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Overview

ID MAG01831
Name HKD2_bin.96
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Reyranellales
Family Reyranellaceae
Genus Reyranella
Species
Assembly information
Completeness (%) 94.01
Contamination (%) 2.85
GC content (%) 67.0
N50 (bp) 30,757
Genome size (bp) 5,633,274

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes5211

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10053065_0 Binding-protein-dependent transport system inner membrane component K02011 - - 6.221e-260 812.0
HKD2_k127_10053065_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 1.088e-218 684.0
HKD2_k127_10053065_10 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000007946 136.0
HKD2_k127_10053065_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 549.0
HKD2_k127_10053065_3 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 542.0
HKD2_k127_10053065_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 486.0
HKD2_k127_10053065_5 TOBE domain K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 439.0
HKD2_k127_10053065_6 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 355.0
HKD2_k127_10053065_7 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 348.0
HKD2_k127_10053065_8 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 314.0
HKD2_k127_10053065_9 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000000000000000004489 223.0
HKD2_k127_10110606_0 AMP-binding enzyme C-terminal domain K00666,K20034 - 6.2.1.44 0.0 1030.0
HKD2_k127_10110606_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 1.837e-208 651.0
HKD2_k127_10110606_2 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 516.0
HKD2_k127_10110606_3 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 481.0
HKD2_k127_10110606_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 450.0
HKD2_k127_10110606_5 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001226 246.0
HKD2_k127_10159716_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0 1171.0
HKD2_k127_10159716_1 COG2015, Alkyl sulfatase and related hydrolases - - - 0.0 1141.0
HKD2_k127_10159716_10 Major Facilitator Superfamily - - - 6.272e-214 668.0
HKD2_k127_10159716_11 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 1.383e-212 663.0
HKD2_k127_10159716_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 1.289e-209 678.0
HKD2_k127_10159716_13 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 559.0
HKD2_k127_10159716_14 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007439 561.0
HKD2_k127_10159716_15 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 561.0
HKD2_k127_10159716_16 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 548.0
HKD2_k127_10159716_17 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 540.0
HKD2_k127_10159716_18 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 514.0
HKD2_k127_10159716_19 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 511.0
HKD2_k127_10159716_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.0 1012.0
HKD2_k127_10159716_20 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 511.0
HKD2_k127_10159716_21 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 448.0
HKD2_k127_10159716_22 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 455.0
HKD2_k127_10159716_23 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 436.0
HKD2_k127_10159716_24 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 436.0
HKD2_k127_10159716_25 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 435.0
HKD2_k127_10159716_26 PFAM Deoxyribonuclease II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 400.0
HKD2_k127_10159716_27 hydrolase (HAD superfamily) K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 388.0
HKD2_k127_10159716_28 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 388.0
HKD2_k127_10159716_29 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 399.0
HKD2_k127_10159716_3 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 4.944e-309 949.0
HKD2_k127_10159716_30 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 381.0
HKD2_k127_10159716_31 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 325.0
HKD2_k127_10159716_32 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 291.0
HKD2_k127_10159716_33 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008136 261.0
HKD2_k127_10159716_34 ChrR Cupin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001858 258.0
HKD2_k127_10159716_35 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000001701 218.0
HKD2_k127_10159716_36 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000000000000000000000000000000006345 206.0
HKD2_k127_10159716_37 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000001367 207.0
HKD2_k127_10159716_38 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000000000000007384 177.0
HKD2_k127_10159716_39 IMP dehydrogenase activity - - - 0.000000000000000000000000000000000000000000346 168.0
HKD2_k127_10159716_4 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.604e-306 958.0
HKD2_k127_10159716_40 Universal stress protein family - - - 0.000000000000000000000000000000000000000002782 161.0
HKD2_k127_10159716_41 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000003824 164.0
HKD2_k127_10159716_42 Ndr family K14727 - 3.1.1.24,4.1.1.44 0.0000000000000000000000000004904 123.0
HKD2_k127_10159716_43 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000002801 104.0
HKD2_k127_10159716_44 Phosphopantetheine attachment site - - - 0.0000000000000000000002307 100.0
HKD2_k127_10159716_45 - - - - 0.00000000008636 72.0
HKD2_k127_10159716_46 DHHA2 domain protein K15986 - 3.6.1.1 0.00005068 54.0
HKD2_k127_10159716_5 E1-E2 ATPase K01535 - 3.6.3.6 9.996e-299 945.0
HKD2_k127_10159716_6 ABC transporter K02471 - - 6.631e-269 837.0
HKD2_k127_10159716_7 Receptor family ligand binding region - - - 1.425e-242 755.0
HKD2_k127_10159716_8 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.725e-218 690.0
HKD2_k127_10159716_9 COG1960 Acyl-CoA dehydrogenases - - - 4.141e-218 680.0
HKD2_k127_1042752_0 Autotransporter beta-domain - - - 6.173e-303 978.0
HKD2_k127_1042752_1 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 598.0
HKD2_k127_1042752_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 519.0
HKD2_k127_1042752_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 456.0
HKD2_k127_1042752_4 Phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 470.0
HKD2_k127_1061685_0 secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 605.0
HKD2_k127_1061685_1 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 417.0
HKD2_k127_1061685_10 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000003063 130.0
HKD2_k127_1061685_11 Tetratricopeptide repeat - - - 0.0000000000000000000000002999 115.0
HKD2_k127_1061685_14 Type IV leader peptidase family - - - 0.00000000187 66.0
HKD2_k127_1061685_15 TadE-like protein - - - 0.00001073 53.0
HKD2_k127_1061685_16 PFAM TadE family protein - - - 0.000314 51.0
HKD2_k127_1061685_17 Pilus assembly protein CpaD K02281 - - 0.0006129 51.0
HKD2_k127_1061685_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 299.0
HKD2_k127_1061685_3 Pilus formation protein N terminal region K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000906 322.0
HKD2_k127_1061685_4 type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000006699 226.0
HKD2_k127_1061685_6 COG0558 Phosphatidylglycerophosphate synthase - - - 0.0000000000000000000000000000000000000000000000000009121 189.0
HKD2_k127_1061685_7 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000000000000000005665 190.0
HKD2_k127_1061685_8 pilus assembly protein TadB K12510 - - 0.000000000000000000000000000000000000000000000002212 200.0
HKD2_k127_1061685_9 Flp pilus assembly protein, ATPase CpaE K02282 - - 0.000000000000000000000000000000000000000008945 171.0
HKD2_k127_1189362_0 Enoyl-CoA hydratase K16427 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042802,GO:0051213,GO:0055114 1.13.11.80 1.521e-230 721.0
HKD2_k127_1189362_1 His Kinase A (phosphoacceptor) domain K15011 - 2.7.13.3 9.059e-222 703.0
HKD2_k127_1189362_10 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 418.0
HKD2_k127_1189362_11 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 356.0
HKD2_k127_1189362_12 Bacterial regulatory protein, Fis family K15012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 377.0
HKD2_k127_1189362_13 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001161 264.0
HKD2_k127_1189362_14 transcriptional regulator K22105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005817 259.0
HKD2_k127_1189362_15 DsrE/DsrF-like family K09004 - - 0.000000000000000000000000000000000000000000000000000000000001619 217.0
HKD2_k127_1189362_16 - - - - 0.0000000000000000000000000000000000000000000000000001533 199.0
HKD2_k127_1189362_17 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000003204 125.0
HKD2_k127_1189362_18 AraC-like ligand binding domain - - - 0.000000000000000000000002371 106.0
HKD2_k127_1189362_19 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000002947 84.0
HKD2_k127_1189362_2 COG1960 Acyl-CoA dehydrogenases - - - 8.51e-217 677.0
HKD2_k127_1189362_3 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739 - 2.5.1.48 2.268e-210 659.0
HKD2_k127_1189362_4 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 3.613e-209 653.0
HKD2_k127_1189362_5 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 604.0
HKD2_k127_1189362_6 Belongs to the proline racemase family K01777 - 5.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004681 566.0
HKD2_k127_1189362_7 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 512.0
HKD2_k127_1189362_8 Nudix hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 488.0
HKD2_k127_1189362_9 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 503.0
HKD2_k127_1229160_0 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 477.0
HKD2_k127_1229160_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 430.0
HKD2_k127_1229160_2 Putative vitamin uptake transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 302.0
HKD2_k127_1229160_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002405 243.0
HKD2_k127_1229160_4 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000006653 194.0
HKD2_k127_1229452_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1132.0
HKD2_k127_1229452_1 AMP-binding enzyme K12508 - 6.2.1.34 0.0 1116.0
HKD2_k127_1229452_10 acyl-CoA dehydrogenase K00249 - 1.3.8.7 4.253e-231 746.0
HKD2_k127_1229452_11 Mate efflux family protein - - - 2.826e-222 698.0
HKD2_k127_1229452_12 Serine aminopeptidase, S33 K01253,K08253 - 2.7.10.2,3.3.2.9 2.179e-202 638.0
HKD2_k127_1229452_13 Acetyl-CoA hydrolase/transferase C-terminal domain K18288,K22214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 586.0
HKD2_k127_1229452_14 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 516.0
HKD2_k127_1229452_15 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 478.0
HKD2_k127_1229452_16 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 461.0
HKD2_k127_1229452_17 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 473.0
HKD2_k127_1229452_18 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 471.0
HKD2_k127_1229452_19 Ndr family K14727 - 3.1.1.24,4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 437.0
HKD2_k127_1229452_2 Amidohydrolase family - - - 1.057e-318 981.0
HKD2_k127_1229452_20 COG0477 Permeases of the major facilitator superfamily K13021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 421.0
HKD2_k127_1229452_21 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 407.0
HKD2_k127_1229452_22 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 404.0
HKD2_k127_1229452_23 Arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009079 400.0
HKD2_k127_1229452_24 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 387.0
HKD2_k127_1229452_25 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 385.0
HKD2_k127_1229452_26 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000351 386.0
HKD2_k127_1229452_27 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 366.0
HKD2_k127_1229452_28 Belongs to the HpcH HpaI aldolase family K01644,K18292 - 4.1.3.25,4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 323.0
HKD2_k127_1229452_29 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 316.0
HKD2_k127_1229452_3 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 3.795e-304 949.0
HKD2_k127_1229452_30 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 290.0
HKD2_k127_1229452_31 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 289.0
HKD2_k127_1229452_32 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 293.0
HKD2_k127_1229452_33 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000288 258.0
HKD2_k127_1229452_34 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001879 226.0
HKD2_k127_1229452_35 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.0000000000000000000000000000000000000000000000000000000000000002555 223.0
HKD2_k127_1229452_36 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.0000000000000000000000000000000000000000000000000000005028 193.0
HKD2_k127_1229452_37 Methylmuconolactone methyl-isomerase - - - 0.000000000000000000000000000000000000000000000003933 179.0
HKD2_k127_1229452_38 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000001524 175.0
HKD2_k127_1229452_39 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000007168 149.0
HKD2_k127_1229452_4 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.801e-298 923.0
HKD2_k127_1229452_41 - - - - 0.0000000000000000000000000000000001259 141.0
HKD2_k127_1229452_42 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00038,K17754 - 1.1.1.163,1.1.1.53 0.00000000000000000000000000032 115.0
HKD2_k127_1229452_43 SnoaL-like domain - - - 0.000000000000000000000000002316 115.0
HKD2_k127_1229452_44 Mannose-6-phosphate isomerase - - - 0.000000001591 65.0
HKD2_k127_1229452_46 nucleotidyltransferase activity K00984 - 2.7.7.47 0.000001741 53.0
HKD2_k127_1229452_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.297e-287 887.0
HKD2_k127_1229452_6 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 1.367e-258 806.0
HKD2_k127_1229452_7 Adenylate cyclase K01768 - 4.6.1.1 5.588e-248 777.0
HKD2_k127_1229452_8 PFAM amidohydrolase K07045 - - 4.097e-247 764.0
HKD2_k127_1229452_9 Belongs to the DEAD box helicase family - - - 3.523e-233 728.0
HKD2_k127_128766_0 Involved in beta-(1-- 2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP- binding domain (NBD) is responsible for energy generation K06147 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 0.0 1037.0
HKD2_k127_128766_1 Psort location Cytoplasmic, score 7.50 - - - 3.77e-223 695.0
HKD2_k127_128766_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K22185 - 1.1.1.175 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 431.0
HKD2_k127_128766_11 Isochorismatase family K09020 - 3.5.1.110 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 413.0
HKD2_k127_128766_12 Aldose 1-epimerase K01785 - 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 369.0
HKD2_k127_128766_13 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009629 338.0
HKD2_k127_128766_14 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000126 233.0
HKD2_k127_128766_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000573 124.0
HKD2_k127_128766_16 Protein of unknown function (DUF4242) - - - 0.00000000000005549 77.0
HKD2_k127_128766_2 Amidohydrolase family - - - 1.309e-199 627.0
HKD2_k127_128766_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 603.0
HKD2_k127_128766_4 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 590.0
HKD2_k127_128766_5 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 494.0
HKD2_k127_128766_6 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 481.0
HKD2_k127_128766_7 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 452.0
HKD2_k127_128766_8 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 470.0
HKD2_k127_128766_9 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 446.0
HKD2_k127_1288513_0 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 537.0
HKD2_k127_1288513_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 526.0
HKD2_k127_1288513_2 fad dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 441.0
HKD2_k127_1288513_3 EamA-like transporter family K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 365.0
HKD2_k127_1288513_4 Sigma-54 interaction domain K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000001059 64.0
HKD2_k127_1290030_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 9.589e-308 945.0
HKD2_k127_1290030_1 TonB-dependent receptor K16092 - - 8.157e-301 936.0
HKD2_k127_1290030_10 Belongs to the hyi family K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 497.0
HKD2_k127_1290030_11 N-formylglutamate amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 442.0
HKD2_k127_1290030_12 Class II Aldolase and Adducin N-terminal domain K22130 - 4.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 406.0
HKD2_k127_1290030_13 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008464 304.0
HKD2_k127_1290030_14 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000000000000001764 223.0
HKD2_k127_1290030_15 Protein of unknown function (DUF1244) K09948 - - 0.00000000000000000000000000000000000000000000000000001246 189.0
HKD2_k127_1290030_16 Fe-S protein - - - 0.0000000000000000000000000000000000003359 149.0
HKD2_k127_1290030_17 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000002815 78.0
HKD2_k127_1290030_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 8.011e-264 816.0
HKD2_k127_1290030_3 Cysteine-rich domain K11473 - - 1.241e-251 783.0
HKD2_k127_1290030_4 Amidohydrolase family - - - 2.707e-244 759.0
HKD2_k127_1290030_5 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.095e-235 747.0
HKD2_k127_1290030_6 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 8.14e-227 710.0
HKD2_k127_1290030_7 Putative sugar-binding N-terminal domain - - - 5.102e-225 704.0
HKD2_k127_1290030_8 FAD binding domain K11472 - - 8.689e-205 641.0
HKD2_k127_1290030_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 500.0
HKD2_k127_1307241_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 5.282e-243 758.0
HKD2_k127_1307241_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 6.67e-237 742.0
HKD2_k127_1307241_2 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 365.0
HKD2_k127_1307241_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000744 286.0
HKD2_k127_1307241_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000005513 217.0
HKD2_k127_1307241_5 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000000000003384 138.0
HKD2_k127_1307241_6 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.00000000000000000000000000001494 126.0
HKD2_k127_1307241_7 - - - - 0.0000000001881 62.0
HKD2_k127_1320357_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.0 1180.0
HKD2_k127_1320357_1 Serine/threonine phosphatases, family 2C, catalytic domain - - - 7.52e-219 687.0
HKD2_k127_1320357_2 CoA-transferase family III - - - 1.073e-198 623.0
HKD2_k127_1320357_3 Formate/nitrite transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009145 477.0
HKD2_k127_1320357_4 Putative FMN-binding domain K07734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 356.0
HKD2_k127_1320357_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000001321 214.0
HKD2_k127_1320357_6 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000000000003679 201.0
HKD2_k127_1320357_7 Rieske-like [2Fe-2S] domain K00363 - 1.7.1.15 0.0000000000000000000000000000000000000002567 172.0
HKD2_k127_1320357_8 Bacterial protein of unknown function (DUF839) K07093 - - 0.000009778 56.0
HKD2_k127_1327174_0 Belongs to the heme-copper respiratory oxidase family - - - 0.0 1013.0
HKD2_k127_1327174_1 Putative bacterial virulence factor - - - 1.721e-259 803.0
HKD2_k127_1327174_2 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 444.0
HKD2_k127_1327174_3 Cytochrome c oxidase subunit III K02299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 304.0
HKD2_k127_1327174_4 Prokaryotic Cytochrome C oxidase subunit IV K02300 - - 0.0000000000000000000000000000128 130.0
HKD2_k127_1332703_0 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.0 1111.0
HKD2_k127_1332703_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1104.0
HKD2_k127_1332703_10 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 9.27e-204 637.0
HKD2_k127_1332703_11 Transmembrane secretion effector - - - 9.167e-201 651.0
HKD2_k127_1332703_12 Carbon-nitrogen hydrolase - - - 1.53e-196 614.0
HKD2_k127_1332703_13 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 561.0
HKD2_k127_1332703_14 Binding-protein-dependent transport system inner membrane component K05814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 523.0
HKD2_k127_1332703_15 GDP-mannose 4,6 dehydratase K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 487.0
HKD2_k127_1332703_16 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 483.0
HKD2_k127_1332703_17 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 471.0
HKD2_k127_1332703_18 PFAM FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 419.0
HKD2_k127_1332703_19 KR domain K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 398.0
HKD2_k127_1332703_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - 5.546e-299 923.0
HKD2_k127_1332703_20 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 353.0
HKD2_k127_1332703_21 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 361.0
HKD2_k127_1332703_22 Ribosomal RNA adenine dimethylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 307.0
HKD2_k127_1332703_23 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 284.0
HKD2_k127_1332703_24 arsenite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004654 298.0
HKD2_k127_1332703_25 PFAM UspA domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006353 269.0
HKD2_k127_1332703_26 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000001905 246.0
HKD2_k127_1332703_27 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007489 241.0
HKD2_k127_1332703_28 Protein required for attachment to host cells - - - 0.0000000000000000000000000000000000000000000000000000000000007826 213.0
HKD2_k127_1332703_29 Invasion associated locus B (IalB) protein - - - 0.0000000000000000000000000000000000000000000000009111 182.0
HKD2_k127_1332703_3 Homospermidine synthase K00808 - 2.5.1.44 5.698e-270 835.0
HKD2_k127_1332703_30 ChaB K06197 - - 0.00000000000000000000000199 105.0
HKD2_k127_1332703_31 Transposase DDE domain - - - 0.00000000000000000000001424 100.0
HKD2_k127_1332703_32 TIGRFAM autotransporter-associated beta strand repeat protein - - - 0.000000000000002099 91.0
HKD2_k127_1332703_33 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00023 - 1.1.1.36 0.0000001552 59.0
HKD2_k127_1332703_34 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.0001686 48.0
HKD2_k127_1332703_4 Bacterial extracellular solute-binding protein K05813 - - 6.776e-256 793.0
HKD2_k127_1332703_5 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 1.02e-237 736.0
HKD2_k127_1332703_6 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.201e-237 749.0
HKD2_k127_1332703_7 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 4.517e-231 720.0
HKD2_k127_1332703_8 acetyltransferase - - - 1.341e-219 684.0
HKD2_k127_1332703_9 Autotransporter beta-domain - - - 6.557e-209 687.0
HKD2_k127_1339200_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 576.0
HKD2_k127_1339200_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 481.0
HKD2_k127_1339200_10 May be involved in the transport of PQQ or its precursor to the periplasm - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007689 269.0
HKD2_k127_1339200_11 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000004756 260.0
HKD2_k127_1339200_12 Protein of unknown function (DUF992) - - - 0.00000000000000000000000000000000000000000000000000000000000004076 222.0
HKD2_k127_1339200_13 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000000006656 228.0
HKD2_k127_1339200_14 Beta-glucanase Beta-glucan synthetase K16559 - - 0.0000000000000000000000000000000000000000000000000000000143 219.0
HKD2_k127_1339200_15 - - - - 0.0000000000000000000000000000000000000000000000000001569 193.0
HKD2_k127_1339200_16 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000102 194.0
HKD2_k127_1339200_17 Glycosyltransferase like family 2 - - - 0.000000000000000000000003101 110.0
HKD2_k127_1339200_18 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.000000000000000000005729 104.0
HKD2_k127_1339200_19 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000001303 100.0
HKD2_k127_1339200_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 477.0
HKD2_k127_1339200_22 Iron-sulfur cluster-binding domain - - - 0.00000000000005721 83.0
HKD2_k127_1339200_23 Transposase - - - 0.0000000000001761 74.0
HKD2_k127_1339200_24 O-methyltransferase activity - - - 0.000000000001858 78.0
HKD2_k127_1339200_26 COG4584 Transposase and inactivated derivatives - - - 0.0001803 47.0
HKD2_k127_1339200_27 FecR protein - - - 0.0002146 48.0
HKD2_k127_1339200_3 Dehydrogenase E1 component K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 463.0
HKD2_k127_1339200_4 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 421.0
HKD2_k127_1339200_5 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 389.0
HKD2_k127_1339200_6 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 392.0
HKD2_k127_1339200_7 Peptidase family M50 K06402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 383.0
HKD2_k127_1339200_8 RecQ zinc-binding K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006 351.0
HKD2_k127_1339200_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001398 265.0
HKD2_k127_1347703_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.306e-253 786.0
HKD2_k127_1347703_1 Acyl-CoA dehydrogenase, middle domain - - - 1.025e-244 766.0
HKD2_k127_1347703_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 6.733e-196 616.0
HKD2_k127_1347703_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 373.0
HKD2_k127_1356483_0 Acetyl-coenzyme A transporter 1 K08218 - - 1.197e-203 647.0
HKD2_k127_1356483_1 Major facilitator superfamily K07552 - - 2.453e-199 627.0
HKD2_k127_1356483_2 WD40 repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 605.0
HKD2_k127_1356483_3 COG0524 Sugar kinases, ribokinase family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 569.0
HKD2_k127_1356483_4 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 428.0
HKD2_k127_1356483_5 DsrE/DsrF-like family - - - 0.000000000000000000000000000000000000000000000000000000000006443 222.0
HKD2_k127_1356483_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000000000000000000000003233 149.0
HKD2_k127_1363656_0 AcrB/AcrD/AcrF family - - - 0.0 1741.0
HKD2_k127_1363656_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 4.474e-297 915.0
HKD2_k127_1363656_10 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 455.0
HKD2_k127_1363656_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 403.0
HKD2_k127_1363656_12 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 401.0
HKD2_k127_1363656_13 HlyD membrane-fusion protein of T1SS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 343.0
HKD2_k127_1363656_14 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 291.0
HKD2_k127_1363656_15 redox protein, regulator of disulfide bond formation K07397 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007568 251.0
HKD2_k127_1363656_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001147 250.0
HKD2_k127_1363656_17 Protein of unknown function (DUF3225) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004505 237.0
HKD2_k127_1363656_18 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000000000000000002395 218.0
HKD2_k127_1363656_19 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000007235 220.0
HKD2_k127_1363656_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.88e-294 911.0
HKD2_k127_1363656_20 Flavodoxin domain K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000001042 218.0
HKD2_k127_1363656_21 ABC transporter K02035 - - 0.000000000000000000000000000000000000000000000000000000000007941 223.0
HKD2_k127_1363656_22 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000000000000000004614 154.0
HKD2_k127_1363656_23 Belongs to the BolA IbaG family - - - 0.000000000000000000000000000000000000002463 147.0
HKD2_k127_1363656_25 - - - - 0.0000000000000000000000000000001215 140.0
HKD2_k127_1363656_3 Major Facilitator Superfamily - - - 3.304e-243 760.0
HKD2_k127_1363656_4 FAD dependent oxidoreductase - - - 1.271e-225 705.0
HKD2_k127_1363656_5 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 9.479e-215 670.0
HKD2_k127_1363656_6 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 1.054e-196 617.0
HKD2_k127_1363656_7 Barrel-sandwich domain of CusB or HlyD membrane-fusion K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 556.0
HKD2_k127_1363656_8 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 497.0
HKD2_k127_1363656_9 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 460.0
HKD2_k127_1367361_0 ATPase with chaperone activity K07391 - - 1.269e-286 901.0
HKD2_k127_1367361_1 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005132 586.0
HKD2_k127_1367361_10 PFAM Hemerythrin HHE cation binding domain - - - 0.00000000000006465 79.0
HKD2_k127_1367361_11 PFAM Uncharacterised protein family UPF0150 - - - 0.00001179 52.0
HKD2_k127_1367361_12 ATPase with chaperone activity K07391 - - 0.0003987 44.0
HKD2_k127_1367361_2 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 544.0
HKD2_k127_1367361_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 462.0
HKD2_k127_1367361_4 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 416.0
HKD2_k127_1367361_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001282 306.0
HKD2_k127_1367361_6 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000001579 228.0
HKD2_k127_1367361_7 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.000000000000000000000000000000000000000000000000000000000001011 212.0
HKD2_k127_1367361_8 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000000000000001406 151.0
HKD2_k127_1367361_9 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000001341 116.0
HKD2_k127_1384308_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 7.673e-226 704.0
HKD2_k127_1384308_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 1.665e-215 671.0
HKD2_k127_1384308_2 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 500.0
HKD2_k127_1384308_3 chorismate mutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 461.0
HKD2_k127_1384308_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 456.0
HKD2_k127_1384308_5 methionine biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 381.0
HKD2_k127_1384308_6 prephenate dehydrogenase K00220 - 1.3.1.12,1.3.1.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 363.0
HKD2_k127_1384308_7 Peptidase S24-like K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000008183 242.0
HKD2_k127_1384308_8 ybak prolyl-trna synthetase associated K19055 - - 0.000000000000000000000000000000000001161 144.0
HKD2_k127_1384308_9 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000008576 70.0
HKD2_k127_1401246_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 1.034e-238 739.0
HKD2_k127_1401246_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 3.011e-199 623.0
HKD2_k127_1401246_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001927 263.0
HKD2_k127_1401246_11 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000000000000001238 181.0
HKD2_k127_1401246_12 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000000000002691 150.0
HKD2_k127_1401246_13 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000002466 137.0
HKD2_k127_1401246_14 YHS domain protein - - - 0.00000000000000000000000000000009311 130.0
HKD2_k127_1401246_15 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000005111 110.0
HKD2_k127_1401246_17 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000435 64.0
HKD2_k127_1401246_18 receptor - - - 0.000000004404 60.0
HKD2_k127_1401246_19 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00004754 45.0
HKD2_k127_1401246_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 3.485e-198 624.0
HKD2_k127_1401246_3 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 1.487e-195 613.0
HKD2_k127_1401246_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 586.0
HKD2_k127_1401246_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 469.0
HKD2_k127_1401246_6 Aldo/keto reductase family K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 467.0
HKD2_k127_1401246_7 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 480.0
HKD2_k127_1401246_8 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 364.0
HKD2_k127_1401246_9 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 317.0
HKD2_k127_1408059_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family - - - 0.0 1585.0
HKD2_k127_1408059_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 998.0
HKD2_k127_1408059_10 metal-dependent membrane protease - - - 0.0000000000000000000000000000000000000000000000000011 194.0
HKD2_k127_1408059_11 - - - - 0.0000000000000000000000000000000000000001429 154.0
HKD2_k127_1408059_12 Cold shock K03704 - - 0.00000000000000000000000000313 128.0
HKD2_k127_1408059_13 - - - - 0.00000000000000000000008227 113.0
HKD2_k127_1408059_14 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000001007 68.0
HKD2_k127_1408059_15 sequence-specific DNA binding - - - 0.00000000444 67.0
HKD2_k127_1408059_19 - - - - 0.000003768 55.0
HKD2_k127_1408059_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.009e-273 848.0
HKD2_k127_1408059_20 Recombinase zinc beta ribbon domain - - - 0.0005888 46.0
HKD2_k127_1408059_3 PFAM Acyl-CoA dehydrogenase type 2 K16047 - 1.14.14.12 1.838e-199 655.0
HKD2_k127_1408059_4 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 543.0
HKD2_k127_1408059_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 489.0
HKD2_k127_1408059_6 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 460.0
HKD2_k127_1408059_7 Periplasmic binding protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 450.0
HKD2_k127_1408059_8 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 385.0
HKD2_k127_1408059_9 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 331.0
HKD2_k127_1412957_0 AcrB/AcrD/AcrF family K18138 - - 0.0 1630.0
HKD2_k127_1412957_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 428.0
HKD2_k127_1412957_2 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 356.0
HKD2_k127_1412957_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 340.0
HKD2_k127_1419853_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 1.839e-265 822.0
HKD2_k127_1419853_1 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 3.292e-261 808.0
HKD2_k127_1419853_11 transcriptional regulator - - - 0.000000000000000000004531 104.0
HKD2_k127_1419853_2 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 4.125e-205 649.0
HKD2_k127_1419853_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006595 514.0
HKD2_k127_1419853_4 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 490.0
HKD2_k127_1419853_5 protein conserved in bacteria K09921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 434.0
HKD2_k127_1419853_6 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 415.0
HKD2_k127_1419853_7 2-oxohepta-3-ene-1,7-dioic acid hydratase K01617,K02509 - 4.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 362.0
HKD2_k127_1419853_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007268 274.0
HKD2_k127_1419853_9 4-hydroxyphenylacetate 3-monooxygenase oxygenase K00483 - 1.14.14.9 0.00000000000000000000000000000000000000000000395 183.0
HKD2_k127_1425846_0 AIR synthase related protein, C-terminal domain - - - 0.0 1124.0
HKD2_k127_1425846_1 dioxygenase K11159 - - 3.936e-286 881.0
HKD2_k127_1425846_10 oligosaccharyl transferase activity - - - 4.799e-197 626.0
HKD2_k127_1425846_11 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 622.0
HKD2_k127_1425846_12 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 603.0
HKD2_k127_1425846_13 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 598.0
HKD2_k127_1425846_14 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 534.0
HKD2_k127_1425846_15 NUDIX domain K00949 - 2.7.6.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 471.0
HKD2_k127_1425846_16 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 463.0
HKD2_k127_1425846_17 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 456.0
HKD2_k127_1425846_18 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 413.0
HKD2_k127_1425846_19 Thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 403.0
HKD2_k127_1425846_2 Amidase K02433 - 6.3.5.6,6.3.5.7 7.518e-281 887.0
HKD2_k127_1425846_20 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 398.0
HKD2_k127_1425846_21 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 375.0
HKD2_k127_1425846_22 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 367.0
HKD2_k127_1425846_23 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 368.0
HKD2_k127_1425846_24 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 376.0
HKD2_k127_1425846_25 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 352.0
HKD2_k127_1425846_26 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007926 357.0
HKD2_k127_1425846_27 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 332.0
HKD2_k127_1425846_28 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 333.0
HKD2_k127_1425846_29 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007374 304.0
HKD2_k127_1425846_3 repeat protein - - - 1.116e-268 833.0
HKD2_k127_1425846_30 transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000002738 232.0
HKD2_k127_1425846_31 bond formation protein, DsbB - - - 0.00000000000000000000000000000000000000000000000000000000000000004449 226.0
HKD2_k127_1425846_32 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000001342 218.0
HKD2_k127_1425846_33 - - - - 0.000000000000000000000000000000000000000000000000000000000003959 216.0
HKD2_k127_1425846_34 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000000000000000000000123 196.0
HKD2_k127_1425846_38 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000424 168.0
HKD2_k127_1425846_39 Transposase - - - 0.000000000000000000000000000000000000000001046 157.0
HKD2_k127_1425846_4 Amidase K02433 - 6.3.5.6,6.3.5.7 1.13e-246 796.0
HKD2_k127_1425846_40 FecR protein - - - 0.000000000000000000000000000661 126.0
HKD2_k127_1425846_41 - - - - 0.000000000000000000000000001859 117.0
HKD2_k127_1425846_42 transposase activity - - - 0.00000000000000000000000001492 114.0
HKD2_k127_1425846_43 DNA-dependent DNA replication - - - 0.0000000000000003286 93.0
HKD2_k127_1425846_45 - - - - 0.00000007287 61.0
HKD2_k127_1425846_46 - - - - 0.00002049 55.0
HKD2_k127_1425846_47 AraC family transcriptional regulator - - - 0.00005935 52.0
HKD2_k127_1425846_5 Belongs to the CinA family - - - 2.955e-224 700.0
HKD2_k127_1425846_6 COG0457 FOG TPR repeat - - - 1.787e-222 716.0
HKD2_k127_1425846_7 Beta-lactamase - - - 2.283e-218 697.0
HKD2_k127_1425846_8 Ring hydroxylating alpha subunit (catalytic domain) - - - 9.201e-212 661.0
HKD2_k127_1425846_9 Methionine synthase K00549 - 2.1.1.14 3.61e-208 651.0
HKD2_k127_1454860_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 0.0 1132.0
HKD2_k127_1454860_1 oligoendopeptidase F K08602 - - 0.0 1094.0
HKD2_k127_1454860_10 Amidohydrolase family - - - 1.271e-229 721.0
HKD2_k127_1454860_11 transhydrogenase subunit alpha K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 6.436e-206 647.0
HKD2_k127_1454860_12 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 557.0
HKD2_k127_1454860_13 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 545.0
HKD2_k127_1454860_14 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 541.0
HKD2_k127_1454860_15 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005639 533.0
HKD2_k127_1454860_16 epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 535.0
HKD2_k127_1454860_17 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 373.0
HKD2_k127_1454860_18 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 326.0
HKD2_k127_1454860_19 Protein of unknown function (DUF2390) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 290.0
HKD2_k127_1454860_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0 1042.0
HKD2_k127_1454860_20 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005539 306.0
HKD2_k127_1454860_21 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006909 272.0
HKD2_k127_1454860_23 Flavoprotein K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000002218 265.0
HKD2_k127_1454860_25 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000009327 235.0
HKD2_k127_1454860_26 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000004434 231.0
HKD2_k127_1454860_27 Vancomycin high temperature exclusion protein K03748 - - 0.000000000000000000000000000000000000000000000000000000000002128 236.0
HKD2_k127_1454860_28 COQ9 K18587 - - 0.000000000000000000000000000000000000000000000000000000006499 205.0
HKD2_k127_1454860_3 AMP-binding enzyme C-terminal domain K00666 - - 0.0 1042.0
HKD2_k127_1454860_30 GAF domain - - - 0.000000000000000000000000000000000000008113 156.0
HKD2_k127_1454860_31 - - - - 0.0000000000000000000000000000000000006439 161.0
HKD2_k127_1454860_32 Protein of unknown function (DUF1275) - - - 0.000000000000000000000000000000008563 139.0
HKD2_k127_1454860_33 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.00000000000000000000000000001171 119.0
HKD2_k127_1454860_34 Protein of unknown function (DUF465) - - - 0.000000000000000000000000005092 111.0
HKD2_k127_1454860_35 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000002352 102.0
HKD2_k127_1454860_36 Protein of unknown function (DUF465) - - - 0.00000000000000000001152 93.0
HKD2_k127_1454860_37 - - - - 0.000007552 58.0
HKD2_k127_1454860_4 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 3.513e-319 980.0
HKD2_k127_1454860_5 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 3.874e-281 869.0
HKD2_k127_1454860_6 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 2.098e-263 824.0
HKD2_k127_1454860_7 ABC1 family - - - 9.988e-260 803.0
HKD2_k127_1454860_8 histidine ammonia-lyase activity K01745 - 4.3.1.3 1.904e-254 792.0
HKD2_k127_1454860_9 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 1.526e-232 723.0
HKD2_k127_1466706_0 Phosphotransferase enzyme family - - - 7.808e-204 638.0
HKD2_k127_1466706_1 His Kinase A (phosphoacceptor) domain - - - 3.132e-203 672.0
HKD2_k127_1466706_10 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 314.0
HKD2_k127_1466706_11 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 319.0
HKD2_k127_1466706_12 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 316.0
HKD2_k127_1466706_13 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008358 293.0
HKD2_k127_1466706_14 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.000000000000000000000000000000000000000000000000000000000000000000000001148 261.0
HKD2_k127_1466706_15 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000000000000000000001746 220.0
HKD2_k127_1466706_17 Nacht domain - - - 0.000000000000000000000000000000000000000000000004148 199.0
HKD2_k127_1466706_18 cheY-homologous receiver domain K11443 - - 0.0000000000000000000000000000000000000001549 158.0
HKD2_k127_1466706_19 Enoyl-CoA hydratase carnithine racemase - - - 0.0000000000000000000000000000000000002499 153.0
HKD2_k127_1466706_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 582.0
HKD2_k127_1466706_20 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000001027 94.0
HKD2_k127_1466706_21 COG3316 Transposase and inactivated derivatives K07498 - - 0.00000001131 56.0
HKD2_k127_1466706_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 492.0
HKD2_k127_1466706_4 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 478.0
HKD2_k127_1466706_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 479.0
HKD2_k127_1466706_6 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 407.0
HKD2_k127_1466706_7 TIGRFAM TRAP transporter solute receptor, TAXI family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 357.0
HKD2_k127_1466706_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 364.0
HKD2_k127_1466706_9 Peptidase C13 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 331.0
HKD2_k127_150100_0 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.011e-298 919.0
HKD2_k127_150100_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 9.345e-201 627.0
HKD2_k127_150100_10 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.000000000001801 80.0
HKD2_k127_150100_11 Domain of unknown function (DUF4215) - - - 0.0003659 55.0
HKD2_k127_150100_2 helix_turn_helix isocitrate lyase regulation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 578.0
HKD2_k127_150100_3 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 596.0
HKD2_k127_150100_4 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 486.0
HKD2_k127_150100_5 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 409.0
HKD2_k127_150100_6 Rhs Family - - - 0.0000000000000000000000000000000000000000000000000000000000000002434 253.0
HKD2_k127_150100_7 - - - - 0.00000000000000000000000000000000000000000000001925 174.0
HKD2_k127_150100_8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000000000000000000002748 144.0
HKD2_k127_150100_9 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000001259 139.0
HKD2_k127_151271_0 FAD linked oxidases, C-terminal domain K18930 - - 0.0 1749.0
HKD2_k127_151271_1 Binding-protein-dependent transport system inner membrane component - - - 0.0 1018.0
HKD2_k127_151271_10 COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 538.0
HKD2_k127_151271_11 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008131 528.0
HKD2_k127_151271_12 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 496.0
HKD2_k127_151271_13 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 492.0
HKD2_k127_151271_14 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 498.0
HKD2_k127_151271_15 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 523.0
HKD2_k127_151271_16 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 464.0
HKD2_k127_151271_17 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 425.0
HKD2_k127_151271_18 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 419.0
HKD2_k127_151271_19 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 398.0
HKD2_k127_151271_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.042e-309 953.0
HKD2_k127_151271_20 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 310.0
HKD2_k127_151271_21 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 297.0
HKD2_k127_151271_22 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009309 271.0
HKD2_k127_151271_23 chaperone-mediated protein folding - GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009627 273.0
HKD2_k127_151271_24 ABC-type nitrate sulfonate bicarbonate transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000005217 232.0
HKD2_k127_151271_25 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000000000000000000000227 132.0
HKD2_k127_151271_26 - - - - 0.000000000000000001638 92.0
HKD2_k127_151271_3 Amidohydrolase family - - - 4.206e-266 827.0
HKD2_k127_151271_4 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 4.693e-219 682.0
HKD2_k127_151271_5 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 6.215e-207 649.0
HKD2_k127_151271_6 Aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 1.512e-200 631.0
HKD2_k127_151271_7 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 603.0
HKD2_k127_151271_8 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 570.0
HKD2_k127_151271_9 Fusaric acid resistance protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 560.0
HKD2_k127_1514907_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 1.901e-285 887.0
HKD2_k127_1514907_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 603.0
HKD2_k127_1514907_2 Histidine phosphatase superfamily (branch 2) K01093 - 3.1.3.2,3.1.3.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 519.0
HKD2_k127_1514907_3 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 433.0
HKD2_k127_1514907_4 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12262 - - 0.00000000000000000000000000000000000000000000000000000002239 203.0
HKD2_k127_1529897_0 Flavin-binding monooxygenase-like K03379,K21730 - 1.14.13.160,1.14.13.22 7.463e-288 889.0
HKD2_k127_1529897_1 Flavin-binding monooxygenase-like K07222 - - 1.801e-218 692.0
HKD2_k127_1529897_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 366.0
HKD2_k127_1529897_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.0000000000000000000000000000000000000000000000000000000000000000000000107 252.0
HKD2_k127_1529897_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000003383 196.0
HKD2_k127_1529897_6 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000001666 187.0
HKD2_k127_1529897_7 - - - - 0.00000000000000000000000000000000000000000009715 173.0
HKD2_k127_1529897_8 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000008835 158.0
HKD2_k127_1529897_9 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000001256 143.0
HKD2_k127_1568902_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K13482 - 1.17.1.4 0.0 1297.0
HKD2_k127_1568902_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 1.256e-238 739.0
HKD2_k127_1568902_2 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 8.434e-214 673.0
HKD2_k127_1568902_3 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 453.0
HKD2_k127_1568902_4 COX Aromatic Rich Motif K02297 - 1.10.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 389.0
HKD2_k127_1568902_6 Belongs to the heme-copper respiratory oxidase family - - - 0.0000000000000000000000000000000000000006248 162.0
HKD2_k127_1568902_7 transposase activity - - - 0.00000000000000000000000000000006743 143.0
HKD2_k127_1583830_0 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 561.0
HKD2_k127_1583830_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 315.0
HKD2_k127_1583830_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 295.0
HKD2_k127_1583830_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000008328 165.0
HKD2_k127_1583830_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0000000000000000000000000000009527 121.0
HKD2_k127_1583830_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000001355 114.0
HKD2_k127_1583830_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000001813 111.0
HKD2_k127_1583830_7 plasmid maintenance system antidote protein K21498 - - 0.000000000000000000002318 98.0
HKD2_k127_1583830_8 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000008862 59.0
HKD2_k127_1595967_0 Amidase K02433 - 6.3.5.6,6.3.5.7 1.409e-272 841.0
HKD2_k127_1595967_1 transcriptional regulator - - - 1.099e-225 711.0
HKD2_k127_1595967_2 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 540.0
HKD2_k127_1595967_3 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 476.0
HKD2_k127_1595967_4 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 365.0
HKD2_k127_1595967_5 Pfam:AmoA K07120 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009256 347.0
HKD2_k127_1595967_6 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 340.0
HKD2_k127_1595967_7 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004423 282.0
HKD2_k127_1595967_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000001037 219.0
HKD2_k127_1595967_9 - - - - 0.000000000001103 68.0
HKD2_k127_1602144_0 Sulfatase K01130 - 3.1.6.1 9.893e-315 964.0
HKD2_k127_1602144_1 COG1960 Acyl-CoA dehydrogenases K14448 - 1.3.8.12 2.262e-310 971.0
HKD2_k127_1602144_10 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000001885 144.0
HKD2_k127_1602144_11 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000001373 140.0
HKD2_k127_1602144_12 Aha1 domain protein - - - 0.0000000000000000000000000000002584 128.0
HKD2_k127_1602144_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K14446 - 1.3.1.85 2.357e-285 878.0
HKD2_k127_1602144_3 Luciferase-like monooxygenase - - - 2.706e-285 876.0
HKD2_k127_1602144_4 Serine aminopeptidase, S33 K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 462.0
HKD2_k127_1602144_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 444.0
HKD2_k127_1602144_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 346.0
HKD2_k127_1602144_7 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 315.0
HKD2_k127_1602144_9 Domain of unknown function (DUF427) - - - 0.00000000000000000000000000000000000000000004866 162.0
HKD2_k127_1695860_0 protein involved in outer membrane biogenesis - - - 0.0 1215.0
HKD2_k127_1695860_1 Carbohydrate-selective porin, OprB family K16080 - - 0.0 1046.0
HKD2_k127_1695860_10 CoA-transferase family III - - - 2.548e-199 634.0
HKD2_k127_1695860_11 N-terminal domain of oxidoreductase K07119 - - 2.061e-196 616.0
HKD2_k127_1695860_12 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 601.0
HKD2_k127_1695860_13 Cobalamin synthesis protein cobW C-terminal domain K02234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 588.0
HKD2_k127_1695860_14 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 563.0
HKD2_k127_1695860_15 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 541.0
HKD2_k127_1695860_16 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 547.0
HKD2_k127_1695860_17 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 526.0
HKD2_k127_1695860_18 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 509.0
HKD2_k127_1695860_19 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008984 481.0
HKD2_k127_1695860_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0 1007.0
HKD2_k127_1695860_20 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 494.0
HKD2_k127_1695860_21 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 456.0
HKD2_k127_1695860_22 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 435.0
HKD2_k127_1695860_23 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009393 423.0
HKD2_k127_1695860_24 COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase K02225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 419.0
HKD2_k127_1695860_25 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 405.0
HKD2_k127_1695860_26 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 394.0
HKD2_k127_1695860_27 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 374.0
HKD2_k127_1695860_28 Major intrinsic protein K02440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 360.0
HKD2_k127_1695860_29 Transposase IS116/IS110/IS902 family K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 363.0
HKD2_k127_1695860_3 Carbohydrate-selective porin, OprB family K16080 - - 3.227e-274 858.0
HKD2_k127_1695860_30 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 334.0
HKD2_k127_1695860_31 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 292.0
HKD2_k127_1695860_32 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009112 252.0
HKD2_k127_1695860_33 Probable cobalt transporter subunit (CbtA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001397 243.0
HKD2_k127_1695860_34 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000004651 229.0
HKD2_k127_1695860_35 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000009183 223.0
HKD2_k127_1695860_36 - - - - 0.0000000000000000000000000000000000000000000000001608 187.0
HKD2_k127_1695860_37 Protein of unknown function (DUF1636) - - - 0.0000000000000000000000000000000000000000008086 168.0
HKD2_k127_1695860_38 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000002065 141.0
HKD2_k127_1695860_39 - - - - 0.00000000000000000000000000000000002257 138.0
HKD2_k127_1695860_4 Adenylate cyclase K01768 - 4.6.1.1 1.572e-267 840.0
HKD2_k127_1695860_41 Response regulator receiver - - - 0.00000000000000001447 91.0
HKD2_k127_1695860_42 - - - - 0.00000000000000002775 88.0
HKD2_k127_1695860_43 nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000005514 89.0
HKD2_k127_1695860_44 Probable cobalt transporter subunit (CbtB) - - - 0.000000000001303 79.0
HKD2_k127_1695860_45 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138,K18303,K21134 - - 0.00000003639 65.0
HKD2_k127_1695860_46 Response regulator receiver - - - 0.0000537 52.0
HKD2_k127_1695860_5 Aminotransferase class-III K01845 - 5.4.3.8 3.206e-244 758.0
HKD2_k127_1695860_6 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 3.147e-237 746.0
HKD2_k127_1695860_7 Uncharacterized ACR, YdiU/UPF0061 family - - - 1.305e-234 734.0
HKD2_k127_1695860_8 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 4.224e-228 708.0
HKD2_k127_1695860_9 Receptor family ligand binding region K01999 - - 1.019e-211 664.0
HKD2_k127_173575_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0 1131.0
HKD2_k127_173575_1 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 3.667e-304 959.0
HKD2_k127_173575_10 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 431.0
HKD2_k127_173575_11 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 428.0
HKD2_k127_173575_12 transcriptional regulator K05818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 302.0
HKD2_k127_173575_13 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005526 275.0
HKD2_k127_173575_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001095 246.0
HKD2_k127_173575_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 9.178e-277 859.0
HKD2_k127_173575_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 1.936e-257 797.0
HKD2_k127_173575_4 Belongs to the ABC transporter superfamily - - - 9.743e-199 622.0
HKD2_k127_173575_5 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K19745 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 582.0
HKD2_k127_173575_6 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 570.0
HKD2_k127_173575_7 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 544.0
HKD2_k127_173575_8 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 503.0
HKD2_k127_173575_9 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 488.0
HKD2_k127_1777772_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0 1404.0
HKD2_k127_1777772_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1371.0
HKD2_k127_1777772_10 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 531.0
HKD2_k127_1777772_11 Methyltransferase K06968 - 2.1.1.186 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 512.0
HKD2_k127_1777772_12 pathogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 462.0
HKD2_k127_1777772_13 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 438.0
