logo

Overview

ID MAG01838
Name HKD3_bin.16
Sample SMP0048
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanosarcinales
Family Methanoperedenaceae
Genus Methanoperedens
Species
Assembly information
Completeness (%) 78.89
Contamination (%) 3.64
GC content (%) 44.0
N50 (bp) 6,117
Genome size (bp) 2,158,596

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2228

Gene name Description KEGG GOs EC E-value Score Sequence
HKD3_k127_1002483_0 ABC transporter K01990,K09691,K09693 - 3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 421.0
HKD3_k127_1002483_1 Glycosyl transferase, family 2 K00721,K07011,K20444 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 340.0
HKD3_k127_1002483_2 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000249 265.0
HKD3_k127_1002483_3 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000002072 150.0
HKD3_k127_1002483_4 transferase activity, transferring glycosyl groups K12995 - 2.4.1.348 0.00000000000000003617 94.0
HKD3_k127_1002483_5 Methyltransferase domain - - - 0.000000002595 70.0
HKD3_k127_1027340_0 Patched family K07003 - - 0.0000000000000000000000000000000000000000000000008654 189.0
HKD3_k127_1027340_1 transcriptional - - - 0.000000000000000000000000000000000001187 149.0
HKD3_k127_1027340_2 Patched family K07003 - - 0.0000000000000000000000000000000008612 144.0
HKD3_k127_1052853_0 TIGRFAM UbiD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 454.0
HKD3_k127_1052853_1 - - - - 0.00000000000000000000000000000001975 136.0
HKD3_k127_1057800_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.206e-243 769.0
HKD3_k127_1057800_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007959 300.0
HKD3_k127_1057800_2 Domain of unknown function (DUF4258) - - - 0.0000000000000000000000000000000000000000000319 162.0
HKD3_k127_1057800_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000004277 164.0
HKD3_k127_1057800_4 - - - - 0.00000000000000000000000000000000001096 137.0
HKD3_k127_1057800_5 N-4 methylation of cytosine - - - 0.00000000000000000000000004793 108.0
HKD3_k127_107541_0 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 336.0
HKD3_k127_107541_1 PFAM transposase IS116 IS110 IS902 family protein - - - 0.000000000000000000000000000000000000000000002613 171.0
HKD3_k127_107541_3 PFAM transposase IS116 IS110 IS902 family - - - 0.00000000000751 70.0
HKD3_k127_107541_4 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.00004076 56.0
HKD3_k127_1139308_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 401.0
HKD3_k127_1139308_1 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 379.0
HKD3_k127_1139308_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002658 242.0
HKD3_k127_1139308_3 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000000000000000000000000007875 172.0
HKD3_k127_1139308_4 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - 0.0000000000000000000000000000000000000004005 151.0
HKD3_k127_1139308_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000004339 109.0
HKD3_k127_1139308_6 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00002199 52.0
HKD3_k127_117680_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002251 278.0
HKD3_k127_117680_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins K01179 - 3.2.1.4 0.000000000000000000006943 109.0
HKD3_k127_117680_2 domain protein K01179,K01342,K01406,K07004,K12287,K14194,K15125,K20276 - 3.2.1.4,3.4.21.62,3.4.24.40 0.00000001952 68.0
HKD3_k127_117680_3 - - - - 0.0000323 54.0
HKD3_k127_11826_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 456.0
HKD3_k127_11826_1 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000486 171.0
HKD3_k127_11826_3 4Fe-4S dicluster domain - - - 0.000000000003247 70.0
HKD3_k127_11826_4 Transcriptional regulator - - - 0.000000184 56.0
HKD3_k127_1200521_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1083.0
HKD3_k127_1200521_1 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 3.752e-247 772.0
HKD3_k127_1200521_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 599.0
HKD3_k127_1200521_3 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 471.0
HKD3_k127_1200521_4 COG0863 DNA modification methylase K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 411.0
HKD3_k127_1200521_5 ATPase, P-type transporting, HAD superfamily, subfamily IC K01531,K01535 - 3.6.3.2,3.6.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 379.0
HKD3_k127_1200521_6 shikimate kinase activity K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 328.0
HKD3_k127_1200521_7 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 286.0
HKD3_k127_1200521_8 chorismate mutase K04093 - 5.4.99.5 0.0000000000000000000000008436 106.0
HKD3_k127_1201576_0 Phosphate uptake regulator, PhoU - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006637 252.0
HKD3_k127_1201576_1 - - - - 0.000000000000000004353 98.0
HKD3_k127_1201576_2 PBP superfamily domain K02040 - - 0.0000001276 60.0
HKD3_k127_1211810_0 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 413.0
HKD3_k127_1211810_1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 299.0
HKD3_k127_1211810_2 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006695 276.0
HKD3_k127_1211810_3 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000001518 204.0
HKD3_k127_1211810_4 PFAM peptidase - - - 0.00000000000000000000000000000000000002225 152.0
HKD3_k127_1211810_5 PFAM ABC transporter related K01990 - - 0.00000000000000005834 83.0
HKD3_k127_1266152_0 Type II/IV secretion system protein - - - 4.202e-222 712.0
HKD3_k127_1266152_1 - - - - 4.387e-222 706.0
HKD3_k127_1266152_2 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006756 277.0
HKD3_k127_1266152_3 PFAM Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000003498 182.0
HKD3_k127_1266152_4 - - - - 0.00000000000000000000001279 107.0
HKD3_k127_1266152_5 ubiE/COQ5 methyltransferase family - - - 0.00000000000000001387 92.0
HKD3_k127_1266152_6 - K07333 - - 0.000000000478 66.0
HKD3_k127_1266152_7 Putative antitoxin - - - 0.0000026 52.0
HKD3_k127_1298476_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 2.687e-209 662.0
HKD3_k127_1298476_1 PFAM glutamate synthase alpha subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 318.0
HKD3_k127_1298476_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000003011 220.0
HKD3_k127_1306623_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000002632 178.0
HKD3_k127_1306623_1 S-layer protein - - - 0.00000000000002247 87.0
HKD3_k127_1308312_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 4.51e-266 829.0
HKD3_k127_1308312_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 2.339e-229 718.0
HKD3_k127_1308312_2 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 559.0
HKD3_k127_1308312_3 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 524.0
HKD3_k127_1308312_4 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 325.0
HKD3_k127_1308312_5 Polyprenyl synthetase K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000003133 243.0
HKD3_k127_1308312_6 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000007206 187.0
HKD3_k127_1308312_7 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000000005384 120.0
HKD3_k127_1308312_8 mRNA binding - - - 0.00000000000000000000000204 104.0
HKD3_k127_1308312_9 Protein of unknown function (DUF1699) - - - 0.00000000000000000000003289 102.0
HKD3_k127_1325514_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 1.245e-256 803.0
HKD3_k127_1325514_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 340.0
HKD3_k127_1325514_2 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000005131 256.0
HKD3_k127_1325514_3 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00580 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000001052 252.0
HKD3_k127_1325514_4 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00579 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000004924 251.0
HKD3_k127_1325514_5 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000001315 150.0
HKD3_k127_1325514_6 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00578 - 2.1.1.86 0.00000000000000000000000001189 113.0
HKD3_k127_1360423_0 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 412.0
HKD3_k127_1389572_0 Belongs to the RtcB family K14415 - 6.5.1.3 8.561e-229 717.0
HKD3_k127_1389572_1 PINc domain ribonuclease K09006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 320.0
HKD3_k127_1389572_2 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01838 - 5.4.2.6 0.0000000000000000000000000000000000000000000000000000006385 196.0
HKD3_k127_1389572_3 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase K19302 - 3.6.1.27 0.0000000000000000000000000000128 130.0
HKD3_k127_1389572_4 peptidyl-tyrosine sulfation - - - 0.00000000000000000000008047 100.0
HKD3_k127_1389572_5 - - - - 0.000000000000000000002641 96.0
HKD3_k127_1389572_6 protein conserved in archaea - - - 0.00000000000000000004843 93.0
HKD3_k127_1389572_7 Family of unknown function (DUF5350) - - - 0.000000000000711 72.0
HKD3_k127_1389572_8 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01838 - 5.4.2.6 0.00000005937 54.0
HKD3_k127_1389740_0 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000338 258.0
HKD3_k127_1389740_1 TIGRFAM TIGR00268 family protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001293 250.0
HKD3_k127_1389740_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000000000000000000000000000000000000000000000000000000001519 232.0
HKD3_k127_1389740_3 - - - - 0.00000000000000000000000000000000000008605 147.0
HKD3_k127_1389740_4 PFAM DNA polymerase beta domain protein region K07076 - - 0.000000000000000000000000002753 117.0
HKD3_k127_1389740_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.000000000000000000000000004081 113.0
HKD3_k127_1389740_6 protein conserved in archaea - - - 0.0000000000000000000008577 100.0
HKD3_k127_1389740_7 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - 0.000000000000000000002106 107.0
HKD3_k127_1389740_8 HEPN domain - - - 0.0000000000000000004699 91.0
HKD3_k127_1389740_9 - - - - 0.00000000000007671 80.0
HKD3_k127_1396007_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 5.914e-301 934.0
HKD3_k127_1396007_1 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 519.0
HKD3_k127_1396007_2 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 366.0
HKD3_k127_1396007_3 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000002686 193.0
HKD3_k127_1396007_4 PFAM Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000001089 193.0
HKD3_k127_1396007_5 Domain of unknown function DUF128 K21640 - - 0.000000000000000000000000000000000000000000000001073 178.0
HKD3_k127_1396007_6 - - - - 0.0000000000000000000000000000000000000000001461 172.0
HKD3_k127_1396007_7 4Fe-4S dicluster domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000005939 135.0
HKD3_k127_139681_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 6.796e-208 654.0
HKD3_k127_139681_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 476.0
HKD3_k127_139681_10 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.000000000000000000000000007338 111.0
HKD3_k127_139681_11 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000004701 103.0
HKD3_k127_139681_12 PFAM Glutaredoxin K06191 - - 0.000000000000000000001015 96.0
HKD3_k127_139681_13 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.0000000000000000001819 89.0
HKD3_k127_139681_14 TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family K00171 - 1.2.7.1 0.00000000000000009472 91.0
HKD3_k127_139681_2 Pyruvate:ferredoxin oxidoreductase core domain II K00169 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 390.0
HKD3_k127_139681_3 PFAM Thiamine pyrophosphate K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 302.0
HKD3_k127_139681_4 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002412 280.0
HKD3_k127_139681_5 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007305 258.0
HKD3_k127_139681_6 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000156 254.0
HKD3_k127_139681_7 pyruvate synthase activity K00172,K00189 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000000000000003955 207.0
HKD3_k127_139681_8 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000004442 146.0
HKD3_k127_139681_9 phosphate ion binding K02040 - - 0.000000000000000000000000004891 118.0
HKD3_k127_1401073_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.445e-232 729.0
HKD3_k127_1401073_1 PFAM Aldehyde dehydrogenase K22187 - - 1.58e-206 650.0
HKD3_k127_1401073_2 PFAM O-methyltransferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000001161 219.0
HKD3_k127_1401073_3 Domain of unknown function (DUF4870) - - - 0.00000000000000000000000004391 111.0
HKD3_k127_1401073_4 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000001188 83.0
HKD3_k127_1401073_5 Transcription regulator K03718 - - 0.0000000000008929 75.0
HKD3_k127_1401073_6 TM2 domain - - - 0.0000000004006 64.0
HKD3_k127_1411599_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 2.027e-197 632.0
HKD3_k127_1411599_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000005577 196.0
HKD3_k127_1411599_2 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000002286 183.0
HKD3_k127_1411599_3 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000000000000000000000000000000000000000008927 177.0
HKD3_k127_1411599_4 Transcriptional regulator K07721 - - 0.0000000000000000000000000000000000004252 143.0
HKD3_k127_1411599_5 PFAM DNA polymerase, beta domain protein region K07076 - - 0.00000000000000000000000000003653 122.0
HKD3_k127_1411599_6 Belongs to the sulfur carrier protein TusA family - - - 0.000000000004243 68.0
HKD3_k127_1421059_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 478.0
HKD3_k127_1421059_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 378.0
HKD3_k127_1421059_3 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000001266 246.0
HKD3_k127_1421059_4 Urm1 (Ubiquitin related modifier) K03636 - - 0.00000000000000003831 84.0
HKD3_k127_1421059_5 SpoVT / AbrB like domain - - - 0.000003318 52.0
HKD3_k127_1425281_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1249.0
HKD3_k127_1425281_1 phosphoesterase RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 544.0
HKD3_k127_1425281_2 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 364.0
HKD3_k127_1425281_3 - - - - 0.00000000000000000000000000000000000000000000003062 182.0
HKD3_k127_1425281_4 - - - - 0.0000000000000000000002196 99.0
HKD3_k127_1444048_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.112e-203 646.0
HKD3_k127_1444048_1 Protein of unknown function (DUF460) K09150 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 591.0
HKD3_k127_1444048_2 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007497 327.0
HKD3_k127_1444048_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 338.0
HKD3_k127_1444048_4 - - - - 0.00000002047 56.0
HKD3_k127_1444048_5 toxin-antitoxin pair type II binding - - - 0.000001436 53.0
HKD3_k127_1451666_0 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 321.0
HKD3_k127_1451666_1 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000001392 234.0
HKD3_k127_1451666_2 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000001471 123.0
HKD3_k127_1451666_3 Domain of unknown function (DUF1805) - - - 0.00000000000000000000000002477 110.0
HKD3_k127_1451666_4 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000002383 108.0
HKD3_k127_1464417_0 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000005584 185.0
HKD3_k127_1464417_1 - - - - 0.00000000000000000000000005405 112.0
HKD3_k127_1464417_2 PFAM extracellular solute-binding protein family 1 K02040 - - 0.000000001226 70.0
HKD3_k127_1464417_3 Winged helix-turn-helix - - - 0.0000002819 55.0
HKD3_k127_1464417_4 ABC-type phosphate transport system periplasmic K02040 - - 0.000006375 54.0
HKD3_k127_1464417_5 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0001147 45.0
HKD3_k127_1475334_0 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 580.0
HKD3_k127_1475334_1 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000000000000002369 130.0
HKD3_k127_1475334_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000001028 98.0
HKD3_k127_1475334_3 but it may be involved in stabilization of the trimeric complex - - - 0.000000000007652 66.0
HKD3_k127_1475334_4 Domain of unknown function DUF11 K20276 - - 0.0001173 54.0
HKD3_k127_1516176_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 360.0
HKD3_k127_1516176_1 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002956 279.0
HKD3_k127_1516176_2 PhoU domain - - - 0.00000000000000000000000000000000000000000000000001107 192.0
HKD3_k127_1516176_3 - - - - 0.000000000000000000000000000003196 127.0
HKD3_k127_1516176_4 - - - - 0.0000000001614 62.0
HKD3_k127_1526055_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 567.0
HKD3_k127_1526055_1 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 487.0
HKD3_k127_1526055_2 cytochrome complex assembly - - - 0.0000000000000000000000000000000000000000000000000000000000000001798 232.0
HKD3_k127_1526055_3 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000000000000000000000000008324 206.0
HKD3_k127_1526055_5 adenyl ribonucleotide binding - - - 0.000000000000000000000000513 109.0
HKD3_k127_1526055_6 - - - - 0.0000000711 58.0
HKD3_k127_1526055_7 SpoVT / AbrB like domain - - - 0.0000005079 55.0
HKD3_k127_1580905_0 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008537 429.0
HKD3_k127_1580905_1 AAA domain (Cdc48 subfamily) K07392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 422.0
HKD3_k127_1580905_2 - - - - 0.000000000000000000000000000000000002013 149.0
HKD3_k127_1580905_3 membrane-associated protein domain - - - 0.0000000000000000000000000000006208 129.0
HKD3_k127_1580905_4 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000001215 87.0
HKD3_k127_1580905_5 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000001466 76.0
HKD3_k127_1614441_0 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000002211 177.0
HKD3_k127_1614441_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000003797 175.0
HKD3_k127_1614441_2 Belongs to the ParA family K03609 - - 0.0000000000000000000000000000000000000000002909 169.0
HKD3_k127_1614441_3 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000002647 154.0
HKD3_k127_1614441_4 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000000000000003249 146.0
HKD3_k127_1614441_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000001625 103.0
HKD3_k127_1614441_6 Type II/IV secretion system protein - - - 0.000000002074 66.0
HKD3_k127_1664448_0 HMGL-like K01649 - 2.3.3.13 1.01e-210 661.0
HKD3_k127_1664448_1 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001255 258.0
HKD3_k127_1664448_2 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000007384 219.0
HKD3_k127_1664448_3 TPR Domain containing protein - - - 0.000000000000000000000000000000000000000000000002725 185.0
HKD3_k127_1666916_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 401.0
HKD3_k127_1666916_1 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 377.0
HKD3_k127_1666916_2 SMART Elongator protein 3 MiaB NifB K06935 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007907 352.0
HKD3_k127_1666916_3 COGs COG0675 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 295.0
HKD3_k127_1666916_4 PFAM HhH-GPD family protein K07457 - - 0.0000000000000000000000000000000000000000000000000000000000006229 216.0
HKD3_k127_1666916_5 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000002689 201.0
HKD3_k127_1666916_6 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000003393 200.0
HKD3_k127_1666916_7 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000005329 112.0
HKD3_k127_1728409_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 449.0
HKD3_k127_1728409_1 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000000002864 185.0
HKD3_k127_1728409_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000002014 70.0
HKD3_k127_1741583_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 574.0
HKD3_k127_1741583_1 MviN-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 549.0
HKD3_k127_1741583_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 498.0
HKD3_k127_1741583_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 323.0
HKD3_k127_1741583_4 Glycosyltransferase 28 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 295.0
HKD3_k127_1741583_5 TIGRFAM methyltransferase FkbM family - - - 0.00000000000000000000000008273 115.0
HKD3_k127_1741583_6 Reverse transcriptase (RNA-dependent DNA polymerase) K00986 - 2.7.7.49 0.00000000000000000005468 90.0
HKD3_k127_1741583_7 Glycosyl transferase, family 2 K00721,K07011,K20444 - 2.4.1.83 0.0000000000004752 73.0
HKD3_k127_1741583_8 COG3451 Type IV secretory pathway, VirB4 components - - - 0.0003617 44.0
HKD3_k127_1741583_9 Reverse transcriptase (RNA-dependent DNA polymerase) K00986 - 2.7.7.49 0.0004845 45.0
HKD3_k127_1786530_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 598.0
HKD3_k127_1786530_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 348.0
HKD3_k127_1786530_2 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 302.0
HKD3_k127_1786530_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004462 261.0
HKD3_k127_1786530_4 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000007138 241.0
HKD3_k127_1786530_5 Fe-S cluster K04488 - - 0.0000000000000000000000000000000000000000000000000000000000004257 213.0
HKD3_k127_1786530_6 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000002011 176.0
HKD3_k127_1786530_7 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000001049 121.0
HKD3_k127_1786530_8 Transcriptional regulator K07108 - - 0.0000000000000000000002454 100.0
HKD3_k127_1786530_9 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000813 102.0
HKD3_k127_1801268_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 508.0
HKD3_k127_1801268_1 - - - - 0.00000000000000000000000000782 121.0
HKD3_k127_1801268_2 TIGRFAM addiction module toxin, RelE StbE family K19158 - - 0.00000000000000000000128 96.0
HKD3_k127_1840435_0 GHMP kinases C terminal K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 510.0
HKD3_k127_1840435_1 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005986 500.0
HKD3_k127_1840435_2 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 428.0
HKD3_k127_1840435_3 Pfam:Transaldolase K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 306.0
HKD3_k127_1840435_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K00216,K07124 - 1.1.1.100,1.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 305.0
HKD3_k127_1840435_5 D-glycero-D-manno-heptose 7-phosphate metabolic process K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001004 276.0
HKD3_k127_1840435_6 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000149 254.0
HKD3_k127_1840435_7 glycogen (starch) synthase activity K00693,K00696,K00754,K20430,K20444 - 2.4.1.11,2.4.1.14 0.00000000000000000000000000000000000000000000000000000002843 215.0
HKD3_k127_1840435_8 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000004434 155.0
HKD3_k127_1845027_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 488.0
HKD3_k127_1845027_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 365.0
HKD3_k127_1845027_2 Phage integrase family - - - 0.0000000004193 64.0
HKD3_k127_1847740_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 592.0
HKD3_k127_1847740_1 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 470.0
HKD3_k127_1847740_2 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000008713 259.0
HKD3_k127_1847740_3 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000000000000000000001746 181.0
HKD3_k127_1847740_4 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000000000000000000006983 142.0
HKD3_k127_1847740_5 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000005663 133.0
HKD3_k127_1847740_6 Belongs to the UPF0218 family K09735 - - 0.000000000000000000002303 96.0
HKD3_k127_1847740_7 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000004492 87.0
HKD3_k127_1847740_8 - - - - 0.000000008293 61.0
HKD3_k127_1910168_0 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 503.0
HKD3_k127_1910168_1 Male sterility protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 344.0
HKD3_k127_1910168_2 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000007536 236.0
HKD3_k127_1910168_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000238 207.0
HKD3_k127_1910168_4 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000001188 88.0
HKD3_k127_1910168_5 CopG antitoxin of type II toxin-antitoxin system - - - 0.000000000000000115 82.0
HKD3_k127_1910168_6 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000000007114 70.0
HKD3_k127_191223_0 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008055 432.0
HKD3_k127_191223_1 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000001593 203.0
HKD3_k127_191223_2 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000000000000000000000000001946 121.0
