Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
protein related to deoxyribodipyrimidine photolyase
K06876
-
-
1.435e-303
937.0
HSJS1_k127_1131463_4
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
K03308
-
-
1.256e-295
912.0
HSJS1_k127_1131463_5
COG0415 Deoxyribodipyrimidine photolyase
K01669
-
4.1.99.3
1.272e-288
890.0
HSJS1_k127_1131463_6
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
4.087e-243
751.0
HSJS1_k127_1131463_7
Belongs to the DNA photolyase family
K01669
-
4.1.99.3
4.882e-217
682.0
HSJS1_k127_1131463_8
Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
K03705
-
-
5.95e-213
665.0
HSJS1_k127_1131463_9
hydroxymethylglutaryl-CoA reductase
K00021
-
1.1.1.34
2.045e-199
637.0
HSJS1_k127_1132972_0
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K01012
-
2.8.1.6
2.359e-246
761.0
HSJS1_k127_1132972_4
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
6.601e-227
703.0
HSJS1_k127_1132972_5
Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K01735
-
4.2.3.4
3.406e-218
679.0
HSJS1_k127_1132972_6
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
7.754e-293
900.0
HSJS1_k127_113844_1
Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K01775
-
5.1.1.1
1.274e-197
619.0
HSJS1_k127_113844_2
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
K21071
-
2.7.1.11,2.7.1.90
4.782e-267
823.0
HSJS1_k127_1138528_3
Periplasmic binding protein domain
K01999,K11959
-
-
2.459e-258
797.0
HSJS1_k127_1138528_4
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates
K01426
-
3.5.1.4
1.621e-240
742.0
HSJS1_k127_1138528_5
Belongs to the binding-protein-dependent transport system permease family
K11961
-
-
2.11e-238
738.0
HSJS1_k127_1138528_6
COG0542 ATPases with chaperone activity, ATP-binding subunit
-
-
-
2.315e-206
644.0
HSJS1_k127_1138528_7
Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
K02558
-
6.3.2.45
1.485e-196
615.0
HSJS1_k127_1138528_8
Belongs to the binding-protein-dependent transport system permease family
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
-
-
-
0.0000000000004024
69.0
HSJS1_k127_1143920_9
PKHD-type hydroxylase
K07336
-
-
0.0001847
45.0
HSJS1_k127_1147548_0
Large extracellular alpha-helical protein
K06894
-
-
0.0
3311.0
HSJS1_k127_1147548_1
Glycoside-hydrolase family GH114
K21006
-
-
0.0
1622.0
HSJS1_k127_1147548_10
COG3639 ABC-type phosphate phosphonate transport system, permease component
K02042
-
-
2.697e-290
896.0
HSJS1_k127_1147548_11
membrane
K21012
-
-
2.081e-249
775.0
HSJS1_k127_1147548_12
PelD GGDEF domain
K21009
-
-
4.431e-249
773.0
HSJS1_k127_1147548_13
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
-
-
-
2.547e-232
725.0
HSJS1_k127_1147548_14
fatty acid desaturase
-
-
-
5.927e-231
717.0
HSJS1_k127_1147548_15
-
-
-
-
2.47e-224
707.0
HSJS1_k127_1147548_16
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
Belongs to the selenophosphate synthase 1 family. Class I subfamily
K01008
-
2.7.9.3
0.0
1158.0
HSJS1_k127_1147548_41
Tetratricopeptide repeat
K21010
-
-
0.00000000000000000000000000000000000000000007248
173.0
HSJS1_k127_1147548_42
-
-
-
-
0.00000000000000000000000000000000000000000009282
167.0
HSJS1_k127_1147548_43
Dodecin
K09165
-
-
0.000000000000000000000000000000000002243
140.0
HSJS1_k127_1147548_44
Tetratricopeptide repeat
K21007
-
-
0.0000000001845
72.0
HSJS1_k127_1147548_5
Belongs to the GMC oxidoreductase family
-
-
-
0.0
1077.0
HSJS1_k127_1147548_6
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
K05592
-
3.6.4.13
0.0
1030.0
HSJS1_k127_1147548_7
Pkd domain containing protein
-
-
-
0.0
1024.0
HSJS1_k127_1147548_8
Glycosyl Transferase
K20921,K21011
-
-
1.796e-300
925.0
HSJS1_k127_1147548_9
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
K01768
-
4.6.1.1
5.186e-293
904.0
HSJS1_k127_1165171_0
Esterase of the alpha-beta hydrolase superfamily
-
-
-
1.029e-208
653.0
HSJS1_k127_1165171_1
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
2.415e-268
828.0
HSJS1_k127_1175127_4
alpha beta
-
-
-
2.728e-253
783.0
HSJS1_k127_1175127_5
Belongs to the ALAD family
K01698
-
4.2.1.24
1.372e-209
653.0
HSJS1_k127_1175127_6
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
-
-
-
3.92e-198
627.0
HSJS1_k127_1241396_20
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
Belongs to the heme-copper respiratory oxidase family
K02298
-
1.10.3.10
0.0
1342.0
HSJS1_k127_1265819_1
Histidine kinase
K15011
-
2.7.13.3
1.474e-273
844.0
HSJS1_k127_1265819_2
COG0477 Permeases of the major facilitator superfamily
-
-
-
1.859e-257
797.0
HSJS1_k127_1265819_3
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1523.0
HSJS1_k127_1374462_10
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
With YejAEF is involved in resistance to microcin C
K13894
-
-
3.351e-212
661.0
HSJS1_k127_1374462_13
ABC transporter permease
K13895
-
-
2.229e-205
642.0
HSJS1_k127_1374462_14
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COG4166 ABC-type oligopeptide transport system, periplasmic component
K13893
-
-
0.0
1137.0
HSJS1_k127_1374462_20
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
K01886
-
6.1.1.18
0.0
1135.0
HSJS1_k127_1374462_30
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K00573
-
2.1.1.77
0.0000000000000000000000000000000004143
130.0
HSJS1_k127_1374462_35
-
-
-
-
0.00000000000000002155
84.0
HSJS1_k127_1374462_36
-
-
-
-
0.000000000018
65.0
HSJS1_k127_1374462_4
ABC-type oligopeptide transport system, periplasmic component
K13893
-
-
0.0
1072.0
HSJS1_k127_1374462_5
choline dehydrogenase activity
-
-
-
0.0
1025.0
HSJS1_k127_1374462_6
peptidylprolyl isomerase
K03770
-
5.2.1.8
8.422e-315
974.0
HSJS1_k127_1374462_7
COG2303 Choline dehydrogenase and related flavoproteins
-
-
-
7.81e-294
906.0
HSJS1_k127_1374462_8
Belongs to the ABC transporter superfamily
K13896
-