HKD2_k127_1777772_14 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 357.0
HKD2_k127_1777772_15 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 297.0
HKD2_k127_1777772_16 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 298.0
HKD2_k127_1777772_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001525 258.0
HKD2_k127_1777772_18 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000507 254.0
HKD2_k127_1777772_19 protein containing double-stranded beta helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000228 240.0
HKD2_k127_1777772_2 Surface antigen K07278 - - 1.23e-272 852.0
HKD2_k127_1777772_20 Sel1-like repeats. - - - 0.00000000000000000000000000000000000000000000000000000000000000000004661 240.0
HKD2_k127_1777772_21 COG2346 Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000000000000000001846 216.0
HKD2_k127_1777772_22 Transcriptional regulator K13771 - - 0.0000000000000000000000000000000000000000000000000000000009688 204.0
HKD2_k127_1777772_23 phosphinothricin N-acetyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000003582 202.0
HKD2_k127_1777772_25 Outer membrane protein beta-barrel domain K16079 - - 0.00000000000000000000000000000000000000005473 168.0
HKD2_k127_1777772_26 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000006651 139.0
HKD2_k127_1777772_27 Protein of unknown function (DUF559) K07316 - 2.1.1.72 0.000000000000000000000000000000001255 132.0
HKD2_k127_1777772_29 DSBA-like thioredoxin domain - - - 0.000000000000000000000000003965 126.0
HKD2_k127_1777772_3 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain - - - 1.002e-245 760.0
HKD2_k127_1777772_30 - - - - 0.00000000000000000000000001023 116.0
HKD2_k127_1777772_31 - - - - 0.00000000000000000000000891 111.0
HKD2_k127_1777772_32 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.00000000000001603 79.0
HKD2_k127_1777772_4 BFD-like [2Fe-2S] binding domain - - - 1.462e-240 750.0
HKD2_k127_1777772_5 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.126e-226 714.0
HKD2_k127_1777772_6 FAD dependent oxidoreductase - - - 3.932e-219 682.0
HKD2_k127_1777772_7 Amidohydrolase - - - 4.745e-207 650.0
HKD2_k127_1777772_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 582.0
HKD2_k127_1777772_9 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 571.0
HKD2_k127_1816212_0 Radical SAM superfamily K11779 - 2.5.1.77 4.206e-266 827.0
HKD2_k127_1816212_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 479.0
HKD2_k127_1816212_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 471.0
HKD2_k127_1816212_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 468.0
HKD2_k127_1865237_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.0 1049.0
HKD2_k127_1865237_1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 381.0
HKD2_k127_1865237_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 336.0
HKD2_k127_1865237_3 Belongs to the urease gamma subunit family K01430 - 3.5.1.5 0.000000000000000000000000000000000000000000000001117 175.0
HKD2_k127_1865237_4 Antibiotic biosynthesis monooxygenase - - - 0.00000000000001136 79.0
HKD2_k127_1867551_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.392e-278 861.0
HKD2_k127_1867551_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 2.428e-274 850.0
HKD2_k127_1867551_10 Dyp-type peroxidase family K07223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 520.0
HKD2_k127_1867551_11 Nitrilotriacetate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 522.0
HKD2_k127_1867551_12 PFAM Integrase catalytic region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 468.0
HKD2_k127_1867551_13 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 462.0
HKD2_k127_1867551_14 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 471.0
HKD2_k127_1867551_15 Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 470.0
HKD2_k127_1867551_16 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 446.0
HKD2_k127_1867551_17 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 427.0
HKD2_k127_1867551_18 AMP-binding enzyme K00666,K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 440.0
HKD2_k127_1867551_19 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 410.0
HKD2_k127_1867551_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 4.696e-268 831.0
HKD2_k127_1867551_20 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 408.0
HKD2_k127_1867551_21 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 411.0
HKD2_k127_1867551_22 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 360.0
HKD2_k127_1867551_23 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 349.0
HKD2_k127_1867551_24 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 329.0
HKD2_k127_1867551_25 binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000922 320.0
HKD2_k127_1867551_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 321.0
HKD2_k127_1867551_27 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 321.0
HKD2_k127_1867551_28 C4-dicarboxylate transporter malic acid transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 318.0
HKD2_k127_1867551_29 toxin biosynthetic process K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 302.0
HKD2_k127_1867551_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 1.724e-258 801.0
HKD2_k127_1867551_30 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001093 276.0
HKD2_k127_1867551_31 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001852 266.0
HKD2_k127_1867551_32 COG1520 FOG WD40-like repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007044 280.0
HKD2_k127_1867551_33 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 255.0
HKD2_k127_1867551_34 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005418 263.0
HKD2_k127_1867551_35 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000003158 234.0
HKD2_k127_1867551_36 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001278 237.0
HKD2_k127_1867551_37 - - - - 0.000000000000000000000000000000000000000000000000000000000001819 239.0
HKD2_k127_1867551_38 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000007451 194.0
HKD2_k127_1867551_39 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000003315 206.0
HKD2_k127_1867551_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 2.066e-229 717.0
HKD2_k127_1867551_40 ArsC family - - - 0.0000000000000000000000000000000000000000000000000004095 194.0
HKD2_k127_1867551_41 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000001922 179.0
HKD2_k127_1867551_42 - - - - 0.000000000000000000000000000000000000000003758 160.0
HKD2_k127_1867551_43 Oxidoreductase K19336 - - 0.0000000000000000000000000000000000000001753 162.0
HKD2_k127_1867551_44 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000000000001218 148.0
HKD2_k127_1867551_46 PFAM Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000001053 143.0
HKD2_k127_1867551_47 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000002417 135.0
HKD2_k127_1867551_48 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.0000000000000000000000003157 117.0
HKD2_k127_1867551_49 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.00000000000000000000004537 104.0
HKD2_k127_1867551_5 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 9.077e-214 670.0
HKD2_k127_1867551_50 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000001013 101.0
HKD2_k127_1867551_51 glyoxalase K06996 - - 0.00000000000261 68.0
HKD2_k127_1867551_52 - - - - 0.00000000002738 67.0
HKD2_k127_1867551_53 - - - - 0.0000009654 59.0
HKD2_k127_1867551_6 trisaccharide binding - - - 1.117e-210 684.0
HKD2_k127_1867551_7 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 1.786e-204 643.0
HKD2_k127_1867551_8 PLD-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 538.0
HKD2_k127_1867551_9 Function of homologous gene experimentally demonstrated in an other organism K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007341 515.0
HKD2_k127_1883579_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.003e-268 854.0
HKD2_k127_1883579_1 L-lactate permease K03303 - - 1.037e-237 742.0
HKD2_k127_1883579_10 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 342.0
HKD2_k127_1883579_11 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 300.0
HKD2_k127_1883579_12 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000001035 253.0
HKD2_k127_1883579_14 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000005242 179.0
HKD2_k127_1883579_16 Protein of unknown function (DUF433) - - - 0.0000000000000000000000001002 108.0
HKD2_k127_1883579_17 - - - - 0.00000000000000000000001569 105.0
HKD2_k127_1883579_2 Pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 1.01e-215 676.0
HKD2_k127_1883579_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 5.28e-199 625.0
HKD2_k127_1883579_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 516.0
HKD2_k127_1883579_5 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 507.0
HKD2_k127_1883579_6 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 457.0
HKD2_k127_1883579_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009064 428.0
HKD2_k127_1883579_8 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 426.0
HKD2_k127_1883579_9 Glutathione S-transferase, N-terminal domain K11208 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 365.0
HKD2_k127_2041200_0 Amidohydrolase family K01461 - 3.5.1.82 6.645e-298 916.0
HKD2_k127_2041200_1 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 9.076e-286 882.0
HKD2_k127_2041200_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 466.0
HKD2_k127_2041200_3 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 456.0
HKD2_k127_2041200_4 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 422.0
HKD2_k127_2041200_5 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 332.0
HKD2_k127_2041200_6 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003857 271.0
HKD2_k127_2041200_7 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000000000000000002441 231.0
HKD2_k127_2041200_8 integral membrane protein - - - 0.0000000000000000000000000000000001694 134.0
HKD2_k127_2041200_9 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000392 44.0
HKD2_k127_2062874_0 Radical SAM superfamily K11779 - 2.5.1.77 1.649e-230 717.0
HKD2_k127_2062874_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 567.0
HKD2_k127_2062874_2 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 460.0
HKD2_k127_2062874_3 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 365.0
HKD2_k127_2062874_4 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 316.0
HKD2_k127_2062874_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001062 258.0
HKD2_k127_2062874_6 Shikimate kinase K00851 - 2.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000003145 243.0
HKD2_k127_2062874_7 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000367 176.0
HKD2_k127_2062907_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.275e-291 901.0
HKD2_k127_2062907_1 Protein of unknown function (DUF1800) - - - 4.917e-248 775.0
HKD2_k127_2062907_10 Flavin containing amine oxidoreductase K06954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 444.0
HKD2_k127_2062907_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 424.0
HKD2_k127_2062907_12 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 413.0
HKD2_k127_2062907_13 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 408.0
HKD2_k127_2062907_15 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 332.0
HKD2_k127_2062907_16 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K21395 GO:0003674,GO:0005488,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0030246,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 321.0
HKD2_k127_2062907_17 'TIGRFAM RNA polymerase sigma factor, sigma-70 family' K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 292.0
HKD2_k127_2062907_18 Protein of unknown function (DUF1345) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003507 259.0
HKD2_k127_2062907_19 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006568 257.0
HKD2_k127_2062907_2 Major Facilitator Superfamily - - - 1.458e-227 722.0
HKD2_k127_2062907_20 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007528 243.0
HKD2_k127_2062907_21 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005803 242.0
HKD2_k127_2062907_22 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002501 225.0
HKD2_k127_2062907_24 TspO MBR family protein K05770 - - 0.0000000000000000000000000000000000000001124 166.0
HKD2_k127_2062907_25 - K09712,K14475 - - 0.0000000000000000000000000000000000000001253 154.0
HKD2_k127_2062907_27 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000001449 66.0
HKD2_k127_2062907_3 Major facilitator superfamily - - - 8.418e-202 643.0
HKD2_k127_2062907_4 Protein of unknown function (DUF1501) - - - 4.267e-197 617.0
HKD2_k127_2062907_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 571.0
HKD2_k127_2062907_6 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 578.0
HKD2_k127_2062907_7 DNA photolyase K01669 GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 555.0
HKD2_k127_2062907_8 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 497.0
HKD2_k127_2062907_9 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 493.0
HKD2_k127_2087165_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 0.0 1068.0
HKD2_k127_2087165_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 1.472e-301 931.0
HKD2_k127_2087165_10 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 532.0
HKD2_k127_2087165_11 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006713 488.0
HKD2_k127_2087165_12 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 505.0
HKD2_k127_2087165_13 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 416.0
HKD2_k127_2087165_14 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 380.0
HKD2_k127_2087165_15 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 363.0
HKD2_k127_2087165_16 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 337.0
HKD2_k127_2087165_17 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007191 269.0
HKD2_k127_2087165_18 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006877 255.0
HKD2_k127_2087165_19 PFAM MmgE PrpD family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004203 258.0
HKD2_k127_2087165_2 ABC-type Fe3 transport system permease component K02011 - - 4.683e-287 890.0
HKD2_k127_2087165_20 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002276 237.0
HKD2_k127_2087165_21 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000000000000000000000000000000000000000000000000003027 227.0
HKD2_k127_2087165_22 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000005645 216.0
HKD2_k127_2087165_23 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000779 206.0
HKD2_k127_2087165_24 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000001188 168.0
HKD2_k127_2087165_26 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000000002695 134.0
HKD2_k127_2087165_27 Response regulator, receiver - - - 0.00000000000000000000000011 113.0
HKD2_k127_2087165_28 transposase activity - - - 0.0000000000000000003192 95.0
HKD2_k127_2087165_29 DNA replication initiation - - - 0.00000000000002592 84.0
HKD2_k127_2087165_3 Amidase K01426 - 3.5.1.4 3.302e-249 781.0
HKD2_k127_2087165_4 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 4.545e-246 765.0
HKD2_k127_2087165_5 III protein, CoA-transferase family - - - 3.286e-223 695.0
HKD2_k127_2087165_6 Adenylate and Guanylate cyclase catalytic domain - - - 9.606e-222 726.0
HKD2_k127_2087165_7 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 1.618e-207 684.0
HKD2_k127_2087165_8 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 5.991e-198 622.0
HKD2_k127_2087165_9 ABC-type Fe3 transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005496 578.0
HKD2_k127_2103938_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1421.0
HKD2_k127_2103938_1 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 3.095e-213 664.0
HKD2_k127_2103938_10 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 415.0
HKD2_k127_2103938_11 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 409.0
HKD2_k127_2103938_12 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 362.0
HKD2_k127_2103938_13 branched-chain amino acid K01995,K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 356.0
HKD2_k127_2103938_14 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 309.0
HKD2_k127_2103938_15 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 300.0
HKD2_k127_2103938_16 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 298.0
HKD2_k127_2103938_17 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003847 251.0
HKD2_k127_2103938_18 FCD - - - 0.00000000000000000000000000000000000000000000000001174 198.0
HKD2_k127_2103938_2 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 614.0
HKD2_k127_2103938_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 558.0
HKD2_k127_2103938_4 Fumarylacetoacetate (FAA) hydrolase family K05921 - 4.1.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008199 541.0
HKD2_k127_2103938_5 16S RNA G1207 methylase RsmC K00564 - 2.1.1.172 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 482.0
HKD2_k127_2103938_6 C-terminal domain of 1-Cys peroxiredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 447.0
HKD2_k127_2103938_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 443.0
HKD2_k127_2103938_8 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 425.0
HKD2_k127_2103938_9 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 419.0
HKD2_k127_2120254_0 Retinal pigment epithelial membrane protein - - - 1.57e-236 743.0
HKD2_k127_2120254_1 metal-dependent hydrolase of the TIM-barrel fold - - - 7.466e-234 726.0
HKD2_k127_2120254_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 500.0
HKD2_k127_2120254_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 400.0
HKD2_k127_2120254_4 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 342.0
HKD2_k127_2120254_5 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 314.0
HKD2_k127_2120254_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004689 265.0
HKD2_k127_2120254_7 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000003503 222.0
HKD2_k127_2120254_8 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000000000000000001451 143.0
HKD2_k127_226483_0 Transport of potassium into the cell - - - 0.0 1064.0
HKD2_k127_226483_1 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 3.532e-286 900.0
HKD2_k127_226483_10 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 580.0
HKD2_k127_226483_11 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 556.0
HKD2_k127_226483_12 Nitronate monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008679 550.0
HKD2_k127_226483_13 COG1176 ABC-type spermidine putrescine transport system permease component I K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 514.0
HKD2_k127_226483_14 PFAM monooxygenase FAD-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 520.0
HKD2_k127_226483_15 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 520.0
HKD2_k127_226483_16 Ribosomal protein L11 methyltransferase (PrmA) K07320 - 2.1.1.298 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 465.0
HKD2_k127_226483_17 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 463.0
HKD2_k127_226483_18 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 398.0
HKD2_k127_226483_19 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 385.0
HKD2_k127_226483_2 Amidase - - - 1.232e-279 864.0
HKD2_k127_226483_20 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 362.0
HKD2_k127_226483_21 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 356.0
HKD2_k127_226483_22 Flavodoxin-like fold K19784 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 338.0
HKD2_k127_226483_23 AroM protein K14591 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 338.0
HKD2_k127_226483_24 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 331.0
HKD2_k127_226483_25 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 319.0
HKD2_k127_226483_26 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002052 272.0
HKD2_k127_226483_27 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003955 241.0
HKD2_k127_226483_28 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000007342 224.0
HKD2_k127_226483_29 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000000000001438 197.0
HKD2_k127_226483_3 acetyl-coa acetyltransferase - - - 5.683e-229 712.0
HKD2_k127_226483_30 PFAM Usg family protein - - - 0.00000000000000000000000000000000000000000006757 163.0
HKD2_k127_226483_31 CHRD domain - - - 0.00000000000000000000000000000000000000002797 156.0
HKD2_k127_226483_33 Protein of unknown function (DUF3592) - - - 0.0000000000000000000000000000000004503 151.0
HKD2_k127_226483_34 - - - - 0.000000000000000000000000001101 123.0
HKD2_k127_226483_35 Cytochrome c2 K08738 - - 0.0000000000000000000000001093 115.0
HKD2_k127_226483_37 Ketosteroid isomerase-related protein - - - 0.0000000000000000000003295 102.0
HKD2_k127_226483_4 L-carnitine dehydratase bile acid-inducible protein F - - - 1.774e-228 711.0
HKD2_k127_226483_5 cytochrome P-450 - - - 5.069e-219 685.0
HKD2_k127_226483_6 Protein of unknown function (DUF917) K09703 - - 2.669e-210 657.0
HKD2_k127_226483_7 Major Facilitator Superfamily - - - 3.754e-206 646.0
HKD2_k127_226483_8 Protein of unknown function (DUF917) K09703 - - 8.835e-203 641.0
HKD2_k127_226483_9 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02055 - - 1.149e-197 619.0
HKD2_k127_2340234_0 Biotin carboxylase C-terminal domain - - - 0.0 1854.0
HKD2_k127_2340234_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1225.0
HKD2_k127_2340234_10 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 507.0
HKD2_k127_2340234_11 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 473.0
HKD2_k127_2340234_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00038 - 1.1.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 458.0
HKD2_k127_2340234_13 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 459.0
HKD2_k127_2340234_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 391.0
HKD2_k127_2340234_15 COG0655 Multimeric flavodoxin WrbA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008378 288.0
HKD2_k127_2340234_16 Belongs to the CinA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006117 271.0
HKD2_k127_2340234_17 Protein of unknown function (DUF4239) - - - 0.0000000000000000000000000000000000000000000000000000000000003799 220.0
HKD2_k127_2340234_18 Dopa 4,5-dioxygenase family K10253 - - 0.00000000000000000000000000000000000000000000000000000000000955 207.0
HKD2_k127_2340234_19 - - - - 0.00000000000000000000000000000000002956 139.0
HKD2_k127_2340234_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0 1083.0
HKD2_k127_2340234_20 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000008116 97.0
HKD2_k127_2340234_21 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000003473 93.0
HKD2_k127_2340234_22 EamA-like transporter family - - - 0.0000000000008207 80.0
HKD2_k127_2340234_23 mRNA binding K07339 - - 0.00000000002432 68.0
HKD2_k127_2340234_3 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 8.814e-314 967.0
HKD2_k127_2340234_4 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 7.32e-296 917.0
HKD2_k127_2340234_5 Acyl-CoA dehydrogenase, middle domain - - - 2.956e-254 785.0
HKD2_k127_2340234_6 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 2.325e-233 730.0
HKD2_k127_2340234_7 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.046e-217 678.0
HKD2_k127_2340234_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 5.503e-207 646.0
HKD2_k127_2340234_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 561.0
HKD2_k127_2378096_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 3.216e-293 926.0
HKD2_k127_2378096_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 5.218e-247 767.0
HKD2_k127_2378096_10 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 338.0
HKD2_k127_2378096_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 300.0
HKD2_k127_2378096_12 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 292.0
HKD2_k127_2378096_13 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008177 281.0
HKD2_k127_2378096_14 Dual specificity phosphatase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009521 263.0
HKD2_k127_2378096_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000331 252.0
HKD2_k127_2378096_16 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000000000000000006966 227.0
HKD2_k127_2378096_17 NIPSNAP - - - 0.000000000000000000000000000000000000000000005018 165.0
HKD2_k127_2378096_18 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.0000000000000000000000000000001525 141.0
HKD2_k127_2378096_2 lactate metabolic process - - - 9.643e-235 733.0
HKD2_k127_2378096_3 Glycine cleavage system T protein K00605 - 2.1.2.10 3.605e-208 655.0
HKD2_k127_2378096_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 568.0
HKD2_k127_2378096_5 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 568.0
HKD2_k127_2378096_6 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 555.0
HKD2_k127_2378096_7 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 564.0
HKD2_k127_2378096_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 416.0
HKD2_k127_2378096_9 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 411.0
HKD2_k127_242433_0 DNA polymerase K02337 - 2.7.7.7 0.0 1930.0
HKD2_k127_242433_1 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 0.0 1231.0
HKD2_k127_242433_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 6.682e-263 818.0
HKD2_k127_242433_11 Periplasmic binding protein domain K11959 - - 2.691e-251 785.0
HKD2_k127_242433_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 8.533e-251 784.0
HKD2_k127_242433_13 zinc metalloprotease K11749 - - 2.596e-249 774.0
HKD2_k127_242433_14 Permease family K06901 - - 1.979e-225 706.0
HKD2_k127_242433_15 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 1.191e-218 684.0
HKD2_k127_242433_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 3.246e-211 657.0
HKD2_k127_242433_17 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 2.19e-199 634.0
HKD2_k127_242433_18 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 571.0
HKD2_k127_242433_19 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 571.0
HKD2_k127_242433_2 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0 1128.0
HKD2_k127_242433_20 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 512.0
HKD2_k127_242433_21 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 506.0
HKD2_k127_242433_22 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 487.0
HKD2_k127_242433_23 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 441.0
HKD2_k127_242433_24 Branched-chain amino acid ATP-binding cassette transporter K01995,K11962 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 428.0
HKD2_k127_242433_25 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 417.0
HKD2_k127_242433_26 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 400.0
HKD2_k127_242433_27 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 374.0
HKD2_k127_242433_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 364.0
HKD2_k127_242433_29 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 354.0
HKD2_k127_242433_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1118.0
HKD2_k127_242433_30 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 339.0
HKD2_k127_242433_31 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 320.0
HKD2_k127_242433_32 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 312.0
HKD2_k127_242433_33 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 331.0
HKD2_k127_242433_34 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 295.0
HKD2_k127_242433_35 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 286.0
HKD2_k127_242433_36 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003202 297.0
HKD2_k127_242433_37 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000003571 263.0
HKD2_k127_242433_38 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000003169 241.0
HKD2_k127_242433_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000000000001206 170.0
HKD2_k127_242433_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.925e-310 959.0
HKD2_k127_242433_40 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000981 167.0
HKD2_k127_242433_41 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000000000000003176 156.0
HKD2_k127_242433_42 Protein of unknown function (DUF1467) - - - 0.000000000000000000000000000000000001419 139.0
HKD2_k127_242433_5 hydrolase of the metallo-beta-lactamase superfamily K12574 - - 2.633e-310 968.0
HKD2_k127_242433_6 Belongs to the amidase family K01426 - 3.5.1.4 9.1e-307 943.0
HKD2_k127_242433_7 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 6.062e-297 914.0
HKD2_k127_242433_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.504e-281 865.0
HKD2_k127_242433_9 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 4.951e-264 819.0
HKD2_k127_2495751_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0 1050.0
HKD2_k127_2495751_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 2.476e-253 786.0
HKD2_k127_2495751_2 Belongs to the CarA family K01956 - 6.3.5.5 3.471e-247 764.0
HKD2_k127_2495751_3 Belongs to the CarB family K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002368 271.0
HKD2_k127_2495751_4 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000000000000000000003011 235.0
HKD2_k127_249700_0 Cysteine-rich domain - - - 2.86e-272 840.0
HKD2_k127_249700_1 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 1.54e-232 724.0
HKD2_k127_249700_10 Belongs to the Fur family K09826 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002346 258.0
HKD2_k127_249700_11 Dioxygenase K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000001856 235.0
HKD2_k127_249700_12 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000001976 216.0
HKD2_k127_249700_13 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000000000002632 168.0
HKD2_k127_249700_14 energy transducer activity K03832 - - 0.0000000000000000000000000000000000005535 156.0
HKD2_k127_249700_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 1.512e-196 616.0
HKD2_k127_249700_3 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 482.0
HKD2_k127_249700_4 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 458.0
HKD2_k127_249700_5 Protein of unknown function (DUF3501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 334.0
HKD2_k127_249700_6 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 331.0
HKD2_k127_249700_7 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 326.0
HKD2_k127_249700_8 protein conserved in bacteria K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 291.0
HKD2_k127_249700_9 COG1592 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000134 279.0
HKD2_k127_2524086_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.701e-293 906.0
HKD2_k127_2524086_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 1.834e-287 888.0
HKD2_k127_2524086_10 Belongs to the ABC transporter superfamily K02031 - - 7.094e-197 620.0
HKD2_k127_2524086_11 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000956 602.0
HKD2_k127_2524086_12 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 552.0
HKD2_k127_2524086_13 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 539.0
HKD2_k127_2524086_14 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008692 535.0
HKD2_k127_2524086_15 N-terminal TM domain of oligopeptide transport permease C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 534.0
HKD2_k127_2524086_16 branched-chain amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 425.0
HKD2_k127_2524086_17 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 414.0
HKD2_k127_2524086_18 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 401.0
HKD2_k127_2524086_19 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 389.0
HKD2_k127_2524086_2 Class-II DAHP synthetase family - - - 1.726e-286 891.0
HKD2_k127_2524086_20 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 351.0
HKD2_k127_2524086_21 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 358.0
HKD2_k127_2524086_22 Ca2 -binding protein (EF-Hand superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006736 316.0
HKD2_k127_2524086_23 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008543 308.0
HKD2_k127_2524086_24 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 308.0
HKD2_k127_2524086_25 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000001228 223.0
HKD2_k127_2524086_26 Domain of unknown function (DUF4439) - - - 0.000000000000000000000000000000000000000000000000000000000006406 213.0
HKD2_k127_2524086_28 EF-hand domain pair - - - 0.00000000000000000000000000000000000000000000000000000001647 201.0
HKD2_k127_2524086_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 6.954e-262 812.0
HKD2_k127_2524086_30 Cytochrome c K08738 - - 0.0000000000000000000000000000002046 139.0
HKD2_k127_2524086_4 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 3.353e-234 726.0
HKD2_k127_2524086_5 5-aminolevulinic acid synthase K00643 - 2.3.1.37 3.656e-226 719.0
HKD2_k127_2524086_6 Phosphate acyltransferases - - - 4.156e-224 736.0
HKD2_k127_2524086_7 Receptor family ligand binding region - - - 8.128e-222 692.0
HKD2_k127_2524086_8 Receptor family ligand binding region - - - 2.271e-220 688.0
HKD2_k127_2524086_9 Receptor family ligand binding region - - - 4.061e-201 634.0
HKD2_k127_2577854_0 Histidine kinase K07646 - 2.7.13.3 0.0 1365.0
HKD2_k127_2577854_1 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.0 1183.0
HKD2_k127_2577854_10 Integral membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 395.0
HKD2_k127_2577854_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 383.0
HKD2_k127_2577854_12 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 376.0
HKD2_k127_2577854_13 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 305.0
HKD2_k127_2577854_14 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001043 259.0
HKD2_k127_2577854_15 peroxiredoxin activity K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000005913 235.0
HKD2_k127_2577854_16 Copper resistance protein B precursor (CopB) K07233 - - 0.0000000000000000000000000000000000000000000000000000000000000002343 240.0
HKD2_k127_2577854_17 Metal-sensitive transcriptional repressor - - - 0.0000000000000000000000000000000000000000000832 164.0
HKD2_k127_2577854_18 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000428 133.0
HKD2_k127_2577854_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1045.0
HKD2_k127_2577854_21 LTXXQ motif family protein - - - 0.0000000000000000000000000001075 123.0
HKD2_k127_2577854_22 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000001238 123.0
HKD2_k127_2577854_23 - - - - 0.0000000000000000000000004829 116.0
HKD2_k127_2577854_25 Copper binding periplasmic protein CusF - - - 0.000000000000000003616 95.0
HKD2_k127_2577854_26 Protein of unknown function (DUF2933) - - - 0.000000000000000007597 86.0
HKD2_k127_2577854_3 Transport of potassium into the cell K03549 - - 0.0 1001.0
HKD2_k127_2577854_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.011e-291 904.0
HKD2_k127_2577854_5 Multicopper oxidase - - - 4.175e-241 767.0
HKD2_k127_2577854_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 7.963e-195 612.0
HKD2_k127_2577854_7 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 551.0
HKD2_k127_2577854_8 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 541.0
HKD2_k127_2577854_9 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 430.0
HKD2_k127_2612200_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.061e-233 724.0
HKD2_k127_2612200_1 COG0665 Glycine D-amino acid oxidases (deaminating) K00285,K21060 - 1.4.5.1 1.547e-228 711.0
HKD2_k127_2612200_10 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000002987 169.0
HKD2_k127_2612200_11 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0003134 46.0
HKD2_k127_2612200_2 Aminotransferase class-V - - - 5.313e-210 657.0
HKD2_k127_2612200_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 422.0
HKD2_k127_2612200_4 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 407.0
HKD2_k127_2612200_5 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 373.0
HKD2_k127_2612200_6 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 302.0
HKD2_k127_2612200_7 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000003533 213.0
HKD2_k127_2612200_8 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.00000000000000000000000000000000000000000000002516 173.0
HKD2_k127_2612200_9 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000002477 171.0
HKD2_k127_2625701_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1384.0
HKD2_k127_2625701_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.449e-236 732.0
HKD2_k127_2625701_10 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000000000000000000005419 128.0
HKD2_k127_2625701_11 alpha beta - - - 0.0000000000000000000000000000138 132.0
HKD2_k127_2625701_12 Phosphopantetheine attachment site K02078 - - 0.00000000000001519 80.0
HKD2_k127_2625701_13 MaoC like domain - - - 0.00000001357 65.0
HKD2_k127_2625701_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 1.238e-219 685.0
HKD2_k127_2625701_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K08261,K21620 - 1.1.1.16,1.1.99.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 419.0
HKD2_k127_2625701_4 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 401.0
HKD2_k127_2625701_6 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 302.0
HKD2_k127_2625701_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001079 267.0
HKD2_k127_2625701_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000000000000000006994 216.0
HKD2_k127_2625701_9 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.000000000000000000000000000000000000000000000000000000000000033 215.0
HKD2_k127_2633230_0 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.0 1211.0
HKD2_k127_2633230_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0 1079.0
HKD2_k127_2633230_10 MlaD protein K02067,K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 538.0
HKD2_k127_2633230_11 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 537.0
HKD2_k127_2633230_12 Dehydratase K08678 - 4.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 526.0
HKD2_k127_2633230_13 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 524.0
HKD2_k127_2633230_14 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 516.0
HKD2_k127_2633230_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 522.0
HKD2_k127_2633230_16 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000672 480.0
HKD2_k127_2633230_17 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 439.0
HKD2_k127_2633230_18 ATPases associated with a variety of cellular activities K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 451.0
HKD2_k127_2633230_19 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 422.0
HKD2_k127_2633230_2 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0 1072.0
HKD2_k127_2633230_20 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 420.0
HKD2_k127_2633230_21 ABC-type transport auxiliary lipoprotein component K18480 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 392.0
HKD2_k127_2633230_22 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 365.0
HKD2_k127_2633230_24 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 350.0
HKD2_k127_2633230_25 NAD(P)H-binding K07118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001074 280.0
HKD2_k127_2633230_26 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.00000000000000000000000000000000000000000000000000000000000000000000002737 250.0
HKD2_k127_2633230_28 NfeD-like C-terminal, partner-binding K07340 - - 0.00000000000000000000000000000000000000000000000000000000007413 207.0
HKD2_k127_2633230_29 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000005139 202.0
HKD2_k127_2633230_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 7.9e-289 893.0
HKD2_k127_2633230_30 Protein of unknown function (DUF3987) - - - 0.0000000000000000000000000000000006991 147.0
HKD2_k127_2633230_31 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000004056 89.0
HKD2_k127_2633230_32 Alpha/beta hydrolase family - - - 0.000000000009138 73.0
HKD2_k127_2633230_33 - - - - 0.00000001173 68.0
HKD2_k127_2633230_34 - - - - 0.0000004119 54.0
HKD2_k127_2633230_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596 - 4.1.1.64 5.849e-240 756.0
HKD2_k127_2633230_5 Phosphotransferase enzyme family - - - 1.922e-222 691.0
HKD2_k127_2633230_6 COG0477 Permeases of the major facilitator superfamily - - - 9.238e-211 660.0
HKD2_k127_2633230_7 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 1.245e-202 633.0
HKD2_k127_2633230_8 Acetamidase/Formamidase family - - - 2.89e-197 620.0
HKD2_k127_2633230_9 Permease MlaE K02066 - - 2.833e-195 623.0
HKD2_k127_2634486_0 ABC-type sugar transport system, periplasmic component K02027 - - 1.492e-217 699.0
HKD2_k127_2634486_1 PFAM type III effector Hrp-dependent outers K21948 - 2.7.1.217 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 614.0
HKD2_k127_2634486_2 ABC-type sugar K02025,K10237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 491.0
HKD2_k127_2634486_3 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 458.0
HKD2_k127_2634486_4 2-hydroxy-3-oxopropionate reductase K00020,K08319 - 1.1.1.31,1.1.1.411 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 449.0
HKD2_k127_2634486_5 to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 427.0
HKD2_k127_2634486_6 Class II aldolase K01628,K22130 - 4.1.1.104,4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 379.0
HKD2_k127_2634486_7 FCD K05799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009207 266.0
HKD2_k127_2634486_8 PFAM Binding-protein-dependent transport system inner membrane component K02026,K10238 - - 0.0000000000000000000000000000000000000000002689 160.0
HKD2_k127_2634486_9 Nad-dependent epimerase dehydratase K22025 - 1.1.1.410 0.0000000000000000000000001441 108.0
HKD2_k127_2637626_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.6e-313 963.0
HKD2_k127_2637626_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 1.844e-241 751.0
HKD2_k127_2637626_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 3.205e-204 642.0
HKD2_k127_2637626_3 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 621.0
HKD2_k127_2637626_4 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 599.0
HKD2_k127_2637626_5 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 286.0
HKD2_k127_2637626_6 Protein of unknown function (DUF3035) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006949 277.0
HKD2_k127_2637641_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1745.0
HKD2_k127_2637641_1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.0 1139.0
HKD2_k127_2637641_10 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 386.0
HKD2_k127_2637641_2 Histidine kinase - - - 1.476e-209 659.0
HKD2_k127_2637641_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion K15727 - - 2.931e-195 616.0
HKD2_k127_2637641_4 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 623.0
HKD2_k127_2637641_5 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 558.0
HKD2_k127_2637641_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 497.0
HKD2_k127_2637641_7 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 493.0
HKD2_k127_2637641_8 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 486.0
HKD2_k127_2637641_9 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 438.0
HKD2_k127_2637715_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01847 - 5.4.99.2 0.0 1321.0
HKD2_k127_2637715_1 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 0.0 1030.0
HKD2_k127_2637715_2 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 527.0
HKD2_k127_2637715_3 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 528.0
HKD2_k127_2637715_4 alpha/beta hydrolase fold K01066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 521.0
HKD2_k127_2637715_5 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 460.0
HKD2_k127_2637715_6 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 452.0
HKD2_k127_2637715_8 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 342.0
HKD2_k127_2673041_0 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 479.0
HKD2_k127_2673041_1 nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 411.0
HKD2_k127_2673041_2 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 393.0
HKD2_k127_2673041_3 Nitrate reductase delta subunit K00373 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 383.0
HKD2_k127_2673041_4 Nitrate reductase beta subunit K00371 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 349.0
HKD2_k127_2673041_5 Protein of unknown function (DUF2478) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009267 262.0
HKD2_k127_2673041_6 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000001973 208.0
HKD2_k127_2673041_7 - - - - 0.0000000000000000000000000000000000000000000000004141 179.0
HKD2_k127_2673041_8 - - - - 0.0000000000000000000000000000000157 129.0
HKD2_k127_2705268_0 Fungalysin/Thermolysin Propeptide Motif K01399 - 3.4.24.26 3.55e-266 830.0
HKD2_k127_2705268_1 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 550.0
HKD2_k127_2705268_2 oxidoreductase activity K00505 - 1.14.18.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 495.0
HKD2_k127_2705268_3 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 464.0
HKD2_k127_2705268_4 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 309.0
HKD2_k127_2705268_5 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 285.0
HKD2_k127_2705268_6 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000000000000883 205.0
HKD2_k127_2705268_7 - - - - 0.0000000006524 67.0
HKD2_k127_2709916_0 urea carboxylase K01941 - 6.3.4.6 0.0 2222.0
HKD2_k127_2709916_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01457 - 3.5.1.54 4.111e-261 816.0
HKD2_k127_2709916_2 urea carboxylase-associated protein 1 K09967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 436.0
HKD2_k127_2709916_3 TIGRFAM Urea carboxylase-associated protein 2 K09967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 411.0
HKD2_k127_2709916_4 Fusaric acid resistance protein-like - - - 0.000000000000000000000000000000000000000000009671 168.0
HKD2_k127_2721909_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 516.0
HKD2_k127_2721909_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 495.0
HKD2_k127_2721909_10 acid phosphatase activity - - - 0.000005822 60.0
HKD2_k127_2721909_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 436.0
HKD2_k127_2721909_3 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 321.0
HKD2_k127_2721909_4 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000117 315.0
HKD2_k127_2721909_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002413 286.0
HKD2_k127_2721909_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008645 286.0
HKD2_k127_2721909_7 abc transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000004739 253.0
HKD2_k127_2721909_8 ABC transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000005448 232.0
HKD2_k127_2721909_9 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000002511 208.0
HKD2_k127_2725158_0 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 0.0 1555.0
HKD2_k127_2725158_1 Precorrin-6Y C5,15-methyltransferase K00595 - 2.1.1.132 1.973e-195 616.0
HKD2_k127_2725158_10 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 321.0
HKD2_k127_2725158_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001668 281.0
HKD2_k127_2725158_12 Precorrin-6x reductase CbiJ/CobK K05895 - 1.3.1.106,1.3.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000002833 266.0
HKD2_k127_2725158_13 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000002353 212.0
HKD2_k127_2725158_14 cobalamin biosynthesis protein K02189 - 3.7.1.12 0.000000000000000000000000859 120.0
HKD2_k127_2725158_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 603.0
HKD2_k127_2725158_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 552.0
HKD2_k127_2725158_4 Precorrin-4 K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 441.0
HKD2_k127_2725158_5 Precorrin-2 K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 437.0
HKD2_k127_2725158_6 Nitrite/Sulfite reductase ferredoxin-like half domain K02229 - 1.14.13.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 397.0
HKD2_k127_2725158_7 Nitroreductase family K04719 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016491,GO:0016705,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 394.0
HKD2_k127_2725158_8 Precorrin-3B K05934,K13541 - 2.1.1.131,3.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 375.0
HKD2_k127_2725158_9 Tetrapyrrole (Corrin/Porphyrin) Methylases K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 325.0
HKD2_k127_27376_0 Acyclic terpene utilisation family protein AtuA - - - 0.0 1064.0
HKD2_k127_27376_1 His Kinase A (phosphoacceptor) domain - - - 3.654e-268 843.0
HKD2_k127_27376_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 352.0
HKD2_k127_27376_11 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 301.0
HKD2_k127_27376_12 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001838 280.0
HKD2_k127_27376_13 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002188 287.0
HKD2_k127_27376_14 Uncharacterised protein family (UPF0262) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005573 265.0
HKD2_k127_27376_15 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000003735 261.0
HKD2_k127_27376_16 Bacterial regulatory helix-turn-helix protein, lysR family K02623 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001726 259.0
HKD2_k127_27376_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002722 246.0
HKD2_k127_27376_18 Protein of unknown function (DUF2948) - - - 0.0000000000000000000000000000000000000000000000000000000000000000009142 232.0
HKD2_k127_27376_19 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000000000003806 208.0
HKD2_k127_27376_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 4.572e-237 740.0
HKD2_k127_27376_20 Alpha beta hydrolase K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000001178 180.0
HKD2_k127_27376_21 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000002031 147.0
HKD2_k127_27376_23 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000000000000008084 111.0
HKD2_k127_27376_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 1.434e-226 711.0
HKD2_k127_27376_4 COG1530 Ribonucleases G and E K08300,K08301 - 3.1.26.12 1.486e-216 681.0
HKD2_k127_27376_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 423.0
HKD2_k127_27376_6 thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 437.0
HKD2_k127_27376_7 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 417.0
HKD2_k127_27376_8 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 399.0
HKD2_k127_27376_9 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007173 374.0
HKD2_k127_2748953_0 Belongs to the aldehyde dehydrogenase family - - - 5.8e-278 864.0
HKD2_k127_2748953_1 Bacterial extracellular solute-binding protein K02027 - - 3.357e-266 825.0
HKD2_k127_2748953_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008102 573.0
HKD2_k127_2748953_11 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009353 581.0
HKD2_k127_2748953_12 ABC transporter substrate-binding protein K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 569.0
HKD2_k127_2748953_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 552.0
HKD2_k127_2748953_14 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 584.0
HKD2_k127_2748953_15 'PFAM Taurine catabolism dioxygenase TauD, TfdA family' - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 536.0
HKD2_k127_2748953_16 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 536.0
HKD2_k127_2748953_17 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 521.0
HKD2_k127_2748953_18 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 521.0
HKD2_k127_2748953_19 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 508.0
HKD2_k127_2748953_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 7.173e-238 737.0
HKD2_k127_2748953_20 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 507.0
HKD2_k127_2748953_21 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 501.0
HKD2_k127_2748953_22 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510,K12660 - 4.1.2.52,4.1.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 482.0
HKD2_k127_2748953_23 Thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009567 466.0
HKD2_k127_2748953_24 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008343 459.0
HKD2_k127_2748953_25 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 439.0
HKD2_k127_2748953_26 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 425.0
HKD2_k127_2748953_27 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 405.0
HKD2_k127_2748953_28 Belongs to the mandelate racemase muconate lactonizing enzyme family K01856 - 5.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 408.0
HKD2_k127_2748953_29 DJ-1/PfpI family K18199 - 4.2.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 374.0
HKD2_k127_2748953_3 Beta-lactamase - - - 7.403e-238 738.0
HKD2_k127_2748953_30 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 362.0
HKD2_k127_2748953_31 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 363.0
HKD2_k127_2748953_32 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 361.0
HKD2_k127_2748953_33 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008495 325.0
HKD2_k127_2748953_34 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 319.0
HKD2_k127_2748953_35 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008886 327.0
HKD2_k127_2748953_36 Steryl acetyl hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 302.0
HKD2_k127_2748953_37 ATPases associated with a variety of cellular activities K02028,K02029,K09972,K10004 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 295.0
HKD2_k127_2748953_38 Bacterial periplasmic substrate-binding proteins K10001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004312 267.0
HKD2_k127_2748953_39 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002263 253.0
HKD2_k127_2748953_4 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.224e-232 732.0
HKD2_k127_2748953_40 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008214 243.0
HKD2_k127_2748953_41 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003971 240.0
HKD2_k127_2748953_42 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000003684 245.0
HKD2_k127_2748953_43 PFAM NIPSNAP family containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001231 224.0
HKD2_k127_2748953_44 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.00000000000000000000000000000000000000000000000000000000000000004776 229.0
HKD2_k127_2748953_45 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000376 210.0
HKD2_k127_2748953_46 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000000000000000000000000000000000000000000000000004871 200.0
HKD2_k127_2748953_48 Bacterial periplasmic substrate-binding proteins - - - 0.00000000000000000000000000000000000000000000000000002075 200.0
HKD2_k127_2748953_49 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000003371 198.0
HKD2_k127_2748953_5 Major Facilitator Superfamily - - - 3.711e-229 716.0
HKD2_k127_2748953_50 bacterial (prokaryotic) histone like domain - - - 0.000000000000000000000000000000000000000000000006435 174.0
HKD2_k127_2748953_51 Protein conserved in bacteria K09984 - - 0.00000000000000000000000000000000000000000000006505 172.0
HKD2_k127_2748953_52 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000004638 179.0
HKD2_k127_2748953_53 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000000000000000000000000000000000004854 157.0
HKD2_k127_2748953_54 - - - - 0.0000000000000000000000000000000000000001451 162.0
HKD2_k127_2748953_55 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000006462 139.0
HKD2_k127_2748953_57 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000004907 97.0
HKD2_k127_2748953_58 PFAM BNR Asp-box repeat - - - 0.00000000002002 79.0
HKD2_k127_2748953_6 Amidase K02433 - 6.3.5.6,6.3.5.7 6.944e-228 715.0
HKD2_k127_2748953_60 Putative peptidoglycan binding domain - - - 0.00006321 55.0
HKD2_k127_2748953_7 Beta-lactamase K18372 - - 1.536e-212 664.0
HKD2_k127_2748953_8 Luciferase-like monooxygenase - - - 1.042e-195 614.0
HKD2_k127_2748953_9 Polysaccharide deacetylase - - - 1.051e-195 610.0
HKD2_k127_2773254_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1849.0
HKD2_k127_2773254_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1626.0
HKD2_k127_2773254_10 polysaccharide export K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 479.0
HKD2_k127_2773254_11 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 447.0
HKD2_k127_2773254_12 PFAM secretion protein HlyD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 430.0
HKD2_k127_2773254_13 COG2873 O-acetylhomoserine sulfhydrylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 414.0
HKD2_k127_2773254_14 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis K00720 - 2.4.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 412.0
HKD2_k127_2773254_15 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008705 371.0
HKD2_k127_2773254_16 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 370.0
HKD2_k127_2773254_17 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 346.0
HKD2_k127_2773254_18 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 300.0
HKD2_k127_2773254_19 flavin adenine dinucleotide binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 303.0
HKD2_k127_2773254_2 COG0616 Periplasmic serine proteases (ClpP class) K04773 - - 4.164e-281 874.0
HKD2_k127_2773254_20 Single-strand binding protein family K03111 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002891 270.0
HKD2_k127_2773254_21 phosphatase activity K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000009403 257.0
HKD2_k127_2773254_25 transport, permease protein K09690 - - 0.00000000009686 72.0
HKD2_k127_2773254_3 AAA domain K07028 - - 6.102e-227 718.0
HKD2_k127_2773254_4 Major Facilitator Superfamily - - - 8.927e-217 679.0
HKD2_k127_2773254_5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 9.99e-216 673.0
HKD2_k127_2773254_6 efflux transmembrane transporter activity K02004 - - 2.346e-194 630.0
HKD2_k127_2773254_7 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 541.0
