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Overview

ID MAG01836
Name HKD3_bin.14
Sample SMP0048
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus JALHSR01
Species
Assembly information
Completeness (%) 79.31
Contamination (%) 0.88
GC content (%) 41.0
N50 (bp) 11,460
Genome size (bp) 2,092,602

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1804

Gene name Description KEGG GOs EC E-value Score Sequence
HKD3_k127_1193332_0 helicase superfamily c-terminal domain - - - 0.0000000000000000000000000000000004442 132.0
HKD3_k127_1193332_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000004386 99.0
HKD3_k127_1193332_2 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000002405 82.0
HKD3_k127_1193332_3 Protein of unknown function DUF45 K07043 - - 0.00000002971 55.0
HKD3_k127_1203688_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 4.51e-289 897.0
HKD3_k127_1203688_1 Glycogen synthase - - - 6.649e-201 641.0
HKD3_k127_1203688_10 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 300.0
HKD3_k127_1203688_11 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004616 287.0
HKD3_k127_1203688_12 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003433 281.0
HKD3_k127_1203688_13 Circadian clock protein KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006936 248.0
HKD3_k127_1203688_14 methyltransferase activity K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000002471 194.0
HKD3_k127_1203688_15 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000004132 187.0
HKD3_k127_1203688_16 4Fe-4S dicluster domain K00196 - - 0.000000000000000000000000000000000000000000000000218 182.0
HKD3_k127_1203688_17 PFAM GvpD gas vesicle - - - 0.0000000000000000000000000000000000000000000000005672 192.0
HKD3_k127_1203688_18 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000002164 162.0
HKD3_k127_1203688_19 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000007621 152.0
HKD3_k127_1203688_2 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 455.0
HKD3_k127_1203688_20 Pfam:DUF552 K09152 - - 0.000000000000000000005536 96.0
HKD3_k127_1203688_21 Starch synthase catalytic domain - - - 0.0000000000000000002663 91.0
HKD3_k127_1203688_22 Pas domain - - - 0.00001578 52.0
HKD3_k127_1203688_3 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 445.0
HKD3_k127_1203688_4 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 415.0
HKD3_k127_1203688_5 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 404.0
HKD3_k127_1203688_6 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 350.0
HKD3_k127_1203688_7 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 328.0
HKD3_k127_1203688_8 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 330.0
HKD3_k127_1203688_9 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 308.0
HKD3_k127_121074_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 348.0
HKD3_k127_121074_1 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000004107 250.0
HKD3_k127_121074_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000003175 214.0
HKD3_k127_121074_3 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000001947 88.0
HKD3_k127_1255464_0 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 286.0
HKD3_k127_1255464_1 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000001711 237.0
HKD3_k127_1255464_2 PFAM extracellular solute-binding protein family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000007209 231.0
HKD3_k127_1255464_3 Acyl-CoA thioester hydrolase/BAAT N-terminal region K06889 - - 0.000000000000000000000000000000003455 147.0
HKD3_k127_1299803_0 Sulfate transporter K03321 - - 0.000000000000000000000000000000000000000000000003295 183.0
HKD3_k127_1299803_1 - - - - 0.000000000000000000000000000000000000000000001274 173.0
HKD3_k127_1299803_2 Chlorophyllase enzyme - - - 0.000000000000000000000000000000000000000551 160.0
HKD3_k127_1299803_3 PFAM Secreted repeat of - - - 0.0000000000000000001602 90.0
HKD3_k127_1299803_4 membrane - - - 0.00005964 49.0
HKD3_k127_1302608_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.071e-288 905.0
HKD3_k127_1302608_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 500.0
HKD3_k127_1302608_10 - - - - 0.00000000000001169 80.0
HKD3_k127_1302608_2 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 440.0
HKD3_k127_1302608_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006859 434.0
HKD3_k127_1302608_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 362.0
HKD3_k127_1302608_5 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000006717 250.0
HKD3_k127_1302608_6 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000002167 223.0
HKD3_k127_1302608_7 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000005061 190.0
HKD3_k127_1302608_8 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000003843 188.0
HKD3_k127_1302608_9 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000001019 168.0
HKD3_k127_138324_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 365.0
HKD3_k127_138324_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 338.0
HKD3_k127_138324_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 338.0
HKD3_k127_138324_3 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 326.0
HKD3_k127_138324_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002153 279.0
HKD3_k127_138324_5 binds to the 23S rRNA K02921 - - 0.00000000000000000000000000003328 118.0
HKD3_k127_138324_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000002038 90.0
HKD3_k127_138324_7 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000002551 89.0
HKD3_k127_138324_8 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000002042 52.0
HKD3_k127_1391955_0 Winged helix-turn-helix domain (DUF2582) - - - 0.0000003651 58.0
HKD3_k127_1423000_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 574.0
HKD3_k127_1423000_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 535.0
HKD3_k127_1423000_10 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000002416 93.0
HKD3_k127_1423000_11 COG1335 Amidases related to nicotinamidase - - - 0.00000000000000001687 85.0
HKD3_k127_1423000_12 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000001237 81.0
HKD3_k127_1423000_13 PFAM Cache, type 2 domain protein - - - 0.0000002746 53.0
HKD3_k127_1423000_14 transcription initiation from RNA polymerase II promoter - - - 0.000009839 48.0
HKD3_k127_1423000_15 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00007244 48.0
HKD3_k127_1423000_2 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003771 241.0
HKD3_k127_1423000_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000008078 228.0
HKD3_k127_1423000_4 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000181 166.0
HKD3_k127_1423000_5 NUDIX domain K03574 - 3.6.1.55 0.000000000000000000000000000000000000000001688 160.0
HKD3_k127_1423000_6 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000008773 167.0
HKD3_k127_1423000_7 COGs COG3415 Transposase and inactivated derivatives K07499 - - 0.00000000000000000000000000000000000004221 147.0
HKD3_k127_1423000_8 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000002652 113.0
HKD3_k127_1423000_9 PFAM Cache, type 2 domain protein - - - 0.000000000000000000000000662 108.0
HKD3_k127_1439246_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 339.0
HKD3_k127_1439246_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 300.0
HKD3_k127_1439246_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 267.0
HKD3_k127_1439246_3 - - - - 0.0000000000000001869 85.0
HKD3_k127_1439246_4 PFAM PRC-barrel domain - - - 0.0000002924 53.0
HKD3_k127_1443979_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 5.857e-317 984.0
HKD3_k127_1443979_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 5.253e-223 706.0
HKD3_k127_1443979_10 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 346.0
HKD3_k127_1443979_11 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 339.0
HKD3_k127_1443979_12 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 320.0
HKD3_k127_1443979_13 PFAM peptidase M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 317.0
HKD3_k127_1443979_14 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 314.0
HKD3_k127_1443979_15 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 306.0
HKD3_k127_1443979_16 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 308.0
HKD3_k127_1443979_17 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 303.0
HKD3_k127_1443979_18 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 298.0
HKD3_k127_1443979_19 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 292.0
HKD3_k127_1443979_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 568.0
HKD3_k127_1443979_20 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 293.0
HKD3_k127_1443979_21 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 283.0
HKD3_k127_1443979_22 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008546 285.0
HKD3_k127_1443979_23 phosphoesterase RecJ domain protein K15986 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006126 284.0
HKD3_k127_1443979_24 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001268 274.0
HKD3_k127_1443979_25 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005471 272.0
HKD3_k127_1443979_26 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000001204 251.0
HKD3_k127_1443979_27 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004814 249.0
HKD3_k127_1443979_28 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000002874 240.0
HKD3_k127_1443979_29 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000003884 213.0
HKD3_k127_1443979_3 malic enzyme K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 500.0
HKD3_k127_1443979_30 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
HKD3_k127_1443979_31 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000506 183.0
HKD3_k127_1443979_32 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000005449 175.0
HKD3_k127_1443979_33 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000008591 175.0
HKD3_k127_1443979_34 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000006869 162.0
HKD3_k127_1443979_35 ABC transporter K09817 - - 0.0000000000000000000000000000000000001793 145.0
HKD3_k127_1443979_36 ABC transporter K09817 - - 0.000000000000000000000000000001331 125.0
HKD3_k127_1443979_37 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000006848 133.0
HKD3_k127_1443979_38 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000007609 113.0
HKD3_k127_1443979_39 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000002036 100.0
HKD3_k127_1443979_4 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 462.0
HKD3_k127_1443979_40 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000001697 82.0
HKD3_k127_1443979_41 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.000000000000000034 82.0
HKD3_k127_1443979_42 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000001782 83.0
HKD3_k127_1443979_43 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000001942 83.0
HKD3_k127_1443979_44 Transposase domain (DUF772) K07481 - - 0.000000000000248 75.0
HKD3_k127_1443979_45 - - - - 0.000000001872 62.0
HKD3_k127_1443979_46 extracellular matrix structural constituent - - - 0.000000004109 68.0
HKD3_k127_1443979_47 phytol kinase activity K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.000000004585 66.0
HKD3_k127_1443979_48 - - - - 0.000000007248 62.0
HKD3_k127_1443979_49 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000001029 52.0
HKD3_k127_1443979_5 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 459.0
HKD3_k127_1443979_50 Transposase domain (DUF772) K07481 - - 0.000003781 49.0
HKD3_k127_1443979_51 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.0001222 46.0
HKD3_k127_1443979_52 Transposase domain (DUF772) K07481 - - 0.0002152 45.0
HKD3_k127_1443979_6 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 428.0
HKD3_k127_1443979_7 PFAM Radical SAM domain protein K02585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 406.0
HKD3_k127_1443979_8 cellular potassium ion transport K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 376.0
HKD3_k127_1443979_9 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 353.0
HKD3_k127_1453314_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.588e-222 703.0
HKD3_k127_1453314_1 PFAM Radical SAM domain protein K06937 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 552.0
HKD3_k127_1453314_10 Belongs to the UPF0434 family - - - 0.00000000000000000000001334 100.0
HKD3_k127_1453314_11 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000004288 96.0
HKD3_k127_1453314_12 ChaB K06197 - - 0.00000000000007407 75.0
HKD3_k127_1453314_13 Transposase and inactivated derivatives - - - 0.0000000000204 67.0
HKD3_k127_1453314_14 Transposase and inactivated derivatives K07494 - - 0.000000003855 59.0
HKD3_k127_1453314_15 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000001691 52.0
HKD3_k127_1453314_16 Histidine kinase K14978 - - 0.00003329 51.0
HKD3_k127_1453314_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 550.0
HKD3_k127_1453314_3 DNA polymerase K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 543.0
HKD3_k127_1453314_4 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 524.0
HKD3_k127_1453314_5 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000000000000000000000000000000001262 179.0
HKD3_k127_1453314_6 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000002635 187.0
HKD3_k127_1453314_7 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000001211 150.0
HKD3_k127_1453314_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000005784 113.0
HKD3_k127_1453314_9 RNA binding K07581 - - 0.000000000000000000000009693 107.0
HKD3_k127_1459297_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 2.264e-309 962.0
HKD3_k127_1459297_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 4.303e-194 619.0
HKD3_k127_1459297_10 - - - - 0.0000000000000000002048 93.0
HKD3_k127_1459297_11 PspC domain K03973 - - 0.000000000000000000255 90.0
HKD3_k127_1459297_12 Alkyl sulfatase dimerisation - - - 0.0000000000002529 74.0
HKD3_k127_1459297_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000269 69.0
HKD3_k127_1459297_14 - - - - 0.00000007335 54.0
HKD3_k127_1459297_15 methyltransferase - - - 0.0000002875 54.0
HKD3_k127_1459297_16 - - - - 0.000003332 56.0
HKD3_k127_1459297_17 Chagasin family peptidase inhibitor I42 K14475 - - 0.000006097 56.0
HKD3_k127_1459297_18 Alkyl sulfatase dimerisation - - - 0.0005102 43.0
HKD3_k127_1459297_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009946 480.0
HKD3_k127_1459297_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 442.0
HKD3_k127_1459297_4 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 332.0
HKD3_k127_1459297_5 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001404 240.0
HKD3_k127_1459297_6 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000002514 205.0
HKD3_k127_1459297_7 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000004619 132.0
HKD3_k127_1459297_8 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000004536 123.0
HKD3_k127_1459297_9 Ferredoxin K05337 - - 0.0000000000000000000005847 97.0
HKD3_k127_1462033_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.489e-265 831.0
HKD3_k127_1462033_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.572e-238 747.0
HKD3_k127_1462033_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 486.0
HKD3_k127_1462033_3 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 450.0
HKD3_k127_1462033_4 Putative small multi-drug export protein - - - 0.000000000000000000000000000000000000000000000000001502 188.0
HKD3_k127_1462033_5 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000001048 144.0
HKD3_k127_1462033_6 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000007453 89.0
HKD3_k127_1462033_7 protein involved in the oxidation of intracellular sulfur K07236 - - 0.00000000000000000169 88.0
HKD3_k127_1462033_8 transposase activity - - - 0.0000003761 55.0
HKD3_k127_1462033_9 transposase activity - - - 0.000007199 51.0
HKD3_k127_1471183_0 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009252 326.0
HKD3_k127_1471183_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 334.0
HKD3_k127_1471183_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000002762 250.0
HKD3_k127_1471183_3 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000002561 235.0
HKD3_k127_1471183_4 STAS domain K04749 - - 0.000000000000000000005388 96.0
HKD3_k127_1471183_5 COG0517 FOG CBS domain - - - 0.000000000000001815 81.0
HKD3_k127_1471183_6 STAS domain K04749 - - 0.0002839 44.0
HKD3_k127_1479750_0 Formate dehydrogenase alpha subunit K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 6.313e-246 776.0
HKD3_k127_1479750_1 Oxidoreductase NAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000338 240.0
HKD3_k127_1479750_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K16950 - - 0.0000000000000000000000000000000000000000000000000000007728 205.0
HKD3_k127_1480067_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 558.0
HKD3_k127_1480067_1 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000006281 222.0
HKD3_k127_1480067_2 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000002425 206.0
HKD3_k127_1480067_3 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000005077 144.0
HKD3_k127_1480067_4 Chagasin family peptidase inhibitor I42 K14475 - - 0.00000002461 63.0
HKD3_k127_1480067_6 VIT family - - - 0.000000439 60.0
HKD3_k127_1480067_7 - - - - 0.0005913 44.0
HKD3_k127_1483124_0 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000002378 147.0
HKD3_k127_1483124_1 - - - - 0.00000000000000000000000000000000003617 140.0
HKD3_k127_1483124_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000003064 92.0
HKD3_k127_1483124_3 - - - - 0.00000004946 55.0
HKD3_k127_1483124_4 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000008926 51.0
HKD3_k127_1501279_0 low-complexity proteins - - - 0.000000000000000000000000000084 133.0
HKD3_k127_1501279_1 - - - - 0.0000000000000000001099 94.0
HKD3_k127_1501279_2 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000001691 59.0
HKD3_k127_1575247_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000008534 232.0
HKD3_k127_1575247_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000004472 203.0
HKD3_k127_1575247_2 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000004138 102.0
HKD3_k127_1588706_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 299.0
HKD3_k127_1588706_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 290.0
HKD3_k127_1588706_2 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000005648 145.0
HKD3_k127_1588706_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000003274 105.0
HKD3_k127_1588706_4 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000506 86.0
HKD3_k127_1613332_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.682e-274 861.0
HKD3_k127_1613332_1 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005124 253.0
HKD3_k127_1613332_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000007498 214.0
HKD3_k127_1613332_3 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000001163 77.0
HKD3_k127_1628200_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 509.0
HKD3_k127_1628200_1 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006392 365.0
HKD3_k127_1628200_2 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 340.0
HKD3_k127_1628200_3 secreted Zn-dependent protease - - - 0.000000000168 70.0
HKD3_k127_1632382_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 1.827e-207 665.0
HKD3_k127_1632382_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 393.0
HKD3_k127_1632382_10 pyrroloquinoline quinone binding - - - 0.0003405 46.0
HKD3_k127_1632382_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 357.0
HKD3_k127_1632382_3 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 289.0
HKD3_k127_1632382_4 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000000000000000000000000000000000000000000131 225.0