-
1.375e-271
842.0
HSJS1_k127_1374462_9
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
5e-324
993.0
HSJS1_k127_1392409_1
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
2.616e-297
912.0
HSJS1_k127_1392409_2
COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K03185
-
-
1.632e-230
717.0
HSJS1_k127_1392409_3
Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes
-
-
-
0.0
1322.0
HSJS1_k127_1460911_10
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.000000000000000000006363
91.0
HSJS1_k127_1460911_4
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
2.401e-298
919.0
HSJS1_k127_1460911_5
unusual protein kinase
-
-
-
4.695e-261
807.0
HSJS1_k127_1460911_6
Major facilitator superfamily
-
-
-
3.297e-245
764.0
HSJS1_k127_1460911_7
COG3552 Protein containing von Willebrand factor type A (vWA) domain
K07161
-
-
1.985e-239
745.0
HSJS1_k127_1460911_8
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
1.542e-238
741.0
HSJS1_k127_1460911_9
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
1.024e-226
704.0
HSJS1_k127_1475607_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18303
-
-
0.0
1835.0
HSJS1_k127_1475607_1
ABC transporter ATP-binding protein
K06158
-
-
0.0
1174.0
HSJS1_k127_1475607_10
protein conserved in bacteria
-
-
-
0.00000000000000000000000000000000007102
133.0
HSJS1_k127_1475607_11
nuclear chromosome segregation
-
-
-
0.0005538
45.0
HSJS1_k127_1475607_2
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
K00833
-
2.6.1.62
1.321e-253
789.0
HSJS1_k127_1475607_3
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
2.879e-232
722.0
HSJS1_k127_1517934_7
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
1.023e-230
716.0
HSJS1_k127_1517934_8
-
-
-
-
6.939e-229
710.0
HSJS1_k127_1517934_9
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Part of a membrane complex involved in electron transport
K03614
-
-
4.081e-212
662.0
HSJS1_k127_1605506_19
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
K01207
-
3.2.1.52
1.559e-201
630.0
HSJS1_k127_1605506_2
Part of a membrane complex involved in electron transport
K03615
-
-
0.0
1581.0
HSJS1_k127_1605506_20
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1300.0
HSJS1_k127_1605506_40
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
K01869
-
6.1.1.4
0.0
1599.0
HSJS1_k127_1684116_1
Catalyzes cross-linking of the peptidoglycan cell wall
K05515
-
3.4.16.4
0.0
1185.0
HSJS1_k127_1684116_10
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Transfers the fatty acyl group on membrane lipoproteins
K03820
-
-
6.67e-282
871.0
HSJS1_k127_1684116_5
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
2.334e-267
827.0
HSJS1_k127_1684116_6
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
3.541e-257
795.0
HSJS1_k127_1684116_7
NAD(FAD)-dependent dehydrogenases
K17218
-
1.8.5.4
8.146e-244
756.0
HSJS1_k127_1684116_8
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
3.623e-235
730.0
HSJS1_k127_1684116_9
Peptidoglycan polymerase that is essential for cell wall elongation
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0
1007.0
HSJS1_k127_1699640_10
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
7.89e-287
884.0
HSJS1_k127_1699640_3
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
9.499e-253
784.0
HSJS1_k127_1699640_5
-
-
-
-
4.403e-228
724.0
HSJS1_k127_1699640_6
-
-
-
-
2.101e-199
629.0
HSJS1_k127_1699640_7
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
6.711e-196
615.0
HSJS1_k127_1699640_8
Belongs to the glucose-6-phosphate 1-epimerase family
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
K03578
-
3.6.4.13
0.0
1096.0
HSJS1_k127_1703249_1
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
K00648,K16872
-
2.3.1.180,2.3.1.207
8.189e-231
717.0
HSJS1_k127_1703249_5
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
K05539
-
-
3.726e-203
635.0
HSJS1_k127_1703249_6
Gluconolactonase
-
-
-
3.434e-202
633.0
HSJS1_k127_1703249_7
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
5.552e-251
777.0
HSJS1_k127_1706901_2
Belongs to the acetylglutamate kinase family. ArgB subfamily
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase
K03568
-
-
4.055e-295
907.0
HSJS1_k127_1706974_2
Involved in formation and maintenance of cell shape
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
K14267
-
2.6.1.17
9.784e-255
786.0
HSJS1_k127_1726626_4
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
8.641e-238
740.0
HSJS1_k127_1726626_5
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
4.436e-224
700.0
HSJS1_k127_1726626_6
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
4.082e-222
692.0
HSJS1_k127_1726626_7
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
9.961e-215
671.0
HSJS1_k127_1726626_8
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
K01962
-
2.1.3.15,6.4.1.2
4.27e-202
630.0
HSJS1_k127_1726626_9
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K02536
-
2.3.1.191
3.236e-198
620.0
HSJS1_k127_1728784_0
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2204.0
HSJS1_k127_1728784_1
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
-
-
-
0.0
1019.0
HSJS1_k127_1836315_5
Nitrate nitrite transporter
K02575
-
-
2.634e-304
936.0
HSJS1_k127_1836315_6
Trypsin-like serine protease
-
-
-
2.986e-291
899.0
HSJS1_k127_1836315_7
reductase
K00362
-
1.7.1.15
1.373e-250
776.0
HSJS1_k127_1836315_8
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Beta-lactamase class C and other penicillin binding
-
-
-
6.703e-256
792.0
HSJS1_k127_1868497_6
acyl-CoA transferases carnitine dehydratase
K07749
-
2.8.3.16
6.379e-254
784.0
HSJS1_k127_1868497_7
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
1.113e-248
770.0
HSJS1_k127_1927113_1
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
4.185e-205
641.0
HSJS1_k127_1927113_10