HKD3_k127_191223_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000001165 104.0
HKD3_k127_191223_4 - - - - 0.000000000000000000004551 105.0
HKD3_k127_191223_5 - - - - 0.0000000000000000001609 96.0
HKD3_k127_1954733_0 Putative zinc- or iron-chelating domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005249 238.0
HKD3_k127_1954733_1 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000001413 192.0
HKD3_k127_1954733_2 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000008394 183.0
HKD3_k127_1954733_3 amine dehydrogenase activity - - - 0.0000000000000000000000000007893 116.0
HKD3_k127_1993191_0 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000007544 237.0
HKD3_k127_1993191_1 Protein of unknown function (DUF2551) - - - 0.000000000000000000000000000000001848 131.0
HKD3_k127_1993191_2 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000001627 130.0
HKD3_k127_1993191_3 biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.000000015 60.0
HKD3_k127_200832_0 COG0589 Universal stress protein UspA and related nucleotide-binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000001436 231.0
HKD3_k127_200832_1 Protein of unknown function DUF84 - - - 0.0000000000000000000000000000000000004332 145.0
HKD3_k127_200832_2 Protein of unknown function (DUF1646) - - - 0.000000000000000000000000000000000002095 138.0
HKD3_k127_200832_3 - - - - 0.0000000000000000000000000193 119.0
HKD3_k127_2049287_0 ABC-type phosphate transport system, periplasmic component K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 386.0
HKD3_k127_2049287_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036,K02068,K06857 - 3.6.3.27,3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 357.0
HKD3_k127_2049287_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 355.0
HKD3_k127_2049287_3 phosphate transport system permease protein K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 342.0
HKD3_k127_2049287_4 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000002096 206.0
HKD3_k127_2052180_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 346.0
HKD3_k127_2052180_1 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 301.0
HKD3_k127_2052180_2 Pas domain K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000003492 282.0
HKD3_k127_2052180_3 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.00000000000000000000000000000000000001241 157.0
HKD3_k127_21268_0 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000008992 176.0
HKD3_k127_21268_1 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000002413 160.0
HKD3_k127_21268_2 Glycosyl transferases group 1 - - - 0.00000000000000000008818 99.0
HKD3_k127_2140974_0 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 431.0
HKD3_k127_2140974_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 355.0
HKD3_k127_2140974_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 353.0
HKD3_k127_2140974_3 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.0000000000000000000000000000000000000000000000002303 180.0
HKD3_k127_2140974_4 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000001952 71.0
HKD3_k127_2147891_0 Histidine kinase K00936 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003975 291.0
HKD3_k127_2147891_1 Pas domain K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000001158 239.0
HKD3_k127_2147891_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000001081 188.0
HKD3_k127_2147891_3 response regulator receiver - - - 0.0000000000000008016 81.0
HKD3_k127_2152041_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 361.0
HKD3_k127_2152041_1 protein-disulfide reductase activity - - - 0.00000000000000093 84.0
HKD3_k127_2176661_0 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 289.0
HKD3_k127_2176661_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000004842 242.0
HKD3_k127_2176661_2 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000000000000000000001113 227.0
HKD3_k127_2176661_3 Integral membrane sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000005785 208.0
HKD3_k127_2176661_4 cheY-homologous receiver domain K07668 - - 0.000000000000000000000000000000000000000008639 158.0
HKD3_k127_2176661_5 Carboxymuconolactone decarboxylase family - - - 0.000000000414 61.0
HKD3_k127_2255653_0 PFAM Circadian clock protein KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008893 321.0
HKD3_k127_2255653_1 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000002872 171.0
HKD3_k127_2255653_2 - - - - 0.0000000000000000000000000000000000007765 156.0
HKD3_k127_2255653_3 Subtilase family K13277 GO:0005575,GO:0005576 - 0.000000000000000000006537 100.0
HKD3_k127_2255653_4 Belongs to the acylphosphatase family - - - 0.00000000000000007349 86.0
HKD3_k127_2271751_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 4.704e-224 704.0
HKD3_k127_2271751_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 8.225e-213 667.0
HKD3_k127_228384_0 DEAD DEAH box helicase domain protein K05592,K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 548.0
HKD3_k127_228384_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008969 278.0
HKD3_k127_228384_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001253 263.0
HKD3_k127_228384_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000003157 177.0
HKD3_k127_228384_4 methyltransferase - - - 0.00000000000000000000000000000000000003403 149.0
HKD3_k127_2288904_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 454.0
HKD3_k127_2288904_1 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001132 286.0
HKD3_k127_2288904_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000002374 267.0
HKD3_k127_2288904_3 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000006461 222.0
HKD3_k127_2288904_5 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000004451 143.0
HKD3_k127_2288904_6 COG3316 Transposase and inactivated derivatives K07498 - - 0.000000000000000008728 91.0
HKD3_k127_2288904_7 COG3316 Transposase and inactivated derivatives K07498 - - 0.0000000000000002846 84.0
HKD3_k127_2288904_8 COG3316 Transposase and inactivated derivatives K07498 - - 0.0000000000004495 77.0
HKD3_k127_2288904_9 PFAM plasmid stabilization system K06218 - - 0.0001037 48.0
HKD3_k127_229879_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 415.0
HKD3_k127_229879_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 299.0
HKD3_k127_229879_2 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000001034 206.0
HKD3_k127_229879_3 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000004285 146.0
HKD3_k127_2311583_0 acid binding OB-fold tRNA helicase-type K07463 - - 7.126e-281 879.0
HKD3_k127_2311583_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 465.0
HKD3_k127_2311583_2 Elongator protein 3, MiaB family, Radical SAM K09711 - - 0.000000000000000000000000000000000000000000000000000004649 203.0
HKD3_k127_2311583_3 methyl-accepting chemotaxis protein K03406,K07652 - 2.7.13.3 0.00000000000000000000000000000000000000000000001415 180.0
HKD3_k127_2311583_4 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000004994 139.0
HKD3_k127_2311583_5 heme binding K21472 - - 0.0000000000000000000002672 107.0
HKD3_k127_2311583_6 - - - - 0.00000000000000009603 82.0
HKD3_k127_2311583_7 4Fe-4S binding domain - - - 0.0000000000000001538 80.0
HKD3_k127_2367788_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 9.224e-254 793.0
HKD3_k127_2367788_1 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 288.0
HKD3_k127_2367788_2 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000000000000000000004201 190.0
HKD3_k127_2367788_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000005397 101.0
HKD3_k127_2367788_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000001376 79.0
HKD3_k127_2396171_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 557.0
HKD3_k127_2396171_1 - - - - 0.000000000000000000000000000000000000000000000000000000002204 209.0
HKD3_k127_2397604_0 Amino acid permease - - - 9.902e-236 746.0
HKD3_k127_2397604_1 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000001152 127.0
HKD3_k127_2397604_2 - - - - 0.00000000000000004198 87.0
HKD3_k127_2397604_3 - - - - 0.0000001297 59.0
HKD3_k127_239823_0 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001779 252.0
HKD3_k127_239823_1 DsrE/DsrF-like family K07235 - - 0.0000000000000005197 82.0
HKD3_k127_239823_2 Belongs to the sulfur carrier protein TusA family - GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0019725,GO:0033554,GO:0042592,GO:0048878,GO:0050896,GO:0051716,GO:0055082,GO:0065007,GO:0065008 - 0.00000000000003623 74.0
HKD3_k127_239823_3 - - - - 0.00001097 56.0
HKD3_k127_239823_4 DsrE/DsrF-like family - - - 0.0002898 49.0
HKD3_k127_240970_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.493e-270 846.0
HKD3_k127_240970_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000005426 215.0
HKD3_k127_240970_2 COG1226 Kef-type K transport systems - - - 0.0000000000000000000000000000000000000005627 161.0
HKD3_k127_240970_3 - - - - 0.00000000000000000000000000000000000023 145.0
HKD3_k127_240970_4 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.00000001381 57.0
HKD3_k127_240970_5 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.000000276 54.0
HKD3_k127_2412462_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000001079 262.0
HKD3_k127_2412462_1 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000000492 223.0
HKD3_k127_2412462_2 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000000000000006196 221.0
HKD3_k127_2412462_3 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000000000000001469 224.0
HKD3_k127_2412462_4 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000002337 131.0
HKD3_k127_2412462_5 PQ loop repeat K15383 - - 0.0000000000000003898 82.0
HKD3_k127_2447536_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 391.0
HKD3_k127_2447536_1 PFAM Patatin K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 390.0
HKD3_k127_2447536_2 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000003464 145.0
HKD3_k127_2447536_3 OsmC-like protein - - - 0.0000000000000000000000004446 106.0
HKD3_k127_2447536_4 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000001009 98.0
HKD3_k127_2447536_5 redox protein, regulator of disulfide bond formation - - - 0.0000000000008206 70.0
HKD3_k127_2447536_6 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000001411 58.0
HKD3_k127_2477556_0 KH, type 1, domain K07041 - - 0.0 1004.0
HKD3_k127_2477556_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 299.0
HKD3_k127_2477556_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000522 121.0
HKD3_k127_2477556_3 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0000000000000000000000000006105 114.0
HKD3_k127_2524929_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.613e-227 709.0
HKD3_k127_2524929_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 1.167e-197 620.0
HKD3_k127_2524929_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 436.0
HKD3_k127_2524929_3 Leucyl aminopeptidase (Aminopeptidase t) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 303.0
HKD3_k127_2524929_4 Mechanosensitive ion channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001333 263.0
HKD3_k127_2524929_5 hydroxylamine reductase activity K00198 - 1.2.7.4 0.00000000000000000000000000000000000000003355 162.0
HKD3_k127_2524929_6 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000234 123.0
HKD3_k127_2524929_7 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000003781 113.0
HKD3_k127_2524929_8 - - - - 0.0000000000005533 69.0
HKD3_k127_2524929_9 - - - - 0.00003714 49.0
HKD3_k127_2529320_0 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 332.0
HKD3_k127_2529320_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007792 238.0
HKD3_k127_2529320_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000002165 198.0
HKD3_k127_2529320_3 COG3316 Transposase and inactivated derivatives - - - 0.000000000000000000000000002855 124.0
HKD3_k127_2560029_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 443.0
HKD3_k127_2560029_1 - - - - 0.00000000000000000000000000000000000005568 158.0
HKD3_k127_2560029_2 TPR Domain containing protein - - - 0.00000000000000000000000000001042 120.0
HKD3_k127_25698_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 4.262e-292 912.0
HKD3_k127_25698_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 527.0
HKD3_k127_25698_2 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 510.0
HKD3_k127_25698_3 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 416.0
HKD3_k127_25698_4 PFAM Radical SAM domain protein K03716 - 4.1.99.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 322.0
HKD3_k127_25698_5 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001158 253.0
HKD3_k127_25698_6 Helix-turn-helix XRE-family like proteins K03627 - - 0.00000000000000000000000000000000000000000001058 171.0
HKD3_k127_25698_7 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000003088 127.0
HKD3_k127_25698_8 Roadblock LC7 family protein K07131 - - 0.000000000000000003633 89.0
HKD3_k127_25698_9 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000009448 51.0
HKD3_k127_2590225_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 3.004e-209 663.0
HKD3_k127_2590225_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.285e-199 639.0
HKD3_k127_2590225_10 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000003844 84.0
HKD3_k127_2590225_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001566 87.0
HKD3_k127_2590225_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 464.0
HKD3_k127_2590225_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 410.0
HKD3_k127_2590225_4 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 302.0
HKD3_k127_2590225_5 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 302.0
HKD3_k127_2590225_6 Protein of unknown function (DUF531) K09725 - - 0.0000000000000000000000000000000000000000000000000000000000000001436 225.0
HKD3_k127_2590225_7 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000003852 198.0
HKD3_k127_2590225_8 - - - - 0.00000000000000000000000000000000000006389 152.0
HKD3_k127_2590225_9 Belongs to the acylphosphatase family - - - 0.00000000000000000000000000000000003476 140.0
HKD3_k127_2611826_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 481.0
HKD3_k127_2611826_1 protein conserved in archaea K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002661 259.0
HKD3_k127_2611826_3 - - - - 0.000000000041 67.0
HKD3_k127_263767_0 AAA-like domain K06915 - - 2.001e-201 638.0
HKD3_k127_263767_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009718 497.0
HKD3_k127_263767_11 Rieske 2Fe-2S - - - 0.0000000000000000000000000000006127 127.0
HKD3_k127_263767_12 Glutaredoxin - - - 0.000000000000000000000000002977 112.0
HKD3_k127_263767_13 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000000000001106 106.0
HKD3_k127_263767_14 - - - - 0.000000000000000000001032 96.0
HKD3_k127_263767_15 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000000001281 89.0
HKD3_k127_263767_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 286.0
HKD3_k127_263767_3 TIGRFAM archaeoflavoprotein AfpA - - - 0.0000000000000000000000000000000000000000000000000000000000000001868 225.0
HKD3_k127_263767_4 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000002701 202.0
HKD3_k127_263767_5 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000003467 175.0
HKD3_k127_263767_6 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000009762 180.0
HKD3_k127_263767_7 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000000000000000001566 172.0
HKD3_k127_263767_8 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000003859 176.0
HKD3_k127_263767_9 Rieske-like [2Fe-2S] domain - - - 0.0000000000000000000000000000000001883 135.0
HKD3_k127_2639154_0 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 7.667e-232 736.0
HKD3_k127_2639154_1 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 550.0
HKD3_k127_2639154_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000003006 105.0
HKD3_k127_2639154_11 Transcriptional regulator, TrmB - - - 0.0000000000000000000000004165 109.0
HKD3_k127_2639154_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 495.0
HKD3_k127_2639154_3 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 470.0
HKD3_k127_2639154_4 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 393.0
HKD3_k127_2639154_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 296.0
HKD3_k127_2639154_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001418 246.0
HKD3_k127_2639154_7 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000001225 213.0
HKD3_k127_2639154_8 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000002518 214.0
HKD3_k127_2639154_9 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000166 159.0
HKD3_k127_2676669_0 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 571.0
HKD3_k127_2676669_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 475.0
HKD3_k127_2676669_10 - - - - 0.000000000000000000000001353 104.0
HKD3_k127_2676669_11 Transcriptional regulator, TrmB - - - 0.0000000000000000000003584 100.0
HKD3_k127_2676669_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008472 441.0
HKD3_k127_2676669_3 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 392.0
HKD3_k127_2676669_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 351.0
HKD3_k127_2676669_5 Belongs to the peptidase S16 family K06870 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 350.0
HKD3_k127_2676669_6 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000833 301.0
HKD3_k127_2676669_7 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004619 276.0
HKD3_k127_2676669_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001025 254.0
HKD3_k127_2676669_9 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000000000000000007008 166.0
HKD3_k127_268144_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.814e-318 995.0
HKD3_k127_268144_1 Pfam:DUF650 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006177 522.0
HKD3_k127_268144_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004798 263.0
HKD3_k127_268144_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003301 246.0
HKD3_k127_268144_4 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.000000000000000000000000000000000000000000000000000000000001919 221.0
HKD3_k127_268144_5 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000002616 198.0
HKD3_k127_268144_6 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000001292 143.0
HKD3_k127_268144_7 Protein of unknown function (DUF3795) - - - 0.000000000000000000000002114 106.0
HKD3_k127_2708274_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K22167 - 1.5.98.3 1.57e-232 736.0
HKD3_k127_2708274_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 411.0
HKD3_k127_2708274_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 321.0
HKD3_k127_2708274_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K22166 - 1.5.98.3 0.00000000000000000000000000000001085 129.0
HKD3_k127_2708274_4 Proton-conducting membrane transporter K22168 - 1.5.98.3 0.000000000000000000000000000008978 122.0
HKD3_k127_2708274_5 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000000000000000000000004531 110.0
HKD3_k127_2708274_6 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.0000000000004431 70.0
HKD3_k127_2708274_7 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.0000000000005034 71.0
HKD3_k127_2757082_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 624.0
HKD3_k127_2757082_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 515.0
HKD3_k127_2757082_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000001841 212.0
HKD3_k127_2757082_3 GYD domain - - - 0.00000000000000000000000000001852 119.0
HKD3_k127_2757082_4 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000002444 116.0
HKD3_k127_2757082_5 von Willebrand factor, type A K07114 - - 0.000000000000000001925 88.0
HKD3_k127_2804198_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 9.639e-196 615.0
HKD3_k127_2804198_1 Radical SAM K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 508.0
HKD3_k127_2804198_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000000000000000000000000000000000000001908 207.0
HKD3_k127_2804198_3 C-terminal AAA-associated domain K02049 - - 0.0000000000000464 78.0
HKD3_k127_2804198_4 Protein of unknown function (DUF433) - - - 0.00000000006164 65.0
HKD3_k127_2804198_5 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000001539 62.0
HKD3_k127_2819225_0 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 489.0
HKD3_k127_2819225_1 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001371 234.0
HKD3_k127_2819225_2 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000000004508 101.0
HKD3_k127_2819225_3 - - - - 0.000000001144 68.0
HKD3_k127_2843567_0 ATPase, P-type transporting, HAD superfamily, subfamily IC K01531,K01535 - 3.6.3.2,3.6.3.6 3.813e-211 670.0
HKD3_k127_2843567_1 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 526.0
HKD3_k127_2843567_2 PHB de-polymerase C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 425.0
HKD3_k127_2878579_0 ATPase domain predominantly from Archaea K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 468.0
HKD3_k127_2878579_1 Iron-sulfur cluster-binding domain K06139 - - 0.0000000000000000000000000000000000000000000000005397 194.0
HKD3_k127_2878579_2 Domain of unknown function (DUF2341) - - - 0.0000002052 55.0
HKD3_k127_2878579_3 - - - - 0.0000179 53.0
HKD3_k127_2885052_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 477.0
HKD3_k127_2885052_1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 288.0
HKD3_k127_2885052_2 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001086 270.0
HKD3_k127_2885052_3 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000003329 222.0
HKD3_k127_2885052_4 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000002313 142.0
HKD3_k127_2885052_5 Winged helix-turn-helix DNA-binding - - - 0.00000000000000000000000000000000001179 145.0
HKD3_k127_2885052_6 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000001695 139.0
HKD3_k127_2885052_7 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000012 136.0
HKD3_k127_2885052_8 - - - - 0.0000000000000001041 93.0
HKD3_k127_288981_0 helicase superfamily c-terminal domain - - - 2.129e-203 638.0
HKD3_k127_288981_1 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 485.0
HKD3_k127_288981_2 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000001207 238.0
HKD3_k127_291668_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 446.0
HKD3_k127_291668_1 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 325.0
HKD3_k127_291668_2 abc transporter atp-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000002588 243.0
HKD3_k127_291668_3 - - - - 0.00000000000000000000000000000003613 139.0
HKD3_k127_291668_4 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.000000000000000000000000001262 119.0
HKD3_k127_291668_5 Double zinc ribbon - - - 0.000000000000000000000000001589 119.0
HKD3_k127_291668_6 PFAM response regulator receiver - - - 0.00000000000001199 82.0
HKD3_k127_291668_7 - - - - 0.000000000001144 77.0
HKD3_k127_297492_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 473.0
HKD3_k127_297492_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 445.0
HKD3_k127_297492_2 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 351.0
HKD3_k127_299920_0 Beta-Casp domain K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 413.0
HKD3_k127_299920_1 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 305.0
HKD3_k127_299920_10 Iron-sulphur cluster biosynthesis K15724 - - 0.0000000000000000000000000006697 115.0
HKD3_k127_299920_11 COGs COG0675 Transposase and inactivated derivatives - - - 0.0000000000000000000000000007125 117.0
HKD3_k127_299920_12 Protein of unknown function (DUF2551) - - - 0.000000000000000000000001739 106.0
HKD3_k127_299920_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000004762 245.0
HKD3_k127_299920_3 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004582 253.0
HKD3_k127_299920_4 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000000000000000033 209.0
HKD3_k127_299920_5 - - - - 0.000000000000000000000000000000000000000000000001835 177.0
HKD3_k127_299920_6 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.0000000000000000000000000000000000000000000007339 171.0
HKD3_k127_299920_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000009266 176.0
HKD3_k127_299920_8 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000012 138.0
HKD3_k127_299920_9 COGs COG0675 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000002811 130.0
HKD3_k127_302106_0 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000001741 233.0
HKD3_k127_302106_1 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000111 211.0
HKD3_k127_302106_2 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000001414 122.0
