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Overview

ID MAG01879
Name HKD3_bin.81
Sample SMP0048
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JAJRCY01
Species
Assembly information
Completeness (%) 60.75
Contamination (%) 1.66
GC content (%) 64.0
N50 (bp) 3,943
Genome size (bp) 1,134,672

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1318

Gene name Description KEGG GOs EC E-value Score Sequence
HKD3_k127_1024641_0 PFAM SufBD protein K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 518.0
HKD3_k127_1024641_1 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 288.0
HKD3_k127_1024641_2 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000065 274.0
HKD3_k127_1069549_0 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 375.0
HKD3_k127_1069549_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000008416 248.0
HKD3_k127_1069549_2 PFAM amino acid-binding ACT domain protein K06862 - - 0.0000000000000128 73.0
HKD3_k127_1120611_0 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 331.0
HKD3_k127_1120611_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001962 253.0
HKD3_k127_1120611_2 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000008954 224.0
HKD3_k127_1120611_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000002179 76.0
HKD3_k127_1203655_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 546.0
HKD3_k127_1203655_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000001286 239.0
HKD3_k127_1212071_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.366e-220 691.0
HKD3_k127_1212071_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 426.0
HKD3_k127_1212071_2 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 319.0
HKD3_k127_1212071_3 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000007991 226.0
HKD3_k127_1212071_4 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000006447 105.0
HKD3_k127_1226541_0 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 437.0
HKD3_k127_1226541_1 COG1226 Kef-type K transport systems K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001369 289.0
HKD3_k127_1226541_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000002932 239.0
HKD3_k127_1226541_3 TIR domain - - - 0.00000000000000000000000000000000000000000000000008868 194.0
HKD3_k127_1226541_4 Alternative locus ID - - - 0.0000000000000000000000000000001929 139.0
HKD3_k127_1236708_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003079 265.0
HKD3_k127_1236708_1 Domain of unknown function (DUF4962) - - - 0.0000000000000000000000000006911 132.0
HKD3_k127_1236708_2 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.000000000000000007439 97.0
HKD3_k127_1236708_3 YD repeat - - - 0.0009806 51.0
HKD3_k127_12429_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 468.0
HKD3_k127_12429_1 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 356.0
HKD3_k127_12429_2 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000366 274.0
HKD3_k127_12429_3 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000431 273.0
HKD3_k127_12429_4 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004624 246.0
HKD3_k127_12429_5 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001436 237.0
HKD3_k127_12429_6 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000001621 87.0
HKD3_k127_1244972_0 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000594 265.0
HKD3_k127_1244972_1 protein conserved in archaea - - - 0.0000000000000000000000000000000000000000001836 168.0
HKD3_k127_1244972_2 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000004233 123.0
HKD3_k127_1256897_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.216e-219 697.0
HKD3_k127_1256897_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 524.0
HKD3_k127_1256897_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 429.0
HKD3_k127_1256897_3 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 362.0
HKD3_k127_1256897_4 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 317.0
HKD3_k127_1256897_5 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000004988 216.0
HKD3_k127_1256897_6 - - - - 0.000000000000000000000000000000000000000000005717 168.0
HKD3_k127_1256897_7 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 0.000000000000000000000000000000000000005493 161.0
HKD3_k127_1256897_8 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000000009512 152.0
HKD3_k127_1278485_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 476.0
HKD3_k127_1278485_1 Belongs to the peptidase S8 family K13277 GO:0005575,GO:0005576 - 0.000000000000000000000000000000000000000000000000000000000000000000002124 253.0
HKD3_k127_1278485_2 - - - - 0.00000000000000006616 87.0
HKD3_k127_1311564_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000887 324.0
HKD3_k127_1311564_1 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000002348 235.0
HKD3_k127_1311564_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000001522 133.0
HKD3_k127_1311564_3 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000000001055 116.0
HKD3_k127_1311564_4 methanogen marker protein 4 - - - 0.000000000000000000000000003709 111.0
HKD3_k127_1318532_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 462.0
HKD3_k127_1318532_1 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 394.0
HKD3_k127_1318532_2 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000004775 87.0
HKD3_k127_1318532_3 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000005707 57.0
HKD3_k127_133992_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 566.0
HKD3_k127_133992_1 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002188 241.0
HKD3_k127_133992_2 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000000009436 178.0
HKD3_k127_133992_3 Belongs to the UPF0288 family - - - 0.00000000000000002588 81.0
HKD3_k127_1376749_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 550.0
HKD3_k127_1376749_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 547.0
HKD3_k127_1376749_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006924 287.0
HKD3_k127_1376749_3 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000001375 109.0
HKD3_k127_1378591_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 519.0
HKD3_k127_1378591_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 440.0
HKD3_k127_1378591_2 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000000000000000000000009251 188.0
HKD3_k127_1378591_3 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.0000000000000000000000000000000000000000000005932 169.0
HKD3_k127_1378591_4 PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A K01895,K01908 - 6.2.1.1,6.2.1.17 0.0000000000000000000000003444 105.0
HKD3_k127_1378591_5 PFAM Protein kinase domain - - - 0.000000000000003438 84.0
HKD3_k127_138069_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.436e-233 734.0
HKD3_k127_138069_1 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007049 339.0
HKD3_k127_138069_2 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 302.0
HKD3_k127_138069_3 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008109 261.0
HKD3_k127_138069_4 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000000000000001178 223.0
HKD3_k127_138069_5 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000005124 222.0
HKD3_k127_138069_6 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000001141 144.0
HKD3_k127_138069_7 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000003495 87.0
HKD3_k127_138069_8 - - - - 0.000000000002079 72.0
HKD3_k127_138069_9 - - - - 0.0001844 51.0
HKD3_k127_1404691_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1149.0
HKD3_k127_1404691_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.363e-213 672.0
HKD3_k127_1404691_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004065 266.0
HKD3_k127_1404691_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0003445 50.0
HKD3_k127_1461928_0 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 344.0
HKD3_k127_1461928_1 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000000000003705 210.0
HKD3_k127_1461928_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000006396 203.0
HKD3_k127_1461928_3 - - - - 0.0000000000000000007368 92.0
HKD3_k127_1463620_0 protein conserved in archaea - - - 0.0000000000000000000000000000000000000000004296 165.0
HKD3_k127_1463620_1 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000001379 98.0
HKD3_k127_1463620_2 - - - - 0.000002231 52.0
HKD3_k127_1540772_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 5.552e-197 617.0
HKD3_k127_1540772_1 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 435.0
HKD3_k127_1540772_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 379.0
HKD3_k127_1540772_3 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003146 255.0
HKD3_k127_1540772_4 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000001748 79.0
HKD3_k127_1593072_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 366.0
HKD3_k127_1593072_1 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 302.0
HKD3_k127_1593072_2 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000002482 137.0
HKD3_k127_1593072_3 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000000000002969 117.0
HKD3_k127_1647236_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.366e-281 872.0
HKD3_k127_1647236_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 566.0
HKD3_k127_1647236_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000001286 216.0
HKD3_k127_1647236_3 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.0000000000000000000000000000000000000000001248 168.0
HKD3_k127_1647236_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000003602 141.0
HKD3_k127_1663767_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 6.46e-310 961.0
HKD3_k127_1663767_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 584.0
HKD3_k127_1663767_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 399.0
HKD3_k127_1663767_3 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000003194 93.0
HKD3_k127_1663781_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007107 556.0
HKD3_k127_1663781_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000001232 94.0
HKD3_k127_1705596_0 - - - - 0.000000000000000000000000000000000000000000007037 167.0
HKD3_k127_1705596_1 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000005412 108.0
HKD3_k127_1705596_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000164 107.0
HKD3_k127_1705596_3 SigmaK-factor processing regulatory protein BofA K06317 - - 0.000000000000000003708 88.0
HKD3_k127_1705596_4 - - - - 0.0000000000000002848 85.0
HKD3_k127_1711194_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 408.0
HKD3_k127_1711194_1 ATP-grasp domain K06914 - 6.3.4.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 357.0
HKD3_k127_1711194_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 322.0
HKD3_k127_1711194_3 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000007453 261.0
HKD3_k127_1711194_4 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000000000001305 189.0
HKD3_k127_1711194_5 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000117 96.0
HKD3_k127_1711194_6 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000184 78.0
HKD3_k127_1773057_0 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002764 244.0
HKD3_k127_1773057_1 - - - - 0.00000000000000000000000000000000000000000001903 174.0
HKD3_k127_1773057_2 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.00000000000000000000000000000000000000006141 156.0
HKD3_k127_1773057_3 Citrate transporter - - - 0.000000000000000000000000002836 112.0
HKD3_k127_1792690_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 538.0
HKD3_k127_1792690_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 393.0
HKD3_k127_1792690_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000005713 257.0
HKD3_k127_1792690_3 - K06868 - 2.5.1.73 0.000000006422 61.0
HKD3_k127_1794212_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001131 274.0
HKD3_k127_1794212_1 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000003983 133.0
HKD3_k127_1821380_0 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 327.0
HKD3_k127_1821380_1 membrane-associated protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 267.0
HKD3_k127_1821380_2 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000001282 93.0
HKD3_k127_1821380_3 - - - - 0.00000000002101 74.0
HKD3_k127_1823420_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 406.0
HKD3_k127_1823420_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000003125 213.0
HKD3_k127_1823420_2 Small multi-drug export protein - - - 0.000000000000000000000000000000000000003666 154.0
HKD3_k127_1823420_4 Extradiol ring-cleavage dioxygenase K15777 - - 0.0000000000009899 68.0
HKD3_k127_1823420_5 Domain of unknown function (DUF3821) - - - 0.00001003 51.0
HKD3_k127_1856097_0 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 378.0
HKD3_k127_1856097_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 371.0
HKD3_k127_1856097_2 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009596 301.0
HKD3_k127_1892335_0 Predicted membrane protein (DUF2070) K08979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 426.0
HKD3_k127_1901645_0 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 1.34e-207 662.0
HKD3_k127_1901645_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 505.0
HKD3_k127_1901645_2 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 389.0
HKD3_k127_1901645_3 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
HKD3_k127_1901645_4 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000008662 78.0
HKD3_k127_1980192_0 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 401.0
HKD3_k127_1980192_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 359.0
HKD3_k127_1980192_2 PFAM Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000012 289.0
HKD3_k127_1980192_3 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000002546 195.0
HKD3_k127_201290_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 507.0
HKD3_k127_201290_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 501.0
HKD3_k127_2088535_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 420.0
HKD3_k127_2088535_1 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005533 378.0
HKD3_k127_2088535_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 310.0
HKD3_k127_2088535_3 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000003964 173.0
