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Overview

ID MAG01832
Name HKD2_bin.99
Sample SMP0047
Taxonomy
Kingdom Archaea
Phylum Thermoplasmatota
Class Thermoplasmata
Order Methanomassiliicoccales
Family UBA472
Genus JACXTP01
Species
Assembly information
Completeness (%) 80.63
Contamination (%) 5.46
GC content (%) 58.0
N50 (bp) 2,341
Genome size (bp) 1,764,773

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2072

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10018606_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 587.0
HKD2_k127_10028340_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 539.0
HKD2_k127_10028340_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002307 285.0
HKD2_k127_10028340_2 ribosomal protein S11 K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000002218 218.0
HKD2_k127_10028340_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000003706 215.0
HKD2_k127_10028340_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000004744 188.0
HKD2_k127_10036691_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000005559 216.0
HKD2_k127_10036691_1 PFAM Nitroreductase - - - 0.0000000000000000000000000004836 117.0
HKD2_k127_10049387_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006079 294.0
HKD2_k127_10049387_1 - - - - 0.00000005198 64.0
HKD2_k127_10049387_2 phosphatase activity. It is involved in the biological process described with protein dephosphorylation K14819 GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006109,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008270,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010562,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010675,GO:0010676,GO:0010906,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032872,GO:0032873,GO:0033131,GO:0033133,GO:0033673,GO:0033674,GO:0035335,GO:0036211,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043412,GO:0043506,GO:0043508,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0045859,GO:0045913,GO:0045936,GO:0045937,GO:0046328,GO:0046329,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051347,GO:0051348,GO:0060255,GO:0062012,GO:0065007,GO:0065009,GO:0070302,GO:0070303,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0080134,GO:0080135,GO:0140096,GO:1901564,GO:1902531,GO:1902532,GO:1903299,GO:1903301 3.1.3.16,3.1.3.48 0.00001003 54.0
HKD2_k127_10062613_0 methylated-DNA-[protein]-cysteine S-methyltransferase activity K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000009376 214.0
HKD2_k127_10062613_1 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000005031 194.0
HKD2_k127_10062613_2 CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - 0.0001373 48.0
HKD2_k127_10081369_0 TIGRFAM oligopeptide dipeptide ABC transporter K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 319.0
HKD2_k127_10081369_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000003877 122.0
HKD2_k127_10086199_0 AMP-binding enzyme C-terminal domain - - - 2.246e-196 623.0
HKD2_k127_10086199_1 Sulfate permease K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 315.0
HKD2_k127_10086199_2 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000006097 226.0
HKD2_k127_10097719_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 481.0
HKD2_k127_10097719_1 Uncharacterised protein family (UPF0147) K09721 - - 0.000000000000000000000005786 105.0
HKD2_k127_10097719_2 Peptidase family M28 K01439 - 3.5.1.18 0.000000000000000000000006197 108.0
HKD2_k127_10097719_3 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000003512 100.0
HKD2_k127_10097719_4 Peptidase_C39 like family - - - 0.000000000000000002628 90.0
HKD2_k127_10097719_5 - - - - 0.00000000000001006 76.0
HKD2_k127_10102021_0 radical SAM K06871 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 518.0
HKD2_k127_10104107_0 Hydantoinase/oxoprolinase N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 574.0
HKD2_k127_10104107_1 Protein of unknown function (DUF2961) K14109 - - 0.000000000003405 71.0
HKD2_k127_10106537_0 K -dependent Na Ca exchanger K07301 - - 0.00000000000000000000000000000214 128.0
HKD2_k127_10106537_1 Titin-like K12567 GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0001701,GO:0001756,GO:0001932,GO:0002020,GO:0002576,GO:0002791,GO:0002793,GO:0003002,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003300,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0004713,GO:0005198,GO:0005200,GO:0005488,GO:0005509,GO:0005515,GO:0005516,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005865,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007076,GO:0007154,GO:0007165,GO:0007275,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007512,GO:0007517,GO:0008015,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009893,GO:0009952,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010737,GO:0010927,GO:0014706,GO:0014866,GO:0014896,GO:0014897,GO:0015629,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0021591,GO:0022402,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030239,GO:0030240,GO:0030241,GO:0030261,GO:0030506,GO:0031032,GO:0031033,GO:0031034,GO:0031323,GO:0031399,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033058,GO:0033275,GO:0034622,GO:0035051,GO:0035265,GO:0035282,GO:0035556,GO:0035994,GO:0035995,GO:0036211,GO:0036379,GO:0040007,GO:0040011,GO:0042221,GO:0042325,GO:0042692,GO:0042802,GO:0042805,GO:0043009,GO:0043056,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043549,GO:0043621,GO:0043933,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045055,GO:0045214,GO:0045859,GO:0046872,GO:0046903,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048644,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048739,GO:0048747,GO:0048769,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051246,GO:0051276,GO:0051338,GO:0051371,GO:0051393,GO:0051592,GO:0051606,GO:0051716,GO:0055001,GO:0055002,GO:0055003,GO:0055006,GO:0055007,GO:0055008,GO:0055013,GO:0060047,GO:0060048,GO:0060255,GO:0060322,GO:0060415,GO:0060419,GO:0060429,GO:0060537,GO:0061053,GO:0061061,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070252,GO:0070925,GO:0071103,GO:0071688,GO:0071704,GO:0071840,GO:0072359,GO:0080090,GO:0090087,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0140014,GO:0140096,GO:1901077,GO:1901564,GO:1901897,GO:1903047,GO:1903530,GO:1903532,GO:1904951 2.7.11.1 0.00008408 53.0
HKD2_k127_1010956_0 Carbon-nitrogen hydrolase K18540 - 3.5.1.100 0.0000000000000000000000000000000000000000005058 162.0
HKD2_k127_1010956_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000001195 132.0
HKD2_k127_1010956_2 amino acid-binding ACT domain protein - - - 0.000000000000002582 82.0
HKD2_k127_10122166_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 284.0
HKD2_k127_10122166_1 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000002121 124.0
HKD2_k127_1012999_0 PFAM Uncharacterised conserved protein UCP006557, signal transduction - - - 0.00000000000000000000000002143 117.0
HKD2_k127_1012999_1 Carboxymuconolactone decarboxylase family - - - 0.00000000000002598 78.0
HKD2_k127_1012999_2 - - - - 0.000002366 53.0
HKD2_k127_10130891_0 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000117 180.0
HKD2_k127_10130891_1 PFAM metal-dependent phosphohydrolase, HD sub domain K06951 - - 0.000000000000000000000000000000000000002032 153.0
HKD2_k127_10135410_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 538.0
HKD2_k127_10138640_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 477.0
HKD2_k127_10138640_1 Aminotransferase class-III K00821,K05830 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 410.0
HKD2_k127_10138640_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 285.0
HKD2_k127_10157964_0 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000004935 259.0
HKD2_k127_10157964_1 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000008334 198.0
HKD2_k127_10157964_2 Right handed beta helix region - - - 0.000000000000000000000000000000002062 151.0
HKD2_k127_10157964_3 COG1520 FOG WD40-like repeat - - - 0.000001758 62.0
HKD2_k127_10187838_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 582.0
HKD2_k127_10187838_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 532.0
HKD2_k127_10187838_2 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000005215 257.0
HKD2_k127_10187838_3 Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity) K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000007672 176.0
HKD2_k127_10187838_4 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.0000001953 60.0
HKD2_k127_10187838_5 involved in rRNA processing K07569 - - 0.0000003468 55.0
HKD2_k127_10187838_6 Double zinc ribbon - - - 0.0002828 52.0
HKD2_k127_1018932_0 NAD(P)-binding Rossmann-like domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009407 405.0
HKD2_k127_1018932_1 Heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002996 280.0
HKD2_k127_1021267_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 364.0
HKD2_k127_1021267_1 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000003939 265.0
HKD2_k127_1021267_2 Bacterio-opsin activator HTH domain-containing protein K06930 - - 0.0000000000000000000000007973 113.0
HKD2_k127_1048187_0 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008169 364.0
HKD2_k127_1048187_1 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000002519 202.0
HKD2_k127_1061884_0 Fibronectin type III domain protein - - - 0.000000000000000000000000002563 125.0
HKD2_k127_1061884_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000006354 93.0
HKD2_k127_1062228_0 Anticodon binding domain K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 7.229e-220 695.0
HKD2_k127_1062228_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005471 254.0
HKD2_k127_1071197_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 303.0
HKD2_k127_1071197_1 Domain of unknown function (DUF4129) - - - 0.000000009228 66.0
HKD2_k127_1075130_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000000000000000001459 153.0
HKD2_k127_1075130_1 F0F1-type ATP synthase, subunit c archaeal vacuolar-type H -ATPase, subunit K K02124 - - 0.00000000000000000004875 91.0
HKD2_k127_1075130_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000003315 56.0
HKD2_k127_1082842_0 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 316.0
HKD2_k127_1082842_1 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000005252 142.0
HKD2_k127_1082842_2 Domain of unknown function (DUF296) - - - 0.0000000000000000000000000000000009928 132.0
HKD2_k127_1082842_3 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000002364 56.0
HKD2_k127_1092610_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 411.0
HKD2_k127_1092610_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000003665 185.0
HKD2_k127_109506_0 GAF domain - - - 0.000000000000000000000000000001417 134.0
HKD2_k127_109506_1 TIGRFAM PAS sensor protein - - - 0.00000001186 66.0
HKD2_k127_1097642_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 326.0
HKD2_k127_1097642_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 290.0
HKD2_k127_1097642_2 PFAM NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 291.0
HKD2_k127_1097642_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001071 210.0
HKD2_k127_1097642_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000000000005844 115.0
HKD2_k127_1098299_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 2.086e-211 664.0
HKD2_k127_1098299_1 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000008951 175.0
HKD2_k127_1098299_2 Protein of unknown function (DUF835) - - - 0.00000002506 61.0
HKD2_k127_110121_0 Sulfatase K01130 - 3.1.6.1 1.966e-309 952.0
HKD2_k127_1107231_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 4.262e-259 820.0
HKD2_k127_1110178_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000153 266.0
HKD2_k127_1110178_1 Protein of unknown function (DUF531) K09725 - - 0.00000000000001106 76.0
HKD2_k127_1110178_2 - - - - 0.00000002369 57.0
HKD2_k127_1130820_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 447.0
HKD2_k127_1130820_1 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000366 77.0
HKD2_k127_1145020_0 Protein of unknown function TPD sequence-motif - - - 0.00000000000000000000000000000000000000000000000000000000000000007918 230.0
HKD2_k127_1145020_1 TIGRFAM CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.0000000001263 66.0
HKD2_k127_115482_0 MMPL family K06994 - - 0.00000000000000000000000000000000000000000000000000000002524 211.0
HKD2_k127_1155508_0 Beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000007774 235.0
HKD2_k127_1169754_0 UvrD REP helicase K03657,K16898 - 3.6.4.12 0.000000000000000001135 94.0
HKD2_k127_1169754_1 PA14 domain - - - 0.000000000000000003507 95.0
HKD2_k127_1170622_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000001706 202.0
HKD2_k127_1170622_1 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000006502 126.0
HKD2_k127_1170622_2 Nucleotidyl transferase K00966,K04042 GO:0003674,GO:0003824,GO:0003977,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0070569 2.3.1.157,2.7.7.13,2.7.7.23 0.00000000000000006739 81.0
HKD2_k127_1171222_0 Uroporphyrinogen decarboxylase K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 391.0
HKD2_k127_1188504_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 435.0
HKD2_k127_1188504_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 402.0
HKD2_k127_1188504_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003162 266.0
HKD2_k127_1192032_0 Helix-turn-helix XRE-family like proteins K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 319.0
HKD2_k127_1192032_1 - - - - 0.0000000000000000002907 95.0
HKD2_k127_1192032_2 AAA family ATPase, CDC48 subfamily K13525 - - 0.00002618 48.0
HKD2_k127_1192032_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0002601 51.0
HKD2_k127_120174_0 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000007591 240.0
HKD2_k127_120174_1 Protein of unknown function DUF58 - - - 0.0008835 45.0
HKD2_k127_1206997_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006994 287.0
HKD2_k127_1212287_0 fumarate reductase K18210 - 1.3.4.1 0.00000000002359 68.0
HKD2_k127_1212287_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000003178 56.0
HKD2_k127_1256980_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 338.0
HKD2_k127_1256980_1 Polysaccharide biosynthesis protein K01784,K02473,K03274 - 5.1.3.2,5.1.3.20,5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 305.0
HKD2_k127_1256980_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000009998 126.0
HKD2_k127_1260994_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 355.0
HKD2_k127_1260994_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000009166 115.0
HKD2_k127_1260994_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000002416 85.0
HKD2_k127_1260994_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.00000000003119 71.0
HKD2_k127_1274498_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 549.0
HKD2_k127_1281791_0 PFAM Beta propeller domain K14475 - - 0.000000000000000000000000000000000000000000000000000000000000006222 240.0
HKD2_k127_1281791_1 Transcriptional regulator - - - 0.0000000000001225 79.0
HKD2_k127_1283508_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 552.0
HKD2_k127_1283508_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000001226 245.0
HKD2_k127_1356048_0 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.0000000000000000000000000000000000000000000000000000007486 199.0
HKD2_k127_1356048_1 B12 binding domain - - - 0.0000000000000000000000000000000000000000000001965 175.0
HKD2_k127_1356048_2 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.000000000000000000002641 96.0
HKD2_k127_1356048_3 Short repeat of unknown function (DUF308) - - - 0.0000000000000000004491 96.0
HKD2_k127_1356048_4 Methyltransferase MtaA K14080 - 2.1.1.246 0.00000000000002625 85.0
HKD2_k127_1364481_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 608.0
HKD2_k127_1373189_0 PFAM Glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000005231 205.0
HKD2_k127_1373189_1 Helix-turn-helix domain - - - 0.00000000000000000000000000002985 124.0
HKD2_k127_1373189_2 - - - - 0.000000000000000000000000005843 112.0
HKD2_k127_1373189_3 Conserved hypothetical protein 95 K07579 - - 0.0000000004652 61.0
HKD2_k127_137782_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 453.0
HKD2_k127_137782_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 317.0
HKD2_k127_137782_2 Dual specificity phosphatase, catalytic domain K14819 GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006109,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008270,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010562,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010675,GO:0010676,GO:0010906,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032872,GO:0032873,GO:0033131,GO:0033133,GO:0033673,GO:0033674,GO:0035335,GO:0036211,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043412,GO:0043506,GO:0043508,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0045859,GO:0045913,GO:0045936,GO:0045937,GO:0046328,GO:0046329,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051347,GO:0051348,GO:0060255,GO:0062012,GO:0065007,GO:0065009,GO:0070302,GO:0070303,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0080134,GO:0080135,GO:0140096,GO:1901564,GO:1902531,GO:1902532,GO:1903299,GO:1903301 3.1.3.16,3.1.3.48 0.0000001051 59.0
HKD2_k127_1383558_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000005857 205.0
HKD2_k127_1383558_1 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000003794 175.0
HKD2_k127_1383558_2 Adenosylcobinamide amidohydrolase - - - 0.00000000000000000000000000000000002448 149.0
HKD2_k127_1383558_3 Aminotransferase class I and II K00817,K04720 - 2.6.1.9,4.1.1.81 0.000000000000000000000003807 107.0
HKD2_k127_1394343_0 Methyltransferase domain K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000001256 169.0
HKD2_k127_1394343_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 0.0000000000000000000000000000000000000009908 152.0
HKD2_k127_1397428_0 aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 331.0
HKD2_k127_1438825_0 Belongs to the complex I 49 kDa subunit family K00333,K14090 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002899 263.0
HKD2_k127_1438825_1 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K14091,K15831 - - 0.0000000000000000000477 95.0
HKD2_k127_1438825_2 Protein of unknown function (DUF1622) - - - 0.0000000000309 68.0
HKD2_k127_1438825_3 Metallophosphoesterase K06953 - - 0.00001716 49.0
HKD2_k127_1462765_0 Psort location CytoplasmicMembrane, score K01531 - 3.6.3.2 1.165e-293 923.0
HKD2_k127_1462765_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000461 257.0
HKD2_k127_1462765_2 - K00960 - 2.7.7.6 0.000000000000001496 78.0
HKD2_k127_1462765_3 mechanosensitive ion channel - - - 0.000000005107 66.0
HKD2_k127_1466609_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000003653 122.0
HKD2_k127_1466609_1 peroxiredoxin activity K03564 - 1.11.1.15 0.000000000000000000002057 99.0
HKD2_k127_1470638_0 Type II/IV secretion system protein K07332 - - 6.446e-210 664.0
HKD2_k127_1471213_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 372.0
HKD2_k127_1471213_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.000000000000000000000000000000000000000000000002004 177.0
HKD2_k127_1471213_2 Thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000003259 165.0
HKD2_k127_1471213_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000308 154.0
HKD2_k127_1471213_4 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000004482 101.0
HKD2_k127_1476409_0 protein conserved in bacteria K09607 - - 0.00000000000000000000000002174 121.0
HKD2_k127_1476409_1 Carboxypeptidase regulatory-like domain - - - 0.000004179 58.0
HKD2_k127_1481619_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002452 277.0
HKD2_k127_1481619_1 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000000000000000000000001046 207.0
HKD2_k127_1481619_2 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000007938 132.0
HKD2_k127_1481619_3 - - - - 0.00000001793 61.0
HKD2_k127_1488454_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 540.0
HKD2_k127_1504789_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 339.0
HKD2_k127_1504789_1 pyruvate phosphate dikinase K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 289.0
HKD2_k127_1504789_2 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000000001204 236.0
HKD2_k127_1504789_3 - - - - 0.0000000000000000000000001106 112.0
HKD2_k127_1504789_4 NUDIX domain K03574 - 3.6.1.55 0.000000000000000314 89.0
HKD2_k127_1504789_5 - - - - 0.000000000000004356 79.0
HKD2_k127_1504789_6 Ribosomal S13/S15 N-terminal domain K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000001605 76.0
HKD2_k127_1504968_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 311.0
HKD2_k127_1504968_1 Protein of unknown function DUF131 - - - 0.00000002117 61.0
HKD2_k127_1506014_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000007592 148.0
HKD2_k127_1506014_1 Bacterial transcriptional activator domain - - - 0.000000000000000000157 102.0
HKD2_k127_1506014_2 Tetratricopeptide repeat - - - 0.000002284 57.0
HKD2_k127_1507484_0 Fibronectin type III domain - - - 0.000000000000000000000000000000006793 145.0
HKD2_k127_1507484_1 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000541 82.0
HKD2_k127_1565871_0 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.00000000000000000000000000000000000001082 153.0
HKD2_k127_1576118_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000009137 264.0
HKD2_k127_1576118_1 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000004862 131.0
HKD2_k127_1576118_2 HEAT repeats - - - 0.0000001659 60.0
HKD2_k127_1613583_0 Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001566 265.0
HKD2_k127_1621094_0 Domain of unknown function DUF87 K06915,K19172 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 537.0
HKD2_k127_1621094_1 TrkA-C domain K03455 - - 0.0000001519 55.0
HKD2_k127_1636549_0 AAA domain - - - 0.000000000000000000000000000000000000002624 168.0
HKD2_k127_1636549_1 Haloacid dehalogenase-like hydrolase - - - 0.0005723 46.0
HKD2_k127_1639789_0 GYD domain - - - 0.0000000000000000000000000000000005214 132.0
HKD2_k127_1639789_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000002671 107.0
HKD2_k127_1639789_2 DNA binding protein K06930 - - 0.000000000000000001604 92.0
HKD2_k127_1643180_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1033.0
HKD2_k127_1643180_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000008408 158.0
HKD2_k127_1643180_2 - - - - 0.0006611 48.0
HKD2_k127_1646879_0 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008323 372.0
HKD2_k127_1648382_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 412.0
HKD2_k127_165056_0 ATPase activity K01990,K19340 - - 0.00000000000000000000004964 102.0
HKD2_k127_165056_1 ABC transporter K01990 - - 0.00000000001183 70.0
HKD2_k127_165056_2 - K01992,K19341 - - 0.0007277 50.0
HKD2_k127_1654104_0 Quinolinate phosphoribosyl transferase, C-terminal domain K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 415.0
HKD2_k127_1654104_1 transcription regulator activity - - - 0.000000000000000000000000000000000000000008313 160.0
HKD2_k127_1654104_2 OsmC-like protein - - - 0.0000000000000000000000000000009402 128.0
HKD2_k127_1654104_3 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000001239 127.0
HKD2_k127_166684_0 E1-E2 ATPase K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 488.0
HKD2_k127_1670717_0 pfkB family carbohydrate kinase K22026 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006213,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008617,GO:0008906,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009129,GO:0009130,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042278,GO:0042455,GO:0043167,GO:0043168,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046033,GO:0046035,GO:0046085,GO:0046087,GO:0046102,GO:0046128,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1905108 2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000003515 222.0
HKD2_k127_1670717_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000002765 97.0
HKD2_k127_1692278_0 Protein kinase domain K08851,K15904 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000006856 196.0
HKD2_k127_1692278_1 HELICc2 K07464,K10844 - 3.1.12.1,3.6.4.12 0.00000000000000000000000000001335 128.0
HKD2_k127_1692278_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000744 61.0
HKD2_k127_1715810_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 392.0
HKD2_k127_1715810_1 Pyruvoyl-dependent arginine decarboxylase K02626 - 4.1.1.19 0.000000000000000004582 85.0
HKD2_k127_1715810_2 - - - - 0.000000000000000009543 93.0
HKD2_k127_1719642_0 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000101 242.0
HKD2_k127_1719642_1 COG2266 GTP adenosylcobinamide-phosphate guanylyltransferase K19712 - 2.7.7.62 0.000000000000003327 83.0
HKD2_k127_1719877_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 430.0
HKD2_k127_1719877_1 TCP-1/cpn60 chaperonin family K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 324.0
HKD2_k127_1719877_2 Helix-turn-helix XRE-family like proteins K03627 - - 0.00000000000000000000000000004254 123.0