HKD3_k127_302106_3 S-layer protein - - - 0.0000000000000000002183 102.0
HKD3_k127_302106_4 - - - - 0.00000000000001861 78.0
HKD3_k127_3038141_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 310.0
HKD3_k127_3038141_1 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004 297.0
HKD3_k127_3038141_2 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000006735 143.0
HKD3_k127_3038141_3 transcriptional K07729 - - 0.0000000000000000000000123 106.0
HKD3_k127_3038141_4 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000001507 100.0
HKD3_k127_3038141_5 flagella protein K07327 - - 0.000000003142 65.0
HKD3_k127_3061295_0 - - - - 2.238e-282 887.0
HKD3_k127_3061295_1 Segregation and condensation complex subunit ScpB K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 396.0
HKD3_k127_3061295_2 Segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000000000000000000008417 208.0
HKD3_k127_3061295_3 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000003705 141.0
HKD3_k127_3063287_0 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 616.0
HKD3_k127_3063287_1 PFAM Phage tail sheath protein K06907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 408.0
HKD3_k127_3063287_2 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 303.0
HKD3_k127_3063287_3 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002247 231.0
HKD3_k127_3063287_4 - - - - 0.00000000000000000000000000000000000000000000000000005144 188.0
HKD3_k127_3063287_5 Transposase domain (DUF772) K07481 - - 0.0000000008497 64.0
HKD3_k127_3063287_6 - - - - 0.000000002313 58.0
HKD3_k127_307201_0 Reverse transcriptase (RNA-dependent DNA polymerase) K00986 - 2.7.7.49 1.156e-216 686.0
HKD3_k127_307201_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 523.0
HKD3_k127_307201_2 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 428.0
HKD3_k127_307201_3 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002846 288.0
HKD3_k127_307201_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000007623 241.0
HKD3_k127_307201_5 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000000000000000000000000009984 233.0
HKD3_k127_307201_6 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000006959 224.0
HKD3_k127_307201_7 Mechanosensitive ion channel K16052 - - 0.00000000000000000000009084 108.0
HKD3_k127_307201_8 - - - - 0.00000000000000000002656 93.0
HKD3_k127_3076329_0 Pyruvate dehydrogenase E1 K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 402.0
HKD3_k127_3076329_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K01784,K12450 - 4.2.1.46,4.2.1.76,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009099 387.0
HKD3_k127_3076329_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 312.0
HKD3_k127_3076329_3 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 289.0
HKD3_k127_3076329_4 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000002527 235.0
HKD3_k127_3076329_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000001226 222.0
HKD3_k127_3076329_6 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000005913 190.0
HKD3_k127_3076329_7 Nad-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000004789 148.0
HKD3_k127_3076329_8 Transposase DDE domain K07492 - - 0.00000000000000000000000000008688 116.0
HKD3_k127_3076329_9 radical SAM domain protein - - - 0.0000000000003286 81.0
HKD3_k127_3086622_0 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 288.0
HKD3_k127_3086622_1 PFAM TPR repeat-containing protein - - - 0.0000000000000004097 90.0
HKD3_k127_3092326_0 Methionine gamma-lyase K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 396.0
HKD3_k127_3092326_1 Belongs to the aconitase IPM isomerase family K01682 - 4.2.1.3,4.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 308.0
HKD3_k127_3148481_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000007784 265.0
HKD3_k127_3148481_1 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000003846 187.0
HKD3_k127_3148481_2 formate dehydrogenase K03620 - - 0.00000000000007695 79.0
HKD3_k127_3148481_3 response to heat - - - 0.00000000000131 71.0
HKD3_k127_3168529_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 6.639e-201 633.0
HKD3_k127_3168529_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 299.0
HKD3_k127_3168529_2 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002007 236.0
HKD3_k127_3228191_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 3.716e-199 629.0
HKD3_k127_3228191_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005736 523.0
HKD3_k127_3228191_2 - - - - 0.000000000000000000000000000006516 120.0
HKD3_k127_324376_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 304.0
HKD3_k127_324376_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 303.0
HKD3_k127_324376_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001915 292.0
HKD3_k127_324376_3 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
HKD3_k127_324376_4 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000001192 151.0
HKD3_k127_324376_5 extracellular matrix structural constituent - - - 0.00000000000000000000000000000003819 139.0
HKD3_k127_324376_6 Zn-dependent protease with chaperone function K03799 - - 0.000000000000000000005371 102.0
HKD3_k127_324376_7 negative regulation of transcription, DNA-templated - - - 0.000000000000000000009171 97.0
HKD3_k127_324376_8 Transcriptional regulator - - - 0.0000000000000001869 85.0
HKD3_k127_3244085_1 involved in chromosome partitioning K03496 - - 0.00000001455 66.0
HKD3_k127_3256105_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 331.0
HKD3_k127_3256105_1 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000001552 261.0
HKD3_k127_3256105_2 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000004529 208.0
HKD3_k127_3262445_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 499.0
HKD3_k127_3262445_1 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 406.0
HKD3_k127_3275005_0 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 263.0
HKD3_k127_3275005_1 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000001297 246.0
HKD3_k127_3275005_2 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000000001861 202.0
HKD3_k127_3275005_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000001954 181.0
HKD3_k127_3275005_4 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000001079 132.0
HKD3_k127_32919_0 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000002996 161.0
HKD3_k127_3296600_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 565.0
HKD3_k127_3296600_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 400.0
HKD3_k127_3296600_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 333.0
HKD3_k127_3296600_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000007171 186.0
HKD3_k127_3296600_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000008747 154.0
HKD3_k127_3296600_5 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000000004699 154.0
HKD3_k127_3302168_0 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 476.0
HKD3_k127_3337501_0 Pyruvate phosphate dikinase, PEP pyruvate binding domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 603.0
HKD3_k127_3337501_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 444.0
HKD3_k127_3337501_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687,K04043 - - 0.00000000000000000000000000000000000000000002136 171.0
HKD3_k127_3337501_3 Heat shock 70 kDa protein - - - 0.000000000000000000000000000000005741 128.0
HKD3_k127_3550010_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 528.0
HKD3_k127_3550010_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 441.0
HKD3_k127_3550010_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 398.0
HKD3_k127_3550010_3 COG3547 Transposase and inactivated derivatives - - - 0.000000000000000000001437 98.0
HKD3_k127_3550010_4 COG3547 Transposase and inactivated derivatives - - - 0.000000000000000004032 87.0
HKD3_k127_3550010_5 - - - - 0.00002976 46.0
HKD3_k127_3550010_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0005693 43.0
HKD3_k127_3581845_0 Probable transposase K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 364.0
HKD3_k127_3581845_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000001083 213.0
HKD3_k127_3581845_2 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000007607 167.0
HKD3_k127_3581845_3 COG0852 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.0000000000000000000000000000000001259 137.0
HKD3_k127_3581845_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000001253 127.0
HKD3_k127_361004_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 314.0
HKD3_k127_361004_1 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.0000000000000000000000000000000000000000000000000000000005672 207.0
HKD3_k127_361004_2 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000002787 175.0
HKD3_k127_361004_3 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000004105 103.0
HKD3_k127_361004_4 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000000005663 87.0
HKD3_k127_3667354_0 Chemotaxis protein CheA K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 544.0
HKD3_k127_3667354_1 type II secretion system protein K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 454.0
HKD3_k127_3667354_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 391.0
HKD3_k127_3667354_3 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000217 282.0
HKD3_k127_3667354_4 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000000000000000000000000000000000000000000001168 200.0
HKD3_k127_3667354_5 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000000000000000000000000000006677 167.0
HKD3_k127_3667354_6 PFAM response regulator receiver K03413 - - 0.0000000000000000000000000000000000000008021 151.0
HKD3_k127_3667354_7 CheC inhibitor of MCP methylation K03410 - - 0.000000000000000000000000000000000003784 145.0
HKD3_k127_3692814_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 3.035e-264 850.0
HKD3_k127_3692814_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 9.831e-222 700.0
HKD3_k127_3692814_2 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 536.0
HKD3_k127_3692814_3 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 337.0
HKD3_k127_3692814_4 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000002289 121.0
HKD3_k127_3692814_5 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000000005395 109.0
HKD3_k127_3720086_0 DEAD DEAH box helicase domain protein K10896 - - 5.842e-281 883.0
HKD3_k127_3720086_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 7.493e-210 662.0
HKD3_k127_3720086_10 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000000000000003076 132.0
HKD3_k127_3720086_11 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000000000001539 118.0
HKD3_k127_3720086_12 Winged helix-turn-helix DNA-binding - - - 0.00000000000000003527 85.0
HKD3_k127_3720086_14 TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit K00241 - - 0.000000000926 63.0
HKD3_k127_3720086_2 radical SAM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 390.0
HKD3_k127_3720086_3 Subtilase family K13277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 315.0
HKD3_k127_3720086_4 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000216 254.0
HKD3_k127_3720086_5 COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000002202 220.0
HKD3_k127_3720086_6 nucleic acid-binding protein contains PIN domain - - - 0.000000000000000000000000000000000000000000002128 169.0
HKD3_k127_3720086_7 PFAM peptidase - - - 0.000000000000000000000000000000000000003046 153.0
HKD3_k127_3720086_8 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000002472 144.0
HKD3_k127_3720086_9 Uncharacterised protein family (UPF0175) - - - 0.0000000000000000000000000000000002903 133.0
HKD3_k127_372377_0 Resolvase, N terminal domain K07450 - - 0.0000000000000000000000000000000000000000107 161.0
HKD3_k127_372377_1 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.000000000000000000000000000001507 129.0
HKD3_k127_372377_2 Cupredoxin-like domain - - - 0.000000000000000000000000009676 115.0
HKD3_k127_372377_3 Transposase - - - 0.00000000000000000000006672 112.0
HKD3_k127_372377_4 COG1138 Cytochrome c biogenesis factor K02198 - - 0.000000000000002219 83.0
HKD3_k127_372377_5 Cytochrome C biogenesis protein K02200 - - 0.0000000000005784 74.0
HKD3_k127_372377_6 Cytochrome C biogenesis protein K02200 - - 0.00000000001988 70.0
HKD3_k127_372377_7 SdrD B-like domain - - - 0.0000002658 63.0
HKD3_k127_3726945_0 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 523.0
HKD3_k127_3726945_1 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 290.0
HKD3_k127_3726945_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005326 260.0
HKD3_k127_3726945_3 Thiamine-binding protein - - - 0.0000000000000000000000008727 108.0
HKD3_k127_3726945_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000001391 94.0
HKD3_k127_3729044_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 509.0
HKD3_k127_3729044_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 487.0
HKD3_k127_3729044_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 476.0
HKD3_k127_3729044_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000002487 233.0
HKD3_k127_3729044_4 - - - - 0.0009163 43.0
HKD3_k127_3737435_0 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 512.0
HKD3_k127_3737435_1 PHB de-polymerase C-terminus K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 424.0
HKD3_k127_3737435_2 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 329.0
HKD3_k127_3737435_3 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 287.0
HKD3_k127_3737435_4 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.000004603 51.0
HKD3_k127_3741855_0 Cys/Met metabolism PLP-dependent enzyme K19793 - 2.6.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 433.0
HKD3_k127_3741855_1 Conserved hypothetical ATP binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000103 265.0
HKD3_k127_3741855_2 4-hydroxybenzoate polyprenyltransferase K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000002426 262.0
HKD3_k127_3741855_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000008244 244.0
HKD3_k127_3741855_4 membrane - - - 0.00000000885 67.0
HKD3_k127_3750086_0 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 504.0
HKD3_k127_3750086_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 477.0
HKD3_k127_3750086_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 439.0
HKD3_k127_3750086_3 Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000005555 250.0
HKD3_k127_3769542_0 flagella protein K07327,K07328 - - 0.00000000000000000000000000000000000000000000000000004629 201.0
HKD3_k127_3769542_1 - - - - 0.00000000000000000000000001721 125.0
HKD3_k127_3769542_2 E-Z type HEAT repeats - - - 0.0000000000157 78.0
HKD3_k127_3769542_4 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000002722 62.0
HKD3_k127_3770563_0 Pfam:KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 602.0
HKD3_k127_3770563_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000113 246.0
HKD3_k127_3770563_2 KaiB K08481 - - 0.000000000000000000000000000000000000000001352 158.0
HKD3_k127_3770563_3 KaiB K08481 - - 0.000000000000000000000000000000006976 130.0
HKD3_k127_3772780_0 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 503.0
HKD3_k127_3772780_1 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 362.0
HKD3_k127_3772780_2 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 344.0
HKD3_k127_3772780_3 CcmB protein K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003111 257.0
HKD3_k127_3772780_4 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000002154 248.0
HKD3_k127_3772780_6 Acylphosphatase K01512 - 3.6.1.7 0.00006065 51.0
HKD3_k127_3785070_0 Peptidase U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 460.0
HKD3_k127_3785070_1 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000001799 121.0
HKD3_k127_3785070_2 Xylose isomerase-like TIM barrel - - - 0.0000000000000001926 80.0
HKD3_k127_3785070_3 Sporulation protein YtfJ - - - 0.00000000000002355 78.0
HKD3_k127_3785070_4 Protein of unknown function (DUF2953) - - - 0.000000000001102 76.0
HKD3_k127_3785070_5 - - - - 0.000000000004629 68.0
HKD3_k127_3785070_6 - - - - 0.000009181 51.0
HKD3_k127_3787856_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 413.0
HKD3_k127_3787856_1 GDP dissociation inhibitor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 387.0
HKD3_k127_3787856_2 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000007839 191.0
HKD3_k127_3799776_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 587.0
HKD3_k127_3799776_1 PFAM dihydropteroate synthase, DHPS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 533.0
HKD3_k127_3799776_10 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000000000000000000009296 123.0
HKD3_k127_3799776_11 CAAX protease self-immunity K07052 - - 0.0000000000000000006141 96.0
HKD3_k127_3799776_12 DNA alkylation repair enzyme - - - 0.000000000000000002124 85.0
HKD3_k127_3799776_13 small multi-drug export - - - 0.0000000000000001035 85.0
HKD3_k127_3799776_2 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 447.0
HKD3_k127_3799776_3 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 396.0
HKD3_k127_3799776_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 312.0
HKD3_k127_3799776_5 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000007746 260.0
HKD3_k127_3799776_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009784 247.0
HKD3_k127_3799776_7 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000001054 230.0
HKD3_k127_3799776_8 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000005677 182.0
HKD3_k127_3799776_9 retrograde transport, endosome to Golgi - - - 0.000000000000000000000000000000007193 133.0
HKD3_k127_3802092_0 SMART Elongator protein 3 MiaB NifB - - - 2.914e-244 764.0
HKD3_k127_3802092_1 Eco57I restriction-modification methylase K07317 - 2.1.1.72 0.00000002378 64.0
HKD3_k127_3839072_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 428.0
HKD3_k127_3839072_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 423.0
HKD3_k127_3839072_2 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000251 260.0
HKD3_k127_3839072_3 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000001652 190.0
HKD3_k127_3891681_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 5.874e-289 904.0
HKD3_k127_3891681_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000002451 124.0
HKD3_k127_3891681_2 - - - - 0.0000000000000000001799 94.0
HKD3_k127_3905131_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.789e-251 791.0
HKD3_k127_3905131_1 Uncharacterised protein family (UPF0014) K02069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 321.0
HKD3_k127_3905131_10 Transcriptional regulator - - - 0.00001261 49.0
HKD3_k127_3905131_2 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000148 280.0
HKD3_k127_3905131_3 ATPases associated with a variety of cellular activities K02068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005936 259.0
HKD3_k127_3905131_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000007343 238.0
HKD3_k127_3905131_5 KaiC K07331 - - 0.00000000000000000000000000000000000000000000000000000000000000000456 233.0
HKD3_k127_3905131_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000001163 108.0
HKD3_k127_3905131_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000008187 79.0
HKD3_k127_3905131_8 Cupin 2, conserved barrel domain protein - - - 0.00000000001345 69.0
HKD3_k127_3905131_9 Hypothetical methyltransferase - - - 0.00000003596 63.0
HKD3_k127_3936265_0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000000000000009777 208.0
HKD3_k127_3936265_1 iron dependent repressor K03709 - - 0.000000000000000000000000000000000001561 144.0
HKD3_k127_3936265_2 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.0000000000000000000000000001558 118.0
HKD3_k127_3936560_0 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 415.0
HKD3_k127_3936560_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005606 233.0
HKD3_k127_3936598_0 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 535.0
HKD3_k127_3936598_1 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000003227 181.0
HKD3_k127_3936598_2 4Fe-4S binding domain - - - 0.00000000000000001672 83.0
HKD3_k127_3936598_3 Phage integrase family - - - 0.00000000000396 74.0
HKD3_k127_3937636_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1258.0
HKD3_k127_3937636_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 589.0
HKD3_k127_3937636_2 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000004663 181.0
HKD3_k127_3937636_3 - - - - 0.0000002983 61.0
HKD3_k127_3946710_0 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000001783 201.0
HKD3_k127_3946710_1 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000002998 179.0
HKD3_k127_3946710_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000001039 68.0
HKD3_k127_3954415_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 584.0
HKD3_k127_3954415_1 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 314.0
HKD3_k127_3954415_2 Belongs to the peptidase S16 family K06870 - - 0.0000000000001768 80.0
HKD3_k127_3965947_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 389.0
HKD3_k127_3965947_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000003564 259.0
HKD3_k127_3968252_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 616.0
HKD3_k127_3968252_1 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 299.0
HKD3_k127_3968252_2 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.0000000000000000000000000000000000000000000000000000000000000000000002956 245.0
HKD3_k127_3968252_3 DGC domain - - - 0.0000000000000000000000000000000000000000000000000000003556 197.0
HKD3_k127_3968252_4 Acetyltransferase (Isoleucine patch superfamily) K00661 - 2.3.1.79 0.0000000000000000000000000000000004291 138.0
HKD3_k127_3969495_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 562.0
HKD3_k127_3969495_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 433.0
HKD3_k127_3969495_2 Protein-export membrane protein SecD K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 332.0
HKD3_k127_3969495_3 Protein of unknown function (DUF1016) - - - 0.00001336 48.0
HKD3_k127_3978790_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 576.0
HKD3_k127_3978790_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 430.0
HKD3_k127_3978790_10 - K07341 - - 0.0000000000007098 74.0
HKD3_k127_3978790_11 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.00000000001198 65.0
HKD3_k127_3978790_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 363.0
HKD3_k127_3978790_3 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 288.0
HKD3_k127_3978790_4 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000002327 200.0
HKD3_k127_3978790_5 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000000005628 163.0
HKD3_k127_3978790_6 - - - - 0.000000000000000000000000000000000000633 144.0
HKD3_k127_3978790_7 Nucleotidyl transferase AbiEii toxin, Type IV TA system K09144 - - 0.00000000000000000000000000000000412 138.0
HKD3_k127_3978790_8 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000000000007164 120.0
HKD3_k127_3978790_9 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000385 120.0
HKD3_k127_4000014_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 439.0
HKD3_k127_4049113_0 Involved in cell shape control K22222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 458.0
HKD3_k127_4049113_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 336.0
HKD3_k127_4049113_2 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 296.0
HKD3_k127_4049113_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000002439 169.0
HKD3_k127_4049113_4 4 iron, 4 sulfur cluster binding K11260 - - 0.000000000000000000000009618 102.0
HKD3_k127_4049113_5 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000123 94.0
HKD3_k127_4049113_6 - - - - 0.0000000000006587 80.0
HKD3_k127_4049113_7 - - - - 0.00000000002124 76.0
HKD3_k127_4054892_0 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 364.0
HKD3_k127_4054892_1 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 336.0
HKD3_k127_4054892_2 - - - - 0.00000000000000000000000000000005751 142.0
HKD3_k127_4054892_3 - - - - 0.00000000000000000000000000001764 134.0
HKD3_k127_4054892_4 PFAM Cytochrome c, bacterial - - - 0.000000000000003012 85.0
HKD3_k127_4054981_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 585.0
HKD3_k127_4054981_1 Probable transposase K07496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 353.0
HKD3_k127_4054981_2 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 291.0
HKD3_k127_4054981_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000001118 252.0
HKD3_k127_4054981_4 Gar1/Naf1 RNA binding region K07569 - - 0.000000000001874 71.0
HKD3_k127_4141472_0 Belongs to the N(4) N(6)-methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000003205 214.0
HKD3_k127_4141472_1 - - - - 0.00000000000000000000002661 106.0
