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000003405 168.0
HKD2_k127_6944175_17 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000005454 171.0
HKD2_k127_6944175_18 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000008916 165.0
HKD2_k127_6944175_19 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000477 163.0
HKD2_k127_6944175_2 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 623.0
HKD2_k127_6944175_20 Thioredoxin-like - - - 0.00000000000000000000000001042 119.0
HKD2_k127_6944175_21 RES - - - 0.0000000000000000000000001747 112.0
HKD2_k127_6944175_22 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000003289 106.0
HKD2_k127_6944175_23 Protein of unknown function (DUF2384) - - - 0.00000000000000002323 91.0
HKD2_k127_6944175_24 protein conserved in bacteria - - - 0.000000000000002802 91.0
HKD2_k127_6944175_25 zinc-ribbon domain - - - 0.0000000003214 61.0
HKD2_k127_6944175_26 SnoaL-like polyketide cyclase - - - 0.0003452 53.0
HKD2_k127_6944175_3 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 597.0
HKD2_k127_6944175_4 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 487.0
HKD2_k127_6944175_5 Molecular chaperone. Has ATPase activity K04079 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 453.0
HKD2_k127_6944175_6 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 396.0
HKD2_k127_6944175_7 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 382.0
HKD2_k127_6944175_8 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 372.0
HKD2_k127_6944175_9 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000222 282.0
HKD2_k127_6967249_0 Glycogen debranching enzyme - - - 0.0 1412.0
HKD2_k127_6967249_1 Feruloyl esterase K21105 - 3.1.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 573.0
HKD2_k127_6967249_10 Sugar efflux transporter for intercellular exchange - - - 0.000000000000000000000000000000000000000000002128 169.0
HKD2_k127_6967249_11 protein conserved in bacteria K01790 GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704 5.1.3.13 0.0000000000000000000001932 101.0
HKD2_k127_6967249_12 Esterase PHB depolymerase - - - 0.00000001848 64.0
HKD2_k127_6967249_3 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 449.0
HKD2_k127_6967249_5 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 391.0
HKD2_k127_6967249_6 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 352.0
HKD2_k127_6967249_7 COG0477 Permeases of the major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000283 244.0
HKD2_k127_6967249_8 RNA pseudouridylate synthase K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000003404 224.0
HKD2_k127_6967249_9 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000178 222.0
HKD2_k127_7005985_0 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 556.0
HKD2_k127_7005985_1 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 509.0
HKD2_k127_7005985_2 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 354.0
HKD2_k127_7005985_3 Sensors of blue-light using FAD - - - 0.0000000000000000000000000000000000000000531 155.0
HKD2_k127_7005985_4 - - - - 0.000000000000000000005233 98.0
HKD2_k127_7102457_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1300.0
HKD2_k127_7102457_1 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 362.0
HKD2_k127_7102457_2 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 317.0
HKD2_k127_7102457_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006481 291.0
HKD2_k127_7102457_4 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001671 273.0
HKD2_k127_7102457_5 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000331 220.0
HKD2_k127_7102457_6 dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000008968 174.0
HKD2_k127_7102457_7 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000000000001366 164.0
HKD2_k127_7102457_8 Amino acid permease - - - 0.00000000000000000000000001091 120.0
HKD2_k127_7118377_0 PFAM glycoside hydrolase, family 3 domain protein K05349 - 3.2.1.21 1.862e-204 646.0
HKD2_k127_7118377_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000005915 261.0
HKD2_k127_7118377_2 - - - - 0.00000000000000000001199 97.0
HKD2_k127_7118377_4 MacB-like periplasmic core domain - - - 0.000000000003047 70.0
HKD2_k127_7118377_5 Belongs to the SlyX family K03745 - - 0.00009075 51.0
HKD2_k127_7248320_0 Predicted Permease Membrane Region K07085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 469.0
HKD2_k127_7248320_1 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000345 182.0
HKD2_k127_7248320_2 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000008131 77.0
HKD2_k127_737208_0 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 363.0
HKD2_k127_737208_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 316.0
HKD2_k127_737208_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 289.0
HKD2_k127_737208_3 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006957 259.0
HKD2_k127_737208_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000006043 208.0
HKD2_k127_737208_5 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000000000004845 160.0
HKD2_k127_737208_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000002727 116.0
HKD2_k127_737208_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.0000000000000002345 83.0
HKD2_k127_7469174_0 UPF0210 protein K09157 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 466.0
HKD2_k127_7469174_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000008392 221.0
HKD2_k127_7469174_11 - - - - 0.0005002 48.0
HKD2_k127_7469174_2 Uncharacterised ACR (DUF711) K09157 - - 0.000000000000000000000000000000000000000000000000000000000003535 210.0
HKD2_k127_7469174_3 protein domain, possibly involved in tellurite resistance - - - 0.0000000000000000000000000000000000000000000000000005446 208.0
HKD2_k127_7469174_4 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000001078 170.0
HKD2_k127_7469174_5 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000005059 140.0
HKD2_k127_7469174_6 endonuclease activity - - - 0.00000000000000000000000000000002401 130.0
HKD2_k127_7469174_7 Belongs to the UPF0237 family K07166 - - 0.00000000000000000000000000000216 123.0
HKD2_k127_7469174_8 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000000000000000009013 108.0
HKD2_k127_7469174_9 Domain of unknown function (DUF1840) - - - 0.00000000000000001388 87.0
HKD2_k127_7607901_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1199.0
HKD2_k127_7607901_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 2.061e-201 638.0
HKD2_k127_7607901_10 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.000000000000000000000000000000000000000000369 162.0
HKD2_k127_7607901_11 signal transduction histidine kinase K07637 - 2.7.13.3 0.0000000000000000000000000000000000000000005022 168.0
HKD2_k127_7607901_12 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00000000000000000000000000000000000000002634 162.0
HKD2_k127_7607901_13 protein acetylation - - - 0.000000000000000000000001189 109.0
HKD2_k127_7607901_14 outer membrane lipoprotein - - - 0.0000000000000000000006841 104.0
HKD2_k127_7607901_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 561.0
HKD2_k127_7607901_3 COG4257 Streptogramin lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 431.0
HKD2_k127_7607901_4 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 386.0
HKD2_k127_7607901_5 Uncharacterized protein conserved in bacteria (DUF2333) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007317 358.0
HKD2_k127_7607901_6 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 321.0
HKD2_k127_7607901_7 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 291.0
HKD2_k127_7607901_8 Nucleoside triphosphate K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002564 284.0
HKD2_k127_7607901_9 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000001582 257.0
HKD2_k127_7653995_0 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 495.0
HKD2_k127_7653995_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 489.0
HKD2_k127_7653995_2 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 435.0
HKD2_k127_7653995_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 309.0
HKD2_k127_7653995_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006035 297.0
HKD2_k127_7653995_5 endonuclease activity - - - 0.00000000000000000000000000000000000000000000000000000000000002751 233.0
HKD2_k127_7653995_6 electron transfer activity - - - 0.0000000000000000000000000000000000000000000000000000001076 201.0
HKD2_k127_7653995_7 protein conserved in bacteria - - - 0.000000000000000000000000000000009904 136.0
HKD2_k127_7653995_8 phosphatase activity K07025,K20862 - 3.1.3.102,3.1.3.104 0.0000000000000000000000000000005535 141.0
HKD2_k127_7653995_9 protein conserved in bacteria K15539 - - 0.0000000003141 66.0
HKD2_k127_7654622_0 Glutathione S-transferase, C-terminal domain K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 501.0
HKD2_k127_7654622_1 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 485.0
HKD2_k127_7654622_2 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 451.0
HKD2_k127_7654622_3 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 377.0
HKD2_k127_7654622_4 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 366.0
HKD2_k127_7654622_5 Glutathione S-transferase, N-terminal domain K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 308.0
HKD2_k127_7654622_6 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 310.0
HKD2_k127_7654622_7 COG2040 Homocysteine selenocysteine methylase (S-methylmethionine-dependent) K00547 - 2.1.1.10 0.000000000000000000000000000002509 132.0
HKD2_k127_7654622_8 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000003494 128.0
HKD2_k127_7668781_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1340.0
HKD2_k127_7668781_1 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 2.567e-246 777.0
HKD2_k127_7668781_10 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000005938 249.0
HKD2_k127_7668781_11 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000000005299 197.0
HKD2_k127_7668781_12 nitrogen regulatory protein P-II K04751,K04752 - - 0.000000000000000000000000000000000000000000000001474 177.0
HKD2_k127_7668781_13 - - - - 0.000000000000000000000000000000000000000000002232 170.0
HKD2_k127_7668781_14 TPR repeat - - - 0.000000000000000000000000000000000015 147.0
HKD2_k127_7668781_15 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000004077 132.0
HKD2_k127_7668781_16 Glutathione peroxidase - - - 0.00000000000000000000000000000009304 132.0
HKD2_k127_7668781_17 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000192 134.0
HKD2_k127_7668781_18 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000001687 102.0
HKD2_k127_7668781_19 MerC mercury resistance protein - - - 0.0000000000000000005266 93.0
HKD2_k127_7668781_2 Tetratricopeptide repeat - - - 5.864e-228 737.0
HKD2_k127_7668781_20 - - - - 0.0000000000003299 82.0
HKD2_k127_7668781_3 Ammonium transporter K03320 - - 2.866e-226 708.0
HKD2_k127_7668781_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 435.0