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000000000003068
126.0
HSJS1_k127_1927113_11
DNA polymerase III subunit delta
K02341
-
2.7.7.7
0.00000000000000000000006478
101.0
HSJS1_k127_1927113_2
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1862.0
HSJS1_k127_1997277_1
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1474.0
HSJS1_k127_202993_10
Belongs to the cysteine synthase cystathionine beta- synthase family
Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K13776
-
-
0.0
1210.0
HSJS1_k127_202993_3
Acetyl propionyl-CoA carboxylase, alpha subunit
K13777
-
6.4.1.5
0.0
1136.0
HSJS1_k127_202993_4
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA
K03215
-
2.1.1.190
7.568e-300
919.0
HSJS1_k127_202993_5
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.151e-266
823.0
HSJS1_k127_202993_6
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
-
-
-
1.646e-263
813.0
HSJS1_k127_202993_7
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
9.716e-256
792.0
HSJS1_k127_202993_8
acyl-CoA dehydrogenase
K11731
-
-
3.258e-248
766.0
HSJS1_k127_202993_9
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K06917
-
-
1.242e-203
640.0
HSJS1_k127_2145584_0
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
1.818e-310
953.0
HSJS1_k127_2145584_1
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01825
-
1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8
0.0
1408.0
HSJS1_k127_2157038_10
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
4.295e-196
617.0
HSJS1_k127_2157038_11
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.00000000000000000000000000000000000000000007026
160.0
HSJS1_k127_2253987_28
there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
K02913
-
-
0.0000000000000000000000000004305
113.0
HSJS1_k127_2253987_3
COG1398 Fatty-acid desaturase
-
-
-
1.283e-254
787.0
HSJS1_k127_2253987_4
Major facilitator superfamily
-
-
-
9.097e-245
759.0
HSJS1_k127_2253987_5
COG4963 Flp pilus assembly protein, ATPase CpaE
-
-
-
1.553e-236
734.0
HSJS1_k127_2253987_6
COG4962 Flp pilus assembly protein, ATPase CpaF
K02283
-
-
7.44e-236
731.0
HSJS1_k127_2253987_7
Belongs to the GSP D family
K02280
-
-
5.495e-224
702.0
HSJS1_k127_2253987_8
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
1.072e-208
652.0
HSJS1_k127_2253987_9
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Domain of unknown function (DUF5122) beta-propeller
-
-
-
0.000000000000000003472
91.0
HSJS1_k127_2279224_0
-
-
-
-
0.0
1448.0
HSJS1_k127_2279224_1
Bacterial periplasmic substrate-binding proteins
-
-
-
0.0
1184.0
HSJS1_k127_2279224_2
Belongs to the beta-ketoacyl-ACP synthases family
K18473
-
2.3.1.180
0.0
1103.0
HSJS1_k127_2279224_3
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
1.354e-242
751.0
HSJS1_k127_2279224_4
PLD-like domain
-
-
-
7.44e-214
672.0
HSJS1_k127_2279224_5
Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0
1568.0
HSJS1_k127_2316245_1
Calcineurin-like phosphoesterase
K14379
-
3.1.3.2
0.0
1224.0
HSJS1_k127_2316245_10
COG3243 Poly(3-hydroxyalkanoate) synthetase
K03821
-
-
1.229e-233
726.0
HSJS1_k127_2316245_11
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K02502
-
-
7.498e-228
710.0
HSJS1_k127_2316245_12
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
6.682e-219
681.0
HSJS1_k127_2316245_13
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
K06949
-
3.1.3.100
1.24e-198
624.0
HSJS1_k127_2316245_14
HflC and HflK could encode or regulate a protease
K04088
-
-
3.162e-195
617.0
HSJS1_k127_2316245_15
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Uncharacterized protein conserved in bacteria (DUF2065)
K09937
-
-
0.00000000000000000000000007349
109.0
HSJS1_k127_2316245_3
Phosphodiesterase alkaline phosphatase D
K01113
-
3.1.3.1
3.378e-317
977.0
HSJS1_k127_2316245_4
Belongs to the alkaline phosphatase family
K01077
-
3.1.3.1
4.008e-307
947.0
HSJS1_k127_2316245_5
Belongs to the alkaline phosphatase family
K01077
-
3.1.3.1
8.462e-303
932.0
HSJS1_k127_2316245_6
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
4.075e-286
887.0
HSJS1_k127_2316245_7
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
8.931e-279
859.0
HSJS1_k127_2316245_8
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
1.202e-273
845.0
HSJS1_k127_2316245_9
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
4.299e-250
784.0
HSJS1_k127_2318649_0
Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
Belongs to the acetylglutamate kinase family. ArgB subfamily
K00930,K22478
-
2.3.1.1,2.7.2.8
0.000000000000001054
76.0
HSJS1_k127_2360863_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1460.0
HSJS1_k127_2459455_10
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.0
1177.0
HSJS1_k127_2459455_20
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1274.0
HSJS1_k127_2484588_1
Chemotaxis sensory transducer family protein
-
-
-
3.802e-319
979.0
HSJS1_k127_2484588_2
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
1.468e-303
934.0
HSJS1_k127_2484588_3
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
0.0
1502.0
HSJS1_k127_2484683_10
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1345.0
HSJS1_k127_2484683_20
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K02956
-
-
0.0000000000000000001109
88.0
HSJS1_k127_2484683_34
MFS transporter
-
-
-
0.00000000000002752
74.0
HSJS1_k127_2484683_4
COG0038 Chloride channel protein EriC
-
-
-
5.759e-287
884.0
HSJS1_k127_2484683_5
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
2.182e-285
879.0
HSJS1_k127_2484683_6
regulator
-
-
-
1.982e-267
825.0
HSJS1_k127_2484683_7
Glutamate-1-semialdehyde aminotransferase
K01845
-
5.4.3.8
2.466e-265
820.0
HSJS1_k127_2484683_8
Aminotransferase
-
-
-
3.404e-230
717.0
HSJS1_k127_2484683_9
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K00145