HKD3_k127_1632382_5 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000138 205.0
HKD3_k127_1632382_6 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.00000000000000000000000000000000000000001179 155.0
HKD3_k127_1632382_7 - - - - 0.000000004404 60.0
HKD3_k127_1632382_8 PFAM Protein kinase domain - - - 0.00000005927 61.0
HKD3_k127_1632382_9 YEATS family - - - 0.0001275 51.0
HKD3_k127_163400_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.013e-261 821.0
HKD3_k127_163400_1 TPR Domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 397.0
HKD3_k127_163400_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 303.0
HKD3_k127_163400_3 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000004026 212.0
HKD3_k127_163400_4 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000004868 126.0
HKD3_k127_163400_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.000000000000000000000000000115 118.0
HKD3_k127_163400_6 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000003493 92.0
HKD3_k127_163400_7 - - - - 0.00000000000001854 81.0
HKD3_k127_1658143_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 5.672e-268 842.0
HKD3_k127_1658143_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 4.238e-196 621.0
HKD3_k127_1658143_10 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000185 265.0
HKD3_k127_1658143_11 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009579 242.0
HKD3_k127_1658143_12 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000124 226.0
HKD3_k127_1658143_13 ATP-grasp domain K06914 - 6.3.4.24 0.00000000000000000000000000000000000000000000000000000000000000001556 235.0
HKD3_k127_1658143_14 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000003636 226.0
HKD3_k127_1658143_15 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000003787 187.0
HKD3_k127_1658143_16 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000003158 179.0
HKD3_k127_1658143_17 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001165 175.0
HKD3_k127_1658143_18 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000005194 166.0
HKD3_k127_1658143_19 - - - - 0.0000000000000000000000000000000000000001604 156.0
HKD3_k127_1658143_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 588.0
HKD3_k127_1658143_20 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000002217 127.0
HKD3_k127_1658143_21 Stage II sporulation protein M K06384 - - 0.00000000000000000000000000001201 125.0
HKD3_k127_1658143_22 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000002912 115.0
HKD3_k127_1658143_23 PFAM Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000164 118.0
HKD3_k127_1658143_24 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000002602 111.0
HKD3_k127_1658143_25 SPTR Transposase, IS4 family protein - - - 0.0000000001835 64.0
HKD3_k127_1658143_26 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000002757 72.0
HKD3_k127_1658143_27 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000006103 57.0
HKD3_k127_1658143_3 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 488.0
HKD3_k127_1658143_4 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 490.0
HKD3_k127_1658143_5 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 421.0
HKD3_k127_1658143_6 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 357.0
HKD3_k127_1658143_7 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 327.0
HKD3_k127_1658143_8 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000001282 271.0
HKD3_k127_1658143_9 S-layer protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004407 287.0
HKD3_k127_1699001_0 Alkyl sulfatase dimerisation - - - 7.845e-300 932.0
HKD3_k127_1699001_1 COG2041 Sulfite oxidase and related enzymes - - - 0.0000000000000000000000000000002158 126.0
HKD3_k127_1756161_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 4.326e-219 696.0
HKD3_k127_1756161_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 432.0
HKD3_k127_1756161_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 431.0
HKD3_k127_1756161_3 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001985 254.0
HKD3_k127_1756161_4 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000124 245.0
HKD3_k127_1756161_5 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000428 128.0
HKD3_k127_1756161_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000003644 89.0
HKD3_k127_1756161_7 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.000000000000000003056 86.0
HKD3_k127_1756161_8 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.0000000000000003206 80.0
HKD3_k127_1765693_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 344.0
HKD3_k127_1765693_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009174 339.0
HKD3_k127_1765693_10 PINc domain ribonuclease K09006 - - 0.00000000000003301 74.0
HKD3_k127_1765693_11 Belongs to the Fur family K09825 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001425 70.0
HKD3_k127_1765693_12 Belongs to the Fur family K09825 - - 0.000000007942 59.0
HKD3_k127_1765693_13 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.00002798 48.0
HKD3_k127_1765693_14 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.0001315 44.0
HKD3_k127_1765693_2 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 324.0
HKD3_k127_1765693_3 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 302.0
HKD3_k127_1765693_4 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007905 264.0
HKD3_k127_1765693_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000002046 154.0
HKD3_k127_1765693_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000003148 147.0
HKD3_k127_1765693_7 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.0000000000000000000000000003305 115.0
HKD3_k127_1765693_8 - - - - 0.000000000000000000000004691 104.0
HKD3_k127_1765693_9 PFAM ribonuclease II K01147 - 3.1.13.1 0.00000000000000000006541 92.0
HKD3_k127_1800603_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 503.0
HKD3_k127_1800603_1 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000002965 263.0
HKD3_k127_1800603_2 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.0000000000000000000000000000000000000000000000000001708 199.0
HKD3_k127_1800603_3 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000001865 183.0
HKD3_k127_1800603_4 Uncharacterized protein domain (DUF2202) - - - 0.00000000000000000000000000000000000000007405 165.0
HKD3_k127_1800603_5 COG2041 Sulfite oxidase and related enzymes - - - 0.000000001159 59.0
HKD3_k127_1805013_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.674e-217 689.0
HKD3_k127_1805013_1 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 540.0
HKD3_k127_1805013_2 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000005552 222.0
HKD3_k127_1805013_3 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000004184 106.0
HKD3_k127_1805013_4 Transposase domain (DUF772) K07481 - - 0.0000000000001318 72.0
HKD3_k127_1805013_5 Transposase domain (DUF772) K07481 - - 0.00000000002726 66.0
HKD3_k127_1813255_0 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 289.0
HKD3_k127_187430_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 378.0
HKD3_k127_187430_1 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.90 0.00000000000000000000000000000000000000000000000000003132 198.0
HKD3_k127_187430_2 PFAM Cache, type 2 domain protein - - - 0.000000000000000000000000000000001635 133.0
HKD3_k127_1895594_0 peptidase K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 462.0
HKD3_k127_1895594_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000004738 160.0
HKD3_k127_1895594_2 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000000000000000000001327 106.0
HKD3_k127_1938029_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000008121 250.0
HKD3_k127_1949920_0 PFAM Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 610.0
HKD3_k127_1949920_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 347.0
HKD3_k127_1949920_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002108 269.0
HKD3_k127_1949920_3 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003078 251.0
HKD3_k127_1949920_4 - - - - 0.000000000000000000000000000004059 122.0
HKD3_k127_1949920_5 TOBE domain - - - 0.00000000000000000002071 92.0
HKD3_k127_1949920_6 von Willebrand factor, type A K07114 - - 0.0000005641 61.0
HKD3_k127_199851_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 7.116e-216 683.0
HKD3_k127_199851_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 579.0
HKD3_k127_199851_2 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 578.0
HKD3_k127_199851_3 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 539.0
HKD3_k127_199851_4 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 505.0
HKD3_k127_199851_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000002809 221.0
HKD3_k127_199851_6 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000004056 222.0
HKD3_k127_199851_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000003065 100.0
HKD3_k127_199851_8 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.000000000000000000000702 99.0
HKD3_k127_2057165_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.204e-267 837.0
HKD3_k127_2130985_0 protein with SCP PR1 domains - - - 0.000000000000000000000000000000009235 135.0
HKD3_k127_220346_0 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000005734 181.0
HKD3_k127_220346_1 ester cyclase - - - 0.00000000000000000000672 94.0
HKD3_k127_220346_2 Short C-terminal domain - - - 0.000000000000001047 80.0
HKD3_k127_220346_3 - - - - 0.00000000000009157 77.0
HKD3_k127_220346_4 DNA polymerase activity K02319 - 2.7.7.7 0.00000000188 63.0
HKD3_k127_228629_0 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002343 264.0
HKD3_k127_228629_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008707 263.0
HKD3_k127_2369620_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 332.0
HKD3_k127_2369620_1 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000004647 257.0
HKD3_k127_2369620_2 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000001114 128.0
HKD3_k127_2369620_3 Lamin Tail Domain - - - 0.0000000000000001236 86.0
HKD3_k127_2369620_4 Protein of unknown function (DUF4064) - - - 0.0001398 49.0
HKD3_k127_2378449_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 332.0
HKD3_k127_2378449_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 320.0
HKD3_k127_2378449_2 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000001075 241.0
HKD3_k127_2378449_3 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000001953 83.0
HKD3_k127_2378449_4 radical SAM domain protein - - - 0.00000000001104 68.0
HKD3_k127_2378449_5 Polysaccharide deacetylase - - - 0.0005381 54.0
HKD3_k127_2443078_0 PFAM amino acid permease-associated region K20265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 378.0
HKD3_k127_2443078_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000007304 191.0
HKD3_k127_2443154_0 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 1.692e-289 910.0
HKD3_k127_2443154_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 4.259e-228 723.0
HKD3_k127_2443154_2 Belongs to the carbohydrate kinase PfkB family. LacC subfamily K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007608 343.0
HKD3_k127_2443154_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001018 286.0
HKD3_k127_2443154_4 COG3547 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000211 291.0
HKD3_k127_2443154_5 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000282 215.0
HKD3_k127_2443154_6 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000159 133.0
HKD3_k127_2443154_7 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.00000000001268 65.0
HKD3_k127_2461385_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 2.623e-273 866.0
HKD3_k127_2461385_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 452.0
HKD3_k127_2461385_2 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 366.0
HKD3_k127_2461385_3 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 366.0
HKD3_k127_2461385_4 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 302.0
HKD3_k127_2461385_5 PFAM ribonuclease H K03469 - 3.1.26.4 0.0000000000000000000000004554 109.0
HKD3_k127_2461385_6 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000004157 95.0
HKD3_k127_2461385_7 membrane - - - 0.000007002 59.0
HKD3_k127_2461385_8 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00001405 48.0
HKD3_k127_2485011_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1075.0
HKD3_k127_2485011_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 3.798e-222 694.0
HKD3_k127_2485011_10 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000007928 117.0
HKD3_k127_2485011_11 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000000005583 115.0
HKD3_k127_2485011_2 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 9.058e-199 629.0
HKD3_k127_2485011_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 612.0
HKD3_k127_2485011_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 558.0
HKD3_k127_2485011_5 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 527.0
HKD3_k127_2485011_6 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 432.0
HKD3_k127_2485011_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000007294 181.0
HKD3_k127_2485011_8 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000001768 183.0
HKD3_k127_2485011_9 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000003077 171.0
HKD3_k127_2485079_0 - - - - 2.244e-239 748.0
HKD3_k127_2485079_1 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 369.0
HKD3_k127_2485079_2 PFAM Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 359.0
HKD3_k127_2485079_3 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 287.0
HKD3_k127_2485079_4 Nadph-dependent fmn reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006473 287.0
HKD3_k127_2485079_5 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000005256 241.0
HKD3_k127_2485079_6 PFAM helix-turn-helix HxlR type - - - 0.0000000000000000000000000000000000000000000000000000000000000003389 221.0
HKD3_k127_2485079_7 - - - - 0.000000000000000000000000000000000000183 146.0
HKD3_k127_2485079_8 NADPH-dependent FMN reductase - - - 0.000000000002927 68.0
HKD3_k127_250489_0 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000002676 223.0
HKD3_k127_250489_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000003469 180.0
HKD3_k127_250489_2 PFAM ABC transporter related K01990 - - 0.0000000000000000001524 87.0
HKD3_k127_2560451_0 COG0500 SAM-dependent methyltransferases K17462 - - 0.000000000000000000000000000000000000000000000000000000009402 206.0
HKD3_k127_2560451_1 Bacterial-like globin K06886 - - 0.000000000000000000000000000000002053 132.0
HKD3_k127_2560451_2 Protein of unknown function (DUF2769) - - - 0.00000000000000000003524 96.0
HKD3_k127_2560451_3 UPF0060 membrane protein K09771 - - 0.00000000000001192 74.0
HKD3_k127_2560451_4 Winged helix-turn helix - - - 0.0000568 48.0
HKD3_k127_2560451_5 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000158 45.0
HKD3_k127_2574700_0 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001867 262.0
HKD3_k127_2574700_1 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003461 261.0
HKD3_k127_2574700_2 - - - - 0.00000000000000000000000000000000000000000000000001076 183.0
HKD3_k127_2574700_3 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000003628 166.0
HKD3_k127_2574700_4 TPR Domain containing protein - - - 0.000000000000000000000000000000000000000002606 164.0
HKD3_k127_2574700_5 Transcriptional regulator, TrmB - - - 0.00000000000000000000000001214 114.0
HKD3_k127_2574700_6 Protein of unknown function (DUF2551) - - - 0.00000000000000000003841 94.0
HKD3_k127_2645350_0 Voltage gated chloride channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 461.0
HKD3_k127_2645350_1 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002309 289.0
HKD3_k127_2713492_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005926 478.0
HKD3_k127_2719984_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004104 263.0
HKD3_k127_2719984_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000001407 237.0
HKD3_k127_2719984_2 Peptidase C39 family K06992 - - 0.000000000000000000000000000000000004245 151.0
HKD3_k127_2719984_3 - - - - 0.00000000000000000001123 94.0
HKD3_k127_2723156_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 289.0
HKD3_k127_2723156_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000001098 163.0
HKD3_k127_2723156_2 PFAM Secreted repeat of - - - 0.0000000000000000000000000000001067 128.0
HKD3_k127_2723156_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000004614 84.0
HKD3_k127_2723156_4 4Fe-4S binding domain - - - 0.0001416 44.0
HKD3_k127_2739825_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 499.0
HKD3_k127_2739825_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 441.0
HKD3_k127_2739825_10 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000006589 151.0
HKD3_k127_2739825_11 PAS domain - - - 0.0000000000000002883 92.0
HKD3_k127_2739825_12 PFAM nuclease (SNase domain protein) - - - 0.000002324 57.0
HKD3_k127_2739825_2 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 319.0
HKD3_k127_2739825_3 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002829 274.0
HKD3_k127_2739825_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003922 273.0
HKD3_k127_2739825_5 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000007291 226.0
HKD3_k127_2739825_6 pfam ammecr1 K09141 - - 0.00000000000000000000000000000000000000000000000000007192 193.0
HKD3_k127_2739825_7 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000000000001904 175.0
HKD3_k127_2739825_8 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000003233 177.0
HKD3_k127_2739825_9 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000002934 172.0
HKD3_k127_2864990_0 AAA family ATPase, CDC48 subfamily K13525 - - 2.473e-296 925.0
HKD3_k127_2864990_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 560.0
HKD3_k127_2864990_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006361 368.0
HKD3_k127_2864990_3 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 328.0
HKD3_k127_2864990_4 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000002969 133.0
HKD3_k127_2864990_5 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000002331 118.0
HKD3_k127_2864990_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - - 0.000000000000000703 83.0
HKD3_k127_2883964_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 418.0
HKD3_k127_2883964_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000002248 184.0
HKD3_k127_2883964_2 Transcriptional regulator, TrmB - - - 0.000000000000000000000000005049 115.0
HKD3_k127_2935498_0 - - - - 0.00000000000000000000000000000000000000000000000000802 185.0
HKD3_k127_297934_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1009.0
HKD3_k127_297934_1 Cys/Met metabolism PLP-dependent enzyme K01758,K01761 - 4.4.1.1,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 475.0
HKD3_k127_297934_10 Belongs to the 'phage' integrase family - - - 0.00002748 51.0
HKD3_k127_297934_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000002401 238.0
HKD3_k127_297934_3 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000006485 205.0
HKD3_k127_297934_4 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000001632 205.0
HKD3_k127_297934_5 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000000001659 123.0
HKD3_k127_297934_6 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000001115 118.0
HKD3_k127_297934_7 Dodecin K09165 - - 0.00000000000000000001535 94.0
HKD3_k127_297934_8 PFAM Glutamine cyclotransferase - - - 0.0000000000000000001964 89.0
HKD3_k127_297934_9 Putative zinc- or iron-chelating domain K06940 - - 0.00000000009101 70.0
HKD3_k127_3015357_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 323.0
HKD3_k127_3015357_1 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005013 261.0
HKD3_k127_3015357_2 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000007533 142.0