HKD2_k127_2773254_8 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 497.0
HKD2_k127_2773254_9 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 468.0
HKD2_k127_2792619_0 Chain length determinant protein K16554 - - 0.0 1067.0
HKD2_k127_2792619_1 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 2.115e-237 742.0
HKD2_k127_2792619_10 Transcriptional regulatory protein, C terminal K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 433.0
HKD2_k127_2792619_11 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 392.0
HKD2_k127_2792619_12 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377,K16554 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 385.0
HKD2_k127_2792619_13 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 337.0
HKD2_k127_2792619_14 COG1596 Periplasmic protein involved in polysaccharide export K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001884 277.0
HKD2_k127_2792619_15 Pectate lyase superfamily protein - - - 0.00000004502 66.0
HKD2_k127_2792619_2 Histidine kinase-like ATPases K14980 - 2.7.13.3 2.147e-220 696.0
HKD2_k127_2792619_3 COG2148 Sugar transferases involved in lipopolysaccharide synthesis K03606,K20997 - - 1.372e-211 668.0
HKD2_k127_2792619_4 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 8.01e-207 656.0
HKD2_k127_2792619_5 Glycosyl transferase 4-like domain K03208 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006256 608.0
HKD2_k127_2792619_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 604.0
HKD2_k127_2792619_7 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 592.0
HKD2_k127_2792619_8 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 474.0
HKD2_k127_2792619_9 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 451.0
HKD2_k127_2886371_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1188.0
HKD2_k127_2886371_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 5.25e-201 629.0
HKD2_k127_2886371_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 595.0
HKD2_k127_2886371_3 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 598.0
HKD2_k127_2886371_4 Protein conserved in bacteria K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 510.0
HKD2_k127_2886371_5 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 451.0
HKD2_k127_2886371_6 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 299.0
HKD2_k127_2886371_7 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000000008449 257.0
HKD2_k127_2886371_8 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007808 241.0
HKD2_k127_2886371_9 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000000000000000000000000000003328 174.0
HKD2_k127_2889091_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1294.0
HKD2_k127_2889091_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 1.849e-246 766.0
HKD2_k127_2889091_10 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 304.0
HKD2_k127_2889091_11 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 295.0
HKD2_k127_2889091_12 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.00000000000000000000000000000000000000000000000000000000000001808 237.0
HKD2_k127_2889091_13 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 - - 0.00000000000000000000000000000000000000000000000000000000002644 222.0
HKD2_k127_2889091_14 transport system permease component - - - 0.000000000000000000000000000000000000000000000003852 191.0
HKD2_k127_2889091_15 - - - - 0.00000000000000000000009086 98.0
HKD2_k127_2889091_2 monooxygenase K09018 - 1.14.99.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 557.0
HKD2_k127_2889091_3 Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate K09018 - 1.14.99.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 495.0
HKD2_k127_2889091_4 NIPSNAP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 388.0
HKD2_k127_2889091_5 ABC-type dipeptide transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 412.0
HKD2_k127_2889091_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 328.0
HKD2_k127_2889091_7 N-terminal TM domain of oligopeptide transport permease C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 318.0
HKD2_k127_2889091_8 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 296.0
HKD2_k127_2889091_9 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007336 312.0
HKD2_k127_2907100_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1504.0
HKD2_k127_2907100_1 - - - - 3.136e-206 647.0
HKD2_k127_2907100_10 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 352.0
HKD2_k127_2907100_11 - - - - 0.000000000000000000000000000000000000000000001442 169.0
HKD2_k127_2907100_12 Haem-degrading - - - 0.000000000000000000000000000000000000003273 152.0
HKD2_k127_2907100_2 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 4.372e-198 623.0
HKD2_k127_2907100_3 4Fe-4S dicluster domain K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007672 587.0
HKD2_k127_2907100_4 Allophanate hydrolase subunit 2 K01457 - 3.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 547.0
HKD2_k127_2907100_5 LamB/YcsF family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 475.0
HKD2_k127_2907100_6 Prokaryotic cytochrome b561 K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 408.0
HKD2_k127_2907100_7 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051 359.0
HKD2_k127_2907100_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 366.0
HKD2_k127_2907100_9 Allophanate hydrolase subunit 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 346.0
HKD2_k127_2938061_0 Receptor family ligand binding region - - - 2.809e-224 699.0
HKD2_k127_2938061_1 HI0933-like protein K07007 - - 2.456e-206 656.0
HKD2_k127_2938061_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 562.0
HKD2_k127_2938061_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 499.0
HKD2_k127_2938061_4 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 428.0
HKD2_k127_2938061_5 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 392.0
HKD2_k127_2938061_6 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001067 263.0
HKD2_k127_2938061_7 Belongs to the ABC transporter superfamily K01996 GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000004034 227.0
HKD2_k127_2938061_8 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000005126 59.0
HKD2_k127_300581_0 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.0 2561.0
HKD2_k127_300581_1 COG0513 Superfamily II DNA and RNA helicases K17675 - 3.6.4.13 0.0 1684.0
HKD2_k127_300581_10 Amidase K02433 - 6.3.5.6,6.3.5.7 7.24e-238 741.0
HKD2_k127_300581_11 CoA-transferase family III K01796 - 5.1.99.4 1.45e-230 718.0
HKD2_k127_300581_12 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 4.04e-219 685.0
HKD2_k127_300581_13 Cupin domain - - - 2.495e-213 665.0
HKD2_k127_300581_14 serine-type peptidase activity - - - 4.67e-213 670.0
HKD2_k127_300581_15 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 2.192e-206 644.0
HKD2_k127_300581_16 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 7.674e-196 612.0
HKD2_k127_300581_17 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 584.0
HKD2_k127_300581_18 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 567.0
HKD2_k127_300581_19 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008565 572.0
HKD2_k127_300581_2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1668.0
HKD2_k127_300581_20 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006867 519.0
HKD2_k127_300581_21 de-polymerase K05973 - 3.1.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 499.0
HKD2_k127_300581_22 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 482.0
HKD2_k127_300581_23 ABC 3 transport family K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 481.0
HKD2_k127_300581_24 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 481.0
HKD2_k127_300581_25 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 480.0
HKD2_k127_300581_26 Alpha beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 479.0
HKD2_k127_300581_27 ATPases associated with a variety of cellular activities K02074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 447.0
HKD2_k127_300581_28 cell division K05803 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0030674,GO:0044464,GO:0051301,GO:0060090,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 444.0
HKD2_k127_300581_29 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 429.0
HKD2_k127_300581_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1257.0
HKD2_k127_300581_30 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 442.0
HKD2_k127_300581_31 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009778 422.0
HKD2_k127_300581_32 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 418.0
HKD2_k127_300581_33 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 383.0
HKD2_k127_300581_34 Protein of unknown function (DUF1223) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 370.0
HKD2_k127_300581_35 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 355.0
HKD2_k127_300581_36 Etoposide-induced protein 2.4 (EI24) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 355.0
HKD2_k127_300581_37 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 353.0
HKD2_k127_300581_38 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 345.0
HKD2_k127_300581_39 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 333.0
HKD2_k127_300581_4 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1151.0
HKD2_k127_300581_40 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 329.0
HKD2_k127_300581_41 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 297.0
HKD2_k127_300581_42 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 293.0
HKD2_k127_300581_43 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006445 305.0
HKD2_k127_300581_44 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009241 283.0
HKD2_k127_300581_45 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004982 286.0
HKD2_k127_300581_46 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005767 265.0
HKD2_k127_300581_47 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005915 261.0
HKD2_k127_300581_48 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000002696 248.0
HKD2_k127_300581_49 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006866 256.0
HKD2_k127_300581_5 RQC K03654 - 3.6.4.12 0.0 1002.0
HKD2_k127_300581_50 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000002211 256.0
HKD2_k127_300581_51 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000005614 217.0
HKD2_k127_300581_52 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000003001 216.0
HKD2_k127_300581_53 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000000000000000000000002652 200.0
HKD2_k127_300581_55 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.0000000000000000000000000000000000000005865 149.0
HKD2_k127_300581_56 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000008202 150.0
HKD2_k127_300581_57 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000001665 130.0
HKD2_k127_300581_6 amine dehydrogenase activity - - - 6.659e-313 964.0
HKD2_k127_300581_60 transcriptional regulator K07736 - - 0.00000000000002999 77.0
HKD2_k127_300581_61 Cupin 2, conserved barrel domain protein - - - 0.000000000000579 68.0
HKD2_k127_300581_62 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00002353 55.0
HKD2_k127_300581_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 3.172e-283 876.0
HKD2_k127_300581_8 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 1.137e-279 871.0
HKD2_k127_300581_9 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 9.017e-274 844.0
HKD2_k127_3014804_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 2.882e-248 776.0
HKD2_k127_3014804_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 6.099e-239 740.0
HKD2_k127_3014804_10 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 395.0
HKD2_k127_3014804_11 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 369.0
HKD2_k127_3014804_12 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 373.0
HKD2_k127_3014804_13 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 354.0
HKD2_k127_3014804_14 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 331.0
HKD2_k127_3014804_15 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 331.0
HKD2_k127_3014804_16 branched-chain amino acid transport K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 343.0
HKD2_k127_3014804_17 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 318.0
HKD2_k127_3014804_18 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 297.0
HKD2_k127_3014804_19 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006186 272.0
HKD2_k127_3014804_2 Peptidase dimerisation domain K01295 - 3.4.17.11 1.326e-224 698.0
HKD2_k127_3014804_20 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005413 262.0
HKD2_k127_3014804_21 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005799 251.0
HKD2_k127_3014804_22 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000008128 241.0
HKD2_k127_3014804_23 - - - - 0.0000000000000000000000000000000000000000000000000000000000736 220.0
HKD2_k127_3014804_24 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000004787 203.0
HKD2_k127_3014804_25 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000005285 188.0
HKD2_k127_3014804_26 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.00000000000000000000000000000000000000000005717 175.0
HKD2_k127_3014804_27 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000004149 175.0
HKD2_k127_3014804_28 - - - - 0.000000000000000000000000000000000004357 148.0
HKD2_k127_3014804_29 GYD domain - - - 0.0000000000000000000000000009376 116.0
HKD2_k127_3014804_3 Adenylate and Guanylate cyclase catalytic domain - - - 4.277e-223 733.0
HKD2_k127_3014804_30 Transcriptional regulator - - - 0.0000000000000000000002754 114.0
HKD2_k127_3014804_31 serine threonine protein kinase K08282 - 2.7.11.1 0.000000000000108 83.0
HKD2_k127_3014804_32 MaoC like domain - - - 0.000000000005849 67.0
HKD2_k127_3014804_33 Protein of unknown function (DUF4231) - - - 0.00000000001699 73.0
HKD2_k127_3014804_34 Carboxymuconolactone decarboxylase family - - - 0.00001498 54.0
HKD2_k127_3014804_35 - - - - 0.00005057 53.0
HKD2_k127_3014804_4 N-terminal half of MaoC dehydratase - - - 6.512e-212 679.0
HKD2_k127_3014804_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 564.0
HKD2_k127_3014804_6 Glutathione S-transferase, C-terminal domain K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 511.0
HKD2_k127_3014804_7 Creatinase/Prolidase N-terminal domain K08688 - 3.5.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009895 501.0
HKD2_k127_3014804_8 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 452.0
HKD2_k127_3014804_9 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 436.0
HKD2_k127_309593_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 0.0 1137.0
HKD2_k127_309593_1 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 9.302e-307 944.0
HKD2_k127_309593_2 - - - - 0.000000000000000000000000000000000000000000000623 180.0
HKD2_k127_309593_3 RQC K03654 - 3.6.4.12 0.000000000000421 70.0
HKD2_k127_3105380_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.0 1828.0
HKD2_k127_3105380_1 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 429.0
HKD2_k127_3105380_2 Transketolase, pyrimidine binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000287 214.0
HKD2_k127_3105380_3 Penicillin-binding protein 5, C-terminal domain K07258 - 3.4.16.4 0.000000000000000000000000000000000008527 138.0
HKD2_k127_315095_0 Uncharacterised protein family (UPF0182) K09118 - - 0.0 1273.0
HKD2_k127_315095_1 AMP-binding enzyme C-terminal domain K01895,K08295 - 6.2.1.1,6.2.1.32 1.42e-253 814.0
HKD2_k127_315095_10 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 331.0
HKD2_k127_315095_11 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 307.0
HKD2_k127_315095_12 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000132 286.0
HKD2_k127_315095_14 - - - - 0.0000000000000000000000000000000000000000000000002318 181.0
HKD2_k127_315095_15 Toprim domain K06919 - - 0.0000000000000000000000000000000000002303 152.0
HKD2_k127_315095_16 AAA domain - - - 0.000000000000000001115 91.0
HKD2_k127_315095_2 Branched-chain amino acid transport system / permease component - - - 2.664e-240 758.0
HKD2_k127_315095_3 von Willebrand factor (vWF) type A domain - - - 7.318e-231 749.0
HKD2_k127_315095_4 Luciferase-like monooxygenase K14733 - 1.14.13.107 5.892e-211 675.0
HKD2_k127_315095_5 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 452.0
HKD2_k127_315095_6 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 428.0
HKD2_k127_315095_7 KR domain K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 415.0
HKD2_k127_315095_8 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 385.0
HKD2_k127_315095_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 374.0
HKD2_k127_317218_0 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 9.688e-278 859.0
HKD2_k127_317218_1 Glycosyl transferase family group 2 - - - 1.321e-239 745.0
HKD2_k127_317218_2 Glycosyl transferase, family 2 - - - 8.571e-223 695.0
HKD2_k127_317218_3 amidinotransferase K00613 - 2.1.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 542.0
HKD2_k127_317218_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 456.0
HKD2_k127_317218_5 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 393.0
HKD2_k127_317218_6 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000398 140.0
HKD2_k127_3213846_0 ABC transporter transmembrane region - - - 0.0 1930.0
HKD2_k127_3213846_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1210.0
HKD2_k127_3213846_10 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008072 483.0
HKD2_k127_3213846_11 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 488.0
HKD2_k127_3213846_12 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 480.0
HKD2_k127_3213846_13 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 456.0
HKD2_k127_3213846_14 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 456.0
HKD2_k127_3213846_15 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 478.0
HKD2_k127_3213846_16 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 435.0
HKD2_k127_3213846_17 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 425.0
HKD2_k127_3213846_18 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 399.0
HKD2_k127_3213846_19 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 407.0
HKD2_k127_3213846_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0 1028.0
HKD2_k127_3213846_20 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 373.0
HKD2_k127_3213846_21 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 380.0
HKD2_k127_3213846_22 PFAM beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 377.0
HKD2_k127_3213846_23 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 360.0
HKD2_k127_3213846_24 ABC transporter K02065,K02068 GO:0005575,GO:0005623,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0042592,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 317.0
HKD2_k127_3213846_25 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 319.0
HKD2_k127_3213846_26 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 297.0
HKD2_k127_3213846_3 TIGRFAM L-lactate transport K03303 - - 2.118e-276 859.0
HKD2_k127_3213846_30 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000002577 235.0
HKD2_k127_3213846_31 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000001393 224.0
HKD2_k127_3213846_32 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000001676 210.0
HKD2_k127_3213846_33 Transcriptional regulator, Crp Fnr family - - - 0.000000000000000000000000000000000000000000000000007928 188.0
HKD2_k127_3213846_34 - - - - 0.0000000000000000000000000000000000000000000001248 173.0
HKD2_k127_3213846_36 Transcriptional regulatory protein, C terminal K14981 - - 0.00000000000000000000000000000000002163 141.0
HKD2_k127_3213846_37 - - - - 0.000000000000000000000000000000000186 134.0
HKD2_k127_3213846_39 transposase activity - - - 0.000000000000000000000000000004088 129.0
HKD2_k127_3213846_4 Sugar (and other) transporter K05548,K08369 - - 2.462e-235 739.0
HKD2_k127_3213846_41 Transcriptional regulator - - - 0.0000000000000000000000003519 108.0
HKD2_k127_3213846_42 Transcriptional regulatory protein, C terminal K14981 - - 0.00000000000000001151 83.0
HKD2_k127_3213846_43 - - - - 0.0000000001288 66.0
HKD2_k127_3213846_44 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000001304 72.0
HKD2_k127_3213846_45 Protein of unknown function (DUF3175) - - - 0.0000000001514 64.0
HKD2_k127_3213846_47 Domain of unknown function (DUF4220) - - - 0.0003888 47.0
HKD2_k127_3213846_5 Major Facilitator Superfamily K08223 - - 8.136e-204 644.0
HKD2_k127_3213846_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.578e-199 635.0
HKD2_k127_3213846_7 Phosphotransferase enzyme family - - - 3.879e-195 638.0
HKD2_k127_3213846_8 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 558.0
HKD2_k127_3213846_9 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 485.0
HKD2_k127_3216883_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1307.0
HKD2_k127_3216883_1 Acyl-CoA dehydrogenase, middle domain - - - 4.775e-246 762.0
HKD2_k127_3216883_10 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 469.0
HKD2_k127_3216883_11 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 440.0
HKD2_k127_3216883_12 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 440.0
HKD2_k127_3216883_13 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 372.0
HKD2_k127_3216883_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 376.0
HKD2_k127_3216883_15 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 338.0
HKD2_k127_3216883_16 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000000000000000000000000000003458 233.0
HKD2_k127_3216883_17 NADPH-quinone reductase (modulator of drug activity B) - - - 0.000000000000000000000000000000000000000000000000000000000000001163 224.0
HKD2_k127_3216883_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000003784 230.0
HKD2_k127_3216883_19 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000002956 194.0
HKD2_k127_3216883_2 Cytochrome P450 - - - 1.642e-245 761.0
HKD2_k127_3216883_20 RNA signal recognition particle 4.5S RNA - - - 0.000000000000000000000000000000000000000000000000001076 185.0
HKD2_k127_3216883_22 Protein of unknown function (DUF2892) - - - 0.000000000000000000000000000000000000000000001229 166.0
HKD2_k127_3216883_23 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K11686,K13640,K18997 - - 0.000000000000000000000000000000000000000005635 163.0
HKD2_k127_3216883_24 - - - - 0.0000000000000000000000007696 112.0
HKD2_k127_3216883_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000001071 60.0
HKD2_k127_3216883_3 Beta-eliminating lyase K01620 - 4.1.2.48 2.497e-198 631.0
HKD2_k127_3216883_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 601.0
HKD2_k127_3216883_6 Molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 533.0
HKD2_k127_3216883_7 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 503.0
HKD2_k127_3216883_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 485.0
HKD2_k127_3216883_9 Protein of unknown function (DUF1194) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008983 485.0
HKD2_k127_3255511_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 1.507e-318 980.0
HKD2_k127_3255511_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 2.193e-261 809.0
HKD2_k127_3255511_10 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 385.0
HKD2_k127_3255511_11 TIGRFAM glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 372.0
HKD2_k127_3255511_12 Glutathione S-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008772 361.0
HKD2_k127_3255511_13 Phage plasmid primase P4 family K06919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 356.0
HKD2_k127_3255511_14 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 359.0
HKD2_k127_3255511_15 Bile acid K14347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 342.0
HKD2_k127_3255511_16 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 332.0
HKD2_k127_3255511_17 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 298.0
HKD2_k127_3255511_18 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002293 275.0
HKD2_k127_3255511_19 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005253 286.0
HKD2_k127_3255511_2 MatE - - - 3.186e-242 753.0
HKD2_k127_3255511_20 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004262 266.0
HKD2_k127_3255511_21 belongs to the UPF0276 family K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003304 254.0
HKD2_k127_3255511_22 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000003333 225.0
HKD2_k127_3255511_23 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000001711 235.0
HKD2_k127_3255511_24 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000002646 187.0
HKD2_k127_3255511_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000002372 182.0
HKD2_k127_3255511_26 GYD domain - - - 0.000000000000000000000000000000009087 129.0
HKD2_k127_3255511_27 - - - - 0.0000000000000000000000000009649 130.0
HKD2_k127_3255511_28 Polysaccharide biosynthesis protein - - - 0.000000000000000000000005404 117.0
HKD2_k127_3255511_29 VanZ like family - - - 0.000000000000000001402 91.0
HKD2_k127_3255511_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 1.317e-201 635.0
HKD2_k127_3255511_31 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000004479 66.0
HKD2_k127_3255511_32 Cupin domain - - - 0.00000005233 59.0
HKD2_k127_3255511_33 Mycolic acid cyclopropane synthetase - - - 0.0008117 51.0
HKD2_k127_3255511_4 homoserine dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 595.0
HKD2_k127_3255511_5 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 548.0
HKD2_k127_3255511_6 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 524.0
HKD2_k127_3255511_7 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 453.0
HKD2_k127_3255511_8 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 423.0
HKD2_k127_3255511_9 Tetrapyrrole (Corrin/Porphyrin) Methylases K02228 - 2.1.1.152 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 398.0
HKD2_k127_3267703_0 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 9.9e-304 940.0
HKD2_k127_3267703_1 Belongs to the ABC transporter superfamily K13896 - - 2.393e-296 926.0
HKD2_k127_3267703_2 transport system, permease component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 583.0
HKD2_k127_3267703_3 transport system, permease component K13895 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 576.0
HKD2_k127_3267703_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 335.0
HKD2_k127_3267703_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 315.0
HKD2_k127_3267703_6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000004667 289.0
HKD2_k127_3267703_7 - - - - 0.00000000000000000000000000000000000000000000000000000000001773 207.0
HKD2_k127_3269348_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.77e-286 892.0
HKD2_k127_3269348_1 Bacterial protein of unknown function (DUF853) K06915 - - 1.24e-254 801.0
HKD2_k127_3269348_10 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 393.0
HKD2_k127_3269348_11 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 385.0
HKD2_k127_3269348_12 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 364.0
HKD2_k127_3269348_13 myo-inosose-2 dehydratase activity K01805,K19974 - 5.1.3.35,5.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 346.0
HKD2_k127_3269348_14 AntiSigma factor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 308.0
HKD2_k127_3269348_15 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 299.0
HKD2_k127_3269348_16 COG3474 Cytochrome c2 K08738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 297.0
HKD2_k127_3269348_17 'TIGRFAM RNA polymerase sigma factor, sigma-70 family' K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004016 270.0
HKD2_k127_3269348_18 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002918 261.0
HKD2_k127_3269348_19 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000007489 241.0
HKD2_k127_3269348_2 COG1960 Acyl-CoA dehydrogenases - - - 7.368e-230 713.0
HKD2_k127_3269348_20 Heavy-metal resistance - - - 0.000000000000000000000000000000000000000000000000002503 194.0
HKD2_k127_3269348_21 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000000000000000000008745 182.0
HKD2_k127_3269348_22 Cupredoxin-like domain - - - 0.000000000000000000000000000000000000002479 150.0
HKD2_k127_3269348_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 2.375e-206 649.0
HKD2_k127_3269348_4 His Kinase A (phosphoacceptor) domain - - - 5.24e-200 633.0
HKD2_k127_3269348_5 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 518.0
HKD2_k127_3269348_6 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 494.0
HKD2_k127_3269348_7 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 451.0
HKD2_k127_3269348_8 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 424.0
HKD2_k127_3269348_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 385.0
HKD2_k127_3288564_0 ABC transporter transmembrane region K02021 - - 0.0 1554.0
HKD2_k127_3288564_1 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 0.0 1104.0
HKD2_k127_3288564_10 Gram-negative porin K08720 - - 7.466e-197 624.0
HKD2_k127_3288564_11 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 561.0
HKD2_k127_3288564_12 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 547.0
HKD2_k127_3288564_13 COG0708 Exonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 509.0
HKD2_k127_3288564_14 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 501.0
HKD2_k127_3288564_15 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 490.0
HKD2_k127_3288564_16 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 469.0
HKD2_k127_3288564_17 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 462.0
HKD2_k127_3288564_18 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 462.0
HKD2_k127_3288564_19 Bacterial periplasmic substrate-binding proteins K10018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 466.0
HKD2_k127_3288564_2 LUD domain K18929 - - 4.684e-281 876.0
HKD2_k127_3288564_20 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 452.0
HKD2_k127_3288564_21 (Fe-S) oxidoreductase K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 448.0
HKD2_k127_3288564_22 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 411.0
HKD2_k127_3288564_23 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 407.0
HKD2_k127_3288564_24 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 397.0
HKD2_k127_3288564_25 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 382.0
HKD2_k127_3288564_26 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 373.0
HKD2_k127_3288564_27 COG1138 Cytochrome c biogenesis factor K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 368.0
HKD2_k127_3288564_28 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 355.0
HKD2_k127_3288564_29 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 359.0
HKD2_k127_3288564_3 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 1.711e-247 771.0
HKD2_k127_3288564_30 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 350.0
HKD2_k127_3288564_31 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 347.0
HKD2_k127_3288564_32 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 290.0
HKD2_k127_3288564_33 S-adenosyl-L-methionine methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 280.0
HKD2_k127_3288564_34 Domain of unknown function (DUF3576) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006695 276.0
HKD2_k127_3288564_35 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003931 263.0
HKD2_k127_3288564_36 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002196 262.0
HKD2_k127_3288564_37 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005195 245.0
HKD2_k127_3288564_38 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000000000000000000000003607 243.0
HKD2_k127_3288564_39 Hemimethylated DNA-binding protein YccV like K11940 - - 0.000000000000000000000000000000000000000000000000000000000000496 217.0
HKD2_k127_3288564_4 Glycosyltransferase family 28 C-terminal domain - - - 2.504e-235 734.0
HKD2_k127_3288564_40 Transglycosylase associated protein - - - 0.0000000000000000000000000000001298 124.0
HKD2_k127_3288564_5 N-terminal TM domain of oligopeptide transport permease C K02034 - - 1.402e-233 726.0
HKD2_k127_3288564_6 Involved in the biosynthesis of porphyrin-containing compound - - - 1.717e-209 656.0
HKD2_k127_3288564_7 Glycosyl transferases group 1 - - - 1.55e-207 660.0
HKD2_k127_3288564_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 1.369e-202 639.0
HKD2_k127_3288564_9 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 9.753e-200 636.0
HKD2_k127_336881_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 473.0
HKD2_k127_336881_1 Asparaginase K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 447.0
HKD2_k127_336881_2 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 433.0
HKD2_k127_336881_3 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 389.0
HKD2_k127_336881_4 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 326.0
HKD2_k127_336881_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000007401 222.0
HKD2_k127_336881_6 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000000000000004505 211.0
HKD2_k127_3463699_0 AFG1-like ATPase K06916 - - 1.819e-206 646.0
HKD2_k127_3463699_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 531.0
HKD2_k127_3463699_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 504.0
HKD2_k127_3463699_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 460.0
HKD2_k127_3463699_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 420.0
HKD2_k127_3463699_5 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 347.0
HKD2_k127_3463699_6 - - - - 0.000000000000000000000003018 102.0
HKD2_k127_362461_0 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 8.84e-258 823.0
HKD2_k127_362461_1 Paraquat-inducible protein B K06192 - - 1.209e-253 793.0
HKD2_k127_362461_10 WD40 repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 581.0
HKD2_k127_362461_11 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 426.0
HKD2_k127_362461_12 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 388.0
HKD2_k127_362461_13 COG0524 Sugar kinases, ribokinase family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 372.0
HKD2_k127_362461_14 Uncharacterized protein conserved in bacteria (DUF2334) K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 337.0
HKD2_k127_362461_15 Protein conserved in bacteria K09857 - - 0.000000000000000000000000000000000000000000000000000000000000000005881 245.0
HKD2_k127_362461_16 DsrE/DsrF-like family - - - 0.000000000000000000000000000000000000000000000000000000000000007869 225.0
HKD2_k127_362461_17 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000000000000000000002904 215.0
HKD2_k127_362461_18 Belongs to the P(II) protein family K04752 - - 0.00000000000000000000000000000000000000000000000000000006855 200.0
HKD2_k127_362461_19 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.00000000000000000000000000000000000000000002391 161.0
HKD2_k127_362461_2 Ammonium transporter K03320 - - 5.669e-250 778.0
HKD2_k127_362461_3 COG0004 Ammonia permease K03320 - - 2.166e-245 766.0
HKD2_k127_362461_4 Acetyl-coenzyme A transporter 1 K08218 - - 3.313e-225 712.0
HKD2_k127_362461_5 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K03185 - - 5.235e-223 698.0
HKD2_k127_362461_6 COG0436 Aspartate tyrosine aromatic aminotransferase K14267 - 2.6.1.17 9e-213 666.0
HKD2_k127_362461_7 Major facilitator superfamily K07552 - - 6.268e-203 637.0
HKD2_k127_362461_8 paraquat-inducible protein A K03808 - - 2.012e-202 640.0
HKD2_k127_362461_9 cobalamin synthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 603.0
HKD2_k127_3716637_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1363.0
HKD2_k127_3716637_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1207.0
HKD2_k127_3716637_10 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 496.0
HKD2_k127_3716637_11 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 461.0
HKD2_k127_3716637_12 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009205 446.0
HKD2_k127_3716637_13 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 438.0
HKD2_k127_3716637_14 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 420.0
HKD2_k127_3716637_15 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 395.0
HKD2_k127_3716637_16 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 400.0
HKD2_k127_3716637_17 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 391.0
HKD2_k127_3716637_18 GHMP kinases N terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 366.0
HKD2_k127_3716637_19 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 356.0
HKD2_k127_3716637_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 2.147e-319 981.0
HKD2_k127_3716637_21 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 347.0
HKD2_k127_3716637_22 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 298.0
HKD2_k127_3716637_23 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 293.0
HKD2_k127_3716637_24 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001184 293.0
HKD2_k127_3716637_25 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001291 282.0
HKD2_k127_3716637_26 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000005395 277.0
HKD2_k127_3716637_27 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) K01809 - 5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000002688 274.0
HKD2_k127_3716637_28 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003364 260.0
HKD2_k127_3716637_29 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000001388 254.0
HKD2_k127_3716637_3 ABC-type multidrug transport system, ATPase and permease K06147 - - 5.15e-307 953.0
HKD2_k127_3716637_30 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000001018 250.0
HKD2_k127_3716637_31 Dehydrogenase E1 component K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000001893 214.0
HKD2_k127_3716637_32 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000002079 203.0
HKD2_k127_3716637_33 C-methyltransferase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000135 181.0
HKD2_k127_3716637_34 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000000000000000000128 171.0
HKD2_k127_3716637_35 Belongs to the frataxin family K19054 - 1.16.3.1 0.0000000000000000000000000000000000000000225 156.0
HKD2_k127_3716637_36 transposase activity - - - 0.00000000000000000000000000000002038 141.0
HKD2_k127_3716637_38 Methyltransferase FkbM domain - - - 0.00000000000000003116 91.0
HKD2_k127_3716637_4 Major Facilitator Superfamily - - - 5.65e-226 705.0
HKD2_k127_3716637_5 Chaperone SurA K03771 - 5.2.1.8 1.478e-195 618.0
HKD2_k127_3716637_6 radical SAM domain protein K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 556.0
HKD2_k127_3716637_7 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 553.0
HKD2_k127_3716637_8 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 546.0
HKD2_k127_3716637_9 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 490.0
HKD2_k127_376059_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.476e-288 894.0
HKD2_k127_376059_1 (E1) component, eukaryotic type, alpha subunit K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 330.0
HKD2_k127_376059_2 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 319.0
HKD2_k127_376059_3 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003108 276.0
HKD2_k127_376059_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001202 262.0
HKD2_k127_376059_5 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000001482 102.0
HKD2_k127_376059_6 Receptor family ligand binding region - - - 0.00000000000000000000005336 100.0
HKD2_k127_376059_7 - - - - 0.0006689 46.0
HKD2_k127_3772231_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - 0.0 1246.0
HKD2_k127_3772231_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0 1229.0
HKD2_k127_3772231_10 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 524.0
HKD2_k127_3772231_11 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009305 455.0
HKD2_k127_3772231_12 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 433.0
HKD2_k127_3772231_13 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 429.0
HKD2_k127_3772231_14 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00467,K16422 - 1.1.2.3,1.1.3.46,1.13.12.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 419.0
HKD2_k127_3772231_15 transcriptional regulator, AraC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 411.0
HKD2_k127_3772231_16 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 392.0
HKD2_k127_3772231_17 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 393.0
HKD2_k127_3772231_18 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009092 373.0
HKD2_k127_3772231_19 Belongs to the D-glutamate cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 329.0
HKD2_k127_3772231_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 1.55e-314 1000.0
HKD2_k127_3772231_20 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 291.0
HKD2_k127_3772231_21 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003313 279.0
HKD2_k127_3772231_22 PFAM periplasmic solute binding protein K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002781 272.0
HKD2_k127_3772231_23 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003103 261.0
HKD2_k127_3772231_24 ABC-type Mn2 Zn2 transport systems, permease components K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001177 266.0
HKD2_k127_3772231_25 Uncharacterized protein conserved in bacteria (DUF2076) K09945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001117 250.0
HKD2_k127_3772231_26 Protein conserved in bacteria K09983 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001429 248.0
HKD2_k127_3772231_27 ATPases associated with a variety of cellular activities K02074 - - 0.000000000000000000000000000000000000000000000000000000000000000000002872 246.0
HKD2_k127_3772231_28 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001398 239.0
HKD2_k127_3772231_29 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000002938 196.0
HKD2_k127_3772231_3 TonB dependent receptor - - - 1.378e-280 882.0
HKD2_k127_3772231_30 Protein of unknown function (DUF3574) - - - 0.00000000000000000000000000000000000000000000005556 177.0
HKD2_k127_3772231_31 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000009934 169.0
HKD2_k127_3772231_32 Hsp20/alpha crystallin family - - - 0.0000000000000000000000000000000000000001378 154.0
HKD2_k127_3772231_33 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000004345 141.0
HKD2_k127_3772231_34 IclR helix-turn-helix domain K10439 - - 0.0000000000000000000000002649 119.0
HKD2_k127_3772231_35 YCII-related domain K09780 - - 0.00000000000002181 77.0
HKD2_k127_3772231_36 - - - - 0.000003459 59.0
HKD2_k127_3772231_37 Recombinase zinc beta ribbon domain K06400 - - 0.0007259 45.0
HKD2_k127_3772231_4 Beta-lactamase - - - 5.166e-229 725.0
HKD2_k127_3772231_5 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 3.95e-226 706.0
HKD2_k127_3772231_6 Phosphoesterase family K01114 - 3.1.4.3 2.892e-194 620.0
HKD2_k127_3772231_7 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 590.0
HKD2_k127_3772231_8 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 529.0
HKD2_k127_3772231_9 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 533.0
HKD2_k127_3879360_0 E1-E2 ATPase K17686 - 3.6.3.54 0.0 1045.0
HKD2_k127_3879360_1 Thymidine phosphorylase K00758 - 2.4.2.4 2.942e-198 631.0
HKD2_k127_3879360_2 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 603.0
HKD2_k127_3879360_3 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 492.0
HKD2_k127_3879360_4 COG1136 ABC-type antimicrobial peptide transport system ATPase component K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 373.0
HKD2_k127_3879360_5 N-terminal domain of ribose phosphate pyrophosphokinase K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 331.0
HKD2_k127_3879360_6 Ribosomal protein L11 methyltransferase (PrmA) K05929 - 2.1.1.103 0.00000000000000000000000000000000000000002253 177.0
HKD2_k127_3883060_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 1.085e-225 717.0
HKD2_k127_3883060_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 597.0
HKD2_k127_3883060_10 Shikimate kinase - - - 0.00000000000000000000000000000000000000000003224 168.0
HKD2_k127_3883060_11 belongs to the bacterial solute-binding protein 3 family K02030 - - 0.00000001476 57.0
HKD2_k127_3883060_2 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 547.0
HKD2_k127_3883060_3 TOBE domain K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 497.0
HKD2_k127_3883060_4 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 481.0
HKD2_k127_3883060_5 Belongs to the DapA family K01714,K21062 - 3.5.4.22,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 443.0
HKD2_k127_3883060_6 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 394.0
HKD2_k127_3883060_7 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004991 385.0
HKD2_k127_3883060_8 Asp/Glu/Hydantoin racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 304.0
HKD2_k127_3883060_9 Proline racemase K12658 - 5.1.1.8 0.0000000000000000000000000000000000000000000001924 177.0
HKD2_k127_3888993_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1146.0
HKD2_k127_3888993_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.007e-296 915.0
HKD2_k127_3888993_10 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000000000000000000000000001256 150.0
HKD2_k127_3888993_12 CsbD-like - - - 0.000000000000000000000000000001669 122.0
HKD2_k127_3888993_13 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000001357 119.0
HKD2_k127_3888993_14 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000000000000000001618 120.0
HKD2_k127_3888993_15 Protein of unknown function (DUF1328) - - - 0.000000000000000001032 91.0
HKD2_k127_3888993_2 Histidine kinase - - - 3.311e-211 684.0
HKD2_k127_3888993_3 DinB superfamily - - - 6.895e-194 611.0
HKD2_k127_3888993_4 ubiquitin protein ligase binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 402.0
HKD2_k127_3888993_5 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 362.0
HKD2_k127_3888993_6 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 329.0
HKD2_k127_3888993_7 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 297.0
HKD2_k127_3888993_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000001815 230.0
HKD2_k127_3993603_0 Chromate transporter K07240 - - 1.378e-212 669.0
HKD2_k127_3993603_1 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 511.0
HKD2_k127_3993603_10 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244,K19743 - 1.4.1.1,1.5.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 299.0
HKD2_k127_3993603_11 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 285.0
HKD2_k127_3993603_12 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 291.0
HKD2_k127_3993603_13 Pyruvate phosphate dikinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009593 289.0
HKD2_k127_3993603_14 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000009442 227.0
HKD2_k127_3993603_16 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000002461 130.0
HKD2_k127_3993603_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009333 467.0
HKD2_k127_3993603_3 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 454.0
HKD2_k127_3993603_4 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 402.0
HKD2_k127_3993603_5 PHB de-polymerase C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 355.0
HKD2_k127_3993603_6 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 347.0
HKD2_k127_3993603_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 309.0
HKD2_k127_3993603_8 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 314.0
HKD2_k127_3993603_9 PFAM multi antimicrobial extrusion protein MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 317.0
HKD2_k127_399772_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.821e-274 865.0
HKD2_k127_399772_1 transmembrane transport - - - 1.664e-206 649.0
HKD2_k127_399772_10 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031,K15583 - - 0.0000000000000000000000000000000000000000000153 169.0
HKD2_k127_399772_11 Beta-lactamase - - - 0.000000000000000000000000000000000000000002087 161.0
HKD2_k127_399772_12 Beta-lactamase - - - 0.0000000000000000000000000000000006291 142.0
HKD2_k127_399772_13 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000001536 109.0
HKD2_k127_399772_14 Bacterial EndoU nuclease - - - 0.000000000000000156 88.0
HKD2_k127_399772_15 Bacterial EndoU nuclease - - - 0.00000000000001712 82.0
HKD2_k127_399772_16 Beta-lactamase - - - 0.000000000001547 74.0
HKD2_k127_399772_17 - - - - 0.00000000001896 66.0
HKD2_k127_399772_18 Unextendable partial coding region - - - 0.00000000002734 65.0
HKD2_k127_399772_19 Bacterial EndoU nuclease - - - 0.0000001207 61.0
HKD2_k127_399772_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003628 526.0
HKD2_k127_399772_3 Domain of unknown function (DUF1989) K09967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 459.0
HKD2_k127_399772_4 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 417.0
HKD2_k127_399772_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 326.0
HKD2_k127_399772_6 Domain of unknown function (DUF1989) K09967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006079 274.0
HKD2_k127_399772_7 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005047 269.0
HKD2_k127_399772_8 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000004091 220.0
HKD2_k127_399772_9 - K20268 - - 0.00000000000000000000000000000000000000000000000005268 187.0
HKD2_k127_4038646_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 3e-323 1001.0
HKD2_k127_4038646_1 Peptidase family M20/M25/M40 - - - 2.049e-300 925.0
HKD2_k127_4038646_10 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002326 266.0
HKD2_k127_4038646_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000004946 169.0
HKD2_k127_4038646_12 GYD domain - - - 0.0000000000000000000000000000000000000000008471 162.0
HKD2_k127_4038646_13 tRNA modification K06968 - 2.1.1.186 0.000000000000000000000000000000000005008 146.0
HKD2_k127_4038646_14 Protein of unknown function (DUF3987) - - - 0.0000000000000000000000000000000001048 150.0
HKD2_k127_4038646_15 ChrR Cupin-like domain K07167 - - 0.00000000000000000000000000000001985 136.0
HKD2_k127_4038646_16 Adenylate cyclase - - - 0.000000000000000000000000000001977 128.0
HKD2_k127_4038646_17 Protein of unknown function (DUF559) - - - 0.0000000000000000000000000003091 117.0
HKD2_k127_4038646_18 Mu-like prophage FluMu protein gp28 - - - 0.000000000000000000002431 100.0
HKD2_k127_4038646_19 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.0000000000006278 80.0
HKD2_k127_4038646_2 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 2.225e-276 859.0
HKD2_k127_4038646_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 2.667e-210 662.0
HKD2_k127_4038646_4 Iron-containing alcohol dehydrogenase - - - 6.972e-206 648.0
HKD2_k127_4038646_5 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 479.0
HKD2_k127_4038646_6 Ca2 -binding protein (EF-Hand superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009 460.0
HKD2_k127_4038646_7 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 334.0
HKD2_k127_4038646_8 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 333.0
HKD2_k127_4038646_9 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 315.0
HKD2_k127_4053606_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1872.0
HKD2_k127_4053606_1 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 1.444e-227 707.0
HKD2_k127_4053606_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 313.0
HKD2_k127_4053606_11 Protein conserved in bacteria K09962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000453 282.0
HKD2_k127_4053606_12 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000003383 233.0
HKD2_k127_4053606_13 YqcI/YcgG family - - - 0.0000000000000000000000000000000000000000000000000000000001567 211.0
HKD2_k127_4053606_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000004105 147.0
HKD2_k127_4053606_16 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000002256 115.0
HKD2_k127_4053606_17 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000005375 107.0
HKD2_k127_4053606_18 Transcriptional regulator K18297 - - 0.0000000000000000000001745 105.0
HKD2_k127_4053606_19 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000003569 68.0
HKD2_k127_4053606_2 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 8.603e-216 672.0
HKD2_k127_4053606_20 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000004986 51.0
HKD2_k127_4053606_3 Elongator protein 3, MiaB family, Radical SAM - - - 7.108e-202 634.0
HKD2_k127_4053606_4 COG1194 A G-specific DNA glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 595.0
HKD2_k127_4053606_5 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005196 467.0
HKD2_k127_4053606_6 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 359.0
HKD2_k127_4053606_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 343.0
HKD2_k127_4053606_8 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 340.0
HKD2_k127_4053606_9 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 315.0
HKD2_k127_4099447_0 Amidase K01426 - 3.5.1.4 4.194e-255 816.0
HKD2_k127_4099447_1 Alcohol dehydrogenase GroES-like domain - - - 3.689e-225 713.0
HKD2_k127_4099447_10 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 436.0
HKD2_k127_4099447_11 Nitroreductase K10678 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 430.0
HKD2_k127_4099447_12 Methyladenine glycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 397.0
HKD2_k127_4099447_13 PFAM Asp Glu hydantoin racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 368.0
HKD2_k127_4099447_14 Acetyltransferase (GNAT) domain K03829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007553 256.0
HKD2_k127_4099447_15 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003851 263.0
HKD2_k127_4099447_16 Short-chain dehydrogenase reductase (SDR) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001033 241.0
HKD2_k127_4099447_17 Ion channel - - - 0.0000000000000000000000000000000000002507 146.0
HKD2_k127_4099447_18 LTXXQ motif family protein - - - 0.0000000000000000113 90.0
HKD2_k127_4099447_19 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000002747 59.0
HKD2_k127_4099447_2 Transglutaminase/protease-like homologues - - - 5.32e-216 681.0
HKD2_k127_4099447_20 Amidohydrolase K07045 - - 0.0005362 51.0
HKD2_k127_4099447_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 2.404e-202 634.0
HKD2_k127_4099447_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007173 601.0
HKD2_k127_4099447_5 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 596.0
HKD2_k127_4099447_6 monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 557.0
HKD2_k127_4099447_7 monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 506.0
HKD2_k127_4099447_8 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 442.0
HKD2_k127_4099447_9 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 440.0
HKD2_k127_415600_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 2455.0
HKD2_k127_415600_1 Major Facilitator Superfamily K02575 - - 0.0 1633.0
HKD2_k127_415600_2 Nitrate reductase beta subunit K00371 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 575.0
HKD2_k127_415600_3 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 475.0
HKD2_k127_415600_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K13642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 351.0
HKD2_k127_415600_5 B-1 B cell differentiation K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001651 277.0
HKD2_k127_415600_6 Papain family cysteine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002781 264.0
HKD2_k127_415600_7 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000008315 214.0
HKD2_k127_415600_8 Belongs to the ompA family - - - 0.00000000000000000000000000000118 130.0
HKD2_k127_4167889_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0 1053.0
HKD2_k127_4167889_1 Belongs to the UbiD family K03182 - 4.1.1.98 0.0 1002.0
HKD2_k127_4167889_10 Metallo-beta-lactamase superfamily - - - 1.215e-225 701.0
HKD2_k127_4167889_11 Lytic murein transglycosylase K08305 - - 5.422e-217 678.0
HKD2_k127_4167889_12 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 1.54e-211 666.0
HKD2_k127_4167889_13 Protein of unknown function (DUF3419) - - - 9.319e-207 649.0
HKD2_k127_4167889_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 9.338e-195 621.0
HKD2_k127_4167889_15 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 606.0
HKD2_k127_4167889_16 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 579.0
HKD2_k127_4167889_17 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 543.0
HKD2_k127_4167889_18 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 536.0
HKD2_k127_4167889_19 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 530.0
HKD2_k127_4167889_2 glutamate--cysteine ligase K01919 - 6.3.2.2 3.95e-279 862.0
HKD2_k127_4167889_20 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 507.0
HKD2_k127_4167889_21 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 502.0
HKD2_k127_4167889_22 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 502.0
HKD2_k127_4167889_23 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 451.0
HKD2_k127_4167889_24 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 447.0
HKD2_k127_4167889_25 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 437.0
HKD2_k127_4167889_26 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 431.0
HKD2_k127_4167889_27 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 419.0
HKD2_k127_4167889_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 406.0
HKD2_k127_4167889_29 Amidohydrolase K07046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 393.0
HKD2_k127_4167889_3 Malonyl-CoA decarboxylase N-terminal domain K01578 - 4.1.1.9 3.748e-265 820.0
HKD2_k127_4167889_30 WHG domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 383.0
HKD2_k127_4167889_31 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 378.0
HKD2_k127_4167889_32 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 389.0
HKD2_k127_4167889_33 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 371.0
HKD2_k127_4167889_34 Methyltransferase K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 292.0
HKD2_k127_4167889_35 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001523 289.0