-
1.2.1.38
2.214e-225
699.0
HSJS1_k127_2537509_0
type II secretion system protein
K02454
-
-
0.0
1163.0
HSJS1_k127_2537509_1
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
5.027e-277
853.0
HSJS1_k127_2537509_2
Belongs to the acetyltransferase family. ArgA subfamily
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
K00974
-
2.7.7.72
2.305e-255
792.0
HSJS1_k127_254617_5
phosphotransferase related to Ser Thr protein
K07102
-
2.7.1.221
6.942e-218
676.0
HSJS1_k127_254617_6
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K03771
-
5.2.1.8
1.588e-216
679.0
HSJS1_k127_254617_7
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
2.911e-303
934.0
HSJS1_k127_2655710_4
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
6.063e-301
924.0
HSJS1_k127_2655710_5
histidyl-tRNA synthetase
K01892
-
6.1.1.21
6.305e-244
754.0
HSJS1_k127_2655710_6
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1611.0
HSJS1_k127_2715324_1
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01950
-
6.3.5.1
0.0
1062.0
HSJS1_k127_2715324_2
COG0642 Signal transduction histidine kinase
K02668
-
2.7.13.3
1.512e-290
898.0
HSJS1_k127_2715324_3
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
2.161e-201
631.0
HSJS1_k127_2715324_4
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
-
-
-
0.0
1300.0
HSJS1_k127_2786688_1
receptor
K02014
-
-
0.0
1209.0
HSJS1_k127_2786688_2
ABC transporter ATP-binding protein
-
-
-
0.0
1094.0
HSJS1_k127_2786688_3
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
3.006e-273
841.0
HSJS1_k127_2786688_4
( 3 oxidation state) methyltransferase
K07755
-
2.1.1.137
3.128e-218
680.0
HSJS1_k127_2786688_5
PepSY-associated TM helix
-
-
-
1.622e-199
625.0
HSJS1_k127_2786688_6
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.00000000000000000000000000001202
118.0
HSJS1_k127_2804814_0
2-oxoglutarate dehydrogenase
K00164
-
1.2.4.2
0.0
1879.0
HSJS1_k127_2804814_1
Tfp pilus assembly protein
K08086
-
-
0.0
1349.0
HSJS1_k127_2804814_10
Belongs to the citrate synthase family
K01647
-
2.3.3.1
1.387e-255
792.0
HSJS1_k127_2804814_11
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
5.077e-249
770.0
HSJS1_k127_2804814_12
Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
-
-
-
2.008e-245
765.0
HSJS1_k127_2804814_13
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
5.636e-244
756.0
HSJS1_k127_2804814_14
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
3.355e-238
738.0
HSJS1_k127_2804814_15
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
5.256e-233
722.0
HSJS1_k127_2804814_16
COG0515 Serine threonine protein kinase
-
-
-
6.814e-227
707.0
HSJS1_k127_2804814_17
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
2.259e-221
687.0
HSJS1_k127_2804814_18
Belongs to the folylpolyglutamate synthase family
K11754
-
6.3.2.12,6.3.2.17
3.791e-212
664.0
HSJS1_k127_2804814_19
COG0477 Permeases of the major facilitator superfamily
K05820
-
-
2.619e-211
661.0
HSJS1_k127_2804814_2
Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily
K00239
-
1.3.5.1,1.3.5.4
0.0
1199.0
HSJS1_k127_2804814_20
Glycerol-3-phosphate dehydrogenase
K00057
-
1.1.1.94
3.103e-205
640.0
HSJS1_k127_2804814_21
Preprotein translocase subunit SecA
-
-
-
5.422e-194
608.0
HSJS1_k127_2804814_22
COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
COG1585 Membrane protein implicated in regulation of membrane protease activity
K07340
-
-
0.000000000000000000000001069
103.0
HSJS1_k127_2808733_0
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
0.0
1049.0
HSJS1_k127_2864214_1
An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
K01961
-
6.3.4.14,6.4.1.2
8.939e-290
891.0
HSJS1_k127_2864214_10
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
K03578
-
3.6.4.13
0.0
1365.0
HSJS1_k127_2889155_1
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
8.353e-308
945.0
HSJS1_k127_2928550_1
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
1.518e-295
909.0
HSJS1_k127_2928550_2
Rod shape-determining protein
K03569
-
-
7.465e-229
709.0
HSJS1_k127_2928550_3
Belongs to the enoyl-CoA hydratase isomerase family
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Involved in formation and maintenance of cell shape
K03570
-
-
0.00000000000000000000000000006273
116.0
HSJS1_k127_2932158_0
Pfam:DUF1446
-
-
-
0.0
1092.0
HSJS1_k127_2932158_1
Acetyl-CoA carboxylase
K13778
-
6.4.1.5
0.0
1022.0
HSJS1_k127_2932158_11
COG1073 Hydrolases of the alpha beta superfamily
-
-
-
0.00000008438
53.0
HSJS1_k127_2932158_2
Transposase
-
-
-
2.331e-270
837.0
HSJS1_k127_2932158_3
COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
-
-
-
4.403e-225
698.0
HSJS1_k127_2932158_4
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K03147
-
4.1.99.17
0.0
1269.0
HSJS1_k127_2993107_10
Belongs to the binding-protein-dependent transport system permease family
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1246.0
HSJS1_k127_2993107_20
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
-
-
-
0.0000000000000000000000001616
113.0
HSJS1_k127_3097187_7
Protein of unknown function (DUF2815)
-
-
-
0.00000000000146
76.0
HSJS1_k127_3097187_9
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0002197
47.0
HSJS1_k127_3110432_0
COG0591 Na proline symporter
-
-
-
0.0
2119.0
HSJS1_k127_3110432_1
COG2909 ATP-dependent transcriptional regulator
-
-
-
0.0
1508.0
HSJS1_k127_3110432_10
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
4.97e-227
705.0
HSJS1_k127_3110432_11
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K11752
-
1.1.1.193,3.5.4.26
1.01e-225
701.0
HSJS1_k127_3110432_12
Converts GTP to 7,8-dihydroneopterin triphosphate
K09007
-
3.5.4.16
2.893e-206
644.0
HSJS1_k127_3110432_13
Gram-negative porin
-
-
-
1.375e-202
633.0
HSJS1_k127_3110432_14