HKD3_k127_3037833_0 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000003259 208.0
HKD3_k127_3037833_1 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000871 199.0
HKD3_k127_3037833_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000001078 188.0
HKD3_k127_3037833_3 Amino acid permease K03294 - - 0.0000000000000000000000002814 107.0
HKD3_k127_3037833_4 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000006352 76.0
HKD3_k127_3037833_5 RibD C-terminal domain K14654 - 1.1.1.302 0.0001475 44.0
HKD3_k127_3077081_0 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 291.0
HKD3_k127_3077081_1 PFAM Cache, type 2 domain protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000009811 245.0
HKD3_k127_3077081_2 alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000000000000000004467 113.0
HKD3_k127_3077081_3 ARD/ARD' family K01607 - 4.1.1.44 0.00000000000000003157 85.0
HKD3_k127_3077081_4 TIGRFAM lycopene cyclase domain K22502 - 5.5.1.19 0.0000000000001761 74.0
HKD3_k127_3077081_5 Nitroreductase - - - 0.0000000004778 65.0
HKD3_k127_3077081_6 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.0000001406 57.0
HKD3_k127_3077081_7 Belongs to the 'phage' integrase family K03733,K04763 - - 0.0000001406 57.0
HKD3_k127_3077081_8 Membrane K22502 - 5.5.1.19 0.0002151 49.0
HKD3_k127_3115337_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 8.523e-320 1003.0
HKD3_k127_3115337_1 Aminotransferase class-III K00823,K00836 - 2.6.1.19,2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 520.0
HKD3_k127_3115337_2 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 298.0
HKD3_k127_3115337_3 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001392 276.0
HKD3_k127_3115337_4 - - - - 0.000000000000000002529 89.0
HKD3_k127_3115337_5 PFAM TPR repeat-containing protein - - - 0.00005286 53.0
HKD3_k127_3135048_0 DEAD DEAH box helicase domain protein K10896 - - 5.477e-228 728.0
HKD3_k127_3135048_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.675e-204 659.0
HKD3_k127_3135048_2 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001083 269.0
HKD3_k127_3135048_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000057 237.0
HKD3_k127_3135048_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000007028 165.0
HKD3_k127_3135048_5 Helix-turn-helix domain - - - 0.0000000000000000000000000000001093 128.0
HKD3_k127_3135048_6 Transposase domain (DUF772) K07481 - - 0.00000000002462 67.0
HKD3_k127_3135048_7 Transposase domain (DUF772) K07481 - - 0.0000004634 57.0
HKD3_k127_315682_0 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 340.0
HKD3_k127_315682_1 - - - - 0.0000000000000000000000000000000000000000000004138 174.0
HKD3_k127_315682_2 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.000000000000000001343 92.0
HKD3_k127_315682_3 PFAM CBS domain containing protein - - - 0.0000000000006306 71.0
HKD3_k127_315682_4 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00006612 46.0
HKD3_k127_3159309_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 590.0
HKD3_k127_3159309_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 498.0
HKD3_k127_3159309_10 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000194 248.0
HKD3_k127_3159309_11 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003043 246.0
HKD3_k127_3159309_12 integrase family K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000479 245.0
HKD3_k127_3159309_13 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000001472 241.0
HKD3_k127_3159309_14 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000003491 217.0
HKD3_k127_3159309_15 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000005605 186.0
HKD3_k127_3159309_16 TfuA-like protein - - - 0.0000000000000000000000000000000000000000009351 164.0
HKD3_k127_3159309_17 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000001097 144.0
HKD3_k127_3159309_18 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000001044 142.0
HKD3_k127_3159309_19 PFAM Nucleoside 2-deoxyribosyltransferase - - - 0.000000000000000000000000003043 115.0
HKD3_k127_3159309_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 490.0
HKD3_k127_3159309_20 transposase activity - - - 0.000000000000000000000004919 118.0
HKD3_k127_3159309_21 - - - - 0.0000000000001388 76.0
HKD3_k127_3159309_22 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.0000000001254 65.0
HKD3_k127_3159309_3 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009728 460.0
HKD3_k127_3159309_4 AIR synthase related protein domain protein K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 444.0
HKD3_k127_3159309_5 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 318.0
HKD3_k127_3159309_6 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 285.0
HKD3_k127_3159309_7 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000662 281.0
HKD3_k127_3159309_8 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
HKD3_k127_3159309_9 TIGRFAM archaeoflavoprotein AfpA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009054 246.0
HKD3_k127_3328519_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 553.0
HKD3_k127_3328519_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 473.0
HKD3_k127_3328519_10 - - - - 0.000000000000006076 80.0
HKD3_k127_3328519_11 transposition, DNA-mediated - - - 0.00000001682 57.0
HKD3_k127_3328519_12 transposition, DNA-mediated - - - 0.0000001271 55.0
HKD3_k127_3328519_13 Appr-1'-p processing enzyme - - - 0.0000003622 52.0
HKD3_k127_3328519_14 - - - - 0.0002033 49.0
HKD3_k127_3328519_15 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0004888 47.0
HKD3_k127_3328519_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 421.0
HKD3_k127_3328519_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 338.0
HKD3_k127_3328519_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000003538 174.0
HKD3_k127_3328519_5 PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000000005477 168.0
HKD3_k127_3328519_6 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000006409 161.0
HKD3_k127_3328519_7 uncharacterised conserved protein UCP017998 - - - 0.000000000000000000000003305 113.0
HKD3_k127_3328519_8 - - - - 0.00000000000000000000004493 102.0
HKD3_k127_3328519_9 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000000217 89.0
HKD3_k127_3444846_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 604.0
HKD3_k127_3444846_1 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 387.0
HKD3_k127_3444846_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000007352 56.0
HKD3_k127_3472351_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 557.0
HKD3_k127_3472351_1 histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 522.0
HKD3_k127_3472351_10 Glycosyl transferase 4-like - - - 0.000000009374 67.0
HKD3_k127_3472351_11 Calcineurin-like phosphoesterase - - - 0.00007202 54.0
HKD3_k127_3472351_2 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 472.0
HKD3_k127_3472351_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 381.0
HKD3_k127_3472351_4 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 370.0
HKD3_k127_3472351_5 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 336.0
HKD3_k127_3472351_6 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000006548 166.0
HKD3_k127_3472351_7 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000001161 162.0
HKD3_k127_3472351_8 cheY-homologous receiver domain - - - 0.0000000000000000000007621 99.0
HKD3_k127_3472351_9 Pentapeptide repeats (9 copies) - - - 0.0000000001233 74.0
HKD3_k127_3559271_0 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 346.0
HKD3_k127_3559271_1 metal-dependent membrane protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 332.0
HKD3_k127_3559271_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000001822 171.0
HKD3_k127_3559271_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000003391 103.0
HKD3_k127_3559271_4 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000000001048 89.0
HKD3_k127_3559271_5 NnrU protein - - - 0.0001283 47.0
HKD3_k127_3559271_6 NnrU protein - - - 0.0002798 43.0
HKD3_k127_3559271_7 NADPH-dependent FMN reductase - - - 0.0006341 44.0
HKD3_k127_3594716_0 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001814 273.0
HKD3_k127_3594716_1 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000008314 242.0
HKD3_k127_3594716_2 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.000000000000000000000000000000000000000002846 158.0
HKD3_k127_3594716_3 membrane - - - 0.000000000000000002755 94.0
HKD3_k127_3594716_4 - - - - 0.0007058 43.0
HKD3_k127_369268_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 439.0
HKD3_k127_369268_1 Conserved TM helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009034 404.0
HKD3_k127_369268_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 365.0
HKD3_k127_369268_3 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008869 273.0
HKD3_k127_369268_4 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000002596 237.0
HKD3_k127_369268_6 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000003137 138.0
HKD3_k127_369268_7 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000475 83.0
HKD3_k127_369268_8 - - - - 0.00000000002955 70.0
HKD3_k127_369268_9 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000003266 59.0
HKD3_k127_3712324_0 PFAM GCN5-related N-acetyltransferase K03824 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008859 263.0
HKD3_k127_3712324_1 TPR repeat-containing protein - - - 0.00000000000000000000000000000002128 135.0
HKD3_k127_3712324_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000002596 105.0
HKD3_k127_3712324_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000001319 53.0
HKD3_k127_3712324_4 DNA polymerase activity K02319 - 2.7.7.7 0.00001929 51.0
HKD3_k127_37217_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 306.0
HKD3_k127_37217_1 Glutathione S-transferase - - - 0.000000000002318 72.0
HKD3_k127_37217_2 Lamin Tail Domain - - - 0.00000000002359 68.0
HKD3_k127_37217_3 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 0.0004317 43.0
HKD3_k127_3737541_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006834 498.0
HKD3_k127_3737541_1 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 460.0
HKD3_k127_3737541_2 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 287.0
HKD3_k127_3737541_3 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000007005 240.0
HKD3_k127_3737541_4 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000202 124.0
HKD3_k127_3737541_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000003595 63.0
HKD3_k127_3737541_6 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000009169 56.0
HKD3_k127_3740578_0 Protein of unknown function, DUF255 K06888 - - 3.666e-247 780.0
HKD3_k127_3740578_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000002867 99.0
HKD3_k127_376947_0 integrase family K04763 - - 0.00000000000000000000000000000000000000000003011 173.0
HKD3_k127_3800897_0 Dipeptidase K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 344.0
HKD3_k127_3800897_1 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004881 258.0
HKD3_k127_3800897_2 Restriction endonuclease K07448 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005023 239.0
HKD3_k127_3800897_3 membrane protein domain - - - 0.0000000000000000001863 92.0
HKD3_k127_3800897_4 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000002001 85.0
HKD3_k127_3800897_5 Phospholipid methyltransferase - - - 0.00000000000002643 80.0
HKD3_k127_3800897_6 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00003947 48.0
HKD3_k127_3800897_7 SPFH domain-Band 7 family - - - 0.0001038 55.0
HKD3_k127_3812006_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 351.0
HKD3_k127_3812006_1 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000007283 143.0
HKD3_k127_3812006_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000007151 59.0
HKD3_k127_3812375_0 PFAM CBS domain containing protein - - - 0.0000000000000000002299 94.0
HKD3_k127_3812375_1 Tetratricopeptide repeat - - - 0.0000000000000001138 85.0
HKD3_k127_3839142_1 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 304.0
HKD3_k127_3839142_2 response regulator - - - 0.0000001062 60.0
HKD3_k127_3848684_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 292.0
HKD3_k127_3848684_1 radical SAM domain protein - - - 0.000000000000000000000000000000008835 133.0
HKD3_k127_3848684_2 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000001781 116.0
HKD3_k127_3848684_3 Protein of unknown function, DUF488 - - - 0.0000000002181 63.0
HKD3_k127_3848684_5 PFAM Radical SAM domain protein - - - 0.00003002 48.0
HKD3_k127_3848684_6 Fibronectin type III domain - - - 0.00006094 49.0
HKD3_k127_3871762_0 ROK family K00845,K00847,K18673 - 2.7.1.2,2.7.1.4,2.7.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 479.0
HKD3_k127_3871762_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000009065 211.0
HKD3_k127_3871762_2 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000002517 128.0
HKD3_k127_3905759_0 Glycogen debranching enzyme - - - 0.0 1414.0
HKD3_k127_3905759_1 ROK family K00845,K00847,K18673 - 2.7.1.2,2.7.1.4,2.7.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 479.0
HKD3_k127_3905759_2 META domain K03668 - - 0.000000000000000000000000000000000000000001576 168.0
HKD3_k127_3905759_3 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000000000000000008278 150.0
HKD3_k127_3905759_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000006957 84.0
HKD3_k127_3905759_6 membrane protein of uknown function UCP014873 - - - 0.000000000000001227 83.0
HKD3_k127_3905759_7 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00002164 49.0
HKD3_k127_3905759_8 - - - - 0.000945 43.0
HKD3_k127_3921928_0 Nitroreductase family - - - 0.00000000000000000000000000000000001852 142.0
HKD3_k127_3921928_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000005631 55.0
HKD3_k127_3926474_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004134 282.0
HKD3_k127_3926474_1 Domain of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000088 236.0
HKD3_k127_3926474_2 Fumarase C-terminus K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000008274 183.0
HKD3_k127_3926474_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000248 169.0
HKD3_k127_3926474_4 Protein of unknown function (DUF434) - - - 0.000000000000000000000000000000000000001094 155.0
HKD3_k127_4079736_0 PFAM Radical SAM K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 402.0
HKD3_k127_4079736_1 COG3547 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 331.0
HKD3_k127_4079736_2 Glyoxalase-like domain K06996 - - 0.000000000000000000000000000000000007988 139.0
HKD3_k127_4079736_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000002811 130.0
HKD3_k127_4105739_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 548.0
HKD3_k127_4105739_1 peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.0000000000000000000000000000000147 128.0
HKD3_k127_4105739_2 Tryptophan-rich Synechocystis species C-terminal domain - - - 0.00000000000002488 79.0
HKD3_k127_4105739_3 Peptidase C13 family - - - 0.000000007377 62.0
HKD3_k127_4105739_4 UPF0391 membrane protein - - - 0.00004046 47.0
HKD3_k127_4112613_0 E1-E2 ATPase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000686 560.0
HKD3_k127_4112613_1 PFAM CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 486.0
HKD3_k127_4112613_2 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 426.0
HKD3_k127_4112613_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000001355 209.0
HKD3_k127_4112613_4 Glutaredoxin - - - 0.0000000000000000000000000000006559 123.0
HKD3_k127_4153843_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 407.0
HKD3_k127_4153843_1 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 325.0
HKD3_k127_4153843_2 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009491 240.0
HKD3_k127_4153843_3 PFAM Radical SAM - - - 0.000000000000001889 83.0
HKD3_k127_4153843_4 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000344 48.0
HKD3_k127_420260_0 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 525.0
HKD3_k127_420260_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 301.0
HKD3_k127_420260_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000001536 216.0
HKD3_k127_420260_3 Na+/H+ ion antiporter subunit K05569 - - 0.00000000000000000000000000000000000003176 149.0
HKD3_k127_420260_4 Na+/H+ antiporter subunit K05571 - - 0.000000000000000000000000000000001869 131.0
HKD3_k127_420260_5 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000000000000000000000496 98.0
HKD3_k127_420260_6 Domain of unknown function (DUF4040) K05566 - - 0.0000000000000001945 82.0
HKD3_k127_420260_7 Domain of unknown function (DUF4040) K05566 - - 0.000000001481 62.0
HKD3_k127_4220036_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 373.0
HKD3_k127_4220036_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 328.0
HKD3_k127_4220036_10 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000002868 180.0
HKD3_k127_4220036_11 signal transduction protein with CBS domains - - - 0.0000000000000000000000000000000000000000491 158.0
HKD3_k127_4220036_12 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000003736 126.0
HKD3_k127_4220036_2 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 296.0
HKD3_k127_4220036_3 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001629 282.0
HKD3_k127_4220036_4 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003241 264.0
HKD3_k127_4220036_5 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003788 245.0
HKD3_k127_4220036_6 Hit family K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000000000001054 230.0
HKD3_k127_4220036_7 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
HKD3_k127_4220036_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001616 224.0
HKD3_k127_4220036_9 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000002619 194.0
HKD3_k127_4249827_0 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.000000000000000000000000000002259 123.0
HKD3_k127_4249827_1 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000003441 82.0
HKD3_k127_4249827_2 Domain of unknown function (DUF1894) - - - 0.00000002429 57.0
HKD3_k127_4364847_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 594.0
HKD3_k127_4364847_1 by modhmm K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 366.0
HKD3_k127_4364847_2 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000001539 231.0
HKD3_k127_4364847_3 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000000000000001673 167.0
HKD3_k127_4364847_4 - - - - 0.0000000000000000000000001193 111.0
HKD3_k127_4364847_5 Hemerythrin HHE cation binding domain - - - 0.000000000000000002088 94.0
HKD3_k127_4364847_6 Chlorite dismutase - - - 0.0000000000000002669 82.0
HKD3_k127_4364847_7 PFAM RDD domain containing protein - - - 0.00000000000007159 74.0
HKD3_k127_4364847_8 Belongs to the GbsR family - - - 0.0000000000009634 75.0
HKD3_k127_4364847_9 RDD family - - - 0.00000000004698 65.0
HKD3_k127_4369723_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 365.0
HKD3_k127_4369723_1 Flavodoxin domain K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000003803 162.0
HKD3_k127_4399953_0 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 1.607e-215 689.0
HKD3_k127_4399953_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 576.0
HKD3_k127_4399953_10 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000008242 153.0
HKD3_k127_4399953_11 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000001007 161.0
HKD3_k127_4399953_12 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000002247 127.0
HKD3_k127_4399953_13 Permease - - - 0.0000000000000000000000002698 119.0
HKD3_k127_4399953_14 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000004269 117.0
HKD3_k127_4399953_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 485.0
HKD3_k127_4399953_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 461.0
HKD3_k127_4399953_4 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 376.0