HKD2_k127_1719877_3 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000003872 62.0
HKD2_k127_1726678_0 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002604 246.0
HKD2_k127_1726678_1 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 0.000000000000129 73.0
HKD2_k127_1727288_0 pyruvate phosphate dikinase K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 555.0
HKD2_k127_1727288_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000005398 244.0
HKD2_k127_1727288_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000298 152.0
HKD2_k127_1753535_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K03885,K17870 - 1.6.3.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 365.0
HKD2_k127_1753535_1 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 336.0
HKD2_k127_1753535_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000001169 171.0
HKD2_k127_1753535_3 - - - - 0.00000000000000000000003133 102.0
HKD2_k127_1766684_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000134 225.0
HKD2_k127_1767502_0 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005809 264.0
HKD2_k127_1767502_1 - - - - 0.000000000000000000000001367 108.0
HKD2_k127_1777482_0 Arylsulfatase K01130 - 3.1.6.1 0.0 1032.0
HKD2_k127_1777482_1 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000004274 76.0
HKD2_k127_1777553_0 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008823 448.0
HKD2_k127_1786534_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052,K07246,K10978 GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 1.1.1.41,1.1.1.83,1.1.1.85,1.1.1.87,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 377.0
HKD2_k127_1786534_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000001106 241.0
HKD2_k127_1786534_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000006582 203.0
HKD2_k127_1786534_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000006264 192.0
HKD2_k127_1786894_0 PFAM Uncharacterised ArCR, COG2043 - - - 0.000000000000000003787 93.0
HKD2_k127_1786894_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000003834 62.0
HKD2_k127_1790237_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000001008 227.0
HKD2_k127_1790237_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000002515 222.0
HKD2_k127_1804434_0 DHHA1 domain K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 429.0
HKD2_k127_1804434_1 RNase_H superfamily K07502 - - 0.00000000000000000001592 96.0
HKD2_k127_181092_0 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000001486 148.0
HKD2_k127_181092_1 Phosphoesterase - - - 0.0000000000000000005094 93.0
HKD2_k127_1830673_0 Spore germination protein K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004471 282.0
HKD2_k127_1830673_1 ATP-grasp domain - - - 0.0004391 44.0
HKD2_k127_1833480_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 287.0
HKD2_k127_1833480_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000001418 212.0
HKD2_k127_1833480_2 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000002599 216.0
HKD2_k127_1833480_3 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000001724 153.0
HKD2_k127_1833480_4 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000002007 151.0
HKD2_k127_1833480_5 TraB family - - - 0.0000000000000000000000000000000363 142.0
HKD2_k127_1833480_6 archaeal Zn-finger protein - - - 0.00000000000000000000000000001078 125.0
HKD2_k127_1833480_7 PFAM Rhomboid family protein K07059 - - 0.000000000000000000000000205 116.0
HKD2_k127_1841077_0 Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 295.0
HKD2_k127_1841077_1 Conserved hypothetical ATP binding protein K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 292.0
HKD2_k127_1843724_0 binding domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 443.0
HKD2_k127_1843724_1 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000113 224.0
HKD2_k127_1843724_2 NADH ubiquinone oxidoreductase 20 kDa subunit K14128,K17994,K18007 - 1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5 0.00000000000000000009195 90.0
HKD2_k127_1855709_0 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000001326 205.0
HKD2_k127_1855709_1 in signal transduction K08482 - - 0.00000000000000002605 90.0
HKD2_k127_1855709_2 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.000000004011 59.0
HKD2_k127_1867869_0 Hydroxymethylglutaryl-coenzyme A reductase K00021,K00054 - 1.1.1.34,1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 312.0
HKD2_k127_1867869_1 phenylalanine-tRNA ligase activity K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000002939 218.0
HKD2_k127_1868368_0 MMPL family K06994 - - 0.0000000000000000000000000000000000000000726 164.0
HKD2_k127_1877724_0 K homology RNA-binding domain K06961 - - 0.00000000000000000000000000000000000000000000000000000005695 201.0
HKD2_k127_1877724_1 RIO1 family K07178 - 2.7.11.1 0.00000000000000000000000000000000000958 139.0
HKD2_k127_1877724_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.25 0.000000000000000000000002502 106.0
HKD2_k127_1892801_0 PFAM Archaeal ATPase K03524,K06921 - 6.3.4.15 0.000000000000000000000000000536 125.0
HKD2_k127_1905586_0 GPR1 FUN34 yaaH family protein K07034 GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006846,GO:0006855,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015123,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015360,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0043893,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000001092 226.0
HKD2_k127_1905586_1 - - - - 0.0000000000000000000000000000000000000000000000004876 187.0
HKD2_k127_1905586_2 - - - - 0.00000000003477 64.0
HKD2_k127_1925993_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00311,K17830 - 1.3.1.101,1.3.7.11,1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008653 392.0
HKD2_k127_1925993_1 4Fe-4S binding domain - - - 0.000007943 48.0
HKD2_k127_1953259_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000777 409.0
HKD2_k127_1953259_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000005283 162.0
HKD2_k127_1953259_2 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000002982 69.0
HKD2_k127_1966978_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000002681 166.0
HKD2_k127_1966978_1 Proton-conducting membrane transporter K05565,K12137 - - 0.0000000000000000002874 93.0
HKD2_k127_1978543_0 HELICc2 K03722,K10844 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007073 376.0
HKD2_k127_1978543_1 - - - - 0.00000000000000000000000000000000000004387 145.0
HKD2_k127_1989255_0 Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000519 261.0
HKD2_k127_2010114_0 Iron dependent K03709 - - 0.000000000000000000000000000000000000000000000003883 181.0
HKD2_k127_2010114_1 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000001137 81.0
HKD2_k127_2010114_2 Elongator protein 3 MiaB NifB - - - 0.000000000005849 67.0
HKD2_k127_203226_0 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000246 226.0
HKD2_k127_203226_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000002548 218.0
HKD2_k127_203226_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.00000000000000000000003534 103.0
HKD2_k127_203226_3 COG0170 Dolichol kinase - - - 0.0002323 49.0
HKD2_k127_2046384_0 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000000000000000000000000000000002935 223.0
HKD2_k127_2046384_1 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.0000000000000000000000000000000000000000000000009111 182.0
HKD2_k127_2046384_2 PFAM ribosomal protein S8E K02995 GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000000000000000000000000000000000000000002492 161.0
HKD2_k127_2046384_3 Uncharacterized ArCR, COG1888 K09732 - - 0.000000000000000000000000000002326 122.0
HKD2_k127_2046384_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000002615 82.0
HKD2_k127_2052501_0 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002223 246.0
HKD2_k127_2052501_1 - - - - 0.00000000000000000000000000000000000000000000000000002055 208.0
HKD2_k127_2052501_2 protein conserved in archaea - - - 0.000000000000000000002377 97.0
HKD2_k127_2054598_0 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000004829 151.0
HKD2_k127_2054598_1 Protein of unknown function (DUF3795) - - - 0.000000000000000000000000000000002694 132.0
HKD2_k127_205770_0 Glutamate synthase - - - 7.784e-211 667.0
HKD2_k127_205770_1 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 334.0
HKD2_k127_205770_2 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.0000000000000000000000000000000000000000000000000000000000000000002278 232.0
HKD2_k127_205770_3 - - - - 0.000000000000000000000009405 108.0
HKD2_k127_2058705_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000105 52.0
HKD2_k127_2070924_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002902 280.0
HKD2_k127_2070924_1 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000006544 178.0
HKD2_k127_2070924_2 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - - - 0.00000000000447 67.0
HKD2_k127_2070924_3 4Fe-4S dicluster domain - - - 0.000000000631 64.0
HKD2_k127_2108881_0 of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000006709 201.0
HKD2_k127_2108881_1 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000002291 59.0
HKD2_k127_2109723_0 nitrite transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006979 323.0
HKD2_k127_2109723_1 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000006774 55.0
HKD2_k127_2133196_0 PFAM DoxX family protein K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000248 197.0
HKD2_k127_2133196_1 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000002053 175.0
HKD2_k127_2140491_0 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 308.0
HKD2_k127_2140491_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000005427 185.0
HKD2_k127_2140491_2 ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000001318 67.0
HKD2_k127_2161992_0 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K02201 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000002796 138.0
HKD2_k127_2161992_1 Phospholipase/Carboxylesterase - - - 0.00000000000000007292 83.0
HKD2_k127_2161992_2 - - - - 0.0000003706 56.0
HKD2_k127_2163153_0 NADH ubiquinone oxidoreductase 20 kDa subunit K14128,K17994,K18007 - 1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 295.0
HKD2_k127_2163153_1 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000001938 186.0
HKD2_k127_2168832_0 Flp pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000000000002128 239.0
HKD2_k127_2189120_0 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000001219 204.0
HKD2_k127_2189120_1 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000001305 125.0
HKD2_k127_2198738_0 TIGRFAM PAS sensor protein - - - 0.000000001251 69.0
HKD2_k127_2205989_0 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002084 237.0
HKD2_k127_2205989_1 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000001222 91.0
HKD2_k127_2206675_0 aldo-keto reductase (NADP) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 310.0
HKD2_k127_2206675_1 acetyltransferase - - - 0.00000002996 63.0
HKD2_k127_2211929_0 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000004216 202.0
HKD2_k127_2217552_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K09759,K22503 - 6.1.1.12,6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 456.0
HKD2_k127_2217552_1 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.00001303 50.0
HKD2_k127_2218479_0 4Fe-4S single cluster domain K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 378.0
HKD2_k127_2218479_1 Participates in transcription termination K02600 - - 0.00000000000000000000000000000000000000002997 153.0
HKD2_k127_2218479_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000637 124.0
HKD2_k127_2218820_0 FAD binding domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 477.0
HKD2_k127_2218820_1 SMART Excinuclease ABC, C subunit - - - 0.00000000000000000001865 96.0
HKD2_k127_2225576_0 TIGRFAM tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 499.0
HKD2_k127_2225576_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000001706 194.0
HKD2_k127_2236887_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000001041 243.0
HKD2_k127_2236887_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000000000000000000000000000000000000000000000000000000000001938 224.0
HKD2_k127_2236887_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000001129 202.0
HKD2_k127_2249658_0 PFAM glutamate synthase alpha subunit domain protein - - - 0.000000000000000000000000000000000000000000000000000001759 197.0
HKD2_k127_2249658_1 COG1522 Transcriptional regulators K03718 - - 0.000000000000000000004672 98.0
HKD2_k127_2261548_0 S-layer homology domain - - - 0.00001796 57.0
HKD2_k127_2288094_0 aminopeptidase activity K01264,K01301 - 3.4.11.15,3.4.17.21 0.000000000000000003704 97.0
HKD2_k127_2290764_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007657 276.0
HKD2_k127_2290764_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000000000000000000000000000000000181 201.0
HKD2_k127_2294851_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 390.0
HKD2_k127_2294851_1 Lipocalin-like domain K03098 - - 0.000000000000000000000000000000000000000000000000002911 186.0
HKD2_k127_229693_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 351.0
HKD2_k127_229693_1 Pas domain s-box - - - 0.00000001708 60.0
HKD2_k127_2298307_0 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 503.0
HKD2_k127_2299512_0 GPR1 FUN34 yaaH family protein K07034 GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006846,GO:0006855,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015123,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015360,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0043893,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000002365 228.0
HKD2_k127_2299512_1 phosphohistidine phosphatase, SixA K03574,K08296 - 3.6.1.55 0.000000000003837 69.0
HKD2_k127_2299512_2 META domain - - - 0.0000000004952 65.0
HKD2_k127_2302167_0 Rhodanese-like domain K01069 - 3.1.2.6 0.000000000000000000000000000005902 124.0
HKD2_k127_2302167_1 Transcriptional regulator K07722 - - 0.00007437 47.0
HKD2_k127_2307674_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000008475 139.0
HKD2_k127_2307674_1 reductase K00059 - 1.1.1.100 0.000000000000000000003512 106.0
HKD2_k127_2307674_2 NAD(P)H dehydrogenase (quinone) activity - - - 0.000000004842 61.0
HKD2_k127_2319134_0 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000956 342.0
HKD2_k127_2319134_1 - - - - 0.000002321 50.0
HKD2_k127_2320055_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000009047 138.0
HKD2_k127_2328533_0 Acetyl-CoA acetyltransferase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 544.0
HKD2_k127_2328533_1 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 312.0
HKD2_k127_2328533_2 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 6.3.4.22 0.0000000000000000000000000000000000001084 147.0
HKD2_k127_2341616_0 Voltage-dependent anion channel K11041 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006426 280.0
HKD2_k127_2362101_0 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000001224 166.0
HKD2_k127_2362101_1 - K00960 - 2.7.7.6 0.000000000000000009085 84.0
HKD2_k127_2362101_2 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000002933 82.0
HKD2_k127_2362101_3 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000001979 81.0
HKD2_k127_2376873_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 541.0
HKD2_k127_2376873_1 Protein of unknown function (DUF1641) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004653 267.0
HKD2_k127_2376873_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000003165 175.0
HKD2_k127_2376873_3 response regulator, receiver - - - 0.000000000000000001476 87.0
HKD2_k127_239279_0 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 522.0
HKD2_k127_239279_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 302.0
HKD2_k127_2414760_0 Belongs to the UPF0273 family - - - 0.00000008056 55.0
HKD2_k127_2423729_0 carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 366.0
HKD2_k127_2423729_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000004557 161.0
HKD2_k127_2435139_0 DnaB-like helicase C terminal domain - - - 0.00000000000000000000000007295 114.0
HKD2_k127_2435139_1 SMART AAA ATPase K08482 - - 0.00001137 57.0
HKD2_k127_2439371_0 BFD domain protein 2Fe-2S -binding domain protein K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 340.0
HKD2_k127_2439371_1 Domain of unknown function (DUF362) K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001559 279.0
HKD2_k127_2439371_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000001041 193.0
HKD2_k127_2439371_3 SCP-2 sterol transfer family - - - 0.000000000003659 72.0
HKD2_k127_245420_0 methanogen marker protein 4 - - - 0.0000000000000000000000000000000000000000000000000000003194 202.0
HKD2_k127_245420_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000001542 164.0
HKD2_k127_245420_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000006552 96.0
HKD2_k127_2461706_0 COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - 0.000000000000000000000000000000000000000000000000000000003157 211.0
HKD2_k127_2489396_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 2.683e-312 968.0
HKD2_k127_2489396_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002401 270.0
HKD2_k127_2489396_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000001137 243.0
HKD2_k127_2489396_3 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11 0.000000000000003438 78.0
HKD2_k127_2503927_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000001913 137.0
HKD2_k127_2503927_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000001702 126.0
HKD2_k127_2510742_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 1.86e-205 651.0
HKD2_k127_2510742_1 Methyl-viologen-reducing hydrogenase, delta subunit K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000005367 183.0
HKD2_k127_2520907_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004916 278.0
HKD2_k127_2520907_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000008452 181.0
HKD2_k127_2520907_2 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000001123 155.0
HKD2_k127_2520907_3 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.0000000000000000009883 88.0
HKD2_k127_2529664_1 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000023 65.0
HKD2_k127_2531976_0 - - - - 0.0000000000000000000000000000000000000000000002975 181.0
HKD2_k127_2531976_1 PFAM Mo-dependent nitrogenase - - - 0.00000000000000000000000000000001038 132.0
HKD2_k127_2531976_2 PFAM GCN5-related N-acetyltransferase K03790 - 2.3.1.128 0.000000000000000000000000007012 113.0
HKD2_k127_2546451_0 DNA polymerase K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 527.0
HKD2_k127_2546451_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 344.0
HKD2_k127_2546451_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006742 251.0
HKD2_k127_2546451_3 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601,K08965 - 4.1.1.39,5.3.2.5 0.00000000000000000000006354 105.0
HKD2_k127_2552008_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 564.0
HKD2_k127_255399_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 527.0
HKD2_k127_255399_1 Thioredoxin - - - 0.0000000000000000008374 91.0
HKD2_k127_255399_2 Thioredoxin K03671 - - 0.00000006098 57.0
HKD2_k127_2570715_0 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000009603 244.0
HKD2_k127_2570715_1 Uroporphyrinogen decarboxylase (URO-D) K01599,K14080 - 2.1.1.246,4.1.1.37 0.0005558 48.0
HKD2_k127_2574256_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 445.0
HKD2_k127_2574256_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000007711 228.0
HKD2_k127_2574256_2 PFAM cobalamin (vitamin B12) biosynthesis CbiM K02007 - - 0.000000000000000000000000000000000000000000000006994 180.0
HKD2_k127_2574256_3 cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000001727 119.0
HKD2_k127_2574256_4 PDGLE domain K02009 - - 0.00006204 50.0
HKD2_k127_2581481_0 RibD C-terminal domain K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000003361 211.0
HKD2_k127_2581481_1 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000001382 126.0
HKD2_k127_2581481_2 - - - - 0.000007112 48.0
HKD2_k127_2586400_0 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000000000000000000000000001749 243.0
HKD2_k127_2586400_1 Anticodon binding domain K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.0000000000000000000000000000000001633 134.0
HKD2_k127_2586511_0 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 450.0
HKD2_k127_2586511_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000003908 199.0
HKD2_k127_2592194_0 Leucine rich repeats (6 copies) - - - 0.000000000000000000000000000000000000000000000000000000000003819 222.0
HKD2_k127_259358_0 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000001375 138.0
HKD2_k127_259358_1 DsrE/DsrF-like family K07235 - - 0.0000000000000000000000000000000001504 135.0
HKD2_k127_259358_2 protein involved in the oxidation of intracellular sulfur K07236 - - 0.00000000000000000177 89.0
HKD2_k127_259358_3 DsrH like protein K07237 - - 0.000000000000614 72.0
HKD2_k127_2615099_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 0.0000000000000000000000000000000000000000000000000000003632 200.0
HKD2_k127_2616744_0 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000004603 120.0
HKD2_k127_2616744_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000146 96.0
HKD2_k127_2623637_0 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 341.0
HKD2_k127_2624236_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000001532 222.0
HKD2_k127_2649001_0 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000001538 181.0
HKD2_k127_2649001_1 DEAD/H associated K03724 - - 0.00000000000000000000000000000000000000000003422 175.0
HKD2_k127_2652576_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001833 244.0
HKD2_k127_2652576_1 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000002684 144.0
HKD2_k127_2655083_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 407.0
HKD2_k127_2655083_1 oligoendopeptidase F K08602 - - 0.0000000000000000000000000000000000002086 153.0
HKD2_k127_2687685_0 DEAD/H associated K03724 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.000000000000000000000000000138 116.0
HKD2_k127_2687685_1 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000002921 94.0
HKD2_k127_2687685_2 cell wall anchor domain - - - 0.000000000000001397 88.0
HKD2_k127_2693102_0 snoRNA binding domain, fibrillarin K14564 GO:0000154,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030515,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 389.0
HKD2_k127_2693102_1 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000004295 166.0
HKD2_k127_2693102_2 Class II aldolase K01628,K03077 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019321,GO:0019323,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575 4.1.2.17,5.1.3.4 0.00000000000000000000000000000000000000000005355 168.0
HKD2_k127_2789446_0 PFAM Nickel-dependent hydrogenase, large subunit K00436,K14126,K17993 - 1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5 1.741e-197 627.0
HKD2_k127_2789446_1 Calcineurin-like phosphoesterase superfamily domain K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002649 248.0
HKD2_k127_2789446_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000001871 204.0
HKD2_k127_2789446_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000002734 65.0
HKD2_k127_2791006_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 365.0
HKD2_k127_2791006_1 lipoprotein NlpE involved in copper resistance - - - 0.00000000000000000000000000000002795 134.0
HKD2_k127_2794779_0 - - - - 0.00000005855 57.0
HKD2_k127_2794779_1 Conserved hypothetical ATP binding protein K06883 - - 0.0000005753 52.0
HKD2_k127_2799489_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002236 278.0
HKD2_k127_2799489_1 PFAM Peptidase - - - 0.00000000000000000000000000000000000007524 152.0
HKD2_k127_2799489_2 FAD binding domain K00104 - 1.1.3.15 0.00000000000000000000000000000009049 126.0
HKD2_k127_2814334_0 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000001078 224.0
HKD2_k127_2814334_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K03885,K17870 - 1.6.3.3,1.6.99.3 0.0000000000000000000000000000000000000000000000006849 178.0
HKD2_k127_2823382_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000001836 189.0
HKD2_k127_2834923_0 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000008127 164.0
HKD2_k127_2851106_0 phenylalanine-tRNA ligase activity K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 469.0
HKD2_k127_2851106_1 Phospholipase/Carboxylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005593 246.0
HKD2_k127_2872537_0 heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000975 193.0
HKD2_k127_2872537_1 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000002508 64.0
HKD2_k127_2882161_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 528.0
HKD2_k127_2882161_1 Zinc-binding dehydrogenase - - - 0.000000000000000536 83.0
HKD2_k127_2895709_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 2.349e-312 970.0
HKD2_k127_2895709_1 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 361.0