Bacterial extracellular solute-binding protein, family 7
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1172.0
HSJS1_k127_3110432_30
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.00000000000000000000000000000004806
127.0
HSJS1_k127_3110432_37
-
-
-
-
0.0000000000000000000000000000004147
124.0
HSJS1_k127_3110432_4
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1112.0
HSJS1_k127_3110432_5
Animal haem peroxidase
-
-
-
1.294e-302
928.0
HSJS1_k127_3110432_6
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00836
-
2.6.1.76
7.917e-280
866.0
HSJS1_k127_3110432_7
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
1.481e-255
790.0
HSJS1_k127_3110432_8
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.095e-248
769.0
HSJS1_k127_3110432_9
GGDEF domain
-
-
-
5.164e-232
722.0
HSJS1_k127_3133142_0
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
2550.0
HSJS1_k127_3133142_1
repeat protein
-
-
-
0.0
1020.0
HSJS1_k127_3133142_10
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
6.688e-211
657.0
HSJS1_k127_3133142_11
Permease
K03548
-
-
1.806e-195
614.0
HSJS1_k127_3133142_12
Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
3.572e-264
818.0
HSJS1_k127_3133142_8
repeat protein
-
-
-
8.817e-258
797.0
HSJS1_k127_3133142_9
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
6.187e-242
749.0
HSJS1_k127_3361906_3
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
-
-
-
6.05e-224
708.0
HSJS1_k127_336331_10
Bacterial transferase hexapeptide (six repeats)
K00638,K18234
-
2.3.1.28
0.0000000000000000000000000000545
125.0
HSJS1_k127_336331_12
Major facilitator superfamily
-
-
-
0.000000001593
59.0
HSJS1_k127_336331_2
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
COG2104 Sulfur transfer protein involved in thiamine biosynthesis
K03154
-
-
0.000000000000000000000000000003537
122.0
HSJS1_k127_3382622_0
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
K01007
-
2.7.9.2
2.599e-316
972.0
HSJS1_k127_3382622_1
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
0.0
1152.0
HSJS1_k127_3389007_1
COG0457 FOG TPR repeat
-
-
-
3.437e-305
942.0
HSJS1_k127_3389007_10
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
3.446e-222
690.0
HSJS1_k127_3389007_11
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K07568
-
2.4.99.17
5.111e-215
669.0
HSJS1_k127_3389007_12
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K00948
-
2.7.6.1
2.567e-200
625.0
HSJS1_k127_3389007_13
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K02433
-
6.3.5.6,6.3.5.7
4.306e-296
910.0
HSJS1_k127_3389007_4
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00823
-
2.6.1.19
1.052e-268
828.0
HSJS1_k127_3389007_5
aminotransferase
K09459,K10907
-
4.1.1.82
1.796e-262
810.0
HSJS1_k127_3389007_6
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
4.178e-255
789.0
HSJS1_k127_3389007_7
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
1.336e-247
765.0
HSJS1_k127_3389007_8
Tartrate dehydrogenase
K07246
-
1.1.1.83,1.1.1.93,4.1.1.73
1.29e-226
704.0
HSJS1_k127_3389007_9
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
0.0
1062.0
HSJS1_k127_3399863_3
NADH dehydrogenase
K03885
-
1.6.99.3
3.003e-274
845.0
HSJS1_k127_3399863_4
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00210,K00800
-
1.3.1.12,2.5.1.19
0.0
1328.0
HSJS1_k127_3401149_1
thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
K02945
-
-
0.0
1085.0
HSJS1_k127_3401149_2
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K19804
-
-
1.145e-239
745.0
HSJS1_k127_3401149_3
Belongs to the cytidylate kinase family. Type 1 subfamily
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K02950
-
-
0.0000000000000000000108
91.0
HSJS1_k127_3403424_9
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000000001526
81.0
HSJS1_k127_3406023_0
ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
K02004
-
-
0.0
1212.0
HSJS1_k127_3406023_1
Domain of Unknown Function (DUF349)
-
-
-
0.0
1206.0
HSJS1_k127_3406023_10
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K00383
-
1.8.1.7
4.154e-251
779.0
HSJS1_k127_3406023_11
P-aminobenzoate N-oxygenase AurF
-
-
-
2.395e-234
725.0
HSJS1_k127_3406023_12
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
-
-
-
0.0
1140.0
HSJS1_k127_3406023_20
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
9.721e-218
679.0
HSJS1_k127_3433152_5
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
COG2931 RTX toxins and related Ca2 -binding proteins
-
-
-
0.0003269
51.0
HSJS1_k127_3442900_0
highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues
K01915
-
6.3.1.2
1.612e-287
885.0
HSJS1_k127_3448677_0
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1336.0
HSJS1_k127_3448677_1
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
4.096e-241
746.0
HSJS1_k127_3448677_2
catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
K01624
-
4.1.2.13
6.93e-231
715.0
HSJS1_k127_3448677_3
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134,K03472
-
1.2.1.12,1.2.1.72
1.316e-210
656.0
HSJS1_k127_3448677_4
COG2267 Lysophospholipase
K01048
-
3.1.1.5
1.6e-198
619.0
HSJS1_k127_3448677_5
Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Required for chromosome condensation and partitioning
K03529
-
-
0.0
2112.0
HSJS1_k127_3456433_1
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1289.0
HSJS1_k127_3456433_3
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K15461
-
2.1.1.61
0.0
1076.0
HSJS1_k127_3456433_4
Aminotransferase
K00812
-
2.6.1.1
9.905e-248
769.0
HSJS1_k127_3456433_5
COG2148 Sugar transferases involved in lipopolysaccharide synthesis
K03606,K21303
-
2.7.8.40
4.947e-236
735.0
HSJS1_k127_3456433_6
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1458.0
HSJS1_k127_3479400_1
ABC1 family protein, ubiquinone biosynthesis protein
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