HKD3_k127_4141472_2 phage integrase family - - - 0.0006758 48.0
HKD3_k127_4236526_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008313 238.0
HKD3_k127_4236526_1 Protein of unknown function (DUF1673) - - - 0.0000000000000000001013 96.0
HKD3_k127_4236526_2 Outer membrane lipoprotein-sorting protein - - - 0.00000000003937 74.0
HKD3_k127_4236526_3 protein conserved in archaea - - - 0.00000004266 58.0
HKD3_k127_4240980_0 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 400.0
HKD3_k127_4240980_1 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 310.0
HKD3_k127_4240980_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000104 257.0
HKD3_k127_4240980_3 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000006085 246.0
HKD3_k127_4240980_4 - - - - 0.0000000000000000000000000000000000000000000000000000009415 194.0
HKD3_k127_4240980_5 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000001384 160.0
HKD3_k127_4262020_0 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 432.0
HKD3_k127_4262020_1 - - - - 0.0000000000007688 79.0
HKD3_k127_4289648_0 Belongs to the ParB family K03497 GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 - 0.000000000000000000000000000000000001601 155.0
HKD3_k127_4289648_2 HNH nucleases - - - 0.000004433 51.0
HKD3_k127_4289648_3 SpoVT / AbrB like domain - - - 0.00006289 46.0
HKD3_k127_4311565_0 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007124 316.0
HKD3_k127_4311565_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 291.0
HKD3_k127_4311565_2 protein conserved in archaea - - - 0.0000000000000000000000000001579 123.0
HKD3_k127_4311565_3 Helix-turn-helix XRE-family like proteins K07729 - - 0.0000000000000000000000002987 106.0
HKD3_k127_4311565_4 - - - - 0.00000000000000000001857 95.0
HKD3_k127_4311565_5 ABC-2 family transporter protein K01992 - - 0.000000000000000003924 89.0
HKD3_k127_4311565_6 protein conserved in archaea - - - 0.000000000000001312 86.0
HKD3_k127_4312067_0 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 553.0
HKD3_k127_4312067_1 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 315.0
HKD3_k127_4312067_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000002724 133.0
HKD3_k127_4344973_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 444.0
HKD3_k127_4344973_1 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000004221 74.0
HKD3_k127_43734_0 PFAM AIR synthase related protein K07388 - - 3.495e-206 650.0
HKD3_k127_43734_1 PFAM Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002185 280.0
HKD3_k127_43734_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000212 252.0
HKD3_k127_43734_3 SWIM zinc finger - - - 0.0000000000000000000000000000000000003724 158.0
HKD3_k127_43734_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000005707 57.0
HKD3_k127_4403520_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009913 590.0
HKD3_k127_4403520_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 411.0
HKD3_k127_4403520_2 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000878 259.0
HKD3_k127_4403520_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000008495 207.0
HKD3_k127_4403520_4 PFAM TatD-related deoxyribonuclease K07049 - - 0.00000000000000000000000000000000000000000000000000000004391 201.0
HKD3_k127_4403520_5 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000002195 149.0
HKD3_k127_4403520_6 - - - - 0.000000000000000000000000000000000002586 141.0
HKD3_k127_4403520_7 - - - - 0.000000000000000000000000000000001079 132.0
HKD3_k127_4403520_8 Protein of unknown function (DUF2283) - - - 0.000000002439 61.0
HKD3_k127_4403520_9 Domain of unknown function (DUF4258) - - - 0.00000002264 59.0
HKD3_k127_4414537_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 491.0
HKD3_k127_4414537_1 Belongs to the UPF0200 family - - - 0.000000000000000000000000000000000000000000000000000000002691 205.0
HKD3_k127_4414537_2 adenyl ribonucleotide binding - - - 0.0000000162 59.0
HKD3_k127_4414537_3 - - - - 0.0007259 45.0
HKD3_k127_442735_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 360.0
HKD3_k127_442735_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 354.0
HKD3_k127_442735_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000003594 201.0
HKD3_k127_442735_3 Transposase - - - 0.00000000421 60.0
HKD3_k127_4478169_0 DNA methylase K00590 - 2.1.1.113 0.00000000000000000002017 96.0
HKD3_k127_4478169_1 TIGRFAM CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00005221 53.0
HKD3_k127_4514736_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 295.0
HKD3_k127_4514736_1 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002509 285.0
HKD3_k127_4514736_2 phosphoserine phosphatase activity K05518,K07315 - 3.1.3.3 0.000000000000000000000000000000000003432 144.0
HKD3_k127_4514736_3 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K17752 - 2.7.11.1 0.0000000000000000000000000000000009572 133.0
HKD3_k127_4543293_0 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 312.0
HKD3_k127_4543293_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000002106 188.0
HKD3_k127_4543293_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000001179 91.0
HKD3_k127_4543293_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000377 70.0
HKD3_k127_4543293_4 Mo-molybdopterin cofactor metabolic process - - - 0.00000003778 56.0
HKD3_k127_4543293_5 Winged helix-turn-helix - - - 0.0001283 47.0
HKD3_k127_4545406_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 551.0
HKD3_k127_4545406_1 Transcriptional regulator - - - 0.0000000000000000000000000001313 124.0
HKD3_k127_4545406_2 methyltransferase activity - - - 0.0000000000000000000000000007735 117.0
HKD3_k127_4545406_3 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.0000000000000000000003123 97.0
HKD3_k127_4552576_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.333e-302 938.0
HKD3_k127_4552576_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 545.0
HKD3_k127_4552576_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 400.0
HKD3_k127_4552576_3 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 372.0
HKD3_k127_4552576_4 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 349.0
HKD3_k127_4552576_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000001733 268.0
HKD3_k127_4552576_6 PFAM TfuA domain protein, core - - - 0.00000000000000000000000000000000000000000000000000000000000000000001344 240.0
HKD3_k127_4552576_7 PIN domain K07065 - - 0.000000000000000000000001247 108.0
HKD3_k127_4552576_8 SigmaK-factor processing regulatory protein BofA - - - 0.000000000379 63.0
HKD3_k127_4589470_0 Metallo-beta-lactamase superfamily K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 353.0
HKD3_k127_4589470_1 PFAM Thioredoxin K03671 - - 0.0000000000000000000000000000001428 126.0
HKD3_k127_46013_0 - K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 300.0
HKD3_k127_46013_1 Thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000003604 221.0
HKD3_k127_46013_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000001264 149.0
HKD3_k127_46013_3 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000001262 123.0
HKD3_k127_46013_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000006907 86.0
HKD3_k127_46013_5 peptidase - - - 0.00000000007268 62.0
HKD3_k127_464834_0 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 364.0
HKD3_k127_464834_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001114 266.0
HKD3_k127_464834_2 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.0000000000000000000000000000000000000000000000000000002432 205.0
HKD3_k127_464834_3 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000000000000002681 171.0
HKD3_k127_4688426_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000005713 252.0
HKD3_k127_4688426_1 TIGRFAM formylmethanofuran dehydrogenase subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000001347 181.0
HKD3_k127_4688426_2 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.0000000000000000000000000000000000000000002843 160.0
HKD3_k127_4688426_3 Protein of unknown function (DUF356) K09727 - - 0.0000000000000000000000000000007082 126.0
HKD3_k127_4710252_0 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 368.0
HKD3_k127_4710252_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 329.0
HKD3_k127_4710252_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000002014 193.0
HKD3_k127_4710252_3 Family of unknown function (DUF5371) - - - 0.00000000000000004234 82.0
HKD3_k127_4710252_4 Pfam:DUF1628 - - - 0.00000000000006282 75.0
HKD3_k127_4710252_6 COG3316 Transposase and inactivated derivatives - - - 0.0000002859 51.0
HKD3_k127_4710252_7 Family of unknown function (DUF5371) - - - 0.000002343 51.0
HKD3_k127_4736_0 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 482.0
HKD3_k127_4736_1 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000001273 166.0
HKD3_k127_4736_2 Belongs to the peptidase S8 family - - - 0.0000000000000000001342 100.0
HKD3_k127_4736_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000005419 57.0
HKD3_k127_4736_4 TIGRFAM transcriptional regulator, AbrB family - - - 0.00000006915 55.0
HKD3_k127_4753923_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 367.0
HKD3_k127_4753923_1 Putative Fe-S cluster - - - 0.0000000000000000000000008695 107.0
HKD3_k127_4753923_2 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000008735 102.0
HKD3_k127_4811526_0 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000002755 239.0
HKD3_k127_4834506_0 PFAM Radical SAM domain protein K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 561.0
HKD3_k127_4834506_1 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006751 451.0
HKD3_k127_4834506_2 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000003585 218.0
HKD3_k127_4834506_3 PFAM Patatin K07001 - - 0.0000000000000000000000001779 107.0
HKD3_k127_4834506_4 Cytochrome b5-like Heme/Steroid binding domain - - - 0.00000000004536 63.0
HKD3_k127_4834506_5 Patatin-like phospholipase K07001 - - 0.0000001897 53.0
HKD3_k127_4834506_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000166 49.0
HKD3_k127_4846328_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 449.0
HKD3_k127_4846328_1 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000001294 188.0
HKD3_k127_4846328_2 - - - - 0.000000000000001203 78.0
HKD3_k127_485123_0 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 298.0
HKD3_k127_485123_1 COG0785 Cytochrome c biogenesis protein - - - 0.000000000000000000000000000000000000000000000001437 183.0
HKD3_k127_485123_2 - - - - 0.0000000000000000000000001995 111.0
HKD3_k127_485123_3 protein related to C-terminal domain of eukaryotic chaperone, SACSIN - - - 0.0000002191 57.0
HKD3_k127_485123_4 Nucleotidyltransferase domain - - - 0.000003178 56.0
HKD3_k127_485123_5 Phage integrase family - - - 0.0002564 48.0
HKD3_k127_4866404_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 281.0
HKD3_k127_4866404_1 extracellular matrix structural constituent - - - 0.0000000000000000001292 102.0
HKD3_k127_4866404_2 MacB-like periplasmic core domain K09808 - - 0.0000000000001001 82.0
HKD3_k127_4869062_0 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 583.0
HKD3_k127_4869062_1 malic enzyme K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 511.0
HKD3_k127_4869062_2 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008508 511.0
HKD3_k127_4869062_3 KaiC K07331 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 302.0
HKD3_k127_4869062_4 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000001776 234.0
HKD3_k127_4869062_5 transmembrane signaling receptor activity K02660,K03406,K03776,K11525 - - 0.000000000000000000000000000000000000000000000000000000000000004223 222.0
HKD3_k127_4869062_6 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000003161 238.0
HKD3_k127_4869062_7 Transcription factor zinc-finger - - - 0.000000000000002405 84.0
HKD3_k127_4869062_8 SPTR PilT protein domain protein - - - 0.00004934 48.0
HKD3_k127_4871678_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.029e-255 798.0
HKD3_k127_4871678_1 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001403 272.0
HKD3_k127_4871678_2 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000009363 258.0
HKD3_k127_4871678_3 phosphate transporter K16331 - - 0.00000000000000000000000000000000000000000000000000000000000000005752 234.0
HKD3_k127_4871678_4 PFAM PRC-barrel domain - - - 0.0000000000000000000000000002593 117.0
HKD3_k127_4891244_0 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 527.0
HKD3_k127_4891244_1 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000003743 222.0
HKD3_k127_4891244_2 PFAM Transposase DDE domain - - - 0.000000000000000000000000000000000001161 143.0
HKD3_k127_4891244_3 Transposase K07494,K07499 - - 0.000009884 51.0
HKD3_k127_4893597_0 Cytochrome b(N-terminal)/b6/petB K03887 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003842 243.0
HKD3_k127_4893597_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000001417 212.0
HKD3_k127_4893597_2 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000007395 199.0
HKD3_k127_4893597_3 Rieske 2Fe-2S - - - 0.0000000000000000000008861 101.0
HKD3_k127_4893597_4 Cytochrome b subunit of the bc complex K02637 - - 0.00000000000138 74.0
HKD3_k127_4893597_5 Cytochrome c554 and c-prime K03620 - - 0.00000000006437 73.0
HKD3_k127_4893597_7 denitrification pathway - - - 0.000000002566 68.0
HKD3_k127_4893597_8 RimK-like ATP-grasp domain - - - 0.00009551 44.0
HKD3_k127_4902472_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005504 544.0
HKD3_k127_4902472_1 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 319.0
HKD3_k127_4902472_2 KR domain K00023 - 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000008122 269.0
HKD3_k127_4902472_3 PHB de-polymerase C-terminus K03821 - - 0.000000000000000000000000000000000000000000000000000000000000008392 221.0
HKD3_k127_4902472_4 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000002739 198.0
HKD3_k127_4902472_5 membrane - - - 0.000000000001025 81.0
HKD3_k127_4904049_0 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000547 199.0
HKD3_k127_4904049_1 peptidyl-tyrosine sulfation K00525,K01768 - 1.17.4.1,4.6.1.1 0.000000000000000000000000000000000001762 145.0
HKD3_k127_4904049_2 - - - - 0.0000000000000000000008251 103.0
HKD3_k127_4904049_3 - - - - 0.000000000000000002939 88.0
HKD3_k127_4912436_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 4.305e-310 972.0
HKD3_k127_4912436_1 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 321.0
HKD3_k127_4912436_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000006642 93.0
HKD3_k127_4912436_3 DEAD DEAH box helicase domain protein K03724 - - 0.000000002824 57.0
HKD3_k127_4939677_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 572.0
HKD3_k127_4939677_1 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 570.0
HKD3_k127_4939677_2 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 353.0
HKD3_k127_4939677_3 Helix-turn-helix domain protein K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001084 283.0
HKD3_k127_4939677_4 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000000000000000000000000000000008463 207.0
HKD3_k127_4939677_5 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000000001494 189.0
HKD3_k127_4939677_6 - - - - 0.00000000000000000001586 104.0
HKD3_k127_4939677_7 CARDB - - - 0.00000004773 65.0
HKD3_k127_4939677_8 extracellular matrix structural constituent - - - 0.0000004238 58.0
HKD3_k127_4940972_0 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 357.0
HKD3_k127_4940972_1 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001034 247.0
HKD3_k127_4940972_2 PFAM PilT protein domain protein - - - 0.0000000000000000000000009479 108.0
HKD3_k127_4940972_3 Periplasmic copper-binding protein (NosD) - - - 0.000000000000001572 85.0
HKD3_k127_4940972_4 TIGRFAM transcriptional regulator, AbrB family - - - 0.00000002322 58.0
HKD3_k127_4940972_5 - - - - 0.0008175 45.0
HKD3_k127_4948113_0 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 550.0
HKD3_k127_4948113_1 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 423.0
HKD3_k127_4948113_2 STAS domain K17763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001641 247.0
HKD3_k127_4948113_3 PFAM Cytochrome b(N-terminal) b6 petB - - - 0.00000000000000000000000000000000000000001226 164.0
HKD3_k127_4948113_4 Nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000001579 150.0
HKD3_k127_4948113_5 - - - - 0.00000000000000000000000000000002104 143.0
HKD3_k127_4948113_6 Cytochrome c554 and c-prime K03620 - - 0.000000000000000000000000001843 123.0
HKD3_k127_4948113_7 PFAM Sulphate transporter antisigma-factor antagonist STAS K17762 - - 0.00000000000000000000000001703 112.0
HKD3_k127_4948113_8 Belongs to the P(II) protein family K02589 - - 0.000000000000001956 77.0
HKD3_k127_4977535_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 434.0
HKD3_k127_4977535_1 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 0.0000000000000000000000000000000000000000000000000000000001564 205.0
HKD3_k127_4977535_2 Short C-terminal domain K08982 - - 0.0000000000001616 72.0
HKD3_k127_4977535_3 - - - - 0.000000002886 62.0
HKD3_k127_4977535_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0009201 45.0
HKD3_k127_4981882_0 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 445.0
HKD3_k127_4981882_1 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 296.0
HKD3_k127_4981882_2 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000001845 160.0
HKD3_k127_4981882_3 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000002377 121.0
HKD3_k127_4981882_4 PFAM Peptidase S24 S26A S26B, conserved region K13280 - 3.4.21.89 0.00000000000000000000007622 109.0
HKD3_k127_4981882_5 - - - - 0.00000000000000000002999 98.0
HKD3_k127_4981882_6 - - - - 0.0000000000000000003063 101.0
HKD3_k127_4981882_7 - - - - 0.0000000976 57.0
HKD3_k127_4981882_8 - - - - 0.0000001781 64.0
HKD3_k127_4981882_9 AAA domain K02450 - - 0.0001122 53.0
HKD3_k127_4991175_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.001e-224 704.0
HKD3_k127_4991175_1 electron transfer activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 522.0
HKD3_k127_4991175_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 479.0
HKD3_k127_4991175_3 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002286 286.0
HKD3_k127_4991175_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000002938 138.0
HKD3_k127_4991175_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000215 115.0
HKD3_k127_4991175_6 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03673 GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096 - 0.000000000000002034 85.0
HKD3_k127_4993173_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 554.0
HKD3_k127_4993173_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 329.0
HKD3_k127_4993173_2 phosphate transport system permease protein K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 327.0
HKD3_k127_4993173_3 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000001757 229.0
HKD3_k127_4993173_4 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000001215 200.0
HKD3_k127_4993173_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036,K02068,K06857 - 3.6.3.27,3.6.3.55 0.000000000000000000000000000000000000001371 151.0
HKD3_k127_4993173_6 ABC-type phosphate transport system, periplasmic component K02040 - - 0.00000000000000000001138 97.0
HKD3_k127_5022918_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 443.0
HKD3_k127_5022918_1 Membrane protein, UPF0016 and UPF0016 domain-containing - - - 0.000000000000000000000000000000000000000001797 162.0
HKD3_k127_5022918_2 Family of unknown function (DUF5402) - - - 0.0000000000000000000000000000000000000000489 155.0
HKD3_k127_5022918_3 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000001706 143.0
HKD3_k127_5022918_4 Belongs to the WrbA family K03809 - 1.6.5.2 0.0000001181 54.0
HKD3_k127_5032726_0 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 413.0
HKD3_k127_5032726_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 346.0
HKD3_k127_5032726_10 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000635 172.0
HKD3_k127_5032726_11 zinc finger - - - 0.000000000000000000000000000001137 128.0
HKD3_k127_5032726_12 - - - - 0.000000000000000000000001302 111.0
HKD3_k127_5032726_13 Cna B domain protein - - - 0.00000000001663 75.0
HKD3_k127_5032726_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 320.0
HKD3_k127_5032726_3 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000012 285.0
HKD3_k127_5032726_4 Lon protease (S16) C-terminal proteolytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001563 276.0
HKD3_k127_5032726_5 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005399 275.0
HKD3_k127_5032726_6 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000005422 271.0
HKD3_k127_5032726_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000004342 188.0
HKD3_k127_5032726_8 - - - - 0.00000000000000000000000000000000000000000000000002061 192.0
HKD3_k127_5032726_9 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.0000000000000000000000000000000000000000000002639 179.0
HKD3_k127_5055991_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 355.0
HKD3_k127_5055991_1 by modhmm K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000003708 201.0
HKD3_k127_5055991_2 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000001132 141.0
HKD3_k127_5055991_3 - - - - 0.00000000000000000000001471 108.0
HKD3_k127_5055991_6 amidohydrolase - - - 0.0000000000000001253 81.0
HKD3_k127_5061455_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 1.229e-204 655.0
HKD3_k127_5061455_1 Oxidoreductase family, C-terminal alpha/beta domain K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000001219 241.0
HKD3_k127_5061455_2 - - - - 0.0000000000000000009324 87.0
HKD3_k127_5063015_0 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 430.0
HKD3_k127_5063015_1 3-hydroxyacyl-CoA dehydrogenase K00074,K01782 - 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 408.0
HKD3_k127_5063015_2 Oxidoreductase K00313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 403.0
HKD3_k127_5063015_3 PFAM ATP-NAD AcoX kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 325.0
HKD3_k127_5063015_4 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 321.0
HKD3_k127_5063015_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001259 259.0
HKD3_k127_5063015_6 Electron transfer flavoprotein domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000001734 246.0
HKD3_k127_5063015_7 electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000005446 171.0
HKD3_k127_5063015_8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000009762 140.0
HKD3_k127_5063015_9 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03855 - - 0.000000000000000000000000841 107.0
HKD3_k127_5091272_0 PFAM peptidase U32 K08303 - - 3.454e-213 686.0
HKD3_k127_5091272_1 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 400.0
HKD3_k127_5091272_2 COG0500 SAM-dependent methyltransferases K17462 - - 0.000000000000000000000000000000000000000000000000000000000000000000003034 242.0
HKD3_k127_5091272_3 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001133 221.0
HKD3_k127_5091272_4 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000004774 222.0
HKD3_k127_5091272_5 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000000000000002055 171.0
HKD3_k127_5091272_6 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000009862 148.0
HKD3_k127_5091272_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000003551 100.0
HKD3_k127_5091272_8 chorismate mutase K04782 - 4.2.99.21 0.000000000000000000009795 94.0
HKD3_k127_5098248_0 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000006856 201.0
HKD3_k127_5098248_1 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000004728 147.0
HKD3_k127_5098248_2 von Willebrand factor, type A - - - 0.0000000000000000001404 98.0
HKD3_k127_5102381_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.346e-295 917.0
HKD3_k127_5102381_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 531.0
HKD3_k127_5102381_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 442.0
HKD3_k127_5102381_3 - - - - 0.000000000000000000000000000000000000000000001043 174.0
HKD3_k127_5102381_4 Matrixin - - - 0.00000000000000000000000000000000000000009386 161.0
HKD3_k127_5102381_5 - - - - 0.00000000000002491 84.0
HKD3_k127_5102381_6 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000000002913 62.0
HKD3_k127_5113952_0 PFAM ABC transporter K00400 - - 5.876e-239 749.0
HKD3_k127_5113952_1 PFAM ATPase, BadF BadG BcrA BcrD type - - - 3.844e-196 621.0
HKD3_k127_5113952_2 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 525.0
HKD3_k127_5113952_3 methanogenesis marker protein 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 386.0
HKD3_k127_5113952_4 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000008152 213.0