HKD3_k127_2088535_4 - - - - 0.000000000000000000000000000000003685 130.0
HKD3_k127_2088535_5 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000003974 73.0
HKD3_k127_2088535_6 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000008379 72.0
HKD3_k127_2088535_7 KH, type 1, domain K07041 - - 0.000002725 49.0
HKD3_k127_213120_0 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 556.0
HKD3_k127_213120_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 416.0
HKD3_k127_213120_2 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000006205 83.0
HKD3_k127_213120_3 - - - - 0.000000000000000006789 87.0
HKD3_k127_213120_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000008948 51.0
HKD3_k127_2205_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.037e-275 855.0
HKD3_k127_2205_1 phosphohydrolase (DHH superfamily) K07097 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004594 248.0
HKD3_k127_2205_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000009215 237.0
HKD3_k127_2251421_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 486.0
HKD3_k127_2251421_1 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 479.0
HKD3_k127_2251421_2 PFAM coenzyme PQQ synthesis - - - 0.00000000000000000000000000000418 121.0
HKD3_k127_2265901_0 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 581.0
HKD3_k127_2265901_1 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001401 258.0
HKD3_k127_2265901_2 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000001318 154.0
HKD3_k127_2275909_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.27e-243 772.0
HKD3_k127_2323016_0 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 6.8e-232 725.0
HKD3_k127_2323016_1 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 412.0
HKD3_k127_2323016_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 363.0
HKD3_k127_241408_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 405.0
HKD3_k127_241408_1 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 379.0
HKD3_k127_241408_2 Cyclophilin-like K09143 - - 0.000000000000000000000000000000726 125.0
HKD3_k127_2416363_0 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 3.936e-197 630.0
HKD3_k127_2416363_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007222 369.0
HKD3_k127_2416363_2 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 332.0
HKD3_k127_2416363_3 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003263 272.0
HKD3_k127_2416363_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000001798 117.0
HKD3_k127_2418675_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.945e-242 754.0
HKD3_k127_2418675_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 457.0
HKD3_k127_2418675_2 acid binding OB-fold tRNA helicase-type K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 380.0
HKD3_k127_2418675_3 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 346.0
HKD3_k127_2418675_4 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 284.0
HKD3_k127_2418675_5 adenyl ribonucleotide binding - - - 0.000000000000000000000000000000000000008183 160.0
HKD3_k127_242124_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 299.0
HKD3_k127_242124_1 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002448 284.0
HKD3_k127_242124_2 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000003774 207.0
HKD3_k127_2428127_0 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 528.0
HKD3_k127_2428127_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000005875 254.0
HKD3_k127_243776_0 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009169 317.0
HKD3_k127_243776_1 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001823 280.0
HKD3_k127_243776_2 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000009644 230.0
HKD3_k127_243776_3 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000005822 194.0
HKD3_k127_2455566_0 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 426.0
HKD3_k127_2455566_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003558 282.0
HKD3_k127_2455566_2 Oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002315 256.0
HKD3_k127_2455566_3 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000732 134.0
HKD3_k127_2503681_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 592.0
HKD3_k127_2503681_1 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000001117 211.0
HKD3_k127_2503681_2 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000000000005188 165.0
HKD3_k127_2531186_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 481.0
HKD3_k127_2531186_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 340.0
HKD3_k127_2531186_2 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 317.0
HKD3_k127_2531186_3 - - - - 0.000000000000000000000000000000000000000000000136 173.0
HKD3_k127_2537737_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 511.0
HKD3_k127_2537737_1 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 316.0
HKD3_k127_2537737_2 Transcriptional regulator K07108 - - 0.00000000000000000000000000000002696 128.0
HKD3_k127_2537737_3 Elongator protein 3 MiaB NifB - - - 0.00000000000319 66.0
HKD3_k127_2538978_0 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 355.0
HKD3_k127_2538978_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 289.0
HKD3_k127_2538978_2 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 283.0
HKD3_k127_2538978_3 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004952 262.0
HKD3_k127_2538978_4 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000005325 195.0
HKD3_k127_2538978_5 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000005393 163.0
HKD3_k127_2538978_6 Zinc-ribbon containing domain - - - 0.00000000000000000000000000003777 118.0
HKD3_k127_2538978_7 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000007679 76.0
HKD3_k127_2551527_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 3.652e-206 650.0
HKD3_k127_2551527_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000003431 169.0
HKD3_k127_2551527_2 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000001649 90.0
HKD3_k127_2560843_0 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 359.0
HKD3_k127_2560843_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 319.0
HKD3_k127_2560843_2 PFAM ribosomal protein S8E K02995 - - 0.00000000000000000000000000000000000000000000005185 172.0
HKD3_k127_2560843_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000364 175.0
HKD3_k127_2560843_4 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.0000000000000000000000000000000000000001129 157.0
HKD3_k127_2560843_5 - - - - 0.000000000000000000000000000000000008151 145.0
HKD3_k127_2564546_0 PFAM ferredoxin-dependent glutamate synthase - - - 5.811e-295 910.0
HKD3_k127_2564546_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 584.0
HKD3_k127_2564546_2 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 379.0
HKD3_k127_2564546_3 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000382 188.0
HKD3_k127_2564546_4 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000718 153.0
HKD3_k127_2656805_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 374.0
HKD3_k127_2656805_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000003347 160.0
HKD3_k127_2667066_0 Cobalt transport protein K02008 - - 0.000000000000000000000000000000000000000000000000000000004954 209.0
HKD3_k127_2667066_1 iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000003049 172.0
HKD3_k127_2667066_2 ATPases associated with a variety of cellular activities K02006 - - 0.0000000000000000000000000001574 119.0
HKD3_k127_2667066_3 - - - - 0.0007204 44.0
HKD3_k127_2683184_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1217.0
HKD3_k127_2683184_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 293.0
HKD3_k127_2683184_2 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000009116 96.0
HKD3_k127_2683184_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000004593 76.0
HKD3_k127_2698103_0 Belongs to the glutamate synthase family - - - 1.799e-276 855.0
HKD3_k127_2698103_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 569.0
HKD3_k127_2698103_2 PFAM glutamine amidotransferase, class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 562.0
HKD3_k127_2698103_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 403.0
HKD3_k127_2698103_4 PFAM glutamate synthase alpha subunit domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 349.0
HKD3_k127_2703788_0 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 454.0
HKD3_k127_2703788_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 336.0
HKD3_k127_2703788_2 PDGLE domain K02009 - - 0.00000000000000000000007045 105.0
HKD3_k127_2703788_3 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000001475 84.0
HKD3_k127_2709284_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 449.0
HKD3_k127_2709284_1 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000000000000007887 207.0
HKD3_k127_2709284_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000005504 189.0
HKD3_k127_2709284_3 - - - - 0.000000561 62.0
HKD3_k127_2713516_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 294.0
HKD3_k127_2713516_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006548 246.0
HKD3_k127_2713516_2 COG2041 Sulfite oxidase and related enzymes K02016 - - 0.0000000000000000000000000000000000000000000005369 175.0
HKD3_k127_2713516_3 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000007335 183.0
HKD3_k127_2714859_0 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 481.0
HKD3_k127_2714859_1 - - - - 0.00000000000009037 82.0
HKD3_k127_2714859_2 tetratricopeptide repeat - - - 0.0002762 46.0
HKD3_k127_2766287_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 475.0
HKD3_k127_2766287_1 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 306.0
HKD3_k127_2766287_2 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000009407 190.0
HKD3_k127_2766287_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000002475 138.0
HKD3_k127_2771691_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.0 1114.0
HKD3_k127_2771691_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.00000000000000000000000000000000000000000000000000001515 194.0
HKD3_k127_2771691_2 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000003742 158.0
HKD3_k127_2771691_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000005829 68.0
HKD3_k127_2780463_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 2.794e-262 821.0
HKD3_k127_280632_0 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 329.0
HKD3_k127_280632_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 303.0
HKD3_k127_280632_2 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000001215 237.0
HKD3_k127_280632_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000001041 229.0
HKD3_k127_280632_4 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000001962 191.0
HKD3_k127_2822361_0 ATP-grasp domain K06913 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 383.0
HKD3_k127_2822361_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000001934 246.0
HKD3_k127_2822361_2 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000004449 226.0
HKD3_k127_2822361_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.000000000000000000000000000000000000000000005717 168.0
HKD3_k127_2835552_0 nucleoside 2-deoxyribosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 305.0
HKD3_k127_2835552_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000002346 263.0
HKD3_k127_2835552_2 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000003138 237.0
HKD3_k127_2835552_3 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.00000000000000000000000000000000000000002639 160.0
HKD3_k127_2863804_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 571.0
HKD3_k127_2863804_1 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 316.0
HKD3_k127_2863804_2 - - - - 0.000000000000000000001009 107.0
HKD3_k127_2871183_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 310.0
HKD3_k127_2871183_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000003073 220.0
HKD3_k127_2871183_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000007795 226.0
HKD3_k127_2871183_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000003889 210.0
HKD3_k127_2871183_4 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.000000000000000000000005309 102.0
HKD3_k127_2871183_5 PFAM Ribosomal protein K02912 - - 0.00000000000000000002214 98.0
HKD3_k127_2902392_0 PFAM ABC-1 domain protein K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 509.0
HKD3_k127_2902392_1 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000006165 174.0
HKD3_k127_2902392_2 - - - - 0.0000000000000000000000000000009292 126.0
HKD3_k127_2933025_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 5.742e-218 683.0
HKD3_k127_2933025_1 domain, Protein K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 554.0
HKD3_k127_2933025_10 - - - - 0.0000005678 57.0
HKD3_k127_2933025_2 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 547.0
HKD3_k127_2933025_3 PFAM proteinase inhibitor I4 serpin K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 484.0
HKD3_k127_2933025_4 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 349.0
HKD3_k127_2933025_5 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001006 257.0
HKD3_k127_2933025_6 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000004637 227.0
HKD3_k127_2933025_7 - - - - 0.0000000000000000001877 95.0
HKD3_k127_2933025_8 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000148 83.0
HKD3_k127_2933025_9 endonuclease III K01247 - 3.2.2.21 0.00000001941 65.0
HKD3_k127_2961900_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.101e-246 773.0
HKD3_k127_2961900_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 481.0
HKD3_k127_2961900_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 445.0
HKD3_k127_2961900_3 transferase hexapeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000253 236.0
HKD3_k127_2963446_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 598.0
HKD3_k127_2963446_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 351.0
HKD3_k127_2963446_2 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 310.0
HKD3_k127_2963446_3 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 272.0
HKD3_k127_2963446_4 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004877 261.0
HKD3_k127_2963446_5 - - - - 0.000006434 48.0
HKD3_k127_2963446_6 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00004694 49.0