HKD2_k127_7668781_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 313.0
HKD2_k127_7668781_6 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 289.0
HKD2_k127_7668781_7 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K02056,K05776,K10441,K10539,K10542,K10545,K10548 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004541 292.0
HKD2_k127_7668781_8 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009289 260.0
HKD2_k127_7668781_9 Inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.000000000000000000000000000000000000000000000000000000000000000000001362 244.0
HKD2_k127_7678417_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001685 285.0
HKD2_k127_7678417_1 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271,K12961 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000006441 259.0
HKD2_k127_7678417_2 PFAM LppC K07121 - - 0.000000000000000000000000000000000000000000000000000000000000000000511 253.0
HKD2_k127_7678417_3 - - - - 0.0000000000000000000000002977 107.0
HKD2_k127_7678417_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000001973 109.0
HKD2_k127_7678417_5 Belongs to the UPF0102 family K07460 - - 0.000000000000000003618 98.0
HKD2_k127_77455_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 546.0
HKD2_k127_77455_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 533.0
HKD2_k127_77455_10 membrane - - - 0.00000002135 65.0
HKD2_k127_77455_2 CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 435.0
HKD2_k127_77455_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 372.0
HKD2_k127_77455_4 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 355.0
HKD2_k127_77455_5 phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001253 286.0
HKD2_k127_77455_6 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000003071 226.0
HKD2_k127_77455_7 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000008939 178.0
HKD2_k127_77455_8 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000001033 164.0
HKD2_k127_77455_9 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000002482 138.0
HKD2_k127_7768544_0 A predicted alpha-helical domain with a conserved ER motif. - - - 5.144e-222 716.0
HKD2_k127_7768544_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 344.0
HKD2_k127_7768544_2 transglutaminase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 314.0
HKD2_k127_7768544_3 Putative amidoligase enzyme (DUF2126) - - - 0.000000000000000000000000000000000000000000003026 165.0
HKD2_k127_7777245_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 3.496e-201 638.0
HKD2_k127_7777245_1 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 565.0
HKD2_k127_7777245_10 cell wall glycoprotein biosynthetic process K00344,K01809,K01840,K03431,K04035,K15778,K16881 GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.14.13.81,1.6.5.5,2.7.7.13,5.3.1.8,5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002396 266.0
HKD2_k127_7777245_11 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000001603 237.0
HKD2_k127_7777245_12 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000137 200.0
HKD2_k127_7777245_13 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000631 200.0
HKD2_k127_7777245_14 Sortase family K07284 - 3.4.22.70 0.0000000000000000000000000000000000004355 141.0
HKD2_k127_7777245_15 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.0000000000000000000000000000005106 132.0
HKD2_k127_7777245_16 membrane protein (DUF2306) - - - 0.000000000000000000000000000001566 128.0
HKD2_k127_7777245_17 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000678 98.0
HKD2_k127_7777245_18 - - - - 0.0000000000000009783 91.0
HKD2_k127_7777245_19 Putative restriction endonuclease - - - 0.000000000000007758 76.0
HKD2_k127_7777245_2 Catalyzes cross-linking of the peptidoglycan cell wall K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008055 565.0
HKD2_k127_7777245_20 - - - - 0.00000000000146 76.0
HKD2_k127_7777245_21 Belongs to the UPF0250 family K09158 - - 0.000000000001464 77.0
HKD2_k127_7777245_22 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family - - - 0.0001292 55.0
HKD2_k127_7777245_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 547.0
HKD2_k127_7777245_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 429.0
HKD2_k127_7777245_5 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 409.0
HKD2_k127_7777245_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 357.0
HKD2_k127_7777245_7 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 317.0
HKD2_k127_7777245_8 Lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 308.0
HKD2_k127_7777245_9 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001667 261.0
HKD2_k127_7790152_0 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 387.0
HKD2_k127_7790152_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 313.0
HKD2_k127_7790152_2 unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 317.0
HKD2_k127_7790152_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000003923 235.0
HKD2_k127_7790152_4 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000001217 109.0
HKD2_k127_7790152_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000002357 96.0
HKD2_k127_7790152_6 - - - - 0.000000000001371 76.0
HKD2_k127_7790152_7 - - - - 0.00001554 54.0
HKD2_k127_7813257_0 Aminotransferase class-III K01845 - 5.4.3.8 3.479e-244 766.0
HKD2_k127_7813257_1 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 346.0
HKD2_k127_7813257_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 293.0
HKD2_k127_7813257_3 Phospholipid N-methyltransferase - - - 0.000000000000000000000000000000000000004269 158.0
HKD2_k127_7819598_0 TIGRFAM penicillin-binding protein, 1A K05366 - 2.4.1.129,3.4.16.4 3.445e-207 672.0
HKD2_k127_7819598_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 311.0
HKD2_k127_7819598_2 mRNA catabolic process - - - 0.00000000000000000000000000000002871 136.0
HKD2_k127_7822079_0 UPF0761 membrane protein K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002041 265.0
HKD2_k127_7822079_1 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001805 255.0
HKD2_k127_7822079_2 Belongs to the SAICAR synthetase family K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000002561 180.0
HKD2_k127_7876147_0 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 473.0
HKD2_k127_7876147_1 flagellar hook-associated protein K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 449.0
HKD2_k127_7876147_10 Flagellar rod assembly protein muramidase FlgJ K02395 - - 0.00000000000000000000000000000000000000000000000000000006413 207.0
HKD2_k127_7876147_11 flagellar protein FliS K02422 - - 0.0000000000000000000000000000000002824 135.0
HKD2_k127_7876147_12 FlaG protein K06603 - - 0.00000000002752 69.0
HKD2_k127_7876147_2 Flagellar hook protein FlgE K02390 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 406.0
HKD2_k127_7876147_3 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 391.0
HKD2_k127_7876147_4 basal body rod K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 370.0
HKD2_k127_7876147_5 Fis family transcriptional regulator K10941 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 359.0
HKD2_k127_7876147_6 Belongs to the bacterial flagellin family K02397 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003979 307.0
HKD2_k127_7876147_7 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004671 294.0
HKD2_k127_7876147_8 Belongs to the flagella basal body rod proteins family K02391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004155 259.0
HKD2_k127_7876147_9 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.000000000000000000000000000000000000000000000000000000000001702 216.0
HKD2_k127_7951749_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1498.0
HKD2_k127_7951749_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.1e-322 998.0
HKD2_k127_7951749_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 316.0
HKD2_k127_7951749_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 313.0
HKD2_k127_7951749_12 PFAM Helix-turn-helix, type 11 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 292.0
HKD2_k127_7951749_13 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004712 284.0
HKD2_k127_7951749_14 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000008594 250.0
HKD2_k127_7951749_15 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000003011 235.0
HKD2_k127_7951749_16 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000000000000000000000000000000000003443 213.0
HKD2_k127_7951749_17 ribonuclease inhibitor activity - - - 0.000000000000000000000000000000000000000000000000000000000006668 231.0
HKD2_k127_7951749_18 Lipid A biosynthesis K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000004996 216.0
HKD2_k127_7951749_19 MerR family regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000003191 204.0
HKD2_k127_7951749_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 7.97e-252 789.0
HKD2_k127_7951749_20 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000002838 175.0
HKD2_k127_7951749_21 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000002301 160.0
HKD2_k127_7951749_22 protein import - - - 0.000000000000000000000000001992 128.0
HKD2_k127_7951749_23 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000001193 83.0
HKD2_k127_7951749_24 histone H2A K63-linked ubiquitination K01768 - 4.6.1.1 0.00000001221 67.0
HKD2_k127_7951749_25 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000005975 53.0
HKD2_k127_7951749_3 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 4.691e-229 738.0
HKD2_k127_7951749_4 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 466.0
HKD2_k127_7951749_5 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 420.0
HKD2_k127_7951749_6 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 400.0
HKD2_k127_7951749_7 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 335.0
HKD2_k127_7951749_8 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 334.0
HKD2_k127_7951749_9 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 311.0
HKD2_k127_795228_0 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007106 336.0
HKD2_k127_795228_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 304.0
HKD2_k127_795228_2 PFAM AsmA family protein K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000327 305.0
HKD2_k127_795228_3 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 292.0
HKD2_k127_795228_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000002485 231.0
HKD2_k127_795228_5 Histidine kinase - - - 0.000000000000000000000000000000000000007803 157.0
HKD2_k127_795228_6 GGDEF domain - - - 0.0000000002748 71.0
HKD2_k127_7969911_0 Outer membrane receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 547.0
HKD2_k127_7969911_1 PQQ-like domain K00114 - 1.1.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 511.0
HKD2_k127_7969911_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 381.0
HKD2_k127_7969911_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000006603 219.0
HKD2_k127_7969911_4 Cytochrome c - - - 0.0000000000000000000000000002561 128.0
HKD2_k127_7979324_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 8.499e-199 629.0