5.378e-288
888.0
HSJS1_k127_3479400_20
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
1.088e-304
946.0
HSJS1_k127_3555606_5
flavoprotein involved in K transport
K07222
-
-
3.076e-266
827.0
HSJS1_k127_3555606_6
Uncharacterized protein conserved in bacteria (DUF2236)
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
COG0501 Zn-dependent protease with chaperone function
-
-
-
0.00000000000000000000000000000000000006075
145.0
HSJS1_k127_3651318_17
-
-
-
-
0.000000004935
59.0
HSJS1_k127_3651318_2
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
1.729e-239
745.0
HSJS1_k127_3651318_3
glycosylase
K03575
-
-
2.487e-217
677.0
HSJS1_k127_3651318_4
peptidase
-
-
-
2.483e-216
675.0
HSJS1_k127_3651318_5
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.0
1358.0
HSJS1_k127_3695522_10
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.000000000000000000000000000000006171
128.0
HSJS1_k127_3695522_15
Pilus assembly protein
K02662
-
-
0.000000000000000000000001326
103.0
HSJS1_k127_3695522_2
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
0.0
1099.0
HSJS1_k127_3695522_3
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
0.0
1045.0
HSJS1_k127_3695522_4
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
1.549e-275
849.0
HSJS1_k127_3695522_5
Malate dehydrogenase
K00027,K00029
-
1.1.1.38,1.1.1.40
5.515e-266
821.0
HSJS1_k127_3695522_6
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
The glycine cleavage system catalyzes the degradation of glycine
K00605
-
2.1.2.10
1.189e-213
670.0
HSJS1_k127_3721652_12
Iron deficiency-induced protein A
K02012
-
-
7.479e-207
645.0
HSJS1_k127_3721652_13
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00281,K00283
-
1.4.4.2
3e-322
987.0
HSJS1_k127_3721652_4
iron ABC transporter permease
K02011
-
-
2.04e-294
908.0
HSJS1_k127_3721652_5
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00282
-
1.4.4.2
3.52e-280
863.0
HSJS1_k127_3721652_6
COG2067 Long-chain fatty acid transport protein
-
-
-
2.889e-265
821.0
HSJS1_k127_3721652_7
long-chain fatty acid transporting porin activity
K06076
-
-
1.064e-260
807.0
HSJS1_k127_3721652_8
hydroxylase
K18800
-
-
1.255e-245
762.0
HSJS1_k127_3721652_9
long-chain fatty acid transporting porin activity
K06076
-
-
1.184e-227
711.0
HSJS1_k127_3782686_0
protein containing a von Willebrand factor type A (vWA) domain
K07114
-
-
0.0
1177.0
HSJS1_k127_3782686_1
acetylesterase activity
-
-
-
7.876e-315
967.0
HSJS1_k127_3782686_3
COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000000001526
81.0
HSJS1_k127_382184_0
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1074.0
HSJS1_k127_382184_1
DNA helicase
K03654
-
3.6.4.12
0.0
1012.0
HSJS1_k127_382184_2
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
1.259e-267
826.0
HSJS1_k127_382184_3
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1802.0
HSJS1_k127_3915626_1
of the RND superfamily
K07003
-
-
0.0
1463.0
HSJS1_k127_3915626_10
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
K00254
-
1.3.5.2
1.556e-202
632.0
HSJS1_k127_3915626_11
Histidine kinase
K20975
-
2.7.13.3
5.943e-197
625.0
HSJS1_k127_3915626_12
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
2.567e-195
616.0
HSJS1_k127_3915626_13
COG1629 Outer membrane receptor proteins, mostly Fe transport
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
1.128e-317
976.0
HSJS1_k127_3972929_3
Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
3.083e-311
956.0
HSJS1_k127_3991485_4
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K15576
-
-
9.063e-310
948.0
HSJS1_k127_3991485_5
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
-
-
-
2.606e-296
909.0
HSJS1_k127_3991485_6
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K22067
-
-
6.806e-258
796.0
HSJS1_k127_3991485_7
Alginate export
-
-
-
1.984e-240
747.0
HSJS1_k127_3991485_8
COG0477 Permeases of the major facilitator superfamily
-
-
-
2.502e-218
680.0
HSJS1_k127_3991485_9
ABC-type nitrate sulfonate bicarbonate transport system, permease component
K15577
-
-
5.852e-206
642.0
HSJS1_k127_4008574_0
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1077.0
HSJS1_k127_4022224_1
heptosyltransferase
K02843
-
-
5.893e-218
677.0
HSJS1_k127_4022224_10
Hexapeptide repeat of succinyl-transferase
-
-
-
0.000000000000000000000000000000000000006686
152.0
HSJS1_k127_4022224_11
COG3306 Glycosyltransferase involved in LPS biosynthesis
-
-
-
0.0000000000000000000000000001193
125.0
HSJS1_k127_4022224_2
COG0859 ADP-heptose LPS heptosyltransferase
K02841
-
-
3.951e-201
628.0
HSJS1_k127_4022224_3
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
K00322
-
1.6.1.1
5.785e-303
929.0
HSJS1_k127_4026356_5
MATE efflux family protein
K03327
-
-
4.648e-277
856.0
HSJS1_k127_4026356_6
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
4.577e-259
801.0
HSJS1_k127_4026356_7
COG0477 Permeases of the major facilitator superfamily
-
-
-
1.375e-246
764.0
HSJS1_k127_4026356_8
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.00000000000000000000000000000000000000000002022
161.0
HSJS1_k127_4042249_15
Fe-S protein
K06938
-
-
0.00000000000000000000000000001228
119.0
HSJS1_k127_4042249_16
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01638
-
2.3.3.9
0.0
1439.0
HSJS1_k127_4050768_1
COG2303 Choline dehydrogenase and related flavoproteins
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes
K07712
-
-
0.000000000000000000000000000000009849
126.0
HSJS1_k127_4287703_0
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
0.0
2107.0
HSJS1_k127_4287703_1
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K03583
-
3.1.11.5
0.0
1992.0
HSJS1_k127_4287703_10
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.273e-227
708.0
HSJS1_k127_4287703_11
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