HKD3_k127_2988525_0 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000719 325.0
HKD3_k127_2988525_1 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002307 267.0
HKD3_k127_2988525_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000004145 213.0
HKD3_k127_2988525_3 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.00000000000000000004867 100.0
HKD3_k127_3027586_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 457.0
HKD3_k127_3027586_1 Domain of unknown function (DUF4445) - - - 0.00002976 46.0
HKD3_k127_304240_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.032e-194 615.0
HKD3_k127_304240_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 439.0
HKD3_k127_304240_2 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 360.0
HKD3_k127_304240_3 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000004187 177.0
HKD3_k127_304240_4 - - - - 0.0000000000000000000000000000000007867 139.0
HKD3_k127_3079267_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000001174 129.0
HKD3_k127_3100520_0 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 447.0
HKD3_k127_3100520_1 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000001578 212.0
HKD3_k127_3100520_2 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000005951 175.0
HKD3_k127_3100520_3 Belongs to the UPF0305 family - - - 0.00000000000000000000000000000000000000000000000599 180.0
HKD3_k127_3129427_0 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 323.0
HKD3_k127_3129427_1 FeS cluster assembly scaffold protein NifU K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000006114 231.0
HKD3_k127_3129427_2 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000000000006589 151.0
HKD3_k127_3129427_3 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000004632 95.0
HKD3_k127_3132275_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002182 246.0
HKD3_k127_3132275_1 Two component regulator propeller K00936 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001432 195.0
HKD3_k127_3183624_0 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 312.0
HKD3_k127_3183624_1 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 299.0
HKD3_k127_3183624_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000006068 192.0
HKD3_k127_3284361_0 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000001444 153.0
HKD3_k127_3284361_1 Methyltransferase K15429 - 2.1.1.228 0.000000000006455 67.0
HKD3_k127_3389496_0 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 445.0
HKD3_k127_3389496_1 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 322.0
HKD3_k127_3389496_2 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 308.0
HKD3_k127_3389496_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000366 191.0
HKD3_k127_3389496_4 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000008464 78.0
HKD3_k127_3457437_0 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 513.0
HKD3_k127_3457437_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 289.0
HKD3_k127_3457437_2 PFAM HhH-GPD family protein K07457 - - 0.00000000000000000000000000000000000000000000000000000000000811 216.0
HKD3_k127_3457437_3 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000002817 164.0
HKD3_k127_3457437_4 PFAM Thioredoxin K03671 - - 0.000000000000000000000000000000000001878 141.0
HKD3_k127_3457437_5 Transcriptional regulator K07729 - - 0.00000000000000000000001162 104.0
HKD3_k127_3457437_7 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000009793 48.0
HKD3_k127_3564662_0 TIGRFAM MIP family channel K02440,K06188 - - 0.00000000000000000005255 89.0
HKD3_k127_3564662_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000002747 61.0
HKD3_k127_3564662_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000004314 55.0
HKD3_k127_3630785_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 3.312e-305 949.0
HKD3_k127_3630785_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 572.0
HKD3_k127_3630785_2 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 471.0
HKD3_k127_3630785_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 340.0
HKD3_k127_3630785_4 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 321.0
HKD3_k127_3630785_5 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 309.0
HKD3_k127_3630785_6 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000001769 177.0
HKD3_k127_3632703_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 490.0
HKD3_k127_3632703_1 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 366.0
HKD3_k127_3632703_2 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 349.0
HKD3_k127_3632703_3 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000001122 151.0
HKD3_k127_3632703_4 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000000000001271 137.0
HKD3_k127_3632703_5 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000001595 106.0
HKD3_k127_3656823_0 PFAM cyclase family protein K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000006093 204.0
HKD3_k127_3656823_1 - - - - 0.00000000000000000000000000000000000000000003702 169.0
HKD3_k127_3656823_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000000000000000000000001153 136.0
HKD3_k127_3656823_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000003495 87.0
HKD3_k127_3661906_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 5.427e-247 786.0
HKD3_k127_3668586_0 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 348.0
HKD3_k127_3668586_1 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000001255 155.0
HKD3_k127_3668586_2 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000001008 153.0
HKD3_k127_3668586_3 HEPN domain - - - 0.0000009179 55.0
HKD3_k127_3683073_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 583.0
HKD3_k127_3683073_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 526.0
HKD3_k127_3683073_2 Tetratricopeptide repeat - - - 0.00002387 48.0
HKD3_k127_3692118_0 PFAM peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 454.0
HKD3_k127_3692118_1 RNA methylase K07446 - 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 336.0
HKD3_k127_3705862_0 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008257 315.0
HKD3_k127_3705862_1 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000000000000000000000000000000001819 192.0
HKD3_k127_3716333_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000004816 259.0
HKD3_k127_3716333_1 Cytochrome C biogenesis protein - - - 0.00000000000000000000000000043 130.0
HKD3_k127_3757261_0 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 309.0
HKD3_k127_3757261_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001047 259.0
HKD3_k127_3757261_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000007326 208.0
HKD3_k127_3757261_3 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000001195 126.0
HKD3_k127_3757261_4 Alpha/beta hydrolase family K06889 - - 0.0000000005691 63.0
HKD3_k127_3757261_5 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000005854 55.0
HKD3_k127_3770039_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.632e-236 740.0
HKD3_k127_3770039_1 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 569.0
HKD3_k127_3770039_2 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 430.0
HKD3_k127_3770039_3 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000003127 216.0
HKD3_k127_3770039_4 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000007966 214.0
HKD3_k127_3770039_5 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000002697 199.0
HKD3_k127_3770039_6 PFAM Phosphatidylglycerophosphatase A - - - 0.00000000000000000000000000000000000000000000000002678 190.0
HKD3_k127_3770039_7 - - - - 0.00000000000000000000000000000000000006111 145.0
HKD3_k127_3770861_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 466.0
HKD3_k127_3770861_1 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000687 295.0
HKD3_k127_3770861_2 protein conserved in archaea K09746 - - 0.000000000000000000000000000000277 143.0
HKD3_k127_3770861_3 PFAM metallophosphoesterase K06953 - - 0.00000000006576 63.0
HKD3_k127_3771664_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 4.324e-242 759.0
HKD3_k127_3771664_1 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 569.0
HKD3_k127_3771664_2 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000003873 258.0
HKD3_k127_3781907_0 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 307.0
HKD3_k127_3781907_1 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000000000000000002735 172.0
HKD3_k127_3782890_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 346.0
HKD3_k127_3782890_1 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000175 193.0
HKD3_k127_3782890_2 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000003544 106.0
HKD3_k127_3784059_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 439.0
HKD3_k127_3784059_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 325.0
HKD3_k127_3787458_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 526.0
HKD3_k127_3787458_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 300.0
HKD3_k127_3808574_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002263 275.0
HKD3_k127_3808574_1 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007922 248.0
HKD3_k127_3808574_2 - - - - 0.000000002038 59.0
HKD3_k127_3808574_3 - - - - 0.00000000436 65.0
HKD3_k127_3816685_0 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009723 355.0
HKD3_k127_3816685_1 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 312.0
HKD3_k127_3816685_2 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000001824 203.0
HKD3_k127_3816685_3 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000002156 136.0
HKD3_k127_3816685_4 COG1202 Superfamily II helicase, archaea-specific - - - 0.0000000000000000000000004102 106.0
HKD3_k127_3862595_0 AAA-like domain K06915 - - 2.53e-227 716.0
HKD3_k127_3862595_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.000000000000000000000000000000000000000000003543 169.0
HKD3_k127_3862595_2 PFAM formate nitrite transporter K21993 - - 0.000000000000000000000000000000000000002294 147.0
HKD3_k127_3880111_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 557.0
HKD3_k127_3880111_1 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0002688 44.0
HKD3_k127_3894179_0 COG2133 Glucose sorbosone dehydrogenases - - - 1.41e-226 730.0
HKD3_k127_3894179_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 527.0
HKD3_k127_3894179_10 Rieske-like [2Fe-2S] domain - - - 0.00000000000000006914 89.0
HKD3_k127_3894179_11 Proline dehydrogenase K00318 GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046983,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.00000000000000008064 93.0
HKD3_k127_3894179_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000002064 63.0
HKD3_k127_3894179_14 Heparinase II/III-like protein - - - 0.00001762 55.0
HKD3_k127_3894179_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 477.0
HKD3_k127_3894179_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003439 264.0
HKD3_k127_3894179_4 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005332 276.0
HKD3_k127_3894179_5 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000004011 151.0
HKD3_k127_3894179_6 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000003505 144.0
HKD3_k127_3894179_7 Protein of unknown function (DUF2769) - - - 0.0000000000000000000000000000000001085 135.0
HKD3_k127_3894179_8 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000001101 140.0
HKD3_k127_3894179_9 ATP cone domain - - - 0.000000000000000000000000004369 112.0
HKD3_k127_3916510_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1301.0
HKD3_k127_3916510_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 5.177e-227 713.0
HKD3_k127_3916510_10 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000001117 160.0
HKD3_k127_3916510_11 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000275 159.0
HKD3_k127_3916510_12 HEAT repeats - - - 0.00000000000000000000002633 106.0
HKD3_k127_3916510_2 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 388.0
HKD3_k127_3916510_3 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 322.0
HKD3_k127_3916510_4 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001199 272.0
HKD3_k127_3916510_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000928 226.0
HKD3_k127_3916510_6 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000000000000000000000000001003 195.0
HKD3_k127_3916510_7 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000361 197.0
HKD3_k127_3916510_8 PFAM SCP-like extracellular - - - 0.000000000000000000000000000000000000000000000003256 184.0
HKD3_k127_3916510_9 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000883 173.0
HKD3_k127_3922272_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 568.0
HKD3_k127_3922272_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 343.0
HKD3_k127_3922272_2 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 347.0
HKD3_k127_3922272_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000000006937 130.0
HKD3_k127_3922272_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000000229 91.0
HKD3_k127_3922272_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000001028 79.0
HKD3_k127_3922272_6 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000008096 76.0
HKD3_k127_3985458_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 374.0
HKD3_k127_3985458_1 PFAM methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 345.0
HKD3_k127_3985458_2 Methyltransferase K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006867 248.0
HKD3_k127_3985458_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000002957 239.0
HKD3_k127_3985458_4 - - - - 0.00000000000000000000000000000000000000000000000002298 195.0
HKD3_k127_3985458_5 Mannose-6-phosphate isomerase, type K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000003856 171.0
HKD3_k127_3985458_6 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000615 162.0
HKD3_k127_3985458_7 EamA-like transporter family - - - 0.00000000000000000001557 97.0
HKD3_k127_4002111_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 341.0
HKD3_k127_4002111_1 - - - - 0.00000000000000466 89.0
HKD3_k127_4019864_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 454.0
HKD3_k127_4019864_1 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000005104 246.0
HKD3_k127_4019864_2 - - - - 0.00000000000000000000000000000000000000000000000000003303 194.0