HKD3_k127_5113952_5 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000000001984 151.0
HKD3_k127_5113952_6 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000415 135.0
HKD3_k127_5121019_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 609.0
HKD3_k127_5121019_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703,K16792 - 4.2.1.114,4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000006485 265.0
HKD3_k127_5121019_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000001384 233.0
HKD3_k127_5121019_3 Nitroreductase family - - - 0.00000000000000000000000000000003777 131.0
HKD3_k127_5121019_4 sulfur carrier activity K00549,K04085,K04487,K08363 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.14,2.8.1.7 0.00000000000000000008906 91.0
HKD3_k127_5145376_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000732 276.0
HKD3_k127_5145376_1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002684 298.0
HKD3_k127_5145376_2 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002423 266.0
HKD3_k127_5145376_3 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000000002069 216.0
HKD3_k127_5145376_4 Protein of unknown function (DUF835) K01937,K02488 - 2.7.7.65,6.3.4.2 0.00000000000000000000000000000000000003776 153.0
HKD3_k127_5145376_5 CHASE - - - 0.0000000000000000000000000001504 118.0
HKD3_k127_5145376_6 response regulator, receiver K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000001391 111.0
HKD3_k127_5145376_7 protein contain chitin-binding domain type 3 K01183 - 3.2.1.14 0.000000002357 68.0
HKD3_k127_5167979_0 plastoquinone (Complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 619.0
HKD3_k127_5167979_1 Formate hydrogenlyase subunit 4 K12138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 339.0
HKD3_k127_5167979_2 Hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000001962 183.0
HKD3_k127_5167979_3 subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05568 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.000000000000000000000000002006 117.0
HKD3_k127_5192519_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 514.0
HKD3_k127_5192519_1 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 342.0
HKD3_k127_5192519_2 - - - - 0.000000000000000000000000000000000007169 143.0
HKD3_k127_5217545_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 500.0
HKD3_k127_5217545_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 331.0
HKD3_k127_5217545_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 289.0
HKD3_k127_5217545_3 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002683 289.0
HKD3_k127_5217545_4 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000002055 211.0
HKD3_k127_5222926_0 PFAM type II secretion system protein E K07332 - - 7.832e-243 777.0
HKD3_k127_5222926_1 type II secretion system protein K07333 - - 2.14e-232 736.0
HKD3_k127_5222926_2 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000002225 182.0
HKD3_k127_5222926_3 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000001375 163.0
HKD3_k127_5222926_4 Belongs to the peptidase S16 family K06870 - - 0.0000000000000182 83.0
HKD3_k127_5224538_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1199.0
HKD3_k127_5224538_1 denitrification pathway - - - 0.0000000000000000000000000000000000000000000005297 175.0
HKD3_k127_5224538_2 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000000000005269 157.0
HKD3_k127_5224538_3 denitrification pathway - - - 0.000000000000000000000000000000004766 140.0
HKD3_k127_5224538_4 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000004425 121.0
HKD3_k127_5226497_0 Nitrogenase component 1 type Oxidoreductase K02586 - 1.18.6.1 7.367e-226 710.0
HKD3_k127_5226497_1 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008055 515.0
HKD3_k127_5226497_2 PFAM 2-hydroxyglutaryl-CoA dehydratase D-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 500.0
HKD3_k127_5226497_3 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 420.0
HKD3_k127_5226497_4 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000007131 243.0
HKD3_k127_5226497_5 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000001689 113.0
HKD3_k127_5236520_0 Cytidylyltransferase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 547.0
HKD3_k127_5236520_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 535.0
HKD3_k127_5236520_2 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 370.0
HKD3_k127_5236520_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000001691 242.0
HKD3_k127_5236520_4 SIS domain - - - 0.00000000000000000000000000000000000000000001308 169.0
HKD3_k127_5236520_5 Methyltransferase domain - - - 0.000000000000000000000000000000000388 141.0
HKD3_k127_5236520_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000002465 131.0
HKD3_k127_5236520_7 Tetratricopeptide repeat - - - 0.00000000000428 78.0
HKD3_k127_5250922_0 Ferrous iron transport protein B K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 473.0
HKD3_k127_5250922_1 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007587 312.0
HKD3_k127_5250922_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000004212 220.0
HKD3_k127_5250922_3 Iron permease FTR1 family K07243 - - 0.000000000000000000000000000000000000000000000000000000000000005735 226.0
HKD3_k127_5250922_4 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000009656 184.0
HKD3_k127_5250922_5 Methyl-coenzyme M reductase operon protein D K03422 - - 0.00000000000000000000000000000000000000001454 159.0
HKD3_k127_5260875_0 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 424.0
HKD3_k127_5260875_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 406.0
HKD3_k127_5260875_2 RmlD substrate binding domain K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000002866 243.0
HKD3_k127_5260875_3 dTDP-4-dehydrorhamnose 3,5-epimerase activity K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000001502 224.0
HKD3_k127_5260875_4 Bacterial Ig-like domain 2 - - - 0.00000000000000000001384 108.0
HKD3_k127_5260875_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000002206 104.0
HKD3_k127_5260875_6 Transposase and inactivated derivatives - - - 0.0000003712 57.0
HKD3_k127_5291792_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 527.0
HKD3_k127_5291792_1 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007217 435.0
HKD3_k127_5291792_2 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005539 279.0
HKD3_k127_5291792_3 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000001669 171.0
HKD3_k127_5291792_4 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000001448 124.0
HKD3_k127_5291792_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000008898 110.0
HKD3_k127_5291792_6 nucleotidyltransferase activity K07076 - - 0.0001792 48.0
HKD3_k127_5303639_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 7.692e-221 692.0
HKD3_k127_5303639_1 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 531.0
HKD3_k127_5303639_2 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 454.0
HKD3_k127_5303639_3 CheR methyltransferase, SAM binding domain K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000008156 258.0
HKD3_k127_5303639_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000002319 192.0
HKD3_k127_5303639_5 PFAM DsrE family protein K06039,K07235 - - 0.00000000000000000000000000000000000000000006402 164.0
HKD3_k127_5303639_6 Protein of unknown function (DUF3467) - - - 0.00005159 46.0
HKD3_k127_5306486_0 FAD dependent oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 537.0
HKD3_k127_5306486_1 Conserved hypothetical protein (DUF2461) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 292.0
HKD3_k127_5306486_2 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004077 276.0
HKD3_k127_5306486_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009838 231.0
HKD3_k127_5306486_4 WHG domain - - - 0.00000000000000000000000000000000000000000000000000000000134 207.0
HKD3_k127_5306486_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000006114 141.0
HKD3_k127_5306486_6 NAD(P)H dehydrogenase (quinone) activity - - - 0.000000000000000000000000000000001289 136.0
HKD3_k127_5306486_7 PFAM Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain - - - 0.000000000000000000000000001058 119.0
HKD3_k127_5306486_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000001105 79.0
HKD3_k127_5347028_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.58e-196 620.0
HKD3_k127_5347028_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000008958 224.0
HKD3_k127_5347028_2 ABC-type transport system involved in cytochrome c biogenesis permease component K02195 - - 0.00000000000000000000000000000000000000264 157.0
HKD3_k127_5347028_3 Winged helix-turn-helix - - - 0.00002072 49.0
HKD3_k127_5347028_4 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00005496 50.0
HKD3_k127_5347028_5 - - - - 0.0003843 49.0
HKD3_k127_5362055_0 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 1.099e-222 701.0
HKD3_k127_5362055_1 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 476.0
HKD3_k127_5362055_2 Putative transposase DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 392.0
HKD3_k127_5362055_3 Winged helix DNA-binding domain - - - 0.0006972 44.0
HKD3_k127_5383908_0 Belongs to the UPF0282 family K07022 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 319.0
HKD3_k127_5383908_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 293.0
HKD3_k127_5383908_2 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000003969 228.0
HKD3_k127_5383908_3 Putative ATP-dependant zinc protease - - - 0.0000000000000000000000000000000000000000004244 163.0
HKD3_k127_5383908_4 - - - - 0.000000000000004102 78.0
HKD3_k127_5384853_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 2.9e-224 712.0
HKD3_k127_5384853_1 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 351.0
HKD3_k127_5384853_2 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000002432 233.0
HKD3_k127_5384853_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000002551 185.0
HKD3_k127_5384853_4 Peptidase M10A and M12B matrixin and adamalysin - - - 0.0000000000000000000000000000000006881 137.0
HKD3_k127_5384853_5 Peptidase domain protein - - - 0.0000000000000000002572 87.0
HKD3_k127_5384853_6 Peptidase domain protein - - - 0.00000000000001676 76.0
HKD3_k127_5396764_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 5.37e-206 650.0
HKD3_k127_5396764_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000001127 249.0
HKD3_k127_5396764_2 PFAM Cytochrome c assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000004997 215.0
HKD3_k127_5396764_3 Radical SAM - - - 0.00000000000000000000000000000000000000000001526 169.0
HKD3_k127_5396764_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000004406 132.0
HKD3_k127_5465626_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 422.0
HKD3_k127_5465626_1 V4R K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000003616 228.0
HKD3_k127_5465626_2 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000006703 119.0
HKD3_k127_5465626_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000001509 105.0
HKD3_k127_5465626_4 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.000000000000008306 76.0
HKD3_k127_5520057_0 ATPases associated with a variety of cellular activities K00400 - - 2.738e-196 628.0
HKD3_k127_5520057_1 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 333.0
HKD3_k127_5520057_2 membrane-associated protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001528 275.0
HKD3_k127_5520057_3 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000004166 241.0
HKD3_k127_5520057_4 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000002524 221.0
HKD3_k127_5520057_5 - - - - 0.0000000000000000000000000000001321 138.0
HKD3_k127_5520057_6 - - - - 0.000001418 56.0
HKD3_k127_5555008_0 S-layer protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 610.0
HKD3_k127_5555008_1 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000003239 117.0
HKD3_k127_5555008_2 - - - - 0.0000003309 61.0
HKD3_k127_5555008_3 Belongs to the peptidase C1 family - - - 0.00007125 55.0
HKD3_k127_5589133_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1222.0
HKD3_k127_5589133_1 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
HKD3_k127_5589133_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 297.0
HKD3_k127_5589133_3 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000002208 216.0
HKD3_k127_5589133_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000129 178.0
HKD3_k127_5589133_5 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00179 - 1.2.7.8 0.000004376 52.0
HKD3_k127_5589135_0 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 371.0
HKD3_k127_5589135_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000002739 240.0
HKD3_k127_5589135_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.00000000000000000000000000000000000000000000000000000005804 198.0
HKD3_k127_5589135_3 eRF1 domain 2 - - - 0.00000000000000000000000000000000000000000000127 177.0
HKD3_k127_5589135_4 binds to the 23S rRNA K02921 - - 0.000000000000000000000003112 105.0
HKD3_k127_5589135_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000000137 88.0
HKD3_k127_5589135_6 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000004645 68.0
HKD3_k127_5612843_0 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 420.0
HKD3_k127_5612843_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 362.0
HKD3_k127_5612843_2 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 294.0
HKD3_k127_5612843_3 Phospholipid methyltransferase - - - 0.0000000000000000000001505 104.0
HKD3_k127_5612843_4 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00161 - 1.2.4.1 0.0000000000144 67.0
HKD3_k127_5657617_0 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 331.0
HKD3_k127_5657617_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000001002 238.0
HKD3_k127_5657617_10 - - - - 0.00000000000715 76.0
HKD3_k127_5657617_11 - - - - 0.00000000622 66.0
HKD3_k127_5657617_12 - - - - 0.00000001185 64.0
HKD3_k127_5657617_2 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.00000000000000000000000000000000000000000000000007104 180.0
HKD3_k127_5657617_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000003865 179.0
HKD3_k127_5657617_4 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000001822 118.0
HKD3_k127_5657617_5 Binds to the 23S rRNA K02896 - - 0.00000000000000000000000045 105.0
HKD3_k127_5657617_6 - - - - 0.0000000000000000000164 100.0
HKD3_k127_5657617_7 PFAM Peptidase S24 S26A S26B, conserved region K13280 - 3.4.21.89 0.00000000000000000003414 99.0
HKD3_k127_5657617_8 - - - - 0.0000000000000000007182 99.0
HKD3_k127_5657617_9 - - - - 0.000000000000007149 81.0
HKD3_k127_5689319_0 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 513.0
HKD3_k127_5689319_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 434.0
HKD3_k127_5689319_10 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000003192 182.0
HKD3_k127_5689319_11 - - - - 0.000000000000000000000000000000000000000343 154.0
HKD3_k127_5689319_12 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000000000000000004084 134.0
HKD3_k127_5689319_13 cheY-homologous receiver domain K07668 - - 0.00000000000000000000000000007566 117.0
HKD3_k127_5689319_2 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006309 423.0
HKD3_k127_5689319_3 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007393 395.0
HKD3_k127_5689319_4 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006721 400.0
HKD3_k127_5689319_5 ATPase, AAA superfamily K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 385.0
HKD3_k127_5689319_6 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 350.0
HKD3_k127_5689319_7 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 316.0
HKD3_k127_5689319_8 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003624 281.0
HKD3_k127_5689319_9 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000005038 230.0
HKD3_k127_5701162_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 436.0
HKD3_k127_5701162_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 310.0
HKD3_k127_5701162_2 COG0095 Lipoate-protein ligase A K03800 GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681 6.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001526 275.0
HKD3_k127_5701162_3 alkyl hydroperoxide reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007377 231.0
HKD3_k127_5701162_4 Rubredoxin - - - 0.00000000000000000001811 91.0
HKD3_k127_5701162_5 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.0000000002467 64.0
HKD3_k127_5707849_0 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000006313 218.0
HKD3_k127_5707849_1 Protein of unknown function (DUF3343) - - - 0.0000000000000000000000000000000003447 139.0
HKD3_k127_5707849_2 Sulphur transport K07112 - - 0.00000000000000000000001386 110.0
HKD3_k127_5707849_3 - - - - 0.00000000000000000000001431 106.0
HKD3_k127_5707849_4 Transposase DDE domain - - - 0.0000000003967 63.0
HKD3_k127_5707849_5 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.0001659 51.0
HKD3_k127_5761330_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004881 314.0
HKD3_k127_5761330_1 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 302.0
HKD3_k127_5761330_2 RNA ligase K07468 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 304.0
HKD3_k127_5761330_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007271 269.0
HKD3_k127_5761330_4 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002678 260.0
HKD3_k127_5761330_5 signal transduction protein with CBS domains - - - 0.0000000000000000000000000000000000001949 147.0
HKD3_k127_57721_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006809 416.0
HKD3_k127_57721_1 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 389.0
HKD3_k127_57721_10 Thioredoxin domain - - - 0.000000000000000000004181 98.0
HKD3_k127_57721_11 nucleic acid-binding protein, contains PIN domain K07065 - - 0.00000000000000000005346 95.0
HKD3_k127_57721_12 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000001931 94.0
HKD3_k127_57721_13 Family of unknown function (DUF5371) - - - 0.000000000000000005855 85.0
HKD3_k127_57721_14 Uncharacterized metal-binding protein (DUF2227) - - - 0.000000000000000009585 88.0
HKD3_k127_57721_15 COG3316 Transposase and inactivated derivatives K07498 - - 0.00000000000002491 80.0
HKD3_k127_57721_16 - - - - 0.00000000001001 66.0
HKD3_k127_57721_17 - - - - 0.000000002296 62.0
HKD3_k127_57721_18 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.0000002631 55.0
HKD3_k127_57721_2 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 375.0
HKD3_k127_57721_20 Methyltransferase domain - - - 0.0007044 46.0
HKD3_k127_57721_3 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 342.0
HKD3_k127_57721_4 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 297.0
HKD3_k127_57721_5 - - - - 0.000000000000000000000000000000000000000000000000000004643 193.0
HKD3_k127_57721_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000001484 183.0
HKD3_k127_57721_7 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000005609 159.0
HKD3_k127_57721_8 - - - - 0.00000000000000000000000000000000005789 151.0
HKD3_k127_57721_9 Belongs to the acylphosphatase family - - - 0.00000000000000000000000000046 121.0
HKD3_k127_581852_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 500.0
HKD3_k127_581852_1 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 479.0
HKD3_k127_581852_10 Belongs to the UPF0235 family K09131 - - 0.000000000000000000002309 96.0
HKD3_k127_581852_11 Methanogenesis marker protein 8 - - - 0.0000000000000000003 87.0
HKD3_k127_581852_12 Bacterial lipoate protein ligase C-terminus K03800 - 6.3.1.20 0.00000000000001809 76.0
HKD3_k127_581852_13 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000009046 70.0
HKD3_k127_581852_14 - - - - 0.0000003848 59.0
HKD3_k127_581852_2 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 359.0
HKD3_k127_581852_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 357.0
HKD3_k127_581852_4 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 297.0
HKD3_k127_581852_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000001266 186.0
HKD3_k127_581852_6 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000002547 177.0
HKD3_k127_581852_7 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000004827 164.0
HKD3_k127_581852_8 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000004986 165.0
HKD3_k127_581852_9 metal ion binding - - - 0.00000000000000000000000000001525 122.0
HKD3_k127_5895620_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1188.0
HKD3_k127_5895620_1 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001097 265.0
HKD3_k127_5896047_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001325 248.0
HKD3_k127_5896047_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000006627 169.0
HKD3_k127_5896047_2 PFAM methyltransferase - - - 0.0000000000000000000000000000001823 136.0
HKD3_k127_5896047_3 Methyltransferase FkbM domain - - - 0.000000000004026 74.0
HKD3_k127_59199_0 flavodoxin nitric oxide synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 560.0
HKD3_k127_59199_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000009155 151.0
HKD3_k127_59199_2 PFAM YHS domain - - - 0.0000000000000000002062 89.0
HKD3_k127_5959801_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 394.0
HKD3_k127_5959801_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 360.0
HKD3_k127_5959801_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 351.0
HKD3_k127_5959801_3 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 306.0
HKD3_k127_5959801_4 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000001826 205.0
HKD3_k127_5959801_5 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000009975 181.0
HKD3_k127_5959801_6 Acylphosphatase K01512 - 3.6.1.7 0.00000000000000000000000000005334 119.0
HKD3_k127_5959801_7 COG1522 Transcriptional regulators - - - 0.000000000000000000000000006039 111.0
HKD3_k127_5959801_8 structural constituent of ribosome K02962 - - 0.00000000000002736 74.0
HKD3_k127_6053028_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 440.0
HKD3_k127_6053028_1 GDP dissociation inhibitor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 428.0
HKD3_k127_6053028_2 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 422.0
HKD3_k127_6053028_3 ribosomal protein S15 K02956 - - 0.000000000000000000000000000000000000000000000001687 177.0
HKD3_k127_6053028_4 - - - - 0.0000000000000000000000000004184 128.0
HKD3_k127_6053028_5 - - - - 0.00000000001332 71.0
HKD3_k127_6053028_6 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.00000000563 60.0
HKD3_k127_6053028_7 - - - - 0.00005825 53.0
HKD3_k127_6055129_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002453 287.0
HKD3_k127_6055129_1 InterPro IPR007367 - - - 0.0000000000000000000000000000001095 126.0
HKD3_k127_6055129_2 - - - - 0.0005298 45.0
HKD3_k127_6061271_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 341.0
HKD3_k127_6061271_1 Flavoprotein K18853 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0042558,GO:0042559,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901283,GO:1901285,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:2001115,GO:2001116,GO:2001117,GO:2001118 1.5.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 289.0
HKD3_k127_6061271_2 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000000000008322 173.0
HKD3_k127_6061271_3 B-block binding subunit of TFIIIC - - - 0.000000000000000000000000005588 113.0
HKD3_k127_6061271_4 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000007338 111.0
HKD3_k127_6061271_5 Cupredoxin-like domain - - - 0.000000000000000000002918 98.0
HKD3_k127_6061271_6 Has ATPase and non-specific DNA-binding activities K07456 - - 0.00000000007315 63.0
HKD3_k127_6074242_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 2.955e-276 857.0
HKD3_k127_6074242_1 DNA methylase K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001565 273.0
HKD3_k127_6074242_3 - - - - 0.0000000000000000001464 89.0
HKD3_k127_6091091_0 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 446.0
HKD3_k127_6091091_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 385.0
HKD3_k127_6091091_10 Possibly the antitoxin component of a type II toxin- antitoxin (TA) system - - - 0.0001541 48.0
HKD3_k127_6091091_2 AAA ATPase domain K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 362.0
HKD3_k127_6091091_3 Radical SAM domain protein K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000003561 267.0
HKD3_k127_6091091_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000009831 211.0
HKD3_k127_6091091_5 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000005013 159.0
HKD3_k127_6091091_6 DNA polymerase beta domain protein region - - - 0.0000000000000000000000000000002688 125.0
HKD3_k127_6091091_7 PIN domain K07065 - - 0.0000000000000005499 79.0
HKD3_k127_6091091_8 dihydromethanopterin reductase activity K00176,K06411,K12527 - 1.2.7.3,1.97.1.9 0.000000000000001316 78.0