HKD2_k127_4167889_36 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002131 292.0
HKD2_k127_4167889_37 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004648 277.0
HKD2_k127_4167889_38 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003989 254.0
HKD2_k127_4167889_39 flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group K06205 GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000001784 258.0
HKD2_k127_4167889_4 Zn-dependent proteases and their inactivated homologs K03592 - - 9.541e-248 771.0
HKD2_k127_4167889_40 CreA protein K05805 - - 0.00000000000000000000000000000000000000000000000000000000000000000001974 235.0
HKD2_k127_4167889_41 Protein of unknown function (DUF2852) - - - 0.000000000000000000000000000000000000000000000000000000000000007163 218.0
HKD2_k127_4167889_42 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000007555 209.0
HKD2_k127_4167889_43 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000009583 196.0
HKD2_k127_4167889_44 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000001032 158.0
HKD2_k127_4167889_45 Passenger-associated-transport-repeat - - - 0.000000000000000000000000000000000000007432 159.0
HKD2_k127_4167889_46 PIN domain - - - 0.0000000000000000000000000009599 117.0
HKD2_k127_4167889_48 - - - - 0.00000000000000000004347 92.0
HKD2_k127_4167889_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 1.767e-246 768.0
HKD2_k127_4167889_50 positive regulation of growth - - - 0.00000000004445 66.0
HKD2_k127_4167889_6 ABC-type multidrug transport system ATPase and permease K06147 - - 1.347e-240 758.0
HKD2_k127_4167889_7 L-carnitine dehydratase bile acid-inducible protein - - - 7.114e-239 741.0
HKD2_k127_4167889_8 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 2.061e-236 734.0
HKD2_k127_4167889_9 Belongs to the GARS family K01945 - 6.3.4.13 1.09e-228 713.0
HKD2_k127_4192582_0 TonB dependent receptor - - - 1.06e-310 967.0
HKD2_k127_4192582_1 Epoxide hydrolase N terminus K01253 - 3.3.2.9 1.17e-245 766.0
HKD2_k127_4192582_10 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 403.0
HKD2_k127_4192582_11 Protein of unknown function (DUF2889) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 388.0
HKD2_k127_4192582_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000016 308.0
HKD2_k127_4192582_13 Peptidase dimerisation domain K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001767 266.0
HKD2_k127_4192582_14 YjbR - - - 0.00000000000000000000000000005077 128.0
HKD2_k127_4192582_15 Protein of unknown function (DUF4239) - - - 0.0000000000000000000000000004815 123.0
HKD2_k127_4192582_16 GIY-YIG catalytic domain - - - 0.00000000000000004044 88.0
HKD2_k127_4192582_2 Mg2 and Co2 transporter CorB - - - 7.908e-229 716.0
HKD2_k127_4192582_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 1.864e-198 633.0
HKD2_k127_4192582_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 558.0
HKD2_k127_4192582_6 PFAM Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 527.0
HKD2_k127_4192582_7 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 499.0
HKD2_k127_4192582_8 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 475.0
HKD2_k127_4192582_9 Tyrosine phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 452.0
HKD2_k127_4207588_0 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0 1295.0
HKD2_k127_4207588_1 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 281.0
HKD2_k127_4207588_2 Protein of unknown function (DUF1761) - - - 0.000000000000000000000000000000000000000001103 160.0
HKD2_k127_4207588_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000002596 81.0
HKD2_k127_422335_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.505e-304 942.0
HKD2_k127_422335_1 GTP cyclohydrolase II activity - - - 1.192e-260 805.0
HKD2_k127_422335_10 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000004114 224.0
HKD2_k127_422335_11 PRC-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000004356 220.0
HKD2_k127_422335_12 protein conserved in bacteria K09796 - - 0.00000000000000000000000000000000000000000000000000000000000006216 221.0
HKD2_k127_422335_13 Small multidrug resistance protein K11741 - - 0.0000000000000000000000000000000000000000000000000001381 192.0
HKD2_k127_422335_14 MAPEG family - - - 0.0000000000000000000000000000000000000000000000000002101 191.0
HKD2_k127_422335_17 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000002911 128.0
HKD2_k127_422335_18 - - - - 0.00003161 49.0
HKD2_k127_422335_19 - - - - 0.00003435 52.0
HKD2_k127_422335_2 Luciferase-like monooxygenase - - - 4.791e-213 663.0
HKD2_k127_422335_3 Protein of unknown function (DUF1688) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 610.0
HKD2_k127_422335_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 587.0
HKD2_k127_422335_5 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 544.0
HKD2_k127_422335_6 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 460.0
HKD2_k127_422335_7 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 412.0
HKD2_k127_422335_8 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 404.0
HKD2_k127_422335_9 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 391.0
HKD2_k127_4258228_0 Virulence factor SrfB - - - 8.041e-256 790.0
HKD2_k127_4258228_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 1.688e-235 750.0
HKD2_k127_4258228_2 Virulence effector protein - - - 1.32e-222 699.0
HKD2_k127_4258228_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 2.641e-201 644.0
HKD2_k127_4258228_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 386.0
HKD2_k127_4258228_8 Hemin uptake protein - - - 0.000000001078 61.0
HKD2_k127_4266025_0 Histidine kinase-like ATPases - - - 0.0 1090.0
HKD2_k127_4266025_1 Phosphate transport regulator - - - 2.509e-244 771.0
HKD2_k127_4266025_2 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 1.021e-213 705.0
HKD2_k127_4266025_3 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 450.0
HKD2_k127_4266025_4 transport system periplasmic component K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 322.0
HKD2_k127_4266025_5 Cupin superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001714 297.0
HKD2_k127_4266025_6 cheY-homologous receiver domain K11443 - - 0.0000000000000000000000000000000000000000000000003641 190.0
HKD2_k127_4266025_7 ABC transporter substrate binding protein K01989 - - 0.0000000000006812 72.0
HKD2_k127_4266025_8 FR47-like protein - - - 0.00000002945 57.0
HKD2_k127_4266025_9 - - - - 0.0007093 49.0
HKD2_k127_4271028_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1976.0
HKD2_k127_4271028_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1479.0
HKD2_k127_4271028_10 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 321.0
HKD2_k127_4271028_11 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 298.0
HKD2_k127_4271028_12 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001135 282.0
HKD2_k127_4271028_13 leucine binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002595 278.0
HKD2_k127_4271028_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001666 242.0
HKD2_k127_4271028_15 - - - - 0.0000000000000000000000000000000000000000000005955 184.0
HKD2_k127_4271028_17 Cupin domain - - - 0.0000000000000000000000000000000000000157 154.0
HKD2_k127_4271028_2 COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit K13796 - - 1.713e-318 976.0
HKD2_k127_4271028_3 L-carnitine dehydratase bile acid-inducible protein F - - - 1.271e-232 723.0
HKD2_k127_4271028_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 1.895e-212 663.0
HKD2_k127_4271028_5 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 497.0
HKD2_k127_4271028_6 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 498.0
HKD2_k127_4271028_8 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 346.0
HKD2_k127_4271028_9 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 320.0
HKD2_k127_4278030_0 Circularly permuted ATP-grasp type 2 - - - 0.0 1352.0
HKD2_k127_4278030_1 Putative amidoligase enzyme (DUF2126) - - - 4.82e-289 900.0
HKD2_k127_4278030_2 Sugar (and other) transporter - - - 2.358e-257 800.0
HKD2_k127_4278030_3 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 434.0
HKD2_k127_4278030_4 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001644 287.0
HKD2_k127_4278030_5 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000008615 86.0
HKD2_k127_4280425_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1658.0
HKD2_k127_4280425_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1563.0
HKD2_k127_4280425_10 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 475.0
HKD2_k127_4280425_11 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 461.0
HKD2_k127_4280425_12 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 430.0
HKD2_k127_4280425_13 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009224 385.0
HKD2_k127_4280425_14 sequence-specific DNA binding K15539 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 371.0
HKD2_k127_4280425_16 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 289.0
HKD2_k127_4280425_17 Domain of unknown function (DUF4167) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 288.0
HKD2_k127_4280425_18 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002427 275.0
HKD2_k127_4280425_19 Protein of unknown function (DUF1178) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008099 269.0
HKD2_k127_4280425_2 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1353.0
HKD2_k127_4280425_20 SAM-dependent methyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003728 258.0
HKD2_k127_4280425_21 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000000000000143 243.0
HKD2_k127_4280425_22 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000000000000000000000001104 163.0
HKD2_k127_4280425_23 Protein of unknown function (DUF4239) - - - 0.0000000000000000000000000000000000000001167 160.0
HKD2_k127_4280425_3 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 9.512e-243 756.0
HKD2_k127_4280425_4 Belongs to the aspartokinase family K00928 - 2.7.2.4 7.045e-226 707.0
HKD2_k127_4280425_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.159e-225 704.0
HKD2_k127_4280425_6 COG0739 Membrane proteins related to metalloendopeptidases - - - 2.134e-223 702.0
HKD2_k127_4280425_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 4.192e-195 612.0
HKD2_k127_4280425_8 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 552.0
HKD2_k127_4280425_9 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 540.0
HKD2_k127_428197_0 ABC transporter K06147,K11004 - - 0.0 1126.0
HKD2_k127_428197_1 elongator protein 3 miab nifb - - - 0.0 1117.0
HKD2_k127_428197_10 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 550.0
HKD2_k127_428197_11 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 561.0
HKD2_k127_428197_12 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 497.0
HKD2_k127_428197_13 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 440.0
HKD2_k127_428197_14 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000914 412.0
HKD2_k127_428197_15 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 374.0
HKD2_k127_428197_16 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 389.0
HKD2_k127_428197_17 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 355.0
HKD2_k127_428197_18 Belongs to the bacterioferritin family K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 289.0
HKD2_k127_428197_19 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 287.0
HKD2_k127_428197_2 AMP-binding enzyme C-terminal domain - - - 4.141e-279 859.0
HKD2_k127_428197_20 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001448 255.0
HKD2_k127_428197_21 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001884 240.0
HKD2_k127_428197_22 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002996 233.0
HKD2_k127_428197_23 InterPro IPR014922 - - - 0.0000000000000000000000000000000000000000000000000000002947 196.0
HKD2_k127_428197_24 Protein of unknown function (DUF3309) - - - 0.0000000000000000000001397 97.0
HKD2_k127_428197_25 Glyoxalase-like domain - - - 0.00000000000000002466 84.0
HKD2_k127_428197_26 peptidase S8 and S53, subtilisin, kexin, sedolisin K17734 - - 0.00000000000168 82.0
HKD2_k127_428197_27 2Fe-2S -binding domain K02192 - - 0.0000000009784 68.0
HKD2_k127_428197_3 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 2.57e-227 706.0
HKD2_k127_428197_4 Transmembrane secretion effector - - - 9.819e-220 690.0
HKD2_k127_428197_5 TIGRFAM type I secretion membrane fusion protein, HlyD family K11003 - - 1.24e-208 658.0
HKD2_k127_428197_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 3.573e-204 649.0
HKD2_k127_428197_7 ammonia monooxygenase K07120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 585.0
HKD2_k127_428197_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 568.0
HKD2_k127_428197_9 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008847 558.0
HKD2_k127_4301874_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1369.0
HKD2_k127_4301874_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00612 - - 0.0 1138.0
HKD2_k127_4301874_10 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009193 447.0
HKD2_k127_4301874_11 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 437.0
HKD2_k127_4301874_12 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 433.0
HKD2_k127_4301874_13 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 437.0
HKD2_k127_4301874_14 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 419.0
HKD2_k127_4301874_15 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009896 404.0
HKD2_k127_4301874_16 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 407.0
HKD2_k127_4301874_17 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 360.0
HKD2_k127_4301874_18 2-hydroxychromene-2-carboxylate isomerase K14584 - 5.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 355.0
HKD2_k127_4301874_19 Belongs to the glycosyl hydrolase 18 family K01179,K01183 - 3.2.1.14,3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 369.0
HKD2_k127_4301874_2 Poly(3-hydroxyalkanoate) synthetase - - - 0.0 1049.0
HKD2_k127_4301874_20 Universal stress protein UspA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 336.0
HKD2_k127_4301874_21 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 332.0
HKD2_k127_4301874_22 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 307.0
HKD2_k127_4301874_23 hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 293.0
HKD2_k127_4301874_24 Putative MetA-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 293.0
HKD2_k127_4301874_25 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 292.0
HKD2_k127_4301874_26 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006503 263.0
HKD2_k127_4301874_27 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005724 243.0
HKD2_k127_4301874_28 Modulates RecA activity K03565 - - 0.00000000000000000000000000000000000000000000000000000000000000001233 245.0
HKD2_k127_4301874_29 [2Fe-2S] binding domain K18029 - 1.17.2.1 0.00000000000000000000000000000000000000000000000000000000000000003531 226.0
HKD2_k127_4301874_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 8.378e-295 911.0
HKD2_k127_4301874_30 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000005445 251.0
HKD2_k127_4301874_31 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000001568 224.0
HKD2_k127_4301874_32 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781 - 5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000001938 234.0
HKD2_k127_4301874_33 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000002088 226.0
HKD2_k127_4301874_34 Glycosyl hydrolases family 18 - - - 0.00000000000000000000000000000000000000000000000000000000001142 235.0
HKD2_k127_4301874_35 VIT family - - - 0.000000000000000000000000000000000000000000000000000522 191.0
HKD2_k127_4301874_36 NIPSNAP - - - 0.000000000000000000000000000000000000000000000001089 196.0
HKD2_k127_4301874_37 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000001405 174.0
HKD2_k127_4301874_38 arsenate reductase K00537 - 1.20.4.1 0.000000000000000000000000000000000000000004212 156.0
HKD2_k127_4301874_4 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 5.298e-272 861.0
HKD2_k127_4301874_40 - - - - 0.000000000000000002687 93.0
HKD2_k127_4301874_5 Sulfate permease family K03321 - - 1.013e-248 778.0
HKD2_k127_4301874_6 Carboxyl transferase domain - - - 8.999e-234 734.0
HKD2_k127_4301874_7 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 557.0
HKD2_k127_4301874_8 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 509.0
HKD2_k127_4301874_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 459.0
HKD2_k127_4313509_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 2.829e-245 758.0
HKD2_k127_4313509_1 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 1.369e-243 760.0
HKD2_k127_4313509_10 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 296.0
HKD2_k127_4313509_11 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 297.0
HKD2_k127_4313509_12 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 287.0
HKD2_k127_4313509_13 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003035 277.0
HKD2_k127_4313509_14 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001011 265.0
HKD2_k127_4313509_15 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004155 264.0
HKD2_k127_4313509_16 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001544 250.0
HKD2_k127_4313509_17 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002481 270.0
HKD2_k127_4313509_18 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000000000000000000000529 228.0
HKD2_k127_4313509_19 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000007375 217.0
HKD2_k127_4313509_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 600.0
HKD2_k127_4313509_20 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000001039 198.0
HKD2_k127_4313509_21 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000001845 196.0
HKD2_k127_4313509_22 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000001076 183.0
HKD2_k127_4313509_23 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000001518 196.0
HKD2_k127_4313509_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000009692 168.0
HKD2_k127_4313509_25 - - - - 0.000000000000000000000000000000000000000001772 167.0
HKD2_k127_4313509_26 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K00561 - 2.1.1.184 0.0000000000000000000000000000000000000007348 156.0
HKD2_k127_4313509_27 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000002086 115.0
HKD2_k127_4313509_28 rubredoxin - - - 0.00000000000000000000000008409 112.0
HKD2_k127_4313509_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 533.0
HKD2_k127_4313509_30 - - - - 0.00000001472 59.0
HKD2_k127_4313509_4 drug resistance transporter, Bcr CflA subfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 510.0
HKD2_k127_4313509_5 Methyl-transferase K18912 - 1.14.99.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 494.0
HKD2_k127_4313509_6 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 432.0
HKD2_k127_4313509_7 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 366.0
HKD2_k127_4313509_8 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 359.0
HKD2_k127_4313509_9 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 348.0
HKD2_k127_4337919_0 Glycosyl transferase family group 2 - - - 0.0 1700.0
HKD2_k127_4337919_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - 0.0 1370.0
HKD2_k127_4337919_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 531.0
HKD2_k127_4337919_11 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 535.0
HKD2_k127_4337919_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K13775 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 538.0
HKD2_k127_4337919_13 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 546.0
HKD2_k127_4337919_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 520.0
HKD2_k127_4337919_15 KR domain K13774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 495.0
HKD2_k127_4337919_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009533 492.0
HKD2_k127_4337919_17 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 476.0
HKD2_k127_4337919_18 Serine aminopeptidase, S33 K01048 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 469.0
HKD2_k127_4337919_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 470.0
HKD2_k127_4337919_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K13777 - 6.4.1.5 0.0 1060.0
HKD2_k127_4337919_20 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 434.0
HKD2_k127_4337919_21 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 424.0
HKD2_k127_4337919_22 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 393.0
HKD2_k127_4337919_23 Iron-containing alcohol dehydrogenase K00217 - 1.3.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 392.0
HKD2_k127_4337919_24 Rieske (2fe-2S) K00479 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 372.0
HKD2_k127_4337919_25 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 360.0
HKD2_k127_4337919_26 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 346.0
HKD2_k127_4337919_27 Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 327.0
HKD2_k127_4337919_28 Protein tyrosine phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 322.0
HKD2_k127_4337919_29 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 322.0
HKD2_k127_4337919_3 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K13777 - 6.4.1.5 0.0 1000.0
HKD2_k127_4337919_30 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 316.0
HKD2_k127_4337919_31 DTW K05812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 307.0
HKD2_k127_4337919_32 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001209 287.0
HKD2_k127_4337919_33 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002766 278.0
HKD2_k127_4337919_34 Phospholipid N-methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007575 270.0
HKD2_k127_4337919_35 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001387 274.0
HKD2_k127_4337919_36 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002339 248.0
HKD2_k127_4337919_37 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002298 265.0
HKD2_k127_4337919_38 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000001643 208.0
HKD2_k127_4337919_39 Sterol carrier protein - - - 0.00000000000000000000000000000000000000000000002713 171.0
HKD2_k127_4337919_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 1.077e-317 976.0
HKD2_k127_4337919_40 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000002435 150.0
HKD2_k127_4337919_41 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - 0.0000000000000000000000000000000000005655 156.0
HKD2_k127_4337919_42 Acyltransferase family - - - 0.000000000000000000000000000000000008847 151.0
HKD2_k127_4337919_43 Ankyrin repeats (many copies) - - - 0.000000000000000000000000000005762 134.0
HKD2_k127_4337919_44 Thioesterase-like superfamily K01075 - 3.1.2.23 0.000000000000000000000000003264 117.0
HKD2_k127_4337919_45 glycogen (starch) synthase activity - - - 0.0000000000000000000004931 109.0
HKD2_k127_4337919_46 Biotin-requiring enzyme - - - 0.000000000000007162 78.0
HKD2_k127_4337919_5 Pyruvate ferredoxin/flavodoxin oxidoreductase - - - 3.879e-262 814.0
HKD2_k127_4337919_6 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 7.595e-243 757.0
HKD2_k127_4337919_7 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 583.0
HKD2_k127_4337919_8 III protein, CoA-transferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 551.0
HKD2_k127_4337919_9 Conserved hypothetical protein 698 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 538.0
HKD2_k127_4341244_0 GMC oxidoreductase - - - 6.739e-282 872.0
HKD2_k127_4341244_1 Luciferase-like monooxygenase - - - 7.365e-255 787.0
HKD2_k127_4341244_10 - - - - 0.00000000000000000000000000000000000006242 147.0
HKD2_k127_4341244_11 decarboxylase - - - 0.0000000000001874 76.0
HKD2_k127_4341244_2 FAD binding domain K00480 - 1.14.13.1 3.771e-199 629.0
HKD2_k127_4341244_3 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 556.0
HKD2_k127_4341244_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 448.0
HKD2_k127_4341244_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 345.0
HKD2_k127_4341244_6 ergosterol biosynthetic process K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006037 312.0
HKD2_k127_4341244_7 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 310.0
HKD2_k127_4341244_8 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002775 249.0
HKD2_k127_4341244_9 Protein of unknown function (DUF692) K09930 - - 0.0000000000000000000000000000000000000000000000000000000000002999 227.0
HKD2_k127_4421264_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.822e-236 737.0
HKD2_k127_4421264_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 2.37e-234 732.0
HKD2_k127_4421264_2 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 3.36e-199 627.0
HKD2_k127_4421264_3 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 513.0
HKD2_k127_4421264_4 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 377.0
HKD2_k127_4421264_5 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 316.0
HKD2_k127_4437861_0 Heat shock 70 kDa protein K04043 - - 0.0 1114.0
HKD2_k127_4437861_1 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 8.042e-294 904.0
HKD2_k127_4437861_10 Haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 470.0
HKD2_k127_4437861_11 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 453.0
HKD2_k127_4437861_12 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 463.0
HKD2_k127_4437861_13 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 435.0
HKD2_k127_4437861_14 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 426.0
HKD2_k127_4437861_15 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 434.0
HKD2_k127_4437861_16 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 417.0
HKD2_k127_4437861_17 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 404.0
HKD2_k127_4437861_18 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 397.0
HKD2_k127_4437861_19 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 406.0
HKD2_k127_4437861_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.081e-249 801.0
HKD2_k127_4437861_20 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 382.0
HKD2_k127_4437861_21 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 358.0
HKD2_k127_4437861_22 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 359.0
HKD2_k127_4437861_23 transcriptional regulator K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 328.0
HKD2_k127_4437861_24 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 314.0
HKD2_k127_4437861_25 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 291.0
HKD2_k127_4437861_26 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000667 282.0
HKD2_k127_4437861_27 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003775 239.0
HKD2_k127_4437861_28 PFAM NUDIX hydrolase K08310 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008828,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019177,GO:0019438,GO:0019752,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0046872,GO:0047429,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.6.1.67 0.00000000000000000000000000000000000000000000000000000000000000000002003 237.0
HKD2_k127_4437861_29 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000000001103 173.0
HKD2_k127_4437861_3 Vacuole effluxer Atg22 like K06902 - - 1.092e-247 771.0
HKD2_k127_4437861_30 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000000000002283 161.0
HKD2_k127_4437861_31 Protein of unknown function (DUF3303) - - - 0.0000000000000000000000000000000000000005908 162.0
HKD2_k127_4437861_32 - - - - 0.0000000000000000000000003802 106.0
HKD2_k127_4437861_33 FCD - - - 0.0000000000000001119 80.0
HKD2_k127_4437861_35 Protein conserved in bacteria K09914 - - 0.000008878 56.0
HKD2_k127_4437861_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 1.443e-217 678.0
HKD2_k127_4437861_5 PFAM extracellular solute-binding protein family 5 K02035 - - 4.802e-207 656.0
HKD2_k127_4437861_6 Taurine catabolism dioxygenase TauD, TfdA family - - - 5.475e-203 641.0
HKD2_k127_4437861_7 Belongs to the peptidase S33 family K01259 - 3.4.11.5 9.141e-197 616.0
HKD2_k127_4437861_8 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 584.0
HKD2_k127_4437861_9 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 526.0
HKD2_k127_4450497_0 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 2.948e-210 663.0
HKD2_k127_4450497_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 563.0
HKD2_k127_4450497_2 Hsp20/alpha crystallin family K04080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003405 261.0
HKD2_k127_4450497_3 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000795 233.0
HKD2_k127_4450497_4 Sulfite reductase K00381 - 1.8.1.2 0.00000000000000000000000000000000000000000000000000000000000002911 215.0
HKD2_k127_4450497_5 Protein of unknown function (DUF2849) - - - 0.000000008008 64.0
HKD2_k127_4566322_0 Adenylate cyclase K01768 - 4.6.1.1 1.522e-272 849.0
HKD2_k127_4566322_1 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 535.0
HKD2_k127_4566322_10 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004871 282.0
HKD2_k127_4566322_11 COG2030 Acyl dehydratase K17865 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576 4.2.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000115 265.0
HKD2_k127_4566322_12 Transcriptional regulator, LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000937 270.0
HKD2_k127_4566322_13 Thioesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000007771 226.0
HKD2_k127_4566322_14 - - - - 0.00000000000000000000000000000000000000000000000000003623 189.0
HKD2_k127_4566322_15 Protein of unknown function (DUF1304) K08987 - - 0.0000000000000000000000000000000000003584 145.0
HKD2_k127_4566322_16 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000005999 134.0
HKD2_k127_4566322_17 - - - - 0.00004432 55.0
HKD2_k127_4566322_2 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009738 496.0
HKD2_k127_4566322_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 416.0
HKD2_k127_4566322_4 Capsular polysaccharide biosynthesis protein CapK - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 407.0
HKD2_k127_4566322_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 357.0
HKD2_k127_4566322_6 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 342.0
HKD2_k127_4566322_7 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 340.0
HKD2_k127_4566322_8 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 313.0
HKD2_k127_4566322_9 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000143 282.0
HKD2_k127_4620770_0 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 1.109e-293 904.0
HKD2_k127_4620770_1 acyl-CoA dehydrogenase K09456 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 574.0
HKD2_k127_4620770_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 462.0
HKD2_k127_4620770_3 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009589 307.0
HKD2_k127_4620770_4 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.0000000000000000000000000000000000000000000009965 176.0
HKD2_k127_4620770_5 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000002627 111.0
HKD2_k127_4631439_0 Alpha-2-Macroglobulin K06894 - - 0.0 2538.0
HKD2_k127_4631439_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.0 1099.0
HKD2_k127_4631439_10 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 424.0
HKD2_k127_4631439_11 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 399.0
HKD2_k127_4631439_12 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 374.0
HKD2_k127_4631439_13 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007794 346.0
HKD2_k127_4631439_14 Protein of unknown function (DUF1489) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001754 274.0
HKD2_k127_4631439_15 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002828 261.0
HKD2_k127_4631439_16 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000000000004689 199.0
HKD2_k127_4631439_17 YjbR - - - 0.00000000000000000000000000000000000000000000000001056 182.0
HKD2_k127_4631439_18 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 0.00000000000000000000000000000000000000000002916 161.0
HKD2_k127_4631439_19 lipolytic protein G-D-S-L family - - - 0.0001351 54.0
HKD2_k127_4631439_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 2.075e-256 810.0
HKD2_k127_4631439_3 flagellar motor protein K02557 - - 5.277e-204 640.0
HKD2_k127_4631439_4 lysyl-tRNA synthetase K04568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 585.0
HKD2_k127_4631439_5 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 595.0
HKD2_k127_4631439_6 MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 557.0
HKD2_k127_4631439_7 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 529.0
HKD2_k127_4631439_8 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 545.0
HKD2_k127_4631439_9 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 502.0
HKD2_k127_4677114_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1640.0
HKD2_k127_4677114_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0 1092.0
HKD2_k127_4677114_10 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 423.0
HKD2_k127_4677114_11 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 286.0
HKD2_k127_4677114_12 Scavenger mRNA decapping enzyme C-term binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000009041 229.0
HKD2_k127_4677114_13 protein acetylation - - - 0.0000000000000000000000000000000000000000000000000000000000003048 217.0
HKD2_k127_4677114_14 LTXXQ motif family protein - - - 0.000000000000000000000000000000000000000000000000000006578 196.0
HKD2_k127_4677114_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 4.771e-279 865.0
HKD2_k127_4677114_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K03574 - 2.7.7.18,3.6.1.55 1.032e-203 641.0
HKD2_k127_4677114_4 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 597.0
HKD2_k127_4677114_5 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000735 545.0
HKD2_k127_4677114_6 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 529.0
HKD2_k127_4677114_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 524.0
HKD2_k127_4677114_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 522.0
HKD2_k127_4677114_9 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 503.0
HKD2_k127_4682218_0 histidine kinase HAMP region domain protein K07716 - 2.7.13.3 0.0 1744.0
HKD2_k127_4682218_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.426e-224 701.0
HKD2_k127_4682218_2 mandelate racemase muconate lactonizing - - - 3.147e-208 651.0
HKD2_k127_4682218_3 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 379.0
HKD2_k127_4699838_0 Hydantoinase/oxoprolinase - - - 0.0 1186.0
HKD2_k127_4699838_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0 1142.0
HKD2_k127_4699838_10 Thiamine biosynthesis K03153 - 1.4.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000486 447.0
HKD2_k127_4699838_11 ThiF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 447.0
HKD2_k127_4699838_12 COG1702 Phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 445.0
HKD2_k127_4699838_13 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000569 421.0
HKD2_k127_4699838_14 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 433.0
HKD2_k127_4699838_15 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 382.0
HKD2_k127_4699838_16 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 372.0
HKD2_k127_4699838_17 transcriptional - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 316.0
HKD2_k127_4699838_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 311.0
HKD2_k127_4699838_19 PFAM secretion protein HlyD family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 314.0
HKD2_k127_4699838_2 Hydantoinase B/oxoprolinase - - - 0.0 1074.0
HKD2_k127_4699838_20 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 293.0
HKD2_k127_4699838_21 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 288.0
HKD2_k127_4699838_22 Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide K01725 - 4.2.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004431 276.0
HKD2_k127_4699838_23 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000179 274.0
HKD2_k127_4699838_24 Phasin protein - - - 0.000000000000000000000000000000000000000000000000000000000004348 211.0
HKD2_k127_4699838_25 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000000000000000000006385 196.0
HKD2_k127_4699838_26 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050,K15577 - - 0.000000000000000000000000000000000000000000000008034 171.0
HKD2_k127_4699838_27 Protein of unknown function (FYDLN_acid) - - - 0.0000000000000000000000000000000000000000000002518 170.0
HKD2_k127_4699838_28 long-chain fatty acid transporting porin activity K09806 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000005457 149.0
HKD2_k127_4699838_29 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000000000000000000015 146.0
HKD2_k127_4699838_3 Histidine kinase K07638 - 2.7.13.3 1.749e-252 798.0
HKD2_k127_4699838_30 Protein of unknown function (DUF2630) - - - 0.000000000000000007943 86.0
HKD2_k127_4699838_31 - - - - 0.0000007273 59.0
HKD2_k127_4699838_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 9.889e-228 711.0
HKD2_k127_4699838_5 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 2.985e-225 703.0
HKD2_k127_4699838_6 Amino-transferase class IV K00826 - 2.6.1.42 2.297e-209 653.0
HKD2_k127_4699838_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 550.0
HKD2_k127_4699838_8 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K15578 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000662 542.0
HKD2_k127_4699838_9 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006936 469.0
HKD2_k127_4743761_0 DNA ligase K01971 - 6.5.1.1 0.0 1346.0
HKD2_k127_4743761_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1290.0
HKD2_k127_4743761_10 alpha-ribazole phosphatase activity K02226,K15634,K22305,K22316 - 3.1.26.4,3.1.3.3,3.1.3.73,5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000007703 250.0
HKD2_k127_4743761_11 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K17202,K17205,K17213 - - 0.0000000000000000000000000000000000000000000000000000000001474 214.0
HKD2_k127_4743761_12 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000000000000000000000000000000000000003804 186.0
HKD2_k127_4743761_13 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000000000000000000482 171.0
HKD2_k127_4743761_14 photosystem II stabilization K02237 - - 0.00000000000000000000000000000406 124.0
HKD2_k127_4743761_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0 1051.0
HKD2_k127_4743761_3 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 2.892e-220 696.0
HKD2_k127_4743761_4 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 545.0
HKD2_k127_4743761_5 Encapsulating protein for peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008967 436.0
HKD2_k127_4743761_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 437.0
HKD2_k127_4743761_7 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 415.0
HKD2_k127_4743761_8 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 318.0
HKD2_k127_4743761_9 Chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 307.0
HKD2_k127_479279_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 6.013e-201 650.0
HKD2_k127_479279_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 452.0
HKD2_k127_479279_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001498 256.0
HKD2_k127_479279_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000003087 125.0
HKD2_k127_479279_4 GDP-mannose mannosyl hydrolase activity K01515,K03574,K12944 - 3.6.1.13,3.6.1.55 0.00000000000000000001342 97.0
HKD2_k127_4846946_0 Sulfite reductase K00381 - 1.8.1.2 3.129e-284 876.0
HKD2_k127_4846946_1 Acetolactate synthase K01576,K01652 GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6,4.1.1.7 2.052e-274 878.0
HKD2_k127_4846946_10 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000001231 224.0
HKD2_k127_4846946_11 P-aminobenzoate N-oxygenase AurF - - - 0.000000000000000000000000000000000000000000004721 176.0
HKD2_k127_4846946_12 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000001759 171.0
HKD2_k127_4846946_13 - - - - 0.00000000000000000000000000000001715 138.0
HKD2_k127_4846946_14 Bacterial protein of unknown function (DUF934) - - - 0.0000000000000000000000000000008066 128.0
HKD2_k127_4846946_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000001537 88.0
HKD2_k127_4846946_2 - - - - 2.767e-222 696.0
HKD2_k127_4846946_3 AlkA N-terminal domain K13529 - 3.2.2.21 8.731e-197 616.0
HKD2_k127_4846946_4 Animal haem peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 604.0
HKD2_k127_4846946_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009297 548.0
HKD2_k127_4846946_6 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 426.0
HKD2_k127_4846946_7 Inosine-uridine preferring nucleoside hydrolase K12700 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 399.0
HKD2_k127_4846946_8 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 385.0
HKD2_k127_4846946_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001187 270.0
HKD2_k127_4870_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.18e-262 821.0
HKD2_k127_4870_1 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 503.0
HKD2_k127_4870_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009086 370.0
HKD2_k127_4870_3 AMP-binding enzyme K12508 - 6.2.1.34 0.00000000000001221 87.0
HKD2_k127_4883747_0 SNF2 family N-terminal domain - - - 0.0 1227.0
HKD2_k127_4883747_1 Acyl-CoA dehydrogenase, middle domain - - - 1.325e-257 796.0
HKD2_k127_4883747_10 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 428.0
HKD2_k127_4883747_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 409.0
HKD2_k127_4883747_12 COG3243 Poly(3-hydroxyalkanoate) synthetase K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 350.0
HKD2_k127_4883747_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006688 252.0
HKD2_k127_4883747_14 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000004117 201.0
HKD2_k127_4883747_15 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000001903 186.0
HKD2_k127_4883747_16 - - - - 0.0000000000000000000000000000000002475 138.0
HKD2_k127_4883747_17 CoA-transferase family III - - - 0.000000000000000000000000000007172 119.0
HKD2_k127_4883747_2 Acyl-CoA dehydrogenase, middle domain - - - 6.479e-250 777.0
HKD2_k127_4883747_3 CoA-transferase family III - - - 2.101e-243 761.0
HKD2_k127_4883747_4 Acyl-CoA dehydrogenase, middle domain - - - 3.541e-228 709.0
HKD2_k127_4883747_5 Putative serine dehydratase domain - - - 9.018e-215 682.0
HKD2_k127_4883747_6 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase - - - 2.475e-212 670.0
HKD2_k127_4883747_7 CoA-transferase family III - - - 2.833e-202 645.0
HKD2_k127_4883747_8 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 512.0
HKD2_k127_4883747_9 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 529.0
HKD2_k127_4900224_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 3.089e-242 764.0
HKD2_k127_4900224_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 520.0
HKD2_k127_4900224_11 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.00000000000000003567 81.0
HKD2_k127_4900224_12 Sugar (and other) transporter K03762 - - 0.00000000000002414 75.0
HKD2_k127_4900224_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 464.0
HKD2_k127_4900224_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 431.0
HKD2_k127_4900224_4 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 436.0
HKD2_k127_4900224_5 2OG-Fe dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 409.0
HKD2_k127_4900224_6 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 332.0
HKD2_k127_4900224_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 304.0
HKD2_k127_4900224_8 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000002288 231.0
HKD2_k127_4900224_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000002075 207.0
HKD2_k127_49696_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 5.666e-266 822.0
HKD2_k127_49696_1 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 1.176e-202 637.0
HKD2_k127_49696_2 SMP-30/Gluconolaconase/LRE-like region K02352 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 552.0
HKD2_k127_49696_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 400.0
HKD2_k127_49696_4 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002383 302.0
HKD2_k127_49696_5 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000599 180.0
HKD2_k127_49696_6 TIR domain - - - 0.000000000000000000000000000000000000000000641 181.0
HKD2_k127_49696_7 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000004178 80.0
HKD2_k127_5006909_0 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 3.726e-291 914.0
HKD2_k127_5006909_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K16090 - - 3.063e-247 775.0
HKD2_k127_5006909_10 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 357.0
HKD2_k127_5006909_11 PFAM PepSY-associated TM helix domain protein K09939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 354.0
HKD2_k127_5006909_12 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 340.0
HKD2_k127_5006909_13 Belongs to the Fur family K09823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 309.0
HKD2_k127_5006909_14 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000923 293.0
HKD2_k127_5006909_15 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 289.0
HKD2_k127_5006909_16 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002741 273.0
HKD2_k127_5006909_17 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003513 272.0
HKD2_k127_5006909_18 WHG domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000445 263.0
HKD2_k127_5006909_19 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000000000000000000000009811 245.0
HKD2_k127_5006909_2 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01760 - 4.4.1.8 6.463e-246 767.0
HKD2_k127_5006909_20 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000002765 218.0
HKD2_k127_5006909_21 TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbB K03559 - - 0.000000000000000000000000000000000000000000000000000000000004679 210.0
HKD2_k127_5006909_22 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000000000000003289 206.0
HKD2_k127_5006909_24 - - - - 0.0000000000000000000000000000000000000000000000000002147 193.0
HKD2_k127_5006909_25 transcriptional regulator - - - 0.00000000000000000000000000000000000000000002417 168.0
HKD2_k127_5006909_26 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000008505 135.0
HKD2_k127_5006909_3 Major Facilitator Superfamily - - - 2.226e-198 623.0
HKD2_k127_5006909_4 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 527.0
HKD2_k127_5006909_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 493.0
HKD2_k127_5006909_6 TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 429.0
HKD2_k127_5006909_7 carbohydrate binding K07336 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 424.0
HKD2_k127_5006909_8 Threonyl and Alanyl tRNA synthetase second additional domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 424.0
HKD2_k127_5006909_9 Hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 369.0
HKD2_k127_5110561_0 Class II Aldolase and Adducin N-terminal domain - - - 0.0 1190.0
HKD2_k127_5110561_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.0 1051.0
HKD2_k127_5110561_10 Aldo keto reductase K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 595.0
HKD2_k127_5110561_11 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 580.0
HKD2_k127_5110561_12 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 561.0
HKD2_k127_5110561_13 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 513.0
HKD2_k127_5110561_14 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 475.0
HKD2_k127_5110561_15 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 462.0
HKD2_k127_5110561_16 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 441.0
HKD2_k127_5110561_17 PFAM Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 441.0
HKD2_k127_5110561_18 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 449.0
HKD2_k127_5110561_19 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 385.0
HKD2_k127_5110561_2 Proton-conducting membrane transporter - - - 5.957e-301 936.0
HKD2_k127_5110561_20 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 385.0
HKD2_k127_5110561_21 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 383.0
HKD2_k127_5110561_22 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 372.0
HKD2_k127_5110561_23 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 391.0
HKD2_k127_5110561_24 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 368.0
HKD2_k127_5110561_25 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 327.0
HKD2_k127_5110561_26 Acts on guanine, xanthine and to a lesser extent hypoxanthine K00769 - 2.4.2.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 321.0
HKD2_k127_5110561_27 oxidoreductase 20 kDa subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003583 280.0
HKD2_k127_5110561_28 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000001062 239.0
HKD2_k127_5110561_29 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.0000000000000000000000000000000000000000000000000000000003003 205.0
HKD2_k127_5110561_3 Proton-conducting membrane transporter K12141 - - 2.68e-247 770.0
HKD2_k127_5110561_30 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.000000000000000000000000000000000000000000000000000000001824 203.0
HKD2_k127_5110561_31 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000003551 211.0
HKD2_k127_5110561_33 Membrane-associated sensor, integral membrane domain - - - 0.000000000000000000000000000000000000000836 162.0
HKD2_k127_5110561_34 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000000000000000000001162 140.0
HKD2_k127_5110561_37 Response regulator receiver - - - 0.000000000000000004994 91.0
HKD2_k127_5110561_38 Pentapeptide repeats (9 copies) - - - 0.0000000000000009615 83.0
HKD2_k127_5110561_4 NADH-ubiquinone oxidoreductase chain 49kDa - - - 1.177e-246 769.0
HKD2_k127_5110561_5 PFAM amidohydrolase K07045 - - 2.945e-231 719.0
HKD2_k127_5110561_6 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 7.064e-226 707.0
HKD2_k127_5110561_7 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 4.07e-224 696.0
HKD2_k127_5110561_8 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 9.928e-224 698.0
HKD2_k127_5110561_9 COG0526, thiol-disulfide isomerase and thioredoxins - - - 9.361e-200 625.0
HKD2_k127_5113418_0 transport systems, ATPase components K02056 - 3.6.3.17 1.719e-248 775.0
HKD2_k127_5113418_1 Amidohydrolase family K01464 - 3.5.2.2 1.696e-198 629.0
HKD2_k127_5113418_2 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 553.0
HKD2_k127_5113418_3 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 558.0
HKD2_k127_5113418_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 538.0
HKD2_k127_5113418_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002437 271.0
HKD2_k127_5113418_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002313 229.0
HKD2_k127_5113418_7 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000001905 75.0
HKD2_k127_5113418_8 ABC transporter substrate binding protein K01989 - - 0.000000002629 63.0
HKD2_k127_511902_0 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 1.781e-213 684.0
HKD2_k127_511902_1 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008428 601.0
HKD2_k127_511902_2 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488,K21053 - 3.5.4.2,3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 521.0
HKD2_k127_511902_3 HAD superfamily, subfamily IIIB (Acid phosphatase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 461.0
HKD2_k127_511902_4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 435.0
HKD2_k127_511902_5 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 445.0
HKD2_k127_511902_6 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000004048 127.0
HKD2_k127_511902_7 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000002212 98.0
HKD2_k127_5127781_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.296e-270 841.0
HKD2_k127_5127781_1 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 538.0
HKD2_k127_5127781_2 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 509.0
HKD2_k127_5127781_3 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004837 457.0
HKD2_k127_5127781_4 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 377.0
HKD2_k127_5127781_5 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000203 217.0
HKD2_k127_5146508_0 HELICc2 K03722 - 3.6.4.12 0.0 1254.0
HKD2_k127_5146508_1 Beta-lactamase - - - 1.274e-249 796.0
HKD2_k127_5146508_10 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 435.0
HKD2_k127_5146508_11 Biotin-lipoyl like K03543,K15549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 420.0
HKD2_k127_5146508_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K00446 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 409.0
HKD2_k127_5146508_13 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007027 304.0
HKD2_k127_5146508_14 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004518 280.0
HKD2_k127_5146508_15 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004247 282.0
HKD2_k127_5146508_16 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000000000000269 216.0
HKD2_k127_5146508_17 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000005647 172.0
HKD2_k127_5146508_18 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.0000000000000000000000000000000000000006547 153.0
HKD2_k127_5146508_2 NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 598.0
HKD2_k127_5146508_20 D-alanyl-D-alanine carboxypeptidase K17733 - - 0.000000000000001624 89.0
HKD2_k127_5146508_22 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.00000002586 57.0
HKD2_k127_5146508_23 Protein of unknown function (DUF465) K09794 - - 0.0000000613 65.0
HKD2_k127_5146508_3 Major Facilitator Superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006431 602.0
HKD2_k127_5146508_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 571.0
HKD2_k127_5146508_5 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 545.0
HKD2_k127_5146508_6 FAD binding domain K00480,K14974 - 1.14.13.1,1.14.13.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 540.0
HKD2_k127_5146508_7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 509.0
HKD2_k127_5146508_8 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 479.0
HKD2_k127_5146508_9 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 441.0
HKD2_k127_5181311_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 5e-323 992.0
HKD2_k127_5181311_1 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 4.561e-239 754.0
HKD2_k127_5181311_10 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 423.0
HKD2_k127_5181311_11 racemase activity, acting on amino acids and derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 399.0
HKD2_k127_5181311_12 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 358.0
HKD2_k127_5181311_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 331.0
HKD2_k127_5181311_14 Branched-chain amino acid ATP-binding cassette transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001582 283.0
HKD2_k127_5181311_15 Signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001659 256.0
HKD2_k127_5181311_16 PFAM multiple antibiotic resistance (MarC)-related protein K05595 - - 0.00000000000000000000000000009708 123.0
HKD2_k127_5181311_19 carbohydrate kinase activity - - - 0.0000000000000000006881 100.0
HKD2_k127_5181311_2 Periplasmic binding protein domain - - - 1.78e-225 728.0
HKD2_k127_5181311_20 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000001632 70.0
HKD2_k127_5181311_21 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000007879 72.0
HKD2_k127_5181311_3 PFAM Acyl-CoA dehydrogenase type 2 K16047 - 1.14.14.12 8.38e-197 625.0
HKD2_k127_5181311_4 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 615.0
HKD2_k127_5181311_5 PFAM phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 568.0
HKD2_k127_5181311_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 562.0
HKD2_k127_5181311_7 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 554.0
HKD2_k127_5181311_8 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 541.0
HKD2_k127_5181311_9 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004993 486.0
HKD2_k127_5192178_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1737.0
HKD2_k127_5192178_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1691.0
HKD2_k127_5192178_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 8.47e-201 637.0
HKD2_k127_5192178_3 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 4.115e-200 622.0
HKD2_k127_5192178_4 RND efflux system, outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 427.0
HKD2_k127_5201921_0 COG0841 Cation multidrug efflux pump - - - 0.0 1763.0
HKD2_k127_5201921_1 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1437.0
HKD2_k127_5201921_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 571.0
HKD2_k127_5201921_11 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 550.0
HKD2_k127_5201921_12 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 541.0
HKD2_k127_5201921_13 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 488.0
HKD2_k127_5201921_14 Patatin-like phospholipase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 499.0
HKD2_k127_5201921_15 Diacylglycerol kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 479.0
HKD2_k127_5201921_16 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 458.0
HKD2_k127_5201921_17 Helix-turn-helix domain, rpiR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 452.0
HKD2_k127_5201921_18 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 448.0
HKD2_k127_5201921_19 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 446.0
HKD2_k127_5201921_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 8.779e-305 939.0
HKD2_k127_5201921_20 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 429.0
HKD2_k127_5201921_21 Helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 402.0
HKD2_k127_5201921_22 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 384.0
HKD2_k127_5201921_23 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 384.0
HKD2_k127_5201921_24 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 329.0
HKD2_k127_5201921_25 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 305.0