HKD2_k127_2895709_2 - - - - 0.0000000000000000000000000000000198 138.0
HKD2_k127_2895709_3 Peptidase family M50 - - - 0.00000000000000000000001202 102.0
HKD2_k127_2918251_0 toxin activity - - - 0.00000000000000000000000001502 122.0
HKD2_k127_2918251_1 - - - - 0.0000000000000000000000001282 111.0
HKD2_k127_2918251_2 Type II/IV secretion system protein K07332 - - 0.000000000000000000008013 98.0
HKD2_k127_2941921_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000002265 231.0
HKD2_k127_2941921_1 Belongs to the glycosyl hydrolase family 6 K19668 - 3.2.1.91 0.0000000000000000000000000001913 127.0
HKD2_k127_2944007_1 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000002083 122.0
HKD2_k127_2944007_2 Mitochondrial biogenesis AIM24 - - - 0.000000000000000000007624 93.0
HKD2_k127_2944007_3 regulatory protein, arsR - - - 0.000000009096 65.0
HKD2_k127_2949715_0 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 313.0
HKD2_k127_2949715_1 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000001948 51.0
HKD2_k127_2973559_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 487.0
HKD2_k127_2973559_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 471.0
HKD2_k127_2973559_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000009445 260.0
HKD2_k127_2973559_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000003193 211.0
HKD2_k127_2980283_0 Archaeal transcriptional regulator TrmB - - - 0.00000007736 54.0
HKD2_k127_2983514_0 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000001327 186.0
HKD2_k127_2983514_1 Protein of unknown function (DUF2961) - - - 0.000000000000000000000000000000000000000004513 161.0
HKD2_k127_2987427_0 COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase K00817,K04720 - 2.6.1.9,4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000001497 247.0
HKD2_k127_2987427_1 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000006445 104.0
HKD2_k127_300202_0 - - - - 0.000000000000001168 80.0
HKD2_k127_3002460_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 8.052e-203 643.0
HKD2_k127_3035403_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000002024 247.0
HKD2_k127_3035403_1 Universal stress protein family - - - 0.00000000000000000000000000000000000000005542 158.0
HKD2_k127_3035403_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000001305 142.0
HKD2_k127_3037424_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 481.0
HKD2_k127_3037424_1 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005049 285.0
HKD2_k127_3037424_2 - - - - 0.0000000000000004759 87.0
HKD2_k127_3037603_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 313.0
HKD2_k127_3080181_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000001515 213.0
HKD2_k127_3116491_0 helix_turn_helix ASNC type - - - 0.0000001106 56.0
HKD2_k127_3124854_0 PFAM Glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000007278 165.0
HKD2_k127_3124854_1 Belongs to the glutamate synthase family - - - 0.00000000000000000000000000000000000000001177 165.0
HKD2_k127_3130551_0 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 385.0
HKD2_k127_3130551_1 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 376.0
HKD2_k127_3130551_2 COG0095 Lipoate-protein ligase A K03800 GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681 6.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000008763 235.0
HKD2_k127_3132101_0 COGs COG0145 N-methylhydantoinase A acetone carboxylase beta subunit - - - 0.000000000000000000000000000001944 125.0
HKD2_k127_3132101_1 Protein of unknown function (DUF2961) - - - 0.00000000005237 72.0
HKD2_k127_3140339_0 RIO-like kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000008463 259.0
HKD2_k127_3140339_1 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000001635 134.0
HKD2_k127_3140339_2 K homology RNA-binding domain K06961 - - 0.0000000000000000006315 98.0
HKD2_k127_3155650_0 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000001022 203.0
HKD2_k127_3155650_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000007017 122.0
HKD2_k127_315898_0 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 342.0
HKD2_k127_315898_1 Protein of unknown function (DUF1254) - - - 0.0000000000000000000000000000000000000000000000000177 191.0
HKD2_k127_3168309_0 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 608.0
HKD2_k127_3168309_1 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.00000000000000000000000000000004195 129.0
HKD2_k127_3185618_0 transcriptional regulator, SARP family - - - 0.00003376 53.0
HKD2_k127_3206203_0 PFAM Hydantoinase oxoprolinase - - - 0.000000000000000000000000000000000000000000000000001664 198.0
HKD2_k127_3206203_1 transcriptional regulators - - - 0.000004244 53.0
HKD2_k127_3206491_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 460.0
HKD2_k127_3206491_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 357.0
HKD2_k127_3206491_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 314.0
HKD2_k127_3206491_3 Uncharacterized protein conserved in archaea (DUF2099) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 301.0
HKD2_k127_3206491_4 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003493 282.0
HKD2_k127_3206491_5 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.000000000000000000000000000000000000000000002745 168.0
HKD2_k127_3206491_6 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000004891 120.0
HKD2_k127_3206491_7 Fcf1 K07158 - - 0.00000000000000000000000001075 113.0
HKD2_k127_3220195_0 AAA domain K07331 - - 0.000000000000000000000000000000000000000000000000000004089 198.0
HKD2_k127_3220195_1 Type II/IV secretion system protein K07332 - - 0.00000000000000000000000000000000000000000001525 171.0
HKD2_k127_3220195_2 Archaebacterial flagellin K07330 - - 0.0000000000000003027 84.0
HKD2_k127_3234904_0 Dehydrogenase E1 component K00161,K00166,K21416 GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 378.0
HKD2_k127_3234904_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 308.0
HKD2_k127_3239108_0 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000005676 266.0
HKD2_k127_3253179_0 RibD C-terminal domain K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000001308 213.0
HKD2_k127_3253179_1 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000006534 132.0
HKD2_k127_3253179_2 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000001286 128.0
HKD2_k127_3253179_3 - - - - 0.0000000000000000000000002329 120.0
HKD2_k127_3283870_0 Resolvase, N terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000101 208.0
HKD2_k127_3283870_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000001023 64.0
HKD2_k127_3307864_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 423.0
HKD2_k127_3307864_1 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000001136 149.0
HKD2_k127_3332758_0 major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003134 282.0
HKD2_k127_3332758_1 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000865 63.0
HKD2_k127_334803_0 Archaeal Type IV pilin, N-terminal - - - 0.0000006071 62.0
HKD2_k127_3361423_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002737 270.0
HKD2_k127_3361423_1 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000003791 211.0
HKD2_k127_3361423_2 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000002989 200.0
HKD2_k127_3361423_3 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000003215 63.0
HKD2_k127_3367571_0 UbiA prenyltransferase family K02548 - 2.5.1.74 0.0000000000000000000000000007095 125.0
HKD2_k127_3367571_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000003556 107.0
HKD2_k127_3367571_2 Protein of unknown function (DUF2769) - - - 0.00000000000000000001908 94.0
HKD2_k127_3367571_3 Protein of unknown function (DUF2769) - - - 0.0000000000000000000676 93.0
HKD2_k127_3367571_4 Transcriptional regulator K07332 - - 0.0000000000000000006716 94.0
HKD2_k127_3399735_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 1.176e-220 698.0
HKD2_k127_3399735_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 394.0
HKD2_k127_3399735_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 283.0
HKD2_k127_3399735_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006541 273.0
HKD2_k127_3399735_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000005882 114.0
HKD2_k127_3399735_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000000002114 106.0
HKD2_k127_3399735_6 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000001217 84.0
HKD2_k127_3433540_0 KH domain K07041 - - 1.169e-272 851.0
HKD2_k127_3433540_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000004065 143.0
HKD2_k127_3433540_2 - - - - 0.0000000000000000000000000003712 117.0
HKD2_k127_3433540_3 - - - - 0.0000004895 55.0
HKD2_k127_3435409_0 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 492.0
HKD2_k127_3435409_1 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000163 280.0
HKD2_k127_3439806_0 COG0277 FAD FMN-containing dehydrogenases K00102,K00104,K06911 - 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007709 533.0
HKD2_k127_3439806_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000001161 240.0
HKD2_k127_3439806_2 Peptidase family M50 - - - 0.000000000000000000000000000001331 125.0
HKD2_k127_3439806_3 PhoU domain - - - 0.0008002 42.0
HKD2_k127_3442072_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 458.0
HKD2_k127_3442072_1 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000001053 183.0
HKD2_k127_3442072_2 - - - - 0.00000000000000000000000126 104.0
HKD2_k127_3442072_3 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000004836 73.0
HKD2_k127_3444611_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 402.0
HKD2_k127_3444611_1 Universal stress protein family - - - 0.00000007102 63.0
HKD2_k127_3456191_0 acetyl-CoA catabolic process K00197,K03616 - 2.1.1.245 0.000000000000000000000000000000002661 136.0
HKD2_k127_3456191_1 Domain of unknown function (DUF4445) - - - 0.0000000000000000007824 88.0
HKD2_k127_3456191_2 Methanol-cobalamin methyltransferase B subunit K04480 - 2.1.1.90 0.00000000000108 71.0
HKD2_k127_34575_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004236 282.0
HKD2_k127_34575_1 - - - - 0.0000000000000000000005461 102.0
HKD2_k127_3465845_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 471.0
HKD2_k127_3465845_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 0.000000001843 59.0
HKD2_k127_3471359_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005064 260.0
HKD2_k127_3471359_1 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
HKD2_k127_3473090_0 Glycosyl Transferase - - - 0.000000000000000000000000000000000000000000000000000001547 203.0
HKD2_k127_3484246_0 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003899 250.0
HKD2_k127_3484246_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000002383 102.0
HKD2_k127_3484246_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000001313 57.0
HKD2_k127_349747_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 373.0
HKD2_k127_349747_1 - - - - 0.00000000000000000000004012 100.0
HKD2_k127_3523585_0 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000005511 110.0
HKD2_k127_3526585_0 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 585.0
HKD2_k127_3526585_1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000001963 225.0
HKD2_k127_3526585_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000002342 174.0
HKD2_k127_3540669_0 Protein of unknown function (DUF2769) - - - 0.000000000007102 69.0
HKD2_k127_3540669_1 Serine aminopeptidase, S33 - - - 0.00000001257 65.0
HKD2_k127_3547773_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 376.0
HKD2_k127_3547773_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000001662 209.0
HKD2_k127_3548796_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000002035 185.0
HKD2_k127_3548796_1 Transcription elongation factor Spt5 K02601 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000001995 188.0
HKD2_k127_3548796_2 TIGRFAM protein translocase SEC61 complex gamma subunit K07342 - - 0.000000000000008846 76.0
HKD2_k127_3550592_0 Polysaccharide biosynthesis protein - - - 0.00000000009764 71.0
HKD2_k127_3550592_1 finger protein K16276 - - 0.0003874 48.0
HKD2_k127_3560728_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000003128 169.0
HKD2_k127_3560728_1 Protein of unknown function (DUF835) - - - 0.0000003057 63.0
HKD2_k127_3579816_0 ATPase involved in replication control, Cdc46 Mcm family K10726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003007 280.0
HKD2_k127_3579816_1 NMD3 family K07562 - - 0.0000000000000000000000000000000000000000000000000000000005796 214.0
HKD2_k127_3579816_2 Protein of unknown function (DUF424) K09148 - - 0.000000000000000002264 94.0
HKD2_k127_3580575_0 dipeptidyl-peptidase activity K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 490.0
HKD2_k127_3585577_0 CO dehydrogenase/acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 292.0
HKD2_k127_359985_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 353.0
HKD2_k127_359985_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.000000000000000000000001032 107.0
HKD2_k127_3623965_0 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000003175 177.0
HKD2_k127_3623965_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000008822 97.0
HKD2_k127_3633170_0 PFAM ATP dependent DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000005416 178.0
HKD2_k127_3633170_1 cheY-homologous receiver domain - - - 0.0000000000000000003599 89.0
HKD2_k127_3634466_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 302.0
HKD2_k127_3634466_1 Restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000361 197.0
HKD2_k127_3664196_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 531.0
HKD2_k127_3664196_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 449.0
HKD2_k127_3664196_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002145 282.0
HKD2_k127_3664196_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000001532 98.0
HKD2_k127_3664196_4 Tetratricopeptide repeat - - - 0.00000000000000001362 88.0
HKD2_k127_3664196_5 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 - - 0.00000000003717 72.0
HKD2_k127_3664283_0 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 315.0
HKD2_k127_3664283_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000006833 62.0
HKD2_k127_3675937_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341,K22167 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 432.0
HKD2_k127_3675937_1 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000003062 198.0
HKD2_k127_3675937_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000327 108.0
HKD2_k127_3675937_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.0000000000002312 73.0
HKD2_k127_3722126_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004658 461.0
HKD2_k127_3722126_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 327.0
HKD2_k127_3730481_0 Arsenite-activated ATPase ArsA K01551 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 374.0
HKD2_k127_3730481_1 Cysteine-rich domain K00241,K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 365.0
HKD2_k127_3730481_10 Domain of unknown function (DUF749) - - - 0.0000001059 57.0
HKD2_k127_3730481_2 structural constituent of ribosome K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000001018 241.0
HKD2_k127_3730481_3 AMMECR1 K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000002408 229.0
HKD2_k127_3730481_4 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000003281 187.0
HKD2_k127_3730481_5 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000005997 179.0
HKD2_k127_3730481_6 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000008953 172.0
HKD2_k127_3730481_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000003443 130.0
HKD2_k127_3730481_8 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000915 128.0
HKD2_k127_3730481_9 spore germination K03605 - - 0.0000000000000001451 88.0
HKD2_k127_3793409_0 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000501 243.0
HKD2_k127_380006_0 COG0531 Amino acid transporters - - - 0.000000000000000000000000000000000000000000000000000001467 208.0
HKD2_k127_380006_1 phosphoesterase RecJ domain protein K07463 - - 0.00000000005874 74.0
HKD2_k127_380006_2 Protein of unknown function (DUF429) - - - 0.00000007594 61.0
HKD2_k127_3809690_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001499 241.0
HKD2_k127_3809690_1 CAAX protease self-immunity K07052 - - 0.000000000000000000000001825 107.0
HKD2_k127_3815833_0 Belongs to the carbamoyltransferase HypF family K04656 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 317.0
HKD2_k127_3815833_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 301.0
HKD2_k127_3815833_2 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000003203 185.0
HKD2_k127_3815833_3 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000005377 172.0
HKD2_k127_3815833_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000879 151.0
HKD2_k127_3815833_5 - - - - 0.0001857 44.0
HKD2_k127_3817017_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000176 280.0
HKD2_k127_3817017_1 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 261.0
HKD2_k127_3817017_2 Psort location Cytoplasmic, score 8.87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001596 241.0
HKD2_k127_3817017_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000009645 237.0
HKD2_k127_3817017_4 2Fe-2S iron-sulfur cluster binding domain K18210 - 1.3.4.1 0.000000000000000000000000000000000000000000000000000000000000000000355 243.0
HKD2_k127_3817017_5 PFAM methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000001651 82.0
HKD2_k127_3817017_6 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000001886 55.0
HKD2_k127_3827870_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 383.0
HKD2_k127_3827870_1 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000006344 109.0
HKD2_k127_3827870_2 helix_turn_helix ASNC type K03718 - - 0.0000000000003516 76.0
HKD2_k127_3844641_0 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000001009 200.0
HKD2_k127_3844641_1 Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) - - - 0.000000001077 66.0
HKD2_k127_3844641_2 MviN-like protein - - - 0.00003139 54.0
HKD2_k127_385458_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000114 191.0
HKD2_k127_385458_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000005879 177.0
HKD2_k127_385458_2 COG0110 Acetyltransferase (isoleucine patch superfamily) - - - 0.0000000000000000000000000000000000000000000004654 171.0
HKD2_k127_3856127_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 GO:0000166,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016208,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042301,GO:0042737,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576 2.4.2.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 438.0
HKD2_k127_3856127_1 - - - - 0.00000000000001554 79.0
HKD2_k127_3857827_0 Endopeptidase La K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 413.0
HKD2_k127_3857827_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 298.0
HKD2_k127_3857827_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000341 109.0
HKD2_k127_3860673_0 - - - - 0.0000000000000001474 84.0
HKD2_k127_3873396_0 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 438.0
HKD2_k127_3873396_1 Uroporphyrinogen decarboxylase (URO-D) K01599,K14080 - 2.1.1.246,4.1.1.37 0.00008374 51.0
HKD2_k127_3874785_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 316.0
HKD2_k127_3874785_1 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006629 280.0
HKD2_k127_3878099_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000003116 138.0
HKD2_k127_3878099_1 4Fe-4S ferredoxin iron-sulfur binding - - - 0.0000000000000001265 91.0
HKD2_k127_3882444_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 337.0
HKD2_k127_3882444_1 PFAM Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008284 254.0
HKD2_k127_3882444_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000005096 119.0
HKD2_k127_3884227_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 295.0
HKD2_k127_3884227_1 Sulfate permease family K03321 - - 0.00000002066 61.0
HKD2_k127_3886314_0 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006281 274.0
HKD2_k127_3886314_1 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000000000574 165.0
HKD2_k127_3886314_2 Mechanosensitive ion channel K03442,K05802,K16052 - - 0.0000005834 52.0
HKD2_k127_3914223_0 CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 497.0
HKD2_k127_3914223_1 CO dehydrogenase acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000001451 182.0
HKD2_k127_3952750_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000001745 248.0
HKD2_k127_3952750_1 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000000000004609 208.0
HKD2_k127_3952750_2 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000000000000000004017 162.0
HKD2_k127_3952805_0 4Fe-4S single cluster domain K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 367.0
HKD2_k127_3952805_1 Archaeal transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000000000000000000000000003806 228.0
HKD2_k127_3953894_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000001412 196.0
HKD2_k127_3953894_1 Bacterial transcription activator, effector binding domain K13652 - - 0.000000000000000000000005015 107.0
HKD2_k127_3953894_2 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.000000000000009413 79.0
HKD2_k127_3956633_0 Required for chromosome condensation and partitioning K03529 - - 0.0000000001114 63.0
HKD2_k127_3956633_1 polysaccharide biosynthetic process - - - 0.000000002957 67.0
HKD2_k127_3985965_0 Toprim domain K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 434.0
HKD2_k127_3985965_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000009884 112.0
HKD2_k127_3985965_2 PFAM Cysteine-rich small domain K07162 - - 0.000000000000000000005694 101.0
HKD2_k127_3989558_0 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.00001655 49.0
HKD2_k127_3989558_1 Protein of unknown function (DUF2797) - - - 0.0002238 52.0
HKD2_k127_3992367_0 Uroporphyrinogen decarboxylase K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 395.0
HKD2_k127_3992367_1 PFAM Methionine synthase, B12-binding module, cap domain protein - - - 0.000000000000000000000000000000000000000000000000000000002958 207.0
HKD2_k127_3992367_2 - - - - 0.00000000000000000001288 94.0
HKD2_k127_3995574_0 CO dehydrogenase acetyl-CoA synthase K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000001029 180.0
HKD2_k127_3995574_1 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000001578 163.0
HKD2_k127_4018181_0 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000001623 117.0
HKD2_k127_4018181_1 Protein of unknown function (DUF1638) - - - 0.00000000004187 68.0
HKD2_k127_4018592_1 - - - - 0.000001155 57.0
HKD2_k127_4032122_0 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 313.0
HKD2_k127_4047396_0 Met-10+ like-protein - - - 0.0000000000003154 74.0
HKD2_k127_4047396_1 COG0668 Small-conductance mechanosensitive channel K03442 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.00000006161 65.0
HKD2_k127_4047396_2 Lamin Tail Domain - - - 0.00000224 58.0
HKD2_k127_4049100_0 Histidine kinase - - - 0.00002636 55.0
HKD2_k127_406104_0 ATPase associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 396.0
HKD2_k127_4066353_0 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 326.0
HKD2_k127_4066353_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000001321 219.0
HKD2_k127_4066353_2 Asparagine synthase K01953 - 6.3.5.4 0.000000000005857 70.0
HKD2_k127_4066353_3 - - - - 0.0004317 43.0
HKD2_k127_4072458_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052,K10978 GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 1.1.1.41,1.1.1.85,1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 456.0
HKD2_k127_4072458_1 aminopeptidase K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 440.0
HKD2_k127_4072458_2 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008431 333.0
HKD2_k127_4072458_3 - - - - 0.0000000006226 62.0
HKD2_k127_408281_0 Methyl-viologen-reducing hydrogenase, delta subunit K22480 - 1.8.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 561.0
HKD2_k127_408281_1 Cysteine-rich domain K03389,K22481 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001265 276.0
HKD2_k127_4083076_0 shikimate kinase activity K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000002061 222.0
HKD2_k127_4083076_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000006184 119.0
HKD2_k127_4083076_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000001113 78.0
HKD2_k127_409251_0 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 368.0
HKD2_k127_409251_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 362.0
HKD2_k127_409251_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003569 285.0
HKD2_k127_409251_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000005852 211.0
HKD2_k127_409251_4 - - - - 0.0000000006096 66.0
HKD2_k127_4094668_0 PFAM Radical SAM K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 328.0
HKD2_k127_4098352_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K09759 - 6.1.1.23 0.0000000000000000000000000000001037 124.0