HKD3_k127_6091091_9 Contains PIN domain - - - 0.00002085 49.0
HKD3_k127_6106534_0 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 610.0
HKD3_k127_6106534_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 436.0
HKD3_k127_6106534_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000009051 138.0
HKD3_k127_6106534_3 Tautomerase enzyme K01821 - 5.3.2.6 0.0000000000009318 70.0
HKD3_k127_6106534_4 Uncharacterised ArCR, COG2043 - - - 0.00005644 45.0
HKD3_k127_6142476_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 8.751e-285 917.0
HKD3_k127_6142476_1 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 301.0
HKD3_k127_6142476_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000435 261.0
HKD3_k127_6149873_0 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 292.0
HKD3_k127_6149873_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000005932 79.0
HKD3_k127_6149873_2 SpoVT / AbrB like domain - - - 0.0009923 43.0
HKD3_k127_6163538_0 PFAM Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 508.0
HKD3_k127_6163538_1 CcmE K02197 - - 0.00000000000001111 79.0
HKD3_k127_6163538_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000001417 72.0
HKD3_k127_6170129_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 458.0
HKD3_k127_6170129_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000001085 170.0
HKD3_k127_6170129_2 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000299 163.0
HKD3_k127_6170129_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000001637 60.0
HKD3_k127_6174092_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 298.0
HKD3_k127_6174092_1 regulation of methylation-dependent chromatin silencing K07454 - - 0.00000000000000000000000000000000000000000000000000000000005778 216.0
HKD3_k127_6174092_2 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000002493 182.0
HKD3_k127_6174092_3 transmembrane transporter activity K02008 - - 0.0000000000000001372 89.0
HKD3_k127_6179562_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 356.0
HKD3_k127_6179562_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003374 284.0
HKD3_k127_6179562_2 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000002101 211.0
HKD3_k127_6179562_3 PFAM Transposase DDE domain - - - 0.0000000001068 69.0
HKD3_k127_6204131_0 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 560.0
HKD3_k127_6204131_1 general stress protein K06884 - - 0.000000000000000000003328 101.0
HKD3_k127_6204131_2 - - - - 0.00000000000000229 83.0
HKD3_k127_6204131_3 S-layer protein - - - 0.0000108 56.0
HKD3_k127_6215113_0 Protein of unknown function (DUF1464) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002174 274.0
HKD3_k127_6229034_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 598.0
HKD3_k127_6229034_1 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 324.0
HKD3_k127_6236853_0 Pfam:KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001973 262.0
HKD3_k127_6236853_1 Roadblock LC7 family protein K07131 - - 0.00000000000000000000000000000000000000001204 156.0
HKD3_k127_6236853_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000003412 61.0
HKD3_k127_6241010_0 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.0000000000000000000000000000000000000000000000000000000000000000009656 231.0
HKD3_k127_6241010_1 response to oxidative stress K04063 - - 0.00000000000000000000000009068 111.0
HKD3_k127_6251478_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 479.0
HKD3_k127_6251478_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 392.0
HKD3_k127_6251478_2 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 331.0
HKD3_k127_6251478_3 Winged helix-turn-helix - - - 0.00000000001486 68.0
HKD3_k127_6251478_4 Transcriptional regulator - - - 0.00006289 46.0
HKD3_k127_6261168_0 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000001105 272.0
HKD3_k127_6261168_1 Fic/DOC family N-terminal - - - 0.00000000000000000000000000173 114.0
HKD3_k127_6261168_2 nucleotidyltransferase activity K07076 - - 0.00000000000000000000003133 102.0
HKD3_k127_6261168_3 Protein of unknown function (DUF521) K09123 - - 0.00000000000000007001 81.0
HKD3_k127_6261168_4 HEPN domain - - - 0.00000000000001498 77.0
HKD3_k127_6291914_0 Acetyl xylan esterase (AXE1) K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000001764 237.0
HKD3_k127_6291914_1 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000001725 227.0
HKD3_k127_6291914_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000005733 209.0
HKD3_k127_6291914_3 to GB L77117 SP Q58031 PID 1591324 percent identity - - - 0.00000000000000000000000000000000000000000000000004325 183.0
HKD3_k127_6291914_4 - - - - 0.00000000000000000000000000000000000000000000000008302 183.0
HKD3_k127_6291914_5 NADPH-dependent FMN reductase K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000002803 166.0
HKD3_k127_6291914_6 Resolvase, N terminal domain - - - 0.0000000000000006192 84.0
HKD3_k127_6336667_0 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 346.0
HKD3_k127_6336667_1 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000007165 60.0
HKD3_k127_6336667_2 His Kinase A (phosphoacceptor) domain - - - 0.0000006333 59.0
HKD3_k127_6336667_3 - - - - 0.000003815 50.0
HKD3_k127_6348111_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 477.0
HKD3_k127_6359983_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 356.0
HKD3_k127_6359983_1 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000006925 212.0
HKD3_k127_6359983_2 - - - - 0.000000000000000000003625 96.0
HKD3_k127_6367409_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009087 503.0
HKD3_k127_6367409_1 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 400.0
HKD3_k127_6367409_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 310.0
HKD3_k127_6367409_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000228 280.0
HKD3_k127_6367409_4 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000001578 115.0
HKD3_k127_6378337_0 AAA family ATPase, CDC48 subfamily K13525 - - 1.23e-317 987.0
HKD3_k127_6378337_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 3.697e-313 971.0
HKD3_k127_6378337_2 Hsp20/alpha crystallin family K13993 - - 0.000000000001702 73.0
HKD3_k127_6382649_0 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 455.0
HKD3_k127_6382649_1 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 359.0
HKD3_k127_6382649_2 Zn-dependent protease with chaperone function K03799,K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000004847 174.0
HKD3_k127_6382649_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000001593 155.0
HKD3_k127_6382649_5 COG1943 Transposase and inactivated derivatives K07491 - - 0.00000000000000000000004192 104.0
HKD3_k127_6382649_6 Uncharacterized conserved protein (COG2071) K09166 - - 0.000000000000000000001124 104.0
HKD3_k127_6382649_7 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000003071 91.0
HKD3_k127_6382649_8 Domain of unknown function (DUF4258) - - - 0.00000000000000001139 87.0
HKD3_k127_6382649_9 - - - - 0.0000000001426 70.0
HKD3_k127_6384483_0 Cytochrome b subunit of the bc K00412,K02635 - - 0.0000000000000000000000000000000000002565 147.0
HKD3_k127_6384483_1 Rieske [2Fe-2S] domain - - - 0.000000000000000000001657 100.0
HKD3_k127_6384483_2 denitrification pathway - - - 0.00000000004922 74.0
HKD3_k127_6384483_4 Cytochrome c554 and c-prime K03620 - - 0.00000003199 64.0
HKD3_k127_6389292_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 512.0
HKD3_k127_6389292_1 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 421.0
HKD3_k127_6389292_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 386.0
HKD3_k127_6390114_0 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006441 346.0
HKD3_k127_6390114_1 Zn-ribbon containing protein K07163 - - 0.0000000000000000000000000000000000000009999 151.0
HKD3_k127_6390114_2 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000003554 146.0
HKD3_k127_6390114_3 HEPN domain - - - 0.00008055 49.0
HKD3_k127_6402839_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 521.0
HKD3_k127_6402839_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000002211 196.0
HKD3_k127_6402839_2 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000001397 122.0
HKD3_k127_6402839_3 - - - - 0.000000000000001657 81.0
HKD3_k127_6404152_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 7.181e-222 700.0
HKD3_k127_6404152_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000007754 265.0
HKD3_k127_6404152_2 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.0000000000000000000002097 99.0
HKD3_k127_6404152_3 MoaE protein K03635 - 2.8.1.12 0.000000000000000000004393 96.0
HKD3_k127_6419288_0 haloacid dehalogenase-like hydrolase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 405.0
HKD3_k127_6419288_1 PHB de-polymerase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 384.0
HKD3_k127_6419288_2 Rubredoxin - - - 0.000000000000002337 76.0
HKD3_k127_6431136_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 363.0
HKD3_k127_6431136_1 Uncharacterized membrane protein (DUF2298) - - - 0.0000000000000000000000000000000000003864 148.0
HKD3_k127_6431136_2 Large family of predicted nucleotide-binding domains K07064 - - 0.00002547 53.0
HKD3_k127_6432257_0 cheY-homologous receiver domain K07668 - - 0.000000000000000000000000000000000000000000000005862 174.0
HKD3_k127_6432257_1 phosphorelay sensor kinase activity K14986 - 2.7.13.3 0.000000000000000000000000000000000000000007913 177.0
HKD3_k127_6432257_2 ANTAR - - - 0.0000000000000000000000000000003689 143.0
HKD3_k127_6432957_0 Cysteine-rich secretory protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002376 257.0
HKD3_k127_6432957_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000000001905 193.0
HKD3_k127_6432957_2 restriction K01154 - 3.1.21.3 0.00000000000000000000002077 107.0
HKD3_k127_6440309_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001835 281.0
HKD3_k127_6440309_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000001003 219.0
HKD3_k127_6440309_2 Glycosyl transferase family group 2 - - - 0.0000000000000001174 83.0
HKD3_k127_6458145_0 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 389.0
HKD3_k127_6492586_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 446.0
HKD3_k127_6492586_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 384.0
HKD3_k127_6492586_2 Fe-S cluster K04488 - - 0.0000000000000000000000000000000000000000000000000000002673 210.0
HKD3_k127_6492586_3 Domain of unknown function (DUF4143) K07133 - - 0.000000000000000000000000000000000000000000000000002432 199.0
HKD3_k127_6492586_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000002291 178.0
HKD3_k127_6492586_5 PFAM DsrE family protein K07092 GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.00000000000000000000000000000000000000000008811 162.0
HKD3_k127_6492586_6 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000000000000000001225 152.0
HKD3_k127_6492586_7 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000000007529 108.0
HKD3_k127_6492586_8 CAAX protease self-immunity K07052 - - 0.000000005777 59.0
HKD3_k127_6496719_0 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 396.0
HKD3_k127_6496719_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 379.0
HKD3_k127_6496719_2 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000221 285.0
HKD3_k127_6496719_3 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002457 256.0
HKD3_k127_6496719_4 AAA ATPase domain - - - 0.00000000000000000000000000000000001688 144.0
HKD3_k127_6521864_0 KaiC K07331 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001219 257.0
HKD3_k127_6521864_1 PFAM type II secretion system protein E K07332 - - 0.000000000000000000000000000000000000000000000003774 179.0
HKD3_k127_6521864_2 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000004122 147.0
HKD3_k127_6521864_3 Archaebacterial flagellin K07330 - - 0.0000000000000000000000000000001498 128.0
HKD3_k127_6521864_4 Archaeal flagellar protein F K07329 - - 0.0000006769 56.0
HKD3_k127_6525580_0 Elongator protein 3, MiaB family, Radical SAM K09711 - - 0.00000000000000000000000000000000000000000000000000000003056 207.0
HKD3_k127_6525580_1 PQQ-like domain - - - 0.000000001061 71.0
HKD3_k127_6525580_2 Phospholipase_D-nuclease N-terminal - - - 0.00000003327 58.0
HKD3_k127_6534898_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 498.0
HKD3_k127_6534898_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 393.0
HKD3_k127_6534898_10 - - - - 0.00000000000000002118 87.0
HKD3_k127_6534898_11 membrane-associated protein domain - - - 0.00000000007119 74.0
HKD3_k127_6534898_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 321.0
HKD3_k127_6534898_3 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 310.0
HKD3_k127_6534898_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 313.0
HKD3_k127_6534898_5 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 305.0
HKD3_k127_6534898_6 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000009425 238.0
HKD3_k127_6534898_7 methyltransferase - - - 0.0000000000000000000000000000001845 133.0
HKD3_k127_6534898_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000009486 111.0
HKD3_k127_6534898_9 Domain of unknown function (DUF4234) - - - 0.0000000000000000009461 89.0
HKD3_k127_6536160_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 587.0
HKD3_k127_6536160_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 532.0
HKD3_k127_6536160_2 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 362.0
HKD3_k127_6536160_3 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 299.0
HKD3_k127_6536160_4 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001444 258.0
HKD3_k127_6536160_5 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001504 252.0
HKD3_k127_6536160_6 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000005776 247.0
HKD3_k127_6536160_7 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000001287 119.0
HKD3_k127_6536160_8 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.000000000000000001251 91.0
HKD3_k127_6559444_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 406.0
HKD3_k127_6559444_1 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000001992 186.0
HKD3_k127_6559444_2 zinc finger - - - 0.000000000000000000000000000000000000000000000000002068 188.0
HKD3_k127_6559444_3 - - - - 0.0000000000001383 72.0
HKD3_k127_6571266_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 383.0
HKD3_k127_6571266_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 344.0
HKD3_k127_6571266_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009878 277.0
HKD3_k127_6571266_3 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000001091 242.0
HKD3_k127_6571266_4 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000002857 235.0
HKD3_k127_6597183_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 427.0
HKD3_k127_6597183_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007286 347.0
HKD3_k127_6597183_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 299.0
HKD3_k127_6597183_3 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000001893 203.0
HKD3_k127_6597183_4 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000004797 171.0
HKD3_k127_6597183_5 - - - - 0.000000000002266 74.0
HKD3_k127_6597183_6 SMART Elongator protein 3 MiaB NifB - - - 0.000002829 53.0
HKD3_k127_6629415_0 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 306.0
HKD3_k127_6629415_1 PFAM nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000006442 205.0
HKD3_k127_6629415_2 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000006764 195.0
HKD3_k127_6629415_3 Binding-protein-dependent transport system inner membrane component K02050,K15552,K15554 - - 0.000000000000000000000000000000000000000000002807 175.0
HKD3_k127_6629415_4 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000004052 134.0
HKD3_k127_6629415_5 Avidin family - - - 0.0000000000000000000000000002836 118.0
HKD3_k127_6629415_6 ChaB K06197 - - 0.00000000000000000000492 93.0
HKD3_k127_6642869_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1311.0
HKD3_k127_6642869_1 Roadblock LC7 family protein K07131 - - 0.0000000000000000000001039 99.0
HKD3_k127_6650473_0 PHB de-polymerase C-terminus K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 442.0
HKD3_k127_6650473_1 3-alpha-hydroxysteroid dehydrogenase K00038 - 1.1.1.53 0.0000000000000000000608 91.0
HKD3_k127_6650473_2 Poly(R)-hydroxyalkanoic acid synthase class III PhaE subunit - GO:0008150,GO:0008152,GO:0009058,GO:0042618,GO:0042619,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - 0.0000000001096 69.0
HKD3_k127_6650473_3 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.000004671 58.0
HKD3_k127_6661502_0 CoA binding domain K01905 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 473.0
HKD3_k127_6661502_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 407.0
HKD3_k127_6661502_2 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 331.0
HKD3_k127_6661502_3 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000001972 229.0
HKD3_k127_6661502_4 - - - - 0.00000000002167 68.0
HKD3_k127_6677311_0 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000007938 211.0
HKD3_k127_6677311_1 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000000007367 207.0
HKD3_k127_6677311_2 Type II secretion system (T2SS), protein F K07333 - - 0.00000000000000000000000000000000000000000007305 170.0
HKD3_k127_6677311_3 Pfam:Arch_ATPase - - - 0.000000000000000000000000006299 121.0
HKD3_k127_6677311_4 - - - - 0.00000000000000000000000001207 119.0
HKD3_k127_6677311_5 HMGL-like K01649 - 2.3.3.13 0.0003718 44.0
HKD3_k127_6680769_0 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008466 428.0
HKD3_k127_675849_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009512 440.0
HKD3_k127_675849_1 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 382.0
HKD3_k127_675849_2 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000004235 216.0
HKD3_k127_675849_3 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000001482 186.0
HKD3_k127_675849_4 Uncharacterised protein family UPF0058 - - - 0.0000000000000000000000000001866 116.0
HKD3_k127_675849_5 S-layer protein - - - 0.00000000000000000000000000239 124.0
HKD3_k127_6782640_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.685e-302 941.0
HKD3_k127_6782640_1 DNA methylase K00590 - 2.1.1.113 0.00000001594 59.0
HKD3_k127_67913_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 481.0
HKD3_k127_67913_1 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 295.0
HKD3_k127_67913_2 transferase hexapeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
HKD3_k127_67913_3 photosystem II stabilization K02237,K02460 - - 0.00000000000000000000001585 109.0
HKD3_k127_6806867_0 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 372.0
HKD3_k127_6806867_1 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000000000002014 77.0
HKD3_k127_6806867_2 cell wall organization - - - 0.0000006938 56.0
HKD3_k127_6822865_0 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 329.0
HKD3_k127_6822865_1 CGGC - - - 0.000000000000000000000000000000000000000000004704 164.0
HKD3_k127_6822865_2 Domain of unknown function (DUF1858) - - - 0.00000000000000000004018 91.0
HKD3_k127_6822865_3 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000000000009543 91.0
HKD3_k127_683225_0 Has ATPase and non-specific DNA-binding activities K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 593.0
HKD3_k127_683225_1 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000884 158.0
HKD3_k127_683225_2 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000005782 131.0
HKD3_k127_683225_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000002346 119.0
HKD3_k127_683225_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000003038 104.0
HKD3_k127_6838632_0 - - - - 0.00000000000000000000000000001363 119.0
HKD3_k127_6838632_1 - - - - 0.000000000000000000009735 98.0
HKD3_k127_6838632_2 S-layer protein - - - 0.00000000000000334 81.0
HKD3_k127_6849706_0 xylanase chitin deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000000004618 221.0
HKD3_k127_6849706_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000003279 221.0
HKD3_k127_6849706_2 Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - 0.00000000000000000000000000000007142 128.0
HKD3_k127_6849706_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000002926 64.0
HKD3_k127_6855386_0 Molybdopterin oxidoreductase K00201 - 1.2.7.12 8.186e-227 708.0
HKD3_k127_6855386_1 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.00000000000000000000000000000000000000000004699 164.0
HKD3_k127_6855386_2 DNA polymerase beta domain protein region - - - 0.0000000000000000000000000000000000002452 143.0
HKD3_k127_6855386_3 PFAM HEPN domain - - - 0.000000000000000000000000000000003465 132.0
HKD3_k127_6855386_4 GXGXG motif K00202 - 1.2.7.12 0.00000000000000000001047 93.0
HKD3_k127_6879751_0 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000001596 168.0
HKD3_k127_6879751_1 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000367 127.0
HKD3_k127_6881939_0 Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 291.0
HKD3_k127_6881939_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.00000000000000000000000000000000000000000000000000000000001904 212.0
HKD3_k127_6881939_2 flagella protein K07327,K07328 - - 0.000000000000001636 79.0
HKD3_k127_6898632_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 437.0
HKD3_k127_6898632_1 binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 299.0
HKD3_k127_6898632_2 transcriptional regulator, AsnC family - - - 0.000000000000000000000000000000000000000000000000000000000005732 213.0
HKD3_k127_6898632_3 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000000001358 202.0
HKD3_k127_6898632_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000498 187.0
HKD3_k127_6898632_5 SnoaL-like domain - - - 0.000000000000000000000000000001239 124.0
HKD3_k127_6898632_6 Protein of unknown function (DUF3341) - - - 0.00000000000000000004418 95.0
HKD3_k127_6898632_7 PFAM Yip1 domain - - - 0.0000000000000167 80.0
HKD3_k127_6898632_8 Protein of unknown function (DUF3341) - - - 0.000009026 49.0
HKD3_k127_6981061_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 5.264e-196 621.0
HKD3_k127_6981061_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002052 275.0
HKD3_k127_6981061_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000001471 240.0
HKD3_k127_6981061_3 PFAM AIR synthase related protein K07388 - - 0.00000000000000002437 82.0
HKD3_k127_7010544_0 Proton-conducting membrane transporter K22169 - 1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 524.0
HKD3_k127_7010544_1 F420H2 dehydrogenase subunit FpoO K22170 - 1.5.98.3 0.00000000000006101 76.0
HKD3_k127_7010544_2 CcmE K02197 - - 0.00000000005342 68.0
HKD3_k127_7010544_3 Proton-conducting membrane transporter K22168 - 1.5.98.3 0.00000001832 56.0
HKD3_k127_701560_0 carbon starvation protein CstA K06200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005706 363.0
HKD3_k127_701560_1 - - - - 0.0000000000000000000000000005813 115.0
HKD3_k127_701560_2 HEPN domain - - - 0.000000000000000001599 87.0
HKD3_k127_701560_3 - - - - 0.00000000000000001937 92.0
HKD3_k127_701560_4 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000003857 62.0
HKD3_k127_701560_5 ATPases associated with a variety of cellular activities K02003 - - 0.00000000177 59.0
HKD3_k127_7022662_0 COG0464 ATPases of the AAA class K13525 - - 1.186e-295 919.0
HKD3_k127_7022662_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 292.0
HKD3_k127_7022662_2 PFAM PRC-barrel domain - - - 0.0000000000000000000002508 98.0
HKD3_k127_7129858_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 436.0
HKD3_k127_7129858_1 Protein of unknown function (DUF434) - - - 0.0000000000000000000000000000000000000000000008968 174.0
HKD3_k127_7129858_2 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000003885 140.0
HKD3_k127_7129858_3 Nucleotidyltransferase domain K07075 - - 0.00000000000000000000000000000004028 127.0
HKD3_k127_7129858_4 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000007278 55.0
HKD3_k127_7134224_0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 347.0
HKD3_k127_7134224_1 PFAM Extracellular ligand-binding receptor - - - 0.00000000000000000000000000000000000000000001859 167.0
HKD3_k127_7134224_2 cheY-homologous receiver domain - - - 0.0000000000000000000000000001096 118.0
HKD3_k127_7134224_3 PFAM Extracellular ligand-binding receptor - - - 0.00000001197 58.0
HKD3_k127_7144326_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 598.0
HKD3_k127_7144326_1 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 479.0
HKD3_k127_7144326_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 372.0
HKD3_k127_7144326_3 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 309.0