HKD2_k127_7979324_1 Major facilitator superfamily K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 463.0
HKD2_k127_7979324_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 436.0
HKD2_k127_7979324_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 391.0
HKD2_k127_7979324_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000000000000003038 179.0
HKD2_k127_7979324_5 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000009139 142.0
HKD2_k127_7979324_6 receptor - - - 0.000003014 53.0
HKD2_k127_79994_0 PFAM PEBP family protein K06910 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000001852 215.0
HKD2_k127_79994_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000007267 171.0
HKD2_k127_79994_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000002098 172.0
HKD2_k127_79994_3 Protein of unknown function (DUF1289) - - - 0.00000000000004463 76.0
HKD2_k127_79994_4 - - - - 0.00000000005586 67.0
HKD2_k127_8039524_0 Sulfatase K01130 - 3.1.6.1 1.279e-303 941.0
HKD2_k127_8039524_1 ABC transporter - GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896 - 4.572e-247 775.0
HKD2_k127_8039524_10 Glutathione-dependent formaldehyde-activating enzyme K03396 - 4.4.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 304.0
HKD2_k127_8039524_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000024 297.0
HKD2_k127_8039524_12 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000002716 222.0
HKD2_k127_8039524_13 Two component transcriptional regulator, winged helix family - - - 0.000000000000000000000000000000000000000000000000000000000000006593 244.0
HKD2_k127_8039524_14 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000000000000000065 216.0
HKD2_k127_8039524_15 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000001374 197.0
HKD2_k127_8039524_16 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000008974 188.0
HKD2_k127_8039524_17 GrpB protein - - - 0.000000000000000000000000000000000000000005748 163.0
HKD2_k127_8039524_18 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000008575 115.0
HKD2_k127_8039524_19 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000001801 118.0
HKD2_k127_8039524_2 FAD linked oxidase domain protein K05797 - 1.17.99.1 1.331e-214 679.0
HKD2_k127_8039524_20 - - - - 0.0000000000000000000789 94.0
HKD2_k127_8039524_21 - - - - 0.00000000000001078 78.0
HKD2_k127_8039524_22 PPIC-type PPIASE domain - - - 0.0000000000001291 73.0
HKD2_k127_8039524_23 lactoylglutathione lyase activity - - - 0.000000000000262 79.0
HKD2_k127_8039524_24 lactoylglutathione lyase activity - - - 0.000000000002236 72.0
HKD2_k127_8039524_26 Belongs to the UPF0235 family K09131 - - 0.00000000006121 68.0
HKD2_k127_8039524_27 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000003746 68.0
HKD2_k127_8039524_28 - - - - 0.00004497 54.0
HKD2_k127_8039524_29 Bacterial regulatory proteins, tetR family - - - 0.00005511 53.0
HKD2_k127_8039524_3 DNA topological change - - - 1.729e-207 670.0
HKD2_k127_8039524_4 Tfp pilus assembly protein FimV - - - 2.443e-195 622.0
HKD2_k127_8039524_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005131 577.0
HKD2_k127_8039524_6 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 545.0
HKD2_k127_8039524_7 His Kinase A (phosphoacceptor) domain K07641,K10819 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 413.0
HKD2_k127_8039524_8 HupE / UreJ protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 348.0
HKD2_k127_8039524_9 Ankyrin repeats (many copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 346.0
HKD2_k127_8055991_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 7.084e-298 923.0
HKD2_k127_8055991_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 537.0
HKD2_k127_8055991_2 SMART transcription factor jumonji jmjC K18850 - 1.14.11.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 404.0
HKD2_k127_8055991_4 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000000000000000000000000005875 201.0
HKD2_k127_8055991_5 Mg-protoporphyrin IX monomethyl ester oxidative cyclase K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000005086 198.0
HKD2_k127_8055991_6 Carboxylesterase family - - - 0.000000000000000000000000000000000000004071 161.0
HKD2_k127_8055991_7 Cupin 2, conserved barrel domain protein K11477 - - 0.000000000000000000000000005179 123.0
HKD2_k127_812705_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 482.0
HKD2_k127_812705_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 429.0
HKD2_k127_812705_2 N-acetylmuramoyl-L-alanine amidase K01448 GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 405.0
HKD2_k127_812705_3 polyphosphate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 314.0
HKD2_k127_812705_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000001823 243.0
HKD2_k127_812705_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000005005 123.0
HKD2_k127_812705_6 cyclic nucleotide-binding - - - 0.000000000000000000008923 99.0
HKD2_k127_8128321_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007632 610.0
HKD2_k127_8128321_1 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 631.0
HKD2_k127_8128321_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000009422 220.0
HKD2_k127_8128321_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000009993 231.0
HKD2_k127_8128321_12 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000005627 179.0
HKD2_k127_8128321_13 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000000000000000000000000000414 144.0
HKD2_k127_8128321_14 Methyltransferase domain - - - 0.00000000000000000000000000000000001719 145.0
HKD2_k127_8128321_15 Protein conserved in bacteria - - - 0.000000000000000000000000000000005086 134.0
HKD2_k127_8128321_16 - - - - 0.000000002386 57.0
HKD2_k127_8128321_2 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 538.0
HKD2_k127_8128321_3 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 521.0
HKD2_k127_8128321_4 Belongs to the GPI family K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 514.0
HKD2_k127_8128321_5 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 486.0
HKD2_k127_8128321_6 Catalyzes a key regulatory step in fatty acid biosynthesis K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 366.0
HKD2_k127_8128321_7 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006485 317.0
HKD2_k127_8128321_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342,K14159 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007509 280.0
HKD2_k127_8128321_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000004147 229.0
HKD2_k127_8135414_0 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 4.431e-246 790.0
HKD2_k127_8135414_1 Aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 4.513e-236 737.0
HKD2_k127_8135414_2 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 615.0
HKD2_k127_8135414_3 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 356.0
HKD2_k127_8135414_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003371 278.0
HKD2_k127_8135414_5 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000006478 175.0
HKD2_k127_8135414_6 - - - - 0.00000000000000000000000000000000000000000002152 174.0
HKD2_k127_8135414_7 - - - - 0.0000000000000000000000000000000000000009679 155.0
HKD2_k127_8135414_8 Glyoxalase-like domain - - - 0.000000000000000000000000000000001814 134.0
HKD2_k127_8158753_0 alcohol dehydrogenase - - - 6.344e-229 719.0
HKD2_k127_8158753_1 Heparinase II/III N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 565.0
HKD2_k127_8158753_2 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 405.0
HKD2_k127_8158753_3 PFAM Glycosyl transferase family 4 K13007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 320.0
HKD2_k127_8158753_4 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 289.0
HKD2_k127_8158753_5 Gram-negative-bacterium-type cell wall biogenesis - GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 - 0.0000000000000000000000000000000000000002413 159.0
HKD2_k127_8208273_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.753e-301 933.0
HKD2_k127_8208273_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 426.0
HKD2_k127_8208273_10 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication K06980 GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - 0.000001436 53.0
HKD2_k127_8208273_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007081 258.0
HKD2_k127_8208273_3 PFAM MucB RseB K03598 - - 0.00000000000000000000000000000000000000000000000000000005349 209.0
HKD2_k127_8208273_4 succinate dehydrogenase K00241 - - 0.0000000000000000000000001448 111.0
HKD2_k127_8208273_5 succinate dehydrogenase, hydrophobic membrane anchor K00242 - - 0.00000000000000000000005974 103.0
HKD2_k127_8208273_6 cell redox homeostasis K00384 - 1.8.1.9 0.0000000000002958 74.0
HKD2_k127_8208273_7 Flavinator of succinate dehydrogenase K09159 GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 - 0.000000000001458 71.0
HKD2_k127_8208273_8 Protein of unknown function (DUF1674) - - - 0.0000002297 59.0
HKD2_k127_8208273_9 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E K03597 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.0000003069 60.0
HKD2_k127_8210947_0 PQQ enzyme repeat K00117 - 1.1.5.2 6.381e-204 653.0
HKD2_k127_8210947_1 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 445.0
HKD2_k127_8210947_10 thiolester hydrolase activity K06889 - - 0.000000000149 71.0
HKD2_k127_8210947_11 SnoaL-like domain - - - 0.000000002081 59.0
HKD2_k127_8210947_12 - K01992 - - 0.00000003783 65.0
HKD2_k127_8210947_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 401.0
HKD2_k127_8210947_3 Sugar (and other) transporter K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 377.0
HKD2_k127_8210947_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000002637 246.0
HKD2_k127_8210947_5 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
HKD2_k127_8210947_6 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000007007 206.0
HKD2_k127_8210947_7 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000000000000000000009536 136.0
HKD2_k127_8210947_8 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000003237 128.0
HKD2_k127_8388744_0 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 510.0
HKD2_k127_8388744_1 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 501.0
HKD2_k127_8388744_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 383.0
HKD2_k127_8388744_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 304.0
HKD2_k127_8388744_4 o-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000001702 216.0
HKD2_k127_8388744_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000004454 69.0
HKD2_k127_8419172_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009716 545.0
HKD2_k127_8419172_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 413.0
HKD2_k127_8419172_10 Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000213 250.0
HKD2_k127_8419172_11 FimV C-terminal K08086 - - 0.00000000000000000000000000000000000000000000000000000000000000005285 254.0
HKD2_k127_8419172_12 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000002728 152.0