HKD2_k127_4108219_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 6.877e-291 905.0
HKD2_k127_4108219_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000001032 229.0
HKD2_k127_4108219_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00004337 55.0
HKD2_k127_4120206_0 plastoquinone (Complex I) K12137 - - 2.32e-201 649.0
HKD2_k127_4120206_1 PFAM Major Facilitator Superfamily - - - 0.000000000001063 71.0
HKD2_k127_4123185_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044,K13798 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1327.0
HKD2_k127_4123185_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000001271 99.0
HKD2_k127_4123185_2 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000000002394 91.0
HKD2_k127_4135648_0 Alkyl hydroperoxide reductase K03387 - - 0.00000000000000000000000000000000000000000000000000000000000000004629 243.0
HKD2_k127_4135648_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 0.00000000000000000000000000000522 121.0
HKD2_k127_4142435_0 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003551 279.0
HKD2_k127_4142435_1 EamA-like transporter family - - - 0.000000000000000000001319 106.0
HKD2_k127_4142435_2 Protein of unknown function DUF89 K09116 - - 0.00000000000000000001098 93.0
HKD2_k127_4142435_3 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000001097 85.0
HKD2_k127_4152486_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 559.0
HKD2_k127_4152486_1 PFAM NADH ubiquinone oxidoreductase, 20 kDa subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000001243 190.0
HKD2_k127_4155641_0 helicase activity - - - 4.271e-241 754.0
HKD2_k127_4181530_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001148 272.0
HKD2_k127_4181530_1 PAS domain K02488 - 2.7.7.65 0.000000000000000000000000000004077 132.0
HKD2_k127_4181530_2 cheY-homologous receiver domain K07668 - - 0.0000000000000001673 91.0
HKD2_k127_4188541_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000004077 103.0
HKD2_k127_4188541_1 Right handed beta helix region - - - 0.000000000002252 81.0
HKD2_k127_4188541_2 Amb_all K01728 - 4.2.2.2 0.0000005744 63.0
HKD2_k127_4199999_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 571.0
HKD2_k127_4199999_1 - - - - 0.000001553 52.0
HKD2_k127_4200405_0 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 394.0
HKD2_k127_4200405_1 Hydantoinase/oxoprolinase N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000002725 211.0
HKD2_k127_422030_0 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 401.0
HKD2_k127_422030_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000001642 224.0
HKD2_k127_4221798_0 Domain of unknown function DUF108 K01823,K06989 - 1.4.1.21,5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001468 275.0
HKD2_k127_4221798_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000001303 151.0
HKD2_k127_4221798_2 Metallopeptidase family M24 K01271 - 3.4.13.9 0.000002453 53.0
HKD2_k127_4238291_0 plastoquinone (Complex I) K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 551.0
HKD2_k127_4238291_1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 451.0
HKD2_k127_4238291_2 Hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000158 247.0
HKD2_k127_4238291_3 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000004171 181.0
HKD2_k127_4238291_4 PFAM NADH ubiquinone oxidoreductase, 20 - - - 0.00000000000004463 76.0
HKD2_k127_4241732_0 PFAM Endonuclease Exonuclease phosphatase K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000115 276.0
HKD2_k127_4242604_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.21 0.0000000000000000000000000000000000000000000005896 170.0
HKD2_k127_4242604_1 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000001197 136.0
HKD2_k127_4242604_2 PFAM ribonuclease H K03469,K06864 - 3.1.26.4 0.00000000000000000000000005665 117.0
HKD2_k127_4247401_0 DegT/DnrJ/EryC1/StrS aminotransferase family K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 578.0
HKD2_k127_4247401_1 FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 311.0
HKD2_k127_4247401_2 DsrE/DsrF-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000001396 223.0
HKD2_k127_4247401_3 homoserine kinase activity - - - 0.000000000000000000000000000003501 129.0
HKD2_k127_4247401_4 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000004645 109.0
HKD2_k127_4247401_5 Sulfurtransferase TusA - - - 0.00000000000000000000002028 101.0
HKD2_k127_4247401_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000001154 97.0
HKD2_k127_4247401_7 positive regulation of type IV pilus biogenesis K07343 - - 0.000000000000239 75.0
HKD2_k127_4247401_9 - - - - 0.00000006802 61.0
HKD2_k127_4265539_0 Heat shock 70 kDa protein K04043 - - 6.845e-242 755.0
HKD2_k127_4265539_1 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 407.0
HKD2_k127_4265539_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000001431 130.0
HKD2_k127_4282264_0 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000000000000000000016 173.0
HKD2_k127_4282264_1 3'-5' exonuclease activity K03547,K05970 - 3.1.1.53 0.000003531 54.0
HKD2_k127_4298270_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 335.0
HKD2_k127_4298270_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000001912 188.0
HKD2_k127_4298270_2 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000006096 132.0
HKD2_k127_4298270_3 Transcriptional regulator PadR-like family - - - 0.00000000006742 72.0
HKD2_k127_4304906_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 380.0
HKD2_k127_4304906_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 299.0
HKD2_k127_4304906_2 PFAM Major Facilitator Superfamily K19576 - - 0.00000000000000000000000000000000000000000000000000000000001361 220.0
HKD2_k127_4304906_3 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000001503 179.0
HKD2_k127_4304906_4 - - - - 0.0004604 43.0
HKD2_k127_4308097_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000002069 67.0
HKD2_k127_4321977_0 HELICc2 K03722,K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000004116 256.0
HKD2_k127_4321977_1 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000000000000007608 223.0
HKD2_k127_4321977_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000002032 219.0
HKD2_k127_4321977_3 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000002567 143.0
HKD2_k127_4325318_0 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 0.000000000000000000000000000000000000000000000000000000000000000000002048 241.0
HKD2_k127_4325318_1 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000004819 115.0
HKD2_k127_4328578_0 - - - - 0.000000000000000000000004867 105.0
HKD2_k127_4328578_1 Hydantoinase/oxoprolinase - - - 0.00000000000000000000009564 102.0
HKD2_k127_4328578_2 DGC domain protein - - - 0.0006514 50.0
HKD2_k127_4348068_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 443.0
HKD2_k127_4348068_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000002538 233.0
HKD2_k127_4388505_0 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000002228 152.0
HKD2_k127_439512_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 349.0
HKD2_k127_439512_1 Uncharacterized ArCR, COG1888 K09732 - - 0.000000000000000000000000000002326 122.0
HKD2_k127_439512_2 TIGRFAM phosphodiesterase, MJ0936 - - - 0.00000000000000006739 81.0
HKD2_k127_439512_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000003587 82.0
HKD2_k127_4416265_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 361.0
HKD2_k127_4418758_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000006899 228.0
HKD2_k127_4437872_0 Aminotransferase, class I - - - 0.00000000000000000000000000000000000000000000000001691 183.0
HKD2_k127_4437872_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000009669 128.0
HKD2_k127_4443072_0 COG0784 FOG CheY-like receiver - - - 0.00000000000000000000000000000000000000002859 169.0
HKD2_k127_4443072_1 PFAM Methyl-coenzyme M reductase K03421 - - 0.00000000000000000000000000000006889 125.0
HKD2_k127_4457499_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 510.0
HKD2_k127_4457499_1 Belongs to the MEMO1 family K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 302.0
HKD2_k127_4457499_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006997 297.0
HKD2_k127_4457499_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000001233 201.0
HKD2_k127_4457499_4 - - - - 0.000000009236 65.0
HKD2_k127_4485511_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 9.366e-204 644.0
HKD2_k127_4485511_1 ribosomal protein L15 K02876 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000002675 147.0
HKD2_k127_4485511_2 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000002527 91.0
HKD2_k127_4508021_0 peptidyl-prolyl cis-trans isomerase K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000001556 229.0
HKD2_k127_4508021_1 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000958 164.0
HKD2_k127_4517166_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000001145 229.0
HKD2_k127_4517166_1 Belongs to the UPF0248 family K09715 - - 0.000000000000007758 76.0
HKD2_k127_4523670_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 2.358e-209 666.0
HKD2_k127_4523670_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 470.0
HKD2_k127_4526929_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000008812 161.0
HKD2_k127_4526929_1 GrpB protein - - - 0.0000000000000000000000000000000001313 139.0
HKD2_k127_4536515_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 348.0
HKD2_k127_4536515_1 Isocitrate isopropylmalate dehydrogenase K05824 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0047046,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.87 0.0000000000000000000000001093 115.0
HKD2_k127_4581991_0 Calcineurin-like phosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000001302 189.0
HKD2_k127_4581991_1 Helix-turn-helix domain - - - 0.00000000000000004348 85.0
HKD2_k127_4581991_2 Universal stress protein family - - - 0.000006351 53.0
HKD2_k127_4590615_0 binding domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2.548e-238 752.0
HKD2_k127_4590615_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 327.0
HKD2_k127_4590615_2 maintenance of animal organ identity K05635,K19636 GO:0001654,GO:0001894,GO:0001895,GO:0001917,GO:0002139,GO:0002141,GO:0002142,GO:0003008,GO:0003674,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005604,GO:0005622,GO:0005623,GO:0005737,GO:0005815,GO:0005856,GO:0005886,GO:0005929,GO:0007275,GO:0007399,GO:0007423,GO:0007600,GO:0007605,GO:0008092,GO:0008104,GO:0008150,GO:0008544,GO:0009888,GO:0009913,GO:0009987,GO:0015630,GO:0016020,GO:0016324,GO:0017022,GO:0022008,GO:0030154,GO:0030182,GO:0030855,GO:0031012,GO:0031252,GO:0031253,GO:0031256,GO:0032391,GO:0032420,GO:0032421,GO:0032501,GO:0032502,GO:0032589,GO:0032991,GO:0033036,GO:0035315,GO:0035869,GO:0036064,GO:0042490,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043010,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043583,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045177,GO:0045184,GO:0045202,GO:0045494,GO:0045595,GO:0045596,GO:0046983,GO:0048496,GO:0048513,GO:0048519,GO:0048523,GO:0048699,GO:0048731,GO:0048839,GO:0048856,GO:0048869,GO:0048871,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050953,GO:0050954,GO:0051093,GO:0051179,GO:0051234,GO:0060041,GO:0060113,GO:0060171,GO:0060249,GO:0060429,GO:0062023,GO:0065007,GO:0065008,GO:0071944,GO:0097458,GO:0097730,GO:0097731,GO:0097733,GO:0098590,GO:0098858,GO:0098862,GO:0120025,GO:0120038,GO:1990075,GO:1990696 - 0.0002909 51.0
HKD2_k127_4626311_0 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000007213 250.0
HKD2_k127_4626311_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000002265 236.0
HKD2_k127_4626311_2 COG1522 Transcriptional regulators K03718 - - 0.0000000000000000000000000000000000001149 144.0
HKD2_k127_4641177_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 318.0
HKD2_k127_4641177_1 PFAM 4Fe-4S - - - 0.000000000000000000000000000000000000000000000000000000000000000000007131 243.0
HKD2_k127_4641177_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000003512 128.0
HKD2_k127_4641177_3 His Kinase A (phosphoacceptor) domain - - - 0.0000023 58.0
HKD2_k127_465719_0 Protein of unknown function (DUF1638) - - - 0.000000000000000004422 88.0
HKD2_k127_465719_1 - - - - 0.000000000003598 76.0
HKD2_k127_465719_2 - - - - 0.00007082 53.0
HKD2_k127_4672626_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 434.0
HKD2_k127_4672626_1 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0004311 48.0
HKD2_k127_4684970_0 aminopeptidase K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 501.0
HKD2_k127_4684970_1 Chloride channel - - - 0.000000000000000000000000000000000000000000000000000000007919 215.0
HKD2_k127_4684970_2 Sulfate transporter K03321 - - 0.0000000000000000000000000000000000000001263 161.0
HKD2_k127_4684970_3 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000004181 157.0
HKD2_k127_4684970_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000009412 160.0
HKD2_k127_4684970_5 Subtilase family - - - 0.00000000000000000000000000000000001824 155.0
HKD2_k127_4689168_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 468.0
HKD2_k127_4689168_1 Pfam:Methyltransf_26 K07446 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000001964 268.0
HKD2_k127_4689168_2 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000008388 172.0
HKD2_k127_4689168_3 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000246 164.0
HKD2_k127_4689168_4 - - - - 0.00000000001309 74.0
HKD2_k127_4689463_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000001256 174.0
HKD2_k127_4721576_0 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000001097 121.0
HKD2_k127_4721576_1 - - - - 0.00000000000000000000007462 106.0
HKD2_k127_4741629_0 Aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 460.0
HKD2_k127_4741629_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000001476 61.0
HKD2_k127_4751027_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 541.0
HKD2_k127_4751027_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 532.0
HKD2_k127_4751027_2 PAS domain - - - 0.000000000000000000000000000000000000000000000000000002196 212.0
HKD2_k127_4759642_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009233 441.0
HKD2_k127_4759642_1 Acyl-CoA reductase (LuxC) - - - 0.0001725 52.0
HKD2_k127_4800240_0 Helix-turn-helix XRE-family like proteins K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008164 260.0
HKD2_k127_4800240_1 Probable transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000003466 233.0
HKD2_k127_4800240_2 Probable transposase - - - 0.000000000000000443 83.0
HKD2_k127_4800240_3 metallopeptidase activity - - - 0.00003844 55.0
HKD2_k127_4804835_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 1.87e-275 860.0
HKD2_k127_4804835_1 Sodium/hydrogen exchanger family K03455 - - 0.00000000000000000004366 103.0
HKD2_k127_4820117_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000007402 230.0
HKD2_k127_4820117_1 Histidine kinase - - - 0.00000000001801 70.0
HKD2_k127_4820117_2 Phosphotransferase enzyme family - - - 0.0007555 45.0
HKD2_k127_4833748_0 ACT domain K09707 - - 0.00000000000000000000000000581 117.0
HKD2_k127_4833748_1 Conserved carboxylase domain K01571,K01960 - 4.1.1.3,6.4.1.1 0.00000000000000000000000009797 110.0
HKD2_k127_4833748_2 Biotin-requiring enzyme - - - 0.0000000000000002822 85.0
HKD2_k127_4833748_3 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000001674 62.0
HKD2_k127_4845724_0 Type II/IV secretion system protein K07332 - - 7.336e-216 689.0
HKD2_k127_4845724_1 Type II secretion system K07333 - - 0.0000000000000000005438 91.0
HKD2_k127_4862553_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000352 65.0
HKD2_k127_488026_0 Pfam:Kce K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 336.0
HKD2_k127_4932357_0 Glycosyltransferase like family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000005326 160.0
HKD2_k127_4934639_0 PQ loop repeat K15383 - - 0.0000000000000001257 82.0
HKD2_k127_4934639_1 Belongs to the SOS response-associated peptidase family - - - 0.0007322 46.0
HKD2_k127_4935295_0 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000009415 190.0
HKD2_k127_4935295_1 Translation initiation factor SUI1 K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001724 162.0
HKD2_k127_4935295_2 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000001855 154.0
HKD2_k127_4935295_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000002097 96.0
HKD2_k127_4935295_4 Ribosomal L29 protein K02904 - - 0.000000000000000003679 86.0
HKD2_k127_4951636_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 349.0
HKD2_k127_4951636_1 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000004549 95.0
HKD2_k127_4951655_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 367.0
HKD2_k127_4951655_1 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000000001704 185.0
HKD2_k127_4951655_2 TIGRFAM segregation and condensation protein B K06024 - - 0.000000000000000000000000000000000000001883 152.0
HKD2_k127_4951655_3 Transferase hexapeptide repeat K00966 - 2.7.7.13 0.00000000000000000000000000000000004817 138.0
HKD2_k127_4951655_4 snRNP Sm proteins K04796 - - 0.00000000000000000000004543 100.0
HKD2_k127_4954095_0 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000006148 169.0
HKD2_k127_4954095_1 - - - - 0.00000000000000000000001392 102.0
HKD2_k127_4954095_2 DNA polymerase beta domain protein region - - - 0.00000001217 62.0
HKD2_k127_4954095_3 EamA-like transporter family - - - 0.0000002478 62.0
HKD2_k127_4983644_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000003077 186.0
HKD2_k127_4983644_1 membrane - - - 0.00000000000000001656 91.0
HKD2_k127_4983782_0 DNA polymerase type-B family K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 618.0
HKD2_k127_4983782_1 GTPase of unknown function C-terminal K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000143 235.0
HKD2_k127_4987151_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 7.565e-229 716.0
HKD2_k127_4987151_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0000000000000002279 78.0
HKD2_k127_4996020_0 Putative exonuclease SbcCD, C subunit K03546 - - 0.0000000000000000000000000000000000000000011 163.0
HKD2_k127_4996020_1 methylase K00590 - 2.1.1.113 0.000105 52.0
HKD2_k127_5025867_0 COG0095 Lipoate-protein ligase A K03800 GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681 6.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000559 278.0
HKD2_k127_5025867_1 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000009684 175.0
HKD2_k127_5025867_2 - - - - 0.000000000007406 69.0
HKD2_k127_5025867_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000002227 70.0
HKD2_k127_5025867_4 Lipoate-protein ligase a K03800 - 6.3.1.20 0.00000000007074 66.0
HKD2_k127_5025867_5 PFAM Flavin reductase like domain - - - 0.000007772 53.0
HKD2_k127_5025867_6 - - - - 0.00003433 48.0
HKD2_k127_5025867_7 Redox-active disulfide protein - - - 0.0001514 48.0
HKD2_k127_5037242_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000004336 163.0
HKD2_k127_5072148_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 316.0
HKD2_k127_5072148_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000006097 118.0
HKD2_k127_5072148_2 transcriptional K07729 - - 0.00000000000000001425 84.0
HKD2_k127_5085543_0 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 333.0
HKD2_k127_5085543_1 HEAT repeat - - - 0.000000008116 62.0
HKD2_k127_508969_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 394.0
HKD2_k127_508969_1 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000004443 119.0
HKD2_k127_508969_2 Helix-hairpin-helix motif K07572 - - 0.0000000000000000000002902 97.0
HKD2_k127_508969_3 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000001398 86.0
HKD2_k127_508969_4 Fic/DOC family - - - 0.00001178 51.0
HKD2_k127_5093054_0 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 373.0
HKD2_k127_5093054_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K09163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006596 307.0
HKD2_k127_5093054_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 288.0
HKD2_k127_5093054_3 RNA polymerase subunit 9 K03057 - - 0.0000000000000000000000002493 108.0
HKD2_k127_5093054_4 - - - - 0.0001612 50.0
HKD2_k127_5105145_0 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 414.0
HKD2_k127_5105145_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000008365 69.0
HKD2_k127_5111232_0 Pyruvoyl-dependent arginine decarboxylase K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000009596 160.0
HKD2_k127_5111232_1 cheY-homologous receiver domain - - - 0.0000000000000000008076 96.0
HKD2_k127_5122615_0 Glycosyl Transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002412 279.0
HKD2_k127_5122615_1 GlcNAc-PI de-N-acetylase - - - 0.00000000005342 68.0
HKD2_k127_5132972_0 Chlorite dismutase - - - 0.00000000000000000001603 94.0
HKD2_k127_5133210_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000001358 191.0
HKD2_k127_5133210_1 Aminotransferase class-III K00821,K05830 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000007636 130.0
HKD2_k127_5133210_2 Aminotransferase class-III K00821,K05830 - 2.6.1.11,2.6.1.17 0.000002104 50.0
HKD2_k127_5135190_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000251 216.0
HKD2_k127_5135190_1 PFAM oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000002789 148.0
HKD2_k127_5141262_0 Protein of unknown function (DUF1847) - - - 0.0000000000000000000000000000000000000001256 158.0
HKD2_k127_5149223_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000001978 190.0
HKD2_k127_5149223_1 C4-dicarboxylate transporter malic acid transport protein K11041 - - 0.00000000000000000007464 92.0
HKD2_k127_5156802_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 322.0
HKD2_k127_5156802_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004983 259.0
HKD2_k127_5156802_2 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000000000001309 85.0
HKD2_k127_5158284_0 Leucine rich repeats (6 copies) - - - 0.00000000000000000000000000000000000000003646 163.0
HKD2_k127_5158284_1 Leucine rich repeats (6 copies) - - - 0.000000000000000000000000000005564 128.0
HKD2_k127_5177488_0 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000002669 160.0
HKD2_k127_5177488_1 Short repeat of unknown function (DUF308) - - - 0.0000000000000000009854 96.0
HKD2_k127_5193109_0 Possible Fer4-like domain in RNase L inhibitor, RLI K06174 - - 3.838e-247 788.0
HKD2_k127_5193109_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 503.0
HKD2_k127_5193109_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000000005176 132.0
HKD2_k127_5195589_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 377.0
HKD2_k127_5195589_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001134 258.0
HKD2_k127_5195589_2 - - - - 0.0000000000000000000000000000000000000000000000000000009492 196.0
HKD2_k127_5195589_3 TPR repeat - - - 0.00000000000000166 83.0
HKD2_k127_5219839_0 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000009764 163.0
HKD2_k127_5219839_1 Thioredoxin K03671 - - 0.00000000000000000000000000000001907 130.0
HKD2_k127_5219839_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000001625 113.0
HKD2_k127_5219839_3 PRC-barrel domain - - - 0.000000000000000000434 91.0
HKD2_k127_5219839_4 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000002255 84.0
HKD2_k127_5254213_0 helicase superfamily c-terminal domain K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 306.0
HKD2_k127_5268675_0 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 386.0
HKD2_k127_5282804_0 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000009136 177.0
HKD2_k127_5282804_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000006069 152.0
HKD2_k127_5282804_2 Methyltransferase domain K07579 - - 0.0000000000000009582 79.0
HKD2_k127_5299718_0 PFAM Hydantoinase oxoprolinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001188 287.0
HKD2_k127_5301521_0 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000005513 229.0
HKD2_k127_5301521_1 THUMP domain K06963 - - 0.0000001239 57.0
HKD2_k127_5307734_0 DNA polymerase alpha chain like domain - - - 0.0000000000000000000000000000000000000000000000000000005041 200.0
HKD2_k127_5307734_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.0000000000000000000000000004797 120.0
HKD2_k127_5321612_0 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 304.0
HKD2_k127_5321612_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003638 267.0
HKD2_k127_5321612_2 helicase superfamily c-terminal domain K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000004354 251.0
HKD2_k127_532672_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000003022 92.0
HKD2_k127_532672_1 RIO-like kinase K07178 - 2.7.11.1 0.000000000003277 71.0
HKD2_k127_5339820_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.645e-244 766.0
HKD2_k127_5339820_1 PRC-barrel domain - - - 0.00000000000000000000000000006571 117.0
HKD2_k127_5339820_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - 0.000000000001339 76.0
HKD2_k127_5339820_3 peptidyl-tyrosine sulfation - - - 0.00001418 50.0
HKD2_k127_5355656_0 Protein of unknown function (DUF1254) - - - 0.0000000000000000000000007866 109.0
HKD2_k127_5355656_1 PFAM membrane-flanked domain - - - 0.0000868 53.0