HKD3_k127_4021189_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 294.0
HKD3_k127_4021189_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001375 254.0
HKD3_k127_4026317_0 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 464.0
HKD3_k127_4026317_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 429.0
HKD3_k127_4026317_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002378 278.0
HKD3_k127_4026317_3 asparagine synthase - - - 0.0000000000002658 78.0
HKD3_k127_4041469_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 454.0
HKD3_k127_4041469_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 368.0
HKD3_k127_4041469_2 COG1361 S-layer domain - - - 0.0000001054 55.0
HKD3_k127_4059183_0 DEAD DEAH box helicase domain protein K03725 - - 1.824e-263 829.0
HKD3_k127_4059183_1 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000006236 218.0
HKD3_k127_413746_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 4.31e-215 679.0
HKD3_k127_413746_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 453.0
HKD3_k127_413746_2 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 364.0
HKD3_k127_413746_3 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000000000001051 177.0
HKD3_k127_413746_4 binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000000000000004906 171.0
HKD3_k127_413746_5 metal-binding protein - - - 0.0000000000000000000000001692 109.0
HKD3_k127_413746_6 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000000000005899 110.0
HKD3_k127_413746_7 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000000000002318 74.0
HKD3_k127_4171374_0 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 580.0
HKD3_k127_4171374_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 553.0
HKD3_k127_4171374_2 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 331.0
HKD3_k127_4171374_3 Protein phosphatase 2C - - - 0.00000000000000000000000000000000000000000000000000000000000000000002226 242.0
HKD3_k127_4171374_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000004056 222.0
HKD3_k127_4171374_5 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000002871 207.0
HKD3_k127_4171374_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000008229 89.0
HKD3_k127_4171374_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000000000007386 84.0
HKD3_k127_4171374_8 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000135 73.0
HKD3_k127_4176712_0 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 372.0
HKD3_k127_4176712_1 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 321.0
HKD3_k127_4176712_2 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000004651 216.0
HKD3_k127_4210690_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 569.0
HKD3_k127_4210690_1 - - - - 0.0000000000000000000000000006427 126.0
HKD3_k127_4213594_0 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 490.0
HKD3_k127_4213594_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 438.0
HKD3_k127_4213594_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.0000000000000000000000000000000000000000000000000608 188.0
HKD3_k127_4213594_3 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000005553 142.0
HKD3_k127_4257017_0 KH, type 1, domain K07041 - - 0.0 1085.0
HKD3_k127_4257017_1 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 330.0
HKD3_k127_4260370_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003435 460.0
HKD3_k127_4260370_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007174 374.0
HKD3_k127_4260370_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000599 232.0
HKD3_k127_4260370_3 protein conserved in archaea - - - 0.00000000000000000000000000004244 119.0
HKD3_k127_4260370_4 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000002328 87.0
HKD3_k127_4260370_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000002877 88.0
HKD3_k127_4260370_6 - - - - 0.0003371 47.0
HKD3_k127_4390732_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 286.0
HKD3_k127_4390732_1 membrane K09167 - - 0.00000000000000000000000000000000000000000000000000000000000007374 218.0
HKD3_k127_4444880_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 412.0
HKD3_k127_4444880_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000005158 108.0
HKD3_k127_4444880_2 Protein of unknown function DUF116 K09729 - - 0.00000004219 60.0
HKD3_k127_4448417_0 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 460.0
HKD3_k127_4448417_1 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008792 280.0
HKD3_k127_4448417_2 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000009846 205.0
HKD3_k127_4448417_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000001592 184.0
HKD3_k127_4460400_0 Domain of unknown function DUF87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 379.0
HKD3_k127_4460400_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 358.0
HKD3_k127_4493544_0 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000001203 131.0
HKD3_k127_4493544_1 signal transduction protein with CBS domains - - - 0.0000000000000000002299 98.0
HKD3_k127_4493544_2 - - - - 0.00000000000000215 79.0
HKD3_k127_4493544_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000003183 79.0
HKD3_k127_4493544_4 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000325 59.0
HKD3_k127_4509599_0 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 315.0
HKD3_k127_4509599_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000003926 223.0
HKD3_k127_4509599_2 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000000000001956 173.0
HKD3_k127_4519121_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 520.0
HKD3_k127_4519121_1 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 454.0
HKD3_k127_4519121_2 PFAM N-acetylneuraminic acid synthase K01654,K18430 - 2.5.1.101,2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 313.0
HKD3_k127_4519121_3 MviN-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001018 284.0
HKD3_k127_4519121_4 PFAM acylneuraminate cytidylyltransferase K00983 - 2.7.7.43 0.00000000000000000000000000000000000000000000000000000000000000000004509 241.0
HKD3_k127_4519121_5 Putative small multi-drug export protein - - - 0.00000000000000000000000000001179 122.0
HKD3_k127_4582697_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 527.0
HKD3_k127_4582697_1 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003504 246.0
HKD3_k127_4582697_2 Belongs to the UPF0146 family K09713 - - 0.00000000000000000000002349 100.0
HKD3_k127_4621082_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 407.0
HKD3_k127_4621082_1 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000000001854 211.0
HKD3_k127_4621082_2 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000001439 141.0
HKD3_k127_4621082_3 PFAM ABC transporter, ATPase K06924 - - 0.00000000000000002255 88.0
HKD3_k127_4642132_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 4.173e-226 710.0
HKD3_k127_4642132_1 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000002669 232.0
HKD3_k127_4642132_2 - - - - 0.000000000000000000000000000000000000000000003279 175.0
HKD3_k127_4642132_3 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.000000000000000000000008777 108.0
HKD3_k127_47304_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 319.0
HKD3_k127_47304_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000007917 246.0
HKD3_k127_47304_2 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000005075 164.0
HKD3_k127_47304_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000000009918 89.0
HKD3_k127_4794236_0 B-block binding subunit of TFIIIC - - - 0.000000000000000000000000000000000000000000002162 166.0
HKD3_k127_4794236_1 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000001306 129.0
HKD3_k127_4794236_2 PFAM periplasmic binding protein K02016 - - 0.00000000000000000001469 96.0
HKD3_k127_4794236_3 - - - - 0.0000000000000001415 89.0
HKD3_k127_4824443_0 Rhodanese-like domain K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 462.0
HKD3_k127_4900984_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 520.0
HKD3_k127_4900984_1 TIGRFAM UbiD family - - - 0.000000000000000000000000000000008896 128.0
HKD3_k127_4911164_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006036 276.0
HKD3_k127_4911164_1 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000004402 245.0
HKD3_k127_4911164_2 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000001859 100.0
HKD3_k127_4911164_3 PFAM PP-loop domain protein - - - 0.00004407 50.0
HKD3_k127_4911559_0 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001703 245.0
HKD3_k127_4911559_1 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000000000001414 176.0
HKD3_k127_4911559_2 Family of unknown function (DUF5350) - - - 0.00000000000000000000002668 106.0
HKD3_k127_4911559_3 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000002745 87.0
HKD3_k127_4913863_0 COG0306 Phosphate sulphate permeases K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 364.0
HKD3_k127_4913863_1 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003132 246.0
HKD3_k127_4913863_2 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000001279 190.0
HKD3_k127_4913863_3 - - - - 0.00000000000001301 81.0
HKD3_k127_4913863_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.00000000002738 67.0
HKD3_k127_4913863_5 Protein of unknown function (DUF998) - - - 0.0000003475 60.0
HKD3_k127_4913863_6 - - - - 0.0000003688 59.0
HKD3_k127_4923798_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 6.799e-223 703.0
HKD3_k127_4923798_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 4.471e-194 625.0
HKD3_k127_4928525_0 Belongs to the glutamate synthase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 588.0
HKD3_k127_4928525_1 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 362.0
HKD3_k127_4928525_2 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000003309 190.0
HKD3_k127_4928525_3 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000002732 184.0
HKD3_k127_4928525_4 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000003921 153.0
HKD3_k127_4928525_5 - - - - 0.0000000000001659 74.0
HKD3_k127_4982946_0 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 519.0
HKD3_k127_4982946_1 PFAM Glycosyl transferase family 2 K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 355.0
HKD3_k127_4982946_2 Involved in cell shape control K22222 - - 0.000000000000000000000000000000000000000000000004158 175.0
HKD3_k127_4982946_3 COG0463 Glycosyltransferases involved in cell wall biogenesis K07027 - - 0.0000000000000006306 82.0
HKD3_k127_4987890_0 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases K00467 - 1.13.12.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 432.0
HKD3_k127_4987890_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 368.0
HKD3_k127_4987890_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000008595 152.0
HKD3_k127_5004024_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 1.52e-254 790.0
HKD3_k127_5004024_1 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 552.0
HKD3_k127_5004024_2 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 486.0
HKD3_k127_5004024_3 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.0000000001157 63.0
HKD3_k127_5028065_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.348e-208 657.0
HKD3_k127_5028065_1 PFAM Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 569.0
HKD3_k127_5028065_2 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000011 228.0
HKD3_k127_5028065_3 Thioredoxin K03671 - - 0.00000000000000000000000000000000000001406 149.0
HKD3_k127_5028065_4 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000001772 111.0
HKD3_k127_5044805_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1144.0
HKD3_k127_5044805_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.895e-206 649.0
HKD3_k127_5044805_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000004809 224.0
HKD3_k127_5044805_3 chromosome segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000000004755 156.0
HKD3_k127_5044805_4 - - - - 0.0000000000000003712 83.0
HKD3_k127_5064467_0 SMART Elongator protein 3 MiaB NifB - - - 1.187e-232 732.0
HKD3_k127_5064467_1 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000002081 251.0
HKD3_k127_5064467_2 phosphoesterase RecJ domain protein - - - 0.000000000000000000000000000000000000000000001083 167.0
HKD3_k127_5064467_3 Belongs to the peptidase M50B family - - - 0.00000000007693 63.0
HKD3_k127_5085225_0 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 358.0
HKD3_k127_5085225_1 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005398 295.0
HKD3_k127_5085225_2 COG1437 Adenylate cyclase, class 2 (thermophilic) K05873 - 4.6.1.1 0.000001669 53.0
HKD3_k127_5095677_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 383.0
HKD3_k127_5095677_1 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002036 269.0
HKD3_k127_5095677_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000008821 157.0
HKD3_k127_5115299_0 Domain of unknown function (DUF4349) - - - 0.00000000000000000000000000000000000000000000000000002611 193.0
HKD3_k127_5115299_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000004253 145.0
HKD3_k127_5176024_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 612.0
HKD3_k127_5176024_1 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000004108 104.0
HKD3_k127_5176024_2 TIR domain - - - 0.0000000000000000000000161 108.0
HKD3_k127_5176024_3 TIR domain - - - 0.0000000000000000000003027 103.0
HKD3_k127_5176024_4 PFAM NHL repeat containing protein - - - 0.000000000000000000004251 101.0
HKD3_k127_5230900_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 440.0
HKD3_k127_5230900_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 360.0
HKD3_k127_5230900_2 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000001813 237.0
HKD3_k127_5230900_3 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.00000000000000000000000000000000000000000000000000000000000001792 220.0
HKD3_k127_5230900_4 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000000002743 221.0
HKD3_k127_5230900_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000005986 93.0
HKD3_k127_5230900_6 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000003645 91.0
HKD3_k127_5243623_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 1.583e-197 623.0
HKD3_k127_5243623_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 297.0