HKD2_k127_8419172_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 393.0
HKD2_k127_8419172_3 lysine 2,3-aminomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 349.0
HKD2_k127_8419172_4 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 319.0
HKD2_k127_8419172_5 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 303.0
HKD2_k127_8419172_6 PFAM EAL domain K21025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008916 309.0
HKD2_k127_8419172_7 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007859 284.0
HKD2_k127_8419172_8 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000001106 265.0
HKD2_k127_8419172_9 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000003052 250.0
HKD2_k127_8422975_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 7.674e-219 702.0
HKD2_k127_8422975_1 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 334.0
HKD2_k127_8422975_2 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004674 269.0
HKD2_k127_8422975_3 Sugar (and other) transporter - - - 0.00000000000007101 74.0
HKD2_k127_8520047_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 4.123e-268 844.0
HKD2_k127_8520047_1 DNA topological change K03168 - 5.99.1.2 5.371e-235 752.0
HKD2_k127_8520047_10 PPIC-type PPIASE domain - - - 0.0000000000000000000000000000000000000000001654 170.0
HKD2_k127_8520047_11 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000002572 126.0
HKD2_k127_8520047_12 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000003966 111.0
HKD2_k127_8520047_13 Bacterial extracellular solute-binding protein K22003 - 5.3.3.7 0.0000000000000000000002379 113.0
HKD2_k127_8520047_14 - - - - 0.000007465 55.0
HKD2_k127_8520047_15 Bacterial virulence protein (VirJ) - - - 0.0009541 50.0
HKD2_k127_8520047_2 PQQ-like domain K00117 - 1.1.5.2 7.764e-214 683.0
HKD2_k127_8520047_3 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 526.0
HKD2_k127_8520047_4 Amino acid permease K11735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 501.0
HKD2_k127_8520047_5 Cobalamin-independent synthase, Catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 441.0
HKD2_k127_8520047_6 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 415.0
HKD2_k127_8520047_7 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 323.0
HKD2_k127_8520047_8 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 312.0
HKD2_k127_8520047_9 HupE / UreJ protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001365 299.0
HKD2_k127_8535077_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 2.223e-315 985.0
HKD2_k127_8535077_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - 8.782e-251 789.0
HKD2_k127_8535077_10 Nicotinate phosphoribosyltransferase (NAPRTase) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 505.0
HKD2_k127_8535077_11 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 441.0
HKD2_k127_8535077_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 407.0
HKD2_k127_8535077_13 Histidine kinase K14986 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 313.0
HKD2_k127_8535077_14 PFAM isochorismatase hydrolase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000002735 260.0
HKD2_k127_8535077_15 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000008046 270.0
HKD2_k127_8535077_16 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003747 254.0
HKD2_k127_8535077_17 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003976 242.0
HKD2_k127_8535077_18 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001032 243.0
HKD2_k127_8535077_19 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000002079 249.0
HKD2_k127_8535077_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.265e-244 775.0
HKD2_k127_8535077_20 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000009686 230.0
HKD2_k127_8535077_21 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000002768 219.0
HKD2_k127_8535077_22 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000002219 224.0
HKD2_k127_8535077_23 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000000006693 214.0
HKD2_k127_8535077_24 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000006149 206.0
HKD2_k127_8535077_25 universal stress protein K14055 - - 0.00000000000000000000000000000000000000000000000009986 191.0
HKD2_k127_8535077_26 universal stress protein K14055 - - 0.0000000000000000000000000000000000000000000000001392 189.0
HKD2_k127_8535077_27 Archease protein family (MTH1598/TM1083) - - - 0.000000000000000000000000000000000000000000000002712 180.0
HKD2_k127_8535077_28 Thioredoxin K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000003004 189.0
HKD2_k127_8535077_29 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000000223 160.0
HKD2_k127_8535077_3 Belongs to the peptidase S16 family - - - 1.411e-232 747.0
HKD2_k127_8535077_30 Flavodoxin - - - 0.000000000000000000000000000000000000004547 151.0
HKD2_k127_8535077_31 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000001014 141.0
HKD2_k127_8535077_32 YMGG-like Gly-zipper - - - 0.000000000000000000000000000000009664 134.0
HKD2_k127_8535077_33 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000001638 148.0
HKD2_k127_8535077_34 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000001323 129.0
HKD2_k127_8535077_35 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000000000000000000000006507 128.0
HKD2_k127_8535077_37 Protein of unknown function (DUF3313) - - - 0.00000000000000000000000000001068 128.0
HKD2_k127_8535077_38 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000009062 115.0
HKD2_k127_8535077_39 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000007719 102.0
HKD2_k127_8535077_4 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 1.027e-230 746.0
HKD2_k127_8535077_40 - - - - 0.00000000000000000002847 94.0
HKD2_k127_8535077_41 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000393 87.0
HKD2_k127_8535077_42 long-chain fatty acid transport protein - - - 0.00000000000000008414 90.0
HKD2_k127_8535077_43 Universal stress protein family K14055 - - 0.00000000000000008534 91.0
HKD2_k127_8535077_45 PFAM UspA - - - 0.00000000008702 73.0
HKD2_k127_8535077_46 - - - - 0.0000000004524 64.0
HKD2_k127_8535077_47 - - - - 0.00000002699 63.0
HKD2_k127_8535077_5 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 7.504e-230 726.0
HKD2_k127_8535077_6 Belongs to the RtcB family K14415 - 6.5.1.3 3.084e-216 679.0
HKD2_k127_8535077_7 TonB dependent receptor - - - 9.297e-205 678.0
HKD2_k127_8535077_8 TonB dependent receptor - - - 3.322e-204 674.0
HKD2_k127_8535077_9 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 593.0
HKD2_k127_8542155_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1064.0
HKD2_k127_8542155_1 Concanavalin A-like lectin/glucanases superfamily - - - 1.656e-251 803.0
HKD2_k127_8542155_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 420.0
HKD2_k127_8542155_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 415.0
HKD2_k127_8542155_12 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 365.0
HKD2_k127_8542155_13 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 329.0
HKD2_k127_8542155_14 ABC-type molybdate transport system, permease component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008927 306.0
HKD2_k127_8542155_15 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 303.0
HKD2_k127_8542155_16 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 321.0
HKD2_k127_8542155_17 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001459 265.0
HKD2_k127_8542155_18 COG3103 SH3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001052 252.0
HKD2_k127_8542155_19 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003501 243.0
HKD2_k127_8542155_2 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 4.587e-247 791.0
HKD2_k127_8542155_20 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000172 239.0
HKD2_k127_8542155_21 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000138 222.0
HKD2_k127_8542155_22 XdhC and CoxI family - - - 0.0000000000000000000000000000000000000000000000000000000006426 224.0
HKD2_k127_8542155_23 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000002368 190.0
HKD2_k127_8542155_24 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000001786 196.0
HKD2_k127_8542155_25 Pilin (bacterial filament) K02650,K02655 - - 0.0000000000000000000000000000000000000000001127 166.0
HKD2_k127_8542155_26 thiosulfate sulfurtransferase activity - - - 0.000000000000000000000000000000000000008752 151.0
HKD2_k127_8542155_27 Glutathione peroxidase K02199 - - 0.00000000000000000000000000000000000003266 149.0
HKD2_k127_8542155_28 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000005705 141.0
HKD2_k127_8542155_3 - - - - 4.04e-200 640.0
HKD2_k127_8542155_30 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.000000000000000000003437 106.0
HKD2_k127_8542155_31 Domain of unknown function (DUF4266) - - - 0.00000000000000000001153 100.0
HKD2_k127_8542155_32 BlaR1 peptidase M56 - - - 0.00002085 55.0
HKD2_k127_8542155_33 Tetratricopeptide repeat - - - 0.0000991 54.0
HKD2_k127_8542155_4 belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 499.0
HKD2_k127_8542155_5 PrpF protein K16514 - 5.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 484.0
HKD2_k127_8542155_6 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 463.0
HKD2_k127_8542155_7 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 432.0
HKD2_k127_8542155_8 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 442.0
HKD2_k127_8542155_9 Amidohydrolase K10221 - 3.1.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 417.0
HKD2_k127_8611027_0 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001083 287.0
HKD2_k127_8611027_1 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K13014 GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896 - 0.0000000000000000000000000000000000000000000000000000945 192.0
HKD2_k127_8611027_2 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000002418 181.0
HKD2_k127_8611027_3 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000000000000000000000739 126.0
HKD2_k127_8611027_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000007562 106.0
HKD2_k127_8611027_5 PFAM phosphoesterase, PA-phosphatase related - - - 0.0000000000000003123 92.0
HKD2_k127_8611027_6 Permeases of the drug metabolite transporter (DMT) superfamily K12962 - - 0.0000000000000004211 88.0
HKD2_k127_8611027_7 Domain of unknown function (DUF3444) - - - 0.0000005713 53.0
HKD2_k127_8611027_8 Small Multidrug Resistance protein - - - 0.000009837 57.0
HKD2_k127_8620165_0 UPF0313 protein - - - 0.0 1077.0
HKD2_k127_8620165_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.59e-233 735.0
HKD2_k127_8620165_10 - - - - 0.000000000000000001843 91.0
HKD2_k127_8620165_11 - - - - 0.00000000000007724 79.0
HKD2_k127_8620165_12 - - - - 0.0000000000003052 73.0
HKD2_k127_8620165_13 COG1585 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.0000003951 59.0
HKD2_k127_8620165_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 437.0
HKD2_k127_8620165_3 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 411.0