HKD2_k127_5201921_26 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 299.0
HKD2_k127_5201921_27 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004391 271.0
HKD2_k127_5201921_28 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000001471 257.0
HKD2_k127_5201921_29 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001756 210.0
HKD2_k127_5201921_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122 - 1.17.1.9 6.206e-263 820.0
HKD2_k127_5201921_30 Transcription elongation factor, GreA/GreB, C-term K06140 - - 0.000000000000000000000000000000000000000000000000000007168 195.0
HKD2_k127_5201921_31 Belongs to the UPF0310 family - - - 0.000000000000000000000000000000000000000000000000002766 186.0
HKD2_k127_5201921_32 integral membrane protein - - - 0.0000000000000000000000000000000000000001126 157.0
HKD2_k127_5201921_33 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000005164 156.0
HKD2_k127_5201921_34 transporter solute receptor, DctP family - - - 0.0000000000000000000000000000000002302 145.0
HKD2_k127_5201921_35 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000192 141.0
HKD2_k127_5201921_37 ASCH domain - - - 0.00000000000002694 78.0
HKD2_k127_5201921_38 ABC transporter permease - - - 0.00000002879 63.0
HKD2_k127_5201921_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 2.781e-257 802.0
HKD2_k127_5201921_5 FAD dependent oxidoreductase - - - 1.361e-253 786.0
HKD2_k127_5201921_6 malic enzyme K00029 - 1.1.1.40 4.464e-238 738.0
HKD2_k127_5201921_7 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 9.125e-215 671.0
HKD2_k127_5201921_8 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 617.0
HKD2_k127_5201921_9 Bacterial periplasmic substrate-binding proteins K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 578.0
HKD2_k127_5213654_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0 1563.0
HKD2_k127_5213654_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 8.823e-296 923.0
HKD2_k127_5213654_10 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 530.0
HKD2_k127_5213654_11 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 512.0
HKD2_k127_5213654_12 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 507.0
HKD2_k127_5213654_13 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 488.0
HKD2_k127_5213654_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 504.0
HKD2_k127_5213654_15 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 483.0
HKD2_k127_5213654_16 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 458.0
HKD2_k127_5213654_17 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 379.0
HKD2_k127_5213654_18 HD phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 316.0
HKD2_k127_5213654_2 AMP-binding enzyme C-terminal domain - - - 1.594e-282 873.0
HKD2_k127_5213654_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002506 238.0
HKD2_k127_5213654_21 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000003168 237.0
HKD2_k127_5213654_22 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005278 228.0
HKD2_k127_5213654_23 - - - - 0.00000000000000000000000000000000000000000001555 162.0
HKD2_k127_5213654_24 P-aminobenzoate N-oxygenase AurF - - - 0.000000000000000003335 85.0
HKD2_k127_5213654_3 P-aminobenzoate N-oxygenase AurF - - - 7.307e-211 659.0
HKD2_k127_5213654_4 Receptor family ligand binding region - - - 1.132e-208 655.0
HKD2_k127_5213654_5 Oxidoreductase NAD-binding domain K21832 - - 3.023e-197 620.0
HKD2_k127_5213654_6 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 620.0
HKD2_k127_5213654_7 Alanine dehydrogenase/PNT, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 563.0
HKD2_k127_5213654_8 Belongs to the ABC transporter superfamily K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 548.0
HKD2_k127_5213654_9 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 547.0
HKD2_k127_5269880_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 7e-323 991.0
HKD2_k127_5269880_1 Mechanosensitive ion channel - - - 1.209e-236 756.0
HKD2_k127_5269880_10 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 336.0
HKD2_k127_5269880_11 PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 312.0
HKD2_k127_5269880_12 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 292.0
HKD2_k127_5269880_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000811 247.0
HKD2_k127_5269880_14 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000000000000004349 209.0
HKD2_k127_5269880_15 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000005944 193.0
HKD2_k127_5269880_16 - - - - 0.0000000000000000000000000000000000000000000000000166 188.0
HKD2_k127_5269880_17 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000002855 181.0
HKD2_k127_5269880_18 - - - - 0.00000000000000000000000000000000000000000000000008564 196.0
HKD2_k127_5269880_19 - - - - 0.0000000000000000000000000000000000000000000001455 195.0
HKD2_k127_5269880_2 Fatty acid hydroxylase superfamily - - - 6.396e-226 708.0
HKD2_k127_5269880_20 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000003436 115.0
HKD2_k127_5269880_21 Protein of unknown function (DUF805) - - - 0.0000000000000001021 87.0
HKD2_k127_5269880_22 Integrase core domain - - - 0.00000000565 57.0
HKD2_k127_5269880_24 Concanavalin A-like lectin/glucanases superfamily - - - 0.0007277 51.0
HKD2_k127_5269880_3 peptidase M20 - - - 3.023e-218 685.0
HKD2_k127_5269880_4 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 3.356e-201 641.0
HKD2_k127_5269880_5 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 541.0
HKD2_k127_5269880_6 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009816 420.0
HKD2_k127_5269880_7 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 395.0
HKD2_k127_5269880_8 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 345.0
HKD2_k127_5269880_9 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 334.0
HKD2_k127_5287151_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 5.745e-290 907.0
HKD2_k127_5287151_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.918e-254 789.0
HKD2_k127_5287151_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000000000000000000001033 216.0
HKD2_k127_5287151_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 1.039e-242 755.0
HKD2_k127_5287151_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 569.0
HKD2_k127_5287151_4 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008608 473.0
HKD2_k127_5287151_5 carbohydrate metabolic process K09798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 411.0
HKD2_k127_5287151_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 346.0
HKD2_k127_5287151_8 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004261 253.0
HKD2_k127_5287151_9 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000000000000000000000000000001994 237.0
HKD2_k127_5310081_0 peptidylprolyl isomerase K03770 - 5.2.1.8 1.575e-309 960.0
HKD2_k127_5310081_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 9.073e-295 916.0
HKD2_k127_5310081_10 Domain of Unknown Function (DUF350) K08989 - - 0.00000000000000000000000000000000000000000000000000000000000000008954 224.0
HKD2_k127_5310081_12 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.000002231 52.0
HKD2_k127_5310081_2 ATPases associated with a variety of cellular activities K06147 - - 2.193e-281 877.0
HKD2_k127_5310081_3 Glutathionylspermidine synthase preATP-grasp - - - 4.399e-238 741.0
HKD2_k127_5310081_4 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 572.0
HKD2_k127_5310081_5 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 540.0
HKD2_k127_5310081_6 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 536.0
HKD2_k127_5310081_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 523.0
HKD2_k127_5310081_8 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 451.0
HKD2_k127_5310081_9 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 406.0
HKD2_k127_5359759_0 3-carboxy-cis,cis-muconate cycloisomerase K01857 - 5.5.1.2 4.104e-211 662.0
HKD2_k127_5359759_1 restriction endonuclease K07454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 494.0
HKD2_k127_5359759_10 Major facilitator Superfamily K08177 - - 0.000002392 52.0
HKD2_k127_5359759_2 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 437.0
HKD2_k127_5359759_3 protocatechuate 3,4-dioxygenase, beta subunit K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 400.0
HKD2_k127_5359759_4 protocatechuate 3,4-dioxygenase K00448 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 307.0
HKD2_k127_5359759_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 296.0
HKD2_k127_5359759_6 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002337 264.0
HKD2_k127_5359759_7 membrane transporter protein K07090 - - 0.0000000000000000000000000000000001488 145.0
HKD2_k127_5359759_8 - - - - 0.0000000000000001243 91.0
HKD2_k127_5359759_9 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.00000000000005185 81.0
HKD2_k127_5394607_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 0.0 1373.0
HKD2_k127_5394607_1 protein involved in outer membrane biogenesis - - - 0.0 1372.0
HKD2_k127_5394607_10 CoA-transferase family III - - - 3.53e-200 649.0
HKD2_k127_5394607_11 Protein of unknown function (DUF1254) - - - 2.386e-198 636.0
HKD2_k127_5394607_12 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 7.613e-198 637.0
HKD2_k127_5394607_13 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 550.0
HKD2_k127_5394607_14 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 530.0
HKD2_k127_5394607_15 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000514 527.0
HKD2_k127_5394607_16 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 516.0
HKD2_k127_5394607_17 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 509.0
HKD2_k127_5394607_18 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 507.0
HKD2_k127_5394607_19 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 484.0
HKD2_k127_5394607_2 amine dehydrogenase activity K03418 - 3.5.1.56 0.0 1281.0
HKD2_k127_5394607_20 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 465.0
HKD2_k127_5394607_21 Belongs to the BI1 family K06890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 433.0
HKD2_k127_5394607_22 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 419.0
HKD2_k127_5394607_23 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 418.0
HKD2_k127_5394607_24 AAA ATPase K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 404.0
HKD2_k127_5394607_25 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009099 400.0
HKD2_k127_5394607_26 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 368.0
HKD2_k127_5394607_27 NMT1-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 340.0
HKD2_k127_5394607_28 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 342.0
HKD2_k127_5394607_29 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 318.0
HKD2_k127_5394607_3 GTP-binding protein TypA K06207 - - 0.0 1054.0
HKD2_k127_5394607_30 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 293.0
HKD2_k127_5394607_31 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004716 287.0
HKD2_k127_5394607_32 Stringent starvation protein B K09985 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008031 275.0
HKD2_k127_5394607_33 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002709 274.0
HKD2_k127_5394607_34 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000004142 232.0
HKD2_k127_5394607_35 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000006647 211.0
HKD2_k127_5394607_36 membrane protein domain - - - 0.0000000000000000000000000000000000000000000000000001662 207.0
HKD2_k127_5394607_37 COG3663 G T U mismatch-specific DNA glycosylase K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000064 175.0
HKD2_k127_5394607_38 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000009789 161.0
HKD2_k127_5394607_39 THIoesterase K18700 - 3.1.2.29 0.0000000000000000000000000000435 120.0
HKD2_k127_5394607_4 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.0 1036.0
HKD2_k127_5394607_40 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000003717 114.0
HKD2_k127_5394607_41 - - - - 0.00000000000000000000008737 107.0
HKD2_k127_5394607_42 - - - - 0.000000000000000000000682 96.0
HKD2_k127_5394607_43 Cytochrome c - - - 0.0000000000000000000007188 99.0
HKD2_k127_5394607_44 Ribbon-helix-helix domain - - - 0.00000000000000000001059 95.0
HKD2_k127_5394607_45 - - - - 0.000000000000959 77.0
HKD2_k127_5394607_46 Domain of unknown function (DUF4169) - - - 0.000000004724 69.0
HKD2_k127_5394607_47 - - - - 0.00000003099 67.0
HKD2_k127_5394607_49 - - - - 0.0000002702 63.0
HKD2_k127_5394607_5 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 1.575e-291 899.0
HKD2_k127_5394607_52 - - - - 0.000009908 55.0
HKD2_k127_5394607_53 - - - - 0.00001881 53.0
HKD2_k127_5394607_6 Acyl-CoA dehydrogenase, C-terminal domain K06446 - - 6.169e-239 750.0
HKD2_k127_5394607_7 Acyl-CoA dehydrogenase, middle domain - - - 7.621e-237 746.0
HKD2_k127_5394607_8 III protein, CoA-transferase family - - - 9.089e-220 694.0
HKD2_k127_5394607_9 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 2.103e-203 636.0
HKD2_k127_543097_0 DNA polymerase beta thumb K02347 - - 5.01e-212 673.0
HKD2_k127_543097_1 Nicotinate phosphoribosyltransferase (NAPRTase) family K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 561.0
HKD2_k127_543097_2 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 426.0
HKD2_k127_543097_3 PFAM UspA domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 287.0
HKD2_k127_543097_4 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005868 271.0
HKD2_k127_543097_5 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000002267 153.0
HKD2_k127_543097_6 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000005692 135.0
HKD2_k127_5463621_0 Flavin-binding monooxygenase-like - - - 1.418e-279 865.0
HKD2_k127_5463621_1 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 434.0
HKD2_k127_5463621_2 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 359.0
HKD2_k127_5463621_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 338.0
HKD2_k127_5463621_4 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 301.0
HKD2_k127_5463621_5 Nitrile hydratase beta subunit - - - 0.0000000000000000000000000000000000000000000000000000005483 203.0
HKD2_k127_5463621_6 AMP-binding enzyme C-terminal domain K00666,K18688 - 6.2.1.42 0.0002817 44.0
HKD2_k127_5472142_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 6.582e-318 983.0
HKD2_k127_5472142_1 Protein of unknown function (DUF445) - - - 2.742e-231 720.0
HKD2_k127_5472142_12 Uncharacterized protein family UPF0016 - - - 0.00007066 46.0
HKD2_k127_5472142_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.826e-224 702.0
HKD2_k127_5472142_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 531.0
HKD2_k127_5472142_4 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 499.0
HKD2_k127_5472142_5 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 451.0
HKD2_k127_5472142_6 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 401.0
HKD2_k127_5472142_7 Phasin protein - - - 0.0000000000000000000000000000000000000000000000000000000000000007168 221.0
HKD2_k127_5472142_9 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid K00020 - 1.1.1.31 0.000000000000000000000000000000008063 128.0
HKD2_k127_5472544_0 Hydantoinase B/oxoprolinase - - - 0.0 1023.0
HKD2_k127_5472544_1 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 0.0 1009.0
HKD2_k127_5472544_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 338.0
HKD2_k127_5472544_11 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002361 258.0
HKD2_k127_5472544_12 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000001125 247.0
HKD2_k127_5472544_13 Peptidase M15A K03791 - - 0.0000000000000000000000000000000000000000000000000000000000000000001973 232.0
HKD2_k127_5472544_14 protein possibly involved in utilization of glycolate and propanediol - - - 0.0000000000000000000000000000000000000000000000000000000000000007593 222.0
HKD2_k127_5472544_15 ATP-dependent Clp protease adaptor protein ClpS - - - 0.00000000000000000000000000000000000000001358 155.0
HKD2_k127_5472544_16 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000001941 66.0
HKD2_k127_5472544_2 ABC-type Fe3 transport system permease component K02011 - - 1.68e-301 932.0
HKD2_k127_5472544_3 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 8.678e-267 826.0
HKD2_k127_5472544_4 Bacterial extracellular solute-binding protein K02012 - - 1.611e-198 622.0
HKD2_k127_5472544_5 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000746 577.0
HKD2_k127_5472544_6 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 462.0
HKD2_k127_5472544_7 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008343 457.0
HKD2_k127_5472544_8 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007541 438.0
HKD2_k127_5472544_9 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 353.0
HKD2_k127_5478134_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1146.0
HKD2_k127_5478134_1 COG0457 FOG TPR repeat - - - 6.724e-259 803.0
HKD2_k127_5478134_10 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 418.0
HKD2_k127_5478134_11 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 398.0
HKD2_k127_5478134_12 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 323.0
HKD2_k127_5478134_13 Adenylate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008314 282.0
HKD2_k127_5478134_14 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002648 273.0
HKD2_k127_5478134_15 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002987 272.0
HKD2_k127_5478134_16 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.0000000000000000000000000000000000000000000000000000001149 201.0
HKD2_k127_5478134_17 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.00000000000000000000000000000000000000000000000001942 182.0
HKD2_k127_5478134_2 carnitine dehydratase K07749 - 2.8.3.16 2.132e-219 684.0
HKD2_k127_5478134_3 COG2030 Acyl dehydratase K14449 - 4.2.1.148 9.058e-205 641.0
HKD2_k127_5478134_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 5.642e-200 625.0
HKD2_k127_5478134_5 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 544.0
HKD2_k127_5478134_6 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 515.0
HKD2_k127_5478134_7 carnitine dehydratase K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 489.0
HKD2_k127_5478134_8 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 478.0
HKD2_k127_5478134_9 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP K00868 - 2.7.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 470.0
HKD2_k127_5495024_0 Sodium/hydrogen exchanger family - - - 3.238e-291 909.0
HKD2_k127_5495024_1 Hydrolyzes N-terminal residues in D-amino acid- containing peptides K01266 - 3.4.11.19 1.109e-263 820.0
HKD2_k127_5495024_10 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 543.0
HKD2_k127_5495024_11 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 480.0
HKD2_k127_5495024_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 440.0
HKD2_k127_5495024_13 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 404.0
HKD2_k127_5495024_14 COG3279 Response regulator of the LytR AlgR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 398.0
HKD2_k127_5495024_15 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 390.0
HKD2_k127_5495024_16 Polyhydroxyalkanoate synthesis repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 360.0
HKD2_k127_5495024_17 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 357.0
HKD2_k127_5495024_18 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 357.0
HKD2_k127_5495024_19 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 329.0
HKD2_k127_5495024_2 Luciferase-like monooxygenase - - - 3.438e-260 806.0
HKD2_k127_5495024_20 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 306.0
HKD2_k127_5495024_21 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 289.0
HKD2_k127_5495024_22 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006459 280.0
HKD2_k127_5495024_23 Protein of unknown function (DUF1348) K09958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003106 269.0
HKD2_k127_5495024_24 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000007911 265.0
HKD2_k127_5495024_25 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000401 244.0
HKD2_k127_5495024_26 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000001949 207.0
HKD2_k127_5495024_27 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000002802 222.0
HKD2_k127_5495024_28 PFAM FMN-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000002863 218.0
HKD2_k127_5495024_3 Amidase - - - 2.946e-257 800.0
HKD2_k127_5495024_30 - - - - 0.000000000000000000000000005466 117.0
HKD2_k127_5495024_32 Fe-S protein K06938 - - 0.00000000000000007373 88.0
HKD2_k127_5495024_33 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000004547 74.0
HKD2_k127_5495024_34 - - - - 0.0000000002118 67.0
HKD2_k127_5495024_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.538e-255 805.0
HKD2_k127_5495024_5 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 1.864e-213 668.0
HKD2_k127_5495024_6 alpha/beta hydrolase fold K03821 - - 7.346e-211 662.0
HKD2_k127_5495024_7 Belongs to the thiolase family K00626 - 2.3.1.9 4.993e-198 623.0
HKD2_k127_5495024_8 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 591.0
HKD2_k127_5495024_9 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 576.0
HKD2_k127_5505728_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 596.0
HKD2_k127_5505728_1 Phosphoenolpyruvate phosphomutase K20454 - 4.1.3.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 383.0
HKD2_k127_5505728_2 cation efflux K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000148 270.0
HKD2_k127_5505728_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000001251 169.0
HKD2_k127_5505728_4 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000000003766 126.0
HKD2_k127_5556863_0 COG0841 Cation multidrug efflux pump K03296 - - 0.0 1084.0
HKD2_k127_5556863_1 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 437.0
HKD2_k127_5556863_2 transposable element conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000001425 226.0
HKD2_k127_5556863_3 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000000000000000000000000000000000000000000003037 214.0
HKD2_k127_5556863_4 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000000000000000000000000000000006698 186.0
HKD2_k127_5556863_5 Winged helix-turn helix - - - 0.00000000000000000000000000000000000000000000004129 175.0
HKD2_k127_5577821_0 Peptidase dimerisation domain - - - 5.087e-217 676.0
HKD2_k127_5577821_1 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 1.88e-209 657.0
HKD2_k127_5577821_2 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 586.0
HKD2_k127_5577821_3 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 434.0
HKD2_k127_5577821_4 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 419.0
HKD2_k127_5577821_5 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000003216 139.0
HKD2_k127_5578357_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 2.034e-320 988.0
HKD2_k127_5578357_1 Major Facilitator Superfamily K03446 - - 1.335e-297 917.0
HKD2_k127_5578357_10 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 579.0
HKD2_k127_5578357_11 lysine 2,3-aminomutase K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 576.0
HKD2_k127_5578357_12 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 557.0
HKD2_k127_5578357_13 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 564.0
HKD2_k127_5578357_14 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 480.0
HKD2_k127_5578357_15 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 489.0
HKD2_k127_5578357_16 secretion protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 461.0
HKD2_k127_5578357_17 EamA-like transporter family K15268 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 453.0
HKD2_k127_5578357_18 Aconitase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 370.0
HKD2_k127_5578357_19 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 341.0
HKD2_k127_5578357_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 9.621e-292 900.0
HKD2_k127_5578357_20 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004262 253.0
HKD2_k127_5578357_21 HlyD membrane-fusion protein of T1SS K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005544 252.0
HKD2_k127_5578357_22 Transcriptional regulator K03566 - - 0.0000000000000000000000000000000000001752 145.0
HKD2_k127_5578357_23 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000000377 130.0
HKD2_k127_5578357_24 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000006224 125.0
HKD2_k127_5578357_25 Domain of unknown function (DUF1127) - - - 0.0000000000000000000007188 99.0
HKD2_k127_5578357_26 Domain of unknown function (DUF1127) - - - 0.00000008698 55.0
HKD2_k127_5578357_3 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 2.987e-277 860.0
HKD2_k127_5578357_4 Peptidase dimerisation domain K01438 - 3.5.1.16 1.211e-274 846.0
HKD2_k127_5578357_5 Aconitase family (aconitate hydratase) - - - 3.545e-263 815.0
HKD2_k127_5578357_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K13926 - - 4.469e-206 651.0
HKD2_k127_5578357_7 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 4.257e-205 643.0
HKD2_k127_5578357_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K13926 - - 2.204e-201 636.0
HKD2_k127_5578357_9 peptidyl-tyrosine sulfation - - - 2.89e-196 621.0
HKD2_k127_5589804_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.87e-322 989.0
HKD2_k127_5589804_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 9.716e-318 975.0
HKD2_k127_5589804_10 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 356.0
HKD2_k127_5589804_11 Putative bacterial sensory transduction regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 306.0
HKD2_k127_5589804_12 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001691 242.0
HKD2_k127_5589804_13 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050,K15577 - - 0.00000000000000000000000000000000000000000000000001833 190.0
HKD2_k127_5589804_14 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051,K15576 - - 0.000000000000000000000000000000000001189 143.0
HKD2_k127_5589804_15 Dodecin K09165 - - 0.00000000000000000000001163 103.0
HKD2_k127_5589804_2 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 1.489e-316 975.0
HKD2_k127_5589804_3 NMT1-like family K15576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009815 579.0
HKD2_k127_5589804_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 539.0
HKD2_k127_5589804_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 521.0
HKD2_k127_5589804_6 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 503.0
HKD2_k127_5589804_7 acyl-CoA dehydrogenase K09456 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 424.0
HKD2_k127_5589804_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 393.0
HKD2_k127_5600742_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789 - - 0.0 1109.0
HKD2_k127_5600742_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K08191 - - 2.103e-196 627.0
HKD2_k127_5600742_10 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 332.0
HKD2_k127_5600742_11 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002489 284.0
HKD2_k127_5600742_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000004887 241.0
HKD2_k127_5600742_13 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000001809 230.0
HKD2_k127_5600742_14 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000002944 212.0
HKD2_k127_5600742_15 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000001387 196.0
HKD2_k127_5600742_16 MMPL family K07789 - - 0.00000000000000000000000000000000000000000000002336 175.0
HKD2_k127_5600742_17 hydrolase family 81 - - - 0.00000000000000000000000000000000000000000006439 186.0
HKD2_k127_5600742_18 - - - - 0.00000000000000000000000000000000000000000007109 165.0
HKD2_k127_5600742_19 Cysteine dioxygenase type I - - - 0.000000000000000000000000002058 115.0
HKD2_k127_5600742_2 Sodium/calcium exchanger protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 496.0
HKD2_k127_5600742_20 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000004822 108.0
HKD2_k127_5600742_21 Lysozyme inhibitor LprI - - - 0.0000000000000000000000101 108.0
HKD2_k127_5600742_22 Peptidase S24-like - - - 0.0000000000000000000002111 105.0
HKD2_k127_5600742_24 Transposase DDE domain - - - 0.000000000005379 65.0
HKD2_k127_5600742_3 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 443.0
HKD2_k127_5600742_4 ribonuclease inhibitor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 417.0
HKD2_k127_5600742_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008393 392.0
HKD2_k127_5600742_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 389.0
HKD2_k127_5600742_7 ABC-type tungstate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 340.0
HKD2_k127_5600742_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799,K18990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 323.0
HKD2_k127_5600742_9 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 323.0
HKD2_k127_5606966_0 Mechanosensitive ion channel - - - 1.635e-253 801.0
HKD2_k127_5606966_1 Metallo-beta-lactamase superfamily - - - 1.204e-215 671.0
HKD2_k127_5606966_2 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 551.0
HKD2_k127_5606966_3 Aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 514.0
HKD2_k127_5606966_4 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000001517 222.0
HKD2_k127_5614134_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 8.433e-277 853.0
HKD2_k127_5614134_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 1.648e-258 809.0
HKD2_k127_5614134_10 Protein of unknown function (DUF559) - - - 0.0000000000000000000000251 105.0
HKD2_k127_5614134_11 - - - - 0.0000000000000009291 84.0
HKD2_k127_5614134_12 Protein of unknown function (DUF3987) - - - 0.000000000000005193 87.0
HKD2_k127_5614134_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 469.0
HKD2_k127_5614134_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 471.0
HKD2_k127_5614134_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 467.0
HKD2_k127_5614134_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001785 295.0
HKD2_k127_5614134_6 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002715 281.0
HKD2_k127_5614134_7 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005248 244.0
HKD2_k127_5614134_8 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001379 246.0
HKD2_k127_5614134_9 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000004098 209.0
HKD2_k127_5635486_0 In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 366.0
HKD2_k127_5635486_1 Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate K09018 GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.14.99.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 352.0
HKD2_k127_5635486_2 May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation K09021 - - 0.000000000000000000000000000000000000000000000000000000000007555 209.0
HKD2_k127_5635486_3 ABC transporter substrate-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000003026 216.0
HKD2_k127_5635486_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000001138 162.0
HKD2_k127_5635486_5 - - - - 0.0000000857 53.0
HKD2_k127_5635486_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000003336 63.0
HKD2_k127_5667723_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0 1589.0
HKD2_k127_5667723_1 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.0 1461.0
HKD2_k127_5667723_10 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 601.0
HKD2_k127_5667723_11 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 547.0
HKD2_k127_5667723_12 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 539.0
HKD2_k127_5667723_13 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 517.0
HKD2_k127_5667723_14 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 484.0
HKD2_k127_5667723_15 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 458.0
HKD2_k127_5667723_16 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 448.0
HKD2_k127_5667723_17 Peptidase family S49 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 399.0
HKD2_k127_5667723_18 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 361.0
HKD2_k127_5667723_19 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 347.0
HKD2_k127_5667723_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 6.03e-322 990.0
HKD2_k127_5667723_20 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 346.0
HKD2_k127_5667723_21 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 341.0
HKD2_k127_5667723_22 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 334.0
HKD2_k127_5667723_23 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 338.0
HKD2_k127_5667723_24 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 299.0
HKD2_k127_5667723_25 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003721 279.0
HKD2_k127_5667723_26 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009968 277.0
HKD2_k127_5667723_27 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000003075 248.0
HKD2_k127_5667723_28 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000000000000000000000000000002354 231.0
HKD2_k127_5667723_29 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000000000000007605 217.0
HKD2_k127_5667723_3 COG0642 Signal transduction histidine kinase K14980 - 2.7.13.3 4.864e-309 956.0
HKD2_k127_5667723_30 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism K06023 - - 0.0000000000000000000000000000000000000000000000000000003744 202.0
HKD2_k127_5667723_32 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.000000000000000000000000000000000000001324 155.0
HKD2_k127_5667723_4 Adenylate cyclase - - - 1.877e-308 954.0
HKD2_k127_5667723_5 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.525e-294 908.0
HKD2_k127_5667723_6 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 4.507e-280 873.0
HKD2_k127_5667723_7 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.156e-226 710.0
HKD2_k127_5667723_8 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 6.74e-216 677.0
HKD2_k127_5667723_9 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 1.311e-196 616.0
HKD2_k127_5672936_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 4.851e-266 835.0
HKD2_k127_5672936_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 4.299e-259 811.0
HKD2_k127_5672936_10 Thiamine pyrophosphate enzyme, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 318.0
HKD2_k127_5672936_11 AAA domain, putative AbiEii toxin, Type IV TA system K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 314.0
HKD2_k127_5672936_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009957 296.0
HKD2_k127_5672936_13 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001068 288.0
HKD2_k127_5672936_14 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003628 275.0
HKD2_k127_5672936_15 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006582 267.0
HKD2_k127_5672936_16 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000001712 274.0
HKD2_k127_5672936_17 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002717 238.0
HKD2_k127_5672936_18 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000002555 231.0
HKD2_k127_5672936_19 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000006078 220.0
HKD2_k127_5672936_2 COG0402 Cytosine deaminase and related metal-dependent hydrolases K01485 - 3.5.4.1 2.492e-196 619.0
HKD2_k127_5672936_20 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000002442 211.0
HKD2_k127_5672936_21 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000672 211.0
HKD2_k127_5672936_22 Globin - - - 0.000000000000000000000000000000000000000000000000165 183.0
HKD2_k127_5672936_23 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000007764 188.0
HKD2_k127_5672936_24 Lipocalin-like domain - - - 0.00000000000000000000000000000008975 136.0
HKD2_k127_5672936_25 Endoribonuclease L-PSP - - - 0.00000000000000000000000007001 111.0
HKD2_k127_5672936_26 Peptidoglycan-binding domain 1 protein - - - 0.000000000000007242 85.0
HKD2_k127_5672936_27 - - - - 0.0000000271 60.0
HKD2_k127_5672936_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 524.0
HKD2_k127_5672936_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 462.0
HKD2_k127_5672936_5 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 357.0
HKD2_k127_5672936_6 branched-chain amino acid K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 348.0
HKD2_k127_5672936_7 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 347.0
HKD2_k127_5672936_8 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 329.0
HKD2_k127_5672936_9 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 326.0
HKD2_k127_5680590_0 Dehydratase family K22186 - 4.2.1.82 0.0 1104.0
HKD2_k127_5680590_1 transport system fused permease components - - - 1.063e-256 811.0
HKD2_k127_5680590_10 membrane K08985 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 447.0
HKD2_k127_5680590_11 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 421.0
HKD2_k127_5680590_12 Enoyl-(Acyl carrier protein) reductase K18335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 419.0
HKD2_k127_5680590_13 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 359.0
HKD2_k127_5680590_14 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003564 277.0
HKD2_k127_5680590_15 Protein conserved in bacteria K09966 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005927 246.0
HKD2_k127_5680590_17 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000000000000000000000000000001007 230.0
HKD2_k127_5680590_18 Cold shock protein domain - - - 0.00000000000000000000000000000000000000000000000000000002051 201.0
HKD2_k127_5680590_19 ETC complex I subunit conserved region - - - 0.000000000000000000000000000000000000000000000000002624 184.0
HKD2_k127_5680590_2 Reductase C-terminal K05297 - 1.18.1.1 2.172e-239 750.0
HKD2_k127_5680590_20 PFAM PfkB domain protein K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000004839 190.0
HKD2_k127_5680590_21 Ketosteroid isomerase-related protein - - - 0.000000000000000000000000003224 119.0
HKD2_k127_5680590_3 Rieske 2Fe-2S - - - 5.661e-202 633.0
HKD2_k127_5680590_4 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 554.0
HKD2_k127_5680590_5 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 550.0
HKD2_k127_5680590_6 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 544.0
HKD2_k127_5680590_7 Chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 544.0
HKD2_k127_5680590_8 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 510.0
HKD2_k127_5680590_9 Sir2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 449.0
HKD2_k127_5697696_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 9.036e-244 756.0
HKD2_k127_5697696_1 PFAM peptidase S15 K06978 - - 1.127e-241 762.0
HKD2_k127_5697696_11 - - - - 0.00005778 55.0
HKD2_k127_5697696_12 GDSL-like Lipase/Acylhydrolase family - - - 0.0001846 53.0
HKD2_k127_5697696_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004377 453.0
HKD2_k127_5697696_3 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007922 437.0
HKD2_k127_5697696_4 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 381.0
HKD2_k127_5697696_5 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 377.0
HKD2_k127_5697696_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 372.0
HKD2_k127_5697696_7 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 291.0
HKD2_k127_5697696_8 Domain of unknown function (DUF4864) - - - 0.00000000000000000000000000000000000000000000000000000000000000006949 225.0
HKD2_k127_5933801_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1793.0
HKD2_k127_5933801_1 acyl-CoA dehydrogenase - - - 1.231e-244 758.0
HKD2_k127_5933801_10 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001205 265.0
HKD2_k127_5933801_11 probably involved in intracellular septation - - - 0.000000000000000000000000000000000000000000000000000000000002045 214.0
HKD2_k127_5933801_2 CoA-transferase family III - - - 1.071e-214 690.0
HKD2_k127_5933801_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 596.0
HKD2_k127_5933801_4 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 572.0
HKD2_k127_5933801_5 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 552.0
HKD2_k127_5933801_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 477.0
HKD2_k127_5933801_7 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 449.0
HKD2_k127_5933801_8 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 291.0
HKD2_k127_5933801_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003874 271.0
HKD2_k127_608216_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1603.0
HKD2_k127_608216_1 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.0 1400.0
HKD2_k127_608216_10 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 418.0
HKD2_k127_608216_11 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 415.0
HKD2_k127_608216_12 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 404.0
HKD2_k127_608216_13 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009271 385.0
HKD2_k127_608216_14 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 287.0
HKD2_k127_608216_15 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000001945 276.0
HKD2_k127_608216_16 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000005568 149.0
HKD2_k127_608216_17 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000004588 152.0
HKD2_k127_608216_18 PFAM Mo-dependent nitrogenase - - - 0.00000000000000000000000000000001808 134.0
HKD2_k127_608216_19 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000000000000000000000005717 130.0
HKD2_k127_608216_2 Protein of unknown function - - - 0.0 1358.0
HKD2_k127_608216_21 Sugar (and other) transporter - - - 0.00000000000000000000000001004 111.0
HKD2_k127_608216_22 - - - - 0.00000000000000000601 100.0
HKD2_k127_608216_24 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.00000000002217 74.0
HKD2_k127_608216_25 PFAM Mo-dependent nitrogenase - - - 0.000005224 55.0
HKD2_k127_608216_3 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 3.103e-313 971.0
HKD2_k127_608216_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 1.348e-233 731.0
HKD2_k127_608216_5 FAD binding domain - - - 2.041e-213 672.0
HKD2_k127_608216_6 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 571.0
HKD2_k127_608216_7 PFAM amidohydrolase 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000843 500.0
HKD2_k127_608216_8 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 533.0
HKD2_k127_608216_9 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 429.0
HKD2_k127_6148521_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1454.0
HKD2_k127_6148521_1 TAP-like protein - - - 7.863e-272 848.0
HKD2_k127_6148521_10 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002885 276.0
HKD2_k127_6148521_12 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004121 247.0
HKD2_k127_6148521_13 NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000002534 241.0
HKD2_k127_6148521_15 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000004873 146.0
HKD2_k127_6148521_2 Proton-conducting membrane transporter - - - 1.116e-253 799.0
HKD2_k127_6148521_3 Major Facilitator Superfamily - - - 5.379e-241 749.0
HKD2_k127_6148521_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 1.006e-217 678.0
HKD2_k127_6148521_5 Proton-conducting membrane transporter K12141 - - 1.705e-206 655.0
HKD2_k127_6148521_6 NADH-ubiquinone oxidoreductase chain 49kDa - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 612.0
HKD2_k127_6148521_7 transcriptional - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 511.0
HKD2_k127_6148521_8 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 477.0
HKD2_k127_6148521_9 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 422.0
HKD2_k127_6410045_0 COG1960 Acyl-CoA dehydrogenases K20035 - - 0.0 1103.0
HKD2_k127_6410045_1 Protein tyrosine kinase - - - 2.806e-272 849.0
HKD2_k127_6410045_10 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 467.0
HKD2_k127_6410045_11 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000955 444.0
HKD2_k127_6410045_12 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 352.0
HKD2_k127_6410045_13 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001444 266.0
HKD2_k127_6410045_14 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000008161 221.0
HKD2_k127_6410045_16 acetyltransferase K06966 - 3.2.2.10 0.000000000000000000000000000000000000004011 151.0
HKD2_k127_6410045_2 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 2.677e-267 827.0
HKD2_k127_6410045_3 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 3.221e-247 765.0
HKD2_k127_6410045_4 Cytochrome P450 - - - 2.504e-221 693.0
HKD2_k127_6410045_5 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 575.0
HKD2_k127_6410045_6 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 519.0
HKD2_k127_6410045_7 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 539.0
HKD2_k127_6410045_8 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 505.0
HKD2_k127_6410045_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 496.0
HKD2_k127_6428270_0 Histidine kinase - - - 0.0 1596.0
HKD2_k127_6428270_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 1.557e-282 880.0
HKD2_k127_6428270_11 - - - - 0.00004926 57.0
HKD2_k127_6428270_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007891 552.0
HKD2_k127_6428270_3 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 472.0
HKD2_k127_6428270_4 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 449.0
HKD2_k127_6428270_5 carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009693 336.0
HKD2_k127_6428270_6 WYL domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002142 282.0
HKD2_k127_6428270_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001576 280.0
HKD2_k127_6428270_8 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007392 251.0
HKD2_k127_6428270_9 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000007676 232.0
HKD2_k127_6438026_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K00166,K21416 - 1.2.4.1,1.2.4.4 1.305e-245 761.0
HKD2_k127_6438026_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 1.85e-241 752.0
HKD2_k127_6438026_2 Transketolase, pyrimidine binding domain K21417 - - 9.53e-208 671.0
HKD2_k127_6438026_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) - - - 1.353e-198 628.0
HKD2_k127_6438026_4 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 580.0
HKD2_k127_6438026_5 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 578.0
HKD2_k127_6438026_6 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 530.0
HKD2_k127_6438026_7 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 525.0
HKD2_k127_6438026_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 387.0
HKD2_k127_6438026_9 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000001535 213.0
HKD2_k127_6443284_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1813.0
HKD2_k127_6443284_1 - K13582,K13924,K15580 - 2.1.1.80,3.1.1.61 0.0 1454.0
HKD2_k127_6443284_10 glutamine synthetase K01915 - 6.3.1.2 1.74e-274 869.0
HKD2_k127_6443284_100 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000004337 253.0
HKD2_k127_6443284_101 COG1309 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001 248.0
HKD2_k127_6443284_102 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002368 249.0
HKD2_k127_6443284_103 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006833 241.0
HKD2_k127_6443284_104 COG1309 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000003732 241.0
HKD2_k127_6443284_106 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.0000000000000000000000000000000000000000000000000000000000000145 217.0
HKD2_k127_6443284_107 MafB19-like deaminase K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000521 213.0
HKD2_k127_6443284_108 - - - - 0.0000000000000000000000000000000000000000000000000000000000005218 214.0
HKD2_k127_6443284_109 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000000000000007242 214.0
HKD2_k127_6443284_11 ATPase involved in DNA repair K13924 - 2.1.1.80,3.1.1.61 2.167e-274 884.0
HKD2_k127_6443284_110 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000003152 205.0
HKD2_k127_6443284_111 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000002736 209.0
HKD2_k127_6443284_113 Belongs to the HesB IscA family K15724 - - 0.00000000000000000000000000000000000000000000000000000006704 199.0
HKD2_k127_6443284_114 Cupin - - - 0.000000000000000000000000000000000000000000000000000000225 196.0
HKD2_k127_6443284_115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000006547 153.0
HKD2_k127_6443284_116 transposase activity - - - 0.000000000000000000000000000000000003785 149.0
HKD2_k127_6443284_117 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000000000143 147.0
HKD2_k127_6443284_118 Cupin domain - - - 0.0000000000000000000000000000000006561 141.0
HKD2_k127_6443284_119 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000003213 132.0
HKD2_k127_6443284_12 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 1.826e-269 833.0
HKD2_k127_6443284_120 - - - - 0.00000000000000000000000000000001863 144.0
HKD2_k127_6443284_123 Redoxin - - - 0.0000000001348 73.0
HKD2_k127_6443284_124 - - - - 0.0000000009924 64.0
HKD2_k127_6443284_125 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000005089 65.0
HKD2_k127_6443284_13 Amidase - - - 2.557e-265 827.0
HKD2_k127_6443284_131 Phospholipase D. Active site motifs. - - - 0.0007077 51.0
HKD2_k127_6443284_14 Belongs to the amidase family - - - 1.878e-263 827.0
HKD2_k127_6443284_15 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 5.291e-254 787.0
HKD2_k127_6443284_16 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.97e-251 779.0
HKD2_k127_6443284_17 Aspartate tyrosine aromatic aminotransferase - - - 2.367e-233 724.0
HKD2_k127_6443284_18 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 9.656e-227 722.0
HKD2_k127_6443284_19 acyl-CoA dehydrogenase K00249 - 1.3.8.7 6.576e-226 702.0
HKD2_k127_6443284_2 beta (1-6) glucans synthase - - - 0.0 1135.0
HKD2_k127_6443284_20 Protein of unknown function (DUF2817) - - - 1.052e-218 681.0
HKD2_k127_6443284_21 COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - - 8.08e-217 677.0
HKD2_k127_6443284_22 Sulfate permease family - - - 5.191e-211 669.0
HKD2_k127_6443284_23 L-carnitine dehydratase bile acid-inducible protein - - - 4.835e-209 655.0
HKD2_k127_6443284_24 Zinc-binding dehydrogenase K00001,K00344 - 1.1.1.1,1.6.5.5 1.846e-199 622.0
HKD2_k127_6443284_25 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 7.362e-198 629.0
HKD2_k127_6443284_26 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 6.613e-195 620.0
HKD2_k127_6443284_27 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 604.0
HKD2_k127_6443284_28 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 597.0
HKD2_k127_6443284_29 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 601.0
HKD2_k127_6443284_3 mitochondrial gene expression - - - 0.0 1119.0
HKD2_k127_6443284_30 COG3540 Phosphodiesterase alkaline phosphatase D K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 590.0
HKD2_k127_6443284_31 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 586.0
HKD2_k127_6443284_32 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 604.0
HKD2_k127_6443284_33 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 591.0
HKD2_k127_6443284_34 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 589.0
HKD2_k127_6443284_35 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 576.0
HKD2_k127_6443284_36 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 571.0
HKD2_k127_6443284_37 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 590.0
HKD2_k127_6443284_38 Methionine synthase K00549,K22363 - 2.1.1.14,4.4.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 571.0
HKD2_k127_6443284_39 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 556.0
HKD2_k127_6443284_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1118.0
HKD2_k127_6443284_40 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 563.0
HKD2_k127_6443284_41 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 546.0
HKD2_k127_6443284_42 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 544.0
HKD2_k127_6443284_43 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 531.0
HKD2_k127_6443284_44 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 515.0
HKD2_k127_6443284_45 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009057 524.0
HKD2_k127_6443284_46 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009912 506.0
HKD2_k127_6443284_47 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 505.0
HKD2_k127_6443284_48 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 511.0
HKD2_k127_6443284_49 Trypsin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 515.0
HKD2_k127_6443284_5 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0 1054.0
HKD2_k127_6443284_50 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 497.0
HKD2_k127_6443284_51 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 480.0
HKD2_k127_6443284_52 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 478.0
HKD2_k127_6443284_53 Domain of unknown function (DUF4392) K22210 - 4.2.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 477.0
HKD2_k127_6443284_54 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005147 487.0
HKD2_k127_6443284_55 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 465.0
HKD2_k127_6443284_56 Adenylosuccinate lyase C-terminus K01756,K01857 - 4.3.2.2,5.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 468.0
HKD2_k127_6443284_57 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 456.0
HKD2_k127_6443284_58 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 449.0
HKD2_k127_6443284_59 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 464.0
HKD2_k127_6443284_6 amine dehydrogenase activity - - - 0.0 1048.0
HKD2_k127_6443284_60 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 447.0
HKD2_k127_6443284_61 carboxylic ester hydrolase activity K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 449.0
HKD2_k127_6443284_62 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 419.0
HKD2_k127_6443284_63 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 414.0
HKD2_k127_6443284_64 alcohol dehydrogenase K13954 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 431.0
HKD2_k127_6443284_65 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 406.0
HKD2_k127_6443284_66 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 431.0
HKD2_k127_6443284_67 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 408.0
HKD2_k127_6443284_68 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 400.0
HKD2_k127_6443284_69 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 398.0
HKD2_k127_6443284_7 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.0 1045.0
HKD2_k127_6443284_70 COG0564 Pseudouridylate synthases, 23S RNA-specific K06177 - 5.4.99.28,5.4.99.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 391.0
HKD2_k127_6443284_71 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 379.0
HKD2_k127_6443284_72 WHG domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 372.0
HKD2_k127_6443284_73 Pyroglutamyl peptidase K01304 - 3.4.19.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009138 363.0
HKD2_k127_6443284_74 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 375.0
HKD2_k127_6443284_75 (ABC) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 358.0
HKD2_k127_6443284_76 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 360.0
HKD2_k127_6443284_77 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 347.0
HKD2_k127_6443284_78 Glutathione S-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 333.0
HKD2_k127_6443284_79 IgA Peptidase M64 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 357.0
HKD2_k127_6443284_8 Amidohydrolase family - - - 0.0 1022.0
HKD2_k127_6443284_80 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 335.0
HKD2_k127_6443284_81 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 323.0
HKD2_k127_6443284_82 ABC transporter K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 322.0
HKD2_k127_6443284_83 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 323.0
HKD2_k127_6443284_84 isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 321.0
HKD2_k127_6443284_85 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 315.0
HKD2_k127_6443284_86 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 314.0
HKD2_k127_6443284_87 2-hydroxy-3-oxopropionate reductase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 306.0
HKD2_k127_6443284_88 COG1309 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 310.0
HKD2_k127_6443284_89 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 299.0
HKD2_k127_6443284_9 glutamine synthetase K01915 - 6.3.1.2 2.708e-301 925.0
HKD2_k127_6443284_90 Exopolysaccharide synthesis, ExoD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 298.0
HKD2_k127_6443284_91 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000941 298.0
HKD2_k127_6443284_92 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 284.0
HKD2_k127_6443284_93 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 296.0
HKD2_k127_6443284_95 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008998 279.0
HKD2_k127_6443284_96 SnoaL-like polyketide cyclase K07255 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006951 274.0
HKD2_k127_6443284_97 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000306 280.0
HKD2_k127_6443284_98 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002444 259.0
HKD2_k127_6443284_99 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001617 256.0
HKD2_k127_6446939_0 ATPase family associated with various cellular activities (AAA) K03924 - - 5.327e-195 613.0
HKD2_k127_6446939_1 poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 603.0
HKD2_k127_6446939_2 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 494.0
HKD2_k127_6446939_3 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 452.0
HKD2_k127_6446939_4 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000029 286.0
HKD2_k127_6455922_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0 1268.0
HKD2_k127_6455922_1 Adenylate cyclase - - - 1.163e-221 702.0
HKD2_k127_6455922_10 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000001867 83.0
HKD2_k127_6455922_11 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000009668 88.0
HKD2_k127_6455922_12 Protein of unknown function (DUF3592) - - - 0.0000001475 63.0