HKD3_k127_5243623_2 assists the folding of proteins upon ATP hydrolysis K09499 - - 0.00000002635 55.0
HKD3_k127_5243623_3 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.0002061 44.0
HKD3_k127_5249816_0 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000601 350.0
HKD3_k127_5249816_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000631 318.0
HKD3_k127_5249816_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 299.0
HKD3_k127_5249816_3 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006552 275.0
HKD3_k127_5296941_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 414.0
HKD3_k127_5296941_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 377.0
HKD3_k127_5343727_0 Belongs to the RtcB family K14415 - 6.5.1.3 1.573e-216 680.0
HKD3_k127_5343727_1 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 294.0
HKD3_k127_5343727_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000001576 232.0
HKD3_k127_5343727_3 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000002377 202.0
HKD3_k127_5343727_4 - - - - 0.00000000000000000000000002487 111.0
HKD3_k127_5343727_5 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000186 106.0
HKD3_k127_5343727_6 Protein of unknown function (DUF2551) - - - 0.0000000000000000000003111 101.0
HKD3_k127_5343727_7 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000136 90.0
HKD3_k127_535507_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 4.845e-212 676.0
HKD3_k127_535507_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000001776 233.0
HKD3_k127_535507_2 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000002882 170.0
HKD3_k127_535507_3 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00000000000000000000000000000001355 135.0
HKD3_k127_535507_4 - - - - 0.00000000006575 68.0
HKD3_k127_5357863_0 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 345.0
HKD3_k127_5357863_1 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000000000000000000000000000000000001433 235.0
HKD3_k127_5357863_2 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000000000000007344 199.0
HKD3_k127_5357863_3 Prokaryotic homologs of the JAB domain - - - 0.000000000000000000000000000000000000001099 151.0
HKD3_k127_5357863_4 PFAM von Willebrand factor type A - - - 0.00000000000000000000004797 114.0
HKD3_k127_5399499_0 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 492.0
HKD3_k127_5399499_1 Pectate lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 320.0
HKD3_k127_5399499_2 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000002566 193.0
HKD3_k127_5399499_3 - - - - 0.00000000000000000000000000000000000000000003183 171.0
HKD3_k127_5399499_4 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000003259 71.0
HKD3_k127_5418448_0 PFAM type II secretion system protein E K07332 - - 1.503e-276 865.0
HKD3_k127_5418448_1 type II secretion system protein K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 422.0
HKD3_k127_5418448_2 KaiC K07331 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 381.0
HKD3_k127_5418448_3 - - - - 0.00000000000000000000000000000000000000000000003538 179.0
HKD3_k127_5418448_4 Archaebacterial flagellin K07330 - - 0.000000000000000000000000000000008033 132.0
HKD3_k127_5418448_5 Archaeal flagellar protein F K07329 - - 0.000000000000000000000009045 106.0
HKD3_k127_5433524_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1111.0
HKD3_k127_5433524_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 520.0
HKD3_k127_5433524_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 504.0
HKD3_k127_5433524_3 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 410.0
HKD3_k127_5433524_4 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000009809 264.0
HKD3_k127_5433524_5 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000000000000007434 226.0
HKD3_k127_5469774_0 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 418.0
HKD3_k127_5469774_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000004136 237.0
HKD3_k127_5469774_2 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000003682 210.0
HKD3_k127_5469774_3 - - - - 0.000000000000000000000000000001499 128.0
HKD3_k127_5469774_4 acetylornithine and succinylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.0000000000000000000000001659 110.0
HKD3_k127_5496130_0 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 386.0
HKD3_k127_5496130_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000001597 176.0
HKD3_k127_5496130_2 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000001988 177.0
HKD3_k127_5496130_3 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000002093 168.0
HKD3_k127_5496130_4 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000000000000000000003848 143.0
HKD3_k127_5496130_5 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000001635 123.0
HKD3_k127_5505624_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 431.0
HKD3_k127_5505624_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000001859 252.0
HKD3_k127_5505624_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000004382 185.0
HKD3_k127_5520021_0 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 629.0
HKD3_k127_5520021_1 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009174 473.0
HKD3_k127_5520021_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0001577 49.0
HKD3_k127_5521060_0 Fumarate reductase succinate dehydrogenase flavoprotein K00239 - 1.3.5.1,1.3.5.4 1.81e-255 799.0
HKD3_k127_5521060_1 Fumarase C C-terminus K01679,K01744 - 4.2.1.2,4.3.1.1 3.94e-196 627.0
HKD3_k127_5521060_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 487.0
HKD3_k127_5521060_3 COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 334.0
HKD3_k127_5521060_4 Extradiol ring-cleavage dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000518 296.0
HKD3_k127_5521060_5 Membrane - - - 0.000000000000000000000000000000000000000000000000000000002891 213.0
HKD3_k127_5537180_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 6.111e-208 657.0
HKD3_k127_5547047_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 1.072e-249 792.0
HKD3_k127_5547047_1 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 437.0
HKD3_k127_5547047_2 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000001913 196.0
HKD3_k127_5547047_3 Domain of unknown function (DUF4962) - - - 0.0000000000000000000000000000001174 144.0
HKD3_k127_5547047_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000007344 71.0
HKD3_k127_5558799_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 423.0
HKD3_k127_5558799_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 356.0
HKD3_k127_5558799_2 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000002814 196.0
HKD3_k127_5558799_3 transporter K07238,K11021 - - 0.0000000000000000000000000000000005408 139.0
HKD3_k127_5620690_0 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 353.0
HKD3_k127_5620690_1 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 302.0
HKD3_k127_5620690_2 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000005063 142.0
HKD3_k127_5629251_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000001597 264.0
HKD3_k127_5629251_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000006547 214.0
HKD3_k127_5629251_2 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000000000000000000000000000000000000000699 206.0
HKD3_k127_5629251_3 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000000000000002732 190.0
HKD3_k127_5674349_0 DEAD DEAH box helicase domain protein K10896 - - 6.408e-306 957.0
HKD3_k127_5674349_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 523.0
HKD3_k127_5735005_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000002948 226.0
HKD3_k127_5735005_1 MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000001683 226.0
HKD3_k127_5851275_0 PFAM Transketolase domain protein K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006713 353.0
HKD3_k127_5851275_1 Transketolase, central region K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 352.0
HKD3_k127_5851275_10 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.00000000000000000000001539 113.0
HKD3_k127_5851275_12 Acetyltransferase (isoleucine patch K00661 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.79 0.0000000000000000000001864 104.0
HKD3_k127_5851275_13 - - - - 0.0000000000000000000363 106.0
HKD3_k127_5851275_14 Methyltransferase domain - - - 0.0000000000000000000537 93.0
HKD3_k127_5851275_15 - - - - 0.00000000000132 76.0
HKD3_k127_5851275_2 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 329.0
HKD3_k127_5851275_3 4-phosphoerythronate dehydrogenase activity K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 307.0
HKD3_k127_5851275_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 286.0
HKD3_k127_5851275_5 PFAM acylneuraminate cytidylyltransferase K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006378 271.0
HKD3_k127_5851275_6 Belongs to the HpcH HpaI aldolase family K01630 - 4.1.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000009904 264.0
HKD3_k127_5851275_7 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000003237 228.0
HKD3_k127_5851275_8 SIS domain K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000006918 187.0
HKD3_k127_5851275_9 glycolate biosynthetic process K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000004257 173.0
HKD3_k127_5888777_0 neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 363.0
HKD3_k127_5888777_1 - - - - 0.000000004585 63.0
HKD3_k127_590332_0 signal transduction protein with CBS domains K07744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 407.0
HKD3_k127_590332_1 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000007142 244.0
HKD3_k127_590332_2 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000006719 79.0
HKD3_k127_590332_3 Histone-like transcription factor (CBF/NF-Y) and archaeal histone - - - 0.0000000000000373 82.0
HKD3_k127_590332_4 PRC-barrel domain - - - 0.00000000000322 69.0
HKD3_k127_598183_0 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 306.0
HKD3_k127_598183_1 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000006009 224.0
HKD3_k127_598183_2 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000000000000000000000000004982 177.0
HKD3_k127_598183_3 - - - - 0.000000000000000000001097 100.0
HKD3_k127_598183_4 Protein of unknown function (DUF4013) - - - 0.00000000000000000000313 104.0
HKD3_k127_6059620_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
HKD3_k127_6059620_1 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 346.0
HKD3_k127_6059620_2 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 317.0
HKD3_k127_6059620_3 - - - - 0.000000000000000000000000007026 116.0
HKD3_k127_6060062_0 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 588.0
HKD3_k127_6060062_1 Trypsin - - - 0.0000000000000000000000000000000001095 136.0
HKD3_k127_6060062_2 Belongs to the UPF0248 family K09715 - - 0.00002329 52.0
HKD3_k127_6074183_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 412.0
HKD3_k127_6074183_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007822 252.0
HKD3_k127_6074183_2 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000001189 242.0
HKD3_k127_6074183_3 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000001568 228.0
HKD3_k127_6074183_4 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000000000000001638 158.0
HKD3_k127_6074183_5 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000002291 113.0
HKD3_k127_6119367_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 2.36e-196 622.0
HKD3_k127_6119367_1 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 468.0
HKD3_k127_6119367_2 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 435.0
HKD3_k127_6119367_3 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000193 216.0
HKD3_k127_6119367_4 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000000000000006577 206.0
HKD3_k127_6119367_5 ZPR1-related zinc finger protein K06874 - - 0.0000000000000000000000000000000000000000000000000002031 194.0
HKD3_k127_6119367_6 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000000001177 128.0
HKD3_k127_6119367_7 binds to the 23S rRNA K02922 - - 0.000000000000000000000000002422 111.0
HKD3_k127_6119367_8 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000002438 66.0
HKD3_k127_6119374_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 2.67e-322 996.0
HKD3_k127_6119374_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 494.0
HKD3_k127_6119374_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 391.0
HKD3_k127_6119374_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000002955 158.0
HKD3_k127_6119374_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000000003262 150.0
HKD3_k127_6119374_5 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000001742 100.0
HKD3_k127_6119374_6 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000002466 84.0
HKD3_k127_6140296_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 490.0
HKD3_k127_6140296_1 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 288.0
HKD3_k127_6140296_2 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000000000001616 224.0
HKD3_k127_6140296_3 PFAM thioesterase superfamily K02614 - - 0.00000000000000000000000009597 111.0
HKD3_k127_6145122_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.224e-221 692.0
HKD3_k127_6145122_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 520.0
HKD3_k127_6161852_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 1.033e-320 987.0
HKD3_k127_6161852_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001353 273.0
HKD3_k127_6161852_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.00000000000000000000000000005393 116.0
HKD3_k127_6188673_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 557.0
HKD3_k127_6188673_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 336.0
HKD3_k127_6188673_2 sugar phosphatases of the HAD superfamily K01101,K02566 - 3.1.3.41 0.00000000000000000000000000000000000000005605 154.0
HKD3_k127_6188673_3 - - - - 0.00000000000000000000009428 106.0
HKD3_k127_6188673_4 Belongs to the UPF0434 family - - - 0.0000000000000000006486 87.0
HKD3_k127_6188673_5 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000004371 81.0
HKD3_k127_6206428_0 PFAM peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 331.0
HKD3_k127_6213979_0 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 524.0
HKD3_k127_6213979_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 308.0
HKD3_k127_6213979_2 Encoded by - - - 0.00000000003254 69.0