HKD3_k127_4399953_5 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 302.0
HKD3_k127_4399953_6 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 287.0
HKD3_k127_4399953_7 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001141 266.0
HKD3_k127_4399953_8 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
HKD3_k127_4399953_9 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000007401 222.0
HKD3_k127_4415861_0 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 328.0
HKD3_k127_4415861_1 Acetyl xylan esterase (AXE1) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001157 252.0
HKD3_k127_4415861_2 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000004163 198.0
HKD3_k127_4415861_3 - - - - 0.0000000000000000000000000000000000002847 145.0
HKD3_k127_4415861_4 - - - - 0.00000000000000000000000000000000001363 139.0
HKD3_k127_4415861_5 - - - - 0.000000000000000000000000000000002358 132.0
HKD3_k127_4415861_6 - - - - 0.0000000000004171 72.0
HKD3_k127_4415861_7 - - - - 0.00000000001408 70.0
HKD3_k127_4415861_8 - - - - 0.0000001332 55.0
HKD3_k127_4415861_9 E1-E2 ATPase K01534 - 3.6.3.3,3.6.3.5 0.00006711 46.0
HKD3_k127_4512914_0 Belongs to the MCM family K10726 - - 5.954e-245 775.0
HKD3_k127_4512914_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002246 252.0
HKD3_k127_4512914_2 pfam nmd3 K07562 - - 0.00000000000000000000000000000000000000000000000000000007804 208.0
HKD3_k127_4512914_3 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000001169 94.0
HKD3_k127_4512914_4 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000008588 92.0
HKD3_k127_4512914_5 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000007448 80.0
HKD3_k127_4512914_6 Belongs to the UPF0218 family K09735 - - 0.00005972 45.0
HKD3_k127_4548320_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.204e-199 631.0
HKD3_k127_4548320_1 PFAM Thiolase K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000125 227.0
HKD3_k127_4548320_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000004171 179.0
HKD3_k127_4548320_3 Sodium:solute symporter family K03307 - - 0.0000000000000000000000000000000000000000000000102 188.0
HKD3_k127_4548320_4 Lrp/AsnC ligand binding domain - - - 0.0000000007439 66.0
HKD3_k127_4548320_5 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.000000006051 59.0
HKD3_k127_4562410_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.307e-208 658.0
HKD3_k127_4562410_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 291.0
HKD3_k127_4562410_2 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000000000002503 167.0
HKD3_k127_4562410_3 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000000000000000000000000003225 123.0
HKD3_k127_4562410_4 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000168 93.0
HKD3_k127_4562410_5 N-ATPase, AtpR subunit - - - 0.0000000000000166 76.0
HKD3_k127_459335_0 helicase activity - - - 3.075e-220 708.0
HKD3_k127_459335_1 PFAM glycoside hydrolase 15-related - - - 7.262e-198 636.0
HKD3_k127_459335_10 Periplasmic copper-binding protein (NosD) - - - 0.00000000001413 78.0
HKD3_k127_459335_11 Purple acid Phosphatase, N-terminal domain - - - 0.00000000846 68.0
HKD3_k127_459335_12 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.000002909 51.0
HKD3_k127_459335_13 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 0.0002845 44.0
HKD3_k127_459335_14 virion core protein (lumpy skin disease virus) - - - 0.0006183 48.0
HKD3_k127_459335_2 PFAM Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 342.0
HKD3_k127_459335_3 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005692 282.0
HKD3_k127_459335_4 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.000000000000000000000000000000000000000000000000000000000000000000000012 254.0
HKD3_k127_459335_5 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000001186 186.0
HKD3_k127_459335_6 Major Facilitator Superfamily - - - 0.000000000000000000000000000000002132 137.0
HKD3_k127_459335_7 - - - - 0.00000000000000000000008835 100.0
HKD3_k127_459335_8 4Fe-4S dicluster domain - - - 0.00000000000000000307 85.0
HKD3_k127_459335_9 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000009898 83.0
HKD3_k127_460479_0 Alpha/beta hydrolase family - GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000000000000000000000000000000000000000000000807 218.0
HKD3_k127_460479_1 membrane - - - 0.0000000000000000000000000000000000001112 151.0
HKD3_k127_460479_2 Phosphoesterase - - - 0.0000000000000000000003779 100.0
HKD3_k127_460479_3 Protein of unknown function (DUF998) - - - 0.00000000000004751 74.0
HKD3_k127_4645464_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 2.996e-211 663.0
HKD3_k127_4645464_1 HMGL-like K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 553.0
HKD3_k127_4645464_10 transcription initiation from RNA polymerase II promoter - - - 0.0001199 44.0
HKD3_k127_4645464_2 Copper amine oxidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006297 260.0
HKD3_k127_4645464_3 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001265 241.0
HKD3_k127_4645464_4 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000006221 225.0
HKD3_k127_4645464_5 binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000001362 212.0
HKD3_k127_4645464_6 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000001526 171.0
HKD3_k127_4645464_7 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.00000000000000000000000001242 113.0
HKD3_k127_4645464_8 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000009803 109.0
HKD3_k127_4645464_9 Peptidase family M48 K03799 - - 0.00000000000000000000005661 99.0
HKD3_k127_46565_0 Glyoxalase-like domain K06996 - - 0.0000000000000003553 81.0
HKD3_k127_46565_1 transcriptional regulator - - - 0.00000000004577 64.0
HKD3_k127_46565_2 Glyoxalase-like domain K06996 - - 0.0000000002039 64.0
HKD3_k127_46565_3 PFAM Telomeric repeat-binding factor 2 - - - 0.0001216 51.0
HKD3_k127_4726735_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000001096 188.0
HKD3_k127_4726735_1 Protein of unknown function (DUF1616) - - - 0.0000000000000000002581 99.0
HKD3_k127_4726735_2 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000007552 68.0
HKD3_k127_473294_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 3.557e-197 626.0
HKD3_k127_473294_1 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 410.0
HKD3_k127_473294_10 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000003447 151.0
HKD3_k127_473294_11 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.00000000000000000000000000000001668 128.0
HKD3_k127_473294_12 Helix-turn-helix XRE-family like proteins K03627 - - 0.0000000000000000000000000000002005 127.0
HKD3_k127_473294_13 PAC2 family K07159 - - 0.0000000000000000000000009852 112.0
HKD3_k127_473294_14 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 0.00000006968 57.0
HKD3_k127_473294_15 nuclease - - - 0.0001425 47.0
HKD3_k127_473294_2 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 370.0
HKD3_k127_473294_3 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 368.0
HKD3_k127_473294_4 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
HKD3_k127_473294_5 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004282 252.0
HKD3_k127_473294_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007725 235.0
HKD3_k127_473294_7 NYN domain - - - 0.00000000000000000000000000000000000000000000000000065 190.0
HKD3_k127_473294_8 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000002619 184.0
HKD3_k127_473294_9 PFAM FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000001266 163.0
HKD3_k127_4753060_0 PFAM ferredoxin-dependent glutamate synthase - - - 4.338e-210 655.0
HKD3_k127_4753060_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 578.0
HKD3_k127_4753060_10 PFAM transferase hexapeptide repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000001341 235.0
HKD3_k127_4753060_11 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000001592 222.0
HKD3_k127_4753060_12 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000001987 212.0
HKD3_k127_4753060_13 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000004496 206.0
HKD3_k127_4753060_14 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000001033 196.0
HKD3_k127_4753060_15 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000001804 198.0
HKD3_k127_4753060_16 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000152 173.0
HKD3_k127_4753060_17 Belongs to the TrpF family K01696,K01817 - 4.2.1.20,5.3.1.24 0.00000000000000000000000000000000000004709 150.0
HKD3_k127_4753060_18 PFAM PQ loop repeat K15383 - - 0.0000000000005771 73.0
HKD3_k127_4753060_19 Pyridoxamine 5'-phosphate oxidase - - - 0.00000397 49.0
HKD3_k127_4753060_2 Protein of unknown function (DUF460) K09150 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 487.0
HKD3_k127_4753060_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 467.0
HKD3_k127_4753060_4 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 398.0
HKD3_k127_4753060_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 366.0
HKD3_k127_4753060_6 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 366.0
HKD3_k127_4753060_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 319.0
HKD3_k127_4753060_8 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 311.0
HKD3_k127_4753060_9 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 297.0
HKD3_k127_4857780_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 473.0
HKD3_k127_4857780_1 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 384.0
HKD3_k127_4857780_10 DsrH like protein K07237 - - 0.00000000000000000002025 93.0
HKD3_k127_4857780_11 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000008595 55.0
HKD3_k127_4857780_2 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 285.0
HKD3_k127_4857780_3 cellular manganese ion homeostasis - - - 0.00000000000000000000000000000000000000000018 163.0
HKD3_k127_4857780_4 DsrE/DsrF-like family K07235 - - 0.0000000000000000000000000000000000000000002273 161.0
HKD3_k127_4857780_5 Tetratricopeptide repeat K12600 - - 0.00000000000000000000000000000000000002271 152.0
HKD3_k127_4857780_6 protein involved in the oxidation of intracellular sulfur K07236 - - 0.000000000000000000000000000000000002155 140.0
HKD3_k127_4857780_7 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.0000000000000000000000000000000001125 137.0
HKD3_k127_4857780_8 toxin-antitoxin pair type II binding - - - 0.0000000000000000000002625 99.0
HKD3_k127_4857780_9 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000001896 106.0
HKD3_k127_4924319_0 Sulfatase K01130 - 3.1.6.1 1.16e-222 723.0
HKD3_k127_4924319_1 Iron-sulfur cluster-binding domain K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 575.0
HKD3_k127_4924319_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 382.0
HKD3_k127_4924319_3 methyltransferase - - - 0.000000000000000000000000000000000000000004216 159.0
HKD3_k127_4924319_4 integrase family K04763 - - 0.000000000000000000000005895 104.0
HKD3_k127_4924319_5 - - - - 0.000000000000006966 80.0
HKD3_k127_4924319_6 integrase family K04763 - - 0.0000000007448 61.0
HKD3_k127_4924319_7 - - - - 0.0000001632 53.0
HKD3_k127_4924319_8 - - - - 0.000007411 49.0
HKD3_k127_4925632_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1076.0
HKD3_k127_4925632_1 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 304.0
HKD3_k127_4925632_2 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 298.0
HKD3_k127_4925632_3 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000184 299.0
HKD3_k127_4925632_4 Source PGD - - - 0.00000000000000000000000000000000000000000009813 171.0
HKD3_k127_4925632_5 acetyltransferase - - - 0.0000000000000000000000000000002098 131.0
HKD3_k127_4925632_6 - - - - 0.0000000000000009905 84.0
HKD3_k127_4925632_7 Uncharacterized conserved protein (DUF2173) - - - 0.0000000001188 67.0
HKD3_k127_4933609_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 2.144e-238 749.0
HKD3_k127_4933609_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 1.598e-202 642.0
HKD3_k127_4933609_10 PINc domain ribonuclease K09006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
HKD3_k127_4933609_11 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003811 283.0
HKD3_k127_4933609_12 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000002693 236.0
HKD3_k127_4933609_13 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000000000001852 222.0
HKD3_k127_4933609_14 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000003082 224.0
HKD3_k127_4933609_15 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000005184 208.0
HKD3_k127_4933609_16 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000001324 206.0
HKD3_k127_4933609_17 Necessary for normal cell division and for the maintenance of normal septation - - - 0.000000000000000000000000000000000000000000000000000000004331 204.0
HKD3_k127_4933609_18 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000003914 158.0
HKD3_k127_4933609_19 Rubrerythrin - - - 0.000000000000000000000000000000000000000007688 156.0
HKD3_k127_4933609_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 544.0
HKD3_k127_4933609_20 - - - - 0.0000000000000000000000000614 109.0
HKD3_k127_4933609_21 Fe-S-cluster oxidoreductase K06940 - - 0.00000001406 63.0
HKD3_k127_4933609_22 Transposase DDE domain - - - 0.00004968 51.0
HKD3_k127_4933609_3 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 495.0
HKD3_k127_4933609_4 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 463.0
HKD3_k127_4933609_5 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006216 454.0
HKD3_k127_4933609_6 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 435.0
HKD3_k127_4933609_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 421.0
HKD3_k127_4933609_8 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 404.0
HKD3_k127_4933609_9 PFAM Linocin_M18 bacteriocin protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 319.0
HKD3_k127_4957484_0 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004596 480.0
HKD3_k127_4957484_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009842 321.0
HKD3_k127_4957484_2 Arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009938 286.0
HKD3_k127_4957484_3 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000004029 261.0
HKD3_k127_4957484_4 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000001191 204.0
HKD3_k127_4957484_5 MazG nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000002355 117.0
HKD3_k127_5005835_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 353.0
HKD3_k127_5005835_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 312.0
HKD3_k127_5005835_2 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002184 272.0
HKD3_k127_5005835_3 Bacterial PH domain - - - 0.0000000000000000000000000000001311 129.0
HKD3_k127_5136823_0 Sulfate permease K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 456.0
HKD3_k127_5136823_1 Universal stress protein family - - - 0.000000000000000000000000004219 115.0
HKD3_k127_5136823_2 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000007075 81.0
HKD3_k127_5151957_0 Glycosyltransferase 28 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 384.0
HKD3_k127_5151957_1 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 376.0
HKD3_k127_5151957_2 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.0000000000000000000000000000002098 132.0
HKD3_k127_5151957_3 Flavodoxin - - - 0.00000000000000000000003164 104.0
HKD3_k127_518512_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 572.0
HKD3_k127_518512_1 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 482.0
HKD3_k127_518512_2 Beta-eliminating lyase K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 443.0
HKD3_k127_518512_3 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009233 408.0
HKD3_k127_518512_4 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.000000000000000000000001384 105.0
HKD3_k127_5195404_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 4.063e-277 869.0
HKD3_k127_5195404_1 Starch synthase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 433.0
HKD3_k127_5195404_2 PFAM peptidase M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008998 286.0
HKD3_k127_5195404_3 Dodecin K09165 - - 0.000000000000000815 78.0
HKD3_k127_5195404_4 COG3547 Transposase and inactivated derivatives - - - 0.0000000000002225 72.0
HKD3_k127_5195404_5 COG3547 Transposase and inactivated derivatives - - - 0.000000000002113 72.0
HKD3_k127_5195404_6 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000002959 56.0
HKD3_k127_5246424_0 ABC-type transporter, periplasmic subunit family 3 K01489 - 3.5.4.5 0.00000000000000000000000000000000000000000000003577 174.0
HKD3_k127_5246424_1 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000000000000005925 162.0
HKD3_k127_5246424_2 PFAM extracellular solute-binding protein family 3 K02030 - - 0.000000000000000000000000000000000000002581 151.0
HKD3_k127_5246424_3 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - 0.000000008293 61.0
HKD3_k127_5246424_4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. It is involved in the biological process described with carbohydrate metabolic process - GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008061,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046348,GO:0071704,GO:0097367,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.0009063 51.0
HKD3_k127_5291455_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.367e-223 704.0
HKD3_k127_5291455_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 288.0
HKD3_k127_5291455_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000004837 217.0
HKD3_k127_5291455_3 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000306 209.0
HKD3_k127_5291455_4 PFAM beta-lactamase domain protein - - - 0.000000000000000000000001297 110.0
HKD3_k127_5303671_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 338.0
HKD3_k127_5303671_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000009999 147.0
HKD3_k127_5303671_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000283 104.0
HKD3_k127_5309929_0 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 615.0
HKD3_k127_5309929_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 530.0
HKD3_k127_5309929_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 358.0
HKD3_k127_5309929_3 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 321.0
HKD3_k127_5309929_4 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 317.0
HKD3_k127_5309929_5 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000006095 239.0
HKD3_k127_5309929_6 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000002902 226.0
HKD3_k127_5309929_7 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000000003962 141.0
HKD3_k127_5309929_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000001297 136.0
HKD3_k127_5309929_9 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000002015 98.0
HKD3_k127_5315708_0 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002555 258.0
HKD3_k127_5315708_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000003901 200.0
HKD3_k127_5320092_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 467.0
HKD3_k127_5320092_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002677 249.0
HKD3_k127_5320092_2 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000001218 100.0
HKD3_k127_5343814_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 1.141e-201 636.0
HKD3_k127_5343814_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 364.0
HKD3_k127_5343814_2 CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000000000000002444 185.0
HKD3_k127_5343814_3 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000009083 132.0
HKD3_k127_5343814_4 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000004509 77.0
HKD3_k127_5343814_5 - - - - 0.0000000000006403 72.0
HKD3_k127_5343814_6 - - - - 0.000000007847 58.0
HKD3_k127_5355487_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 596.0
HKD3_k127_5355487_1 Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) K00672 - 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 288.0