HKD2_k127_8620165_4 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 313.0
HKD2_k127_8620165_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002802 292.0
HKD2_k127_8620165_6 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000001059 248.0
HKD2_k127_8620165_7 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000002014 233.0
HKD2_k127_8620165_8 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000003338 134.0
HKD2_k127_8620165_9 Helix-turn-helix XRE-family like proteins K07729 - - 0.0000000000000000000005813 99.0
HKD2_k127_8623130_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.55e-304 948.0
HKD2_k127_8623130_1 Carbohydrate phosphorylase K00688,K16153 - 2.4.1.1,2.4.1.11 8.841e-275 871.0
HKD2_k127_8623130_10 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000008252 210.0
HKD2_k127_8623130_11 FMN_bind K19339 - - 0.000000000000000000000000007093 126.0
HKD2_k127_8623130_12 FMN_bind - - - 0.0000000000002885 77.0
HKD2_k127_8623130_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01200,K01214 - 3.2.1.41,3.2.1.68 1.484e-224 752.0
HKD2_k127_8623130_3 Radical SAM superfamily K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 578.0
HKD2_k127_8623130_4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 553.0
HKD2_k127_8623130_5 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 538.0
HKD2_k127_8623130_6 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 472.0
HKD2_k127_8623130_7 ATP-grasp domain K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 370.0
HKD2_k127_8623130_8 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 341.0
HKD2_k127_8623130_9 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009161 336.0
HKD2_k127_8626343_0 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 370.0
HKD2_k127_8626343_1 Glucose sorbosone K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004463 292.0
HKD2_k127_8626343_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000002838 66.0
HKD2_k127_8626343_3 TIGRFAM TonB family protein - - - 0.0000000005377 72.0
HKD2_k127_8638423_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 413.0
HKD2_k127_8638423_1 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000005032 258.0
HKD2_k127_8638423_10 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000003353 60.0
HKD2_k127_8638423_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000911 228.0
HKD2_k127_8638423_3 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000002498 207.0
HKD2_k127_8638423_4 lactoylglutathione lyase activity K03088 - - 0.000000000000000000000000000000000000000000000000007194 192.0
HKD2_k127_8638423_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000001405 174.0
HKD2_k127_8638423_6 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000009143 123.0
HKD2_k127_8638423_7 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000005133 107.0
HKD2_k127_8638423_9 enzyme of the cupin superfamily - - - 0.000000000005332 73.0
HKD2_k127_8647414_0 Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase K03568 - - 6.497e-198 628.0
HKD2_k127_8647414_1 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 519.0
HKD2_k127_8647414_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 390.0
HKD2_k127_8647414_3 Protein of unknown function - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 407.0
HKD2_k127_8647414_4 Type II secretory pathway component ExeA K02450,K12283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 321.0
HKD2_k127_8647414_5 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000132 269.0
HKD2_k127_8647414_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000002001 235.0
HKD2_k127_8647414_7 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000003869 219.0
HKD2_k127_8658153_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 4.331e-195 617.0
HKD2_k127_8658153_1 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 571.0
HKD2_k127_8658153_10 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000005046 128.0
HKD2_k127_8658153_11 Protein of unknown function (DUF2905) - - - 0.00000000000000000000649 94.0
HKD2_k127_8658153_12 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000003198 59.0
HKD2_k127_8658153_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004553 521.0
HKD2_k127_8658153_3 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 512.0
HKD2_k127_8658153_4 Anthranilate synthase component I K01657,K01665 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 509.0
HKD2_k127_8658153_5 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 419.0
HKD2_k127_8658153_6 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 312.0
HKD2_k127_8658153_7 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001251 252.0
HKD2_k127_8658153_8 Tetratricopeptide repeat K03671,K05838 - - 0.000000000000000000000000000000000000000000000000000000004757 212.0
HKD2_k127_8658153_9 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000001454 138.0
HKD2_k127_865870_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 505.0
HKD2_k127_865870_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 368.0
HKD2_k127_865870_2 PhoPQ-activated pathogenicity-related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 311.0
HKD2_k127_865870_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000001287 220.0
HKD2_k127_865870_4 STAS-like domain of unknown function (DUF4325) - - - 0.00000000000000000000000000000000000000000000000000007725 199.0
HKD2_k127_865870_5 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000023 142.0
HKD2_k127_865870_6 SnoaL-like domain - - - 0.0000000000000000000000000003887 118.0
HKD2_k127_865870_7 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000029 120.0
HKD2_k127_865870_8 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.00000008033 55.0
HKD2_k127_8675572_0 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 453.0
HKD2_k127_8675572_1 MFS transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 436.0
HKD2_k127_8675572_10 Glutathione S-transferase K00799 - 2.5.1.18 0.0002699 44.0
HKD2_k127_8675572_2 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 366.0
HKD2_k127_8675572_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 317.0
HKD2_k127_8675572_4 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009135 279.0
HKD2_k127_8675572_5 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000006315 220.0
HKD2_k127_8675572_6 Predicted membrane protein (DUF2214) - - - 0.000000000000000000000000000000000000002665 151.0
HKD2_k127_8675572_7 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000002798 117.0
HKD2_k127_8675572_8 May be involved in recombination K03554 - - 0.000000000000000000001519 110.0
HKD2_k127_8675572_9 lactoylglutathione lyase activity K03088 - - 0.000000000000001012 79.0
HKD2_k127_879752_0 sulphate transporter - - - 1.778e-206 661.0
HKD2_k127_879752_1 leucine-zipper of insertion element IS481 K07497 - - 1.54e-197 621.0
HKD2_k127_879752_10 Cache_2 K02480 - 2.7.13.3 0.00000000000003399 82.0
HKD2_k127_879752_2 Sodium/calcium exchanger protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 513.0
HKD2_k127_879752_3 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 456.0
HKD2_k127_879752_4 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 443.0
HKD2_k127_879752_5 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 364.0
HKD2_k127_879752_6 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003033 282.0
HKD2_k127_879752_8 Protein of unknown function (DUF3302) - - - 0.000000000000000000000000000002283 128.0
HKD2_k127_879752_9 Universal stress protein K06149 - - 0.000000000000000000000000002447 117.0
HKD2_k127_8814102_0 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 9.499e-256 803.0
HKD2_k127_8814102_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 5.618e-215 692.0
HKD2_k127_8814102_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009151 427.0
HKD2_k127_8814102_11 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 362.0
HKD2_k127_8814102_12 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 328.0
HKD2_k127_8814102_13 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 316.0
HKD2_k127_8814102_14 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 304.0
HKD2_k127_8814102_15 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000281 288.0
HKD2_k127_8814102_16 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002943 275.0
HKD2_k127_8814102_17 Glycosyl Transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008131 256.0
HKD2_k127_8814102_18 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001058 253.0
HKD2_k127_8814102_19 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000005551 235.0
HKD2_k127_8814102_2 PFAM monooxygenase FAD-binding K20940 - 1.14.13.218 3.978e-209 660.0
HKD2_k127_8814102_20 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000005528 225.0
HKD2_k127_8814102_21 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000002757 231.0
HKD2_k127_8814102_22 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000002408 180.0
HKD2_k127_8814102_23 Hydrolase - - - 0.0000000000000000000000000000000000000005363 158.0
HKD2_k127_8814102_24 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000022 138.0
HKD2_k127_8814102_25 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000008642 109.0
HKD2_k127_8814102_26 protein conserved in bacteria K09937 - - 0.000000001415 61.0
HKD2_k127_8814102_27 Site-specific recombinase, DNA invertase Pin - - - 0.0000355 51.0
HKD2_k127_8814102_28 FeoA K04758 - - 0.000104 48.0
HKD2_k127_8814102_29 - - - - 0.0004091 51.0
HKD2_k127_8814102_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 567.0
HKD2_k127_8814102_4 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 557.0
HKD2_k127_8814102_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008826 578.0
HKD2_k127_8814102_6 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 566.0
HKD2_k127_8814102_7 Asparagine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 463.0
HKD2_k127_8814102_8 NAD dependent epimerase/dehydratase family K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 450.0
HKD2_k127_8814102_9 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 447.0
HKD2_k127_8879697_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 406.0
HKD2_k127_8879697_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 322.0
HKD2_k127_8879697_10 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000004934 161.0
HKD2_k127_8879697_11 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000003946 153.0
HKD2_k127_8879697_12 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000008888 134.0
HKD2_k127_8879697_13 GntR family transcriptional regulator K07979 - - 0.000000000000000000000000000002501 124.0
HKD2_k127_8879697_14 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K03088 - - 0.00000000000000000000000000000583 126.0
HKD2_k127_8879697_15 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000127 119.0
HKD2_k127_8879697_16 AntiSigma factor - - - 0.00000000000002635 82.0
HKD2_k127_8879697_17 COG0457 FOG TPR repeat - - - 0.00000000002746 76.0