HKD3_k127_6213979_3 PFAM PP-loop domain protein - - - 0.00000009682 56.0
HKD3_k127_6235381_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 611.0
HKD3_k127_6235381_1 PFAM Radical SAM domain protein K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 571.0
HKD3_k127_6235381_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 349.0
HKD3_k127_6235381_3 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 305.0
HKD3_k127_6235381_4 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002286 280.0
HKD3_k127_6235381_5 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001891 231.0
HKD3_k127_6235381_6 - - - - 0.00000000000000000000000000000000000000000004496 163.0
HKD3_k127_6235381_7 Putative metal-binding motif - - - 0.0000000000000001907 93.0
HKD3_k127_6235381_8 guanyl-nucleotide exchange factor activity K05349,K13735,K18491,K20276 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.2.1.21 0.00000000000001667 87.0
HKD3_k127_6245166_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 543.0
HKD3_k127_6245166_1 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000000000003115 220.0
HKD3_k127_6245166_2 - - - - 0.0000000000000003463 79.0
HKD3_k127_6265937_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 454.0
HKD3_k127_6265937_1 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 410.0
HKD3_k127_6265937_2 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002961 216.0
HKD3_k127_6275916_0 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000004886 200.0
HKD3_k127_6275916_1 membrane-bound metal-dependent hydrolase - - - 0.00000000000000000000000004876 117.0
HKD3_k127_6275916_2 Acetyltransferase (GNAT) domain - - - 0.0000000000002695 73.0
HKD3_k127_6275916_3 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.00000008262 57.0
HKD3_k127_6308870_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 601.0
HKD3_k127_6308870_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 402.0
HKD3_k127_6308870_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000001524 176.0
HKD3_k127_6308870_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000002903 133.0
HKD3_k127_6316902_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 441.0
HKD3_k127_6316902_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 362.0
HKD3_k127_6316902_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000002521 220.0
HKD3_k127_6316902_3 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000004673 175.0
HKD3_k127_6353678_0 PFAM Radical SAM domain protein K06937 - - 1.366e-247 771.0
HKD3_k127_6353678_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 535.0
HKD3_k127_6353678_2 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 411.0
HKD3_k127_6353678_3 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000000000001898 215.0
HKD3_k127_6353678_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000008073 199.0
HKD3_k127_6353678_5 Uncharacterised protein family UPF0058 - - - 0.000000000000000000000000000000000000000373 152.0
HKD3_k127_6353678_6 Belongs to the UPF0235 family K09131 - - 0.0000000000003194 74.0
HKD3_k127_6377190_0 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005737 336.0
HKD3_k127_6377190_1 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000004696 161.0
HKD3_k127_6393069_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 1.127e-199 635.0
HKD3_k127_6393069_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 299.0
HKD3_k127_6393069_2 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000001953 224.0
HKD3_k127_6458408_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.512e-243 762.0
HKD3_k127_6458408_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 4.854e-216 683.0
HKD3_k127_6458408_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000001414 112.0
HKD3_k127_6459105_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 526.0
HKD3_k127_6459105_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 418.0
HKD3_k127_6459105_2 Branched-chain amino acid transport system permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 368.0
HKD3_k127_6459105_3 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 304.0
HKD3_k127_6475310_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 505.0
HKD3_k127_6475310_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.00000000000000000000000000001003 121.0
HKD3_k127_6504727_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 522.0
HKD3_k127_6504727_1 bis(5'-adenosyl)-triphosphatase activity K02503,K19710 - 2.7.7.53 0.0000000000000000000000000000000008711 136.0
HKD3_k127_6511159_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 409.0
HKD3_k127_6511159_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 321.0
HKD3_k127_6511159_2 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000001641 136.0
HKD3_k127_6511159_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.000000000000000000000000000208 123.0
HKD3_k127_6511159_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000002354 89.0
HKD3_k127_6511159_5 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000003996 81.0
HKD3_k127_6511159_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000000000008124 76.0
HKD3_k127_6511159_7 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000003446 78.0
HKD3_k127_6531921_0 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007142 505.0
HKD3_k127_6531921_1 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 295.0
HKD3_k127_6531921_2 Secreted repeat of unknown function - - - 0.0000001214 60.0
HKD3_k127_6575208_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 576.0
HKD3_k127_6575208_1 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 467.0
HKD3_k127_6575208_2 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 382.0
HKD3_k127_6575208_3 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000000000002063 234.0
HKD3_k127_6588410_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 287.0
HKD3_k127_6588410_1 Ras family K06945 - - 0.000000000000000000000000000000000000000000000000000007945 195.0
HKD3_k127_6588410_3 - - - - 0.000000000000000005593 88.0
HKD3_k127_6650803_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 7.846e-302 932.0
HKD3_k127_6650803_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 6.759e-259 805.0
HKD3_k127_6650803_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 400.0
HKD3_k127_6650803_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 288.0
HKD3_k127_6650803_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.0000009485 55.0
HKD3_k127_6650803_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0006911 42.0
HKD3_k127_6652385_0 Ig-like domain from next to BRCA1 gene - - - 0.00000000000000000000000002677 118.0
HKD3_k127_6652385_1 Belongs to the glycosyl hydrolase 18 family - - - 0.000003371 57.0
HKD3_k127_6688816_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 461.0
HKD3_k127_6688816_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 367.0
HKD3_k127_6688816_2 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000002593 192.0
HKD3_k127_6688816_3 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000001933 171.0
HKD3_k127_6688816_4 PFAM response regulator receiver - - - 0.00000000000000000000001383 102.0
HKD3_k127_6688816_5 Tetratricopeptide repeat - - - 0.000000000000001856 82.0
HKD3_k127_6688816_6 Phosphate transporter family K03306 - - 0.000008758 48.0
HKD3_k127_6715416_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 319.0
HKD3_k127_6715416_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000008799 215.0
HKD3_k127_6715416_2 - - - - 0.0000000000000000000000000000007812 123.0
HKD3_k127_6755295_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 596.0
HKD3_k127_6755295_1 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 366.0
HKD3_k127_6781015_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008292 514.0
HKD3_k127_6781015_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007774 282.0
HKD3_k127_6781015_2 TfuA-like protein - - - 0.0000000000000000000000000000000000000001151 159.0
HKD3_k127_6787183_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000003954 186.0
HKD3_k127_6787183_1 PFAM Radical SAM domain protein - - - 0.000000007407 57.0
HKD3_k127_6832163_0 alpha/beta hydrolase fold K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000002548 186.0
HKD3_k127_6832163_1 Restriction endonuclease K07448 - - 0.000000000000000000000000000000000002024 151.0
HKD3_k127_6832163_2 Glyoxalase-like domain K06996 - - 0.000000000000000000000000000000000508 134.0
HKD3_k127_6832163_3 ubiquitin protein ligase activity K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0032501,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048871,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060586,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000003369 87.0
HKD3_k127_6832163_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000001055 69.0
HKD3_k127_6836693_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 423.0
HKD3_k127_6836693_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 322.0
HKD3_k127_6836693_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 319.0
HKD3_k127_6836693_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000002814 258.0
HKD3_k127_6836693_4 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000003414 259.0
HKD3_k127_6865533_0 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 431.0
HKD3_k127_6865533_1 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000006769 180.0
HKD3_k127_6865533_2 involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000008811 122.0
HKD3_k127_6869926_0 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 526.0
HKD3_k127_6869926_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 331.0
HKD3_k127_688715_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 604.0
HKD3_k127_688715_1 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 416.0
HKD3_k127_688715_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 368.0
HKD3_k127_688715_3 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.0000000000000000000000533 98.0
HKD3_k127_688715_4 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000006984 106.0
HKD3_k127_697937_0 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 511.0
HKD3_k127_697937_1 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000002714 195.0
HKD3_k127_697937_2 peptidase M42 family protein - - - 0.000000000000000000007964 101.0
HKD3_k127_6992786_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 9.539e-198 630.0
HKD3_k127_6992786_1 COG0457 FOG TPR repeat - - - 0.0001286 52.0
HKD3_k127_7060078_0 archaeal Zn-finger protein - - - 0.000000000000000000000000000000000000000000000000000002353 196.0
HKD3_k127_7060078_1 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000000000009421 181.0
HKD3_k127_7060078_2 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000005772 108.0
HKD3_k127_7060078_3 - - - - 0.00000000000001168 78.0
HKD3_k127_7066413_0 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000000000000000000000000000002281 174.0
HKD3_k127_7066413_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000331 167.0
HKD3_k127_7066413_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000001469 126.0
HKD3_k127_7066413_3 PFAM peptidase U32 K08303 - - 0.0000000000000000000007112 97.0
HKD3_k127_7066413_4 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000008381 95.0
HKD3_k127_7105318_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 489.0
HKD3_k127_7105318_1 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 326.0
HKD3_k127_7141457_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 358.0
HKD3_k127_7141457_1 - - - - 0.0000000000000000008303 93.0
HKD3_k127_7150149_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 315.0
HKD3_k127_7150149_1 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000000004388 162.0
HKD3_k127_7150149_2 SMART Elongator protein 3 MiaB NifB K06936 - - 0.000000000000000000000000000000000000000004098 158.0
HKD3_k127_7150149_3 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000000000000000006594 131.0
HKD3_k127_7150149_4 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000001825 107.0
HKD3_k127_7249677_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 445.0
HKD3_k127_7249677_1 Nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000000000000008592 173.0
HKD3_k127_7249677_2 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000749 170.0
HKD3_k127_7249677_3 PFAM Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000009656 166.0
HKD3_k127_7249677_4 - - - - 0.00000000000000000000000000004841 118.0
HKD3_k127_7289400_0 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.446e-209 673.0
HKD3_k127_7289400_1 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 351.0
HKD3_k127_7296517_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1562.0
HKD3_k127_7296517_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 2.551e-213 664.0
HKD3_k127_7296517_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 8.585e-198 622.0
HKD3_k127_7296517_3 transcription termination protein NusA K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000002223 231.0
HKD3_k127_7296517_4 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000000000000000000000000000000006037 136.0
HKD3_k127_7297711_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 488.0
HKD3_k127_7297711_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009325 385.0
HKD3_k127_7297711_2 - - - - 0.00000002355 62.0
HKD3_k127_7303858_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002786 273.0
HKD3_k127_7303858_1 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006435 253.0
HKD3_k127_7303858_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000008253 225.0
HKD3_k127_7303858_3 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000000103 220.0
HKD3_k127_7303858_4 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000003802 186.0
HKD3_k127_7303858_5 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000001285 161.0
HKD3_k127_7337649_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 364.0
HKD3_k127_7337649_1 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000004655 267.0
HKD3_k127_7337649_2 Helix-hairpin-helix domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000006691 229.0
HKD3_k127_7337649_3 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000000000003555 146.0
HKD3_k127_7347178_0 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 422.0