HKD3_k127_5355487_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003453 275.0
HKD3_k127_5355487_3 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000001697 82.0
HKD3_k127_5368319_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 557.0
HKD3_k127_5368319_1 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000003992 126.0
HKD3_k127_5368319_2 Adenosylcobinamide amidohydrolase K08260 - 3.5.1.90 0.00000000000000000000002045 108.0
HKD3_k127_5368319_3 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000001453 70.0
HKD3_k127_5368319_4 beta-fructofuranosidase activity - - - 0.0000009893 57.0
HKD3_k127_5369515_0 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000004625 148.0
HKD3_k127_5369515_1 transposition, DNA-mediated - - - 0.000000000000000000000000000000000453 136.0
HKD3_k127_5369515_2 Sulfite exporter TauE/SafE K07090 - - 0.0000000000005139 73.0
HKD3_k127_5369515_3 hmm pf01609 - - - 0.00000003899 57.0
HKD3_k127_5369515_4 Sulfite exporter TauE/SafE K07090 - - 0.00000108 53.0
HKD3_k127_5392385_0 COG1226 Kef-type K transport systems - - - 0.0000000000000000000000000000000000000000000000000000000000000002071 241.0
HKD3_k127_5392385_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000007345 202.0
HKD3_k127_5392385_3 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000001739 89.0
HKD3_k127_5392385_4 PFAM Periplasmic copper-binding protein (NosD) K07218 - - 0.000000004217 68.0
HKD3_k127_5392385_5 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.000000006902 59.0
HKD3_k127_5398168_0 PFAM alpha amylase catalytic region - - - 4.594e-266 832.0
HKD3_k127_5398168_1 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 559.0
HKD3_k127_5398168_10 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001416 272.0
HKD3_k127_5398168_11 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001284 263.0
HKD3_k127_5398168_12 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000001756 232.0
HKD3_k127_5398168_13 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000001286 207.0
HKD3_k127_5398168_14 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000003372 157.0
HKD3_k127_5398168_15 Arsenite-activated ATPase ArsA K01551 - 3.6.3.16 0.00000000000000000000000000000000002956 146.0
HKD3_k127_5398168_16 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000007587 125.0
HKD3_k127_5398168_17 RDD family - - - 0.00000000000000000006211 95.0
HKD3_k127_5398168_18 - - - - 0.000000000000000007874 86.0
HKD3_k127_5398168_19 tetratricopeptide repeat - - - 0.0000000000001243 78.0
HKD3_k127_5398168_2 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 490.0
HKD3_k127_5398168_20 TPR repeat-containing protein - - - 0.0000001286 56.0
HKD3_k127_5398168_21 COG1522 Transcriptional regulators - - - 0.0000003559 55.0
HKD3_k127_5398168_22 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0001746 44.0
HKD3_k127_5398168_3 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 470.0
HKD3_k127_5398168_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 405.0
HKD3_k127_5398168_5 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000931 331.0
HKD3_k127_5398168_6 PFAM sodium calcium exchanger membrane region K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 317.0
HKD3_k127_5398168_7 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 295.0
HKD3_k127_5398168_8 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001187 277.0
HKD3_k127_5398168_9 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001078 270.0
HKD3_k127_5448022_0 Belongs to the dihydrofolate reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 320.0
HKD3_k127_5448022_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000001685 213.0
HKD3_k127_5448022_2 homolog of gamma-carboxymuconolactone decarboxylase subunit - - - 0.00000000000000000000000000000000000000007852 155.0
HKD3_k127_5448022_3 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000001922 65.0
HKD3_k127_5556542_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1120.0
HKD3_k127_5556542_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 502.0
HKD3_k127_5556542_10 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000001431 238.0
HKD3_k127_5556542_11 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000004761 210.0
HKD3_k127_5556542_12 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.000000000000000000000000000000000000000000000000908 180.0
HKD3_k127_5556542_13 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000001005 134.0
HKD3_k127_5556542_14 4Fe-4S binding domain - - - 0.000000000000000000000000001536 113.0
HKD3_k127_5556542_15 Ribosomal protein S27E K02978 - - 0.000000000000000003396 85.0
HKD3_k127_5556542_16 protein conserved in archaea K09723 - - 0.00000000000000009618 87.0
HKD3_k127_5556542_17 4Fe-4S dicluster domain - - - 0.00000000000003972 74.0
HKD3_k127_5556542_18 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000001151 68.0
HKD3_k127_5556542_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 477.0
HKD3_k127_5556542_3 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 362.0
HKD3_k127_5556542_4 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 355.0
HKD3_k127_5556542_5 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 336.0
HKD3_k127_5556542_6 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 312.0
HKD3_k127_5556542_7 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 311.0
HKD3_k127_5556542_8 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 312.0
HKD3_k127_5556542_9 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007381 282.0
HKD3_k127_5558744_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 6.631e-226 715.0
HKD3_k127_5558744_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 544.0
HKD3_k127_5558744_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 387.0
HKD3_k127_5558744_3 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 330.0
HKD3_k127_5558744_4 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000004729 226.0
HKD3_k127_5558744_5 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000000000000000000000000000005286 217.0
HKD3_k127_5558744_6 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000008247 213.0
HKD3_k127_5558744_7 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000002421 180.0
HKD3_k127_5558744_8 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000003595 103.0
HKD3_k127_562838_0 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001796 204.0
HKD3_k127_562838_1 Domain of unknown function (DUF3786) - - - 0.0000000000000003446 85.0
HKD3_k127_562838_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000001897 76.0
HKD3_k127_5637072_0 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009596 302.0
HKD3_k127_5637072_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000003401 80.0
HKD3_k127_5683188_0 Flavoprotein K18853 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0042558,GO:0042559,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901283,GO:1901285,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:2001115,GO:2001116,GO:2001117,GO:2001118 1.5.99.15 0.000000000000000000000000000000000000000000000000000000000000000003552 233.0
HKD3_k127_5683188_1 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000002232 143.0
HKD3_k127_5683188_2 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.000000000000000000000000000000005292 134.0
HKD3_k127_5683188_3 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000001102 102.0
HKD3_k127_5683188_5 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.00000000001362 74.0
HKD3_k127_5683188_6 membrane protein of uknown function UCP014873 - - - 0.0004631 45.0
HKD3_k127_5683221_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 394.0
HKD3_k127_5683221_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000003151 59.0
HKD3_k127_5683221_2 Chagasin family peptidase inhibitor I42 K14475 - - 0.0009509 49.0
HKD3_k127_569581_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 531.0
HKD3_k127_569581_1 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000002575 141.0
HKD3_k127_569581_2 - - - - 0.000000000000000000000000000000000007617 147.0
HKD3_k127_569581_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000002706 116.0
HKD3_k127_569581_4 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.000000005514 59.0
HKD3_k127_5783916_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009269 356.0
HKD3_k127_5783916_1 Ribbon-helix-helix protein, copG family - - - 0.00000000000000000000000000000000000000000000000000000005516 200.0
HKD3_k127_5783916_2 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000001158 117.0
HKD3_k127_5783916_3 4Fe-4S binding domain K12143 - - 0.000002982 55.0
HKD3_k127_5806071_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 537.0
HKD3_k127_5806071_1 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000001085 186.0
HKD3_k127_5806071_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000001437 159.0
HKD3_k127_5806071_3 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000001769 157.0
HKD3_k127_5806071_4 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000002394 91.0
HKD3_k127_5837923_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 563.0
HKD3_k127_5837923_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 482.0
HKD3_k127_5837923_2 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 411.0
HKD3_k127_5837923_3 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 385.0
HKD3_k127_5837923_4 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 370.0
HKD3_k127_5837923_5 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 317.0
HKD3_k127_5837923_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.000000000000000000000000000000000000006345 147.0
HKD3_k127_5853628_0 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 465.0
HKD3_k127_5853628_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 440.0
HKD3_k127_5853628_10 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000005861 76.0
HKD3_k127_5853628_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 396.0
HKD3_k127_5853628_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 378.0
HKD3_k127_5853628_4 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 317.0
HKD3_k127_5853628_5 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 289.0
HKD3_k127_5853628_6 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001117 237.0
HKD3_k127_5853628_7 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000005021 165.0
HKD3_k127_5853628_8 Belongs to the UPF0216 family K09737 - - 0.0000000000000000009365 91.0
HKD3_k127_5853628_9 - - - - 0.0000000000000001138 85.0
HKD3_k127_5864349_0 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003493 265.0
HKD3_k127_5864349_1 pyrroloquinoline quinone binding - - - 0.000000000000028 87.0
HKD3_k127_5921196_0 Involved in cell shape control K22222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 328.0
HKD3_k127_5921196_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 315.0
HKD3_k127_5921196_2 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 291.0
HKD3_k127_5921196_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000004054 260.0
HKD3_k127_5921196_4 metal ion binding - - - 0.000000000000000000000000001587 117.0
HKD3_k127_5921196_5 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000001066 100.0
HKD3_k127_5921196_6 Periplasmic copper-binding protein (NosD) K07218 - - 0.000000000006522 78.0
HKD3_k127_5921196_7 - - - - 0.000003223 59.0
HKD3_k127_6010128_0 Uncharacterized conserved protein (DUF2299) - - - 0.0000000000000000000000000000000000000000003584 163.0
HKD3_k127_6010128_1 PFAM peptidase - - - 0.000000000000003123 76.0
HKD3_k127_6010128_2 PFAM peptidase - - - 0.0000000003386 60.0
HKD3_k127_6010128_3 PFAM peptidase - - - 0.0000006418 51.0
HKD3_k127_6010128_4 Phage plasmid primase, P4 family K06919 - - 0.000006607 51.0
HKD3_k127_6010128_5 - - - - 0.00001045 57.0
HKD3_k127_6010128_6 Peptidase family M50 - - - 0.00008558 47.0
HKD3_k127_6040947_0 Glycogen debranching enzyme - - - 8.16e-217 679.0
HKD3_k127_6040947_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 568.0
HKD3_k127_6040947_2 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 388.0
HKD3_k127_6040947_3 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 341.0
HKD3_k127_6040947_4 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 289.0
HKD3_k127_6040947_5 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000004437 176.0
HKD3_k127_6040947_6 protein conserved in archaea - - - 0.0000000000000000000000000004665 116.0
HKD3_k127_6040947_7 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000008487 76.0
HKD3_k127_6040947_8 Short C-terminal domain - - - 0.000000009491 58.0
HKD3_k127_6061043_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 303.0
HKD3_k127_6061043_1 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 289.0
HKD3_k127_6061043_10 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000001072 124.0
HKD3_k127_6061043_11 Belongs to the UPF0147 family K09721 - - 0.0000000000000000000000000004604 115.0
HKD3_k127_6061043_12 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.000000001291 64.0
HKD3_k127_6061043_2 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 288.0
HKD3_k127_6061043_3 peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002371 291.0
HKD3_k127_6061043_4 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000002853 224.0
HKD3_k127_6061043_5 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000001394 209.0
HKD3_k127_6061043_6 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000002927 193.0
HKD3_k127_6061043_7 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.000000000000000000000000000000000000000002611 162.0
HKD3_k127_6061043_8 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.0000000000000000000000000000000000000004514 166.0
HKD3_k127_6061043_9 - - - - 0.00000000000000000000000000000000001254 142.0
HKD3_k127_6074693_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009063 565.0
HKD3_k127_6074693_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 452.0
HKD3_k127_6074693_10 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000385 198.0
HKD3_k127_6074693_11 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000005786 137.0
HKD3_k127_6074693_12 Polysaccharide deacetylase - - - 0.00000000000000000000000000001483 128.0
HKD3_k127_6074693_13 acetyltransferase - - - 0.000000000000000000000000003311 122.0
HKD3_k127_6074693_14 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000006258 97.0
HKD3_k127_6074693_15 polygalacturonase activity - - - 0.0000000003068 64.0
HKD3_k127_6074693_16 Methyltransferase domain - - - 0.000000003857 67.0
HKD3_k127_6074693_2 ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 438.0
HKD3_k127_6074693_3 asparagine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 307.0
HKD3_k127_6074693_4 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 286.0
HKD3_k127_6074693_5 Protein involved in cellulose biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000008016 246.0
HKD3_k127_6074693_6 transferase activity, transferring glycosyl groups K07011,K13659 - 2.4.1.264 0.000000000000000000000000000000000000000000000000000000000000000005928 241.0
HKD3_k127_6074693_7 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000001604 235.0
HKD3_k127_6074693_8 transferase activity, transferring glycosyl groups K07011,K13659 - 2.4.1.264 0.0000000000000000000000000000000000000000000000000000000000001878 226.0
HKD3_k127_6074693_9 Protein of unknown function (DUF354) K09726 - - 0.0000000000000000000000000000000000000000000000000000000000009935 222.0
HKD3_k127_6132468_0 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 580.0
HKD3_k127_6132468_1 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 432.0
HKD3_k127_6132468_11 Chaperone of endosialidase - - - 0.00000000000001263 83.0
HKD3_k127_6132468_12 Phosphoserine phosphatase - - - 0.0000000000009138 79.0
HKD3_k127_6132468_13 - - - - 0.00000003423 62.0
HKD3_k127_6132468_2 PFAM ABC transporter related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 355.0
HKD3_k127_6132468_3 PFAM cobalamin synthesis protein P47K - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 352.0
HKD3_k127_6132468_4 PFAM Fe-S cluster domain protein K06939 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001796 255.0
HKD3_k127_6132468_5 sulfopyruvate decarboxylase, alpha subunit K06034 - 4.1.1.79 0.000000000000000000000000000000000000000000000000000001845 196.0
HKD3_k127_6132468_6 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.00000000000000000000000000000000000000000000001633 175.0
HKD3_k127_6132468_7 - - - - 0.0000000000000000000000000000000000000000000000364 177.0
HKD3_k127_6132468_8 Domain of unknown function (DUF4870) K09940 - - 0.00000000000000000000000000002969 122.0
HKD3_k127_6132468_9 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase K19302 - 3.6.1.27 0.00000000000000000000239 102.0
HKD3_k127_6141626_0 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000007104 185.0
HKD3_k127_6141626_1 DDE superfamily endonuclease - - - 0.000000000000000003866 85.0
HKD3_k127_6141626_2 Uncharacterised BCR, YnfA/UPF0060 family K09771 - - 0.000000000006031 66.0
HKD3_k127_6141626_3 PFAM Uncharacterised BCR, YnfA UPF0060 family K09771 - - 0.000000000009931 68.0
HKD3_k127_6141626_4 Copper binding proteins, plastocyanin/azurin family - - - 0.0000008514 52.0
HKD3_k127_6147759_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 434.0
HKD3_k127_6147759_1 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 351.0
HKD3_k127_6147759_10 Belongs to the UPF0248 family K09715 - - 0.0000000000000000002436 90.0
HKD3_k127_6147759_11 SOUL heme-binding protein - - - 0.000000000000000005377 91.0
HKD3_k127_6147759_12 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000006692 79.0
HKD3_k127_6147759_13 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.000000002251 59.0
HKD3_k127_6147759_2 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 306.0
HKD3_k127_6147759_3 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003683 284.0
HKD3_k127_6147759_4 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005697 241.0
HKD3_k127_6147759_5 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000000000000000000000000000000000000002551 235.0
HKD3_k127_6147759_6 - - - - 0.0000000000000000000000000000000000000000001826 172.0
HKD3_k127_6147759_7 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000272 156.0
HKD3_k127_6147759_8 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000002978 132.0
HKD3_k127_6147759_9 eRF1 domain 2 - - - 0.000000000000000000000000116 118.0
HKD3_k127_6201083_0 PFAM Pentapeptide repeats (8 copies) - - - 0.00000000001501 73.0
HKD3_k127_6204715_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008022 530.0
HKD3_k127_6204715_1 DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001035 276.0
HKD3_k127_6204715_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001748 258.0
HKD3_k127_6225402_0 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 371.0
HKD3_k127_6225402_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 304.0
HKD3_k127_6225402_10 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000003704 70.0
HKD3_k127_6225402_11 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.00000000005635 65.0
HKD3_k127_6225402_12 Periplasmic copper-binding protein (NosD) - - - 0.000000244 60.0
HKD3_k127_6225402_13 TIGRFAM PAS sensor protein - - - 0.000002238 51.0
HKD3_k127_6225402_14 RibD C-terminal domain - - - 0.000002641 51.0
HKD3_k127_6225402_15 DDE superfamily endonuclease - - - 0.000007562 48.0
HKD3_k127_6225402_16 small metal-binding protein - - - 0.0006314 45.0
HKD3_k127_6225402_17 YHS domain - - - 0.000959 47.0
HKD3_k127_6225402_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006571 257.0
HKD3_k127_6225402_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001088 254.0
HKD3_k127_6225402_4 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000003409 192.0