HKD3_k127_7144326_4 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004615 271.0
HKD3_k127_7144326_5 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.0000000000000000000000000000000000000000000000004683 183.0
HKD3_k127_7144326_7 - - - - 0.0000000000004351 76.0
HKD3_k127_7144326_8 R-phenyllactate dehydratase activator - - - 0.0000000000007559 69.0
HKD3_k127_7144326_9 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000001078 52.0
HKD3_k127_7168433_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001422 269.0
HKD3_k127_7168433_1 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003804 254.0
HKD3_k127_7168433_2 cheY-homologous receiver domain K07658 - - 0.00000000000000000000000000000000000000000000000006758 182.0
HKD3_k127_7168433_3 - - - - 0.0000000000000000000000000001194 117.0
HKD3_k127_7168433_4 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000002736 63.0
HKD3_k127_7204988_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 516.0
HKD3_k127_7204988_1 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001252 290.0
HKD3_k127_7204988_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000001195 192.0
HKD3_k127_7204988_3 PFAM PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000000000001387 178.0
HKD3_k127_7204988_4 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000351 83.0
HKD3_k127_7278241_0 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 455.0
HKD3_k127_7278241_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 411.0
HKD3_k127_7278241_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 332.0
HKD3_k127_7278241_3 phosphoribosyltransferase K07100 - - 0.0000000000000000000000000000000000000000000000000000000000005171 217.0
HKD3_k127_7278241_4 Protein of unknown function (DUF1284) K09706 - - 0.0000000000000000000000000000000005088 134.0
HKD3_k127_7278241_5 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000001726 117.0
HKD3_k127_7294721_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1120.0
HKD3_k127_7294721_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 476.0
HKD3_k127_7294721_2 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000001484 193.0
HKD3_k127_7294721_3 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000001356 134.0
HKD3_k127_7294721_4 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.0000000000000000000001336 100.0
HKD3_k127_7320889_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 423.0
HKD3_k127_7320889_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000001752 237.0
HKD3_k127_7320889_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000006305 181.0
HKD3_k127_7320889_3 MEKHLA domain - - - 0.0000000000000000000000000000000000000000000000005676 179.0
HKD3_k127_7336828_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 355.0
HKD3_k127_7336828_1 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 326.0
HKD3_k127_7336828_2 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 317.0
HKD3_k127_7336828_3 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000002159 151.0
HKD3_k127_7336828_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000002755 155.0
HKD3_k127_7336828_5 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000002038 148.0
HKD3_k127_7336828_6 PFAM Ribosomal protein S27E K02978 - - 0.00000000000000000000134 94.0
HKD3_k127_7336828_7 protein conserved in archaea K09723 - - 0.00000000000000001486 92.0
HKD3_k127_7336828_8 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000008456 72.0
HKD3_k127_7420583_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.521e-213 670.0
HKD3_k127_7420583_1 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 346.0
HKD3_k127_7420583_2 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000000000000000000005547 155.0
HKD3_k127_7420583_3 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.0000000000000000000000000000000000000007616 150.0
HKD3_k127_7420583_4 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000001298 119.0
HKD3_k127_7420583_5 binds to the 23S rRNA K02922 - - 0.000000000000000000000002376 102.0
HKD3_k127_7420583_6 HEPN domain - - - 0.0000000000000000002986 98.0
HKD3_k127_7426105_0 PFAM PilT protein domain protein K06865 - - 3.918e-220 698.0
HKD3_k127_7459270_0 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 425.0
HKD3_k127_7459270_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000003988 258.0
HKD3_k127_7459270_10 PFAM Isochorismatase - - - 0.00005736 46.0
HKD3_k127_7459270_2 KaiC - - - 0.000000000000000000000000000000000000000000000000000001128 203.0
HKD3_k127_7459270_3 Domain of unknown function (DUF1724) - - - 0.000000000000000000000000000000000000000000000000000001767 201.0
HKD3_k127_7459270_4 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000132 148.0
HKD3_k127_7459270_5 - - - - 0.00000000000000000000000003283 123.0
HKD3_k127_7459270_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000193 72.0
HKD3_k127_7459270_7 - - - - 0.00000000001153 70.0
HKD3_k127_7459270_8 - - - - 0.00000000003892 69.0
HKD3_k127_7459270_9 Squalene-hopene cyclase C-terminal domain - - - 0.0000005545 54.0
HKD3_k127_7461407_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.085e-244 765.0
HKD3_k127_7461407_1 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239 - 1.3.5.1,1.3.5.4 2.027e-204 649.0
HKD3_k127_7461407_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 6.973e-199 633.0
HKD3_k127_7461407_3 transposase activity - - - 0.00000000000000000000000000002104 127.0
HKD3_k127_7469190_0 type II secretion system protein K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005815 367.0
HKD3_k127_7469190_1 von Willebrand factor, type A K07114 - - 0.000000000000437 82.0
HKD3_k127_7469190_2 PKD domain containing protein - - - 0.0000000001195 74.0
HKD3_k127_7469190_3 Pfam:DUF1628 - - - 0.0000000002106 68.0
HKD3_k127_7550853_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 489.0
HKD3_k127_7550853_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000003611 239.0
HKD3_k127_7550853_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000001365 222.0
HKD3_k127_7550853_3 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000001529 50.0
HKD3_k127_7553516_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.108e-206 650.0
HKD3_k127_7553516_1 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000004545 178.0
HKD3_k127_7573128_0 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 397.0
HKD3_k127_7573128_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 361.0
HKD3_k127_7573128_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 343.0
HKD3_k127_7573128_3 Phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 311.0
HKD3_k127_7573128_4 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000002402 212.0
HKD3_k127_7573128_5 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000004863 128.0
HKD3_k127_7573128_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.0004793 45.0
HKD3_k127_7577420_0 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 461.0
HKD3_k127_7577420_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 454.0
HKD3_k127_7577420_10 Membrane protein of 12 TMs K01992,K07087 - - 0.00000000000000005503 91.0
HKD3_k127_7577420_11 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000008887 79.0
HKD3_k127_7577420_12 PFAM ABC transporter K01990 - - 0.000000000006101 72.0
HKD3_k127_7577420_2 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 410.0
HKD3_k127_7577420_3 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008743,GO:0009066,GO:0009987,GO:0016043,GO:0016491,GO:0016597,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051287,GO:0051289,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 370.0
HKD3_k127_7577420_4 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 325.0
HKD3_k127_7577420_5 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005036 278.0
HKD3_k127_7577420_6 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000001018 241.0
HKD3_k127_7577420_7 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000002479 229.0
HKD3_k127_7577420_8 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000000619 205.0
HKD3_k127_7577420_9 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000003227 89.0
HKD3_k127_7603736_0 SMART Elongator protein 3 MiaB NifB - - - 1.37e-230 724.0
HKD3_k127_7603736_1 plastoquinone (Complex I) K12137 - - 3.931e-197 634.0
HKD3_k127_7603736_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 468.0
HKD3_k127_7603736_3 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000000000004809 132.0
HKD3_k127_7603736_4 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - - 0.000000000000000000000186 105.0
HKD3_k127_7603736_5 Universal stress protein family - - - 0.0000000000007383 74.0
HKD3_k127_7620976_0 Subtilase family K17734 - - 0.000000000000000000000000000000000000000000000000000000000753 232.0
HKD3_k127_7627360_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 439.0
HKD3_k127_7650663_0 PFAM 4Fe-4S - - - 0.00000000000000000000000000000000000000000000000003125 196.0
HKD3_k127_7650663_1 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000002888 147.0
HKD3_k127_7650663_2 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000004891 85.0
HKD3_k127_7651476_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.714e-200 630.0
HKD3_k127_7651476_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 614.0
HKD3_k127_7651476_2 Protein of unknown function (DUF1646) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 417.0
HKD3_k127_7651476_3 CoB--CoM heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 396.0
HKD3_k127_7651476_4 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 317.0
HKD3_k127_7651476_5 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 301.0
HKD3_k127_7651476_6 PFAM Cytochrome b(N-terminal) b6 petB - - - 0.000000000000000000000000000000000000000008448 166.0
HKD3_k127_7651476_7 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000001071 149.0
HKD3_k127_7651476_8 formate dehydrogenase - - - 0.0000000000000000000000000000000001558 144.0
HKD3_k127_7651476_9 - - - - 0.000000000000000000000000001774 127.0
HKD3_k127_7659404_0 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 299.0
HKD3_k127_7659404_1 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.000000000000000000000000000000000000000000000000000000000000000001572 240.0
HKD3_k127_7659404_2 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000009637 222.0
HKD3_k127_7659404_3 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000003223 216.0
HKD3_k127_7659404_4 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000009328 201.0
HKD3_k127_7659404_5 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000007015 151.0
HKD3_k127_7659404_6 COG0110 Acetyltransferase (isoleucine patch superfamily) - - - 0.0000000000000000000025 100.0
HKD3_k127_7659404_7 Winged helix-turn-helix - - - 0.000000003995 61.0
HKD3_k127_7665230_0 PFAM Prolyl oligopeptidase family - - - 3.542e-282 879.0
HKD3_k127_7665230_1 PFAM Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 286.0
HKD3_k127_7665230_2 membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000001983 194.0
HKD3_k127_7665230_3 Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000003584 175.0
HKD3_k127_7665230_4 - - - - 0.0000000000000000000000001584 109.0
HKD3_k127_7669826_0 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 327.0
HKD3_k127_7669826_1 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000002395 218.0
HKD3_k127_7669826_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000002008 188.0
HKD3_k127_7669826_3 PFAM Queuosine biosynthesis protein K07568 - 2.4.99.17 0.0000000000000000000000000000000006925 134.0
HKD3_k127_7669826_4 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000005005 136.0
HKD3_k127_7669826_5 COG1522 Transcriptional regulators - - - 0.0000000000000000000000001736 114.0
HKD3_k127_7669826_6 - - - - 0.00000000000009512 78.0
HKD3_k127_7669826_7 - - - - 0.00000000003892 69.0
HKD3_k127_7673071_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 532.0
HKD3_k127_7673071_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 335.0
HKD3_k127_7758035_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 6.216e-217 680.0
HKD3_k127_7758035_1 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 326.0
HKD3_k127_7758035_2 PemK-like, MazF-like toxin of type II toxin-antitoxin system - - - 0.00000000000000000000000000000000003383 137.0
HKD3_k127_7758035_3 - - - - 0.00000000000002013 76.0
HKD3_k127_7769304_0 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 422.0
HKD3_k127_7769304_1 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006957 266.0
HKD3_k127_7769304_10 - - - - 0.00000000006204 63.0
HKD3_k127_7769304_11 - - - - 0.0004646 47.0
HKD3_k127_7769304_12 Possibly the antitoxin component of a type II toxin- antitoxin (TA) system - - - 0.0007807 45.0
HKD3_k127_7769304_2 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000005866 239.0
HKD3_k127_7769304_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000002288 231.0
HKD3_k127_7769304_4 Rhomboid family K07059 - - 0.00000000000000000000000000000000000000000000000000000000000000024 229.0
HKD3_k127_7769304_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000001959 192.0
HKD3_k127_7769304_6 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000624 175.0
HKD3_k127_7769304_7 transcriptional - - - 0.0000000000000000000000000000009147 124.0
HKD3_k127_7769304_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000867 113.0
HKD3_k127_7769304_9 - - - - 0.000000000000005452 82.0
HKD3_k127_7792219_0 Uncharacterized protein family (UPF0051) K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009464 481.0
HKD3_k127_7792219_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 361.0
HKD3_k127_7792219_2 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 321.0
HKD3_k127_7792219_3 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001217 252.0
HKD3_k127_7792219_4 - - - - 0.000000000000000000000000000000000000000000000000000009219 202.0
HKD3_k127_7792219_5 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.000000000000000000000000001119 113.0
HKD3_k127_7792219_6 structural constituent of ribosome K02924 - - 0.000000000000001089 78.0
HKD3_k127_7792219_7 metal-sulfur cluster biosynthetic - - - 0.000001204 51.0
HKD3_k127_7792219_8 - - - - 0.000001831 55.0
HKD3_k127_7807565_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1445.0
HKD3_k127_7807565_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 7.797e-217 679.0
HKD3_k127_7807565_2 - - - - 0.0000003037 53.0
HKD3_k127_7853862_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 464.0
HKD3_k127_7853862_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 372.0
HKD3_k127_7853862_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 367.0
HKD3_k127_7853862_3 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000003956 189.0
HKD3_k127_7853862_4 Domain of unknown function DUF123 - - - 0.0000000000000000000000000000000007669 135.0
HKD3_k127_7853862_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000001056 106.0
HKD3_k127_7853862_6 - - - - 0.000009288 53.0
HKD3_k127_7856432_0 membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003123 290.0
HKD3_k127_7856432_1 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000003849 207.0
HKD3_k127_7856432_2 - - - - 0.000000000000000001549 88.0
HKD3_k127_7937343_0 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 492.0
HKD3_k127_7937343_1 PFAM Aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 417.0
HKD3_k127_7937343_2 4Fe-4S binding domain - - - 0.00000000000000000118 87.0
HKD3_k127_7946522_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000001821 89.0
HKD3_k127_7946522_1 transposase IS200-family protein K07491 - - 0.000000003503 60.0
HKD3_k127_7946522_2 COG3335 Transposase and inactivated derivatives - - - 0.00001608 50.0
HKD3_k127_7965154_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 389.0
HKD3_k127_7965154_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 371.0
HKD3_k127_7965154_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 358.0
HKD3_k127_7965154_3 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009461 312.0
HKD3_k127_7965154_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001242 274.0
HKD3_k127_7965154_5 binds to the 23S rRNA K02921 - - 0.00000000000000000001793 92.0
HKD3_k127_7965154_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000002847 94.0
HKD3_k127_7965154_7 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000000004931 67.0
HKD3_k127_7973212_0 Heterodisulfide reductase subunit A and related polyferredoxins K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.36e-287 909.0
HKD3_k127_7973212_1 heterodisulfide reductase K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 295.0
HKD3_k127_7973212_2 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000001931 233.0
HKD3_k127_7973212_3 4Fe-4S dicluster domain K03390,K16887 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000001135 137.0
HKD3_k127_7978410_0 Heterodisulfide reductase subunit A and related polyferredoxins K03388,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 529.0
HKD3_k127_7978410_1 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000155 246.0
HKD3_k127_7978410_2 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000002416 135.0
HKD3_k127_7978410_3 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000004547 138.0
HKD3_k127_798761_0 N-6 DNA Methylase K03427 - 2.1.1.72 1.075e-255 796.0
HKD3_k127_798761_1 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 459.0
HKD3_k127_798761_2 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000007908 213.0
HKD3_k127_798761_3 Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.000001979 49.0
HKD3_k127_798761_4 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297,K00547 - 1.5.1.20,2.1.1.10 0.000007923 49.0
HKD3_k127_8002700_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 607.0
HKD3_k127_8002700_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 610.0
HKD3_k127_8002700_2 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 556.0
HKD3_k127_8002700_3 KaiB K08481 - - 0.0000000000000000000000000000000000007821 141.0
HKD3_k127_8002700_4 Nucleoside 2-deoxyribosyltransferase like K08728 - 2.4.2.6 0.00000000000000000000000000000000004367 138.0
HKD3_k127_8002700_5 - - - - 0.00000000000000008566 81.0
HKD3_k127_8026879_0 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006693 402.0
HKD3_k127_8026879_1 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000006908 233.0
HKD3_k127_8026879_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000005051 93.0
HKD3_k127_8026879_3 metal-dependent protease of the PAD1 JAB1 superfamily K21140 - 3.13.1.6 0.000000000002236 72.0
HKD3_k127_8026879_4 Possibly the antitoxin component of a - - - 0.0007322 46.0
HKD3_k127_8029910_0 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 378.0
HKD3_k127_8029910_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 340.0
HKD3_k127_8029910_2 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000008455 236.0
HKD3_k127_8029910_3 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000003006 230.0
HKD3_k127_8029910_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.000000000000000000000000001016 113.0
HKD3_k127_8030098_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005058 385.0
HKD3_k127_8030098_1 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000000003377 210.0
HKD3_k127_8030098_2 - - - - 0.00000000000000000000002069 110.0
HKD3_k127_8030098_3 Protein of unknown function (DUF356) K09727 - - 0.000001122 57.0
HKD3_k127_8058525_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 8.704e-272 844.0
HKD3_k127_8058525_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000004705 234.0
HKD3_k127_8058525_2 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000003051 145.0
HKD3_k127_8058525_3 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.0000000000002116 70.0
HKD3_k127_8063310_0 helicase superfamily c-terminal domain - - - 7.033e-230 717.0
HKD3_k127_8063310_1 Protein of unknown function (DUF790) K09744 - - 1.121e-224 705.0
HKD3_k127_8063310_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001052 284.0
HKD3_k127_8063310_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003002 256.0
HKD3_k127_8063310_4 - - - - 0.000000000000002503 78.0
HKD3_k127_8063906_0 Belongs to the aconitase IPM isomerase family K01682 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:0097159,GO:1901363,GO:1901575 4.2.1.3,4.2.1.99 0.0 1032.0
HKD3_k127_8063906_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000000000000000000007887 246.0
HKD3_k127_8063906_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000004356 104.0
HKD3_k127_8063906_3 - - - - 0.00000000000000005487 90.0
HKD3_k127_8063906_4 Ribbon-helix-helix protein, copG family - - - 0.0006339 46.0
HKD3_k127_8080949_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 536.0
HKD3_k127_8080949_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 478.0
HKD3_k127_8080949_10 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000173 66.0
HKD3_k127_8080949_2 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 347.0
HKD3_k127_8080949_3 PFAM metallophosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004437 339.0
HKD3_k127_8080949_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 316.0
HKD3_k127_8080949_5 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000307 244.0
HKD3_k127_8080949_6 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000001254 199.0
HKD3_k127_8080949_7 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000000000000000006057 147.0
HKD3_k127_8080949_8 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000001818 140.0
HKD3_k127_8080949_9 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000002048 71.0
HKD3_k127_8092275_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 7.376e-314 969.0
HKD3_k127_8092275_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 7.153e-243 761.0
HKD3_k127_8092275_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000017 271.0
HKD3_k127_8092275_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002051 272.0
HKD3_k127_8092275_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000008223 86.0
HKD3_k127_8107458_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 420.0
HKD3_k127_8107458_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 379.0
HKD3_k127_8107458_10 V4R K07013 - - 0.00000000000006336 78.0
HKD3_k127_8107458_11 - - - - 0.0000000000009902 70.0
HKD3_k127_8107458_12 - - - - 0.00000000005184 71.0
HKD3_k127_8107458_13 VIT family - - - 0.00000000009722 66.0
HKD3_k127_8107458_14 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000226 53.0
HKD3_k127_8107458_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 344.0
HKD3_k127_8107458_3 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 288.0
HKD3_k127_8107458_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000003361 191.0
HKD3_k127_8107458_5 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000000000000000000000001391 162.0
HKD3_k127_8107458_6 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000007689 154.0
HKD3_k127_8107458_7 - - - - 0.0000000000000000000000000000000000000001015 164.0
HKD3_k127_8107458_8 - - - - 0.0000000000000000000000006394 106.0
HKD3_k127_8107458_9 - - - - 0.000000000000000002973 98.0
HKD3_k127_8140521_0 Protein of unknown function (DUF790) K09744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 610.0
HKD3_k127_8140521_1 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000003385 199.0
HKD3_k127_8140521_2 SNARE associated Golgi protein K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0000000000000000000000000000000000000000000001462 171.0
HKD3_k127_815314_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 3.93e-203 645.0
HKD3_k127_815314_1 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.000000000000000000000000000000000000000000000002968 177.0
HKD3_k127_8159607_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 534.0
HKD3_k127_8159607_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000002202 243.0
HKD3_k127_8159607_2 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000347 197.0
HKD3_k127_8159607_3 Protein of unknown function (DUF98) - - - 0.0000000000000000000000000000000000000000000000001023 183.0
HKD3_k127_8159607_4 - - - - 0.0000000000000000000000000011 115.0
HKD3_k127_8159607_5 - - - - 0.00000000000000008687 88.0
HKD3_k127_8159607_6 Glutaredoxin - - - 0.00000003771 58.0
HKD3_k127_8197639_0 Probable transposase K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001305 260.0
HKD3_k127_8197639_1 Phage integrase family - - - 0.00000000000000000000000000000000000000004232 158.0
HKD3_k127_8197639_2 Phage integrase family - - - 0.000000000000000000000000000000000000001007 151.0
HKD3_k127_8197639_3 Probable transposase K07496 - - 0.0000000000000000387 84.0
HKD3_k127_8197639_4 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000001391 81.0
HKD3_k127_8197639_5 Transposase - - - 0.00000002394 56.0