HKD3_k127_7347178_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 322.0
HKD3_k127_7355083_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 603.0
HKD3_k127_7355083_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 592.0
HKD3_k127_7355083_2 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 305.0
HKD3_k127_7355083_3 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 302.0
HKD3_k127_7355083_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000001508 235.0
HKD3_k127_7355083_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000000002211 155.0
HKD3_k127_7355083_6 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000000000001961 143.0
HKD3_k127_7355083_7 PFAM PUA domain containing protein K07398 - - 0.0000000000000000000000000000004532 132.0
HKD3_k127_7361299_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 7.668e-214 673.0
HKD3_k127_7361299_1 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 484.0
HKD3_k127_7361299_10 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000003846 153.0
HKD3_k127_7361299_11 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000000000000009934 131.0
HKD3_k127_7361299_12 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000003116 111.0
HKD3_k127_7361299_13 CRS1_YhbY K07574 - - 0.0000000000000000000000111 103.0
HKD3_k127_7361299_14 structural constituent of ribosome K02924 - - 0.0000000000000000004157 87.0
HKD3_k127_7361299_15 PFAM Ribosomal LX protein K02944 - - 0.0000000000007826 70.0
HKD3_k127_7361299_16 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000008634 58.0
HKD3_k127_7361299_2 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 449.0
HKD3_k127_7361299_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 431.0
HKD3_k127_7361299_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 304.0
HKD3_k127_7361299_5 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002333 279.0
HKD3_k127_7361299_6 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002421 274.0
HKD3_k127_7361299_7 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000005041 224.0
HKD3_k127_7361299_8 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000006766 205.0
HKD3_k127_7361299_9 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000002144 154.0
HKD3_k127_7369889_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 286.0
HKD3_k127_7369889_1 Roadblock LC7 K07131 - - 0.000000000000000000000000000000000000000000000000006375 182.0
HKD3_k127_7369889_2 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000213 145.0
HKD3_k127_7380242_0 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005732 274.0
HKD3_k127_7380242_1 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000001896 220.0
HKD3_k127_7380242_2 PFAM peptidase zinc-dependent K06974 - - 0.00000000000000000000000000000000000000000000000001084 186.0
HKD3_k127_7380242_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000000001152 123.0
HKD3_k127_7380242_4 - - - - 0.000002676 58.0
HKD3_k127_7403856_0 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 346.0
HKD3_k127_7403856_1 Protein of unknown function (DUF473) K09135 - - 0.000000000000000000000000000000000000007807 153.0
HKD3_k127_7403856_2 - - - - 0.00000000000000000000000004887 110.0
HKD3_k127_7403856_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000007646 72.0
HKD3_k127_7413615_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 4.594e-316 981.0
HKD3_k127_7413615_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.169e-231 727.0
HKD3_k127_7419294_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 1.565e-219 691.0
HKD3_k127_7419294_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 2.29e-215 678.0
HKD3_k127_7419294_2 PFAM glycoside hydrolase family 39 K01176 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002768 279.0
HKD3_k127_7419294_4 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000001799 197.0
HKD3_k127_7419294_5 Ig-like domain from next to BRCA1 gene - - - 0.0000000000000000000000000000000000000000000000000004637 205.0
HKD3_k127_7421481_0 COG0110 Acetyltransferase (isoleucine patch superfamily) - - - 0.00000000000000000000000000000000000000000000000000000001294 204.0
HKD3_k127_7421481_1 WbqC-like protein family - - - 0.000000000000000000000000000000000000000000000007785 178.0
HKD3_k127_7421481_2 Polysaccharide deacetylase - - - 0.000000000000000000000000105 108.0
HKD3_k127_7431988_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 471.0
HKD3_k127_7431988_1 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 295.0
HKD3_k127_7431988_2 amino acid K16263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000236 269.0
HKD3_k127_7431988_3 - - - - 0.00000000000002491 80.0
HKD3_k127_7431988_4 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000001722 70.0
HKD3_k127_7441641_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.426e-230 722.0
HKD3_k127_7441641_1 PFAM amino acid permease-associated region K20265 - - 1.905e-230 720.0
HKD3_k127_7441641_2 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 336.0
HKD3_k127_7441641_3 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002674 250.0
HKD3_k127_7441641_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000000001474 237.0
HKD3_k127_7441641_5 binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000009489 200.0
HKD3_k127_7441641_6 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000002407 170.0
HKD3_k127_7441641_7 Orn/Lys/Arg decarboxylase, C-terminal domain K01584 - 4.1.1.19 0.000000000000000000000000000001161 121.0
HKD3_k127_7441641_8 - - - - 0.0000000000000000000000009873 109.0
HKD3_k127_7445462_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000002281 260.0
HKD3_k127_7445462_1 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000000000000000000000293 103.0
HKD3_k127_7475811_0 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001041 258.0
HKD3_k127_7475811_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000001716 96.0
HKD3_k127_7475811_2 Protein of unknown function (DUF2764) - - - 0.0000000002168 68.0
HKD3_k127_7476855_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 582.0
HKD3_k127_7476855_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 401.0
HKD3_k127_7486409_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.369e-208 653.0
HKD3_k127_7486409_1 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009506 527.0
HKD3_k127_7486409_2 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 446.0
HKD3_k127_7486409_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000018 227.0
HKD3_k127_7486409_4 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000000000000000000000006423 199.0
HKD3_k127_7486409_5 PFAM Rubredoxin-type Fe(Cys)4 protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000009166 86.0
HKD3_k127_7488707_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 568.0
HKD3_k127_7488707_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 351.0
HKD3_k127_7488707_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 346.0
HKD3_k127_7488707_3 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004764 336.0
HKD3_k127_7488707_4 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006424 243.0
HKD3_k127_7488707_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000001593 214.0
HKD3_k127_7488707_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000001142 194.0
HKD3_k127_7488707_7 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000001118 171.0
HKD3_k127_7488707_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000001438 123.0
HKD3_k127_7488707_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000002029 92.0
HKD3_k127_7490326_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.098e-310 962.0
HKD3_k127_7490326_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 3.739e-228 719.0
HKD3_k127_7490326_10 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000001958 116.0
HKD3_k127_7490326_11 PFAM PspC domain protein K03973 - - 0.0000000002719 68.0
HKD3_k127_7490326_2 PFAM amino acid permease-associated region K03294 - - 2.553e-201 638.0
HKD3_k127_7490326_3 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 526.0
HKD3_k127_7490326_4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 346.0
HKD3_k127_7490326_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 318.0
HKD3_k127_7490326_6 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006108 271.0
HKD3_k127_7490326_7 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000292 248.0
HKD3_k127_7490326_8 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000253 176.0
HKD3_k127_7490326_9 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000000000000000001169 164.0
HKD3_k127_7495499_0 PFAM ABC transporter K00400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 567.0
HKD3_k127_7495499_1 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 325.0
HKD3_k127_7495499_2 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000001517 258.0
HKD3_k127_7512267_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 486.0
HKD3_k127_7512267_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000001199 224.0
HKD3_k127_7512267_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000003364 168.0
HKD3_k127_7512267_3 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000001598 71.0
HKD3_k127_7550423_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001344 253.0
HKD3_k127_7550423_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000005641 177.0
HKD3_k127_7550423_2 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000575 166.0
HKD3_k127_7582454_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008711 249.0
HKD3_k127_7582454_1 domain protein - - - 0.00000000000000000000000000000000000000001251 157.0
HKD3_k127_7582454_2 Methyltransferase domain - - - 0.00000000000000000000002661 106.0
HKD3_k127_7582454_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00005058 54.0
HKD3_k127_7587554_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 544.0
HKD3_k127_7587554_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 372.0
HKD3_k127_7587554_2 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000002618 94.0
HKD3_k127_7609919_0 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 317.0
HKD3_k127_7609919_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 303.0
HKD3_k127_7609919_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.000000000000000000000000000000000001995 138.0
HKD3_k127_7609919_3 serine-type endopeptidase activity - - - 0.0000000000000000000000000000005316 134.0
HKD3_k127_7648712_0 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000003635 145.0
HKD3_k127_7648712_1 - - - - 0.000000000000000002553 92.0
HKD3_k127_7728418_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1185.0
HKD3_k127_7728418_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0003561 48.0
HKD3_k127_7753003_0 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000942 380.0
HKD3_k127_7813938_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 2.333e-269 839.0
HKD3_k127_7813938_1 acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 555.0
HKD3_k127_7813938_2 PFAM ABC transporter K16786 - - 0.0000000000000000000000000000000000000000000000000000000000000002899 227.0
HKD3_k127_7813938_3 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.0000000000000000000000000000000000000000000000000000000000006509 224.0
HKD3_k127_7813938_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000003362 138.0
HKD3_k127_7825130_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 612.0
HKD3_k127_7825130_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009025 377.0
HKD3_k127_7839736_0 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001419 269.0
HKD3_k127_7839736_1 - - - - 0.00000000000000000001919 102.0
HKD3_k127_7839736_2 TIGRFAM molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000002017 53.0
HKD3_k127_7844044_0 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005575 394.0
HKD3_k127_7844044_1 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008988 282.0
HKD3_k127_7844044_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000007657 206.0
HKD3_k127_7897309_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003575 271.0
HKD3_k127_7897309_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002442 242.0
HKD3_k127_7897309_2 - - - - 0.00000000000000000000000000000000000000000000000000000008506 200.0
HKD3_k127_7897309_3 - - - - 0.000000000000000000000000000000000000000000000000005826 192.0
HKD3_k127_7897309_4 Sodium Bile acid symporter family K03453 - - 0.0000000000000000000000000000000007706 147.0
HKD3_k127_7897309_5 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000209 130.0
HKD3_k127_7897309_6 small multi-drug export - - - 0.0000000000000000000000008669 119.0
HKD3_k127_791407_0 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 362.0
HKD3_k127_791407_1 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008431 333.0
HKD3_k127_791407_2 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 325.0
HKD3_k127_791407_3 PFAM ABC transporter related K09695 - - 0.00000000000000000000000000000000000000000000000000004605 190.0
HKD3_k127_791407_4 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000000001047 192.0
HKD3_k127_791407_5 CHASE4 domain - - - 0.00000000000000000000000000000000000000000000000002037 202.0
HKD3_k127_791407_6 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000000000003854 167.0
HKD3_k127_791407_7 PAS domain - - - 0.00000000000000000001872 107.0
HKD3_k127_791407_8 Helix-turn-helix domain - - - 0.0002127 46.0
HKD3_k127_8061726_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 544.0
HKD3_k127_8061726_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000001365 221.0
HKD3_k127_8122892_0 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002202 243.0
HKD3_k127_8122892_1 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000000000001075 159.0
HKD3_k127_8122892_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.000000000000000000000000000000004862 131.0
HKD3_k127_8122892_3 NADPH-dependent FMN reductase - - - 0.0000000000000000007161 87.0
HKD3_k127_8181699_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.572e-281 881.0
HKD3_k127_8181699_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000007913 76.0
HKD3_k127_8225896_0 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 374.0
HKD3_k127_8225896_1 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000009019 144.0