HKD3_k127_6225402_5 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000007225 147.0
HKD3_k127_6225402_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000002906 139.0
HKD3_k127_6225402_7 Histidine kinase - - - 0.000000000000000000000000000002352 129.0
HKD3_k127_6225402_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000003117 101.0
HKD3_k127_6225402_9 - - - - 0.00000000001152 70.0
HKD3_k127_6245091_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1233.0
HKD3_k127_6245091_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
HKD3_k127_6245091_2 LUD domain - - - 0.0000000000000000000000000000000000000000000000000000000000001776 218.0
HKD3_k127_6245091_3 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000008595 152.0
HKD3_k127_6245091_4 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.000000000000000007957 85.0
HKD3_k127_6245091_5 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.2.1.59 0.0000000000000001012 92.0
HKD3_k127_6272249_0 PFAM Cache, type 2 domain protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000006168 236.0
HKD3_k127_6272249_1 - - - - 0.000000000000000000000000000000000000000237 153.0
HKD3_k127_6272249_2 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000004626 133.0
HKD3_k127_6272249_3 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000002484 111.0
HKD3_k127_6272249_4 - - - - 0.000000000000001351 82.0
HKD3_k127_6272249_5 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.0000000000415 64.0
HKD3_k127_6297913_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1030.0
HKD3_k127_6297913_1 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 361.0
HKD3_k127_6297913_2 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000004531 150.0
HKD3_k127_6307509_0 CoA binding domain - - - 9.464e-255 803.0
HKD3_k127_6307509_1 ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 2.939e-230 729.0
HKD3_k127_6307509_10 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000004094 205.0
HKD3_k127_6307509_11 integral membrane protein K07027 - - 0.00000000000000000000000000000000000000000000000009099 191.0
HKD3_k127_6307509_12 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000001152 181.0
HKD3_k127_6307509_13 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000005594 174.0
HKD3_k127_6307509_14 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000000001859 123.0
HKD3_k127_6307509_15 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000001995 111.0
HKD3_k127_6307509_16 PBS lyase HEAT-like repeat - - - 0.0000000000000000000001715 109.0
HKD3_k127_6307509_17 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000001448 101.0
HKD3_k127_6307509_18 Binds to the 23S rRNA K02896 - - 0.0000000000000000009532 86.0
HKD3_k127_6307509_19 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000004115 67.0
HKD3_k127_6307509_2 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.916e-198 630.0
HKD3_k127_6307509_20 Family of unknown function (DUF5350) - - - 0.000000000005849 67.0
HKD3_k127_6307509_21 - - - - 0.0000000258 64.0
HKD3_k127_6307509_22 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000114 55.0
HKD3_k127_6307509_23 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000004719 53.0
HKD3_k127_6307509_24 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00006767 49.0
HKD3_k127_6307509_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 529.0
HKD3_k127_6307509_4 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 486.0
HKD3_k127_6307509_5 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 415.0
HKD3_k127_6307509_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001958 259.0
HKD3_k127_6307509_7 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001533 248.0
HKD3_k127_6307509_8 DNA polymerase Ligase (LigD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006438 235.0
HKD3_k127_6328788_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000244 204.0
HKD3_k127_6328788_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000009179 96.0
HKD3_k127_6346757_0 Domain of unknown function (DUF1947) K07575 - - 0.0000000000000000000000000000000000000006445 153.0
HKD3_k127_6346757_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000006683 149.0
HKD3_k127_6346757_2 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000361 112.0
HKD3_k127_6346757_3 binds to the 23S rRNA K02922 - - 0.0000000000000000005871 87.0
HKD3_k127_6346757_4 Stage II sporulation protein M - - - 0.000000001686 66.0
HKD3_k127_6358654_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 318.0
HKD3_k127_6358654_1 COG0569 K transport systems, NAD-binding component K03499 - - 0.000004706 51.0
HKD3_k127_6385745_0 oligoendopeptidase F K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 503.0
HKD3_k127_6385745_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000001124 66.0
HKD3_k127_6385745_2 amino acid K02030 - - 0.0000005434 60.0
HKD3_k127_6405460_0 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 339.0
HKD3_k127_6405460_1 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001043 254.0
HKD3_k127_6405460_2 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000004137 246.0
HKD3_k127_6405460_3 Ion channel K10716 - - 0.0000000000000000000000000000000003493 137.0
HKD3_k127_6405460_4 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000004101 106.0
HKD3_k127_6405460_5 Ion channel K10716 - - 0.00000000000000001799 86.0
HKD3_k127_6417623_0 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 446.0
HKD3_k127_6417623_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000022 272.0
HKD3_k127_6417623_2 Methyltransferase domain - - - 0.000000000000000000000000000000001341 136.0
HKD3_k127_6417623_3 Uncharacterized conserved protein (DUF2173) - - - 0.000000000000000000000000000002699 122.0
HKD3_k127_6417623_4 Protein of unknown function (DUF2769) - - - 0.000000000000000003686 87.0
HKD3_k127_6417623_5 methyltransferase - - - 0.0000000000000009461 80.0
HKD3_k127_6417623_6 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000002618 61.0
HKD3_k127_6417623_7 4Fe-4S dicluster domain - - - 0.000000005574 58.0
HKD3_k127_6417623_8 transposition, DNA-mediated - - - 0.0000000715 55.0
HKD3_k127_6417623_9 transposition, DNA-mediated - - - 0.0003718 44.0
HKD3_k127_6455708_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1556.0
HKD3_k127_6455708_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1052.0
HKD3_k127_6455708_10 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000001063 202.0
HKD3_k127_6455708_11 TIGRFAM DJ-1 family protein K03152 - 3.5.1.124 0.000000000000000000000000000000000000000000004188 169.0
HKD3_k127_6455708_12 Thioredoxin - - - 0.000000000000000000000000000000000000003251 149.0
HKD3_k127_6455708_13 Transposase domain (DUF772) K07481 - - 0.00000000000000000000001617 104.0
HKD3_k127_6455708_14 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000003636 108.0
HKD3_k127_6455708_15 Transposase domain (DUF772) K07481 - - 0.0000000000000000001967 92.0
HKD3_k127_6455708_16 - - - - 0.00000000000005541 75.0
HKD3_k127_6455708_17 Transposase domain (DUF772) K07481 - - 0.0000000002295 64.0
HKD3_k127_6455708_18 Transposase domain (DUF772) K07481 - - 0.000000004375 58.0
HKD3_k127_6455708_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 8.841e-234 733.0
HKD3_k127_6455708_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.299e-229 719.0
HKD3_k127_6455708_4 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 602.0
HKD3_k127_6455708_5 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 479.0
HKD3_k127_6455708_6 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 341.0
HKD3_k127_6455708_7 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
HKD3_k127_6455708_8 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000001695 216.0
HKD3_k127_6455708_9 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000001482 202.0
HKD3_k127_6457455_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 434.0
HKD3_k127_6457455_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 335.0
HKD3_k127_6457455_2 PFAM Chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002248 284.0
HKD3_k127_6457455_3 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006021 244.0
HKD3_k127_6457455_4 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000008588 177.0
HKD3_k127_6458729_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 4.466e-277 866.0
HKD3_k127_6458729_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 462.0
HKD3_k127_6458729_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 432.0
HKD3_k127_6458729_3 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000007793 183.0
HKD3_k127_6458729_4 AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000005111 113.0
HKD3_k127_6458729_5 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000007858 103.0
HKD3_k127_6461411_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 533.0
HKD3_k127_6461411_1 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 501.0
HKD3_k127_6461411_2 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009555 440.0
HKD3_k127_6461411_3 aconitate hydratase K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 350.0
HKD3_k127_6461411_4 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 355.0
HKD3_k127_6461411_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001182 271.0
HKD3_k127_6461411_6 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000003231 134.0
HKD3_k127_6461411_7 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000001698 128.0
HKD3_k127_6461411_8 Belongs to the UPF0146 family K09713 - - 0.0000000000000000003167 92.0
HKD3_k127_6461411_9 hmm pf01609 - - - 0.00000002064 58.0
HKD3_k127_6497367_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1301.0
HKD3_k127_6497367_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 416.0
HKD3_k127_6497367_2 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 380.0
HKD3_k127_6497367_3 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 345.0
HKD3_k127_6497367_4 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000005538 201.0
HKD3_k127_6497367_5 methyltransferase activity - - - 0.0000000000000000000000000005076 119.0
HKD3_k127_6497367_6 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.0000000000000000000003616 97.0
HKD3_k127_6503839_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 494.0
HKD3_k127_6503839_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000002644 178.0
HKD3_k127_6503839_2 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000001119 123.0
HKD3_k127_6503839_3 Protein of unknown function (DUF1232) - - - 0.000000000000000000006185 97.0
HKD3_k127_6503839_4 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000005855 85.0
HKD3_k127_6503839_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.0000000000000000847 84.0
HKD3_k127_6503839_6 - - - - 0.00000000000436 72.0
HKD3_k127_6529498_0 PFAM Prenyltransferase squalene oxidase - - - 1.799e-215 689.0
HKD3_k127_6529498_1 Filamentation induced by cAMP protein fic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 422.0
HKD3_k127_6529498_2 Belongs to the 'phage' integrase family - - - 0.000000000000000000000001077 114.0
HKD3_k127_6529498_3 PFAM Cache, type 2 domain protein - - - 0.00000000000000001918 85.0
HKD3_k127_6529498_4 PFAM Cache, type 2 domain protein K02030 - - 0.0000000000000003697 80.0
HKD3_k127_6529498_5 - - - - 0.000000000001886 72.0
HKD3_k127_6529498_6 - - - - 0.00000000001454 77.0
HKD3_k127_6556695_0 membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 467.0
HKD3_k127_6556695_1 integrase family K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004317 263.0
HKD3_k127_6556695_2 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000001076 212.0
HKD3_k127_6556695_3 PFAM GCN5-related N-acetyltransferase K03824 - - 0.000000000000000000000000000000000000259 143.0
HKD3_k127_6556695_4 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000001973 104.0
HKD3_k127_6556695_5 PFAM GCN5-related N-acetyltransferase K03824 - - 0.0000000000000000000432 91.0
HKD3_k127_6569502_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 498.0
HKD3_k127_6569502_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 426.0
HKD3_k127_6569502_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004402 260.0
HKD3_k127_6569502_11 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007653 246.0
HKD3_k127_6569502_12 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000002768 219.0
HKD3_k127_6569502_13 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000002131 194.0
HKD3_k127_6569502_14 Kelch motif - - - 0.000000000000000000000005704 109.0
HKD3_k127_6569502_15 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.0000000000000001203 82.0
HKD3_k127_6569502_16 PFAM Exonuclease VII small subunit K03602 - 3.1.11.6 0.00000000001794 66.0
HKD3_k127_6569502_17 - - - - 0.0000000008987 62.0
HKD3_k127_6569502_2 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 417.0
HKD3_k127_6569502_3 PHP C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 413.0
HKD3_k127_6569502_4 Has ATPase and non-specific DNA-binding activities K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007967 423.0
HKD3_k127_6569502_5 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 395.0
HKD3_k127_6569502_6 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 294.0
HKD3_k127_6569502_7 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 302.0
HKD3_k127_6569502_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000127 284.0
HKD3_k127_6569502_9 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002117 280.0
HKD3_k127_6569832_0 ATP synthase alpha/beta chain, C terminal domain K02111 - 3.6.3.14 4.884e-203 644.0
HKD3_k127_6569832_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008731 532.0
HKD3_k127_6569832_2 ATP synthase K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 298.0
HKD3_k127_6569832_3 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000003323 209.0
HKD3_k127_6569832_4 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000006958 192.0
HKD3_k127_6569832_5 - - - - 0.0000000000000000000000000000000000000000000002882 170.0
HKD3_k127_6569832_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000000000000000000008444 166.0
HKD3_k127_6569832_7 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000001724 162.0
HKD3_k127_6569832_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000002002 130.0
HKD3_k127_658130_0 integrase family K04763 - - 0.000000000000000000000000000000000002507 144.0
HKD3_k127_658130_1 integrase family - - - 0.000000000001359 72.0
HKD3_k127_658130_2 oxidoreductase activity K07114 - - 0.00000005506 64.0
HKD3_k127_6609858_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000009997 229.0
HKD3_k127_6609858_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000117 119.0
HKD3_k127_6609858_2 mRNA binding - - - 0.0000000000000000000004083 96.0
HKD3_k127_6609858_3 Possibly the antitoxin component of a - - - 0.00000000000000000000135 95.0
HKD3_k127_6609858_4 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000001145 78.0
HKD3_k127_6609858_5 HicA toxin of bacterial toxin-antitoxin, - - - 0.000009607 47.0
HKD3_k127_6636313_0 DEAD DEAH box helicase domain protein K05592,K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 555.0
HKD3_k127_6690371_0 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 295.0
HKD3_k127_6690371_2 - K00960 - 2.7.7.6 0.000000000000001359 78.0
HKD3_k127_6690371_3 - - - - 0.00000000000000278 81.0
HKD3_k127_6690371_4 Bacterial regulatory protein, arsR family - - - 0.000000000000003178 79.0
HKD3_k127_6690371_5 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000007831 61.0
HKD3_k127_6690371_6 Pyridoxamine 5'-phosphate oxidase - - - 0.000001775 51.0
HKD3_k127_6690371_7 Pyridoxamine 5'-phosphate oxidase - - - 0.00006935 45.0
HKD3_k127_6690371_8 DNA polymerase activity K02319 - 2.7.7.7 0.0001028 47.0
HKD3_k127_6690371_9 polyketide synthase K00665 GO:0003674,GO:0003824,GO:0004312,GO:0005975,GO:0005976,GO:0005977,GO:0006073,GO:0006082,GO:0006091,GO:0006112,GO:0006629,GO:0006631,GO:0006633,GO:0006638,GO:0006639,GO:0006641,GO:0006723,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009743,GO:0009744,GO:0009987,GO:0010033,GO:0015980,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0034285,GO:0042221,GO:0042335,GO:0043170,GO:0043436,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0045017,GO:0046394,GO:0046460,GO:0046463,GO:0046486,GO:0048856,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071324,GO:0071329,GO:0071704,GO:0072330,GO:0097089,GO:1901576,GO:1901700,GO:1901701,GO:1902321 2.3.1.85 0.0004512 44.0
HKD3_k127_6701051_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 5.506e-214 672.0
HKD3_k127_6701051_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 574.0
HKD3_k127_6701051_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 576.0
HKD3_k127_6701051_3 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 347.0
HKD3_k127_6701051_4 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 297.0
HKD3_k127_6701051_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000003219 206.0
HKD3_k127_6701051_6 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000004098 158.0
HKD3_k127_6701051_7 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000002951 143.0
HKD3_k127_6701051_8 Gar1/Naf1 RNA binding region K07569 - - 0.00000000007411 66.0
HKD3_k127_6701051_9 Transposase domain (DUF772) K07481 - - 0.000000001039 59.0
HKD3_k127_6740098_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.128e-212 672.0
HKD3_k127_6740098_1 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 527.0
HKD3_k127_6740098_10 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
HKD3_k127_6740098_11 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009957 266.0
HKD3_k127_6740098_12 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000003619 255.0
HKD3_k127_6740098_13 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000001218 252.0
HKD3_k127_6740098_14 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.0000000000000000000000000000000000000000000000000000000000000000003294 235.0
HKD3_k127_6740098_15 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000001197 227.0
HKD3_k127_6740098_16 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000004608 196.0
HKD3_k127_6740098_17 RNA-binding protein of the translin family K07477 - - 0.0000000000000000000000000000000000000000000000000001773 192.0
HKD3_k127_6740098_18 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000005372 169.0
HKD3_k127_6740098_19 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000003746 150.0
HKD3_k127_6740098_2 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 503.0
HKD3_k127_6740098_20 adenyl ribonucleotide binding - - - 0.0000000000000000000001172 104.0
HKD3_k127_6740098_21 - - - - 0.000000000000000001001 94.0
HKD3_k127_6740098_22 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000004175 84.0
HKD3_k127_6740098_23 6-phosphogluconolactonase activity - - - 0.000000000000001048 89.0
HKD3_k127_6740098_24 CHAT domain - - - 0.0000000003282 74.0
HKD3_k127_6740098_25 Transposase domain (DUF772) K07481 - - 0.000000006681 57.0
HKD3_k127_6740098_26 Transposase - - - 0.0000143 51.0
HKD3_k127_6740098_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 409.0
HKD3_k127_6740098_4 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 397.0
HKD3_k127_6740098_5 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 336.0
HKD3_k127_6740098_6 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 317.0
HKD3_k127_6740098_7 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
HKD3_k127_6740098_8 PFAM Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002102 273.0
HKD3_k127_6740098_9 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000005303 267.0
HKD3_k127_676890_0 - - - - 4.627e-228 723.0
HKD3_k127_676890_1 PFAM ribonuclease II K01147 - 3.1.13.1 8.924e-199 631.0
HKD3_k127_676890_2 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.00000000000000000000000000000000000000001209 156.0