HKD2_k127_5356035_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000003272 214.0
HKD2_k127_5356035_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000002461 152.0
HKD2_k127_5356035_2 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.0000000000000000000000000000000002889 140.0
HKD2_k127_5356035_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000007235 59.0
HKD2_k127_5356306_0 ABC 3 transport family protein K09816 - - 0.0000000000000000002709 92.0
HKD2_k127_5356306_1 Radical SAM superfamily - - - 0.000000000000168 71.0
HKD2_k127_5356306_3 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.000002058 59.0
HKD2_k127_5360428_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000008439 174.0
HKD2_k127_5360428_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000122 50.0
HKD2_k127_5391841_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 536.0
HKD2_k127_5391841_1 Protein of unknown function (DUF835) - - - 0.00000002798 64.0
HKD2_k127_5396468_0 - - - - 0.000000000000005121 85.0
HKD2_k127_5396468_1 protein conserved in archaea K09746 - - 0.000000000002947 69.0
HKD2_k127_5412759_0 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 351.0
HKD2_k127_5431381_0 Belongs to the arginase family K01476 - 3.5.3.1 0.000000000000000000000000000000001271 138.0
HKD2_k127_5431381_1 Methyltransferase domain - - - 0.0000000000000000000000000001187 119.0
HKD2_k127_5434501_0 MAP kinase tyrosine/serine/threonine phosphatase activity K04459 GO:0000188,GO:0001704,GO:0001706,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007369,GO:0007492,GO:0008150,GO:0008152,GO:0008330,GO:0009653,GO:0009790,GO:0009888,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0012505,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0023051,GO:0023057,GO:0031090,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0033673,GO:0035335,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043412,GO:0043549,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045859,GO:0045936,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048598,GO:0048646,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0051019,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0140096,GO:1901564,GO:1902531,GO:1902532 3.1.3.16,3.1.3.48 0.000003531 54.0
HKD2_k127_5444179_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 341.0
HKD2_k127_5444179_1 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000002076 200.0
HKD2_k127_5444179_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000028 65.0
HKD2_k127_5451963_0 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000004064 226.0
HKD2_k127_5451963_1 PFAM Xylose isomerase domain protein TIM barrel K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000194 212.0
HKD2_k127_5451963_2 methyltransferase K21459 - 2.1.1.301 0.000000000000000000000000000000000000009305 155.0
HKD2_k127_5451963_3 Protein of unknown function (DUF835) K01937,K02488 - 2.7.7.65,6.3.4.2 0.000000000000000008135 95.0
HKD2_k127_5496087_0 - - - - 0.0006046 44.0
HKD2_k127_5521622_0 Protein of unknown function, DUF255 K06888 - - 7.221e-201 647.0
HKD2_k127_5521622_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 309.0
HKD2_k127_5521622_2 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 0.000000000000000000000000000000000000000000000000000000001152 203.0
HKD2_k127_5521622_3 Domain of unknown function (DUF4443) - - - 0.0000000000000000000000000000000000000000001164 166.0
HKD2_k127_5533635_0 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000006837 146.0
HKD2_k127_5533635_1 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000001709 117.0
HKD2_k127_5533635_2 regulatory protein, arsR - - - 0.0000000002706 70.0
HKD2_k127_5547756_0 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006986 285.0
HKD2_k127_5547756_1 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000003547 125.0
HKD2_k127_5547756_2 PFAM ApbE family K09740 - - 0.000729 44.0
HKD2_k127_5551807_0 NAD(P)H-dependent FMN reductase - - - 0.0000000000000000000003314 104.0
HKD2_k127_5551807_1 hydrogenase maturation protease K08315 - 3.4.23.51 0.000000000000000008642 88.0
HKD2_k127_5551807_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0001958 47.0
HKD2_k127_556031_0 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005702 254.0
HKD2_k127_556031_1 ASCH - - - 0.000000000000000000000000000000000000000004482 161.0
HKD2_k127_5562310_0 Protein of unknown function (DUF4011) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 452.0
HKD2_k127_5562310_1 Belongs to the eukaryotic ribosomal protein eL18 family K02883 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000001519 137.0
HKD2_k127_5573977_0 Alpha/beta hydrolase family K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 402.0
HKD2_k127_559010_0 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547,K05970 - 3.1.1.53 0.00000000000000000000000000000000000000000000000000000000000000005122 230.0
HKD2_k127_5600732_0 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 311.0
HKD2_k127_5600732_1 amino acid ABC transporter K02029 - - 0.00000000000000000000008111 100.0
HKD2_k127_5607662_0 PFAM peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 425.0
HKD2_k127_5609084_0 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000008591 145.0
HKD2_k127_5609084_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000008233 74.0
HKD2_k127_5617540_0 Major Facilitator Superfamily - - - 0.00000000000000000000176 99.0
HKD2_k127_5617540_1 PFAM DEAD_2 domain protein K10844 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0043139,GO:0048037,GO:0051276,GO:0051536,GO:0051539,GO:0051540,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.0000000000000000002918 100.0
HKD2_k127_5623268_0 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 367.0
HKD2_k127_5623268_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000001255 235.0
HKD2_k127_5623268_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000315 111.0
HKD2_k127_5630056_0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.000000000000000000000000000165 117.0
HKD2_k127_5630056_1 PFAM Acetyl-CoA hydrolase transferase - - - 0.0000000000000000000003296 99.0
HKD2_k127_56399_0 Peptidase family M28 - - - 0.000000000002783 78.0
HKD2_k127_5642079_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K03239,K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000006094 173.0
HKD2_k127_5642079_1 V4R K07013 - - 0.000000000000000000000000000000000000000000000822 174.0
HKD2_k127_5642079_2 NADPH-dependent FMN reductase - - - 0.000000000000007913 76.0
HKD2_k127_5666064_0 MMPL family K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 389.0
HKD2_k127_568083_0 Type II secretion system K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006593 248.0
HKD2_k127_568083_1 Type II secretion system K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002658 248.0
HKD2_k127_569436_0 DALR anticodon binding domain K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 353.0
HKD2_k127_569436_1 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.00000000000000000000000000000000002774 139.0
HKD2_k127_5697872_0 ABC transporter K00400,K16786,K16787 - - 2.52e-216 684.0
HKD2_k127_5697872_1 PFAM Methyl-coenzyme M reductase K03421 - - 0.000000000000000000000000000000000000000000000000000000007403 199.0
HKD2_k127_5697872_2 Domain of unknown function (DUF4443) - - - 0.00000000000000000000000000000000001353 142.0
HKD2_k127_5712602_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 399.0
HKD2_k127_5712602_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000125 291.0
HKD2_k127_5712602_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008364 275.0
HKD2_k127_5712602_3 COG1230 Co Zn Cd efflux system component K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000002224 238.0
HKD2_k127_5779385_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001939 231.0
HKD2_k127_5779385_1 Polysaccharide biosynthesis protein - - - 0.0003516 49.0
HKD2_k127_5800095_0 Protein of unknown function (DUF998) - - - 0.000000000000000000000000000000007194 131.0
HKD2_k127_5800095_1 SMART Elongator protein 3 MiaB NifB K13602 - 2.1.1.331 0.000006925 54.0
HKD2_k127_5825458_0 Double zinc ribbon - - - 0.0000000000000000000000000000000000000000003688 183.0
HKD2_k127_5826577_0 AAA ATPase domain - - - 0.0000000000000001197 87.0
HKD2_k127_5831891_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000009333 271.0
HKD2_k127_5831891_1 BioY family K03523 - - 0.0000000000000000001412 94.0
HKD2_k127_5831891_2 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.00001032 50.0
HKD2_k127_5865038_0 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 0.00000000000003939 78.0
HKD2_k127_5865038_1 drug exporters of the RND superfamily - - - 0.0003958 52.0
HKD2_k127_5867420_0 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000008727 99.0
HKD2_k127_5867420_1 methylase K00590 - 2.1.1.113 0.00000000003165 74.0
HKD2_k127_5883051_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 312.0
HKD2_k127_5883051_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001271 234.0
HKD2_k127_5883051_2 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000001487 169.0
HKD2_k127_5883051_3 Redox-active disulfide protein - - - 0.0007497 46.0
HKD2_k127_5894240_0 helix_turn_helix, Lux Regulon K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001731 255.0
HKD2_k127_5894240_1 ATP-binding region ATPase domain protein K07675 - 2.7.13.3 0.000000000000000003467 88.0
HKD2_k127_5910911_0 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000447 161.0
HKD2_k127_5920254_0 PFAM ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 343.0
HKD2_k127_5920254_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000003467 203.0
HKD2_k127_5920254_2 Protein of unknown function (DUF521) K09123 - - 0.0000000000002465 80.0
HKD2_k127_5920254_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000001377 63.0
HKD2_k127_5920254_4 2Fe-2S iron-sulfur cluster binding domain K00302 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1 0.0000562 55.0
HKD2_k127_5938207_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 327.0
HKD2_k127_5938207_1 Transcriptional regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000001289 136.0
HKD2_k127_5938207_2 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000006257 131.0
HKD2_k127_5943930_0 AAA domain K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 411.0
HKD2_k127_5988059_0 Putative modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 318.0
HKD2_k127_5988059_1 PP-loop domain protein K06864 - - 0.0000000000000000000000003394 107.0
HKD2_k127_6011658_0 FAD binding domain K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000623 180.0
HKD2_k127_6011658_1 Formyl transferase K11175 - 2.1.2.2 0.000000000000000000000000000000000000001044 155.0
HKD2_k127_6011658_2 - - - - 0.000000000000000000000000000000001241 132.0
HKD2_k127_6014210_0 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 1.419e-289 898.0
HKD2_k127_6028797_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.311e-215 685.0
HKD2_k127_6028797_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 338.0
HKD2_k127_6028797_2 DEAD DEAH box helicase domain protein K10896 - - 0.0000000000000000000000000002812 116.0
HKD2_k127_6028797_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000002406 76.0
HKD2_k127_6032471_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 409.0
HKD2_k127_6032471_1 Thiamine-binding protein - - - 0.000000000000000003509 87.0
HKD2_k127_6032471_2 - - - - 0.00000000000000001974 86.0
HKD2_k127_603254_0 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 354.0
HKD2_k127_6034054_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 342.0
HKD2_k127_6034054_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000009635 168.0
HKD2_k127_6034054_2 LysE type translocator - - - 0.000000000000000000000000000000000000001927 155.0
HKD2_k127_6034054_3 PFAM Rieske 2Fe-2S domain K05710 - - 0.0000000000000000000000165 103.0
HKD2_k127_6034054_4 Glutaredoxin - - - 0.00000000000000000000004688 100.0
HKD2_k127_6034054_5 PFAM Rieske 2Fe-2S domain K05710 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000003068 99.0
HKD2_k127_6034054_6 - - - - 0.0000000001112 64.0
HKD2_k127_6036381_0 GXGXG motif - - - 3.972e-244 777.0
HKD2_k127_6036381_1 Glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 591.0
HKD2_k127_6036381_2 Nitrite and sulphite reductase 4Fe-4S - - - 0.0000000000000000000000000000000000000003173 157.0
HKD2_k127_6052888_0 Glycosyl transferase family group 2 - - - 0.00000000000000000000002872 109.0
HKD2_k127_6052888_1 PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain K02472 - 1.1.1.336 0.0000000000002651 72.0
HKD2_k127_6053816_0 COG3407 Mevalonate pyrophosphate decarboxylase K17942 - 4.1.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008769 279.0
HKD2_k127_6053816_1 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000004472 77.0
HKD2_k127_6065297_0 Prenyltransferase and squalene oxidase repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002505 267.0
HKD2_k127_6065297_1 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000003021 173.0
HKD2_k127_6065297_2 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000001734 124.0
HKD2_k127_6065297_3 O-methyltransferase - - - 0.000000000000000000000003352 106.0
HKD2_k127_6065297_4 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000004506 97.0
HKD2_k127_6084777_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000153 250.0
HKD2_k127_6112102_0 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000001123 143.0
HKD2_k127_6112102_1 Glyoxalase-like domain K06996 - - 0.0000000000000000000001575 101.0
HKD2_k127_6112102_2 amidohydrolase K07045 - - 0.000000000000000000001806 103.0
HKD2_k127_6112102_3 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000003898 82.0
HKD2_k127_6116023_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601,K08965 - 4.1.1.39,5.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 484.0
HKD2_k127_6158253_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 292.0
HKD2_k127_6158253_1 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008268 286.0
HKD2_k127_6158253_2 Domain of unknown function (DUF4445) - - - 0.000000000000000000000000000000000000000000000000001629 186.0
HKD2_k127_6158253_3 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000001191 163.0
HKD2_k127_6164171_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 323.0
HKD2_k127_6164171_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.000000000001084 72.0
HKD2_k127_6202709_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 443.0
HKD2_k127_6202709_1 TIGRFAM Ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 414.0
HKD2_k127_6202709_2 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000001089 240.0
HKD2_k127_6202709_3 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000007989 133.0
HKD2_k127_6202709_4 DGC domain - - - 0.0000000000000000000001473 102.0
HKD2_k127_6202709_5 metal-dependent phosphoesterases (PHP family) - - - 0.000000000000005775 81.0
HKD2_k127_6205674_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 432.0
HKD2_k127_6205674_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.000000000000000006689 87.0
HKD2_k127_6216777_0 CBS domain - - - 0.000000000000000000000000000000000000000000000005849 178.0
HKD2_k127_6216777_1 DNA-binding transcription factor activity - - - 0.0005883 50.0
HKD2_k127_6219370_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 489.0
HKD2_k127_6219370_1 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000004097 176.0
HKD2_k127_6219370_2 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K18816 - 2.3.1.82 0.00006046 46.0
HKD2_k127_6249267_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000004874 139.0
HKD2_k127_6249267_1 cobalamin synthesis protein - - - 0.0000000008313 66.0
HKD2_k127_6260317_0 MGS-like domain K00602,K01492 - 2.1.2.2,2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 513.0
HKD2_k127_6260317_1 Cation efflux family K16264 - - 0.0000000000000000000000000000000000000002356 154.0
HKD2_k127_6283071_0 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 369.0
HKD2_k127_6283071_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000012 276.0
HKD2_k127_6283071_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006071 259.0
HKD2_k127_6283071_3 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.000000000000000000000000000000000000000000000000000000000000000003085 231.0
HKD2_k127_6283071_4 cobalamin binding - - - 0.00000000000000000000000000000000000000001866 161.0
HKD2_k127_6283071_5 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000004244 137.0
HKD2_k127_6283071_6 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000006955 113.0
HKD2_k127_6283071_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.215,2.1.1.216 0.000000000000004511 78.0
HKD2_k127_6286511_0 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 297.0
HKD2_k127_6286511_1 nucleotide catabolic process K01081,K11751 - 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000003165 216.0
HKD2_k127_6321403_0 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000001401 155.0
HKD2_k127_6321403_1 ATPase associated with various cellular activities K03924 - - 0.000000000000000000000000002506 112.0
HKD2_k127_6325359_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 530.0
HKD2_k127_6325359_1 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000001798 201.0
HKD2_k127_6360041_0 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000001275 214.0
HKD2_k127_6360041_1 FMN binding - - - 0.00000002231 62.0
HKD2_k127_6360041_2 Dinitrogenase iron-molybdenum cofactor - - - 0.0004302 48.0
HKD2_k127_6364702_0 GvpD gas vesicle protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006678 246.0
HKD2_k127_6364702_1 MgtC family - - - 0.000000000000000000000000000000000000000000000000000000001099 217.0
HKD2_k127_6364702_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000007032 157.0
HKD2_k127_6364702_3 PFAM phosphatidate cytidylyltransferase K18678 - 2.7.1.182 0.000000000000000000000000000000000003038 147.0
HKD2_k127_6364702_4 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000002428 139.0
HKD2_k127_6364702_5 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000006636 68.0
HKD2_k127_6372331_0 Proton-conducting membrane transporter K22169 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 362.0
HKD2_k127_6372331_1 Proton-conducting membrane transporter K00342,K22168 - 1.5.98.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 353.0
HKD2_k127_6372642_0 Rad51 - - - 0.00000000000000000000000000000000000000000000499 172.0
HKD2_k127_6372642_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00002081 56.0
HKD2_k127_6376630_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 380.0
HKD2_k127_6376630_1 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000005335 196.0
HKD2_k127_6376630_2 Uroporphyrinogen decarboxylase (URO-D) K14082 - 2.1.1.247 0.000000000000000000000000000000000000000000000000000000734 205.0
HKD2_k127_6376630_3 COG1335 Amidases related to nicotinamidase - - - 0.000000000000000000000000000000000000000001238 162.0
HKD2_k127_6378104_0 DEAD/H associated K03724 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 422.0
HKD2_k127_6378104_1 DEAD/H associated K03724 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 357.0
HKD2_k127_6386458_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000003118 160.0
HKD2_k127_6386458_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000009755 132.0
HKD2_k127_6386458_2 PFAM dihydropteroate synthase, DHPS K15023 - 2.1.1.258 0.00000000000000000000000007655 110.0
HKD2_k127_638906_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 505.0
HKD2_k127_638906_1 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000001911 247.0
HKD2_k127_638906_2 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000006897 173.0
HKD2_k127_638906_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000001425 108.0
HKD2_k127_6398051_0 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001206 236.0
HKD2_k127_6398051_1 Helix-turn-helix domain - - - 0.000000000000005105 81.0
HKD2_k127_6398051_2 Helix-turn-helix domain - - - 0.000001312 55.0
HKD2_k127_6398051_3 PFAM GvpD gas vesicle - - - 0.0005507 48.0
HKD2_k127_6404644_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000003969 264.0
HKD2_k127_6404644_1 PFAM Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002592 251.0
HKD2_k127_6404644_2 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000001954 138.0
HKD2_k127_6404644_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000006473 55.0
HKD2_k127_640569_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000202 178.0
HKD2_k127_6416614_0 Predicted membrane protein (DUF2085) - - - 0.00000000000000000000008975 104.0
HKD2_k127_6416614_1 formylmethanofuran dehydrogenase, subunit E - - - 0.0000000000000000001398 94.0
HKD2_k127_6416614_2 - - - - 0.000000000002801 74.0
HKD2_k127_6416614_3 - - - - 0.000000002488 69.0
HKD2_k127_6417746_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008173 292.0
HKD2_k127_6417746_1 - - - - 0.0000000000000000000000000000000000002896 147.0
HKD2_k127_6423192_0 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 360.0
HKD2_k127_6423192_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000004981 230.0
HKD2_k127_6423192_2 Rubrerythrin - - - 0.00000343 59.0
HKD2_k127_6427859_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000892 209.0
HKD2_k127_6427859_1 Peptidase family M28 K01439 - 3.5.1.18 0.000000000000000000000000000000619 134.0
HKD2_k127_6430657_0 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000262 169.0
HKD2_k127_6430657_1 AAA domain - - - 0.0000000000000000000000000000000000000000002531 170.0
HKD2_k127_6442250_0 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 301.0
HKD2_k127_6442250_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000003745 240.0
HKD2_k127_6442250_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000000000000000001913 99.0
HKD2_k127_6451394_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 357.0
HKD2_k127_6451394_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000003558 248.0
HKD2_k127_6451394_2 Protein of unknown function (DUF3052) - - - 0.000000000000000000000002759 107.0
HKD2_k127_6451394_3 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.000000000009157 67.0
HKD2_k127_6451394_4 AMP binding - - - 0.00000006821 57.0
HKD2_k127_6451871_0 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001295 240.0
HKD2_k127_6451871_1 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000003907 81.0
HKD2_k127_6452423_0 Mu-like prophage FluMu protein gp28 - - - 0.000000000000000000004429 102.0
HKD2_k127_6463155_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 472.0
HKD2_k127_6463155_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 395.0
HKD2_k127_6463155_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0004353 51.0
HKD2_k127_6475134_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 427.0
HKD2_k127_6475134_1 PFAM Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 292.0
HKD2_k127_6475134_2 PFAM BioY K03523 - - 0.0002115 47.0
HKD2_k127_6478207_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000009215 165.0
HKD2_k127_6478207_1 membrane - - - 0.000000009444 65.0
HKD2_k127_6479587_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 453.0
HKD2_k127_6479587_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000003397 186.0
HKD2_k127_6479587_2 - - - - 0.00000000000000001301 85.0
HKD2_k127_6479587_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025,K08723 - 3.1.3.5 0.0000000000000001247 83.0
HKD2_k127_6485096_0 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000006958 126.0
HKD2_k127_6485096_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000973 105.0
HKD2_k127_6486492_0 TIGRFAM iron-sulfur cluster binding protein K18979 - 1.17.99.6 0.0000000000000000000000000000000000000003312 160.0
HKD2_k127_6486492_1 Nitroreductase family - - - 0.00000000000000000000001825 102.0
HKD2_k127_6491495_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002684 262.0
HKD2_k127_6491495_1 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000000000000128 99.0
HKD2_k127_6491495_2 PFAM thioesterase superfamily K02614 - - 0.0000000000000003113 85.0
HKD2_k127_6491495_3 PFAM Rhodanese domain protein - - - 0.0000000000000003783 82.0
HKD2_k127_6491495_4 ABC-2 family transporter protein K01992 - - 0.0000000000000277 82.0
HKD2_k127_6498260_0 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000032 276.0
HKD2_k127_6498260_1 ABC-2 type transporter K01992 - - 0.00000000001693 70.0
HKD2_k127_6502319_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 564.0
HKD2_k127_6502319_1 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 308.0
HKD2_k127_6502319_2 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 293.0
HKD2_k127_6502319_3 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000002841 238.0
HKD2_k127_6502319_4 Ion channel K10716 - - 0.0000000000000000000000000000000000000009831 160.0
HKD2_k127_6512342_0 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008602 417.0
HKD2_k127_6512342_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 309.0
HKD2_k127_6518448_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000002998 164.0