5.033e-223
691.0
HSJS1_k127_4287703_12
luxR family
-
-
-
1.791e-194
613.0
HSJS1_k127_4287703_13
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.00000000000000000000000000000001574
126.0
HSJS1_k127_4287703_26
SIR2-like domain
-
-
-
0.000002439
51.0
HSJS1_k127_4287703_3
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K03581
-
3.1.11.5
0.0
1034.0
HSJS1_k127_4287703_4
involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids
-
-
-
0.0
1032.0
HSJS1_k127_4287703_5
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
3.429e-292
901.0
HSJS1_k127_4287703_6
lysine 2,3-aminomutase
-
-
-
2.601e-286
885.0
HSJS1_k127_4287703_7
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
-
-
-
6.641e-285
882.0
HSJS1_k127_4287703_8
containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
-
-
-
2.87e-279
862.0
HSJS1_k127_4287703_9
COG1960 Acyl-CoA dehydrogenases
-
-
-
3.538e-265
819.0
HSJS1_k127_4295221_0
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05916
-
1.14.12.17
3.239e-237
736.0
HSJS1_k127_430750_5
Diguanylate cyclase
-
-
-
8.815e-236
733.0
HSJS1_k127_430750_6
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
-
-
-
1.009e-210
661.0
HSJS1_k127_430750_7
Phospholipase
K01058
-
3.1.1.32,3.1.1.4
8.116e-202
633.0
HSJS1_k127_430750_8
transcriptional regulator
-
-
-
2.521e-198
619.0
HSJS1_k127_430750_9
COG0720 6-pyruvoyl-tetrahydropterin synthase
-
-
-
1.675e-194
607.0
HSJS1_k127_4315654_0
Long-chain acyl-CoA synthetases (AMP-forming)
K01897
-
6.2.1.3
0.0
1081.0
HSJS1_k127_4315654_1
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
protein involved in exopolysaccharide biosynthesis
-
-
-
0.000000000000117
82.0
HSJS1_k127_4406507_25
-
-
-
-
0.0000000000008312
76.0
HSJS1_k127_4406507_26
Transcriptional regulator
-
-
-
0.000000000001771
79.0
HSJS1_k127_4406507_28
ATPase involved in DNA repair
K21449
-
-
0.0000000004127
73.0
HSJS1_k127_4406507_29
-
-
-
-
0.0000003314
62.0
HSJS1_k127_4406507_3
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1045.0
HSJS1_k127_454681_2
-
-
-
-
0.0
1037.0
HSJS1_k127_454681_3
phosphoserine phosphatase
K01079
-
3.1.3.3
1.704e-245
782.0
HSJS1_k127_454681_4
Pfam Adenylate and Guanylate cyclase catalytic domain
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1766.0
HSJS1_k127_489825_1
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
K03657
-
3.6.4.12
0.0
1446.0
HSJS1_k127_489825_10
-
-
-
-
1.315e-243
758.0
HSJS1_k127_489825_11
Phosphate ABC transporter substrate-binding protein
K02040
-
-
1.21e-220
686.0
HSJS1_k127_489825_12
COG0798 Arsenite efflux pump ACR3 and related permeases
K03325
-
-
2.226e-197
617.0
HSJS1_k127_489825_13
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
probably responsible for the translocation of the substrate across the membrane
K02037
-
-
6.548e-262
811.0
HSJS1_k127_489825_7
TRAP-type mannitol chloroaromatic compound transport system, large permease component
-
-
-
5.87e-259
809.0
HSJS1_k127_489825_8
Phosphate transport system permease
K02038
-
-
6.46e-245
762.0
HSJS1_k127_489825_9
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
-
-
-
2.074e-244
756.0
HSJS1_k127_49390_0
Methionine synthase
K00548
-
2.1.1.13
0.0
2354.0
HSJS1_k127_49390_1
Histidine kinase
-
-
-
0.0
2146.0
HSJS1_k127_49390_10
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454
-
-
8.127e-303
932.0
HSJS1_k127_49390_11
unusual protein kinase
-
-
-
1.116e-279
863.0
HSJS1_k127_49390_12
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K00325
-
1.6.1.2
1.623e-279
861.0
HSJS1_k127_49390_13
ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
1.14e-275
850.0
HSJS1_k127_49390_14
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K02302,K02303
-
1.3.1.76,2.1.1.107,4.99.1.4
5.928e-271
837.0
HSJS1_k127_49390_15
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
6.298e-265
818.0
HSJS1_k127_49390_16
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K00324
-
1.6.1.2
7.497e-237
737.0
HSJS1_k127_49390_17
Uncharacterized protein conserved in bacteria (DUF2236)
-
-
-
3.353e-234
726.0
HSJS1_k127_49390_18
Sensory box protein response regulator
-
-
-
3.318e-229
713.0
HSJS1_k127_49390_19
-
-
-
-
1.954e-228
712.0
HSJS1_k127_49390_2
COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
K03466
-
-
0.0
1472.0
HSJS1_k127_49390_20
membrane protein, required for spore maturation in B.subtilis
-
-
-
4.666e-226
704.0
HSJS1_k127_49390_21
general secretion pathway protein
K02455
-
-
2.056e-225
702.0
HSJS1_k127_49390_22
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.0000000000000000000000000000000000000004362
149.0
HSJS1_k127_49390_6
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Domain of unknown function (DUF5122) beta-propeller
-
-
-
0.000000000000000000000000000003027
128.0
HSJS1_k127_49942_2
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1015.0
HSJS1_k127_49942_3
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
1.475e-256
795.0
HSJS1_k127_49942_4
Chromate
K07240
-
-
6.537e-203
636.0
HSJS1_k127_49942_5
Domain of unknown function (DUF4062)
-
-
-
9.612e-199
621.0
HSJS1_k127_49942_6
COG3555 Aspartyl asparaginyl beta-hydroxylase and related dioxygenases
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1664.0
HSJS1_k127_566054_1
protein conserved in bacteria
K09800
-
-
0.0
1585.0
HSJS1_k127_566054_10
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
3.656e-225
698.0
HSJS1_k127_566054_11
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
4.243e-221
687.0
HSJS1_k127_61098_2
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Rossmann fold nucleotide-binding protein involved in DNA uptake
K04096
-
-
3.582e-203
635.0
HSJS1_k127_671517_1
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1174.0
HSJS1_k127_684007_1
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0