HKD2_k127_8879697_2 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 315.0
HKD2_k127_8879697_3 bacteriocin export ABC transporter, lactococcin 972 group K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 293.0
HKD2_k127_8879697_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001503 259.0
HKD2_k127_8879697_5 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000005146 247.0
HKD2_k127_8879697_6 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000002511 231.0
HKD2_k127_8879697_7 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000002243 195.0
HKD2_k127_8879697_8 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000003354 168.0
HKD2_k127_8879697_9 methyltransferase - - - 0.00000000000000000000000000000000000000002034 167.0
HKD2_k127_8899293_0 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008916 378.0
HKD2_k127_8899293_1 DNA topological change - - - 0.0000000000000000000000000000000000000000000000005606 181.0
HKD2_k127_8899293_2 Type III secretion system lipoprotein chaperone (YscW) K09914 - - 0.00000003465 61.0
HKD2_k127_8943749_0 L-2-hydroxyglutarate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 411.0
HKD2_k127_8943749_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 345.0
HKD2_k127_8943749_11 Beta-lactamase K18988 - 3.4.16.4 0.00000002055 63.0
HKD2_k127_8943749_2 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007283 304.0
HKD2_k127_8943749_3 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 291.0
HKD2_k127_8943749_4 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000004923 206.0
HKD2_k127_8943749_5 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000003005 188.0
HKD2_k127_8943749_6 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000371 161.0
HKD2_k127_8943749_7 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000000000000000000000000004473 155.0
HKD2_k127_8943749_8 - - - - 0.0000000000000000000000000000001005 128.0
HKD2_k127_8943749_9 RNA-metabolising metallo-beta-lactamase K07576 - - 0.0000000000000003125 78.0
HKD2_k127_8951154_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1533.0
HKD2_k127_8951154_1 Hydroxymethylglutaryl-coenzyme A reductase K00054 - 1.1.1.88 9.607e-307 973.0
HKD2_k127_8951154_10 GHMP kinases N terminal domain K01597 - 4.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 381.0
HKD2_k127_8951154_11 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007633 361.0
HKD2_k127_8951154_12 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 295.0
HKD2_k127_8951154_13 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 297.0
HKD2_k127_8951154_14 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006128 283.0
HKD2_k127_8951154_15 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002829 263.0
HKD2_k127_8951154_16 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000011 224.0
HKD2_k127_8951154_17 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000007339 222.0
HKD2_k127_8951154_18 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000004713 218.0
HKD2_k127_8951154_19 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.00000000000000000000000000000000000000000000000000000000001568 214.0
HKD2_k127_8951154_2 DNA ligase (ATP) activity K01971 - 6.5.1.1 2.461e-270 857.0
HKD2_k127_8951154_20 TPR repeat - - - 0.00000000000000000000000000000000000000000000000007242 190.0
HKD2_k127_8951154_21 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000004063 201.0
HKD2_k127_8951154_22 GHMP kinases N terminal domain K00938 - 2.7.4.2 0.00000000000000000000000000000000000000000001789 174.0
HKD2_k127_8951154_23 MlaC protein K07323 - - 0.000000000000000000000000001661 121.0
HKD2_k127_8951154_24 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000886 119.0
HKD2_k127_8951154_25 Adenylate cyclase - - - 0.000000000000000000000001013 115.0
HKD2_k127_8951154_26 Transcriptional regulator K07729 - - 0.000000000000000000003445 96.0
HKD2_k127_8951154_27 Histidine kinase K03407 - 2.7.13.3 0.00000007973 66.0
HKD2_k127_8951154_28 Phosphorylase superfamily K01243 - 3.2.2.9 0.000002317 58.0
HKD2_k127_8951154_29 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0001033 55.0
HKD2_k127_8951154_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00124 - - 1.823e-233 732.0
HKD2_k127_8951154_4 Domain of unknown function (DUF3463) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 591.0
HKD2_k127_8951154_5 synthase K01641,K15311 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009605 529.0
HKD2_k127_8951154_6 Exporters of the RND superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 487.0
HKD2_k127_8951154_7 L-lactate dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 435.0
HKD2_k127_8951154_8 Squalene phytoene synthase K00801 - 2.5.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 400.0
HKD2_k127_8951154_9 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 400.0
HKD2_k127_9080419_0 AcrB/AcrD/AcrF family K15726 - - 3.96e-208 657.0
HKD2_k127_9080419_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 591.0
HKD2_k127_9080419_10 - - - - 0.0000000000006482 79.0
HKD2_k127_9080419_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 430.0
HKD2_k127_9080419_3 signal transduction histidine kinase K07644,K07649 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000749 305.0
HKD2_k127_9080419_4 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009381 292.0
HKD2_k127_9080419_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003163 261.0
HKD2_k127_9080419_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000008494 212.0
HKD2_k127_9080419_7 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000392 209.0
HKD2_k127_9080419_8 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000001913 172.0
HKD2_k127_9080419_9 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000002051 163.0
HKD2_k127_9107074_1 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006546 465.0
HKD2_k127_9107074_2 Enoyl-CoA hydratase/isomerase K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.0000000000000000000006954 104.0
HKD2_k127_9107074_3 SnoaL-like domain - - - 0.00000000000004541 84.0
HKD2_k127_9107074_4 Carboxymuconolactone decarboxylase family - - - 0.000000000005028 68.0
HKD2_k127_9107074_5 NMT1-like family - - - 0.000000000006979 68.0
HKD2_k127_9136061_0 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 3.829e-250 809.0
HKD2_k127_9136061_1 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 425.0
HKD2_k127_9136061_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 346.0
HKD2_k127_9136061_3 Preprotein translocase subunit TatD K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 312.0
HKD2_k127_9136061_4 NERD domain protein - - - 0.00000000000000000004595 97.0
HKD2_k127_9136061_5 peptidyl-tyrosine sulfation - - - 0.00000942 57.0
HKD2_k127_9175311_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1206.0
HKD2_k127_9175311_1 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 1.543e-199 635.0
HKD2_k127_9175311_10 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000009562 198.0
HKD2_k127_9175311_11 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.0000000000000000000000000000000000000000000003542 174.0
HKD2_k127_9175311_12 Type II secretion system protein C - - - 0.0000000000000000000000001147 114.0
HKD2_k127_9175311_13 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000006518 98.0
HKD2_k127_9175311_14 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000009006 90.0
HKD2_k127_9175311_2 secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 493.0
HKD2_k127_9175311_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 429.0
HKD2_k127_9175311_4 General secretion pathway protein K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 420.0
HKD2_k127_9175311_5 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 379.0
HKD2_k127_9175311_6 ErfK YbiS YcfS YnhG family protein K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 319.0
HKD2_k127_9175311_7 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 298.0
HKD2_k127_9175311_8 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000002869 263.0
HKD2_k127_9175311_9 Responsible for synthesis of pseudouridine from uracil K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000008128 241.0
HKD2_k127_9180147_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 8.703e-206 653.0
HKD2_k127_9180147_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 430.0
HKD2_k127_9180147_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000004935 181.0
HKD2_k127_9180147_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000003142 127.0
HKD2_k127_9189099_0 Type II secretion system (T2SS), protein K K02460 - - 0.00000000000000000000000000000000000000000000000000000000003628 226.0
HKD2_k127_9189099_1 General secretion pathway protein K02456 - - 0.0000000000000000000000000000000000000000000002118 174.0
HKD2_k127_9189099_10 Type II secretion system, protein N K02463 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000008099 59.0
HKD2_k127_9189099_2 UvrD-like helicase C-terminal domain - - - 0.00000000000000000000000000000000000000545 155.0
HKD2_k127_9189099_3 Type II secretion system (T2SS), protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000000000000000000000000001448 136.0
HKD2_k127_9189099_4 Rhomboid family - - - 0.0000000000000000000000000001075 123.0
HKD2_k127_9189099_5 Type II transport protein GspH K02457 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000000000005104 102.0
HKD2_k127_9189099_6 TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.0000000004357 70.0
HKD2_k127_9189099_7 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.00000001018 67.0
HKD2_k127_9189099_8 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02462 - - 0.00000001632 67.0
HKD2_k127_9189099_9 COG2165 Type II secretory pathway, pseudopilin PulG K02458 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000001472 59.0
HKD2_k127_9237775_0 Ribonucleoside-diphosphate reductase large - - - 1.734e-239 747.0
HKD2_k127_9237775_1 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.301e-224 714.0
HKD2_k127_9237775_10 - - - - 0.00000000000000000000000000000000000000000000000000000002154 207.0
HKD2_k127_9237775_11 HDOD domain - - - 0.0000000000000000000000000000000000000000000000000009238 196.0
HKD2_k127_9237775_12 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000004904 163.0
HKD2_k127_9237775_13 pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000000000448 148.0
HKD2_k127_9237775_14 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000003603 140.0
HKD2_k127_9237775_15 Transcriptional regulator K07727 - - 0.00000000000000000000000001805 111.0
HKD2_k127_9237775_16 Putative diguanylate phosphodiesterase - - - 0.00000000000000000002333 96.0
HKD2_k127_9237775_17 Protein of unknown function (DUF2975) - - - 0.0000000000000003139 85.0
HKD2_k127_9237775_18 Polypeptide-transport-associated domain protein ShlB-type - - - 0.00000000004825 72.0
HKD2_k127_9237775_19 diguanylate cyclase - - - 0.0000003449 61.0
HKD2_k127_9237775_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 595.0
HKD2_k127_9237775_3 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 429.0