HKD3_k127_676890_3 transcription activator, effector binding - - - 0.000000000000000000000000000000000000001851 168.0
HKD3_k127_676890_4 PFAM Fibronectin type III domain - - - 0.000000000000000000000000000000000000006767 162.0
HKD3_k127_676890_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000002416 85.0
HKD3_k127_676890_6 RHS Repeat - - - 0.0001542 50.0
HKD3_k127_6913596_0 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
HKD3_k127_6913596_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000001157 162.0
HKD3_k127_6913596_2 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000001146 149.0
HKD3_k127_6913596_3 - - - - 0.000000000000000000000000000002963 123.0
HKD3_k127_6913596_4 PFAM Lon protease (S16) C-terminal proteolytic domain K06870 - - 0.0000000000000000000000002785 116.0
HKD3_k127_6913596_5 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000007153 94.0
HKD3_k127_6913596_6 Dodecin K09165 - - 0.000000000000002187 78.0
HKD3_k127_6913596_7 Periplasmic copper-binding protein (NosD) - - - 0.000000000000003255 86.0
HKD3_k127_6961956_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 6.62e-238 747.0
HKD3_k127_6961956_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 535.0
HKD3_k127_6961956_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000003432 164.0
HKD3_k127_6961956_11 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000000866 146.0
HKD3_k127_6961956_12 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000001228 119.0
HKD3_k127_6961956_13 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000001502 99.0
HKD3_k127_6961956_14 Universal stress protein - - - 0.00000000000000000002544 96.0
HKD3_k127_6961956_15 Protein of unknown function (DUF2953) - - - 0.000000000000000007528 91.0
HKD3_k127_6961956_16 chorismate mutase K04093 - 5.4.99.5 0.00000000000000001587 86.0
HKD3_k127_6961956_17 Glyco_18 K01183 - 3.2.1.14 0.000000000000002421 90.0
HKD3_k127_6961956_2 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 529.0
HKD3_k127_6961956_3 PFAM peptidase M42 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 435.0
HKD3_k127_6961956_4 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 337.0
HKD3_k127_6961956_5 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 312.0
HKD3_k127_6961956_6 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 311.0
HKD3_k127_6961956_7 shikimate kinase activity K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 311.0
HKD3_k127_6961956_8 Lycopene cyclase protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 310.0
HKD3_k127_6961956_9 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000001398 168.0
HKD3_k127_6968430_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000009163 196.0
HKD3_k127_6968430_1 Pentapeptide repeats (9 copies) - - - 0.0000000008378 71.0
HKD3_k127_6982324_0 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 322.0
HKD3_k127_6982324_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000004916 234.0
HKD3_k127_6982324_2 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000009853 236.0
HKD3_k127_6982324_3 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000005978 145.0
HKD3_k127_6982324_4 Universal stress protein family - - - 0.000000000000000000000000000000003781 133.0
HKD3_k127_6982324_5 PFAM CBS domain containing protein - - - 0.00000000000000000000000000003598 121.0
HKD3_k127_712893_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1119.0
HKD3_k127_712893_1 repeat protein - - - 0.00000000000000000000001191 106.0
HKD3_k127_7137784_0 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 407.0
HKD3_k127_7137784_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 351.0
HKD3_k127_7137784_2 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 349.0
HKD3_k127_7137784_3 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 334.0
HKD3_k127_7137784_4 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 316.0
HKD3_k127_7137784_5 Serine protease with a broad substrate specificity K13276,K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002294 273.0
HKD3_k127_7137784_6 PFAM Class II Aldolase K01628 - 4.1.2.17 0.00000000000000000000000000000000000000001514 159.0
HKD3_k127_7137784_7 PFAM periplasmic copper-binding - - - 0.000000000000000000000000000000000174 149.0
HKD3_k127_7137784_8 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000009364 132.0
HKD3_k127_7137784_9 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000001965 121.0
HKD3_k127_7224631_0 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 351.0
HKD3_k127_7224631_1 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 281.0
HKD3_k127_7224631_2 PFAM PEBP family protein K06910 - - 0.0000000000000000000000000000000000000000000002489 175.0
HKD3_k127_7224631_3 PFAM Secreted repeat of - - - 0.00000000000000000000000001317 114.0
HKD3_k127_7224631_4 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000002176 106.0
HKD3_k127_7234366_0 - - - - 0.00000000000009661 76.0
HKD3_k127_727_0 TIGRFAM alpha-glucan - - - 9.492e-276 872.0
HKD3_k127_727_1 - - - - 0.000000000000000002809 87.0
HKD3_k127_727_2 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000005054 86.0
HKD3_k127_727_3 Belongs to the 'phage' integrase family K04763 - - 0.0000000113 59.0
HKD3_k127_727_4 Acid phosphatase homologues K19302 - 3.6.1.27 0.00007403 48.0
HKD3_k127_727_5 acyl-phosphate glycerol-3-phosphate acyltransferase activity K08591 - 2.3.1.15 0.0001843 52.0
HKD3_k127_7274361_0 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - - - 0.0000000000000000000000000000000000000000000000000000308 191.0
HKD3_k127_7274361_1 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000002566 186.0
HKD3_k127_7274361_2 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000001418 102.0
HKD3_k127_7274361_3 TIGRFAM drug resistance transporter, Bcr CflA subfamily K07552 - - 0.0001689 46.0
HKD3_k127_7286351_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005451 341.0
HKD3_k127_7286351_1 pyrroloquinoline quinone binding - - - 0.000000000000001505 90.0
HKD3_k127_72889_0 Aldo/keto reductase family K07079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 519.0
HKD3_k127_72889_1 Universal stress protein family - - - 0.00000000000000000000000001089 115.0
HKD3_k127_73403_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.649e-199 631.0
HKD3_k127_73403_1 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009626 235.0
HKD3_k127_73403_2 Recombinase - - - 0.000000000000000000000000000000000000000000000000000000434 202.0
HKD3_k127_73403_3 NnrU protein - - - 0.00000000000000000000000000000000000000000000008591 175.0
HKD3_k127_73403_4 Trypsin-like peptidase domain - - - 0.0000000000000000000005639 98.0
HKD3_k127_73403_5 - K01489 - 3.5.4.5 0.000000000000001142 80.0
HKD3_k127_7529162_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 391.0
HKD3_k127_7529162_1 - K00960 - 2.7.7.6 0.000000000000004083 76.0
HKD3_k127_7529186_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 392.0
HKD3_k127_7529186_1 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000192 75.0
HKD3_k127_7539260_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001411 263.0
HKD3_k127_7539260_1 membrane protein of uknown function UCP014873 - - - 0.00000000000000000004955 95.0
HKD3_k127_7539260_2 Domain of unknown function (DUF4277) - - - 0.0000001378 54.0
HKD3_k127_7544559_0 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000006016 184.0
HKD3_k127_7544559_1 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000000000000026 162.0
HKD3_k127_7544559_2 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000281 149.0
HKD3_k127_7544559_3 COG1654 Biotin operon repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000001733 138.0
HKD3_k127_7544559_4 Domain of unknown function (DUF4352) - - - 0.0000000000004622 75.0
HKD3_k127_7544559_5 metal-dependent phosphoesterases (PHP family) - - - 0.000001623 52.0
HKD3_k127_7596893_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.724e-317 990.0
HKD3_k127_7596893_1 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000003722 130.0
HKD3_k127_7596893_2 protein N-acetylglucosaminyltransferase activity K12600 - - 0.000000000000000000000000007075 114.0
HKD3_k127_7596893_3 tetratricopeptide repeat - - - 0.00000000000000000000002608 105.0
HKD3_k127_7598183_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 458.0
HKD3_k127_7598183_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001311 87.0
HKD3_k127_7598183_2 Glycosyl transferase family 21 - - - 0.000000000000007458 81.0
HKD3_k127_7598183_3 - - - - 0.000000000001261 72.0
HKD3_k127_7598183_4 Glycogen debranching enzyme - - - 0.0000004719 53.0
HKD3_k127_7599410_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 2.112e-198 628.0
HKD3_k127_7599410_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 445.0
HKD3_k127_7599410_10 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000002753 211.0
HKD3_k127_7599410_11 Subtilase family K17734 - - 0.0000000000000000000000000000000000000000000000000000000124 227.0
HKD3_k127_7599410_12 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001423 205.0
HKD3_k127_7599410_13 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000003035 191.0
HKD3_k127_7599410_14 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000016 179.0
HKD3_k127_7599410_15 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000000000000000000000000000002387 174.0
HKD3_k127_7599410_16 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000008802 160.0
HKD3_k127_7599410_17 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000002313 137.0
HKD3_k127_7599410_18 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000002676 131.0
HKD3_k127_7599410_19 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000008758 121.0
HKD3_k127_7599410_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 438.0
HKD3_k127_7599410_20 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000005289 111.0
HKD3_k127_7599410_21 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000005302 106.0
HKD3_k127_7599410_22 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000001465 96.0
HKD3_k127_7599410_23 PFAM PRC-barrel domain - - - 0.00000000000000000004769 92.0
HKD3_k127_7599410_24 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000007439 73.0
HKD3_k127_7599410_25 F420H2 dehydrogenase subunit FpoO K22170 - 1.5.98.3 0.0000197 50.0
HKD3_k127_7599410_26 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.00001992 49.0
HKD3_k127_7599410_3 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 425.0
HKD3_k127_7599410_4 C-terminal region of MMR_HSR1 domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 421.0
HKD3_k127_7599410_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 406.0
HKD3_k127_7599410_6 phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 394.0
HKD3_k127_7599410_7 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000002426 246.0
HKD3_k127_7599410_8 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000002077 225.0
HKD3_k127_7599410_9 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000001019 207.0
HKD3_k127_7616307_0 Belongs to the AAA ATPase family K07392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 396.0
HKD3_k127_7616307_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001377 275.0
HKD3_k127_7616307_2 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000003175 265.0
HKD3_k127_7616307_3 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000085 208.0
HKD3_k127_7616307_4 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000000000000000000000000000000000001297 186.0
HKD3_k127_7616307_5 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000004749 154.0
HKD3_k127_7616601_0 Hemerythrin HHE cation binding K07322 - - 0.000000000000000000000000000000000000000000000000001415 188.0
HKD3_k127_7616601_1 LysM domain - - - 0.00000000000000000000000000000000000000000000001313 179.0
HKD3_k127_7616601_2 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000052 118.0
HKD3_k127_7620389_0 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 429.0
HKD3_k127_7620389_1 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 339.0
HKD3_k127_7620389_10 DNA photolyase K01669 - 4.1.99.3 0.0000000004143 63.0
HKD3_k127_7620389_11 Deoxyribodipyrimidine photo-lyase activity. It is involved in the biological process described with DNA repair K01669 GO:0000719,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 4.1.99.3 0.0000008472 51.0
HKD3_k127_7620389_12 META domain - - - 0.000001383 55.0
HKD3_k127_7620389_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0004845 45.0
HKD3_k127_7620389_14 VIT family - - - 0.0007093 49.0
HKD3_k127_7620389_2 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000001576 201.0
HKD3_k127_7620389_3 COGs COG3415 Transposase and inactivated derivatives K07499 - - 0.00000000000000000000000000000000000001638 148.0
HKD3_k127_7620389_4 DNA photolyase K01669 - 4.1.99.3 0.0000000000000000000000000000000001455 138.0
HKD3_k127_7620389_5 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000002887 138.0
HKD3_k127_7620389_6 NnrU protein K21310 - 2.1.1.334 0.00000000000000000004431 94.0
HKD3_k127_7620389_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000004562 88.0
HKD3_k127_7620389_8 Cupin domain - - - 0.00000000000002464 77.0
HKD3_k127_7620389_9 NnrU protein K21310 - 2.1.1.334 0.0000000002302 63.0
HKD3_k127_7729011_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005209 515.0
HKD3_k127_7729011_1 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.00000000000000000000000002656 112.0
HKD3_k127_7729011_2 - - - - 0.0000000000000000005736 89.0
HKD3_k127_7729011_3 - K01489 - 3.5.4.5 0.000000000000000834 81.0
HKD3_k127_7729011_4 UPF0391 membrane protein - - - 0.00000003969 56.0
HKD3_k127_7729011_5 Phospholipid methyltransferase - - - 0.000001689 53.0
HKD3_k127_7729011_6 Stigma-specific protein, Stig1 - GO:0000003,GO:0003006,GO:0005575,GO:0005576,GO:0007275,GO:0008150,GO:0009790,GO:0009791,GO:0009793,GO:0010154,GO:0022414,GO:0032501,GO:0032502,GO:0042335,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458 - 0.000004807 51.0
HKD3_k127_773842_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 3.528e-275 864.0
HKD3_k127_773842_1 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007724 531.0
HKD3_k127_773842_2 PFAM CBS domain containing protein - - - 0.0000000000000000004082 93.0
HKD3_k127_7749213_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 440.0
HKD3_k127_7749213_1 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000009157 167.0
HKD3_k127_7749213_2 PFAM Tetratricopeptide repeat - - - 0.0000000000000001633 85.0
HKD3_k127_7749213_3 DNA polymerase activity K02319 - 2.7.7.7 0.000000000000001526 83.0
HKD3_k127_7749213_4 DNA-binding transcription factor activity - - - 0.00000000004248 67.0
HKD3_k127_7797667_0 DEAD/H associated K03724 - - 0.0 1111.0
HKD3_k127_7797667_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.76e-225 712.0
HKD3_k127_7797667_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 494.0
HKD3_k127_7797667_3 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 377.0
HKD3_k127_7797667_4 PFAM Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001044 273.0
HKD3_k127_7797667_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000003555 147.0
HKD3_k127_7797667_6 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000006383 113.0
HKD3_k127_7797667_7 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K02030 - - 0.0000004257 52.0
HKD3_k127_7893832_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 574.0
HKD3_k127_7893832_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000004412 79.0
HKD3_k127_7893832_2 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.00000000000003974 73.0
HKD3_k127_7893832_3 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000008834 50.0
HKD3_k127_7918833_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 364.0
HKD3_k127_7918833_1 ABC-type metal ion transport system periplasmic component surface adhesin K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004359 258.0
HKD3_k127_7918833_2 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000002058 242.0
HKD3_k127_7918833_3 CAAX protease self-immunity K07052 - - 0.0000000000000000123 87.0
HKD3_k127_7918833_4 - - - - 0.000000000000000472 83.0
HKD3_k127_7918833_5 SPFH Band 7 PHB domain protein - - - 0.0000000000000007242 87.0
HKD3_k127_7918833_6 Putative zinc ribbon domain - - - 0.0000000000000009189 80.0
HKD3_k127_7918833_7 CAAX protease self-immunity K07052 - - 0.00002568 49.0
HKD3_k127_8026578_0 Heat shock 70 kDa protein K04043 - - 1.818e-258 809.0
HKD3_k127_8026578_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 578.0
HKD3_k127_8026578_10 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000942 162.0
HKD3_k127_8026578_11 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000366 126.0
HKD3_k127_8026578_12 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000004797 126.0
HKD3_k127_8026578_13 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.0000000000000000000107 97.0
HKD3_k127_8026578_14 transposase activity K07481 - - 0.0004742 44.0
HKD3_k127_8026578_2 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 411.0
HKD3_k127_8026578_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 414.0
HKD3_k127_8026578_4 PFAM glutamate--cysteine ligase, GCS2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 398.0
HKD3_k127_8026578_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 370.0
HKD3_k127_8026578_6 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000002421 221.0
HKD3_k127_8026578_7 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000002797 200.0
HKD3_k127_8026578_8 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000003292 172.0
HKD3_k127_8026578_9 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000003506 167.0
HKD3_k127_8065603_0 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009217 344.0
HKD3_k127_8065603_1 glyoxalase K04750 - - 0.00000000000000000000000000000000000000000000000001684 185.0
HKD3_k127_8065603_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000003438 173.0
HKD3_k127_8065603_3 Permease - - - 0.00000000000000000000000000000000000000001242 168.0
HKD3_k127_8065603_4 OsmC-like protein K07397 - - 0.00000000000000000002545 95.0
HKD3_k127_8065603_5 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000004784 92.0
HKD3_k127_8065603_6 Protein of unknown function (DUF4064) - - - 0.0000000004152 66.0
HKD3_k127_8065603_7 Amino acid permease K03294 - - 0.000000000955 61.0
HKD3_k127_8065603_8 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000009259 56.0
HKD3_k127_8165758_0 PFAM ferredoxin-dependent glutamate synthase - - - 1.032e-297 919.0
HKD3_k127_8165758_1 HMGL-like K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 575.0
HKD3_k127_8165758_2 sugar phosphatases of the HAD superfamily K01101,K02566 - 3.1.3.41 0.000000000000000000000000000000000000000000000000005427 186.0
HKD3_k127_8165758_3 sugar phosphatases of the HAD superfamily K02566 - - 0.0000003975 53.0
HKD3_k127_8165758_4 Periplasmic copper-binding protein (NosD) - - - 0.00004913 47.0
HKD3_k127_8180701_0 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000003566 213.0
HKD3_k127_8180701_1 YEATS family - - - 0.00006128 52.0
HKD3_k127_8193846_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1201.0
HKD3_k127_8193846_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 9.147e-213 681.0
HKD3_k127_8193846_10 Transglutaminase-like superfamily - - - 0.00000000006341 74.0
HKD3_k127_8193846_2 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 502.0
HKD3_k127_8193846_3 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 463.0
HKD3_k127_8193846_4 Clp protease K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 415.0
HKD3_k127_8193846_5 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 323.0
HKD3_k127_8193846_6 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 313.0
HKD3_k127_8193846_7 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000001177 132.0
HKD3_k127_8193846_8 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000006862 79.0