1153.0
HSJS1_k127_684007_2
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.0000000000000000000000000000000008951
130.0
HSJS1_k127_685301_0
amine dehydrogenase activity
-
-
-
0.0
1220.0
HSJS1_k127_685301_1
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
5.12e-290
891.0
HSJS1_k127_685301_6
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02275
-
1.9.3.1
4.412e-262
809.0
HSJS1_k127_685301_7
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K03732
-
3.6.4.13
1.228e-260
805.0
HSJS1_k127_685301_8
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.59e-243
754.0
HSJS1_k127_685301_9
Neuraminidase (sialidase)
-
-
-
3.749e-240
747.0
HSJS1_k127_705050_0
flavoprotein involved in K transport
-
-
-
2.767e-321
985.0
HSJS1_k127_705050_1
COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.0000000000000315
72.0
HSJS1_k127_738781_3
Belongs to the peptidase M16 family
K07263
-
-
1.373e-257
799.0
HSJS1_k127_738781_4
Peptidase, M16
K00960,K07263
-
2.7.7.6
4.18e-257
801.0
HSJS1_k127_738781_5
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03110
-
-
1.352e-208
653.0
HSJS1_k127_738781_6
Part of the ABC transporter FtsEX involved in cellular division
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1590.0
HSJS1_k127_747403_1
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
1.227e-217
677.0
HSJS1_k127_747403_2
Belongs to the histone-like protein H-NS family
K03746
-
-
0.0000000000000000005422
86.0
HSJS1_k127_77338_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1733.0
HSJS1_k127_77338_1
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
1.146e-276
852.0
HSJS1_k127_77338_2
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
6.565e-233
722.0
HSJS1_k127_77338_3
Prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
1.208e-232
721.0
HSJS1_k127_77338_4
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
0.0000000002698
65.0
HSJS1_k127_788229_0
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0
1351.0
HSJS1_k127_788229_1
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1546.0
HSJS1_k127_823169_1
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
0.0
1105.0
HSJS1_k127_823169_10
COG0438 Glycosyltransferase
-
-
-
2.601e-220
688.0
HSJS1_k127_823169_11
Sulfotransferase family
-
-
-
9.054e-214
668.0
HSJS1_k127_823169_12
FR47-like protein
-
-
-
6.72e-211
662.0
HSJS1_k127_823169_13
Belongs to the agmatine deiminase family
-
-
-
1.161e-207
647.0
HSJS1_k127_823169_14
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
K00912
-
2.7.1.130
2.154e-198
620.0
HSJS1_k127_823169_15
Responsible for synthesis of pseudouridine from uracil
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
4.814e-285
877.0
HSJS1_k127_823169_5
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
1.876e-269
830.0
HSJS1_k127_823169_6
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
K00351
-
1.6.5.8
8.044e-268
824.0
HSJS1_k127_823169_7
Lipoprotein releasing system, transmembrane protein
Belongs to the glucose-6-phosphate 1-epimerase family
K01792
-
5.1.3.15
0.0000000004846
59.0
HSJS1_k127_85895_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1717.0
HSJS1_k127_85895_1
(Lipo)protein
K07121
-
-
0.0
1121.0
HSJS1_k127_85895_10
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
6.636e-264
814.0
HSJS1_k127_85895_11
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
1.738e-259
801.0
HSJS1_k127_85895_12
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.616e-253
785.0
HSJS1_k127_85895_13
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
5.854e-244
755.0
HSJS1_k127_85895_14
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
1.698e-241
748.0
HSJS1_k127_85895_15
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
7.031e-234
726.0
HSJS1_k127_85895_16
Reduces the stability of FtsZ polymers in the presence of ATP
K06916
-
-
2.194e-229
711.0
HSJS1_k127_85895_17
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
8.492e-229
709.0
HSJS1_k127_85895_18
long-chain fatty acid transport protein
K06076
-
-
2.453e-228
713.0
HSJS1_k127_85895_19
Belongs to the peptidase S1C family
K04691
-
-
1.087e-223
698.0
HSJS1_k127_85895_2
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum
K03587
-
3.4.16.4
0.0
1097.0
HSJS1_k127_85895_20
type II secretion system protein
K02653
-
-
2.206e-217
679.0
HSJS1_k127_85895_21
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
2.765e-217
681.0
HSJS1_k127_85895_22
Aldo keto reductase
-
-
-
4.014e-215
669.0
HSJS1_k127_85895_23
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.009e-212
664.0
HSJS1_k127_85895_24
COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
K03574
-
3.6.1.55
1.758e-196
614.0
HSJS1_k127_85895_25
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
4.136e-289
887.0
HSJS1_k127_85895_50
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.000000000000000000000000000000000001527
139.0
HSJS1_k127_85895_67
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.00000000000000000000000000000128
120.0
HSJS1_k127_85895_68
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
K03438
-
2.1.1.199
0.000000000000000000000000006663
118.0
HSJS1_k127_85895_69
-
-
-
-
0.00000000000000000000001528
104.0
HSJS1_k127_85895_7
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
7.739e-287
887.0
HSJS1_k127_85895_70
Phosphocarrier protein HPr
K08485,K11189
-
-
0.0000000000000000001943
91.0
HSJS1_k127_85895_8
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
6.672e-278
856.0
HSJS1_k127_85895_9
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
5.442e-267
823.0
HSJS1_k127_961228_2
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the biosynthesis of agmatine from arginine
K01585
-
4.1.1.19
0.0
1210.0
HSJS1_k127_979781_1
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