HKD2_k127_9237775_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 416.0
HKD2_k127_9237775_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 408.0
HKD2_k127_9237775_6 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 391.0
HKD2_k127_9237775_7 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 363.0
HKD2_k127_9237775_8 Double sensory domain of two-component sensor kinase - - - 0.0000000000000000000000000000000000000000000000000000000000004185 226.0
HKD2_k127_9237775_9 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000008179 224.0
HKD2_k127_9269208_0 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 481.0
HKD2_k127_9269208_1 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 379.0
HKD2_k127_9269208_10 Universal stress protein family - - - 0.000000000000007973 86.0
HKD2_k127_9269208_11 - - - - 0.000000000003498 78.0
HKD2_k127_9269208_2 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 325.0
HKD2_k127_9269208_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 331.0
HKD2_k127_9269208_4 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000007524 266.0
HKD2_k127_9269208_5 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.000000000000000000000000000000000000001721 158.0
HKD2_k127_9269208_6 negative regulation of transcription, DNA-templated - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000003095 141.0
HKD2_k127_9269208_7 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000933 114.0
HKD2_k127_9269208_8 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000001042 104.0
HKD2_k127_9269208_9 sequence-specific DNA binding - - - 0.00000000000000002013 92.0
HKD2_k127_930307_0 DNA topological change - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 526.0
HKD2_k127_930307_1 Protein of unknown function (DUF1552) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 365.0
HKD2_k127_930307_2 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000005461 195.0
HKD2_k127_930307_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000004583 152.0
HKD2_k127_930307_5 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000000001674 119.0
HKD2_k127_930307_6 - - - - 0.0000000000000000000000005508 115.0
HKD2_k127_930307_7 - - - - 0.0000000000002741 82.0
HKD2_k127_930307_8 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000197 57.0
HKD2_k127_9396247_0 COG1131 ABC-type multidrug transport system, ATPase component K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 403.0
HKD2_k127_9396247_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 382.0
HKD2_k127_9396247_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 301.0
HKD2_k127_9396247_3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 293.0
HKD2_k127_9396247_4 Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001057 257.0
HKD2_k127_9396247_5 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005588 234.0
HKD2_k127_9396247_6 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000001051 183.0
HKD2_k127_9396247_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000002192 113.0
HKD2_k127_9396247_8 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000000001019 101.0
HKD2_k127_9396247_9 Type II secretion system protein B K02451 - - 0.000001518 56.0
HKD2_k127_9427754_0 ATP-dependent helicase K03579 - 3.6.4.13 1.928e-259 825.0
HKD2_k127_9427754_1 LVIVD repeat - - - 1.047e-209 664.0
HKD2_k127_9427754_10 Rossmann-like domain K06988 - 1.5.1.40 0.0000000000000000000000000001651 125.0
HKD2_k127_9427754_11 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.0000000000000000000000001224 124.0
HKD2_k127_9427754_12 Protein of unknown function (DUF3175) - - - 0.00000000000000000000004275 114.0
HKD2_k127_9427754_13 - - - - 0.0000000000000000000002725 100.0
HKD2_k127_9427754_14 - - - - 0.000000000000000002226 87.0
HKD2_k127_9427754_15 - - - - 0.000000000000000008232 87.0
HKD2_k127_9427754_16 membrane - - - 0.00000000000000002177 85.0
HKD2_k127_9427754_17 - - - - 0.00000000003309 74.0
HKD2_k127_9427754_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009989 623.0
HKD2_k127_9427754_3 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 567.0
HKD2_k127_9427754_4 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 456.0
HKD2_k127_9427754_5 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 349.0
HKD2_k127_9427754_6 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 347.0
HKD2_k127_9427754_7 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005217 258.0
HKD2_k127_9427754_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000005009 231.0
HKD2_k127_9427754_9 Cupin domain - - - 0.000000000000000000000000000000002163 138.0
HKD2_k127_9453513_0 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 2.177e-217 689.0
HKD2_k127_9453513_1 COG0277 FAD FMN-containing dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 366.0
HKD2_k127_9453513_2 helix_turn_helix, mercury resistance K19591 - - 0.00000000000000000000000000000000000000004039 157.0
HKD2_k127_9453513_3 Thioesterase superfamily K19222 - 3.1.2.28 0.0000000000000000000000000000000000000002478 153.0
HKD2_k127_9454397_0 acyl-CoA dehydrogenase K00252 - 1.3.8.6 8.604e-205 652.0
HKD2_k127_9454397_1 regulation of methylation-dependent chromatin silencing K07454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 399.0
HKD2_k127_9454397_2 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008686 385.0
HKD2_k127_9454397_4 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003843 274.0
HKD2_k127_9454397_5 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000008969 188.0
HKD2_k127_9454397_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001537 173.0
HKD2_k127_9454397_7 diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family - - - 0.00000000000000000000000000000000000000006604 155.0
HKD2_k127_9454397_8 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000001817 149.0
HKD2_k127_9467932_0 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 564.0
HKD2_k127_9467932_1 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 477.0
HKD2_k127_9467932_2 PQQ-like domain K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008626 415.0
HKD2_k127_9467932_3 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 364.0
HKD2_k127_9467932_4 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 313.0
HKD2_k127_9467932_5 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000007674 220.0
HKD2_k127_9544676_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.129e-224 718.0
HKD2_k127_9544676_1 SbmA/BacA-like family - - - 1.089e-217 691.0
HKD2_k127_9544676_10 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000172 289.0
HKD2_k127_9544676_11 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001095 256.0
HKD2_k127_9544676_12 Melibiase K07407 - 3.2.1.22 0.00000000000000000000000000000000000000000000000000000000000003432 246.0
HKD2_k127_9544676_13 Cupin - - - 0.0000000000000000000000000000000000000000000000000004757 188.0
HKD2_k127_9544676_14 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000001675 185.0
HKD2_k127_9544676_15 - - - - 0.000000000000000008516 89.0
HKD2_k127_9544676_2 SbmA/BacA-like family - - - 1.224e-211 680.0
HKD2_k127_9544676_3 Putative glucoamylase - - - 1.531e-210 663.0
HKD2_k127_9544676_4 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 648.0
HKD2_k127_9544676_5 Glycosyl hydrolases family 15 K01178 - 3.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 511.0
HKD2_k127_9544676_6 Protein of unknown function (DUF1587) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 466.0
HKD2_k127_9544676_7 Protein of unknown function (DUF1552) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004826 437.0
HKD2_k127_9544676_8 ankyrin repeat K15503 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 402.0
HKD2_k127_9544676_9 Belongs to the glycosyl hydrolase 3 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 345.0
HKD2_k127_9556482_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 1.971e-217 698.0
HKD2_k127_9556482_1 alginic acid biosynthetic process K01729 - 4.2.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 608.0
HKD2_k127_9556482_10 Conserved TM helix - - - 0.0003099 52.0
HKD2_k127_9556482_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 469.0
HKD2_k127_9556482_3 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 401.0
HKD2_k127_9556482_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 331.0
HKD2_k127_9556482_5 Serine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000757 305.0
HKD2_k127_9556482_6 of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003347 245.0
HKD2_k127_9556482_7 involved in outer membrane biogenesis K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000003438 249.0
HKD2_k127_9556482_8 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000000000005877 216.0
HKD2_k127_9556482_9 MgtE intracellular N domain - - - 0.000000000000000000000001033 120.0
HKD2_k127_9569639_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 502.0
HKD2_k127_9569639_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009315 486.0
HKD2_k127_9569639_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 411.0
HKD2_k127_9569639_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 310.0
HKD2_k127_9569639_4 PFAM Short-chain dehydrogenase reductase SDR K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 291.0
HKD2_k127_9569639_5 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000004877 156.0
HKD2_k127_9569639_6 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000837 132.0
HKD2_k127_9569639_7 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000001121 98.0
HKD2_k127_9569639_8 aminopeptidase - - - 0.00000002091 59.0
HKD2_k127_9640608_0 ABC transporter K06147,K18893 - - 2.616e-246 776.0
HKD2_k127_9640608_1 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 492.0
HKD2_k127_9640608_2 Trypsin-like peptidase domain K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 438.0
HKD2_k127_9640608_3 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 393.0
HKD2_k127_9640608_4 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 341.0
HKD2_k127_9640608_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000155 250.0
HKD2_k127_9640608_6 Thioesterase domain - - - 0.00000000000000000000000000000000000000000000000000000004039 211.0
HKD2_k127_9640608_7 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000001551 184.0
HKD2_k127_9640608_8 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000001327 161.0
HKD2_k127_9640608_9 Phosphopantetheine attachment site - - - 0.00000000008938 66.0
HKD2_k127_9642483_0 Luciferase-like monooxygenase - - - 5.033e-195 612.0
HKD2_k127_9642483_1 carboxylic ester hydrolase activity K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 376.0
HKD2_k127_9642483_10 - - - - 0.0000005199 62.0
HKD2_k127_9642483_11 Glyoxalase-like domain - - - 0.000003562 59.0
HKD2_k127_9642483_12 TonB dependent receptor - - - 0.000005543 54.0
HKD2_k127_9642483_2 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 340.0
HKD2_k127_9642483_3 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 337.0