HKD2_k127_6455922_13 Alpha/beta hydrolase family K15357 - 3.5.1.106 0.00000521 59.0
HKD2_k127_6455922_2 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 336.0
HKD2_k127_6455922_3 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 319.0
HKD2_k127_6455922_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000007771 198.0
HKD2_k127_6455922_5 Amidohydrolase - - - 0.0000000000000000000000000000000000000007991 162.0
HKD2_k127_6455922_6 Major facilitator superfamily - - - 0.00000000000000000000000000000002203 137.0
HKD2_k127_6455922_7 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000001221 126.0
HKD2_k127_6455922_8 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 0.0000000000000000001231 95.0
HKD2_k127_6455922_9 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.00000000000000007766 96.0
HKD2_k127_6476011_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 7.169e-248 769.0
HKD2_k127_6476011_1 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005398 501.0
HKD2_k127_6476011_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004922 248.0
HKD2_k127_6476011_3 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000002895 207.0
HKD2_k127_6476011_4 - - - - 0.0000000000005727 72.0
HKD2_k127_6493856_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 9.685e-270 834.0
HKD2_k127_6493856_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 4.281e-235 734.0
HKD2_k127_6493856_2 COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 3.433e-212 663.0
HKD2_k127_6493856_3 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 7.104e-208 654.0
HKD2_k127_6493856_4 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 524.0
HKD2_k127_6493856_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 436.0
HKD2_k127_6493856_6 Glycosyltransferase like family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 365.0
HKD2_k127_6493856_7 Methyltransferase domain - - - 0.00000000000000000000000000001004 136.0
HKD2_k127_6493856_9 Cupin domain - - - 0.0001427 48.0
HKD2_k127_6495358_0 Cell division protein FtsI penicillin-binding protein 2 K05515 - 3.4.16.4 0.0 1099.0
HKD2_k127_6495358_1 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0 1096.0
HKD2_k127_6495358_10 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 500.0
HKD2_k127_6495358_11 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 480.0
HKD2_k127_6495358_12 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 471.0
HKD2_k127_6495358_13 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 456.0
HKD2_k127_6495358_14 Voltage-dependent anion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 438.0
HKD2_k127_6495358_15 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 415.0
HKD2_k127_6495358_16 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007317 336.0
HKD2_k127_6495358_18 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000715 327.0
HKD2_k127_6495358_19 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 328.0
HKD2_k127_6495358_2 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 1.01e-225 701.0
HKD2_k127_6495358_20 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 326.0
HKD2_k127_6495358_21 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 312.0
HKD2_k127_6495358_22 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008238 303.0
HKD2_k127_6495358_23 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 302.0
HKD2_k127_6495358_24 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001914 281.0
HKD2_k127_6495358_25 Acetolactate synthase small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004193 293.0
HKD2_k127_6495358_27 membrane K08988 - - 0.0000000000000000000000000000000000000000000000000000108 206.0
HKD2_k127_6495358_28 Urease accessory protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000003237 177.0
HKD2_k127_6495358_29 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000007978 169.0
HKD2_k127_6495358_3 Rod shape-determining protein MreB K03569 - - 2.576e-209 652.0
HKD2_k127_6495358_30 - - - - 0.0000000000000000000000000000000000000009615 153.0
HKD2_k127_6495358_31 - - - - 0.0000001912 55.0
HKD2_k127_6495358_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 2.786e-208 652.0
HKD2_k127_6495358_5 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 4.068e-208 649.0
HKD2_k127_6495358_6 HflC and HflK could encode or regulate a protease K04088 - - 9.822e-203 636.0
HKD2_k127_6495358_7 N-terminal domain of oxidoreductase K07119 - - 5.092e-196 618.0
HKD2_k127_6495358_8 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 589.0
HKD2_k127_6495358_9 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 509.0
HKD2_k127_6511112_0 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 1.318e-262 816.0
HKD2_k127_6511112_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 1.667e-228 710.0
HKD2_k127_6511112_10 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000915 261.0
HKD2_k127_6511112_11 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001297 235.0
HKD2_k127_6511112_12 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000000000000000000356 182.0
HKD2_k127_6511112_14 - - - - 0.00000000000000000000000000000000000833 147.0
HKD2_k127_6511112_15 Globin - - - 0.00000000000000000000000000002008 124.0
HKD2_k127_6511112_16 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000002077 125.0
HKD2_k127_6511112_17 TIR domain - - - 0.000000000000000001945 97.0
HKD2_k127_6511112_19 chlorophyll binding - - - 0.00000000000004987 83.0
HKD2_k127_6511112_2 Patatin phospholipase K07001 - - 5.377e-196 616.0
HKD2_k127_6511112_20 DNA ligase K01971 - 6.5.1.1 0.00000003371 58.0
HKD2_k127_6511112_21 - - - - 0.000001378 53.0
HKD2_k127_6511112_22 Transposase - - - 0.0005298 45.0
HKD2_k127_6511112_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 514.0
HKD2_k127_6511112_4 taurine catabolism dioxygenase K03119,K22303 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 507.0
HKD2_k127_6511112_5 Acetoacetate decarboxylase (ADC) K01574 - 4.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 484.0
HKD2_k127_6511112_6 KR domain K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 455.0
HKD2_k127_6511112_7 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 421.0
HKD2_k127_6511112_8 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 324.0
HKD2_k127_6511112_9 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 293.0
HKD2_k127_6562205_0 ImcF-related N-terminal domain K11891 - - 0.0 1771.0
HKD2_k127_6562205_1 COG0542 ATPases with chaperone activity ATP-binding subunit K11907 - - 0.0 1432.0
HKD2_k127_6562205_10 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 4.093e-237 744.0
HKD2_k127_6562205_11 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 9.098e-232 720.0
HKD2_k127_6562205_12 Type VI secretion system protein DotU K11892 - - 2.759e-222 696.0
HKD2_k127_6562205_13 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008063 553.0
HKD2_k127_6562205_14 conserved protein, contains FHA domain K11894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 557.0
HKD2_k127_6562205_15 ImpA, N-terminal, type VI secretion system K11902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 492.0
HKD2_k127_6562205_16 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 471.0
HKD2_k127_6562205_17 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 458.0
HKD2_k127_6562205_18 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 455.0
HKD2_k127_6562205_19 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 427.0
HKD2_k127_6562205_2 Type VI secretion system, TssF K11896 - - 0.0 1096.0
HKD2_k127_6562205_20 Protein of avirulence locus involved in temperature-dependent protein secretion K11898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 412.0
HKD2_k127_6562205_21 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 405.0
HKD2_k127_6562205_22 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 406.0
HKD2_k127_6562205_23 Protein phosphatase 2C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 384.0
HKD2_k127_6562205_24 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 373.0
HKD2_k127_6562205_25 Amidohydrolase K07046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 370.0
HKD2_k127_6562205_26 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 329.0
HKD2_k127_6562205_27 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 332.0
HKD2_k127_6562205_28 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008519 324.0
HKD2_k127_6562205_29 Uncharacterized protein conserved in bacteria (DUF2094) K11890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 293.0
HKD2_k127_6562205_3 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 4.539e-301 925.0
HKD2_k127_6562205_30 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 291.0
HKD2_k127_6562205_31 Type VI secretion, TssG K11895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 299.0
HKD2_k127_6562205_32 Type VI secretion system, VipA, VC_A0107 or Hcp2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 282.0
HKD2_k127_6562205_33 anti-sigma factor antagonist activity K11897 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000098 266.0
HKD2_k127_6562205_34 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001115 279.0
HKD2_k127_6562205_35 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002226 289.0
HKD2_k127_6562205_36 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003918 260.0
HKD2_k127_6562205_37 Type VI secretion system effector, Hcp - - - 0.0000000000000000000000000000000000000000000000000000000000000001114 235.0
HKD2_k127_6562205_38 Glycine cleavage H-protein K02437 - - 0.00000000000000000000000000000000000000000000000000000005351 199.0
HKD2_k127_6562205_4 Phage late control gene D protein (GPD) - - - 8.96e-272 848.0
HKD2_k127_6562205_40 ATPase activity - - - 0.000000000000000000000000000000000000000000000002795 179.0
HKD2_k127_6562205_41 Type VI secretion K11906 - - 0.0000000000000000000000000000000000000000000001569 177.0
HKD2_k127_6562205_42 - - - - 0.000000000000000000000000000000000000000000001927 175.0
HKD2_k127_6562205_43 - - - - 0.0000000000000000000000000000000000000000000059 172.0
HKD2_k127_6562205_44 Conserved hypothetical protein 698 - - - 0.0000000000000000000000000000000000000000002035 164.0
HKD2_k127_6562205_45 PAAR motif - - - 0.0000000000000000000000000000000000000000009014 163.0
HKD2_k127_6562205_46 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000004024 146.0
HKD2_k127_6562205_47 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000449 117.0
HKD2_k127_6562205_5 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 8.352e-267 828.0
HKD2_k127_6562205_50 - - - - 0.000000000000000181 81.0
HKD2_k127_6562205_51 FAD dependent oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000003546 79.0
HKD2_k127_6562205_6 Protein conserved in bacteria K11893 - - 1.962e-266 831.0
HKD2_k127_6562205_7 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 3.548e-258 813.0
HKD2_k127_6562205_8 serine threonine protein kinase K08282 - 2.7.11.1 7.965e-251 792.0
HKD2_k127_6562205_9 Predicted methyltransferase regulatory domain - - - 1.18e-246 769.0
HKD2_k127_6567900_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.0 1363.0
HKD2_k127_6567900_1 Hydantoinase B/oxoprolinase - - - 0.0 1069.0
HKD2_k127_6567900_10 oxidase, subunit K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 596.0
HKD2_k127_6567900_11 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 579.0
HKD2_k127_6567900_12 Nitronate monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 575.0
HKD2_k127_6567900_13 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 548.0
HKD2_k127_6567900_14 Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 522.0
HKD2_k127_6567900_15 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 485.0
HKD2_k127_6567900_16 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 477.0
HKD2_k127_6567900_17 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 473.0
HKD2_k127_6567900_18 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 434.0
HKD2_k127_6567900_19 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 398.0
HKD2_k127_6567900_2 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 7.003e-318 979.0
HKD2_k127_6567900_20 COG0861 Membrane protein TerC, possibly involved in tellurium resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 351.0
HKD2_k127_6567900_21 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 341.0
HKD2_k127_6567900_22 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 319.0
HKD2_k127_6567900_23 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 293.0
HKD2_k127_6567900_24 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 297.0
HKD2_k127_6567900_25 formyl-CoA transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002037 292.0
HKD2_k127_6567900_26 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001165 263.0
HKD2_k127_6567900_28 - - - - 0.000000000000000000000000000000000000000000000000000000000008752 228.0
HKD2_k127_6567900_29 Involved in biosynthesis of extracellular polysaccharides - - - 0.000000000000000000000000000000000000000000000000001085 186.0
HKD2_k127_6567900_3 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 9.301e-255 791.0
HKD2_k127_6567900_31 formyl-CoA transferase activity - - - 0.0000000000000000000000000000000000000000000007921 181.0
HKD2_k127_6567900_32 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000000000000000000000002725 139.0
HKD2_k127_6567900_33 - - - - 0.00000000000000000000000000000008163 131.0
HKD2_k127_6567900_4 Luciferase-like monooxygenase - - - 1.41e-249 773.0
HKD2_k127_6567900_5 acetyl-coa acetyltransferase - - - 2.977e-244 756.0
HKD2_k127_6567900_6 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 1.339e-238 738.0
HKD2_k127_6567900_7 Psort location Cytoplasmic, score 7.50 - - - 2.13e-229 730.0
HKD2_k127_6567900_8 Major Facilitator - - - 3.571e-206 659.0
HKD2_k127_6567900_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007904 599.0
HKD2_k127_6582738_0 acid transport system permease K09970 - - 1.277e-223 696.0
HKD2_k127_6582738_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 - 4.2.1.46,4.2.1.76 4.704e-212 662.0
HKD2_k127_6582738_10 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 468.0
HKD2_k127_6582738_11 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 403.0
HKD2_k127_6582738_12 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 388.0
HKD2_k127_6582738_13 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 372.0
HKD2_k127_6582738_14 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 320.0
HKD2_k127_6582738_15 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 312.0
HKD2_k127_6582738_16 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000002934 216.0
HKD2_k127_6582738_17 WxcM-like, C-terminal - - - 0.00000000000000000000000000000000000000000000000000000001372 215.0
HKD2_k127_6582738_18 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000715 186.0
HKD2_k127_6582738_2 Belongs to the DegT DnrJ EryC1 family - - - 2.416e-202 635.0
HKD2_k127_6582738_20 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000001549 110.0
HKD2_k127_6582738_3 2-nitropropane dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 599.0
HKD2_k127_6582738_4 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 567.0
HKD2_k127_6582738_5 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 567.0
HKD2_k127_6582738_6 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 501.0
HKD2_k127_6582738_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 492.0
HKD2_k127_6582738_8 acid transport K09972 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 479.0
HKD2_k127_6582738_9 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 481.0
HKD2_k127_6597933_0 Binding-protein-dependent transport system inner membrane component K02050 - - 2.195e-296 917.0
HKD2_k127_6597933_1 C-terminal AAA-associated domain K02049 - - 1.73e-240 747.0
HKD2_k127_6597933_10 Domain of unknown function (DUF4347) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002837 279.0
HKD2_k127_6597933_11 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006033 275.0
HKD2_k127_6597933_12 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001675 246.0
HKD2_k127_6597933_13 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001956 246.0
HKD2_k127_6597933_14 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000001047 153.0
HKD2_k127_6597933_15 helix_turn_helix, mercury resistance K08365 - - 0.000000000000000000000000000000000002206 149.0
HKD2_k127_6597933_16 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000002256 137.0
HKD2_k127_6597933_17 Pfam Amidohydrolase - - - 0.00000000000000000000000000001473 123.0
HKD2_k127_6597933_18 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000118 120.0
HKD2_k127_6597933_19 AntiSigma factor - - - 0.00000000000000000000001233 110.0
HKD2_k127_6597933_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 3.402e-239 746.0
HKD2_k127_6597933_20 Plasmid stabilization system - - - 0.000000000000000000003429 98.0
HKD2_k127_6597933_21 - - - - 0.000000000000000001146 91.0
HKD2_k127_6597933_22 PFAM CopG domain protein DNA-binding domain protein - - - 0.00000000000002671 77.0
HKD2_k127_6597933_23 Transposase, Mutator family K07493 - - 0.00000000003562 71.0
HKD2_k127_6597933_24 MerT mercuric transport protein - - - 0.0000000007761 65.0
HKD2_k127_6597933_3 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 3.956e-211 678.0
HKD2_k127_6597933_4 40-residue yvtn family beta-propeller repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 596.0
HKD2_k127_6597933_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 567.0
HKD2_k127_6597933_6 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 581.0
HKD2_k127_6597933_7 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 531.0
HKD2_k127_6597933_8 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009582 282.0
HKD2_k127_6597933_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000002219 257.0
HKD2_k127_6641121_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1498.0
HKD2_k127_6641121_1 Heavy-metal-associated domain K01533 - 3.6.3.4 0.0 1100.0
HKD2_k127_6641121_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 582.0
HKD2_k127_6641121_3 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006936 536.0
HKD2_k127_6641121_4 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 529.0
HKD2_k127_6641121_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 475.0
HKD2_k127_6641121_6 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 437.0
HKD2_k127_6641121_7 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 363.0
HKD2_k127_6641121_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 359.0
HKD2_k127_6641121_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007079 284.0
HKD2_k127_6683633_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 9.974e-316 970.0
HKD2_k127_6683633_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.524e-226 723.0
HKD2_k127_6683633_2 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 376.0
HKD2_k127_6683633_3 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 368.0
HKD2_k127_6683633_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000002899 140.0
HKD2_k127_6685623_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1344.0
HKD2_k127_6685623_1 COG0768 Cell division protein FtsI penicillin-binding protein 2 K03587 - 3.4.16.4 0.0 1006.0
HKD2_k127_6685623_10 Belongs to the SEDS family K03588 - - 5.532e-215 671.0
HKD2_k127_6685623_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.308e-205 643.0
HKD2_k127_6685623_12 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 1.737e-201 647.0
HKD2_k127_6685623_13 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 585.0
HKD2_k127_6685623_14 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 555.0
HKD2_k127_6685623_15 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 560.0
HKD2_k127_6685623_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 543.0
HKD2_k127_6685623_17 cytochrome c oxidase K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 530.0
HKD2_k127_6685623_18 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 509.0
HKD2_k127_6685623_19 Catechol dioxygenase N terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 504.0
HKD2_k127_6685623_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 7.94e-286 900.0
HKD2_k127_6685623_20 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 511.0
HKD2_k127_6685623_21 Aspartyl/Asparaginyl beta-hydroxylase K12979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 480.0
HKD2_k127_6685623_22 Cell division protein FtsQ K03589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 478.0
HKD2_k127_6685623_23 SURF1-like protein K14998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 439.0
HKD2_k127_6685623_24 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 396.0
HKD2_k127_6685623_25 Tellurite resistance protein TerB K05801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 379.0
HKD2_k127_6685623_26 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 383.0
HKD2_k127_6685623_27 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 376.0
HKD2_k127_6685623_28 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 383.0
HKD2_k127_6685623_29 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 300.0
HKD2_k127_6685623_3 Threonine synthase K01733 - 4.2.3.1 3.444e-269 837.0
HKD2_k127_6685623_30 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 293.0
HKD2_k127_6685623_31 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000000000000000000000000000000001108 217.0
HKD2_k127_6685623_32 COG3023 Negative regulator of beta-lactamase expression K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000001384 226.0
HKD2_k127_6685623_33 Protein of unknown function (DUF1272) K09984 - - 0.00000000000000000000000000000000000000000000000001122 179.0
HKD2_k127_6685623_35 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000007173 75.0
HKD2_k127_6685623_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 4.187e-257 797.0
HKD2_k127_6685623_5 Belongs to the peptidase M16 family - - - 1.891e-252 781.0
HKD2_k127_6685623_6 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 2.279e-244 761.0
HKD2_k127_6685623_7 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 4.219e-241 754.0
HKD2_k127_6685623_8 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 3.247e-239 747.0
HKD2_k127_6685623_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 5.082e-220 687.0
HKD2_k127_6722322_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0 1041.0
HKD2_k127_6722322_1 Belongs to the peptidase S16 family - - - 1.046e-277 879.0
HKD2_k127_6722322_10 Sugar (and other) transporter K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 565.0
HKD2_k127_6722322_11 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 558.0
HKD2_k127_6722322_12 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 492.0
HKD2_k127_6722322_13 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 440.0
HKD2_k127_6722322_14 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 383.0
HKD2_k127_6722322_15 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 362.0
HKD2_k127_6722322_16 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 353.0
HKD2_k127_6722322_17 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 339.0
HKD2_k127_6722322_18 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008517 286.0
HKD2_k127_6722322_19 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002848 283.0
HKD2_k127_6722322_2 COG4618 ABC-type protease lipase transport system, ATPase and permease components K16299 - - 6.54e-269 860.0
HKD2_k127_6722322_20 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003651 265.0
HKD2_k127_6722322_21 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005452 274.0
HKD2_k127_6722322_22 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001267 261.0
HKD2_k127_6722322_23 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000000000000000000000000000006955 193.0
HKD2_k127_6722322_24 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000006122 195.0
HKD2_k127_6722322_25 - - - - 0.000000000000000000002888 111.0
HKD2_k127_6722322_26 Phosphopantetheine attachment site - - - 0.000000000002125 80.0
HKD2_k127_6722322_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 8.851e-269 835.0
HKD2_k127_6722322_4 Aminotransferase class-III - - - 9.1e-265 818.0
HKD2_k127_6722322_5 FAD dependent oxidoreductase - - - 1.465e-213 666.0
HKD2_k127_6722322_6 Rieske [2Fe-2S] domain - - - 1.513e-208 683.0
HKD2_k127_6722322_7 - - - - 5.368e-204 675.0
HKD2_k127_6722322_8 COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family K18459 - 3.5.3.17 3.264e-202 631.0
HKD2_k127_6722322_9 COG0845 Membrane-fusion protein K16300 - - 2.174e-197 651.0
HKD2_k127_6725850_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 2106.0
HKD2_k127_6725850_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1833.0
HKD2_k127_6725850_10 Zn-dependent protease, contains TPR repeats - - - 3.42e-221 693.0
HKD2_k127_6725850_11 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 1.81e-219 683.0
HKD2_k127_6725850_12 Aminotransferase - - - 2.167e-217 677.0
HKD2_k127_6725850_13 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 593.0
HKD2_k127_6725850_14 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 573.0
HKD2_k127_6725850_15 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 567.0
HKD2_k127_6725850_16 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 572.0
HKD2_k127_6725850_17 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 551.0
HKD2_k127_6725850_18 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 525.0
HKD2_k127_6725850_19 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009118 525.0
HKD2_k127_6725850_2 Belongs to the ClpA ClpB family K03694 - - 0.0 1454.0
HKD2_k127_6725850_20 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 499.0
HKD2_k127_6725850_21 malonyl CoA-acyl carrier protein transacylase K00645,K15327 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 484.0
HKD2_k127_6725850_22 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 432.0
HKD2_k127_6725850_23 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 399.0
HKD2_k127_6725850_25 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 380.0
HKD2_k127_6725850_26 Lysozyme inhibitor LprI - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 389.0
HKD2_k127_6725850_27 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 362.0
HKD2_k127_6725850_28 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 354.0
HKD2_k127_6725850_29 PFAM heat shock protein DnaJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009468 350.0
HKD2_k127_6725850_3 phosphomannomutase K01840 - 5.4.2.8 1.179e-276 854.0
HKD2_k127_6725850_30 Bacterial transcriptional repressor C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 284.0
HKD2_k127_6725850_31 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000591 271.0
HKD2_k127_6725850_32 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003409 263.0
HKD2_k127_6725850_33 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000007615 225.0
HKD2_k127_6725850_34 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000177 227.0
HKD2_k127_6725850_35 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000000000000001857 218.0
HKD2_k127_6725850_36 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000001104 213.0
HKD2_k127_6725850_37 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.0000000000000000000000000000000000000000000000000000000006451 204.0
HKD2_k127_6725850_38 - - - - 0.00000000000000000000000000000000000000000000000000000004192 198.0
HKD2_k127_6725850_39 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000001917 171.0
HKD2_k127_6725850_4 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 2.092e-260 816.0
HKD2_k127_6725850_40 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000000000878 148.0
HKD2_k127_6725850_41 - - - - 0.000000000000000000000000000000003685 130.0
HKD2_k127_6725850_43 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.00000000000000000002953 96.0
HKD2_k127_6725850_44 NADH ubiquinone oxidoreductase subunit NDUFA12 K00356 - 1.6.99.3 0.0000000000000000002699 93.0
HKD2_k127_6725850_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.756e-258 799.0
HKD2_k127_6725850_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.704e-252 783.0
HKD2_k127_6725850_7 Peptidogalycan biosysnthesis/recognition K09919 - - 2.026e-243 753.0
HKD2_k127_6725850_8 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 4.985e-238 739.0
HKD2_k127_6725850_9 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.3e-237 741.0
HKD2_k127_6734992_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0 1092.0
HKD2_k127_6734992_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.298e-319 991.0
HKD2_k127_6734992_10 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001427 274.0
HKD2_k127_6734992_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001354 252.0
HKD2_k127_6734992_12 FR47-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001933 252.0
HKD2_k127_6734992_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000001004 223.0
HKD2_k127_6734992_14 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000002274 178.0
HKD2_k127_6734992_15 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000001256 171.0
HKD2_k127_6734992_16 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000008658 168.0
HKD2_k127_6734992_17 Acetyltransferase (GNAT) domain - - - 0.0000000005937 68.0
HKD2_k127_6734992_18 acetyltransferase - - - 0.000103 53.0
HKD2_k127_6734992_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 1.233e-283 877.0
HKD2_k127_6734992_3 Uncharacterized protein conserved in bacteria (DUF2272) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 389.0
HKD2_k127_6734992_4 Uncharacterized protein conserved in bacteria (DUF2272) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 372.0
HKD2_k127_6734992_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 351.0
HKD2_k127_6734992_6 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 319.0
HKD2_k127_6734992_7 Putative stress-induced transcription regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 308.0
HKD2_k127_6734992_9 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002765 287.0
HKD2_k127_6760771_0 COG0591 Na proline symporter - - - 0.0 1815.0
HKD2_k127_6760771_1 Methionine synthase K00548 - 2.1.1.13 0.0 1590.0
HKD2_k127_6760771_10 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 358.0
HKD2_k127_6760771_11 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 359.0
HKD2_k127_6760771_12 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 328.0
HKD2_k127_6760771_13 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 329.0
HKD2_k127_6760771_14 intermembrane phospholipid transfer K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001197 265.0
HKD2_k127_6760771_15 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001729 265.0
HKD2_k127_6760771_17 Fusaric acid resistance protein-like - - - 0.000000000000000000000000000000000000000001246 175.0
HKD2_k127_6760771_2 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 0.0 1037.0
HKD2_k127_6760771_3 Sugar (and other) transporter - - - 2.847e-247 781.0
HKD2_k127_6760771_4 Homocysteine S-methyltransferase K00548 - 2.1.1.13 1.959e-202 639.0
HKD2_k127_6760771_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 601.0
HKD2_k127_6760771_6 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 529.0
HKD2_k127_6760771_7 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 487.0
HKD2_k127_6760771_8 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 434.0
HKD2_k127_6760771_9 MlaA lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 400.0
HKD2_k127_6761685_0 urea carboxylase K01941 - 6.3.4.6 0.0 2172.0
HKD2_k127_6761685_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01457 - 3.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 533.0
HKD2_k127_6761685_2 urea carboxylase-associated protein 1 K09967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009091 430.0
HKD2_k127_6761685_3 TIGRFAM Urea carboxylase-associated protein 2 K09967 - - 0.00000000000000000000001698 99.0
HKD2_k127_6781443_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1685.0
HKD2_k127_6781443_1 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 617.0
HKD2_k127_6781443_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 499.0
HKD2_k127_6781443_3 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 312.0
HKD2_k127_6781443_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 300.0
HKD2_k127_6781443_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001379 228.0
HKD2_k127_6781443_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001231 230.0
HKD2_k127_6781443_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000001581 175.0
HKD2_k127_6781443_8 Transposase DDE domain - - - 0.000000000000000000000002122 102.0
HKD2_k127_6781443_9 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit K02433 - 6.3.5.6,6.3.5.7 0.000000005835 61.0
HKD2_k127_6784175_0 Fic/DOC family - - - 2.081e-255 796.0
HKD2_k127_6784175_1 P-aminobenzoate N-oxygenase AurF - - - 4.462e-222 689.0
HKD2_k127_6784175_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 326.0
HKD2_k127_6784175_12 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003037 278.0
HKD2_k127_6784175_13 Group II intron, maturase-specific domain K00986,K15342 - 2.7.7.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000002489 276.0
HKD2_k127_6784175_14 PFAM transposase mutator type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009824 244.0
HKD2_k127_6784175_15 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000002244 226.0
HKD2_k127_6784175_16 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000000000000002156 216.0
HKD2_k127_6784175_17 Toprim domain - - - 0.0000000000000000000000000000000000000000004858 168.0
HKD2_k127_6784175_18 DNA integration - - - 0.0000000000000000000000000000000000000474 154.0
HKD2_k127_6784175_19 YGGT family K02221 - - 0.0000000000000000000000000000000002082 133.0
HKD2_k127_6784175_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 522.0
HKD2_k127_6784175_20 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000006045 147.0
HKD2_k127_6784175_21 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000000007033 109.0
HKD2_k127_6784175_23 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000001301 96.0
HKD2_k127_6784175_24 phosphatase activity K05967 - - 0.0000000005909 65.0
HKD2_k127_6784175_25 SOS response associated peptidase (SRAP) - - - 0.000000037 61.0
HKD2_k127_6784175_28 SOS response associated peptidase (SRAP) - - - 0.000111 51.0
HKD2_k127_6784175_3 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 492.0
HKD2_k127_6784175_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 484.0
HKD2_k127_6784175_5 Toprim domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 411.0
HKD2_k127_6784175_6 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 419.0
HKD2_k127_6784175_7 Zinc-uptake complex component A periplasmic K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 416.0
HKD2_k127_6784175_8 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 363.0
HKD2_k127_681113_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 582.0
HKD2_k127_681113_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 485.0
HKD2_k127_681113_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 487.0
HKD2_k127_681113_3 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000004201 221.0
HKD2_k127_681113_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000001676 169.0
HKD2_k127_681113_5 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000001719 173.0
HKD2_k127_681113_6 hydroperoxide reductase activity - - - 0.000000000000000000000000000000000000000003275 156.0
HKD2_k127_681113_7 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000001171 149.0
HKD2_k127_681113_8 - - - - 0.00000000000003564 78.0
HKD2_k127_6840347_0 Domain of unknown function (DUF4175) - - - 0.0 1439.0
HKD2_k127_6840347_1 argininosuccinate lyase K01755 - 4.3.2.1 2.74e-269 833.0
HKD2_k127_6840347_10 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 342.0
HKD2_k127_6840347_11 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 307.0
HKD2_k127_6840347_12 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 272.0
HKD2_k127_6840347_13 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003022 263.0
HKD2_k127_6840347_14 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004399 262.0
HKD2_k127_6840347_15 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003108 239.0
HKD2_k127_6840347_16 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000001174 214.0
HKD2_k127_6840347_17 - - - - 0.00000000000000000000000000000000000000000000000000004069 192.0
HKD2_k127_6840347_18 Sulfatase K01130 - 3.1.6.1 0.00000000000000000000000000122 126.0
HKD2_k127_6840347_2 amine oxidase K00274 - 1.4.3.4 4.957e-242 762.0
HKD2_k127_6840347_20 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000001105 72.0
HKD2_k127_6840347_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 6.031e-230 745.0
HKD2_k127_6840347_4 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 555.0
HKD2_k127_6840347_5 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 554.0
HKD2_k127_6840347_6 electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 537.0
HKD2_k127_6840347_7 ABC transporter substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 495.0
HKD2_k127_6840347_8 Electron transfer flavoprotein, beta subunit K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 457.0
HKD2_k127_6840347_9 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 387.0
HKD2_k127_6853207_0 ABC-type dipeptide transport system periplasmic component K02035 - - 2.872e-280 871.0
HKD2_k127_6853207_1 Gamma-glutamyltranspeptidase - - - 5.111e-259 807.0
HKD2_k127_6853207_10 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000002656 93.0
HKD2_k127_6853207_12 PFAM CBS domain containing protein - - - 0.000000000000001391 81.0
HKD2_k127_6853207_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 3.19e-213 667.0
HKD2_k127_6853207_3 COG0526, thiol-disulfide isomerase and thioredoxins - - - 2.952e-207 647.0
HKD2_k127_6853207_4 Luciferase-like monooxygenase K04091 - 1.14.14.5 5.945e-202 663.0
HKD2_k127_6853207_5 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 591.0
HKD2_k127_6853207_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 541.0
HKD2_k127_6853207_7 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 500.0
HKD2_k127_6853207_8 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 430.0
HKD2_k127_6853207_9 Chitinase class I K03791 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 318.0
HKD2_k127_6884560_0 A circularly permuted ATPgrasp - - - 3.578e-267 848.0
HKD2_k127_6884560_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 574.0
HKD2_k127_6884560_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 471.0
HKD2_k127_6884560_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 443.0
HKD2_k127_6884560_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 304.0
HKD2_k127_6884560_5 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000002384 237.0
HKD2_k127_6884560_6 type II secretion system protein E K02283,K20527 - - 0.000000000000000009224 96.0
HKD2_k127_7003704_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 2.263e-221 706.0
HKD2_k127_7003704_1 PFAM AMP-dependent synthetase and ligase K02182 - 6.2.1.48 1.162e-220 699.0
HKD2_k127_7003704_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000001555 173.0
HKD2_k127_7003704_11 - - - - 0.000000000000000000000000000000000000000003909 165.0
HKD2_k127_7003704_12 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000004085 158.0
HKD2_k127_7003704_13 - - - - 0.0000000000000000000000001114 117.0
HKD2_k127_7003704_14 SnoaL-like domain - - - 0.00000000000000000001278 98.0
HKD2_k127_7003704_15 - - - - 0.000000000008959 68.0
HKD2_k127_7003704_2 P-aminobenzoate N-oxygenase AurF - - - 1.646e-207 648.0
HKD2_k127_7003704_3 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 9.453e-199 638.0
HKD2_k127_7003704_4 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 473.0
HKD2_k127_7003704_5 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 464.0
HKD2_k127_7003704_6 RibD C-terminal domain K00082 - 1.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 349.0
HKD2_k127_7003704_7 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001323 276.0
HKD2_k127_7003704_8 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001422 259.0
HKD2_k127_7003704_9 DoxX-like family K15977 - - 0.00000000000000000000000000000000000000000000000001002 188.0
HKD2_k127_705677_0 ubiE/COQ5 methyltransferase family - - - 1.705e-257 795.0
HKD2_k127_705677_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.067e-254 788.0
HKD2_k127_705677_10 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 558.0
HKD2_k127_705677_11 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 543.0
HKD2_k127_705677_12 Belongs to the HypD family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006293 528.0
HKD2_k127_705677_13 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 546.0
HKD2_k127_705677_14 PFAM Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 476.0
HKD2_k127_705677_15 AIR synthase related protein, N-terminal domain K04655 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 441.0
HKD2_k127_705677_16 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 376.0
HKD2_k127_705677_17 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 377.0
HKD2_k127_705677_18 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 337.0
HKD2_k127_705677_19 SpoU rRNA Methylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 327.0
HKD2_k127_705677_2 signal transduction histidine kinase K07636 - 2.7.13.3 3.257e-239 745.0
HKD2_k127_705677_20 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 322.0
HKD2_k127_705677_21 Sigma-70 region 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 297.0
HKD2_k127_705677_22 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000004876 236.0
HKD2_k127_705677_23 Group II intron, maturase-specific domain - - - 0.0000000000000000000000000000000000000000000000000000000000004881 216.0
HKD2_k127_705677_24 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.000000000000000000000000000000000000000000000000000000000001494 217.0
HKD2_k127_705677_25 Hydrogenase maturation protease - - - 0.0000000000000000000000000000000000000000006843 169.0
HKD2_k127_705677_26 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000002966 158.0
HKD2_k127_705677_27 pathogenesis - - - 0.000000000000000000000003871 108.0
HKD2_k127_705677_28 Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - 0.000000000000000000002129 98.0
HKD2_k127_705677_29 transposition K07497,K09958 - - 0.0000000000000000001223 90.0
HKD2_k127_705677_3 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564 - 5.796e-234 750.0
HKD2_k127_705677_30 YCII-related domain - - - 0.0000000000000000002817 92.0
HKD2_k127_705677_31 Protein of unknown function (DUF3141) - - - 0.000000000000001682 77.0
HKD2_k127_705677_32 HNH endonuclease - - - 0.000000000000002996 82.0
HKD2_k127_705677_34 carbon dioxide binding K04653 - - 0.000000000001982 75.0
HKD2_k127_705677_35 Autotransporter beta-domain - - - 0.00000000003233 65.0
HKD2_k127_705677_36 YCII-related domain - - - 0.00003051 52.0
HKD2_k127_705677_37 YCII-related domain - - - 0.00005899 51.0
HKD2_k127_705677_4 Nickel-dependent hydrogenase K00436 - 1.12.1.2 6.428e-230 718.0
HKD2_k127_705677_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 1.326e-224 698.0
HKD2_k127_705677_6 Radical SAM K06937 - - 3.409e-211 666.0
HKD2_k127_705677_7 Major Facilitator Superfamily - - - 3.69e-205 646.0
HKD2_k127_705677_8 Thiolase, C-terminal domain K00626,K00632 - 2.3.1.16,2.3.1.9 1.243e-204 661.0
HKD2_k127_705677_9 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 572.0
HKD2_k127_7071102_0 Hydantoinase/oxoprolinase - - - 0.0 1171.0
HKD2_k127_7071102_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1156.0
HKD2_k127_7071102_10 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 428.0
HKD2_k127_7071102_11 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 402.0
HKD2_k127_7071102_12 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 396.0
HKD2_k127_7071102_13 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 380.0
HKD2_k127_7071102_14 Ornithine cyclodeaminase/mu-crystallin family K01750,K19743 - 1.5.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 352.0
HKD2_k127_7071102_15 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000000000000000001397 196.0
HKD2_k127_7071102_16 Lipopolysaccharide assembly protein A domain - - - 0.00000000000000000000000000000000000000000000000001413 188.0
HKD2_k127_7071102_17 - - - - 0.0000000000000000000000000000000000000000000004615 175.0
HKD2_k127_7071102_18 DNA-binding transcription factor activity K06075 - - 0.000000000000000000000000000000000000000000001403 170.0
HKD2_k127_7071102_19 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000391 105.0
HKD2_k127_7071102_2 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.0 1054.0
HKD2_k127_7071102_3 COG1180 Pyruvate-formate lyase-activating enzyme - - - 1.709e-293 903.0
HKD2_k127_7071102_4 L-carnitine dehydratase bile acid-inducible protein - - - 1.667e-242 760.0
HKD2_k127_7071102_5 Receptor family ligand binding region K01999 - - 3.351e-235 730.0
HKD2_k127_7071102_6 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 6.244e-225 700.0
HKD2_k127_7071102_7 Domain of unknown function DUF108 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 444.0
HKD2_k127_7071102_8 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 434.0
HKD2_k127_7071102_9 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 437.0
HKD2_k127_7170709_0 COG0480 Translation elongation factors (GTPases) K02355 - - 5.618e-268 830.0
HKD2_k127_7170709_1 Aminotransferase K00812 - 2.6.1.1 1.062e-225 705.0
HKD2_k127_7170709_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 526.0
HKD2_k127_7170709_3 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 501.0
HKD2_k127_7170709_4 COG3209 Rhs family protein - - - 0.000000000007478 72.0
HKD2_k127_7217068_0 Enoyl-CoA hydratase/isomerase - - - 0.0 1028.0
HKD2_k127_7217068_1 benzoyl-CoA oxygenase - - - 3.107e-288 888.0
HKD2_k127_7217068_10 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000006002 181.0
HKD2_k127_7217068_11 Protein of unknown function (DUF2971) - - - 0.000000000000000000000000004946 123.0
HKD2_k127_7217068_13 conserved protein, contains double-stranded beta-helix domain - - - 0.0009028 47.0
HKD2_k127_7217068_2 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.318e-270 845.0
HKD2_k127_7217068_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.868e-236 739.0
HKD2_k127_7217068_4 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 1.067e-211 663.0
HKD2_k127_7217068_5 Adenylate cyclase K01768 - 4.6.1.1 2.545e-211 667.0
HKD2_k127_7217068_6 Adenylate cyclase K01768 - 4.6.1.1 1.273e-198 650.0
HKD2_k127_7217068_7 Transglutaminase - - - 2.551e-195 632.0
HKD2_k127_7217068_8 HIUase/Transthyretin family K13485 - 4.1.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 484.0
HKD2_k127_7217068_9 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000002002 226.0
HKD2_k127_721870_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1375.0
HKD2_k127_721870_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 1.125e-211 674.0
HKD2_k127_721870_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000000000000000000000000000006959 238.0
HKD2_k127_721870_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000008718 206.0
HKD2_k127_721870_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 570.0
HKD2_k127_721870_3 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 541.0
HKD2_k127_721870_4 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 533.0
HKD2_k127_721870_5 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 529.0
HKD2_k127_721870_6 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 451.0
HKD2_k127_721870_7 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 426.0
HKD2_k127_721870_8 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 421.0
HKD2_k127_721870_9 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 307.0
HKD2_k127_7259061_0 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 2.412e-294 913.0
HKD2_k127_7259061_1 Binding-protein-dependent transport system inner membrane component K02011 - - 6.866e-262 818.0
HKD2_k127_7259061_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004716 453.0
HKD2_k127_7259061_11 TOBE domain K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 454.0
HKD2_k127_7259061_12 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 415.0
HKD2_k127_7259061_13 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 310.0
HKD2_k127_7259061_14 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 307.0
HKD2_k127_7259061_15 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000006179 238.0
HKD2_k127_7259061_16 helix_turn_helix isocitrate lyase regulation K02624,K20539 - - 0.0000000000000000000000000000000000000000000000000000000001866 212.0
HKD2_k127_7259061_17 Acetyltransferase (GNAT) domain K22479 - - 0.000000000000000000000000000000000000000000000000002732 193.0
HKD2_k127_7259061_18 PFAM PilT protein domain protein - - - 0.00000000000000000000000000000000000000000003427 185.0
HKD2_k127_7259061_19 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000000008249 143.0
HKD2_k127_7259061_2 Psort location Cytoplasmic, score 7.50 - - - 1.113e-255 790.0
HKD2_k127_7259061_20 SpoVT / AbrB like domain - - - 0.0000000000000000000003046 97.0
HKD2_k127_7259061_21 Transposase IS200 like K07491 - - 0.0000000000000000000003664 100.0
HKD2_k127_7259061_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 4.367e-218 681.0
HKD2_k127_7259061_4 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007334 524.0
HKD2_k127_7259061_5 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 511.0
HKD2_k127_7259061_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 468.0
HKD2_k127_7259061_7 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 479.0
HKD2_k127_7259061_8 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 474.0
HKD2_k127_7259061_9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 475.0
HKD2_k127_7262563_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.0 1066.0
HKD2_k127_7262563_1 Glycosyltransferase family 28 C-terminal domain - - - 0.0 1033.0
HKD2_k127_7262563_10 Efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 497.0
HKD2_k127_7262563_11 Oxidoreductase NAD-binding domain K00380,K02641,K14338 - 1.14.14.1,1.18.1.2,1.6.2.4,1.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 503.0
HKD2_k127_7262563_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 454.0
HKD2_k127_7262563_13 Proline racemase K12658 - 5.1.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 451.0
HKD2_k127_7262563_14 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007907 448.0
HKD2_k127_7262563_15 ABC transporter K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 428.0
HKD2_k127_7262563_16 ABC transporter K02049,K15578 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 407.0
HKD2_k127_7262563_17 Binding-protein-dependent transport system inner membrane component K02050,K15577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 412.0
HKD2_k127_7262563_18 NMT1-like family K15576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 386.0
HKD2_k127_7262563_19 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 368.0
HKD2_k127_7262563_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 1.657e-303 958.0
HKD2_k127_7262563_20 Protein of unknown function (DUF2848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 327.0
HKD2_k127_7262563_21 Bacterial protein of unknown function (DUF882) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 294.0
HKD2_k127_7262563_22 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 295.0
HKD2_k127_7262563_23 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008887 268.0
HKD2_k127_7262563_24 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001115 265.0
HKD2_k127_7262563_25 Bacterial protein of unknown function (DUF924) - - - 0.000000000000000000000000000000000000000000000000001093 190.0
HKD2_k127_7262563_26 response regulator receiver K07183 - - 0.00000000000000000000000000000000000000000000000005756 184.0
HKD2_k127_7262563_3 Sulfatase - - - 4.049e-291 903.0
HKD2_k127_7262563_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 2.888e-278 862.0
HKD2_k127_7262563_5 serine threonine protein kinase K08282 - 2.7.11.1 1.037e-275 859.0
HKD2_k127_7262563_6 CoA-transferase family III - - - 1.033e-240 746.0
HKD2_k127_7262563_7 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15576 - - 6.327e-204 646.0
HKD2_k127_7262563_8 PFAM nitrite and sulphite reductase 4Fe-4S K00366 - 1.7.7.1 2.479e-203 661.0
HKD2_k127_7262563_9 Protein of unknown function (DUF1445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 512.0
HKD2_k127_7540646_0 Involved in the TonB-independent uptake of proteins K03641 - - 1.496e-237 752.0
HKD2_k127_7540646_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 2.797e-200 627.0
HKD2_k127_7540646_10 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000000000000000001497 237.0
HKD2_k127_7540646_12 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000009918 89.0
HKD2_k127_7540646_2 Cell division and transport-associated protein TolA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 475.0
HKD2_k127_7540646_3 COG0811 Biopolymer transport proteins K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 441.0
HKD2_k127_7540646_4 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 417.0
HKD2_k127_7540646_5 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 331.0
HKD2_k127_7540646_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 306.0
HKD2_k127_7540646_7 Biopolymer transport protein K03560 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 291.0
HKD2_k127_7540646_8 thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005016 259.0
HKD2_k127_7540646_9 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000000000000000002354 234.0
HKD2_k127_7574401_0 Luciferase-like monooxygenase - - - 1.538e-246 766.0
HKD2_k127_7574401_1 FAD dependent oxidoreductase K19746 - 1.4.99.6 2.322e-198 625.0
HKD2_k127_7574401_10 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000001385 181.0
HKD2_k127_7574401_11 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000005563 173.0
HKD2_k127_7574401_12 - - - - 0.00000000000000011 82.0
HKD2_k127_7574401_13 - - - - 0.0000000001035 67.0
HKD2_k127_7574401_14 - - - - 0.00000006023 55.0
HKD2_k127_7574401_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 598.0
HKD2_k127_7574401_3 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 601.0
HKD2_k127_7574401_4 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 587.0
HKD2_k127_7574401_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009231 494.0
HKD2_k127_7574401_6 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 382.0
HKD2_k127_7574401_7 Major Facilitator Superfamily K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001157 292.0
HKD2_k127_7574401_8 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008325 238.0
HKD2_k127_7574401_9 'ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000002987 207.0
HKD2_k127_7638562_0 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0 1110.0
HKD2_k127_7638562_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.38e-253 787.0
HKD2_k127_7638562_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 517.0
HKD2_k127_7638562_11 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 484.0
HKD2_k127_7638562_12 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 453.0
HKD2_k127_7638562_13 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 434.0
HKD2_k127_7638562_14 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 424.0
HKD2_k127_7638562_15 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 429.0
HKD2_k127_7638562_16 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 406.0
HKD2_k127_7638562_17 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 389.0
HKD2_k127_7638562_18 kinase activity K01006,K01007,K22424 - 2.7.3.13,2.7.9.1,2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 325.0
HKD2_k127_7638562_19 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 314.0
HKD2_k127_7638562_2 P-aminobenzoate N-oxygenase AurF - - - 6.635e-222 691.0
HKD2_k127_7638562_20 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 319.0
HKD2_k127_7638562_21 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 305.0
HKD2_k127_7638562_22 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000845 297.0
HKD2_k127_7638562_23 Nad-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002531 271.0
HKD2_k127_7638562_24 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001401 252.0
HKD2_k127_7638562_25 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000006594 230.0
HKD2_k127_7638562_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000009909 220.0
HKD2_k127_7638562_27 AIG2-like family - - - 0.000000000000000000000000000000000000000000000000000000000025 211.0
HKD2_k127_7638562_28 carbonate dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000001889 203.0
HKD2_k127_7638562_29 PRC-barrel domain - - - 0.00000000000000000000000000000000000000000000000008221 181.0
HKD2_k127_7638562_3 alpha/beta hydrolase fold K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 590.0
HKD2_k127_7638562_30 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000001995 169.0
HKD2_k127_7638562_31 Domain of unknown function (DUF1476) - - - 0.00000000000000000000000000000000000000001125 155.0
HKD2_k127_7638562_32 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000005938 144.0
HKD2_k127_7638562_33 PFAM Glutathione S-transferase domain - - - 0.0000000000000000000000000000002084 131.0
HKD2_k127_7638562_4 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 572.0
HKD2_k127_7638562_5 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 567.0
HKD2_k127_7638562_6 FAD binding domain K05898,K13796 - 1.3.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 556.0
HKD2_k127_7638562_7 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 550.0
HKD2_k127_7638562_8 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 508.0
HKD2_k127_7638562_9 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 511.0
HKD2_k127_7672462_0 Amidase K02433 - 6.3.5.6,6.3.5.7 1.335e-235 735.0
HKD2_k127_7672462_1 FMN-dependent dehydrogenase K00104 - 1.1.3.15 1.993e-214 668.0