HKD3_k127_8225896_2 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000007794 104.0
HKD3_k127_8225896_3 membrane protein of uknown function UCP014873 - - - 0.0001162 54.0
HKD3_k127_8240901_0 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 366.0
HKD3_k127_8240901_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 364.0
HKD3_k127_8240901_2 methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 352.0
HKD3_k127_8240901_3 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.0000000000000000000000000001719 115.0
HKD3_k127_8240901_4 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000004197 79.0
HKD3_k127_8249852_0 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 357.0
HKD3_k127_8249852_1 Sugar efflux transporter for intercellular exchange K15383 - - 0.0000000000000000000193 93.0
HKD3_k127_8249852_2 Methanogenesis marker protein 8 - - - 0.000000004335 58.0
HKD3_k127_8314668_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 381.0
HKD3_k127_8314668_1 GYD domain - - - 0.0000000000000000006842 92.0
HKD3_k127_8314668_2 Fe-S-cluster oxidoreductase - - - 0.0000000000000001317 85.0
HKD3_k127_8314668_3 Flavodoxin - - - 0.0000000000001318 72.0
HKD3_k127_8394555_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 472.0
HKD3_k127_8394555_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 437.0
HKD3_k127_8394555_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006309 312.0
HKD3_k127_8397788_0 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 343.0
HKD3_k127_8397788_1 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000001629 143.0
HKD3_k127_8397788_2 - - - - 0.00000000001978 74.0
HKD3_k127_8397788_3 - - - - 0.00000001742 63.0
HKD3_k127_8397788_4 - - - - 0.000002107 52.0
HKD3_k127_8404208_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 563.0
HKD3_k127_8404208_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 552.0
HKD3_k127_8404208_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 305.0
HKD3_k127_8404208_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 304.0
HKD3_k127_8404208_4 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000001976 250.0
HKD3_k127_8404208_5 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000516 220.0
HKD3_k127_8404208_6 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000001167 138.0
HKD3_k127_8419668_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 437.0
HKD3_k127_8419668_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006071 409.0
HKD3_k127_8470791_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 554.0
HKD3_k127_8473394_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 566.0
HKD3_k127_8473394_1 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 353.0
HKD3_k127_8473394_2 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000002647 169.0
HKD3_k127_8473394_3 Protein of unknown function (DUF1015) - - - 0.000004993 55.0
HKD3_k127_8477861_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 3.361e-194 612.0
HKD3_k127_8477861_1 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000003773 222.0
HKD3_k127_8487325_0 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 288.0
HKD3_k127_8487325_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000273 121.0
HKD3_k127_8487325_2 TIR domain - - - 0.000000000001815 71.0
HKD3_k127_8494460_0 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 311.0
HKD3_k127_8494460_1 Belongs to the UPF0218 family K09735 - - 0.0000000000000000000000000000000000000000000000000002053 192.0
HKD3_k127_8494460_2 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000000000000000000004234 124.0
HKD3_k127_8494460_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000000000001442 111.0
HKD3_k127_8509378_0 PFAM TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 334.0
HKD3_k127_8509378_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000001422 140.0
HKD3_k127_8509378_2 ATP synthase subunit C K02124 - - 0.0000000000000000000007789 98.0
HKD3_k127_8509378_3 Winged helix-turn-helix - - - 0.000000000000000000001252 95.0
HKD3_k127_8509378_4 GYD domain - - - 0.000000000000000001698 89.0
HKD3_k127_8523266_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 460.0
HKD3_k127_8523266_1 tetratricopeptide repeat - - - 0.0000000000000002978 81.0
HKD3_k127_8535133_0 - - - - 0.00000000000000000000000000000000000000002006 164.0
HKD3_k127_8535133_1 to orf3 of fosmid clone 4B7mr3 - - - 0.000000000000000000000000000000000001588 147.0
HKD3_k127_8574594_0 AIR synthase related protein domain protein K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 441.0
HKD3_k127_8574594_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 366.0
HKD3_k127_8574594_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 352.0
HKD3_k127_8574594_3 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000002279 257.0
HKD3_k127_8576607_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 9.193e-241 755.0
HKD3_k127_8585440_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 447.0
HKD3_k127_8585440_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 334.0
HKD3_k127_8585440_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00000000000000000000000000000000000000000000000004171 181.0
HKD3_k127_8585440_3 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000002941 154.0
HKD3_k127_8585440_4 SpoVT / AbrB like domain - - - 0.0000000000000000000000025 105.0
HKD3_k127_8597843_0 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 358.0
HKD3_k127_8597843_1 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 287.0
HKD3_k127_8597843_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000007336 229.0
HKD3_k127_8597843_3 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000000003916 180.0
HKD3_k127_8597843_4 Zn-ribbon containing protein K07163 - - 0.000000000000000000000000000000000000000000000001683 176.0
HKD3_k127_8597843_5 PFAM CBS domain containing protein - - - 0.000000000003094 68.0
HKD3_k127_8688632_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 5.427e-240 758.0
HKD3_k127_8688632_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009277 402.0
HKD3_k127_8688632_2 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001123 288.0
HKD3_k127_8688632_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002873 249.0
HKD3_k127_8688632_4 Phosphate uptake regulator, PhoU - - - 0.0000000005694 61.0
HKD3_k127_8696284_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 1.622e-265 825.0
HKD3_k127_8696284_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000006163 168.0
HKD3_k127_8696284_2 - - - - 0.000000000000000008936 87.0
HKD3_k127_8700246_0 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000006105 114.0
HKD3_k127_8700246_1 sh3 domain protein - - - 0.0000000004044 72.0
HKD3_k127_8700246_2 M1 (1,4-beta-N-acetylmuramidase) K07273 - - 0.0000003634 62.0
HKD3_k127_8700246_3 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD - - - 0.0008485 51.0
HKD3_k127_8701601_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007774 462.0
HKD3_k127_8701601_1 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 289.0
HKD3_k127_8701601_2 - - - - 0.0000000000000000000000000414 113.0
HKD3_k127_8701601_3 - - - - 0.00000006147 61.0
HKD3_k127_8714355_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000004699 232.0
HKD3_k127_8714355_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000006765 202.0
HKD3_k127_8719821_0 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 354.0
HKD3_k127_8719821_1 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 304.0
HKD3_k127_8719821_2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.00000000000000000000000000000000004078 135.0
HKD3_k127_8719821_3 PDGLE domain K02009 - - 0.0000000000000000000007301 103.0
HKD3_k127_8720988_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 342.0
HKD3_k127_8720988_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009254 273.0
HKD3_k127_8720988_2 DNA polymerase beta - - - 0.000000000000000000000000000000000000000831 155.0
HKD3_k127_8720988_3 HEPN domain K09132 - - 0.0008386 48.0
HKD3_k127_8731651_0 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 526.0
HKD3_k127_8731651_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000004227 221.0
HKD3_k127_8731651_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000008221 93.0
HKD3_k127_8731651_3 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00009016 44.0
HKD3_k127_8742407_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001124 266.0
HKD3_k127_8742407_1 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004107 265.0
HKD3_k127_8773248_0 TIGRFAM cell division ATPase MinD K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 377.0
HKD3_k127_8773248_1 - - - - 0.0000000000000000000000000000000000000000000007148 173.0
HKD3_k127_8773248_2 PFAM type II secretion system protein E K07332 - - 0.00000000000000000000000000001274 136.0
HKD3_k127_8773248_3 - - - - 0.00002583 53.0
HKD3_k127_8786742_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 1.218e-265 827.0
HKD3_k127_8786742_1 ArsR transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000002477 227.0
HKD3_k127_8786742_2 SMART regulatory protein, Crp K07730 - - 0.00000000000003847 73.0
HKD3_k127_87906_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 3.064e-258 813.0
HKD3_k127_87906_1 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 336.0
HKD3_k127_87906_2 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 289.0
HKD3_k127_87906_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000003412 157.0
HKD3_k127_8833299_0 - - - - 0.000000000000000000000000000000005448 136.0
HKD3_k127_8833299_1 Winged helix-turn-helix - - - 0.000000000000000000000000000000006684 138.0
HKD3_k127_8833299_2 ATP synthase subunit C K02124 - - 0.0000000000000000000002008 99.0
HKD3_k127_8833299_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000002584 90.0
HKD3_k127_8869187_0 Heat shock 70 kDa protein K04043 - - 1.557e-297 924.0
HKD3_k127_8869187_1 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000007272 229.0
HKD3_k127_8869187_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000004995 214.0
HKD3_k127_8869187_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000001506 145.0
HKD3_k127_8876440_0 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 339.0
HKD3_k127_8876440_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001198 269.0
HKD3_k127_8876440_2 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000002758 239.0
HKD3_k127_8876440_3 - - - - 0.000000000000000000000000000000000000000000542 168.0
HKD3_k127_8876440_5 PFAM Yip1 domain - - - 0.00000000000000000000000001244 121.0
HKD3_k127_8876440_6 response to heat K03668,K09914 - - 0.000000000000002414 86.0
HKD3_k127_8876440_7 VIT family - - - 0.000000009136 66.0
HKD3_k127_8876440_8 Ion channel K10716 - - 0.0000003872 55.0
HKD3_k127_8876440_9 - - - - 0.0003575 48.0
HKD3_k127_8927762_0 V-type ATPase 116kDa subunit family K02123 - - 7.957e-216 689.0
HKD3_k127_8927762_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000001085 117.0
HKD3_k127_8927762_2 ATP synthase subunit C K02124 - - 0.0000000000000000000001918 98.0
HKD3_k127_8927762_3 H subunit K02107 - - 0.0001938 48.0
HKD3_k127_8932706_0 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 436.0
HKD3_k127_8932706_1 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 418.0
HKD3_k127_8932706_2 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 333.0
HKD3_k127_8946312_0 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 599.0
HKD3_k127_8946312_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 481.0
HKD3_k127_8946312_2 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000004121 113.0
HKD3_k127_8975008_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 8.036e-292 905.0
HKD3_k127_8975008_1 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000005815 203.0
HKD3_k127_8975008_2 - - - - 0.00000000000000000000000000000000000000006705 154.0
HKD3_k127_8975008_3 - - - - 0.000000000000000000000000000003275 124.0
HKD3_k127_8993089_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 541.0
HKD3_k127_8993089_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002588 272.0
HKD3_k127_8993089_2 - - - - 0.0001746 44.0
HKD3_k127_9011567_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000004533 238.0
HKD3_k127_9011567_1 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000001839 228.0
HKD3_k127_9011567_2 - - - - 0.00000000000000000000000000000008277 130.0
HKD3_k127_9011567_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000002815 55.0
HKD3_k127_9108880_0 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008703 298.0
HKD3_k127_9108880_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003226 286.0
HKD3_k127_9108880_2 PFAM PEGA domain - - - 0.00000000000000000000000000000000000000000000000000000000393 207.0
HKD3_k127_9149344_0 PFAM PilT protein domain protein K06865 - - 2.749e-273 855.0
HKD3_k127_9149344_1 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 514.0
HKD3_k127_9149344_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 332.0
HKD3_k127_9149344_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 285.0
HKD3_k127_9149344_4 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001006 276.0
HKD3_k127_9149344_5 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000009131 184.0
HKD3_k127_9149344_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000007116 147.0
HKD3_k127_9149344_7 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000001501 143.0
HKD3_k127_91892_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 529.0
HKD3_k127_91892_1 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 502.0
HKD3_k127_91892_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003443 285.0
HKD3_k127_91892_3 Flavodoxin - - - 0.0000000000000000000000000000000000005004 147.0
HKD3_k127_9211478_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 595.0
HKD3_k127_9211478_1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 315.0
HKD3_k127_9211478_2 N-6 DNA Methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 331.0
HKD3_k127_9211478_3 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 292.0
HKD3_k127_9211478_4 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000002065 234.0
HKD3_k127_9211478_5 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000003468 209.0
HKD3_k127_9211478_6 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000009226 166.0
HKD3_k127_9211478_7 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000004888 154.0