HKD2_k127_9642483_4 ankyrin repeat K15503 - - 0.0000000000000000000000000000000000000000000000000000000000009085 233.0
HKD2_k127_9642483_5 NUDIX domain - - - 0.00000000000000000000000000000000000000000000009507 173.0
HKD2_k127_9642483_6 Histidine kinase K01120,K07315 - 3.1.3.3,3.1.4.17 0.0000000000000000000000000000000000000000000002341 188.0
HKD2_k127_9642483_7 Protein of unknown function (DUF3237) - - - 0.0000000000000000000000000000001001 132.0
HKD2_k127_9642483_8 DNA topological change K03168 - 5.99.1.2 0.000000000000000000000000000002451 124.0
HKD2_k127_9642483_9 Alpha beta hydrolase fold-3 domain protein - - - 0.00000000000000000000000000001473 123.0
HKD2_k127_9663235_0 PFAM Orn DAP Arg decarboxylase 2 K01585 - 4.1.1.19 1.191e-220 702.0
HKD2_k127_9663235_1 PFAM deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 540.0
HKD2_k127_9663235_10 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000016 156.0
HKD2_k127_9663235_11 - - - - 0.0000000000000000000000000000001039 139.0
HKD2_k127_9663235_12 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000003225 117.0
HKD2_k127_9663235_13 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000432 91.0
HKD2_k127_9663235_14 Subtilase family - - - 0.0000001149 64.0
HKD2_k127_9663235_2 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 514.0
HKD2_k127_9663235_3 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 426.0
HKD2_k127_9663235_4 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006382 413.0
HKD2_k127_9663235_5 Glutamate-cysteine ligase family 2(GCS2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 406.0
HKD2_k127_9663235_6 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 365.0
HKD2_k127_9663235_7 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 342.0
HKD2_k127_9663235_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 332.0
HKD2_k127_9663235_9 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004567 274.0
HKD2_k127_971405_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000728 325.0
HKD2_k127_971405_1 Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005835 252.0
HKD2_k127_971405_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000003642 224.0
HKD2_k127_971405_3 Peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000182 147.0
HKD2_k127_971405_4 RNA-binding - - - 0.0000000000000000000000000000001226 125.0
HKD2_k127_971405_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000001914 79.0
HKD2_k127_971405_6 Protein of unknown function (DUF3012) - - - 0.000000000000893 72.0
HKD2_k127_971405_7 - - - - 0.0000044 55.0
HKD2_k127_971405_8 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00008576 51.0
HKD2_k127_9741275_0 TonB dependent receptor K02014 - - 3.155e-279 879.0
HKD2_k127_9741275_1 ABC transporter transmembrane region K06147,K11085 - - 3.522e-200 640.0
HKD2_k127_9741275_10 Cytochrome C oxidase, cbb3-type, subunit III K08738 - - 0.000000000000000000000000000000000000000000000000000000915 198.0
HKD2_k127_9741275_11 deacetylase K06986 - - 0.00000000000000000000000000000000000000000000000000007933 199.0
HKD2_k127_9741275_12 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000002441 146.0
HKD2_k127_9741275_14 RNA recognition motif - - - 0.00000000000000000000000000000008123 126.0
HKD2_k127_9741275_15 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000004251 122.0
HKD2_k127_9741275_16 - - - - 0.000000000000000000000000001191 126.0
HKD2_k127_9741275_17 - - - - 0.00000000000000000000000001744 115.0
HKD2_k127_9741275_18 - - - - 0.00000000000000000000005081 115.0
HKD2_k127_9741275_19 YCII-related domain - - - 0.00000000000000000000005296 105.0
HKD2_k127_9741275_2 Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 503.0
HKD2_k127_9741275_20 - - - - 0.000000000000000000001885 104.0
HKD2_k127_9741275_23 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0004353 44.0
HKD2_k127_9741275_3 metallo-beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 416.0
HKD2_k127_9741275_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 346.0
HKD2_k127_9741275_5 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 338.0
HKD2_k127_9741275_6 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002062 259.0
HKD2_k127_9741275_7 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009476 250.0
HKD2_k127_9741275_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000009075 226.0
HKD2_k127_9741275_9 Putative member of DMT superfamily (DUF486) K09922 - - 0.0000000000000000000000000000000000000000000000000000002706 198.0
HKD2_k127_9770500_0 Pyrrolo-quinoline quinone K00114 - 1.1.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 509.0
HKD2_k127_9770500_1 transport, permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 353.0
HKD2_k127_9770500_2 - - - - 0.00000000000000000000000000000000000000000000000003248 192.0
HKD2_k127_9770500_3 TonB dependent receptor K02014 - - 0.000000000000000000000000846 112.0
HKD2_k127_9800072_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 464.0
HKD2_k127_9800072_1 Splits dipeptides with a prolyl residue in the C- terminal position K01271 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004377 271.0
HKD2_k127_9800072_2 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030,K10001 - - 0.000000000000000000000000000000000000000000000000000000000003956 219.0
HKD2_k127_9800072_3 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000001418 186.0
HKD2_k127_9800072_4 methyltransferase activity - - - 0.00000000000000000000000000006093 123.0
HKD2_k127_9800072_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000001485 115.0
HKD2_k127_9800072_6 RNA recognition motif - - - 0.0000000000000000000000001322 108.0
HKD2_k127_9800072_7 protein kinase activity - - - 0.0000000000000000000002018 108.0
HKD2_k127_9800072_8 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.0000000000000006512 84.0
HKD2_k127_9800072_9 Pfam:RRM_6 - - - 0.00003278 52.0
HKD2_k127_9819584_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1105.0
HKD2_k127_9819584_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 7.935e-278 869.0
HKD2_k127_9819584_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 409.0
HKD2_k127_9819584_11 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 373.0
HKD2_k127_9819584_12 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 340.0
HKD2_k127_9819584_13 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 333.0
HKD2_k127_9819584_14 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001866 295.0
HKD2_k127_9819584_15 abc transporter atp-binding protein K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000009377 274.0
HKD2_k127_9819584_16 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000001491 257.0
HKD2_k127_9819584_17 COG1668 ABC-type Na efflux pump, permease component K09696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002862 271.0
HKD2_k127_9819584_18 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000003142 247.0
HKD2_k127_9819584_19 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000001627 242.0
HKD2_k127_9819584_2 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 6.921e-238 742.0
HKD2_k127_9819584_20 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.00000000000000000000000000000000000000000000000000000001209 211.0
HKD2_k127_9819584_21 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000001915 183.0
HKD2_k127_9819584_22 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000001679 144.0
HKD2_k127_9819584_23 ABC-type dipeptide oligopeptide nickel transport systems, permease components K15581 - - 0.00000000000000000000000000000000002817 140.0
HKD2_k127_9819584_24 Sulfurtransferase - - - 0.000000000000000000000000005799 116.0
HKD2_k127_9819584_25 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000001353 113.0
HKD2_k127_9819584_26 diguanylate cyclase - - - 0.000000000000000000002579 102.0
HKD2_k127_9819584_27 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000001579 97.0
HKD2_k127_9819584_28 Domain of unknown function (DUF4124) - - - 0.000000000000000001931 93.0
HKD2_k127_9819584_29 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000003057 80.0
HKD2_k127_9819584_3 Belongs to the class-II aminoacyl-tRNA synthetase family K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 8.055e-208 658.0
HKD2_k127_9819584_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 607.0
HKD2_k127_9819584_5 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 569.0
HKD2_k127_9819584_6 Bacterial regulatory protein, Fis family K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 565.0
HKD2_k127_9819584_7 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 476.0
HKD2_k127_9819584_8 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 449.0
HKD2_k127_9819584_9 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 420.0
HKD2_k127_9879647_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1013.0
HKD2_k127_9879647_1 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 304.0
HKD2_k127_9879647_2 Belongs to the BI1 family K06890,K19416 - - 0.000000000000000000000000000000000000000000000000000000027 209.0
HKD2_k127_9879647_4 Predicted methyltransferase regulatory domain - - - 0.000000001135 67.0
HKD2_k127_9886512_0 Binding-protein-dependent transport systems inner membrane component K02050 - - 1.657e-219 695.0
HKD2_k127_9886512_1 ABC transporter K02049 - - 4.248e-198 626.0
HKD2_k127_9886512_10 COG1716 FOG FHA domain - - - 0.0001033 55.0
HKD2_k127_9886512_2 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 508.0
HKD2_k127_9886512_3 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 377.0
HKD2_k127_9886512_4 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 324.0
HKD2_k127_9886512_5 Secreted protein, containing von Willebrand factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 295.0
HKD2_k127_9886512_6 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197,6.3.3.3 0.000000000000000000000000000000000000000000000000000006486 199.0
HKD2_k127_9886512_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000001392 197.0
HKD2_k127_9886512_8 - - - - 0.0000000000000000000000003138 122.0
HKD2_k127_9886512_9 OmpA family - - - 0.000000000000000002275 95.0
HKD2_k127_989989_0 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 518.0
HKD2_k127_989989_1 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 361.0
HKD2_k127_989989_2 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007816 278.0
HKD2_k127_989989_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000008711 217.0
HKD2_k127_9916750_0 Glycosyl transferase family group 2 K03669 GO:0005575,GO:0016020 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005634 603.0
HKD2_k127_9916750_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 479.0
HKD2_k127_9916750_2 UPF0056 membrane protein - - - 0.000000000000000000000000000000000000000001285 163.0
HKD2_k127_9916750_3 Exopolysaccharide synthesis, ExoD - - - 0.00000000000000000000000000000000000000001024 161.0
HKD2_k127_9916750_4 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000001392 154.0
HKD2_k127_9916750_6 Protein of unknown function (DUF2845) - - - 0.0007658 47.0