HKD3_k127_8217647_0 PFAM type II secretion system protein E K07332 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 519.0
HKD3_k127_8217647_1 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009815 293.0
HKD3_k127_8217647_2 KH domain protein K06961 - - 0.0000000000000000000000000000000000000000000000000000000000006232 214.0
HKD3_k127_8217647_3 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000002643 154.0
HKD3_k127_8217647_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 - 2.3.1.234 0.000000000000007841 75.0
HKD3_k127_8266863_0 Phage protein D K06905 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 346.0
HKD3_k127_8266863_1 Rhs element vgr protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003608 249.0
HKD3_k127_8266863_2 PAAR motif - - - 0.000000000000000000000000000000000000000000000000000000000001248 211.0
HKD3_k127_8266863_3 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000054 199.0
HKD3_k127_8266863_4 Gene 25-like lysozyme K06903 - - 0.00000000000000000000000000000000001552 137.0
HKD3_k127_82872_0 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001314 259.0
HKD3_k127_82872_1 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000008775 213.0
HKD3_k127_82872_2 Flavodoxin - - - 0.000000000000000000000000000000000000000000000000000000001522 206.0
HKD3_k127_82872_3 - - - - 0.000000000000000004703 92.0
HKD3_k127_8419168_0 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 555.0
HKD3_k127_8419168_1 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 263.0
HKD3_k127_8427145_0 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 292.0
HKD3_k127_8427145_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000003653 242.0
HKD3_k127_8427145_2 ABC-type tungstate transport system, periplasmic component K05773 - - 0.000000000000000000000000000000000000000000000000000002023 199.0
HKD3_k127_8427145_3 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000001649 190.0
HKD3_k127_8427145_4 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000000000000000000000000000000001111 160.0
HKD3_k127_8427145_5 HTH transcriptional regulator, MerR - - - 0.00000000000000000000000000000000000000000223 163.0
HKD3_k127_8427145_6 Transposase - - - 0.00000000000000000000000001253 123.0
HKD3_k127_8427145_7 HEPN domain - - - 0.00000000003669 65.0
HKD3_k127_8451650_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000625 265.0
HKD3_k127_8451650_1 pfam ammecr1 K09141 - - 0.000000000000000000000000000000000000000000000000000000000000003406 222.0
HKD3_k127_8451650_2 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000000000004157 134.0
HKD3_k127_8451650_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000003745 81.0
HKD3_k127_846146_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 394.0
HKD3_k127_846146_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000002655 229.0
HKD3_k127_846146_2 Transcriptional regulator, AbrB family K06193 - - 0.0000000000000000000000000000002421 124.0
HKD3_k127_846146_3 - - - - 0.0000000000000000009324 87.0
HKD3_k127_846146_4 low-complexity proteins - - - 0.000000002488 62.0
HKD3_k127_846146_5 - - - - 0.00002238 53.0
HKD3_k127_8473267_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 2.77e-263 824.0
HKD3_k127_8473267_1 PFAM Radical SAM domain protein K06937 - - 7.775e-196 622.0
HKD3_k127_8473267_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 566.0
HKD3_k127_8473267_3 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 459.0
HKD3_k127_8473267_4 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002852 267.0
HKD3_k127_8473267_5 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000000000000000000000008639 158.0
HKD3_k127_8473267_6 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000001483 153.0
HKD3_k127_8473267_7 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000007307 145.0
HKD3_k127_8473267_8 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000111 110.0
HKD3_k127_8474132_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 9.018e-228 712.0
HKD3_k127_8474132_1 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 2.662e-201 646.0
HKD3_k127_8474132_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.04e-199 629.0
HKD3_k127_8474132_3 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 467.0
HKD3_k127_8474132_4 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000000002215 93.0
HKD3_k127_8478389_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 3.578e-300 928.0
HKD3_k127_8478389_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 436.0
HKD3_k127_8478389_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 400.0
HKD3_k127_8478389_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 348.0
HKD3_k127_8478389_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000000000000000005928 163.0
HKD3_k127_8478389_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000001938 125.0
HKD3_k127_8478389_6 ATP synthase subunit C K02124 - - 0.00000000000000000000183 97.0
HKD3_k127_8489418_0 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 350.0
HKD3_k127_8489418_1 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000341 261.0
HKD3_k127_8489418_2 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000001193 194.0
HKD3_k127_8489418_3 PIN domain - - - 0.000000000000006383 79.0
HKD3_k127_8489418_4 AbrB family - - - 0.000000001394 62.0
HKD3_k127_8489418_5 - - - - 0.000001373 57.0
HKD3_k127_8521484_0 UPF0210 protein K09157 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 582.0
HKD3_k127_8521484_1 PFAM elongation factor Tu domain 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 352.0
HKD3_k127_8521484_2 Belongs to the UPF0237 family K07166 - - 0.000000000000000006907 86.0
HKD3_k127_8521484_3 - - - - 0.00000000000000009947 81.0
HKD3_k127_8521484_4 TIGRFAM transposase, IS605 OrfB family, central region K07496 - - 0.0006705 49.0
HKD3_k127_8567295_0 ThiF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 344.0
HKD3_k127_8567295_1 FMN binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 295.0
HKD3_k127_8567295_10 DsrE/DsrF-like family K07236 - - 0.0000000004035 64.0
HKD3_k127_8567295_11 PFAM DsrE K07235 - - 0.000000003988 61.0
HKD3_k127_8567295_12 Transposase IS116/IS110/IS902 family - - - 0.000008044 52.0
HKD3_k127_8567295_13 Family of unknown function (DUF5371) - - - 0.00001817 50.0
HKD3_k127_8567295_14 sulfur relay protein K07237 GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - 0.0001663 48.0
HKD3_k127_8567295_15 Transposase - - - 0.0002035 46.0
HKD3_k127_8567295_16 - - - - 0.0005876 47.0
HKD3_k127_8567295_2 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001102 265.0
HKD3_k127_8567295_3 Resolvase K06400 - - 0.0000000000000000000000000000000000000000000000000004171 188.0
HKD3_k127_8567295_4 recombinase activity K06400 - - 0.0000000000000000000000000000000000000000000000001404 192.0
HKD3_k127_8567295_5 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000000000000008542 175.0
HKD3_k127_8567295_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000005596 135.0
HKD3_k127_8567295_7 Sulfurtransferase TusA K04085 - - 0.0000000000000000000006961 96.0
HKD3_k127_8567295_8 Transcriptional regulator - - - 0.00000000000006306 76.0
HKD3_k127_8579448_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 5.606e-286 889.0
HKD3_k127_8579448_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 2.275e-229 723.0
HKD3_k127_8579448_2 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000002713 204.0
HKD3_k127_8579448_3 PFAM ATPase, BadF BadG BcrA BcrD type K09680 - 2.7.1.33 0.0000000000000000000000000000000000000000002892 165.0
HKD3_k127_859237_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 441.0
HKD3_k127_859237_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 331.0
HKD3_k127_859237_2 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000001215 234.0
HKD3_k127_859237_3 Subtilase family K17734 - - 0.000000000000000000000000000000000000007569 167.0
HKD3_k127_859237_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00001269 58.0
HKD3_k127_8642285_0 S-layer protein - - - 0.000000000000000000000000000001877 135.0
HKD3_k127_8642285_1 Patched family K07003 - - 0.000000000000000000000003627 111.0
HKD3_k127_8682051_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 377.0
HKD3_k127_8682051_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 289.0
HKD3_k127_8682051_2 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000002526 231.0
HKD3_k127_8682051_3 denitrification pathway K02569,K15876 - - 0.000000000000000000000000000000000000000000000000000875 197.0
HKD3_k127_8682051_4 - - - - 0.000000000000000000000000000001035 126.0
HKD3_k127_8682051_5 Cupin domain - - - 0.000000000000000000000000000001307 124.0
HKD3_k127_8682051_6 formate dehydrogenase - - - 0.000000004952 67.0
HKD3_k127_8682051_7 TIGRFAM looped-hinge helix DNA binding domain, AbrB family - - - 0.0007031 47.0
HKD3_k127_8745628_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 514.0
HKD3_k127_8745628_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006539 507.0
HKD3_k127_8745628_10 Psort location Cytoplasmic, score - - - 0.00000002359 65.0
HKD3_k127_8745628_2 histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 306.0
HKD3_k127_8745628_3 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term K22162 - 1.5.7.2,1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 298.0
HKD3_k127_8745628_4 YoaP-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001674 270.0
HKD3_k127_8745628_5 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000007878 243.0
HKD3_k127_8745628_6 transcription activator, effector binding - - - 0.000000000000000000000000000000000000000000000000000000000001827 220.0
HKD3_k127_8745628_7 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000001606 212.0
HKD3_k127_8745628_8 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000001253 154.0
HKD3_k127_8745628_9 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000001102 102.0
HKD3_k127_8757559_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 456.0
HKD3_k127_8757559_1 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002423 258.0
HKD3_k127_8757559_2 Transposase DDE domain - - - 0.000000000000000000000007388 108.0
HKD3_k127_8757559_3 ThiS family K03636 - - 0.0000000000000000000004112 98.0
HKD3_k127_8767423_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 1.076e-206 659.0
HKD3_k127_8767423_1 S-layer protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 579.0
HKD3_k127_8767423_2 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 286.0
HKD3_k127_8767423_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000004231 210.0
HKD3_k127_8767423_4 PAS domain - - - 0.00000000000000000000000000000000000001038 167.0
HKD3_k127_8767423_5 KaiB K08481 - - 0.000000000000000000000000000000000007645 139.0
HKD3_k127_8767423_6 Histidine kinase - - - 0.00000000000000000000000000000006438 145.0
HKD3_k127_8767423_7 Putative zinc- or iron-chelating domain K06940 - - 0.00008729 50.0
HKD3_k127_8767423_8 Winged helix-turn-helix - - - 0.0003116 44.0
HKD3_k127_8767423_9 KaiB domain protein K08481 - - 0.0006291 42.0
HKD3_k127_8808785_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 8.389e-220 688.0
HKD3_k127_8808785_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 459.0
HKD3_k127_8808785_2 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000009419 255.0
HKD3_k127_8808785_3 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000006662 248.0
HKD3_k127_8830111_0 Heat shock 70 kDa protein K04043 - - 4.736e-278 866.0
HKD3_k127_8830111_1 ATPase, P-type transporting, HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 346.0
HKD3_k127_8830111_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000003752 49.0
HKD3_k127_8834138_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 429.0
HKD3_k127_8834138_1 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 338.0
HKD3_k127_8834138_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 299.0
HKD3_k127_8834138_3 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000003259 245.0
HKD3_k127_8834138_4 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000000000008182 191.0
HKD3_k127_8834138_5 PFAM transposase IS200-family protein K07491 - - 0.0000000000000002826 81.0
HKD3_k127_8918118_0 PFAM amine oxidase - - - 1.162e-197 623.0
HKD3_k127_8918118_1 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 417.0
HKD3_k127_8918118_2 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000005951 216.0
HKD3_k127_8964279_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 305.0
HKD3_k127_8964279_1 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005533 263.0
HKD3_k127_8964279_10 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.000000000000000000000000000000000000006646 147.0
HKD3_k127_8964279_11 PFAM Ribosomal protein K02912 - - 0.000000000000000000000000000000000504 136.0
HKD3_k127_8964279_12 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.000000000000000000000688 94.0
HKD3_k127_8964279_13 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000001289 94.0
HKD3_k127_8964279_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000003867 224.0
HKD3_k127_8964279_3 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000009104 222.0
HKD3_k127_8964279_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000007916 219.0
HKD3_k127_8964279_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000001768 196.0
HKD3_k127_8964279_6 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000003213 188.0
HKD3_k127_8964279_7 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000006612 187.0
HKD3_k127_8964279_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000002294 176.0
HKD3_k127_8964279_9 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000398 171.0
HKD3_k127_8977310_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.175e-300 949.0
HKD3_k127_8986666_0 small GTP-binding protein K06945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 432.0
HKD3_k127_8986666_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 360.0
HKD3_k127_8986666_2 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 284.0
HKD3_k127_8986666_3 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001787 256.0
HKD3_k127_8986666_4 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000000003778 211.0
HKD3_k127_8986666_5 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000003585 203.0
HKD3_k127_8986666_6 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000001004 143.0
HKD3_k127_8986666_7 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000003097 125.0
HKD3_k127_8986666_8 Roadblock LC7 family protein K07131 - - 0.0000000000000000000000000000006947 125.0
HKD3_k127_8986666_9 RNA-binding protein containing KH domain, possibly ribosomal protein K07574 - - 0.0000000000005766 71.0
HKD3_k127_8994542_0 FAD linked oxidases, C-terminal domain - - - 0.0 1563.0
HKD3_k127_9014722_0 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000001924 254.0
HKD3_k127_9014722_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088,K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000002512 224.0
HKD3_k127_9014722_2 DNA polymerase Ligase (LigD) - - - 0.00000000000004175 73.0
HKD3_k127_9014722_3 - - - - 0.0001185 49.0
HKD3_k127_9020365_0 Flavodoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 421.0
HKD3_k127_9020365_1 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000008129 224.0
HKD3_k127_9020365_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000003885 216.0
HKD3_k127_9020365_3 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000004889 195.0
HKD3_k127_9020365_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000000000000000000001616 190.0
HKD3_k127_9020365_5 - - - - 0.0000000000000000000000000000008181 125.0
HKD3_k127_9020365_6 Domain of unknown function (DU1801) - - - 0.000000000000000000000000001651 112.0
HKD3_k127_9020365_7 Flavodoxin - - - 0.00000000000000000000000001963 110.0
HKD3_k127_9020365_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000001779 107.0
HKD3_k127_9020365_9 glyoxalase III activity - - - 0.000000000000000000000001002 107.0
HKD3_k127_9030586_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 413.0
HKD3_k127_9062918_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.0 1067.0
HKD3_k127_9062918_1 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 551.0
HKD3_k127_9062918_10 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000508 163.0
HKD3_k127_9062918_11 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000000000000000000000000001251 136.0
HKD3_k127_9062918_12 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000003804 105.0
HKD3_k127_9062918_13 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000003054 79.0
HKD3_k127_9062918_14 Protein of unknown function DUF131 - - - 0.000000000001299 70.0
HKD3_k127_9062918_15 Protein of unknown function DUF131 - - - 0.0000000000318 67.0
HKD3_k127_9062918_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 467.0
HKD3_k127_9062918_3 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 289.0
HKD3_k127_9062918_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001632 256.0
HKD3_k127_9062918_5 'COG1121 ABC-type Mn Zn transport systems, ATPase component' K02074,K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001882 258.0
HKD3_k127_9062918_6 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001927 247.0
HKD3_k127_9062918_7 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000000000000000000000000000002783 212.0
HKD3_k127_9062918_8 PFAM regulatory protein AsnC Lrp family - - - 0.0000000000000000000000000000000000000000000000000000000002002 207.0
HKD3_k127_9062918_9 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.0000000000000000000000000000000000000000000004271 173.0
HKD3_k127_9096363_0 sulfate adenylyltransferase K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 488.0
HKD3_k127_9096363_1 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001752 243.0
HKD3_k127_9096363_2 - - - - 0.0000000000000000000000000008142 118.0
HKD3_k127_9096363_3 Uncharacterised protein family (UPF0175) - - - 0.0004631 45.0
HKD3_k127_9229554_0 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 599.0
HKD3_k127_9229554_1 Late control gene D protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003525 257.0
HKD3_k127_9229554_2 Rhs element vgr protein - - - 0.0000000000000000000000000000000000000000000004823 172.0
HKD3_k127_9229554_3 homolog of phage Mu protein gp47 - - - 0.0000000000000000000000000000000000002878 149.0
HKD3_k127_9229554_4 - - - - 0.0000000000000000000000000000000009151 138.0
HKD3_k127_9229554_5 Gene 25-like lysozyme K06903 - - 0.0000000000000000000000000005815 116.0
HKD3_k127_9229554_6 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000003686 126.0
HKD3_k127_9229554_7 - - - - 0.0000000000000000000008082 98.0
HKD3_k127_9229554_8 LysM domain - - - 0.0000000000000000142 85.0
HKD3_k127_9282594_0 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 341.0
HKD3_k127_9282594_1 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003979 269.0
HKD3_k127_9282594_2 Ferritin-like domain - - - 0.000001617 57.0
HKD3_k127_9322355_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000001146 251.0
HKD3_k127_9322355_1 serine-type aminopeptidase activity K14475 - - 0.0000000000000000000000000000000000001581 146.0
HKD3_k127_9322355_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000003218 145.0
HKD3_k127_9322355_3 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000001862 54.0
HKD3_k127_9322355_4 - - - - 0.000006525 57.0
HKD3_k127_9322355_5 Lanthionine synthetase C-like protein - - - 0.0002464 51.0
HKD3_k127_94606_0 COG1668 ABC-type Na efflux pump, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003536 254.0
HKD3_k127_94606_1 Ferredoxin - - - 0.00000000000000000000000000000000000000000002091 164.0
HKD3_k127_94606_2 Multicopper - - - 0.00000000000000000000008732 101.0
HKD3_k127_94606_3 Multicopper - - - 0.0000000000002129 70.0
HKD3_k127_9474485_0 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0001603 46.0
HKD3_k127_9474754_0 Iron-sulfur cluster-binding domain K06871 - - 2.715e-195 614.0
HKD3_k127_9474754_1 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 471.0
HKD3_k127_9474754_2 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003592 276.0
HKD3_k127_9474754_3 RuvA, C-terminal domain K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000001039 198.0
HKD3_k127_9474754_4 - - - - 0.0000000000000000000000000000000004601 138.0
HKD3_k127_9474754_5 Protein conserved in bacteria - - - 0.000005344 55.0
HKD3_k127_9481960_0 - - - - 0.000000000000000000007711 100.0
HKD3_k127_9481960_1 - - - - 0.00000000002586 66.0
HKD3_k127_9481960_2 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0001349 53.0
HKD3_k127_9505622_0 S-layer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 611.0
HKD3_k127_9505622_1 Radical SAM ThiC family K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007967 354.0
HKD3_k127_9505622_2 ATPase domain predominantly from Archaea K06921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 359.0
HKD3_k127_9505622_3 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 338.0
HKD3_k127_9505622_4 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005081 316.0
HKD3_k127_9505622_5 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 297.0
HKD3_k127_9540936_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 1.418e-223 700.0
HKD3_k127_9540936_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 2.642e-212 666.0
HKD3_k127_9540936_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001265 289.0
HKD3_k127_9540936_3 PFAM Aspartate glutamate uridylate kinase K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000004011 167.0
HKD3_k127_9540936_4 Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base - GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 - 0.00000000000000000000000000000000000002757 148.0
HKD3_k127_9540936_5 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000002331 81.0
HKD3_k127_9574092_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 348.0
HKD3_k127_9574092_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001295 277.0
HKD3_k127_9574092_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000000000000001313 126.0
HKD3_k127_9574092_3 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000003869 78.0
HKD3_k127_9617681_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 590.0
HKD3_k127_9617681_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000123 280.0
HKD3_k127_9617681_2 PFAM conserved - - - 0.00000000000000000000000000000000000000003215 159.0
HKD3_k127_9617681_3 Domain of unknown function (DUF1894) - - - 0.0000000000002376 73.0
HKD3_k127_9629467_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009201 262.0
HKD3_k127_9629467_1 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000000000001637 115.0
HKD3_k127_9629707_0 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 320.0
HKD3_k127_9629707_1 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000004551 175.0
HKD3_k127_9629707_2 Ethylbenzene dehydrogenase - - - 0.0001859 46.0
HKD3_k127_9649001_0 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 441.0
HKD3_k127_9649001_1 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002215 266.0
HKD3_k127_9649001_2 membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000004121 222.0
HKD3_k127_9649001_3 PFAM LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000269 207.0
HKD3_k127_9649001_4 - - - - 0.00000000000000000000000000000000000000000000000000000004458 200.0
HKD3_k127_9649001_5 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000001328 173.0
HKD3_k127_9649001_6 - - - - 0.00000000000000000001656 96.0
HKD3_k127_9649001_7 4Fe-4S dicluster domain - - - 0.0000000003326 62.0
HKD3_k127_97895_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 574.0
HKD3_k127_97895_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 459.0
HKD3_k127_97895_10 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.0000000000000000000000000000000002115 136.0
HKD3_k127_97895_11 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases K03641 - - 0.000000000000000000001832 107.0
HKD3_k127_97895_12 Predicted RNA-binding protein - - - 0.000004433 51.0
HKD3_k127_97895_2 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 325.0
HKD3_k127_97895_3 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 297.0
HKD3_k127_97895_4 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004104 261.0
HKD3_k127_97895_5 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002011 256.0
HKD3_k127_97895_6 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000002738 235.0
HKD3_k127_97895_7 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000000000000000000000000000000009139 226.0
HKD3_k127_97895_8 Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000009656 184.0
HKD3_k127_97895_9 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000003526 148.0