HKD3_k127_8193846_9 Transposase and inactivated derivatives K07494 - - 0.000000000000002244 79.0
HKD3_k127_8195118_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 1.024e-264 829.0
HKD3_k127_8195118_1 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 1.216e-201 637.0
HKD3_k127_8195118_10 - - - - 0.000000000000003134 85.0
HKD3_k127_8195118_11 Chagasin family peptidase inhibitor I42 K14475 - - 0.0004218 51.0
HKD3_k127_8195118_2 ferredoxin oxidoreductase K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 510.0
HKD3_k127_8195118_3 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 412.0
HKD3_k127_8195118_4 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 371.0
HKD3_k127_8195118_5 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000165 277.0
HKD3_k127_8195118_6 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000007909 225.0
HKD3_k127_8195118_7 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000001298 182.0
HKD3_k127_8195118_8 stage II sporulation K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000008453 179.0
HKD3_k127_8195118_9 Hemerythrin HHE cation binding K07322 - - 0.0000000000000000000001463 100.0
HKD3_k127_822295_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 539.0
HKD3_k127_822295_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006003 522.0
HKD3_k127_822295_10 - - - - 0.0000000000000001468 85.0
HKD3_k127_822295_11 - - - - 0.000000000000002582 82.0
HKD3_k127_822295_12 Alanine dehydrogenase/PNT, C-terminal domain K13979 GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 - 0.00000000000001951 81.0
HKD3_k127_822295_13 PKD domain - - - 0.00002661 57.0
HKD3_k127_822295_14 - - - - 0.0009923 43.0
HKD3_k127_822295_2 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 458.0
HKD3_k127_822295_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 369.0
HKD3_k127_822295_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 297.0
HKD3_k127_822295_5 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001401 275.0
HKD3_k127_822295_6 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002271 229.0
HKD3_k127_822295_7 alcohol dehydrogenase K13979 - - 0.0000000000000000000000000000000000000001718 158.0
HKD3_k127_822295_8 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000002257 143.0
HKD3_k127_822295_9 Alcohol dehydrogenase GroES-like domain K00083 GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009698,GO:0009699,GO:0009808,GO:0009809,GO:0009987,GO:0019438,GO:0019748,GO:0044237,GO:0044249,GO:0044550,GO:0071704,GO:1901360,GO:1901362,GO:1901576 1.1.1.195 0.0000000000000000000000000006275 117.0
HKD3_k127_8291263_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 522.0
HKD3_k127_8291263_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009736 348.0
HKD3_k127_8291263_10 Antibiotic biosynthesis monooxygenase - - - 0.000000002365 61.0
HKD3_k127_8291263_11 Potassium channel K05389 GO:0000325,GO:0003674,GO:0003824,GO:0004788,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0005886,GO:0005887,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006996,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009108,GO:0009229,GO:0009314,GO:0009416,GO:0009507,GO:0009532,GO:0009533,GO:0009534,GO:0009536,GO:0009570,GO:0009579,GO:0009628,GO:0009657,GO:0009668,GO:0009705,GO:0009987,GO:0010027,GO:0010196,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0016740,GO:0016772,GO:0016778,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0030322,GO:0031090,GO:0031224,GO:0031226,GO:0031976,GO:0031984,GO:0034220,GO:0034641,GO:0042357,GO:0042391,GO:0042723,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0046483,GO:0046873,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0061024,GO:0065003,GO:0065007,GO:0065008,GO:0071704,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098805,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1990066 - 0.0001222 46.0
HKD3_k127_8291263_2 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000013 288.0
HKD3_k127_8291263_3 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000406 252.0
HKD3_k127_8291263_4 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000004718 225.0
HKD3_k127_8291263_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000001415 199.0
HKD3_k127_8291263_6 transposition, DNA-mediated - - - 0.0000000000000000000000000000000000002261 145.0
HKD3_k127_8291263_7 CHASE - - - 0.00000000000000000000000001879 113.0
HKD3_k127_8291263_8 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. K19519 - - 0.00000000000000000003525 102.0
HKD3_k127_8291263_9 PFAM CBS domain containing protein - - - 0.000000000000001567 79.0
HKD3_k127_8302046_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 535.0
HKD3_k127_8302046_1 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 344.0
HKD3_k127_8302046_2 PFAM glutamate synthase alpha subunit K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000001484 234.0
HKD3_k127_8302046_3 Involved in cell shape control K22222 - - 0.0000000000000000000000000000000002855 136.0
HKD3_k127_8302046_4 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000006959 117.0
HKD3_k127_8466484_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 584.0
HKD3_k127_8466484_1 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 458.0
HKD3_k127_8466484_10 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000006428 108.0
HKD3_k127_8466484_11 B-block binding subunit of TFIIIC - - - 0.000000000000000000000003352 106.0
HKD3_k127_8466484_12 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000006441 101.0
HKD3_k127_8466484_13 PFAM nitrogen-fixing NifU - - - 0.00000000000000000001208 93.0
HKD3_k127_8466484_14 - - - - 0.0000000000004392 73.0
HKD3_k127_8466484_15 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.000002452 51.0
HKD3_k127_8466484_2 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 398.0
HKD3_k127_8466484_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 344.0
HKD3_k127_8466484_4 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 331.0
HKD3_k127_8466484_5 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000000323 198.0
HKD3_k127_8466484_6 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000008141 187.0
HKD3_k127_8466484_7 Putative Fe-S cluster K11260 - - 0.00000000000000000000000000000000000000000000000002327 183.0
HKD3_k127_8466484_8 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000007419 181.0
HKD3_k127_8466484_9 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000000000000000001644 161.0
HKD3_k127_8550575_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 571.0
HKD3_k127_8550575_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 409.0
HKD3_k127_8550575_2 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000002807 236.0
HKD3_k127_8550575_3 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000156 162.0
HKD3_k127_8550575_4 Large family of predicted nucleotide-binding domains K07158 - - 0.00000000000000000000000000118 116.0
HKD3_k127_8550575_5 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000608 91.0
HKD3_k127_8550575_6 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000004077 78.0
HKD3_k127_8582473_0 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 366.0
HKD3_k127_8582473_1 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 330.0
HKD3_k127_8582473_2 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000001016 146.0
HKD3_k127_8582473_3 - - - - 0.00000000000000000000004074 100.0
HKD3_k127_8582473_4 NAD(P)H dehydrogenase (quinone) K00355 - 1.6.5.2 0.000000000000000001677 87.0
HKD3_k127_8582473_5 Domain of unknown function (DUF4215) - - - 0.0003116 44.0
HKD3_k127_8582473_6 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0007442 43.0
HKD3_k127_8610589_0 PFAM Acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 357.0
HKD3_k127_8610589_1 PFAM Acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003612 265.0
HKD3_k127_8610589_2 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000001952 249.0
HKD3_k127_8618644_0 KH, type 1, domain K07041 - - 2.299e-311 963.0
HKD3_k127_8618644_1 DEAD DEAH box helicase domain protein K03725 - - 1.457e-230 738.0
HKD3_k127_8618644_10 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000026 162.0
HKD3_k127_8618644_11 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.00000006674 57.0
HKD3_k127_8618644_12 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00007233 49.0
HKD3_k127_8618644_2 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.544e-220 693.0
HKD3_k127_8618644_3 PFAM PilT protein domain protein K06865 - - 6.444e-213 677.0
HKD3_k127_8618644_4 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 348.0
HKD3_k127_8618644_5 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 329.0
HKD3_k127_8618644_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 261.0
HKD3_k127_8618644_7 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000005085 214.0
HKD3_k127_8618644_8 ArsR transcriptional regulator - - - 0.000000000000000000000000000000000000000000000002047 178.0
HKD3_k127_8618644_9 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000001677 171.0
HKD3_k127_8635160_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 4.119e-237 760.0
HKD3_k127_8635160_1 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 356.0
HKD3_k127_8635160_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 321.0
HKD3_k127_8635160_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000002087 150.0
HKD3_k127_8635160_4 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000000003688 124.0
HKD3_k127_8635160_5 TPR repeat-containing protein - - - 0.0000000000000000006225 93.0
HKD3_k127_8635160_6 Lrp/AsnC ligand binding domain - - - 0.00000000000002089 76.0
HKD3_k127_8667133_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1293.0
HKD3_k127_8667133_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 8.522e-302 934.0
HKD3_k127_8667133_10 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.000000000000000000000000001806 114.0
HKD3_k127_8667133_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 493.0
HKD3_k127_8667133_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 458.0
HKD3_k127_8667133_4 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 398.0
HKD3_k127_8667133_5 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000001769 243.0
HKD3_k127_8667133_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000008475 235.0
HKD3_k127_8667133_7 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000886 220.0
HKD3_k127_8667133_8 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000005289 192.0
HKD3_k127_8667133_9 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000003163 142.0
HKD3_k127_8684518_0 zinc metalloprotease whose natural substrate is K06974 GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000002805 178.0
HKD3_k127_8684518_1 PHP-associated - - - 0.000000000000007283 79.0
HKD3_k127_8684518_2 - - - - 0.000000002553 64.0
HKD3_k127_8684518_3 DNA polymerase alpha chain like domain - - - 0.0000002538 57.0
HKD3_k127_8684518_4 sporulation integral membrane protein YtvI - - - 0.0000004144 53.0
HKD3_k127_8763863_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 498.0
HKD3_k127_8763863_1 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 484.0
HKD3_k127_8763863_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009942 426.0
HKD3_k127_8763863_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 378.0
HKD3_k127_8763863_4 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 308.0
HKD3_k127_8763863_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004316 289.0
HKD3_k127_8763863_6 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441 - 1.12.98.1 0.0000000000000005025 81.0
HKD3_k127_8763863_7 Protein of unknown function (DUF1638) - - - 0.0002416 44.0
HKD3_k127_8786343_0 PFAM Pyridoxal-dependent decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 379.0
HKD3_k127_8786343_1 SCO1/SenC - - - 0.000000000000000000000000000000000000000000000000000000000003798 211.0
HKD3_k127_8786343_2 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000001919 121.0
HKD3_k127_8786343_3 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000000000000004507 119.0
HKD3_k127_8786343_4 PFAM transposase, IS4 family protein - - - 0.000000000003019 67.0
HKD3_k127_8817443_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 593.0
HKD3_k127_8817443_1 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 508.0
HKD3_k127_8817443_10 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000000000002091 142.0
HKD3_k127_8817443_11 AMP binding - - - 0.0000000000000000000001708 107.0
HKD3_k127_8817443_12 Na+/H+ ion antiporter subunit K05569 - - 0.00000000000000008395 81.0
HKD3_k127_8817443_13 Domain of unknown function (DUF4040) K05566 - - 0.0000000000000001945 82.0
HKD3_k127_8817443_14 TIGRFAM TIGR00304 family protein - - - 0.0000008539 55.0
HKD3_k127_8817443_15 - - - - 0.000007137 53.0
HKD3_k127_8817443_2 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 478.0
HKD3_k127_8817443_3 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 476.0
HKD3_k127_8817443_4 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000001398 220.0
HKD3_k127_8817443_5 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000008966 223.0
HKD3_k127_8817443_6 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000005095 172.0
HKD3_k127_8817443_7 Domain of unknown function (DUF4040) K05566 - - 0.0000000000000000000000000000000000000000001862 167.0
HKD3_k127_8817443_8 - - - - 0.000000000000000000000000000000000000001826 154.0
HKD3_k127_8817443_9 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.000000000000000000000000000000000001694 145.0
HKD3_k127_8895710_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 413.0
HKD3_k127_8938891_0 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000003776 211.0
HKD3_k127_8938891_1 radical SAM domain protein - - - 0.0000000000000000000000000000002084 131.0
HKD3_k127_901823_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000001996 141.0
HKD3_k127_901823_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000199 130.0
HKD3_k127_9058792_0 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000005189 98.0
HKD3_k127_9058792_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000001338 83.0
HKD3_k127_9058792_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000001227 68.0
HKD3_k127_9058792_3 Belongs to the 'phage' integrase family K04763 - - 0.000000008477 64.0
HKD3_k127_9058792_4 Belongs to the 'phage' integrase family - - - 0.0000000197 57.0
HKD3_k127_9058802_0 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 421.0
HKD3_k127_9058802_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000001338 83.0
HKD3_k127_9061293_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 379.0
HKD3_k127_9061293_1 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 316.0
HKD3_k127_9061293_2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 293.0
HKD3_k127_9061293_3 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001054 238.0
HKD3_k127_9061293_4 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.0000000000000000000002097 102.0
HKD3_k127_9061293_5 Iron-sulphur cluster biosynthesis K15724 - - 0.00000000008379 67.0
HKD3_k127_9070568_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 318.0
HKD3_k127_9070568_1 Domain of Unknown Function (DUF1259) - - - 0.000000000000000000000000000000000000001138 153.0
HKD3_k127_9070568_2 SpoIIAA-like - - - 0.000000000001542 72.0
HKD3_k127_9070568_3 Conserved protein - - - 0.0000000000967 65.0
HKD3_k127_9070568_4 - - - - 0.00000005125 57.0
HKD3_k127_9070568_5 - - - - 0.000001727 54.0
HKD3_k127_9196530_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000002762 96.0
HKD3_k127_9196530_1 - - - - 0.00000000000002991 76.0
HKD3_k127_9196530_2 Transposase domain (DUF772) K07481 - - 0.0000005859 51.0
HKD3_k127_9208229_0 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 509.0
HKD3_k127_9208229_1 Cation transport regulator K06197 - - 0.00000000000000000000000000008275 116.0
HKD3_k127_9230915_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 527.0
HKD3_k127_9230915_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 373.0
HKD3_k127_9230915_2 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000001555 228.0
HKD3_k127_9230915_3 PBS lyase HEAT-like repeat - - - 0.0000000000000000114 94.0
HKD3_k127_9230915_4 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000332 70.0
HKD3_k127_9238261_0 - - - - 0.00000000000000000000000000000000000000000000000123 177.0
HKD3_k127_9238261_1 PFAM Mg2 transporter protein, CorA family protein K16074 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000145 69.0
HKD3_k127_9238261_2 - - - - 0.00000000004043 68.0
HKD3_k127_9238261_3 Sodium:dicarboxylate symporter family K03309 - - 0.00000006486 58.0
HKD3_k127_9329990_0 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 343.0
HKD3_k127_9329990_1 PFAM Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 301.0
HKD3_k127_9329990_2 glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000001934 189.0
HKD3_k127_9389524_0 LOR SDH bifunctional protein conserved domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 507.0
HKD3_k127_9389524_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 419.0
HKD3_k127_9389524_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 280.0
HKD3_k127_9389524_3 RNA ligase K07468 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003163 260.0
HKD3_k127_9537354_0 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000001257 179.0
HKD3_k127_9537354_1 Domain of unknown function DUF123 - - - 0.0000000000000000000000000000000007108 136.0
HKD3_k127_9537354_2 Domain of unknown function DUF11 - - - 0.00000000003157 78.0
HKD3_k127_9543738_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 542.0
HKD3_k127_9543738_1 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000003212 216.0
HKD3_k127_9543738_2 PFAM Adenylate cyclase K05873 GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849 4.6.1.1 0.000000000000000000000000000000001948 138.0
HKD3_k127_9634396_0 PFAM Glycosyl transferase, family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 4.546e-213 674.0
HKD3_k127_9651176_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000004767 239.0
HKD3_k127_9651176_1 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000001129 216.0
HKD3_k127_9651176_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000004554 190.0
HKD3_k127_9651176_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000002872 146.0
HKD3_k127_9651176_4 Belongs to the 'phage' integrase family - - - 0.00000731 51.0
HKD3_k127_9651176_5 Belongs to the 'phage' integrase family K04763 - - 0.00003042 50.0
HKD3_k127_96815_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000003006 172.0
HKD3_k127_96815_1 - - - - 0.0000000000000000000000000001578 117.0
HKD3_k127_96815_2 COGs COG3415 Transposase and inactivated derivatives K07499 - - 0.0000000000000000000000006435 106.0
HKD3_k127_96815_3 - - - - 0.000000000000000000000794 99.0
HKD3_k127_96815_4 Transposase and inactivated derivatives K07494 - - 0.000000000000000006146 85.0
HKD3_k127_96815_5 PFAM glutamate synthase alpha subunit domain protein K00202 GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 0.0000000008599 68.0
HKD3_k127_96815_6 oxidoreductase activity - - - 0.000000005958 68.0
HKD3_k127_96815_7 associated with various cellular activities K03924 - - 0.00001306 57.0
HKD3_k127_974269_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 3.138e-265 820.0
HKD3_k127_974269_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007995 576.0
HKD3_k127_974269_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 359.0
HKD3_k127_974269_3 PFAM Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000005078 228.0
HKD3_k127_974269_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000008468 117.0
HKD3_k127_974269_5 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.0000000000000004065 83.0
HKD3_k127_974269_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000007426 77.0