HKD2_k127_6518448_1 Belongs to the phosphoglycerate kinase family K00927 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 0.000000000000000000000000008038 112.0
HKD2_k127_6521483_0 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 333.0
HKD2_k127_6521483_1 Phosphoribosyl transferase domain K00769,K07101 - 2.4.2.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000001118 263.0
HKD2_k127_6521483_2 ABC-2 family transporter protein K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002235 260.0
HKD2_k127_6521483_3 May catalyze a purine salvage reaction, the substrate is K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000005919 207.0
HKD2_k127_6521483_4 Rieske-like [2Fe-2S] domain K05710,K14578,K14750 - - 0.000000000000000004201 88.0
HKD2_k127_6531417_0 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003211 287.0
HKD2_k127_6531417_1 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000002845 193.0
HKD2_k127_6536128_0 cation diffusion facilitator family transporter - - - 0.000000000000000000006354 102.0
HKD2_k127_6536128_1 PFAM PspC domain protein - - - 0.0000002776 61.0
HKD2_k127_6570594_0 DHH family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 313.0
HKD2_k127_6570594_1 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0016272,GO:0022607,GO:0032991,GO:0034622,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051087,GO:0051131,GO:0065003,GO:0071840 - 0.00000000000000001687 85.0
HKD2_k127_6570594_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000009124 82.0
HKD2_k127_6571654_0 Bacterial Na+/H+ antiporter B (NhaB) K03893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001201 261.0
HKD2_k127_6571654_1 Nucleolar GTP-binding protein 1 (NOG1) K06943 - - 0.000000000000000000000000000000000000000000000000004402 189.0
HKD2_k127_6571654_2 Bacterial regulatory helix-turn-helix protein, lysR family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000002239 180.0
HKD2_k127_6571654_3 helix_turn_helix ASNC type K03718 - - 0.0000000000000000000000006451 109.0
HKD2_k127_657646_0 PFAM Bile acid sodium symporter K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 416.0
HKD2_k127_657646_2 - - - - 0.00002225 51.0
HKD2_k127_657646_3 membrane-associated protein domain - - - 0.000031 53.0
HKD2_k127_660463_0 Uroporphyrinogen decarboxylase (URO-D) K14082 - 2.1.1.247 0.0000000000000000000000000000000000000000000000002858 189.0
HKD2_k127_660463_1 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000617 126.0
HKD2_k127_6607817_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 464.0
HKD2_k127_6625179_0 Methanol-cobalamin methyltransferase B subunit K04480 - 2.1.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 541.0
HKD2_k127_6625179_1 corrinoid protein K14081 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003203 269.0
HKD2_k127_6633428_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 456.0
HKD2_k127_6633428_1 Cysteine desulfurase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 446.0
HKD2_k127_6633428_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 372.0
HKD2_k127_6633428_3 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 342.0
HKD2_k127_6633428_4 - - - - 0.00000000000000003305 87.0
HKD2_k127_6633428_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000003663 81.0
HKD2_k127_6633428_6 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.000000000821 62.0
HKD2_k127_6633428_7 - - - - 0.00000001734 63.0
HKD2_k127_6640888_0 Sulfate transporter K03321 - - 0.000000000000000000000000000000000000000000000000001639 195.0
HKD2_k127_6640888_1 PFAM SOUL heme-binding protein - - - 0.0000000000000000000000000000000000000009689 154.0
HKD2_k127_6640888_2 Protoporphyrinogen oxidase K00230 GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.3 0.00002466 51.0
HKD2_k127_6647379_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 439.0
HKD2_k127_6647379_1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00001286 48.0
HKD2_k127_6662127_0 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.000001573 57.0
HKD2_k127_6662127_1 Helix-turn-helix domain - - - 0.00002499 52.0
HKD2_k127_6662127_2 - - - - 0.0001307 48.0
HKD2_k127_6670908_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 508.0
HKD2_k127_6670908_1 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.257 0.00000000000000000000000000000001275 128.0
HKD2_k127_6712823_0 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 515.0
HKD2_k127_6712823_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000005463 223.0
HKD2_k127_6713231_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007762 346.0
HKD2_k127_6713231_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 329.0
HKD2_k127_6713231_2 DHH family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 317.0
HKD2_k127_6713231_3 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 301.0
HKD2_k127_6713231_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 297.0
HKD2_k127_6713231_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 286.0
HKD2_k127_6713231_6 binds to the 23S rRNA K02921 - - 0.000000000000000000000000005843 112.0
HKD2_k127_6713231_7 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0008150,GO:0009987,GO:0016043,GO:0016272,GO:0022607,GO:0032991,GO:0034622,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051087,GO:0051131,GO:0065003,GO:0071840 - 0.00000000000005015 76.0
HKD2_k127_6713231_8 DNA directed RNA polymerase, 7 kDa subunit K03059 - 2.7.7.6 0.0000000001623 62.0
HKD2_k127_6713231_9 Transcription factor Pcc1 K09741 - - 0.000000001123 62.0
HKD2_k127_6735771_0 Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001684 254.0
HKD2_k127_6735771_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000003215 218.0
HKD2_k127_6740721_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.00000000000005742 81.0
HKD2_k127_6740721_1 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000123 71.0
HKD2_k127_6779482_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 389.0
HKD2_k127_6779482_1 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 346.0
HKD2_k127_6779482_2 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K07575 - - 0.0000000000000000000000000000000000000000000000000008554 188.0
HKD2_k127_6779482_3 Pfam:DUF552 K09152 - - 0.00000000000000000000000164 107.0
HKD2_k127_6789648_0 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000002048 211.0
HKD2_k127_6789648_1 heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000108 119.0
HKD2_k127_6802599_0 LemA family K03744 - - 0.000000000000007397 77.0
HKD2_k127_6802599_1 TPM domain K06872 - - 0.0000000001367 71.0
HKD2_k127_6802599_2 Nitroreductase family - - - 0.0000000004214 66.0
HKD2_k127_6822790_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.000000000000000000000000002949 114.0
HKD2_k127_6822790_1 COGs COG4591 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000001163 116.0
HKD2_k127_6825735_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.000000000000000000000000000000000000000000000000000000000000000002101 239.0
HKD2_k127_6825735_1 Circadian clock protein K08482 - - 0.00003012 50.0
HKD2_k127_6826472_0 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008973 264.0
HKD2_k127_6826472_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000008018 150.0
HKD2_k127_6831260_0 formylmethanofuran dehydrogenase, subunit E - - - 0.0000000000000000003934 93.0
HKD2_k127_6831260_1 - - - - 0.0000402 53.0
HKD2_k127_6884110_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000007996 270.0
HKD2_k127_6884110_1 Pfam:KaiC - - - 0.00000000000000000002966 94.0
HKD2_k127_6889325_0 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000004044 246.0
HKD2_k127_6918436_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 545.0
HKD2_k127_6918436_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 512.0
HKD2_k127_6918436_2 6,7-dimethyl-8-ribityllumazine synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000002134 245.0
HKD2_k127_6918436_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000001235 188.0
HKD2_k127_6918436_4 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.000000000000000000000000001893 114.0
HKD2_k127_6924126_0 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 297.0
HKD2_k127_6934372_0 Pas domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008036 249.0
HKD2_k127_6939495_0 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000003673 228.0
HKD2_k127_6939495_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000001971 184.0
HKD2_k127_6939495_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000003306 151.0
HKD2_k127_6943588_0 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001494 258.0
HKD2_k127_6943588_1 PIN domain - - - 0.0000000000000000000001126 110.0
HKD2_k127_6943588_2 - - - - 0.00003002 48.0
HKD2_k127_6950615_0 ABC-type Fe3 transport system permease component K02053,K02054,K02063 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008644 488.0
HKD2_k127_6950615_1 MobA-like NTP transferase domain K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000391 183.0
HKD2_k127_695082_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000001507 115.0
HKD2_k127_695082_1 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000001602 96.0
HKD2_k127_695082_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.0000000000957 67.0
HKD2_k127_695082_3 RNA-binding protein containing KH domain possibly ribosomal protein K07574 - - 0.000000004841 61.0
HKD2_k127_7013564_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000004452 178.0
HKD2_k127_7013564_1 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000007475 127.0
HKD2_k127_7013564_2 - - - - 0.00002639 50.0
HKD2_k127_7019743_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 467.0
HKD2_k127_7019743_1 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.00000000000000000000000000000000000000009195 154.0
HKD2_k127_7020764_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000346 255.0
HKD2_k127_7020764_1 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.00000000000000000000000000483 119.0
HKD2_k127_7026766_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 349.0
HKD2_k127_7026766_1 flavin reductase - - - 0.000000000000000000000000000000000001439 145.0
HKD2_k127_7026766_2 flavin reductase - - - 0.0000000000000000000000000006901 119.0
HKD2_k127_7026766_3 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000001303 83.0
HKD2_k127_7026766_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000001173 63.0
HKD2_k127_7026766_5 GlcNAc-PI de-N-acetylase - - - 0.000000004544 66.0
HKD2_k127_7033664_0 flavodoxin nitric oxide synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 375.0
HKD2_k127_7033664_1 SNARE associated Golgi protein K01077 - 3.1.3.1 0.0000002518 54.0
HKD2_k127_7034466_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002252 276.0
HKD2_k127_7034466_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008292 266.0
HKD2_k127_7034466_2 SpoU rRNA Methylase family - - - 0.0000000000000000000000000000000000000000008816 159.0
HKD2_k127_7034466_3 Ribbon-helix-helix protein, copG family K07722 - - 0.000000000000000000004939 96.0
HKD2_k127_7034466_4 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000004489 54.0
HKD2_k127_7039624_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 306.0
HKD2_k127_7042607_0 ABC transporter K02010,K02017,K02052,K02062,K10112,K11072,K15497,K17240 - 3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 329.0
HKD2_k127_7042607_1 ABC-type Fe3 transport system permease component K02053,K02054,K02063 - - 0.00000000000000000000000000000000000006091 146.0
HKD2_k127_7051039_0 Phosphomethylpyrimidine kinase K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000001965 258.0
HKD2_k127_7051039_1 Glycosyltransferase, group 1 family protein - - - 0.0000002265 54.0
HKD2_k127_7051237_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006009 268.0
HKD2_k127_7051237_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000002201 233.0
HKD2_k127_7053100_0 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 341.0
HKD2_k127_7053100_1 Transport permease protein K01992 - - 0.0000003116 53.0
HKD2_k127_7054365_0 helicase superfamily c-terminal domain K05592,K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 434.0
HKD2_k127_7084590_0 Amino acid kinase family K00928,K12524 - 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 329.0
HKD2_k127_7084590_1 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000001736 269.0
HKD2_k127_7085529_0 NAD(P)H dehydrogenase (quinone) activity - - - 0.00000000000000000000000000000000000000000000000000000001193 203.0
HKD2_k127_7085529_1 Uroporphyrinogen decarboxylase (URO-D) K14082 - 2.1.1.247 0.0000000000000000000000000000000000000000000000000000002705 207.0
HKD2_k127_7085529_2 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000005416 141.0
HKD2_k127_7095205_0 Glycosyltransferase Family 4 - - - 0.000000000265 70.0
HKD2_k127_7095205_1 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0004491 53.0
HKD2_k127_7100864_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 441.0
HKD2_k127_7105322_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009451 600.0
HKD2_k127_7121053_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007237 276.0
HKD2_k127_7121053_1 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000003485 240.0
HKD2_k127_7121053_2 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000003251 171.0
HKD2_k127_7121053_3 ABC transporter K01990 - - 0.00001017 47.0
HKD2_k127_7137863_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002568 253.0
HKD2_k127_7137863_1 May be involved in maturation of the 30S ribosomal subunit K02966 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000008376 199.0
HKD2_k127_7137863_2 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904 - 0.000000000000000000000000000000000000000000000000001367 194.0
HKD2_k127_7137863_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 0.0000000000000000000000509 100.0
HKD2_k127_7137863_4 Belongs to the PDCD5 family K06875 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000008262 104.0
HKD2_k127_7137863_5 Belongs to the ribosomal protein L31e family K02910 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000004145 95.0
HKD2_k127_7137863_6 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.000000000000001105 77.0
HKD2_k127_7152243_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 404.0
HKD2_k127_7152243_1 LD-carboxypeptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000000000007211 260.0
HKD2_k127_7161821_0 Belongs to the universal ribosomal protein uL16 family K02866 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000104 190.0
HKD2_k127_7161821_1 Putative diphthamide synthesis protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000003007 167.0
HKD2_k127_7162256_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 1.317e-251 797.0
HKD2_k127_7196321_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 9.612e-206 662.0
HKD2_k127_7196321_1 COG0857 BioD-like N-terminal domain of phosphotransacetylase K06873 - - 0.000000000000000000000000000000000000000000000000000000000000000000009772 243.0
HKD2_k127_7196321_2 Nucleic acid binding K03698 - - 0.0000000000000000000000000000000000000000000000000000000003563 214.0
HKD2_k127_7196321_3 Metal-dependent hydrolase - - - 0.000000000000000000000000000000000000408 148.0
HKD2_k127_7196321_4 - - - - 0.000000000003798 78.0
HKD2_k127_7200505_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000001163 154.0
HKD2_k127_7200505_1 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000003482 59.0
HKD2_k127_7228599_0 AAA domain - - - 0.00000000000000000000000000000000000000000000006028 187.0
HKD2_k127_7228599_1 Protein of unknown function (DUF835) K01937,K02488 - 2.7.7.65,6.3.4.2 0.000000000004168 74.0
HKD2_k127_7230309_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 434.0
HKD2_k127_7230309_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001878 240.0
HKD2_k127_7230309_2 Phospholipase D. Active site motifs. - - - 0.000000003743 64.0
HKD2_k127_7239780_0 ATPases associated with a variety of cellular activities K10112,K17240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 388.0
HKD2_k127_7239780_1 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000006867 145.0
HKD2_k127_7239780_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.000006756 54.0
HKD2_k127_7257353_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 5.101e-320 992.0
HKD2_k127_7257353_1 transcriptional - - - 0.000000000000000000000000000000000004986 144.0
HKD2_k127_7257353_2 Belongs to the small heat shock protein (HSP20) family K06335,K13993 - - 0.000000000000000448 84.0
HKD2_k127_7262022_0 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000003063 65.0
HKD2_k127_7262871_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000007899 157.0
HKD2_k127_7271749_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000009296 123.0
HKD2_k127_7306100_0 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000006934 250.0
HKD2_k127_7306100_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000001026 101.0
HKD2_k127_7310404_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 504.0
HKD2_k127_7340869_0 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000006262 223.0
HKD2_k127_7340869_1 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000169 144.0
HKD2_k127_7340869_2 Double zinc ribbon - - - 0.00000000000007287 81.0
HKD2_k127_7340869_3 OmpA family - - - 0.0000000009441 69.0
HKD2_k127_735057_0 PEP-utilising enzyme, mobile domain K01006,K01007 - 2.7.9.1,2.7.9.2 2.35e-313 976.0
HKD2_k127_735057_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169,K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 452.0
HKD2_k127_735057_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 426.0
HKD2_k127_735057_3 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008977 308.0
HKD2_k127_735057_4 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K00189 - 1.2.7.1,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000001573 224.0
HKD2_k127_735057_5 Radical SAM domain protein - - - 0.000000000000000000000000000000000000002618 155.0
HKD2_k127_735057_6 pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000006052 131.0
HKD2_k127_735057_7 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000003221 116.0
HKD2_k127_735057_8 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.0000000000000000000001113 100.0
HKD2_k127_735057_9 CBS domain - - - 0.00006381 46.0
HKD2_k127_7359727_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000001 210.0
HKD2_k127_7380275_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 596.0
HKD2_k127_7383633_0 ROK family K00845,K13967,K19979,K20433 - 2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 436.0
HKD2_k127_7386838_0 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000009579 179.0
HKD2_k127_7386838_1 - - - - 0.00000000000000000000008058 106.0
HKD2_k127_7386838_2 Methionine biosynthesis protein MetW - - - 0.00000000000003669 81.0
HKD2_k127_7392332_0 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 441.0
HKD2_k127_7392332_1 prephenate dehydrogenase K04517,K14170,K14187 - 1.3.1.12,4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000004745 227.0
HKD2_k127_7392332_2 Homocysteine biosynthesis enzyme, sulfur-incorporation - - - 0.000000000001898 68.0
HKD2_k127_7392332_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000006489 53.0
HKD2_k127_7407245_0 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 332.0
HKD2_k127_7407245_1 PFAM NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000003001 164.0
HKD2_k127_7448103_0 COG3119 Arylsulfatase A and related enzymes K01130 - 3.1.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 601.0
HKD2_k127_747263_0 Sulfatase K01130 - 3.1.6.1 0.0000000000000000000000000000000000000007616 150.0
HKD2_k127_747263_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000006943 77.0
HKD2_k127_747263_2 Glycosyltransferase like family 2 - - - 0.00000000001145 68.0
HKD2_k127_7478814_0 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1140.0
HKD2_k127_7486841_0 General secretory system II protein E domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 515.0
HKD2_k127_7486841_1 Tfp pilus assembly protein FimV - - - 0.0002294 44.0
HKD2_k127_753829_0 Belongs to the peptidase M16 family - - - 0.00000000000000000003019 98.0
HKD2_k127_753829_1 Acetyltransferase (GNAT) family - - - 0.00001941 55.0
HKD2_k127_7552393_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 344.0
HKD2_k127_7552393_1 4Fe-4S single cluster domain K07129 - - 0.0000000000000000000000000000000000000000000000000000000000009292 216.0
HKD2_k127_7552393_2 Participates in transcription termination K02600 - - 0.000000000000000000000000000000000000000000000000000000001663 203.0
HKD2_k127_7552393_3 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000108 120.0
HKD2_k127_7563875_0 SPFH domain-Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 501.0
HKD2_k127_7563875_1 - - - - 0.000000000000000000000000000000000004421 139.0
HKD2_k127_7586063_0 dUTPase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000001338 181.0
HKD2_k127_7586063_1 signal transduction histidine kinase - - - 0.0000000000000000001772 101.0
HKD2_k127_7586063_2 Met-10+ like-protein K15429 - 2.1.1.228 0.000000009497 59.0
HKD2_k127_7605990_0 Leucine rich repeats (6 copies) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 357.0
HKD2_k127_7622168_0 TIGRFAM Glycerol-3-phosphate dehydrogenase, anaerobic A subunit K00111 - 1.1.5.3 0.000000000000000000000008388 107.0
HKD2_k127_7622168_1 FAD binding domain - - - 0.00009597 53.0
HKD2_k127_7624022_0 domain, Protein - - - 0.0000000000000000153 97.0
HKD2_k127_7624022_1 Hep Hag repeat protein - - - 0.0000000001242 74.0
HKD2_k127_7641765_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 5.673e-210 666.0
HKD2_k127_7641765_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.000006558 49.0
HKD2_k127_7645862_0 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000006758 220.0
HKD2_k127_7645862_1 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000001011 94.0
HKD2_k127_7664596_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.00000000000000009368 86.0
HKD2_k127_7667739_0 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000002576 180.0
HKD2_k127_7667739_1 Protein of unknown function (DUF2961) - - - 0.0000000000000000000000000000000000000000001262 166.0
HKD2_k127_7678490_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 503.0
HKD2_k127_772199_0 HMGL-like K02594,K10977 GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005058 483.0
HKD2_k127_772199_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000432 208.0
HKD2_k127_7725173_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000003719 229.0
HKD2_k127_7725173_1 Protein of unknown function (DUF3795) - - - 0.00000000000000000000000000000000000005544 149.0
HKD2_k127_7730018_0 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000009328 203.0
HKD2_k127_7730018_1 Predicted metal-binding protein (DUF2284) - - - 0.00000000000000000000000000000000000007037 152.0
HKD2_k127_7730018_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000001716 154.0
HKD2_k127_7735160_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007587 486.0
HKD2_k127_7735160_1 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000567 221.0
HKD2_k127_7735160_2 Pkd domain containing protein - - - 0.000002516 58.0
HKD2_k127_7748977_0 Protein of unknown function (DUF454) K09790 - - 0.0000000000000000000002249 101.0
HKD2_k127_7748977_1 Protein of unknown function (DUF1294) - - - 0.000000000000000001491 88.0
HKD2_k127_7748977_2 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 0.000000000000000001775 94.0
HKD2_k127_7750667_0 Hydantoinase/oxoprolinase N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 417.0
HKD2_k127_7756620_0 phenylalanine-tRNA ligase activity K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 441.0
HKD2_k127_7756620_1 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.0000000000000000000000000000000000000000000000001616 179.0
HKD2_k127_7756620_2 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000006252 117.0
HKD2_k127_7757387_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001929 239.0
HKD2_k127_7757387_1 Glutamine amidotransferases class-II - - - 0.00000000000000000000000000000008641 134.0
HKD2_k127_7757387_2 Pathogenicity locus - - - 0.00000000004445 66.0
HKD2_k127_7765008_0 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000003428 123.0
HKD2_k127_7765008_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000002502 65.0
HKD2_k127_7772798_0 Hydrogenase expression formation protein (HypD) K04654 - - 0.00000000000000000000000000000000000000000000000000001632 192.0
HKD2_k127_7772798_1 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000004623 123.0
HKD2_k127_7772798_2 - - - - 0.0000000000000000000008137 101.0
HKD2_k127_7773165_0 cysteine-tRNA ligase activity K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 574.0
HKD2_k127_7773165_1 TIGRFAM Serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000004201 254.0
HKD2_k127_7773165_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000006515 138.0
HKD2_k127_7773165_3 Elongator protein 3 MiaB NifB - - - 0.00000000000000002335 83.0