HKD2_k127_7672462_10 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000007894 156.0
HKD2_k127_7672462_11 CrcB-like protein, Camphor Resistance (CrcB) - - - 0.000000000000000000000000000002619 125.0
HKD2_k127_7672462_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000483 123.0
HKD2_k127_7672462_13 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000006621 115.0
HKD2_k127_7672462_2 Allophanate hydrolase K01457 - 3.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 586.0
HKD2_k127_7672462_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 469.0
HKD2_k127_7672462_4 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 333.0
HKD2_k127_7672462_5 PFAM Taurine catabolism dioxygenase TauD TfdA K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 297.0
HKD2_k127_7672462_6 Protein of unknown function (DUF3225) - - - 0.0000000000000000000000000000000000000000000000000000001641 201.0
HKD2_k127_7672462_7 serine-type endopeptidase activity K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000005192 198.0
HKD2_k127_7672462_8 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000000003523 168.0
HKD2_k127_7672462_9 methyltransferase - - - 0.0000000000000000000000000000000000000000000005846 184.0
HKD2_k127_7677508_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1232.0
HKD2_k127_7677508_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 5.247e-301 926.0
HKD2_k127_7677508_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 475.0
HKD2_k127_7677508_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 313.0
HKD2_k127_7677508_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 293.0
HKD2_k127_7677508_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000000000000000004334 223.0
HKD2_k127_768345_0 This protein is involved in the repair of mismatches in DNA K03555 - - 0.0 1525.0
HKD2_k127_768345_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 9.256e-207 644.0
HKD2_k127_768345_2 malic enzyme K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 609.0
HKD2_k127_768345_3 HemY protein N-terminus K02498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 523.0
HKD2_k127_768345_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 425.0
HKD2_k127_768345_5 - - - - 0.000000000000000000000000000000000000000000000769 172.0
HKD2_k127_7749132_0 MlrC C-terminus - - - 2.405e-287 888.0
HKD2_k127_7749132_1 COG1042 Acyl-CoA synthetase (NDP forming) - - - 5.523e-243 758.0
HKD2_k127_7749132_10 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 505.0
HKD2_k127_7749132_11 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 511.0
HKD2_k127_7749132_12 Phenylacetic acid catabolic protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006535 454.0
HKD2_k127_7749132_13 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 444.0
HKD2_k127_7749132_14 Pfam:Pyridox_oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 349.0
HKD2_k127_7749132_15 Hydantoin racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 335.0
HKD2_k127_7749132_16 Preprotein translocase subunit YajC K03210 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004826 247.0
HKD2_k127_7749132_17 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000000000001387 248.0
HKD2_k127_7749132_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000001664 234.0
HKD2_k127_7749132_19 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000000000000001876 214.0
HKD2_k127_7749132_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.884e-223 697.0
HKD2_k127_7749132_20 Transcriptional regulator, MarR family - - - 0.00000000000000000000000000000000000000000000000000000007768 214.0
HKD2_k127_7749132_21 Lipase (class 2) K01046 - 3.1.1.3 0.0007936 44.0
HKD2_k127_7749132_3 oxidoreductase FAD NAD(P)-binding domain protein K14581 - 1.18.1.7 6.156e-201 640.0
HKD2_k127_7749132_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.018e-200 658.0
HKD2_k127_7749132_5 general L-amino acid-binding periplasmic protein AapJ K09969 - - 7.294e-200 627.0
HKD2_k127_7749132_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 4.213e-195 612.0
HKD2_k127_7749132_7 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 598.0
HKD2_k127_7749132_8 ATPase (AAA K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 537.0
HKD2_k127_7749132_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 517.0
HKD2_k127_7754170_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.068e-314 971.0
HKD2_k127_7754170_1 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 6.823e-302 931.0
HKD2_k127_7754170_10 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 466.0
HKD2_k127_7754170_11 peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 456.0
HKD2_k127_7754170_12 to the N-terminal domain of Lon protease K01338,K07157 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 410.0
HKD2_k127_7754170_13 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 327.0
HKD2_k127_7754170_14 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 330.0
HKD2_k127_7754170_15 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 353.0
HKD2_k127_7754170_16 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001191 261.0
HKD2_k127_7754170_17 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002506 259.0
HKD2_k127_7754170_18 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001758 251.0
HKD2_k127_7754170_19 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001541 239.0
HKD2_k127_7754170_2 Heparinase II/III-like protein - - - 6.161e-288 893.0
HKD2_k127_7754170_20 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000000000000005293 186.0
HKD2_k127_7754170_21 Cupin domain - - - 0.00000000000000000000000000000000000000000002443 167.0
HKD2_k127_7754170_22 Cytochrome b/b6/petB - - - 0.000000000000000000000000000000000000000000131 164.0
HKD2_k127_7754170_25 Peptidase propeptide and YPEB domain - - - 0.00000000000000000000000000006643 118.0
HKD2_k127_7754170_26 Belongs to the UPF0434 family K09791 - - 0.000000000000000000000000000393 115.0
HKD2_k127_7754170_27 Tautomerase enzyme - - - 0.00000000000000000000000001418 119.0
HKD2_k127_7754170_28 ClpX C4-type zinc finger - - - 0.00000000000000000000001043 105.0
HKD2_k127_7754170_3 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 4.152e-281 867.0
HKD2_k127_7754170_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 2.734e-277 859.0
HKD2_k127_7754170_5 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 2.779e-265 824.0
HKD2_k127_7754170_6 FAD binding domain K20940 - 1.14.13.218 8.834e-237 736.0
HKD2_k127_7754170_7 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 3.418e-194 616.0
HKD2_k127_7754170_8 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005986 500.0
HKD2_k127_7754170_9 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 508.0
HKD2_k127_7789179_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 2.236e-294 912.0
HKD2_k127_7789179_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.276e-208 660.0
HKD2_k127_7789179_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 419.0
HKD2_k127_7789179_3 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 412.0
HKD2_k127_7789179_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 366.0
HKD2_k127_7789179_5 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 319.0
HKD2_k127_7789179_6 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000001182 216.0
HKD2_k127_7802879_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1866.0
HKD2_k127_7802879_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.324e-256 795.0
HKD2_k127_7802879_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 324.0
HKD2_k127_7802879_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 295.0
HKD2_k127_7802879_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002132 245.0
HKD2_k127_7843038_0 monooxygenase - - - 2.776e-225 711.0
HKD2_k127_7843038_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.194e-210 672.0
HKD2_k127_7843038_10 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 327.0
HKD2_k127_7843038_11 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002246 247.0
HKD2_k127_7843038_12 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000004604 222.0
HKD2_k127_7843038_13 - - - - 0.000000000000000000000000000000000000000000000000000000000001503 218.0
HKD2_k127_7843038_14 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000002253 227.0
HKD2_k127_7843038_15 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000006406 171.0
HKD2_k127_7843038_16 Catalyzes the conversion of maleate to fumarate K01799,K06033 - 4.1.1.76,5.2.1.1 0.000000000000000000000000002571 120.0
HKD2_k127_7843038_17 - - - - 0.000000000005925 70.0
HKD2_k127_7843038_2 PFAM amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 544.0
HKD2_k127_7843038_20 Ribonuclease H protein K20164 - - 0.0001078 54.0
HKD2_k127_7843038_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 462.0
HKD2_k127_7843038_4 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 424.0
HKD2_k127_7843038_5 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 422.0
HKD2_k127_7843038_6 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007148 404.0
HKD2_k127_7843038_7 flavin adenine dinucleotide binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 344.0
HKD2_k127_7843038_8 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 331.0
HKD2_k127_7843038_9 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 334.0
HKD2_k127_7885407_0 Competence protein K02238 - - 0.0 1177.0
HKD2_k127_7885407_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.679e-280 863.0
HKD2_k127_7885407_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.305e-266 826.0
HKD2_k127_7885407_3 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 1.118e-216 678.0
HKD2_k127_7885407_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 428.0
HKD2_k127_7885407_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 422.0
HKD2_k127_7885407_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009724 323.0
HKD2_k127_7885407_7 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 286.0
HKD2_k127_7885407_8 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000002572 196.0
HKD2_k127_7908797_0 NAD synthase K01950 - 6.3.5.1 0.0 1188.0
HKD2_k127_7908797_1 AMP-binding enzyme C-terminal domain - - - 5.947e-283 875.0
HKD2_k127_7908797_10 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000134 44.0
HKD2_k127_7908797_2 III protein, CoA-transferase family - - - 2.147e-232 721.0
HKD2_k127_7908797_3 hydroxy-methylglutaryl-CoA lyase K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 577.0
HKD2_k127_7908797_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 534.0
HKD2_k127_7908797_5 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 297.0
HKD2_k127_7908797_6 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009775 256.0
HKD2_k127_7908797_7 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002237 239.0
HKD2_k127_7908797_8 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000000000000000000000000000000000000000002541 223.0
HKD2_k127_7908797_9 Sterol carrier protein - - - 0.00000000000000000000000000000000000000000000000000000000001152 225.0
HKD2_k127_7944382_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812,K08351 - 1.7.2.3 0.0 1356.0
HKD2_k127_7944382_1 Sulfatase K01130 - 3.1.6.1 0.0 1308.0
HKD2_k127_7944382_10 Nitrogen fixation protein fixG - - - 2.95e-262 813.0
HKD2_k127_7944382_11 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.951e-260 812.0
HKD2_k127_7944382_12 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.025e-255 789.0
HKD2_k127_7944382_13 Amidohydrolase family K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 3.17e-252 792.0
HKD2_k127_7944382_14 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 2.975e-240 779.0
HKD2_k127_7944382_15 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 4.134e-240 759.0
HKD2_k127_7944382_16 Bacterial extracellular solute-binding protein - - - 1.364e-234 734.0
HKD2_k127_7944382_17 Aminotransferase class I and II - - - 1.33e-230 719.0
HKD2_k127_7944382_18 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 1.489e-225 707.0
HKD2_k127_7944382_19 COG3839 ABC-type sugar transport systems, ATPase components - - - 2.271e-220 685.0
HKD2_k127_7944382_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0 1287.0
HKD2_k127_7944382_20 Adenylate cyclase - - - 5.946e-219 690.0
HKD2_k127_7944382_21 Malate/L-lactate dehydrogenase - - - 2.458e-213 664.0
HKD2_k127_7944382_22 Doubled CXXCH motif (Paired_CXXCH_1) - - - 4.725e-204 662.0
HKD2_k127_7944382_23 His Kinase A (phosphoacceptor) domain - - - 1.06e-201 650.0
HKD2_k127_7944382_24 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 594.0
HKD2_k127_7944382_25 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 566.0
HKD2_k127_7944382_26 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 557.0
HKD2_k127_7944382_27 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 554.0
HKD2_k127_7944382_28 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 554.0
HKD2_k127_7944382_29 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009236 558.0
HKD2_k127_7944382_3 Sulfatase K01130 - 3.1.6.1 0.0 1272.0
HKD2_k127_7944382_30 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 550.0
HKD2_k127_7944382_31 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 546.0
HKD2_k127_7944382_32 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 533.0
HKD2_k127_7944382_33 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 527.0
HKD2_k127_7944382_34 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 517.0
HKD2_k127_7944382_35 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 520.0
HKD2_k127_7944382_36 SbmA/BacA-like family K02471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 522.0
HKD2_k127_7944382_37 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 478.0
HKD2_k127_7944382_38 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008823 465.0
HKD2_k127_7944382_39 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 444.0
HKD2_k127_7944382_4 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0 1206.0
HKD2_k127_7944382_40 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 429.0
HKD2_k127_7944382_41 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 424.0
HKD2_k127_7944382_42 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 430.0
HKD2_k127_7944382_43 Universal stress protein UspA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 415.0
HKD2_k127_7944382_44 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 402.0
HKD2_k127_7944382_45 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 415.0
HKD2_k127_7944382_46 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 387.0
HKD2_k127_7944382_47 Choline/ethanolamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 381.0
HKD2_k127_7944382_48 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 372.0
HKD2_k127_7944382_49 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008745 378.0
HKD2_k127_7944382_5 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.0 1175.0
HKD2_k127_7944382_50 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 353.0
HKD2_k127_7944382_51 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 350.0
HKD2_k127_7944382_52 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 328.0
HKD2_k127_7944382_53 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 307.0
HKD2_k127_7944382_54 helix_turn_helix, cAMP Regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 297.0
HKD2_k127_7944382_55 BON domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 300.0
HKD2_k127_7944382_56 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 289.0
HKD2_k127_7944382_57 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007811 280.0
HKD2_k127_7944382_58 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002348 263.0
HKD2_k127_7944382_59 BON domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005868 250.0
HKD2_k127_7944382_6 COG0474 Cation transport ATPase K01537 - 3.6.3.8 0.0 1157.0
HKD2_k127_7944382_60 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001697 244.0
HKD2_k127_7944382_61 helix_turn_helix, Lux Regulon K14987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002396 250.0
HKD2_k127_7944382_62 FixH - - - 0.000000000000000000000000000000000000000000000000000000000000000936 224.0
HKD2_k127_7944382_63 - - - - 0.000000000000000000000000000000000000000000000000000000000000004763 219.0
HKD2_k127_7944382_64 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000005616 209.0
HKD2_k127_7944382_65 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000006735 225.0
HKD2_k127_7944382_66 'PFAM Response regulator receiver - - - 0.0000000000000000000000000000000000000002157 153.0
HKD2_k127_7944382_67 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000004279 117.0
HKD2_k127_7944382_69 FecR protein - - - 0.00000000000000000000004131 113.0
HKD2_k127_7944382_7 Belongs to the TPP enzyme family K01576 - 4.1.1.7 4.467e-314 967.0
HKD2_k127_7944382_70 - - - - 0.000000000000000000003945 99.0
HKD2_k127_7944382_71 - - - - 0.000000000000000000004459 107.0
HKD2_k127_7944382_75 Tetratricopeptide repeat - - - 0.0000000000000004115 85.0
HKD2_k127_7944382_76 cytochrome oxidase maturation protein - - - 0.00000000000001164 87.0
HKD2_k127_7944382_77 - - - - 0.00000000000003003 81.0
HKD2_k127_7944382_8 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 9.798e-303 932.0
HKD2_k127_7944382_9 COG0659 Sulfate permease and related transporters (MFS superfamily) - - - 4.797e-266 832.0
HKD2_k127_795526_0 - - - - 0.0 1088.0
HKD2_k127_795526_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 7.555e-289 894.0
HKD2_k127_795526_10 - - - - 0.000000000001359 72.0
HKD2_k127_795526_2 Ketopantoate reductase PanE/ApbA C terminal - - - 1.039e-207 648.0
HKD2_k127_795526_3 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 3.561e-206 645.0
HKD2_k127_795526_4 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 584.0
HKD2_k127_795526_5 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 441.0
HKD2_k127_795526_6 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 299.0
HKD2_k127_795526_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002452 272.0
HKD2_k127_795526_8 - - - - 0.000000000000000000000000000000000002261 149.0
HKD2_k127_795526_9 - - - - 0.0000000000000000000005973 111.0
HKD2_k127_7963014_0 COG2873 O-acetylhomoserine sulfhydrylase K01738,K01740 - 2.5.1.47,2.5.1.49 5.603e-258 797.0
HKD2_k127_7963014_1 Histidine kinase - - - 6.778e-224 703.0
HKD2_k127_7963014_2 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 565.0
HKD2_k127_7963014_3 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001078 246.0
HKD2_k127_7963014_4 Cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000003942 154.0
HKD2_k127_8021076_0 DNA helicase K03657 - 3.6.4.12 0.0 1432.0
HKD2_k127_8021076_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0 1232.0
HKD2_k127_8021076_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 469.0
HKD2_k127_8021076_11 Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 477.0
HKD2_k127_8021076_12 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 443.0
HKD2_k127_8021076_13 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 432.0
HKD2_k127_8021076_14 ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 425.0
HKD2_k127_8021076_15 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 393.0
HKD2_k127_8021076_16 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 372.0
HKD2_k127_8021076_17 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 356.0
HKD2_k127_8021076_18 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 304.0
HKD2_k127_8021076_19 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 311.0
HKD2_k127_8021076_2 aminopeptidase K01262 - 3.4.11.9 0.0 1085.0
HKD2_k127_8021076_20 TRANSCRIPTIONal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 304.0
HKD2_k127_8021076_21 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006032 275.0
HKD2_k127_8021076_22 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008875 265.0
HKD2_k127_8021076_23 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001377 279.0
HKD2_k127_8021076_24 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000003317 284.0
HKD2_k127_8021076_25 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000006977 239.0
HKD2_k127_8021076_26 Transcriptional regulatory protein, C terminal K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000007857 242.0
HKD2_k127_8021076_27 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000000000002592 203.0
HKD2_k127_8021076_29 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.000000000000000000000000000000000000000000000000816 181.0
HKD2_k127_8021076_3 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 7.771e-301 925.0
HKD2_k127_8021076_31 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000001719 165.0
HKD2_k127_8021076_32 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000001667 99.0
HKD2_k127_8021076_34 SnoaL-like polyketide cyclase - - - 0.0003006 46.0
HKD2_k127_8021076_4 May be involved in recombinational repair of damaged DNA K03631 - - 1.826e-273 849.0
HKD2_k127_8021076_5 Thiolase, C-terminal domain - - - 4.408e-258 797.0
HKD2_k127_8021076_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.551e-227 716.0
HKD2_k127_8021076_7 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 599.0
HKD2_k127_8021076_8 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 544.0
HKD2_k127_8021076_9 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 506.0
HKD2_k127_8021382_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1777.0
HKD2_k127_8021382_1 DEAD/H associated K03724 - - 0.0 1497.0
HKD2_k127_8021382_10 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 7.623e-205 639.0
HKD2_k127_8021382_11 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 4.928e-203 633.0
HKD2_k127_8021382_12 Required for the activity of the bacterial periplasmic transport system of putrescine K11069,K11073 - - 9.801e-200 625.0
HKD2_k127_8021382_13 Glycosyl transferase family 2 K00721,K10012 - 2.4.1.83,2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 598.0
HKD2_k127_8021382_14 Benzoate membrane transport protein K05782 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 567.0
HKD2_k127_8021382_15 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 550.0
HKD2_k127_8021382_16 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 586.0
HKD2_k127_8021382_17 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 537.0
HKD2_k127_8021382_18 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 554.0
HKD2_k127_8021382_19 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 522.0
HKD2_k127_8021382_2 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 1.612e-315 972.0
HKD2_k127_8021382_20 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 517.0
HKD2_k127_8021382_21 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 512.0
HKD2_k127_8021382_22 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008653 488.0
HKD2_k127_8021382_23 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 484.0
HKD2_k127_8021382_24 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 488.0
HKD2_k127_8021382_25 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 485.0
HKD2_k127_8021382_26 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 485.0
HKD2_k127_8021382_27 Binding-protein-dependent transport system inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 471.0
HKD2_k127_8021382_28 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 441.0
HKD2_k127_8021382_29 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 432.0
HKD2_k127_8021382_3 ATP dependent DNA ligase C terminal region K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.126e-311 970.0
HKD2_k127_8021382_30 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008894 426.0
HKD2_k127_8021382_31 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 410.0
HKD2_k127_8021382_32 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 396.0
HKD2_k127_8021382_33 SOS response K14160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 380.0
HKD2_k127_8021382_35 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 323.0
HKD2_k127_8021382_36 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002695 274.0
HKD2_k127_8021382_37 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006425 269.0
HKD2_k127_8021382_38 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002089 249.0
HKD2_k127_8021382_39 Thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007103 239.0
HKD2_k127_8021382_4 polysaccharide biosynthetic process - - - 4.665e-286 884.0
HKD2_k127_8021382_40 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006841 236.0
HKD2_k127_8021382_41 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000000000000000000000000000008371 222.0
HKD2_k127_8021382_42 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000005197 199.0
HKD2_k127_8021382_43 Transcriptional - - - 0.000000000000000000000000000000000000000000000003595 173.0
HKD2_k127_8021382_45 Cytochrome c1 - - - 0.000000000000000000000000000000000000383 142.0
HKD2_k127_8021382_46 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000004183 116.0
HKD2_k127_8021382_5 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 1.126e-281 876.0
HKD2_k127_8021382_6 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 1.09e-247 775.0
HKD2_k127_8021382_7 L-carnitine dehydratase bile acid-inducible protein F - - - 3.75e-221 690.0
HKD2_k127_8021382_8 Uncharacterized protein conserved in bacteria (DUF2252) - - - 2.907e-209 665.0
HKD2_k127_8021382_9 Mo-co oxidoreductase dimerisation domain - - - 7.714e-206 646.0
HKD2_k127_8040410_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1313.0
HKD2_k127_8040410_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1097.0
HKD2_k127_8040410_10 COG0477 Permeases of the major facilitator superfamily - - - 8.671e-214 669.0
HKD2_k127_8040410_11 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 5.578e-195 620.0
HKD2_k127_8040410_12 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 611.0
HKD2_k127_8040410_13 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 558.0
HKD2_k127_8040410_14 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 556.0
HKD2_k127_8040410_15 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000527 552.0
HKD2_k127_8040410_16 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 547.0
HKD2_k127_8040410_17 Cytidylyltransferase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 542.0
HKD2_k127_8040410_18 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 501.0
HKD2_k127_8040410_2 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 0.0 1011.0
HKD2_k127_8040410_20 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 498.0
HKD2_k127_8040410_21 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 459.0
HKD2_k127_8040410_22 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 456.0
HKD2_k127_8040410_23 Domain of unknown function (DUF1849) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 441.0
HKD2_k127_8040410_24 3-beta hydroxysteroid dehydrogenase/isomerase family K01784,K02473,K03274,K08678 - 4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 425.0
HKD2_k127_8040410_25 membrane protein involved in D-alanine export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 428.0
HKD2_k127_8040410_26 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 411.0
HKD2_k127_8040410_27 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 389.0
HKD2_k127_8040410_28 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 382.0
HKD2_k127_8040410_29 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 374.0
HKD2_k127_8040410_3 Glycosyl transferase, family 2 - - - 4.601e-299 922.0
HKD2_k127_8040410_30 COG0593 ATPase involved in DNA replication initiation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 349.0
HKD2_k127_8040410_31 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 339.0
HKD2_k127_8040410_32 phytanoyl-CoA dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 312.0
HKD2_k127_8040410_33 COG1335 Amidases related to nicotinamidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 310.0
HKD2_k127_8040410_34 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002393 287.0
HKD2_k127_8040410_35 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001491 286.0
HKD2_k127_8040410_36 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001319 259.0
HKD2_k127_8040410_37 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005981 246.0
HKD2_k127_8040410_38 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000001232 250.0
HKD2_k127_8040410_39 Histidine phosphatase superfamily (branch 1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001674 245.0
HKD2_k127_8040410_4 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 7.625e-281 869.0
HKD2_k127_8040410_40 Phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000000000000000000000000000000000000000000002444 222.0
HKD2_k127_8040410_41 SIS domain K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000002049 221.0
HKD2_k127_8040410_42 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000003217 235.0
HKD2_k127_8040410_43 Histidine phosphatase superfamily (branch 1) - - - 0.0000000000000000000000000000000000000000000000000000000000001516 220.0
HKD2_k127_8040410_44 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000002156 223.0
HKD2_k127_8040410_45 - - - - 0.000000000000000000000000000000000000000000005477 168.0
HKD2_k127_8040410_46 phosphoglycolate phosphatase activity - - - 0.000000000000000000000000000000000000000007834 164.0
HKD2_k127_8040410_47 NUDIX domain - - - 0.000000000000000000000000000000000000007807 153.0
HKD2_k127_8040410_48 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000002973 148.0
HKD2_k127_8040410_49 RmlD substrate binding domain K00067 - 1.1.1.133 0.0000000000000000000000000000003943 134.0
HKD2_k127_8040410_5 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 - 3.2.2.4 9.583e-277 856.0
HKD2_k127_8040410_50 - - - - 0.00000000000000000000000000001575 130.0
HKD2_k127_8040410_52 Transposase DDE domain - - - 0.00000000002503 63.0
HKD2_k127_8040410_53 COG COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K01992,K09690 - - 0.0000000001052 72.0
HKD2_k127_8040410_54 - - - - 0.00000005918 64.0
HKD2_k127_8040410_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - 2.92e-237 739.0
HKD2_k127_8040410_7 Putative cyclase - - - 2.536e-224 696.0
HKD2_k127_8040410_8 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 5.608e-221 689.0
HKD2_k127_8040410_9 Luciferase-like monooxygenase - - - 4.883e-217 702.0
HKD2_k127_8110927_0 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 0.0 1399.0
HKD2_k127_8110927_1 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0 1025.0
HKD2_k127_8110927_10 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 494.0
HKD2_k127_8110927_11 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 497.0
HKD2_k127_8110927_12 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 439.0
HKD2_k127_8110927_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005288 442.0
HKD2_k127_8110927_14 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 434.0
HKD2_k127_8110927_15 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 371.0
HKD2_k127_8110927_16 COG0512 Anthranilate para-aminobenzoate synthases component II K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 361.0
HKD2_k127_8110927_17 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 357.0
HKD2_k127_8110927_19 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 324.0
HKD2_k127_8110927_2 PFAM AMP-dependent synthetase and ligase K00666 - - 1.036e-300 952.0
HKD2_k127_8110927_20 Dienelactone hydrolase family K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002659 279.0
HKD2_k127_8110927_21 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002156 277.0
HKD2_k127_8110927_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004819 270.0
HKD2_k127_8110927_23 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000051 255.0
HKD2_k127_8110927_24 Protein of unknown function (DUF1194) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004832 251.0
HKD2_k127_8110927_25 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.00000000000000000000000000000000000000000000000000000001227 199.0
HKD2_k127_8110927_26 - - - - 0.00000000000000000000000000000000000000000000000000000001752 212.0
HKD2_k127_8110927_28 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000002539 179.0
HKD2_k127_8110927_3 Acyl-CoA dehydrogenase, middle domain - - - 2.587e-262 815.0
HKD2_k127_8110927_30 HWE histidine kinase - - - 0.00000000000000000000000000000001653 136.0
HKD2_k127_8110927_31 - - - - 0.00000000000000000000000000001415 123.0
HKD2_k127_8110927_4 Acyl-CoA dehydrogenase, middle domain - - - 1.991e-253 784.0
HKD2_k127_8110927_6 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 4.679e-207 662.0
HKD2_k127_8110927_7 protein conserved in bacteria K09798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 537.0
HKD2_k127_8110927_8 TIGRFAM FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family K20938 - 1.14.14.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 533.0
HKD2_k127_8110927_9 of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000939 511.0
HKD2_k127_8117959_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 2.426e-297 919.0
HKD2_k127_8117959_1 Autotransporter beta-domain - - - 3.51e-297 940.0
HKD2_k127_8117959_10 geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 328.0
HKD2_k127_8117959_11 GMP synthase (glutamine-hydrolyzing) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006617 283.0
HKD2_k127_8117959_12 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009286 234.0
HKD2_k127_8117959_13 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000008176 219.0
HKD2_k127_8117959_14 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000000004428 165.0
HKD2_k127_8117959_15 transcriptional regulator, ArsR family - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000006005 143.0
HKD2_k127_8117959_2 peptidase U62, modulator of DNA gyrase K03568 - - 7.699e-278 859.0
HKD2_k127_8117959_3 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 3.878e-259 802.0
HKD2_k127_8117959_4 Radical SAM K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 607.0
HKD2_k127_8117959_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 569.0
HKD2_k127_8117959_6 FAD dependent oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007761 530.0
HKD2_k127_8117959_7 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 435.0
HKD2_k127_8117959_8 Radical SAM K09711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 437.0
HKD2_k127_8117959_9 biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 379.0
HKD2_k127_8182397_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 444.0
HKD2_k127_8182397_1 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 404.0
HKD2_k127_8182397_2 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001388 282.0
HKD2_k127_8182397_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001116 285.0
HKD2_k127_8182397_4 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000000000002785 138.0
HKD2_k127_8198465_0 malic enzyme K00029 - 1.1.1.40 0.0 1369.0
HKD2_k127_8198465_1 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 0.0 1129.0
HKD2_k127_8198465_10 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 444.0
HKD2_k127_8198465_11 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 439.0
HKD2_k127_8198465_12 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 400.0
HKD2_k127_8198465_13 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 390.0
HKD2_k127_8198465_14 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 388.0
HKD2_k127_8198465_15 COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 359.0
HKD2_k127_8198465_16 COG1024 Enoyl-CoA hydratase carnithine racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 296.0
HKD2_k127_8198465_17 WHG domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 284.0
HKD2_k127_8198465_18 Glutathione peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005626 280.0
HKD2_k127_8198465_19 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000002182 233.0
HKD2_k127_8198465_2 AsmA family K07289,K07290 - - 0.0 1012.0
HKD2_k127_8198465_20 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000439 215.0
HKD2_k127_8198465_21 - - - - 0.00000000000000000000000000000000000000000000000001548 183.0
HKD2_k127_8198465_22 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000000000000000000000000003265 158.0
HKD2_k127_8198465_23 transposase activity - - - 0.0000000000000000000000002575 121.0
HKD2_k127_8198465_3 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 2.962e-317 974.0
HKD2_k127_8198465_4 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 3.883e-268 844.0
HKD2_k127_8198465_5 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 5.819e-245 760.0
HKD2_k127_8198465_6 Acts as a magnesium transporter K06213 - - 5.393e-218 711.0
HKD2_k127_8198465_7 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 570.0
HKD2_k127_8198465_8 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008056 510.0
HKD2_k127_8198465_9 COG2041 Sulfite oxidase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 450.0
HKD2_k127_828438_0 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.0 1236.0
HKD2_k127_828438_1 COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain K06147 - - 0.0 1110.0
HKD2_k127_828438_10 COG1960 Acyl-CoA dehydrogenases - - - 8.773e-244 758.0
HKD2_k127_828438_11 Sulfide dehydrogenase - - - 1.684e-222 694.0
HKD2_k127_828438_12 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 606.0
HKD2_k127_828438_13 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008528 591.0
HKD2_k127_828438_14 COG1702 Phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 573.0
HKD2_k127_828438_15 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009739 538.0
HKD2_k127_828438_16 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 522.0
HKD2_k127_828438_17 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 518.0
HKD2_k127_828438_18 COG1253 Hemolysins and related proteins containing CBS domains K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 511.0
HKD2_k127_828438_19 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 504.0
HKD2_k127_828438_2 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0 1014.0
HKD2_k127_828438_20 Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 486.0
HKD2_k127_828438_21 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 467.0
HKD2_k127_828438_22 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 448.0
HKD2_k127_828438_23 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 447.0
HKD2_k127_828438_24 FlgJ-related protein K03796 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 448.0
HKD2_k127_828438_25 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 438.0
HKD2_k127_828438_26 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 406.0
HKD2_k127_828438_27 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 395.0
HKD2_k127_828438_28 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 403.0
HKD2_k127_828438_29 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 381.0
HKD2_k127_828438_3 SbmA/BacA-like family K02471 - - 0.0 1012.0
HKD2_k127_828438_30 Cytochrome c, mono- and diheme variants - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 385.0
HKD2_k127_828438_31 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 376.0
HKD2_k127_828438_32 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 359.0
HKD2_k127_828438_33 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 341.0
HKD2_k127_828438_34 COG0694 Thioredoxin-like proteins and domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 331.0
HKD2_k127_828438_35 transcriptional regulator K05800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 293.0
HKD2_k127_828438_36 PFAM Alpha beta hydrolase fold-3 domain protein K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 291.0
HKD2_k127_828438_37 tRNA threonylcarbamoyladenosine modification K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 284.0
HKD2_k127_828438_38 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002459 263.0
HKD2_k127_828438_39 universal stress protein UspA and related nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003879 263.0
HKD2_k127_828438_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 6.155e-305 940.0
HKD2_k127_828438_40 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001219 241.0
HKD2_k127_828438_41 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002735 240.0
HKD2_k127_828438_42 DNA repair protein MmcB-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000002049 252.0
HKD2_k127_828438_43 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000009864 216.0
HKD2_k127_828438_44 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000199 214.0
HKD2_k127_828438_45 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000000004152 211.0
HKD2_k127_828438_46 sulfur oxidation protein (SoxY) K17226 - - 0.000000000000000000000000000000000000000000000000000000005123 201.0
HKD2_k127_828438_47 Cytochrome C' - - - 0.00000000000000000000000000000000000000000000000000000003205 201.0
HKD2_k127_828438_48 cytochrome c K17223 - - 0.0000000000000000000000000000000000000000000000000000004898 211.0
HKD2_k127_828438_49 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000001525 197.0
HKD2_k127_828438_5 Belongs to the TPP enzyme family K01576 - 4.1.1.7 1.372e-294 912.0
HKD2_k127_828438_50 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000002919 185.0
HKD2_k127_828438_51 Sulphur oxidation protein SoxZ K17227 - - 0.00000000000000000000000000000000000000001604 162.0
HKD2_k127_828438_52 Ion channel - - - 0.00000000000000000000000000000000000009275 149.0
HKD2_k127_828438_54 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000000000006247 119.0
HKD2_k127_828438_55 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000001006 115.0
HKD2_k127_828438_56 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000271 117.0
HKD2_k127_828438_58 Integrase core domain - - - 0.0008282 42.0
HKD2_k127_828438_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 7.37e-267 824.0
HKD2_k127_828438_7 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 6.511e-260 806.0
HKD2_k127_828438_8 protein conserved in bacteria K09989 - - 9.36e-255 788.0
HKD2_k127_828438_9 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 2.082e-244 765.0
HKD2_k127_8373180_0 Penicillin amidase K01434 - 3.5.1.11 0.0 1366.0
HKD2_k127_8373180_1 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 4.313e-259 805.0
HKD2_k127_8373180_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 522.0
HKD2_k127_8373180_11 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 487.0
HKD2_k127_8373180_12 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 485.0
HKD2_k127_8373180_13 Penicillin-insensitive murein endopeptidase K07261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009441 471.0
HKD2_k127_8373180_14 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 443.0
HKD2_k127_8373180_15 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007493 449.0
HKD2_k127_8373180_16 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 371.0
HKD2_k127_8373180_17 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 376.0
HKD2_k127_8373180_18 isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 367.0
HKD2_k127_8373180_19 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 328.0
HKD2_k127_8373180_2 COG1960 Acyl-CoA dehydrogenases - - - 2.771e-231 718.0
HKD2_k127_8373180_20 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 292.0
HKD2_k127_8373180_21 PFAM NnrUfamily protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002606 280.0
HKD2_k127_8373180_22 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001565 290.0
HKD2_k127_8373180_23 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001672 270.0
HKD2_k127_8373180_24 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004735 277.0
HKD2_k127_8373180_25 Exodeoxyribonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007367 252.0
HKD2_k127_8373180_26 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007357 246.0
HKD2_k127_8373180_27 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001878 243.0
HKD2_k127_8373180_28 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000009037 239.0
HKD2_k127_8373180_29 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000008546 211.0
HKD2_k127_8373180_3 Aminotransferase class I and II - - - 7.256e-226 703.0
HKD2_k127_8373180_30 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000004228 216.0
HKD2_k127_8373180_31 - - - - 0.000000000000000000000000000000000000000000000000001552 204.0
HKD2_k127_8373180_32 PFAM Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000000000002953 180.0
HKD2_k127_8373180_34 Periplasmic Protein K09914 - - 0.000000000000000000000000000007011 123.0
HKD2_k127_8373180_36 SmpA / OmlA family - - - 0.0000000000000000000001768 112.0
HKD2_k127_8373180_37 PFAM amidohydrolase 2 - - - 0.0000000000000000000005279 105.0
HKD2_k127_8373180_4 CoA-transferase family III K18702 - 2.8.3.19 2.173e-223 695.0
HKD2_k127_8373180_42 - - - - 0.00001567 53.0
HKD2_k127_8373180_5 transport protein CorA K03284 - - 2.14e-204 643.0
HKD2_k127_8373180_6 Belongs to the ALAD family K01698 - 4.2.1.24 5.755e-198 619.0
HKD2_k127_8373180_7 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 601.0
HKD2_k127_8373180_8 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 535.0
HKD2_k127_8373180_9 COG0625 Glutathione S-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009249 526.0
HKD2_k127_848108_0 cobalamin synthesis protein - - - 2.863e-223 695.0
HKD2_k127_848108_1 Aconitase family (aconitate hydratase) - - - 8.933e-220 691.0
HKD2_k127_848108_2 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009504 439.0
HKD2_k127_848108_3 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 396.0
HKD2_k127_848108_4 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 383.0
HKD2_k127_848108_5 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 383.0
HKD2_k127_848108_6 CHAD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 349.0
HKD2_k127_848108_7 Flavin reductase like domain K09024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 312.0
HKD2_k127_848108_8 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000001611 240.0
HKD2_k127_848108_9 - - - - 0.000001426 51.0
HKD2_k127_8514925_0 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 526.0
HKD2_k127_8514925_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 360.0
HKD2_k127_8514925_4 Ami_2 - - - 0.000004284 53.0
HKD2_k127_8607823_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01999 - - 4.162e-222 694.0
HKD2_k127_8607823_1 Amidase - - - 1.58e-210 661.0
HKD2_k127_8607823_10 ATPases associated with a variety of cellular activities K01996,K11963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 319.0
HKD2_k127_8607823_11 TOBE domain K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 313.0
HKD2_k127_8607823_12 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000006803 172.0
HKD2_k127_8607823_13 dioxygenase K16320,K18243 - 1.14.12.1,1.14.13.172 0.0000000000000000000000000000000000004429 145.0
HKD2_k127_8607823_14 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000008095 129.0
HKD2_k127_8607823_15 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000005101 132.0
HKD2_k127_8607823_16 Heavy-metal-associated domain - - - 0.00000000002552 71.0
HKD2_k127_8607823_2 FAD binding domain K00480,K14974 - 1.14.13.1,1.14.13.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 505.0
HKD2_k127_8607823_3 Belongs to the binding-protein-dependent transport system permease family K01998,K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 456.0
HKD2_k127_8607823_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 437.0
HKD2_k127_8607823_5 Belongs to the binding-protein-dependent transport system permease family K01997,K11960 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 428.0
HKD2_k127_8607823_6 Ring hydroxylating alpha subunit (catalytic domain) K16319 - 1.14.12.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 426.0
HKD2_k127_8607823_7 Periplasmic binding protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007352 366.0
HKD2_k127_8607823_8 ATPases associated with a variety of cellular activities K01995,K11962 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 371.0
HKD2_k127_8607823_9 helix-turn-helix- domain containing protein, AraC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 343.0
HKD2_k127_864721_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 5e-324 996.0
HKD2_k127_864721_1 AMP-binding enzyme K00666 - - 5.763e-308 953.0
HKD2_k127_864721_10 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 602.0
HKD2_k127_864721_11 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 535.0
HKD2_k127_864721_12 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 522.0
HKD2_k127_864721_13 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 524.0
HKD2_k127_864721_14 COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 474.0
HKD2_k127_864721_15 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000554 454.0
HKD2_k127_864721_16 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 446.0
HKD2_k127_864721_17 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 391.0
HKD2_k127_864721_18 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 391.0
HKD2_k127_864721_19 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 383.0
HKD2_k127_864721_2 Cys/Met metabolism PLP-dependent enzyme K00652,K00654 - 2.3.1.47,2.3.1.50 9.459e-244 756.0
HKD2_k127_864721_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 377.0
HKD2_k127_864721_21 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 378.0
HKD2_k127_864721_22 Abc-type multidrug transport system, permease component K01992 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 356.0
HKD2_k127_864721_23 decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 334.0
HKD2_k127_864721_24 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 322.0
HKD2_k127_864721_25 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 295.0
HKD2_k127_864721_26 secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 290.0
HKD2_k127_864721_27 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002403 275.0
HKD2_k127_864721_28 Domain of unknown function (DUF4439) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000472 273.0
HKD2_k127_864721_3 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 1.73e-240 747.0
HKD2_k127_864721_30 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000377 233.0
HKD2_k127_864721_31 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000000000000000001283 229.0
HKD2_k127_864721_32 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.000000000000000000000000000000000000000000000000000000001964 206.0
HKD2_k127_864721_33 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000000000000006114 198.0
HKD2_k127_864721_34 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000003328 178.0
HKD2_k127_864721_35 Cytochrome c - - - 0.0000000000000000000000000000000000000000000008635 174.0
HKD2_k127_864721_36 Phosphopantetheine attachment site - - - 0.00000000000000000000000000000000000001151 147.0
HKD2_k127_864721_37 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000001729 139.0
HKD2_k127_864721_38 NIPSNAP - - - 0.0000000000000000000000000000000004082 136.0
HKD2_k127_864721_39 Cation efflux family - - - 0.000000002482 67.0
HKD2_k127_864721_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.324e-233 739.0
HKD2_k127_864721_40 Cation efflux family - - - 0.00000001456 65.0
HKD2_k127_864721_5 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 1.38e-230 718.0
HKD2_k127_864721_6 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 6.13e-222 691.0
HKD2_k127_864721_7 III protein, CoA-transferase family K07749 - 2.8.3.16 1.253e-214 671.0
HKD2_k127_864721_8 OpgC protein - - - 8.416e-196 615.0
HKD2_k127_864721_9 pfam abc K01990,K01992,K09695 - - 1.097e-195 631.0
HKD2_k127_8655850_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1609.0
HKD2_k127_8655850_1 Sodium/hydrogen exchanger family K03316 - - 0.0 1251.0
HKD2_k127_8655850_10 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 606.0
HKD2_k127_8655850_11 citrate synthase K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 604.0
HKD2_k127_8655850_12 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 587.0
HKD2_k127_8655850_13 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 579.0
HKD2_k127_8655850_14 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 572.0
HKD2_k127_8655850_15 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 535.0
HKD2_k127_8655850_16 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 516.0
HKD2_k127_8655850_17 Glucose dehydrogenase C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 531.0
HKD2_k127_8655850_18 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 494.0
HKD2_k127_8655850_19 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007062 490.0
HKD2_k127_8655850_2 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0 1033.0
HKD2_k127_8655850_20 Glutathione S-transferase K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 438.0
HKD2_k127_8655850_21 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 378.0
HKD2_k127_8655850_22 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 363.0
HKD2_k127_8655850_24 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 325.0
HKD2_k127_8655850_25 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 321.0
HKD2_k127_8655850_26 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 283.0
HKD2_k127_8655850_27 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006828 266.0
HKD2_k127_8655850_28 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001925 259.0
HKD2_k127_8655850_29 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 273.0
HKD2_k127_8655850_3 Glycosyl hydrolases family 15 K01178 - 3.2.1.3 2.548e-312 969.0
HKD2_k127_8655850_30 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005197 254.0
HKD2_k127_8655850_31 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002404 246.0
HKD2_k127_8655850_33 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000006421 233.0
HKD2_k127_8655850_35 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000006782 194.0
HKD2_k127_8655850_37 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000000000001338 165.0
HKD2_k127_8655850_38 transcriptional regulator, AraC family - - - 0.000000000000000000000000000000000514 135.0
HKD2_k127_8655850_39 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000000000000004247 108.0
HKD2_k127_8655850_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 5.501e-287 884.0
HKD2_k127_8655850_40 Glutathione S-transferase K11209 - - 0.00000000000000000000004349 98.0
HKD2_k127_8655850_41 - - - - 0.0000000000000000001943 91.0
HKD2_k127_8655850_42 Small Multidrug Resistance protein - - - 0.0000004342 58.0
HKD2_k127_8655850_5 FAD linked oxidase domain protein - - - 1.246e-282 878.0
HKD2_k127_8655850_6 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.595e-276 853.0
HKD2_k127_8655850_7 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 2.393e-264 825.0
HKD2_k127_8655850_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 8.847e-242 758.0
HKD2_k127_8655850_9 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.552e-233 747.0
HKD2_k127_8672532_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1422.0
HKD2_k127_8672532_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1376.0
HKD2_k127_8672532_10 VWA domain containing CoxE-like protein K07161 - - 2.297e-243 754.0
HKD2_k127_8672532_11 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K21323 - 1.14.13.229,1.14.19.48 1.782e-241 766.0
HKD2_k127_8672532_12 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 2.14e-225 713.0
HKD2_k127_8672532_13 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 3.163e-218 681.0
HKD2_k127_8672532_14 Putative serine dehydratase domain - - - 6.759e-213 664.0
HKD2_k127_8672532_15 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 587.0
HKD2_k127_8672532_16 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007538 581.0
HKD2_k127_8672532_17 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 565.0
HKD2_k127_8672532_18 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 542.0
HKD2_k127_8672532_19 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 514.0
HKD2_k127_8672532_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0 1217.0
HKD2_k127_8672532_20 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 513.0
HKD2_k127_8672532_21 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 518.0
HKD2_k127_8672532_22 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 466.0
HKD2_k127_8672532_23 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 467.0
HKD2_k127_8672532_24 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 441.0
HKD2_k127_8672532_25 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 458.0
HKD2_k127_8672532_26 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 453.0
HKD2_k127_8672532_27 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 412.0
HKD2_k127_8672532_28 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 403.0
HKD2_k127_8672532_29 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 382.0
HKD2_k127_8672532_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0 1130.0
HKD2_k127_8672532_30 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 370.0
HKD2_k127_8672532_31 Conserved protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 375.0
HKD2_k127_8672532_32 Protein of unknown function (DUF1007) K00937,K06925 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 333.0
HKD2_k127_8672532_34 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001741 244.0
HKD2_k127_8672532_36 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000000000000005523 232.0
HKD2_k127_8672532_37 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000002171 226.0
HKD2_k127_8672532_38 XdhC and CoxI family - - - 0.0000000000000000000000000000000000000000000000000000000000003227 216.0
HKD2_k127_8672532_39 Acyl-CoA hydrolase K10806 - - 0.00000000000000000000000000000000000000000000000006266 181.0
HKD2_k127_8672532_4 Domain of unknown function (DUF4139) - - - 0.0 1012.0
HKD2_k127_8672532_40 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000001911 191.0
HKD2_k127_8672532_41 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519 - 1.2.5.3 0.0000000000000000000000000000000000000001003 153.0
HKD2_k127_8672532_42 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000000000000000000000002086 150.0