HKD2_k127_7777104_0 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000000005152 168.0
HKD2_k127_7777104_1 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000153 125.0
HKD2_k127_7785698_0 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000006556 176.0
HKD2_k127_7785698_1 PFAM NHL repeat containing protein - - - 0.0000000000000000004765 98.0
HKD2_k127_7807592_0 ABC-type multidrug transport system ATPase K01990,K16907 - - 0.00000000000000000000000000000000000000000000000000000000000000000007213 241.0
HKD2_k127_7812703_0 AIR synthase related protein, C-terminal domain K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 457.0
HKD2_k127_7812703_1 membrane - - - 0.0000000002115 70.0
HKD2_k127_7823856_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000001278 228.0
HKD2_k127_7823856_1 Predicted membrane protein (DUF2085) - - - 0.00000000000000000000009232 101.0
HKD2_k127_7823856_2 Beta-Casp domain K07041 - - 0.0000003307 54.0
HKD2_k127_7827413_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000000000000000000000000000001924 203.0
HKD2_k127_7827413_1 PFAM iron-containing alcohol dehydrogenase K00005 - 1.1.1.6 0.00000000000000000000000000000000000002527 145.0
HKD2_k127_7827413_2 Fibronectin type III domain - - - 0.00000000000000000000000000000004534 139.0
HKD2_k127_7839552_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 432.0
HKD2_k127_7839552_1 NAD dependent epimerase dehydratase family - - - 0.0000000000000000000000000000000000001197 144.0
HKD2_k127_7839552_2 GlcNAc-PI de-N-acetylase - - - 0.00004395 54.0
HKD2_k127_7840495_0 Radical_SAM C-terminal domain K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 505.0
HKD2_k127_7840495_1 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000001426 207.0
HKD2_k127_7840495_2 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000223 178.0
HKD2_k127_7840495_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000000000000000000000004059 169.0
HKD2_k127_7840495_4 - - - - 0.000001053 54.0
HKD2_k127_7880591_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 438.0
HKD2_k127_7880591_1 NADH ubiquinone oxidoreductase subunit 1 (Chain H) K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 308.0
HKD2_k127_7880591_2 Belongs to the complex I 20 kDa subunit family K00331,K22159 - 1.5.98.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000005107 260.0
HKD2_k127_7880591_3 intracellular protease K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000001406 196.0
HKD2_k127_7880591_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000004018 102.0
HKD2_k127_7880591_5 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000747 47.0
HKD2_k127_7880591_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0002532 48.0
HKD2_k127_7897690_0 MMPL family K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000001585 247.0
HKD2_k127_7958805_0 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000006452 218.0
HKD2_k127_7958805_1 metal ion binding - - - 0.000000000000000000001289 103.0
HKD2_k127_7958805_2 Belongs to the UPF0235 family K09131 - - 0.0000000000002336 74.0
HKD2_k127_7958805_3 protein conserved in archaea K09723 - - 0.000000001795 67.0
HKD2_k127_7961252_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 314.0
HKD2_k127_7961252_1 COG1522 Transcriptional regulators K03718 - - 0.00000000000000000000000000000000000002711 147.0
HKD2_k127_7970917_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000001853 124.0
HKD2_k127_7970917_1 archaeal Zn-finger protein - - - 0.00000000000000000000000000001474 125.0
HKD2_k127_7970917_2 PFAM beta-lactamase domain protein - - - 0.0000000000004363 70.0
HKD2_k127_7980330_0 N-terminal 7TM region of histidine kinase - - - 0.000000000000000000003734 109.0
HKD2_k127_7983422_0 Met-10+ like-protein K07055 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000662 271.0
HKD2_k127_7983422_1 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000004 97.0
HKD2_k127_7983422_2 - - - - 0.00000000015 67.0
HKD2_k127_7988632_0 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 377.0
HKD2_k127_7988632_1 iron ion homeostasis K04758 - - 0.0001283 47.0
HKD2_k127_7989465_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 486.0
HKD2_k127_7990839_0 Glycosyltransferase like family 2 K11936 - - 0.00000000000000000000000000000000000000000000000000000000000000000002467 239.0
HKD2_k127_7990839_1 Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000001822 171.0
HKD2_k127_7990839_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000004556 115.0
HKD2_k127_7998727_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000002109 244.0
HKD2_k127_7998727_1 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000006666 203.0
HKD2_k127_8008866_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001416 273.0
HKD2_k127_8008866_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000005345 162.0
HKD2_k127_8008866_2 Belongs to the thioredoxin family K03671 - - 0.000000000000000512 79.0
HKD2_k127_8010180_0 ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 433.0
HKD2_k127_8010180_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000005684 151.0
HKD2_k127_801454_0 - - - - 0.00000000000000000000002641 103.0
HKD2_k127_8025676_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000003424 199.0
HKD2_k127_8025676_1 Bacterio-opsin activator HTH domain-containing protein K06930 - - 0.000000000000000944 85.0
HKD2_k127_8028701_0 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000002575 111.0
HKD2_k127_8028701_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000002142 87.0
HKD2_k127_8046558_0 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 314.0
HKD2_k127_8046558_1 - - - - 0.0000000001984 67.0
HKD2_k127_8050779_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 324.0
HKD2_k127_8050779_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000001052 154.0
HKD2_k127_8072086_0 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000892 344.0
HKD2_k127_8072086_1 ribosomal protein S3 K02982 GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 317.0
HKD2_k127_8072086_10 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000001318 198.0
HKD2_k127_8072086_11 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000161 196.0
HKD2_k127_8072086_12 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000001692 186.0
HKD2_k127_8072086_13 binds to the 23S rRNA K02885 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000002515 174.0
HKD2_k127_8072086_14 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000003188 169.0
HKD2_k127_8072086_15 Translation initiation factor SUI1 K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000001798 162.0
HKD2_k127_8072086_16 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000007855 161.0
HKD2_k127_8072086_17 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000001017 166.0
HKD2_k127_8072086_18 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000000003122 129.0
HKD2_k127_8072086_19 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000001363 104.0
HKD2_k127_8072086_2 Forms part of the polypeptide exit tunnel K02930 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 296.0
HKD2_k127_8072086_20 Ribosomal L29 protein K02904 - - 0.00000000000000000001477 92.0
HKD2_k127_8072086_21 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000001913 95.0
HKD2_k127_8072086_22 ribosomal protein S14 K02954 - - 0.0000000000000000003013 91.0
HKD2_k127_8072086_3 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 291.0
HKD2_k127_8072086_4 Ribosomal Proteins L2, C-terminal domain K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002038 257.0
HKD2_k127_8072086_5 Ribosomal family S4e K02987 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000001291 237.0
HKD2_k127_8072086_6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000003429 232.0
HKD2_k127_8072086_7 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000003957 211.0
HKD2_k127_8072086_8 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000239 203.0
HKD2_k127_8072086_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000001412 199.0
HKD2_k127_8078991_0 Transporter - - - 0.000000000000000000000000000000000000000000002136 175.0
HKD2_k127_8078991_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000005077 73.0
HKD2_k127_8099623_0 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009446 375.0
HKD2_k127_8099623_1 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000634 122.0
HKD2_k127_8100357_0 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000000000000001347 239.0
HKD2_k127_8100357_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000002321 160.0
HKD2_k127_8100357_2 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000163 135.0
HKD2_k127_8100357_3 Nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.000000000000000000000000000000009968 129.0
HKD2_k127_8120884_0 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002397 269.0
HKD2_k127_8120884_1 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000001793 155.0
HKD2_k127_8202165_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000007842 224.0
HKD2_k127_8202165_1 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000008296 146.0
HKD2_k127_8202165_2 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000001521 97.0
HKD2_k127_8202165_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000006437 54.0
HKD2_k127_821274_0 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000001517 234.0
HKD2_k127_821274_1 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.00000000000000000000000007349 109.0
HKD2_k127_8240715_0 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000006412 166.0
HKD2_k127_8240715_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000001837 64.0
HKD2_k127_8240715_2 COG0668 Small-conductance mechanosensitive channel K03442 - - 0.00000000009879 72.0
HKD2_k127_8255098_0 Structural component of the gap junctions K22037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 298.0
HKD2_k127_8272075_0 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000005234 182.0
HKD2_k127_8272075_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000001622 163.0
HKD2_k127_8274584_0 AhpC/TSA family K03564 - 1.11.1.15 0.000000000000000000000000000000000000000002145 163.0
HKD2_k127_8274584_1 Amidohydrolase K07045 - - 0.000000000000000000000000000005634 130.0
HKD2_k127_828078_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007622 251.0
HKD2_k127_828078_1 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000009032 223.0
HKD2_k127_8291243_0 Mechanosensitive ion channel K03442,K05802,K16052 - - 0.000000000000000000000000000000000000000000000000000000000000005575 236.0
HKD2_k127_8291243_1 Putative TM nitroreductase - - - 0.0000000000000000000000001448 109.0
HKD2_k127_8296206_0 Beta-Casp domain K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 300.0
HKD2_k127_8296206_1 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000007799 134.0
HKD2_k127_8296206_2 - - - - 0.000002726 56.0
HKD2_k127_8305177_0 C-terminal region of MMR_HSR1 domain K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 429.0
HKD2_k127_8305177_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 302.0
HKD2_k127_8305177_2 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000008949 209.0
HKD2_k127_8320163_0 DRTGG domain protein K06873 - - 0.0000000000000000000000000000000000000005671 153.0
HKD2_k127_8320163_1 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000135 143.0
HKD2_k127_8320163_2 Belongs to the N(4) N(6)-methyltransferase family K00590 - 2.1.1.113 0.000000000004274 74.0
HKD2_k127_832460_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 340.0
HKD2_k127_832460_1 DUF based on E. rectale Gene description (DUF3880) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 333.0
HKD2_k127_8350110_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 444.0
HKD2_k127_8350110_1 Calcineurin-like phosphoesterase superfamily domain K01090 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000001363 225.0
HKD2_k127_8353477_0 KEOPS complex Cgi121-like subunit K09119 - - 0.000000007425 61.0
HKD2_k127_8372103_0 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.000000000000000000000000000000000000000000000000000000000000000000006162 240.0
HKD2_k127_8372103_1 FAD linked oxidases, C-terminal domain - - - 0.0000000000000000000000000000000000003057 156.0
HKD2_k127_8411053_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 377.0
HKD2_k127_8411053_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001342 267.0
HKD2_k127_8411053_2 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000241 100.0
HKD2_k127_8419253_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 435.0
HKD2_k127_8419253_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000001359 196.0
HKD2_k127_8419253_2 Trm112p-like protein - - - 0.00000000000002294 75.0
HKD2_k127_8419253_3 dehydrogenases and related proteins - - - 0.00001077 50.0
HKD2_k127_8420410_0 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000004377 237.0
HKD2_k127_8420410_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000002434 228.0
HKD2_k127_8422584_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 436.0
HKD2_k127_8422584_1 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000006758 220.0
HKD2_k127_8422584_2 Bacterio-opsin activator HTH K06930,K06988 - 1.5.1.40 0.000000000000000000000000000002296 128.0
HKD2_k127_8422584_3 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000001033 126.0
HKD2_k127_8428003_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000006924 159.0
HKD2_k127_8428003_1 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000007674 141.0
HKD2_k127_8428003_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000002907 124.0
HKD2_k127_8428003_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000001494 56.0
HKD2_k127_8432272_0 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 341.0
HKD2_k127_8432272_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 326.0
HKD2_k127_8432272_2 - - - - 0.000000000000000000000000000000006981 134.0
HKD2_k127_843678_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 557.0
HKD2_k127_8439044_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 353.0
HKD2_k127_8445297_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006377 270.0
HKD2_k127_8445297_1 RmlD substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000007961 239.0
HKD2_k127_8453060_0 Belongs to the transketolase family K00615 - 2.2.1.1 4.548e-199 623.0
HKD2_k127_8453060_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000005317 70.0
HKD2_k127_8507269_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 327.0
HKD2_k127_8507269_1 synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000003771 217.0
HKD2_k127_8507269_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000002677 191.0
HKD2_k127_8512213_0 Polyprenyl synthetase K02523,K13787 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007645 274.0
HKD2_k127_8512213_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00311,K17830 - 1.3.1.101,1.3.7.11,1.5.5.1 0.0000000000000000000000000000000000001451 147.0
HKD2_k127_8512213_2 NADH ubiquinone oxidoreductase subunit 2 (Chain N) K00343,K22169 - 1.5.98.3,1.6.5.3 0.000000000000000000000000009561 113.0
HKD2_k127_8522631_0 PFAM Pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 561.0
HKD2_k127_8522631_1 COG1132 ABC-type multidrug transport system, ATPase and permease components K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 429.0
HKD2_k127_8522631_2 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 413.0
HKD2_k127_8522631_3 Belongs to the 5'-nucleotidase family - - - 0.00000000000000000000000000000000000000000000000378 178.0
HKD2_k127_8522631_4 VIT family - - - 0.0002275 51.0
HKD2_k127_8523583_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000003302 198.0
HKD2_k127_8545101_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K19312 GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885 2.1.3.15,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 439.0
HKD2_k127_8545101_1 Conserved carboxylase domain K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 381.0
HKD2_k127_8575259_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 531.0
HKD2_k127_8575259_1 4Fe-4S double cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 304.0
HKD2_k127_8575259_2 Putative zinc- or iron-chelating domain - - - 0.0000000000000000000000000006725 114.0
HKD2_k127_8575259_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000002064 109.0
HKD2_k127_8575259_4 snRNP Sm proteins K04796 GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000922 98.0
HKD2_k127_8575259_5 Binds to the 23S rRNA K02922 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000001184 86.0
HKD2_k127_8575501_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000003172 212.0
HKD2_k127_8575501_1 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.0000000000001278 72.0
HKD2_k127_8575501_2 Radical SAM superfamily K04069 - 1.97.1.4 0.0000004941 56.0
HKD2_k127_8589115_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 346.0
HKD2_k127_8589115_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000005254 249.0
HKD2_k127_8589115_2 PFAM GvpD gas vesicle - - - 0.00000000000000000000000000000000000007061 160.0
HKD2_k127_8589115_3 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000003092 66.0
HKD2_k127_8605625_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 370.0
HKD2_k127_8605625_1 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 286.0
HKD2_k127_8605625_2 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000002362 152.0
HKD2_k127_8605625_3 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000001377 138.0
HKD2_k127_8605625_4 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.0000000000000000000004504 96.0
HKD2_k127_8607047_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 408.0
HKD2_k127_8607047_1 Uncharacterised protein family (UPF0179) K09730 - - 0.0000000000000000000000000000001255 126.0
HKD2_k127_8607047_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000001571 117.0
HKD2_k127_860919_0 Acyl-CoA reductase (LuxC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 379.0
HKD2_k127_860919_1 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 334.0
HKD2_k127_860919_2 UbiA prenyltransferase family K02548 - 2.5.1.74 0.000000000000002056 87.0
HKD2_k127_8627071_0 Glycosyltransferase like family 2 K11936 - - 0.0000000000000000000000000000000000000000000000000000000001963 208.0
HKD2_k127_8627071_1 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000043 123.0
HKD2_k127_8628535_0 TIGRFAM arsenite-activated ATPase ArsA K01551 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.16 0.000000000000000000000000000000000000000000000000000002506 203.0
HKD2_k127_8628535_1 - - - - 0.000002345 56.0
HKD2_k127_8642008_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000001949 177.0
HKD2_k127_8642008_1 RNA binding K09736 - - 0.000000000000000000000000000004776 123.0
HKD2_k127_8642008_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0000000000000000000000000006789 122.0
HKD2_k127_8642008_3 CAAX protease self-immunity - - - 0.0000000000000109 79.0
HKD2_k127_8646258_0 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000001713 153.0
HKD2_k127_8646258_1 PFAM glycine cleavage H-protein - - - 0.000000000000000000000000001079 122.0
HKD2_k127_8646258_2 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000002564 83.0
HKD2_k127_8663744_0 Lamin Tail Domain - - - 0.000000000000000000000000000594 127.0
HKD2_k127_8664778_0 Adenosylcobinamide amidohydrolase - - - 0.00000000000000000000000000000000005219 148.0
HKD2_k127_8664778_1 domain, Protein - - - 0.0000001736 60.0
HKD2_k127_8673367_0 peptidyl-prolyl cis-trans isomerase K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000001415 168.0
HKD2_k127_8679195_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 619.0
HKD2_k127_8679195_1 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 352.0
HKD2_k127_8679195_2 Methanogenesis marker protein 5 - - - 0.0000000000000000000000000000000000000000000000000000000001369 209.0
HKD2_k127_8679195_3 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000006081 129.0
HKD2_k127_8679195_4 PFAM NADPH-dependent FMN reductase - - - 0.000000000001869 69.0
HKD2_k127_8679195_5 TIGRFAM methanogenesis marker protein 6 - - - 0.000000001218 61.0
HKD2_k127_8683241_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000009325 106.0
HKD2_k127_8696625_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 426.0
HKD2_k127_8696625_1 DnaB-like helicase C terminal domain - - - 0.000000000000000000000000000000000004354 145.0
HKD2_k127_8696625_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000003083 100.0
HKD2_k127_8704702_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000009795 132.0
HKD2_k127_8704702_1 - K00960 - 2.7.7.6 0.000000000000000007208 85.0
HKD2_k127_871532_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 393.0
HKD2_k127_8723061_0 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000001029 229.0
HKD2_k127_8727317_1 membrane-associated protein domain - - - 0.000007176 55.0
HKD2_k127_8739911_0 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000209 164.0
HKD2_k127_8740592_0 Radical SAM - - - 1.892e-195 625.0
HKD2_k127_8740592_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00311,K17830 - 1.3.1.101,1.3.7.11,1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000002021 246.0
HKD2_k127_8740592_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000003102 226.0
HKD2_k127_8746004_0 Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002018 262.0
HKD2_k127_8746004_1 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000001789 177.0
HKD2_k127_8746004_2 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000000000002759 132.0
HKD2_k127_8763626_0 RNA secondary structure unwinding K03724 - - 0.0000000000000000000000000000000000000004297 163.0
HKD2_k127_8763626_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000001954 143.0
HKD2_k127_8779214_0 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000001435 227.0
HKD2_k127_8779214_1 Signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000001364 150.0
HKD2_k127_8790858_0 DEAD DEAH box helicase domain protein K10896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 469.0
HKD2_k127_8790858_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005183 269.0
HKD2_k127_8790858_2 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000001395 194.0
HKD2_k127_8790858_3 Iron-sulfur cluster assembly accessory protein K13628,K15724 - - 0.0000000000000000000000000000003547 125.0
HKD2_k127_8790858_4 Ferric uptake regulator, Fur family K09825 - - 0.0000000000000000007525 91.0
HKD2_k127_8790858_5 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000005295 81.0
HKD2_k127_8790858_6 Fibronectin type III domain - - - 0.00000001822 63.0
HKD2_k127_8790858_7 Cobalt transport protein component CbiN - - - 0.0000001196 57.0
HKD2_k127_8833824_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 332.0
HKD2_k127_8833824_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000126 262.0
HKD2_k127_8833824_2 - - - - 0.0000000000000004544 88.0
HKD2_k127_8833824_3 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000008904 74.0
HKD2_k127_8836235_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 379.0
HKD2_k127_8836235_1 GXGXG motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 371.0
HKD2_k127_8837014_0 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000906 355.0
HKD2_k127_8837014_1 SIS domain K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000006113 168.0
HKD2_k127_8837014_2 COP9 signalosome complex subunit 5 K09613 GO:0000003,GO:0000338,GO:0000749,GO:0000754,GO:0000909,GO:0003006,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008180,GO:0008233,GO:0008234,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0010893,GO:0016787,GO:0019216,GO:0019218,GO:0019222,GO:0019236,GO:0019538,GO:0019783,GO:0019784,GO:0019953,GO:0022414,GO:0023051,GO:0023058,GO:0030447,GO:0030448,GO:0030582,GO:0030584,GO:0031136,GO:0031137,GO:0031139,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032443,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0036211,GO:0040007,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044703,GO:0045116,GO:0045834,GO:0045940,GO:0046889,GO:0046890,GO:0046999,GO:0048518,GO:0048522,GO:0048583,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050810,GO:0050896,GO:0051704,GO:0051716,GO:0061458,GO:0062012,GO:0062013,GO:0065007,GO:0070011,GO:0070452,GO:0070646,GO:0070647,GO:0070791,GO:0070887,GO:0071310,GO:0071444,GO:0071704,GO:0075259,GO:0080090,GO:0106118,GO:0106120,GO:0140096,GO:1901564,GO:1902930,GO:1902932,GO:2000241,GO:2000243 - 0.00000000000643 74.0
HKD2_k127_8837014_3 ThiF family K21029 - 2.7.7.80 0.000000002736 63.0
HKD2_k127_8837014_4 Belongs to the ubiquitin-conjugating enzyme family K06688 GO:0000209,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006513,GO:0006807,GO:0007088,GO:0007346,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009896,GO:0009987,GO:0010498,GO:0010564,GO:0010638,GO:0010948,GO:0010965,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0019941,GO:0030071,GO:0030163,GO:0031145,GO:0031331,GO:0031625,GO:0032270,GO:0032436,GO:0032446,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044424,GO:0044464,GO:0045732,GO:0045786,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045930,GO:0045931,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051247,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0061630,GO:0061631,GO:0061650,GO:0061659,GO:0062033,GO:0065007,GO:0070647,GO:0071704,GO:0090068,GO:0090231,GO:0090233,GO:0090266,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901976,GO:1901977,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902426,GO:1903052,GO:1903364,GO:1903504,GO:1905818,GO:1905820,GO:2001252 2.3.2.23 0.0000001946 61.0
HKD2_k127_8837014_5 Protein of unknown function (DUF4011) - - - 0.00004577 51.0
HKD2_k127_8871405_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 503.0
HKD2_k127_8871405_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 380.0
HKD2_k127_8871405_2 - - - - 0.000000000000000000000000000000000000000000001616 173.0
HKD2_k127_8871405_3 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.260 0.000000000000000000000003113 111.0
HKD2_k127_8871405_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000002186 100.0
HKD2_k127_8871405_5 membrane - - - 0.00000000000549 73.0
HKD2_k127_8871405_6 membrane - - - 0.00000001478 63.0
HKD2_k127_8879665_0 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001761 278.0
HKD2_k127_8879665_1 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000008628 247.0
HKD2_k127_8879665_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03237 - - 0.000000000000000001232 89.0
HKD2_k127_8879665_3 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000001599 77.0
HKD2_k127_8879665_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000005756 52.0
HKD2_k127_8909270_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 425.0
HKD2_k127_8909270_1 PFAM GvpD gas vesicle - - - 0.0000000000000003431 85.0
HKD2_k127_8930074_0 Hemerythrin HHE cation binding domain - - - 0.00000002231 62.0
HKD2_k127_8930074_1 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.00008529 48.0
HKD2_k127_8946309_0 Belongs to the complex I 20 kDa subunit family K14088 - - 0.00000000000000000000000000000000000000000000000000001317 195.0
HKD2_k127_8946309_1 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14090 - - 0.0000000000000000000000000000000000000002726 154.0
HKD2_k127_8946309_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00004024 51.0
HKD2_k127_8951959_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 369.0
HKD2_k127_8956692_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 591.0
HKD2_k127_8956692_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003057 244.0
HKD2_k127_8956692_2 PFAM amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000005997 181.0
HKD2_k127_8956692_3 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.00000000000000000000000000000000000000189 150.0
HKD2_k127_8956692_4 - - - - 0.000000002068 59.0
HKD2_k127_8956692_5 PFAM Phosphate-starvation-inducible E - - - 0.000000005248 63.0
HKD2_k127_8972441_0 PFAM ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 493.0
HKD2_k127_8972441_1 - - - - 0.00000000000000000000000000000009081 128.0
HKD2_k127_8972441_2 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000464 76.0
HKD2_k127_8981149_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 548.0
HKD2_k127_8981149_1 Cation transporter/ATPase, N-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 353.0
HKD2_k127_8981149_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K18557 - 1.3.1.6,1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000164 162.0
HKD2_k127_8995821_0 domain protein - - - 0.000000000000000000000000000000000000000000000004745 186.0
HKD2_k127_8995821_1 PFAM PQQ enzyme repeat - - - 0.000000000000004109 83.0
HKD2_k127_899683_0 aspartate carbamoyltransferase activity K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 434.0
HKD2_k127_899683_1 Sugar-specific transcriptional regulator TrmB - - - 0.00000000000001608 74.0
HKD2_k127_899683_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000002319 78.0
HKD2_k127_9017160_0 PFAM Type II secretion system protein E K07332 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 454.0
HKD2_k127_9017160_1 type II secretion system protein K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005853 273.0
HKD2_k127_9017160_2 Histidine kinase - - - 0.0000000000000000000000004556 115.0
HKD2_k127_9035792_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 287.0
HKD2_k127_9035792_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000003078 200.0
HKD2_k127_9035792_2 UbiA prenyltransferase family K17105 - 2.5.1.42 0.000000000007863 65.0
HKD2_k127_9035792_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000008738 73.0
HKD2_k127_9045140_0 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.000000000000000000000000000008599 122.0
HKD2_k127_9045140_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531,K12955 - 3.6.3.2 0.0000000005157 63.0
HKD2_k127_9049831_0 Chemotaxis sensory transducer K03406 - - 0.0000000000000000000000000001756 128.0
HKD2_k127_9054629_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000001591 257.0
HKD2_k127_9054629_1 GrpB protein - - - 0.0000000000000001869 85.0
HKD2_k127_9058410_0 pyruvate flavodoxin ferredoxin oxidoreductase K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 365.0
HKD2_k127_9058410_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 302.0
HKD2_k127_9058410_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 297.0
HKD2_k127_9058410_3 pyruvate synthase activity K00172,K00189 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000002054 182.0
HKD2_k127_9058410_4 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 GO:0000470,GO:0000491,GO:0000492,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030515,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034512,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1902555,GO:1905348,GO:1990904 - 0.00000000000000000000000000000000000000000000004962 173.0
HKD2_k127_9058410_5 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000000005055 122.0
HKD2_k127_9058410_6 oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000002514 111.0
HKD2_k127_9058410_7 binds to the 23S rRNA K02896 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.000000000000000000004757 95.0
HKD2_k127_9058410_8 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000001964 82.0
HKD2_k127_905931_0 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000002141 140.0
HKD2_k127_905931_1 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000001646 135.0
HKD2_k127_905931_2 Ammonium Transporter K03320 - - 0.0000003022 54.0
HKD2_k127_9065337_0 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 397.0
HKD2_k127_9065337_1 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000008548 107.0
HKD2_k127_9066300_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002118 284.0
HKD2_k127_9066300_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000005429 244.0
HKD2_k127_9115283_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000001048 145.0
HKD2_k127_9115283_1 Fibronectin type III domain - - - 0.000000000000000000000000000002431 139.0
HKD2_k127_9115283_2 Ribonucleotide reductase, all-alpha domain - - - 0.00000000005285 63.0
HKD2_k127_9115283_3 regulatory protein, arsR - - - 0.000000002886 62.0
HKD2_k127_9146195_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000935 286.0
HKD2_k127_9146195_1 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000003147 113.0
HKD2_k127_9167927_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0000000000000000000000000000000000000000000000000000000000000000009199 237.0
HKD2_k127_9167927_1 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000003959 216.0
HKD2_k127_9167927_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000004076 206.0
HKD2_k127_9171652_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 5.209e-244 773.0
HKD2_k127_9171652_1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 K03049 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000001735 237.0
HKD2_k127_9171652_2 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000004779 129.0
HKD2_k127_9171652_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000001993 94.0
HKD2_k127_9171652_4 Belongs to the UPF0218 family K09735 - - 0.000000000000000002678 91.0
HKD2_k127_9171652_5 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000004533 79.0
HKD2_k127_9171652_6 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00001458 51.0
HKD2_k127_9174211_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 6.3.4.22 0.00000000000000000000003473 100.0
HKD2_k127_9174211_1 Protein of unknown function (DUF3198) - - - 0.00001567 53.0
HKD2_k127_9174211_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0004181 48.0
HKD2_k127_9190524_0 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 305.0
HKD2_k127_9190524_1 PFAM Iron only hydrogenase large subunit, C-terminal domain - - - 0.0002115 47.0
HKD2_k127_9216371_0 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 353.0
HKD2_k127_9216371_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000003241 122.0
HKD2_k127_9216371_2 transglutaminase - - - 0.0000008417 60.0
HKD2_k127_9221560_0 transport system permease K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 384.0
HKD2_k127_9221560_1 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 334.0
HKD2_k127_9221560_2 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000002569 247.0
HKD2_k127_9221560_3 ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - 0.000000387 56.0
HKD2_k127_926137_0 peptidase M42 family protein - - - 0.00000000000000000000000000000001118 133.0
HKD2_k127_926137_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000006426 97.0
HKD2_k127_926137_2 - - - - 0.0000003333 59.0
HKD2_k127_9280797_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 424.0
HKD2_k127_9282654_0 peptidase activity, acting on L-amino acid peptides K09607 - - 0.000000000000000000000000000000000000000000000000000000000001181 223.0
HKD2_k127_9288045_0 domain protein - - - 0.00000000000008658 84.0
HKD2_k127_9297018_0 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA K00584 - 2.1.1.86 0.000000000000000000000000000000001144 136.0
HKD2_k127_9297018_1 ADP binding - - - 0.0001663 49.0
HKD2_k127_9302875_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 503.0
HKD2_k127_9302875_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000002901 242.0
HKD2_k127_9302875_2 Phosphate transport regulator K07220 - - 0.000004706 51.0
HKD2_k127_9326417_0 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000007829 157.0
HKD2_k127_9326417_1 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000219 138.0
HKD2_k127_9326417_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000008651 123.0
HKD2_k127_9327449_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 397.0
HKD2_k127_9327449_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000005561 140.0
HKD2_k127_9344871_0 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 288.0
HKD2_k127_9345639_0 DEAD/H associated K03724 - - 5.968e-271 849.0
HKD2_k127_9348927_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000506 189.0
HKD2_k127_9348927_1 FMN binding - - - 0.00001579 49.0
HKD2_k127_9348927_2 Protein of unknown function (DUF1634) - - - 0.00001885 53.0
HKD2_k127_9388270_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 330.0
HKD2_k127_9388270_1 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000173 279.0
HKD2_k127_9388270_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000003559 203.0
HKD2_k127_9388270_3 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000126 138.0
HKD2_k127_9388270_4 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000254 127.0
HKD2_k127_9388270_5 but it may be involved in stabilization of the trimeric complex - - - 0.0000007014 52.0
HKD2_k127_9393460_0 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 328.0
HKD2_k127_9393460_1 Arsenical pump membrane protein - - - 0.0000000000000000004198 89.0
HKD2_k127_9393460_2 Membrane protein implicated in regulation of membrane protease activity - - - 0.00000000000005541 75.0
HKD2_k127_940427_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 348.0
HKD2_k127_940427_1 Imidazole acetol-phosphate transaminase K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 334.0
HKD2_k127_940427_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 252.0
HKD2_k127_940427_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000002269 248.0
HKD2_k127_940427_4 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000002205 239.0
HKD2_k127_940427_5 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000001928 177.0
HKD2_k127_9412240_0 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000007957 128.0
HKD2_k127_9452016_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 595.0
HKD2_k127_9452016_1 Histidine kinase K07646 - 2.7.13.3 0.0000000006125 60.0
HKD2_k127_9460529_0 exonuclease activity K16899 - 3.6.4.12 0.000000001052 71.0
HKD2_k127_946122_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 516.0
HKD2_k127_946122_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000001862 167.0
HKD2_k127_946122_2 rRNA small subunit methyltransferase G - - - 0.00000000122 63.0
HKD2_k127_9466630_0 Belongs to the UPF0219 family K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 495.0
HKD2_k127_9472267_0 Protein conserved in bacteria - - - 0.000000000004174 72.0
HKD2_k127_9486931_0 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000009155 235.0
HKD2_k127_9486931_1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000101 177.0
HKD2_k127_9486931_2 LysE type translocator - - - 0.0000000000000000000000001239 115.0
HKD2_k127_9486931_3 Drug exporters of the RND superfamily K06994 - - 0.000000000007473 67.0
HKD2_k127_9521595_0 pyruvate phosphate dikinase K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 335.0
HKD2_k127_9521595_1 histidine kinase DNA gyrase B - - - 0.00003745 46.0
HKD2_k127_9529800_0 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000003015 210.0
HKD2_k127_9529800_1 Cytosine deaminase and related metal-dependent hydrolases - - - 0.0000000000000128 76.0
HKD2_k127_9530582_0 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 344.0
HKD2_k127_9530582_1 Membrane protein implicated in regulation of membrane protease activity - - - 0.0000000000000000003818 89.0
HKD2_k127_9546710_0 UvrD REP helicase K03657,K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 631.0
HKD2_k127_9546710_1 COG3857 ATP-dependent nuclease, subunit B K16899 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001271 295.0
HKD2_k127_9553129_0 Amidohydrolase family - - - 0.000000000000000000000000000000008162 134.0
HKD2_k127_9553129_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000002128 104.0
HKD2_k127_9553129_2 PFAM UspA domain protein - - - 0.0000000000000126 79.0
HKD2_k127_9553129_3 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00001745 50.0
HKD2_k127_9553696_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 399.0
HKD2_k127_9556957_0 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008714 291.0
HKD2_k127_9556957_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000008932 177.0
HKD2_k127_9557954_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K09759 - 6.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 290.0
HKD2_k127_9557954_1 electron transfer activity K05337 - - 0.000001619 54.0
HKD2_k127_957758_0 TIGRFAM PEP-CTERM system TPR-repeat lipoprotein - - - 0.000003938 59.0
HKD2_k127_9596234_0 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000000000000001195 220.0
HKD2_k127_9596234_1 Abc transporter K09817 - - 0.0000000000000000000000000000000000000000000000000000000003101 211.0
HKD2_k127_9596234_2 ABC 3 transport family K09816 - - 0.000000000000000000000000000001382 130.0
HKD2_k127_9597731_0 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528,K16951 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000006192 188.0
HKD2_k127_9597731_1 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000005215 94.0
HKD2_k127_9597731_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.000000000000001287 77.0
HKD2_k127_9597731_3 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000001183 61.0
HKD2_k127_9606897_0 FAD binding domain K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000003326 169.0
HKD2_k127_9606897_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000162 166.0
HKD2_k127_9606897_2 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000004597 105.0
HKD2_k127_9608965_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 326.0
HKD2_k127_9609320_0 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 409.0
HKD2_k127_9609320_1 PFAM Methyltransferase K15256 - - 0.00000000000000000000000000000000000000000000000007567 184.0
HKD2_k127_9609320_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000008055 63.0
HKD2_k127_9614625_0 - - - - 0.00000000000000000000000000000000000001686 160.0
HKD2_k127_9629367_0 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002565 252.0
HKD2_k127_9629367_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000006036 257.0
HKD2_k127_9629367_2 Carbon-nitrogen hydrolase K18540 - 3.5.1.100 0.0000000000000001558 85.0
HKD2_k127_9630104_0 ABC-type Fe3 -siderophore transport system, permease component K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000309 271.0
HKD2_k127_9630104_1 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000001386 250.0
HKD2_k127_9630104_2 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000007099 179.0
HKD2_k127_9630104_3 Aminotransferase class I and II K00817,K04720 - 2.6.1.9,4.1.1.81 0.00000005289 55.0
HKD2_k127_9630104_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000001224 61.0
HKD2_k127_9643251_0 SMART Elongator protein 3 MiaB NifB K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005138 360.0
HKD2_k127_9643251_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000002034 229.0
HKD2_k127_9643251_2 PFAM HhH-GPD superfamily base excision DNA repair protein K07457 - - 0.00000000000000000000000000000000000000000001121 176.0
HKD2_k127_9643251_3 Archaeal Peptidase A24 C-terminus Type II K07991 - 3.4.23.52 0.0000000000000000000000003637 115.0
HKD2_k127_9659829_0 Sulfate permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 265.0
HKD2_k127_9677032_0 MMPL family K06994 - - 0.000000000000000000000000000000000000000000002597 172.0
HKD2_k127_9684844_0 SMART phosphoesterase PHP domain protein K04477 - - 0.000000000000000000000000000000000000000000000000000000000000000000009748 239.0
HKD2_k127_9684844_1 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000004433 203.0
HKD2_k127_9684844_2 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000001126 72.0
HKD2_k127_9689338_0 DEAD/H associated K03724 - - 0.0 1045.0
HKD2_k127_9689338_1 reductase K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 469.0
HKD2_k127_9689338_2 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 387.0
HKD2_k127_9689338_3 metal ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000004982 229.0
HKD2_k127_9689338_4 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000003033 223.0
HKD2_k127_9689338_5 - - - - 0.000000000000000007646 88.0
HKD2_k127_9689338_6 Protein of unknown function (DUF531) K09725 - - 0.00000000000000004241 83.0
HKD2_k127_9689338_7 Protein of unknown function (DUF1059) - - - 0.00000000008397 64.0
HKD2_k127_9689338_8 Rubrerythrin - - - 0.00004934 48.0
HKD2_k127_9693480_0 VIT family - - - 0.0000000007245 68.0
HKD2_k127_9707995_0 PFAM PEGA domain - - - 0.000000000000000000000000001792 123.0
HKD2_k127_9716647_0 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000001902 245.0
HKD2_k127_9716647_1 PFAM metal-dependent phosphohydrolase, HD sub domain K01524,K07012 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000002114 147.0
HKD2_k127_972274_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003763 271.0
HKD2_k127_972274_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000001287 247.0
HKD2_k127_9723974_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 409.0
HKD2_k127_9723974_1 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily K00145,K05829 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 382.0
HKD2_k127_9723974_2 argininosuccinate synthase activity K01940 - 6.3.4.5 0.00000000000006029 77.0
HKD2_k127_9724464_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.0000000000000000000000002549 124.0
HKD2_k127_9724464_1 pfam yhs - - - 0.00000000000000000002029 92.0
HKD2_k127_9724464_2 heavy metal translocating P-type ATPase K17686,K19597 - 3.6.3.54 0.000000000000000008648 84.0
HKD2_k127_9730009_0 Putative zinc- or iron-chelating domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 295.0
HKD2_k127_9730009_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01464,K01465,K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.2,3.5.2.3,3.5.2.5 0.0000000000000000000000000000000000000000000000003669 181.0
HKD2_k127_9737857_0 - - - - 0.0000000000000000000000006509 108.0
HKD2_k127_9737857_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000001914 112.0
HKD2_k127_9752278_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.0000000000000000000000000000000000000000000000000002301 187.0
HKD2_k127_9752278_1 Peptidyl-tRNA hydrolase PTH2 K04794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.29 0.000000000000000000000000000000000001202 141.0
HKD2_k127_9769624_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 414.0
HKD2_k127_9805445_0 DEAD/H associated K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 418.0
HKD2_k127_9812795_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000008047 164.0
HKD2_k127_9812795_1 Thiamine-binding protein - - - 0.00000000000000001044 85.0
HKD2_k127_9832231_0 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 1.366e-211 660.0
HKD2_k127_9832231_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000001177 80.0
HKD2_k127_9834590_0 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 6.631e-269 837.0
HKD2_k127_9834590_1 PFAM Methyl-coenzyme M reductase gamma subunit K00402 - 2.8.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 393.0
HKD2_k127_9834590_2 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 299.0
HKD2_k127_9834590_3 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002799 271.0
HKD2_k127_9834590_4 TfuA-like protein - - - 0.00000000000000000000000000000000000000000000001414 178.0
HKD2_k127_9834590_5 - - - - 0.0000000000000000000000000000000000000003926 156.0
HKD2_k127_9834590_6 PFAM Methyl-coenzyme M reductase, protein D K03422 - - 0.0000000000000000000000000000000005689 135.0
HKD2_k127_9834590_7 Carboxymuconolactone decarboxylase family - - - 0.00000000000001422 78.0
HKD2_k127_9834590_8 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.0000000438 57.0
HKD2_k127_9834785_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000003063 59.0
HKD2_k127_9845140_0 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000000001483 148.0
HKD2_k127_9845140_1 Family with sequence similarity 169 member B - - - 0.00007303 52.0
HKD2_k127_9864738_0 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 441.0
HKD2_k127_9899609_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 332.0
HKD2_k127_9899609_1 TatD related DNase K07049 - - 0.000000000000000000000000000000000000000000000000000000000007908 213.0
HKD2_k127_9899609_2 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000002422 88.0
HKD2_k127_9918660_0 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000003064 266.0
HKD2_k127_9918660_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000002625 208.0
HKD2_k127_9918660_2 Double zinc ribbon - - - 0.000006996 57.0
HKD2_k127_9927328_0 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000005743 214.0
HKD2_k127_9927328_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000004963 147.0
HKD2_k127_9927328_2 redox-active disulfide protein 2 - - - 0.0000000000007043 73.0
HKD2_k127_9927328_3 - - - - 0.0000001431 60.0
HKD2_k127_9935560_0 DUF based on E. rectale Gene description (DUF3880) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008915 527.0
HKD2_k127_9935560_1 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000001429 192.0
HKD2_k127_9935560_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000001663 139.0
HKD2_k127_9937063_0 PFAM formate-tetrahydrofolate ligase FTHFS K01938 - 6.3.4.3 2.664e-213 676.0
HKD2_k127_9937063_1 xylanase chitin deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000001008 173.0
HKD2_k127_9937063_2 NAD(P)-binding Rossmann-like domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000004229 148.0
HKD2_k127_9937063_3 Domain of unknown function (DUF3786) - - - 0.0000000000000000000005373 106.0
HKD2_k127_9938407_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 439.0
HKD2_k127_9962498_0 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000005219 160.0
HKD2_k127_9962498_1 Peptidyl-tRNA hydrolase PTH2 K04794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.29 0.000000000000000000000000000000000001648 141.0
HKD2_k127_9973447_0 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000008377 83.0
HKD2_k127_9973447_1 Protein of unknown function (DUF1294) - - - 0.0000000000001493 74.0
HKD2_k127_9994399_0 COG0530 Ca2 Na antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 394.0
HKD2_k127_9994399_1 ThiF family - - - 0.000000000000000001604 92.0