HKD2_k127_8672532_43 transcriptional regulator - - - 0.0000000000000000000866 97.0
HKD2_k127_8672532_5 Probable molybdopterin binding domain K07141 - 2.7.7.76 6.903e-298 932.0
HKD2_k127_8672532_6 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 9.405e-298 919.0
HKD2_k127_8672532_7 acetyl-coa acetyltransferase K00626 - 2.3.1.9 2.184e-291 900.0
HKD2_k127_8672532_8 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.273e-290 906.0
HKD2_k127_8672532_9 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 1.626e-270 838.0
HKD2_k127_8864936_0 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 458.0
HKD2_k127_8864936_1 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 398.0
HKD2_k127_8864936_2 Asp/Glu/Hydantoin racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 306.0
HKD2_k127_8864936_3 Protein of unknown function (DUF3987) - - - 0.0000000000000000000000000000000000000000000000000002828 202.0
HKD2_k127_8870283_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.0 1079.0
HKD2_k127_8870283_1 single-stranded-DNA-specific exonuclease recJ K07462 - - 0.0 1045.0
HKD2_k127_8870283_10 nitrogen compound transport K00759,K02033 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000486 385.0
HKD2_k127_8870283_11 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 372.0
HKD2_k127_8870283_12 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 371.0
HKD2_k127_8870283_13 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000005572 196.0
HKD2_k127_8870283_14 COG1494 Fructose-1,6-bisphosphatase sedoheptulose 1,7-bisphosphatase and related proteins K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000203 134.0
HKD2_k127_8870283_15 Belongs to the ompA family - - - 0.00000000000000000000000000001601 123.0
HKD2_k127_8870283_16 MafB19-like deaminase - - - 0.00000000000000000000000001599 110.0
HKD2_k127_8870283_17 MafB19-like deaminase - - - 0.00000000000000002482 91.0
HKD2_k127_8870283_2 Aminotransferase K14261 - - 1.858e-255 802.0
HKD2_k127_8870283_20 - - - - 0.0000000000002069 83.0
HKD2_k127_8870283_21 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000006023 67.0
HKD2_k127_8870283_3 Resolvase, N terminal domain - - - 5.399e-241 755.0
HKD2_k127_8870283_4 homoserine dehydrogenase K00003 - 1.1.1.3 2.787e-232 724.0
HKD2_k127_8870283_5 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 545.0
HKD2_k127_8870283_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 469.0
HKD2_k127_8870283_7 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 455.0
HKD2_k127_8870283_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 431.0
HKD2_k127_8870283_9 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 399.0
HKD2_k127_8887223_0 Luciferase-like monooxygenase - - - 2.532e-194 609.0
HKD2_k127_8887223_1 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 494.0
HKD2_k127_8887223_2 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 475.0
HKD2_k127_8887223_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 472.0
HKD2_k127_8887223_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 477.0
HKD2_k127_8887223_5 TOBE domain K02052,K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 422.0
HKD2_k127_8887223_6 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000001406 218.0
HKD2_k127_8887223_7 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000003624 133.0
HKD2_k127_8887223_8 Luciferase-like monooxygenase - - - 0.000000000000000000000000000001244 121.0
HKD2_k127_8887223_9 - - - - 0.00000000000000000000000000191 116.0
HKD2_k127_8962040_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1458.0
HKD2_k127_8962040_1 elongator protein 3 miab nifb - - - 3.647e-264 827.0
HKD2_k127_8962040_10 nitrite transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000007681 249.0
HKD2_k127_8962040_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000000000000000007439 215.0
HKD2_k127_8962040_12 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.000000000000000000000000000000000000000002135 163.0
HKD2_k127_8962040_13 - - - - 0.00000000000000000000429 97.0
HKD2_k127_8962040_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 3.488e-207 653.0
HKD2_k127_8962040_3 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 560.0
HKD2_k127_8962040_4 Bacterial extracellular solute-binding protein K02027,K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 558.0
HKD2_k127_8962040_5 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 405.0
HKD2_k127_8962040_6 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 403.0
HKD2_k127_8962040_7 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 336.0
HKD2_k127_8962040_8 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 314.0
HKD2_k127_8962040_9 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005569 277.0
HKD2_k127_8976241_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 5.311e-308 951.0
HKD2_k127_8976241_1 collagen metabolic process - - - 5.56e-299 945.0
HKD2_k127_8976241_10 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 357.0
HKD2_k127_8976241_11 Belongs to the FPP GGPP synthase family K00805,K02523 - 2.5.1.30,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008895 356.0
HKD2_k127_8976241_12 PFAM Binding-protein-dependent transport system inner membrane component K02025,K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 317.0
HKD2_k127_8976241_13 Binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 314.0
HKD2_k127_8976241_14 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 311.0
HKD2_k127_8976241_15 PFAM Binding-protein-dependent transport system inner membrane component K02025,K15771 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006223 278.0
HKD2_k127_8976241_16 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005624 280.0
HKD2_k127_8976241_17 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000047 274.0
HKD2_k127_8976241_18 cobalamin synthesis CobW domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007448 264.0
HKD2_k127_8976241_19 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003227 250.0
HKD2_k127_8976241_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 1.729e-279 871.0
HKD2_k127_8976241_20 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000000000002311 184.0
HKD2_k127_8976241_22 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000009133 131.0
HKD2_k127_8976241_23 Saccharopine dehydrogenase NADP binding domain K00290 - 1.5.1.7 0.0000000000000000000000004113 121.0
HKD2_k127_8976241_24 Domain of unknown function (DUF4396) - - - 0.00000000000002274 81.0
HKD2_k127_8976241_25 Protein of unknown function (DUF3592) - - - 0.00000000000006496 79.0
HKD2_k127_8976241_26 nucleoside 2-deoxyribosyltransferase - - - 0.000000000002505 77.0
HKD2_k127_8976241_27 Putative peptidoglycan binding domain - - - 0.0000000609 64.0
HKD2_k127_8976241_28 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.000005803 58.0
HKD2_k127_8976241_29 Domain of unknown function (DUF4396) - - - 0.00005494 51.0
HKD2_k127_8976241_3 TonB dependent receptor - - - 1.942e-258 819.0
HKD2_k127_8976241_30 RDD family - - - 0.00006956 54.0
HKD2_k127_8976241_4 Bacterial extracellular solute-binding protein - - - 7.598e-219 685.0
HKD2_k127_8976241_5 alcohol dehydrogenase K00001,K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 594.0
HKD2_k127_8976241_6 Catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 586.0
HKD2_k127_8976241_7 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 494.0
HKD2_k127_8976241_8 NAD(P)-binding Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007999 471.0
HKD2_k127_8976241_9 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 409.0
HKD2_k127_8979531_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.0 1162.0
HKD2_k127_8979531_1 Binding-protein-dependent transport system inner membrane component - - - 4.703e-314 968.0
HKD2_k127_8979531_10 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.985e-208 660.0
HKD2_k127_8979531_11 Receptor family ligand binding region - - - 6.395e-203 640.0
HKD2_k127_8979531_12 Belongs to the binding-protein-dependent transport system permease family - - - 2.811e-202 632.0
HKD2_k127_8979531_13 - - - - 1.653e-194 618.0
HKD2_k127_8979531_14 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 605.0
HKD2_k127_8979531_15 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 564.0
HKD2_k127_8979531_16 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 594.0
HKD2_k127_8979531_17 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 562.0
HKD2_k127_8979531_18 HlyD membrane-fusion protein of T1SS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 542.0
HKD2_k127_8979531_19 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 525.0
HKD2_k127_8979531_2 Sulfatase K01133 - 3.1.6.6 1.426e-307 950.0
HKD2_k127_8979531_20 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 515.0
HKD2_k127_8979531_21 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 510.0
HKD2_k127_8979531_22 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 499.0
HKD2_k127_8979531_23 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 490.0
HKD2_k127_8979531_24 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 475.0
HKD2_k127_8979531_25 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 451.0
HKD2_k127_8979531_26 Major Facilitator Superfamily K08224 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 454.0
HKD2_k127_8979531_27 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 427.0
HKD2_k127_8979531_28 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 364.0
HKD2_k127_8979531_29 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 316.0
HKD2_k127_8979531_3 Major Facilitator Superfamily - - - 1.005e-276 856.0
HKD2_k127_8979531_30 PFAM Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 305.0
HKD2_k127_8979531_31 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 303.0
HKD2_k127_8979531_32 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 294.0
HKD2_k127_8979531_33 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 301.0
HKD2_k127_8979531_34 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006049 278.0
HKD2_k127_8979531_35 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004008 266.0
HKD2_k127_8979531_36 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006016 262.0
HKD2_k127_8979531_37 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001275 239.0
HKD2_k127_8979531_38 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001755 235.0
HKD2_k127_8979531_39 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000000000000001538 174.0
HKD2_k127_8979531_4 MmgE/PrpD family - - - 3.852e-253 785.0
HKD2_k127_8979531_40 Cupin domain - - - 0.00000000000000000000000000000000000000000000001592 183.0
HKD2_k127_8979531_41 Redoxin - - - 0.000000000000000000000000000000000002889 148.0
HKD2_k127_8979531_42 Periplasmic binding protein - - - 0.00000000000000000000000000003763 136.0
HKD2_k127_8979531_43 - - - - 0.0000000000000000000000005996 121.0
HKD2_k127_8979531_5 III protein, CoA-transferase family - - - 2.112e-242 750.0
HKD2_k127_8979531_6 III protein, CoA-transferase family - - - 1.241e-233 727.0
HKD2_k127_8979531_7 COG1960 Acyl-CoA dehydrogenases - - - 3.807e-229 713.0
HKD2_k127_8979531_8 4-hydroxyphenylacetate 3-hydroxylase K14534 - 4.2.1.120,5.3.3.3 6.398e-217 681.0
HKD2_k127_8979531_9 Periplasmic binding protein K01999 - - 5.499e-215 676.0
HKD2_k127_8986595_0 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 519.0
HKD2_k127_8986595_1 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 404.0
HKD2_k127_8986595_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 406.0
HKD2_k127_8986595_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 373.0
HKD2_k127_8986595_4 deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008406 340.0
HKD2_k127_8986595_5 - - - - 0.00000000000000000000000000000000000000000000004202 174.0
HKD2_k127_8986595_6 - - - - 0.00000000000000000005439 93.0
HKD2_k127_8986595_7 Ferredoxin - - - 0.0000009226 53.0
HKD2_k127_9119290_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1440.0
HKD2_k127_9119290_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 589.0
HKD2_k127_9119290_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 516.0
HKD2_k127_9119290_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 513.0
HKD2_k127_9119290_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 491.0
HKD2_k127_9119290_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 303.0
HKD2_k127_9119290_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000000000000000000000000000007814 223.0
HKD2_k127_9119290_8 Uncharacterised protein family (UPF0093) K08973 - - 0.0000000000000000000000000000000000000000001425 164.0
HKD2_k127_9119290_9 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000004458 63.0
HKD2_k127_9127935_0 Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide K00376 - 1.7.2.4 0.0 1032.0
HKD2_k127_9127935_1 FMN_bind K19339 - - 1.915e-292 917.0
HKD2_k127_9127935_10 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 330.0
HKD2_k127_9127935_11 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 307.0
HKD2_k127_9127935_12 ABC transporter K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 328.0
HKD2_k127_9127935_13 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 297.0
HKD2_k127_9127935_14 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992,K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007571 297.0
HKD2_k127_9127935_15 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003103 282.0
HKD2_k127_9127935_16 phosphonoacetaldehyde hydrolase activity K01087,K01194,K01838,K05342 GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000003379 271.0
HKD2_k127_9127935_17 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000001811 233.0
HKD2_k127_9127935_18 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000004654 229.0
HKD2_k127_9127935_19 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000001336 220.0
HKD2_k127_9127935_2 PFAM ABC transporter K02471 - - 6.057e-205 656.0
HKD2_k127_9127935_20 NosL K19342 - - 0.00000000000000000000000000000000000000000000000000002633 205.0
HKD2_k127_9127935_21 DsrE/DsrF-like family K06039 - - 0.000000000000000000000000000000000000000000000000002586 188.0
HKD2_k127_9127935_23 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000001334 163.0
HKD2_k127_9127935_24 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000001372 123.0
HKD2_k127_9127935_25 Cytochrome c2 K08738 - - 0.0000000000000000000000000004052 128.0
HKD2_k127_9127935_26 COG0694 Thioredoxin-like proteins and domains - - - 0.000000000000000000000000002994 119.0
HKD2_k127_9127935_27 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.00000000000000000000000002543 119.0
HKD2_k127_9127935_28 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000008993 115.0
HKD2_k127_9127935_3 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 501.0
HKD2_k127_9127935_4 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 484.0
HKD2_k127_9127935_5 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 459.0
HKD2_k127_9127935_6 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 462.0
HKD2_k127_9127935_7 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 424.0
HKD2_k127_9127935_8 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 399.0
HKD2_k127_9127935_9 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 330.0
HKD2_k127_9143118_0 FAD dependent oxidoreductase - - - 1.496e-228 714.0
HKD2_k127_9143118_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.217e-217 691.0
HKD2_k127_9143118_10 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000001569 174.0
HKD2_k127_9143118_2 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 548.0
HKD2_k127_9143118_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 538.0
HKD2_k127_9143118_4 Belongs to the enoyl-CoA hydratase isomerase family K08299,K16426 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 399.0
HKD2_k127_9143118_5 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 393.0
HKD2_k127_9143118_6 COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 394.0
HKD2_k127_9143118_7 cyclic nucleotide binding K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 395.0
HKD2_k127_9143118_8 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002745 260.0
HKD2_k127_9143118_9 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000002775 176.0
HKD2_k127_9159569_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 8.334e-229 714.0
HKD2_k127_9159569_1 amidohydrolase - - - 2.897e-215 671.0
HKD2_k127_9159569_2 Winged helix DNA-binding domain K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 597.0
HKD2_k127_9159569_3 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 497.0
HKD2_k127_9159569_4 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 444.0
HKD2_k127_9159569_5 Putative PD-(D/E)XK phosphodiesterase (DUF2161) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 349.0
HKD2_k127_9159569_6 monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002737 270.0
HKD2_k127_9159569_7 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004279 271.0
HKD2_k127_9159569_8 2-Nitropropane dioxygenase - - - 0.0000000000000000000000000000000000000000001375 172.0
HKD2_k127_9159569_9 - - - - 0.0000000000000000000000000000000000000000001489 177.0
HKD2_k127_920986_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1187.0
HKD2_k127_920986_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.049e-262 817.0
HKD2_k127_920986_10 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 530.0
HKD2_k127_920986_11 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 496.0
HKD2_k127_920986_12 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 480.0
HKD2_k127_920986_13 branched-chain amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 421.0
HKD2_k127_920986_14 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 387.0
HKD2_k127_920986_15 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 386.0
HKD2_k127_920986_16 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 366.0
HKD2_k127_920986_17 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 325.0
HKD2_k127_920986_18 transcriptional regulator, MerR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 313.0
HKD2_k127_920986_19 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 325.0
HKD2_k127_920986_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 1.087e-261 811.0
HKD2_k127_920986_20 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 304.0
HKD2_k127_920986_21 Uncharacterized ACR, COG1399 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000125 272.0
HKD2_k127_920986_22 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000004789 257.0
HKD2_k127_920986_23 COG0698 Ribose 5-phosphate isomerase RpiB K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000005443 256.0
HKD2_k127_920986_24 regulatory protein K13529 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000006441 259.0
HKD2_k127_920986_25 Ubiquinol-cytochrome C chaperone K17662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001915 260.0
HKD2_k127_920986_26 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004304 261.0
HKD2_k127_920986_27 COG2913 Small protein A (tmRNA-binding) - - - 0.00000000000000000000000000000000000000000000000000000000000000001488 233.0
HKD2_k127_920986_28 - - - - 0.0000000000000000000000000000000000000000000000000000000001024 211.0
HKD2_k127_920986_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 5.328e-227 706.0
HKD2_k127_920986_30 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000008353 150.0
HKD2_k127_920986_31 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.000000000000000000000000102 108.0
HKD2_k127_920986_32 - - - - 0.00000000000000000000001278 101.0
HKD2_k127_920986_33 - - - - 0.000000000000000000000327 99.0
HKD2_k127_920986_34 Arm DNA-binding domain - - - 0.00000000000000003491 87.0
HKD2_k127_920986_4 Major Facilitator Superfamily - - - 2.719e-215 675.0
HKD2_k127_920986_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 6.752e-202 641.0
HKD2_k127_920986_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 605.0
HKD2_k127_920986_7 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 593.0
HKD2_k127_920986_8 Sugar (and other) transporter K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 582.0
HKD2_k127_920986_9 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 538.0
HKD2_k127_9223062_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.285e-298 920.0
HKD2_k127_9223062_1 COG0457 FOG TPR repeat - - - 1.166e-291 902.0
HKD2_k127_9223062_10 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 383.0
HKD2_k127_9223062_11 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009125 393.0
HKD2_k127_9223062_12 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 370.0
HKD2_k127_9223062_13 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 351.0
HKD2_k127_9223062_14 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 328.0
HKD2_k127_9223062_16 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006632 277.0
HKD2_k127_9223062_17 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000001916 267.0
HKD2_k127_9223062_18 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003273 259.0
HKD2_k127_9223062_19 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000001855 175.0
HKD2_k127_9223062_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 3.984e-227 710.0
HKD2_k127_9223062_20 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000000000000007005 169.0
HKD2_k127_9223062_21 - - - - 0.00000000000000000000000000000000000000000000114 180.0
HKD2_k127_9223062_22 Cell division protein K03591,K03749 - - 0.000000000000000000000000000003527 132.0
HKD2_k127_9223062_23 Amino-transferase class IV K00824 - 2.6.1.21 0.00000000000000000000006344 98.0
HKD2_k127_9223062_25 Resolvase, N terminal domain - - - 0.000000000003366 69.0
HKD2_k127_9223062_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 3.63e-208 657.0
HKD2_k127_9223062_4 DNA polymerase III subunit delta K02341 - 2.7.7.7 1.332e-207 649.0
HKD2_k127_9223062_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 3.69e-200 631.0
HKD2_k127_9223062_6 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 480.0
HKD2_k127_9223062_7 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 438.0
HKD2_k127_9223062_8 Lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 439.0
HKD2_k127_9223062_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 415.0
HKD2_k127_9234862_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0 1540.0
HKD2_k127_9234862_1 Amidohydrolase family - - - 0.0 1023.0
HKD2_k127_9234862_10 peptidyl-tyrosine modification K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 489.0
HKD2_k127_9234862_11 Phosphoesterase family K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 499.0
HKD2_k127_9234862_12 Beta-xylanase K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 474.0
HKD2_k127_9234862_13 PFAM amidohydrolase 2 K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 432.0
HKD2_k127_9234862_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 426.0
HKD2_k127_9234862_15 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 424.0
HKD2_k127_9234862_16 Nad-dependent epimerase dehydratase K08678 - 4.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 421.0
HKD2_k127_9234862_17 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 392.0
HKD2_k127_9234862_18 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 408.0
HKD2_k127_9234862_19 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 391.0
HKD2_k127_9234862_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 1.88e-303 937.0
HKD2_k127_9234862_20 imidazolonepropionase activity K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 382.0
HKD2_k127_9234862_21 PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 378.0
HKD2_k127_9234862_22 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 353.0
HKD2_k127_9234862_23 Putative 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 342.0
HKD2_k127_9234862_24 Short-chain dehydrogenase reductase (SDR) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 342.0
HKD2_k127_9234862_25 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000942 316.0
HKD2_k127_9234862_26 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 301.0
HKD2_k127_9234862_27 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 292.0
HKD2_k127_9234862_28 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004695 274.0
HKD2_k127_9234862_29 IMP dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000001668 209.0
HKD2_k127_9234862_3 Pyridoxal-dependent decarboxylase conserved domain - - - 4.905e-195 619.0
HKD2_k127_9234862_31 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000165 182.0
HKD2_k127_9234862_32 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000002121 179.0
HKD2_k127_9234862_33 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000000000000000000000000002525 190.0
HKD2_k127_9234862_34 Cytochrome c K17230 - - 0.00000000000000000000000000000000000000000000004088 177.0
HKD2_k127_9234862_35 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000000000000000000000000000004851 182.0
HKD2_k127_9234862_36 AraC family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000133 178.0
HKD2_k127_9234862_37 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.000000000000000000000000000000000000000000004257 173.0
HKD2_k127_9234862_38 AraC family transcriptional regulator - - - 0.00000000000000000000000000000000000000000005781 173.0
HKD2_k127_9234862_39 IMP dehydrogenase activity - - - 0.000000000000000000000000000000000000000006614 162.0
HKD2_k127_9234862_4 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 604.0
HKD2_k127_9234862_40 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000435 167.0
HKD2_k127_9234862_41 - - - - 0.00000000000000000000000000000000655 136.0
HKD2_k127_9234862_42 Pyrroloquinoline quinone biosynthesis protein D K06138 - - 0.000000000000000000000000009582 111.0
HKD2_k127_9234862_44 Macrocin-O-methyltransferase (TylF) - - - 0.000000000000342 81.0
HKD2_k127_9234862_45 Peptidoglycan-binding domain 1 protein - - - 0.00000000001573 76.0
HKD2_k127_9234862_47 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.000000005044 61.0
HKD2_k127_9234862_5 NAD-dependent epimerase dehydratase K01784,K08678,K12454,K17947 - 4.1.1.35,5.1.3.10,5.1.3.2,5.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 592.0
HKD2_k127_9234862_51 - - - - 0.0002234 53.0
HKD2_k127_9234862_52 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0003168 53.0
HKD2_k127_9234862_6 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 586.0
HKD2_k127_9234862_7 Cyclohexanecarboxylate-CoA ligase K04116,K12507 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 590.0
HKD2_k127_9234862_8 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 573.0
HKD2_k127_9234862_9 transferase activity, transferring glycosyl groups K19003 - 2.4.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 543.0
HKD2_k127_9243193_0 Iron-containing alcohol dehydrogenase - - - 4.029e-220 686.0
HKD2_k127_9243193_1 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 488.0
HKD2_k127_9243193_11 DDE superfamily endonuclease - - - 0.000134 44.0
HKD2_k127_9243193_2 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 430.0
HKD2_k127_9243193_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 414.0
HKD2_k127_9243193_4 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 331.0
HKD2_k127_9243193_5 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000001564 190.0
HKD2_k127_9243193_6 YHS domain protein - - - 0.000000000000000000000000000000217 130.0
HKD2_k127_9243193_7 - - - - 0.0000000000000000000000000729 115.0
HKD2_k127_9243193_9 Belongs to the ABC transporter superfamily K02031,K02032,K13896 - - 0.00000000002488 66.0
HKD2_k127_9253617_0 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 7.153e-281 867.0
HKD2_k127_9253617_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 521.0
HKD2_k127_9253617_2 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 530.0
HKD2_k127_9253617_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 480.0
HKD2_k127_9253617_4 PFAM Taurine catabolism dioxygenase TauD TfdA K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000005467 261.0
HKD2_k127_9253617_5 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000002265 203.0
HKD2_k127_9253617_6 Thiolase, C-terminal domain - - - 0.00000000000000000007041 93.0
HKD2_k127_9264110_0 COG3264 Small-conductance mechanosensitive channel K05802 - - 1.166e-320 1005.0
HKD2_k127_9264110_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 2.494e-318 982.0
HKD2_k127_9264110_10 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 524.0
HKD2_k127_9264110_11 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 476.0
HKD2_k127_9264110_12 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 406.0
HKD2_k127_9264110_13 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 407.0
HKD2_k127_9264110_14 Ca2 -binding protein (EF-Hand superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 405.0
HKD2_k127_9264110_15 Glutathione S-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 366.0
HKD2_k127_9264110_16 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 369.0
HKD2_k127_9264110_17 COG0500 SAM-dependent methyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 366.0
HKD2_k127_9264110_18 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 365.0
HKD2_k127_9264110_19 Protein of unknown function (DUF1499) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 329.0
HKD2_k127_9264110_2 homoserine dehydrogenase - - - 3.559e-282 869.0
HKD2_k127_9264110_20 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 316.0
HKD2_k127_9264110_21 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 334.0
HKD2_k127_9264110_22 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 316.0
HKD2_k127_9264110_23 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 287.0
HKD2_k127_9264110_25 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003522 272.0
HKD2_k127_9264110_27 Predicted periplasmic protein (DUF2092) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008958 260.0
HKD2_k127_9264110_28 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005139 232.0
HKD2_k127_9264110_29 fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000001333 234.0
HKD2_k127_9264110_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 1.076e-242 758.0
HKD2_k127_9264110_30 Globin - - - 0.0000000000000000000000000000000000000000000000000000001092 199.0
HKD2_k127_9264110_31 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000003812 179.0
HKD2_k127_9264110_32 - - - - 0.0000000000000000000000000000000000000001342 164.0
HKD2_k127_9264110_33 - - - - 0.00000000000000000000000000000000000000034 159.0
HKD2_k127_9264110_34 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000000000002377 148.0
HKD2_k127_9264110_35 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000003774 133.0
HKD2_k127_9264110_36 - - - - 0.000000000000000000000000001094 119.0
HKD2_k127_9264110_38 - - - - 0.00000000000000000000379 96.0
HKD2_k127_9264110_39 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000000000002392 84.0
HKD2_k127_9264110_4 His Kinase A (phosphoacceptor) domain - - - 6.442e-227 711.0
HKD2_k127_9264110_40 - - - - 0.00000000000000005249 82.0
HKD2_k127_9264110_5 COG0526, thiol-disulfide isomerase and thioredoxins - - - 1.268e-209 661.0
HKD2_k127_9264110_6 Belongs to the LDH2 MDH2 oxidoreductase family - - - 1.821e-205 652.0
HKD2_k127_9264110_7 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 608.0
HKD2_k127_9264110_8 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 579.0
HKD2_k127_9264110_9 Alpha beta hydrolase K18092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 543.0
HKD2_k127_9283126_0 metal-dependent hydrolase involved in phosphonate metabolism K06162 - 3.6.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 596.0
HKD2_k127_9283126_1 Phosphonate ABC transporter K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 511.0
HKD2_k127_9283126_10 Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) K05774 - 2.7.4.23 0.00000000000000000000000000000000000000000002748 171.0
HKD2_k127_9283126_11 (ABC transporter), ATP-binding K05780 - 2.7.8.37 0.0000000000000000000000000000000000000007655 149.0
HKD2_k127_9283126_12 Transposase DDE domain - - - 0.000000000007062 65.0
HKD2_k127_9283126_13 Sodium Bile acid symporter family - - - 0.00000001058 66.0
HKD2_k127_9283126_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 450.0
HKD2_k127_9283126_3 Phosphonate ABC transporter K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 444.0
HKD2_k127_9283126_4 Sodium Bile acid symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 403.0
HKD2_k127_9283126_5 COG3639 ABC-type phosphate phosphonate transport system, permease component K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 406.0
HKD2_k127_9283126_6 Protein of unknown function (DUF1045) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 353.0
HKD2_k127_9283126_7 Creatinine amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000001115 217.0
HKD2_k127_9283126_8 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000000000000000000000000000007589 195.0
HKD2_k127_9283126_9 - - - - 0.00000000000000000000000000000000000000000000000005177 196.0
HKD2_k127_9321249_0 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 526.0
HKD2_k127_9321249_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 420.0
HKD2_k127_9321249_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 322.0
HKD2_k127_9321249_3 YXWGXW repeat (2 copies) - - - 0.0000000000000000000000006754 109.0
HKD2_k127_9321249_5 - - - - 0.0000000000000000000003434 105.0
HKD2_k127_9321249_6 Flavodoxin-like fold K00355 - 1.6.5.2 0.00006521 55.0
HKD2_k127_9350711_0 - - - - 1.389e-197 619.0
HKD2_k127_9350711_1 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 503.0
HKD2_k127_9350711_2 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 470.0
HKD2_k127_9350711_3 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000000000000000000000002463 171.0
HKD2_k127_9350711_4 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000000001538 174.0
HKD2_k127_9350711_5 NUDIX domain - - - 0.0000000000000000000003538 104.0
HKD2_k127_9350711_7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000003397 75.0
HKD2_k127_9358602_0 COG0841 Cation multidrug efflux pump K18138 - - 0.0 1702.0
HKD2_k127_9358602_1 Adenylate cyclase K01768 - 4.6.1.1 2.755e-305 949.0
HKD2_k127_9358602_10 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 504.0
HKD2_k127_9358602_11 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 503.0
HKD2_k127_9358602_12 the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 435.0
HKD2_k127_9358602_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 422.0
HKD2_k127_9358602_14 Glycosyl hydrolases family 25 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 373.0
HKD2_k127_9358602_15 COG1994 Zn-dependent proteases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 320.0
HKD2_k127_9358602_16 Transcriptional regulator K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 315.0
HKD2_k127_9358602_17 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004169 267.0
HKD2_k127_9358602_18 of the double-stranded beta helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006832 264.0
HKD2_k127_9358602_19 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005631 258.0
HKD2_k127_9358602_2 Belongs to the TPP enzyme family - - - 1.542e-275 856.0
HKD2_k127_9358602_20 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007749 278.0
HKD2_k127_9358602_21 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004494 228.0
HKD2_k127_9358602_22 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000000000000000000000000000000000000000000000009765 229.0
HKD2_k127_9358602_23 - - - - 0.000000000000000000000000000000000000000000000000000000000000002296 239.0
HKD2_k127_9358602_24 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000004329 222.0
HKD2_k127_9358602_26 Cold shock K03704 - - 0.0000000000000000000000000000000002693 131.0
HKD2_k127_9358602_27 Domain of unknown function (DUF4437) - - - 0.00000000000000000000000001089 115.0
HKD2_k127_9358602_28 - - - - 0.00000000000000000000000002184 117.0
HKD2_k127_9358602_29 YXWGXW repeat (2 copies) - - - 0.000000000000000000000008283 104.0
HKD2_k127_9358602_3 CoA-transferase family III - - - 6.765e-231 722.0
HKD2_k127_9358602_30 - - - - 0.0000000000000000006433 93.0
HKD2_k127_9358602_31 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000001424 89.0
HKD2_k127_9358602_32 Protein tyrosine kinase - - - 0.00000001314 63.0
HKD2_k127_9358602_4 belongs to the bacterial solute-binding protein 3 family K02030 - - 3.597e-220 699.0
HKD2_k127_9358602_5 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 6.15e-212 668.0
HKD2_k127_9358602_6 Belongs to the amidase family K01426 - 3.5.1.4 6.356e-212 667.0
HKD2_k127_9358602_7 acetyl-coa acetyltransferase - - - 4.668e-202 637.0
HKD2_k127_9358602_8 Uncharacterised MFS-type transporter YbfB - - - 5.296e-194 621.0
HKD2_k127_9358602_9 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 532.0
HKD2_k127_9376219_0 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 0.0 1113.0
HKD2_k127_9376219_1 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 577.0
HKD2_k127_9376219_10 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000000000000000000000000000000000003367 216.0
HKD2_k127_9376219_11 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000003248 157.0
HKD2_k127_9376219_12 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000003493 122.0
HKD2_k127_9376219_13 Belongs to the ompA family - - - 0.000000000007478 72.0
HKD2_k127_9376219_14 Bacterial transferase hexapeptide (six repeats) - - - 0.0000001244 57.0
HKD2_k127_9376219_2 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 556.0
HKD2_k127_9376219_3 fatty acid alpha-oxidation K12261 GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 520.0
HKD2_k127_9376219_4 Belongs to the enoyl-CoA hydratase isomerase family K08299 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 489.0
HKD2_k127_9376219_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 466.0
HKD2_k127_9376219_6 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 449.0
HKD2_k127_9376219_7 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 383.0
HKD2_k127_9376219_8 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 336.0
HKD2_k127_9376219_9 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000014 241.0
HKD2_k127_9463892_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.0 1086.0
HKD2_k127_9463892_1 Glycosyl hydrolases family 15 - - - 0.0 1054.0
HKD2_k127_9463892_10 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 475.0
HKD2_k127_9463892_11 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 440.0
HKD2_k127_9463892_12 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 452.0
HKD2_k127_9463892_13 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 421.0
HKD2_k127_9463892_14 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004988 408.0
HKD2_k127_9463892_15 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 394.0
HKD2_k127_9463892_16 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 364.0
HKD2_k127_9463892_17 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 357.0
HKD2_k127_9463892_18 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 344.0
HKD2_k127_9463892_19 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000254 266.0
HKD2_k127_9463892_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.917e-320 990.0
HKD2_k127_9463892_20 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000000000000000000000000000004272 231.0
HKD2_k127_9463892_21 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000622 198.0
HKD2_k127_9463892_22 PFAM Dimethylmenaquinone methyltransferase - - - 0.000000000000000000000000000000000009867 149.0
HKD2_k127_9463892_23 CHAP domain - - - 0.0000000000000000000000000000000001344 150.0
HKD2_k127_9463892_24 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000006544 130.0
HKD2_k127_9463892_25 FeoA K04758 - - 0.00000000000000000000000000226 117.0
HKD2_k127_9463892_26 integral membrane protein - - - 0.000000000000000000000003687 109.0
HKD2_k127_9463892_28 electron transfer activity K08738 - - 0.00000000000000000002548 106.0
HKD2_k127_9463892_3 Amidase - - - 1.09e-267 828.0
HKD2_k127_9463892_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 2.001e-247 777.0
HKD2_k127_9463892_5 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 1.142e-223 718.0
HKD2_k127_9463892_6 Aminotransferase class-V - - - 9.574e-223 693.0
HKD2_k127_9463892_7 Serine aminopeptidase, S33 - - - 9.881e-196 629.0
HKD2_k127_9463892_8 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 596.0
HKD2_k127_9463892_9 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 540.0
HKD2_k127_9519700_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0 1036.0
HKD2_k127_9519700_1 carboxylic acid catabolic process - - - 4.132e-237 734.0
HKD2_k127_9519700_2 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 4.311e-219 682.0
HKD2_k127_9519700_3 Prokaryotic glutathione synthetase, ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 323.0
HKD2_k127_9519700_4 HlyD membrane-fusion protein of T1SS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006983 277.0
HKD2_k127_9563986_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.122e-301 939.0
HKD2_k127_9563986_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 1.289e-285 881.0
HKD2_k127_9563986_10 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 394.0
HKD2_k127_9563986_13 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000002948 264.0
HKD2_k127_9563986_14 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000001338 241.0
HKD2_k127_9563986_15 COG2867 Oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000000000000000000000000000000000001981 229.0
HKD2_k127_9563986_16 Septum formation initiator - - - 0.0000000000000000000000000000000000000000000000000001482 186.0
HKD2_k127_9563986_17 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000009825 177.0
HKD2_k127_9563986_18 transposase activity - - - 0.0000000000000000000000000000000001494 147.0
HKD2_k127_9563986_19 Cytochrome C assembly protein - - - 0.00000000000000000000000000002812 124.0
HKD2_k127_9563986_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.077e-249 773.0
HKD2_k127_9563986_20 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000004276 110.0
HKD2_k127_9563986_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 4.485e-204 662.0
HKD2_k127_9563986_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 1.914e-199 624.0
HKD2_k127_9563986_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 601.0
HKD2_k127_9563986_6 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 562.0
HKD2_k127_9563986_7 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009082 484.0
HKD2_k127_9563986_8 AraC-like ligand binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 437.0
HKD2_k127_9563986_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 438.0
HKD2_k127_9642049_0 FAD dependent oxidoreductase - - - 0.0 1554.0
HKD2_k127_9642049_1 Binding-protein-dependent transport system inner membrane component K02011 - - 4.827e-294 927.0
HKD2_k127_9642049_10 PrpF protein - - - 1.762e-202 636.0
HKD2_k127_9642049_11 Transposase - - - 1.275e-196 618.0
HKD2_k127_9642049_12 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.378e-196 631.0
HKD2_k127_9642049_13 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 600.0
HKD2_k127_9642049_14 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 591.0
HKD2_k127_9642049_15 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 484.0
HKD2_k127_9642049_16 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 467.0
HKD2_k127_9642049_17 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 438.0
HKD2_k127_9642049_18 Alpha/beta hydrolase family K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 286.0
HKD2_k127_9642049_19 Ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001922 279.0
HKD2_k127_9642049_2 Aldehyde dehydrogenase family - - - 1.969e-290 897.0
HKD2_k127_9642049_20 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005864 260.0
HKD2_k127_9642049_21 Alpha/beta hydrolase family K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000003177 253.0
HKD2_k127_9642049_22 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000001794 231.0
HKD2_k127_9642049_23 Rhodanese-like domain - - - 0.00000000000000000000000000000000000000000000000000000000001064 215.0
HKD2_k127_9642049_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000000000002496 203.0
HKD2_k127_9642049_25 - - - - 0.000000000000000000000000000000000000000001502 158.0
HKD2_k127_9642049_26 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000007689 154.0
HKD2_k127_9642049_27 - - - - 0.000000000000000000000002585 104.0
HKD2_k127_9642049_28 Protein of unknown function (DUF1622) - - - 0.000000000000000000000003846 119.0
HKD2_k127_9642049_29 SnoaL-like polyketide cyclase K15945 - - 0.000000000003848 73.0
HKD2_k127_9642049_3 Flavin-binding monooxygenase-like - - - 1.208e-283 875.0
HKD2_k127_9642049_4 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 6.797e-276 852.0
HKD2_k127_9642049_5 Na+/Pi-cotransporter K03324 - - 4.856e-268 834.0
HKD2_k127_9642049_6 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 4.119e-243 754.0
HKD2_k127_9642049_7 Iron-containing alcohol dehydrogenase - - - 6.108e-226 704.0
HKD2_k127_9642049_8 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 2.303e-213 666.0
HKD2_k127_9642049_9 Bacterial extracellular solute-binding protein K02012 - - 3.099e-203 635.0
HKD2_k127_9645752_0 belongs to the aldehyde dehydrogenase family K09472,K12254 - 1.2.1.54,1.2.1.99 2.063e-313 962.0
HKD2_k127_9645752_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 326.0
HKD2_k127_9645752_2 PFAM Rieske 2Fe-2S domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005253 251.0
HKD2_k127_9645752_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000004857 146.0
HKD2_k127_9645752_4 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000005742 80.0
HKD2_k127_9660782_0 GntP family permease K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 589.0
HKD2_k127_9660782_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 582.0
HKD2_k127_9660782_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000003829 149.0
HKD2_k127_9660782_11 Short-chain dehydrogenase reductase (SDR) - - - 0.000000000000000000000000000001002 124.0
HKD2_k127_9660782_12 PFAM FAD linked oxidase domain protein - - - 0.0000000000003201 75.0
HKD2_k127_9660782_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 524.0
HKD2_k127_9660782_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 474.0
HKD2_k127_9660782_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 361.0
HKD2_k127_9660782_5 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 361.0
HKD2_k127_9660782_6 NADPH quinone reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 328.0
HKD2_k127_9660782_7 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004996 255.0
HKD2_k127_9660782_8 Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate K09018 GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.14.99.46 0.00000000000000000000000000000000000000000000000000000004984 196.0
HKD2_k127_9661011_0 Belongs to the peptidase M17 family K01255 - 3.4.11.1 1.052e-221 696.0
HKD2_k127_9661011_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 576.0
HKD2_k127_9661011_10 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000001803 162.0
HKD2_k127_9661011_11 CoA-transferase family III - - - 0.00000000000000000000000000000002023 126.0
HKD2_k127_9661011_2 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 402.0
HKD2_k127_9661011_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 361.0
HKD2_k127_9661011_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 330.0
HKD2_k127_9661011_5 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 318.0
HKD2_k127_9661011_6 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001531 260.0
HKD2_k127_9661011_7 energy transducer activity K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000009035 237.0
HKD2_k127_9661011_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000003871 227.0
HKD2_k127_9661011_9 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000002 184.0
HKD2_k127_9685101_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1993.0
HKD2_k127_9685101_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.0 1091.0
HKD2_k127_9685101_10 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 548.0
HKD2_k127_9685101_11 Tripartite tricarboxylate transporter family receptor K07795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 536.0
HKD2_k127_9685101_12 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 534.0
HKD2_k127_9685101_13 Lysophospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 534.0
HKD2_k127_9685101_14 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 475.0
HKD2_k127_9685101_15 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 439.0
HKD2_k127_9685101_16 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003953 436.0
HKD2_k127_9685101_17 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 450.0
HKD2_k127_9685101_18 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 402.0
HKD2_k127_9685101_19 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 364.0
HKD2_k127_9685101_2 Belongs to the TPP enzyme family K01577,K01652 - 2.2.1.6,4.1.1.8 0.0 1031.0
HKD2_k127_9685101_20 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 353.0
HKD2_k127_9685101_21 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 326.0
HKD2_k127_9685101_22 membrane protein involved in D-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 331.0
HKD2_k127_9685101_23 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 302.0
HKD2_k127_9685101_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007722 236.0
HKD2_k127_9685101_26 oxidation-reduction process K04782 - 4.2.99.21 0.000000000000000000000000000000000000000000000000000000003911 202.0
HKD2_k127_9685101_27 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000000000000000000000000005455 201.0
HKD2_k127_9685101_28 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000001131 183.0
HKD2_k127_9685101_29 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000263 181.0
HKD2_k127_9685101_3 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 5.648e-296 915.0
HKD2_k127_9685101_30 tail collar domain protein - - - 0.00000000000000000000000000000000000000000005457 169.0
HKD2_k127_9685101_32 Phage Tail Collar Domain - - - 0.0000000000000000000000000001008 127.0
HKD2_k127_9685101_33 Transposase DDE domain - - - 0.00000000000000000000001424 100.0
HKD2_k127_9685101_35 - - - - 0.0000000000000000000001261 102.0
HKD2_k127_9685101_36 Zinc-finger domain - - - 0.0000000000000000009924 91.0
HKD2_k127_9685101_37 ABC transporter transmembrane region K06147 - - 0.000000000000006969 89.0
HKD2_k127_9685101_39 COG3210 Large exoproteins involved in heme utilization or adhesion K15125 - - 0.00000000000009667 84.0
HKD2_k127_9685101_4 COG0457 FOG TPR repeat - - - 2.234e-291 910.0
HKD2_k127_9685101_40 Chaperone of endosialidase - - - 0.0000000000006278 79.0
HKD2_k127_9685101_41 - - - - 0.00000000148 63.0
HKD2_k127_9685101_42 - - - - 0.00000003261 65.0
HKD2_k127_9685101_43 - - - - 0.00005296 56.0
HKD2_k127_9685101_44 - - - - 0.00007233 49.0
HKD2_k127_9685101_45 COG3209 Rhs family protein - - - 0.00009039 52.0
HKD2_k127_9685101_5 Tripartite tricarboxylate transporter TctA family K07793 - - 5.87e-263 816.0
HKD2_k127_9685101_6 Urate oxidase N-terminal - - - 5.668e-234 726.0
HKD2_k127_9685101_7 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 4.277e-232 735.0
HKD2_k127_9685101_8 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 9.899e-204 640.0
HKD2_k127_9685101_9 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 573.0
HKD2_k127_9751912_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 8.61e-225 700.0
HKD2_k127_9751912_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 593.0
HKD2_k127_9751912_2 YHYH protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008655 278.0
HKD2_k127_9751912_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000008596 78.0
HKD2_k127_9810226_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.0 1223.0
HKD2_k127_9810226_1 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 4.491e-291 900.0
HKD2_k127_9810226_10 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004636 250.0
HKD2_k127_9810226_11 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000000000000003346 232.0
HKD2_k127_9810226_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000000000002281 202.0
HKD2_k127_9810226_13 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000001133 129.0
HKD2_k127_9810226_14 Response regulator receiver - - - 0.00000000000000000008609 94.0
HKD2_k127_9810226_2 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 5.711e-243 754.0
HKD2_k127_9810226_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.151e-226 712.0
HKD2_k127_9810226_4 FAD binding domain - - - 3.45e-213 670.0
HKD2_k127_9810226_5 Conserved region in glutamate synthase - - - 1.145e-208 651.0
HKD2_k127_9810226_6 COG0841 Cation multidrug efflux pump K03296 - - 1.563e-199 641.0
HKD2_k127_9810226_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005617 535.0
HKD2_k127_9810226_8 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 502.0
HKD2_k127_9857062_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2903.0
HKD2_k127_9857062_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1756.0
HKD2_k127_9857062_10 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit K16319,K18074 - 1.14.12.1,1.14.12.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 514.0
HKD2_k127_9857062_11 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 434.0
HKD2_k127_9857062_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 406.0
HKD2_k127_9857062_13 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 381.0
HKD2_k127_9857062_14 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 377.0
HKD2_k127_9857062_15 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 362.0
HKD2_k127_9857062_16 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 318.0
HKD2_k127_9857062_17 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 312.0
HKD2_k127_9857062_18 Dehydroquinase class II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005906 253.0
HKD2_k127_9857062_19 Methylmuconolactone methyl-isomerase - - - 0.00000000000000000000000000000000000000000000000000000001041 200.0
HKD2_k127_9857062_2 ATP-dependent helicase K03579 - 3.6.4.13 0.0 1380.0
HKD2_k127_9857062_20 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000000000000002758 198.0
HKD2_k127_9857062_21 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000003096 197.0
HKD2_k127_9857062_22 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.0000000000000000000000000000000000000000000000000000135 203.0
HKD2_k127_9857062_23 Ring hydroxylating beta subunit K18075 - 1.14.12.15 0.000000000000000000000000000000000000000000001226 171.0
HKD2_k127_9857062_24 transcriptional regulator, ArsR family - - - 0.000000000000000000000000000000000000000000001831 168.0
HKD2_k127_9857062_25 Cupin domain K11312 - - 0.00000000000000000000000000000000000000001057 156.0
HKD2_k127_9857062_26 Glutathione-dependent formaldehyde-activating enzyme family protein 3 - - - 0.00000000000000000000000000000000006404 139.0
HKD2_k127_9857062_27 Protein of unknown function (DUF2000) - - - 0.0000000000000000000000000000000002291 138.0
HKD2_k127_9857062_29 Protein of unknown function (DUF2000) - - - 0.000003265 58.0
HKD2_k127_9857062_3 Patatin-like phospholipase K07001 - - 0.0 1030.0
HKD2_k127_9857062_30 Protein of unknown function (DUF2000) - - - 0.0008714 46.0
HKD2_k127_9857062_4 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 9.474e-293 901.0
HKD2_k127_9857062_5 Flavoprotein involved in K transport - - - 7.997e-281 870.0
HKD2_k127_9857062_6 Amidase - - - 1.753e-273 847.0
HKD2_k127_9857062_7 Protein of unknown function (DUF2817) - - - 8.479e-209 652.0
HKD2_k127_9857062_8 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 607.0
HKD2_k127_9857062_9 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 567.0
HKD2_k127_9901688_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0 1050.0
HKD2_k127_9901688_1 Amidohydrolase - - - 3.773e-234 727.0
HKD2_k127_9901688_10 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 477.0
HKD2_k127_9901688_11 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 417.0
HKD2_k127_9901688_12 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 358.0
HKD2_k127_9901688_13 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 351.0
HKD2_k127_9901688_14 COG1335 Amidases related to nicotinamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 314.0
HKD2_k127_9901688_15 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000001556 217.0
HKD2_k127_9901688_16 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000003648 142.0
HKD2_k127_9901688_2 Bacterial extracellular solute-binding protein - - - 9.144e-234 729.0
HKD2_k127_9901688_20 PFAM Flp Fap pilin component K02651 - - 0.00008055 46.0
HKD2_k127_9901688_21 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0003381 48.0
HKD2_k127_9901688_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008412 600.0
HKD2_k127_9901688_4 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 564.0
HKD2_k127_9901688_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 561.0
HKD2_k127_9901688_6 transferase activity, transferring glycosyl groups K16558 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 552.0
HKD2_k127_9901688_7 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 525.0
HKD2_k127_9901688_8 HeAt shock protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 530.0
HKD2_k127_9951751_0 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 551.0
HKD2_k127_9951751_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 514.0
HKD2_k127_9951751_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 409.0
HKD2_k127_9951751_3 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 392.0
HKD2_k127_9951751_4 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000946 335.0
HKD2_k127_9951751_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 329.0
HKD2_k127_9951751_6 Conserved region in glutamate synthase - - - 0.000000000000000000000000000000000000000000004011 173.0
HKD2_k127_9951751_7 PFAM Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.0000000000000000000000000000000003835 136.0