it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K02302,K02303
-
1.3.1.76,2.1.1.107,4.99.1.4
8.257e-280
862.0
HSJS1_k127_1124670_2
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
4.29e-275
847.0
HSJS1_k127_1124670_3
ATPase related to the helicase subunit of the Holliday junction resolvase
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K20455
-
4.2.1.117
0.0
1718.0
HSJS1_k127_117028_10
COG0520 Selenocysteine lyase
-
-
-
2.471e-246
761.0
HSJS1_k127_117028_11
Ankyrin repeat
-
-
-
3.127e-245
762.0
HSJS1_k127_117028_12
Belongs to the citrate synthase family
K01659
-
2.3.3.5
6.077e-244
755.0
HSJS1_k127_117028_13
DNA polymerase III subunit delta
K02341
-
2.7.7.7
7.574e-223
691.0
HSJS1_k127_117028_14
Sh3 type 3 domain protein
-
-
-
5.28e-214
666.0
HSJS1_k127_117028_15
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
5.962e-214
668.0
HSJS1_k127_117028_16
Serine aminopeptidase, S33
-
-
-
1.076e-210
654.0
HSJS1_k127_117028_17
GGDEF domain
-
-
-
1.155e-210
659.0
HSJS1_k127_117028_18
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
2.043e-209
652.0
HSJS1_k127_117028_19
in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon
K13634
-
-
1.942e-208
649.0
HSJS1_k127_117028_2
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1592.0
HSJS1_k127_117028_20
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
K03621
-
2.3.1.15
5.186e-206
643.0
HSJS1_k127_117028_21
peptidase
K04773
-
-
1.846e-199
622.0
HSJS1_k127_117028_22
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.000000000000000000000000000000000000007533
145.0
HSJS1_k127_117028_48
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000000000009524
124.0
HSJS1_k127_117028_49
NAD(P)H-binding
-
-
-
0.000000000000000000000000000000258
131.0
HSJS1_k127_117028_5
Long-chain fatty acid transport protein
-
-
-
0.0
1094.0
HSJS1_k127_117028_51
Parallel beta-helix repeats
-
-
-
0.000000000005902
79.0
HSJS1_k127_117028_6
Protein of unknown function (DUF1552)
-
-
-
7.004e-284
873.0
HSJS1_k127_117028_7
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
5.185e-274
844.0
HSJS1_k127_117028_8
COG0147 Anthranilate para-aminobenzoate synthases component I
K01665
-
2.6.1.85
4.84e-262
809.0
HSJS1_k127_117028_9
protein conserved in bacteria
K09788
-
-
3.968e-248
767.0
HSJS1_k127_1181910_0
Tfp pilus assembly protein
K08086
-
-
0.0
1513.0
HSJS1_k127_1181910_1
COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K01703
-
4.2.1.33,4.2.1.35
1.626e-308
947.0
HSJS1_k127_1181910_3
Aldehyde dehydrogenase family
K00135
-
1.2.1.16,1.2.1.20,1.2.1.79
8.252e-293
901.0
HSJS1_k127_1181910_4
Aminotransferase class-III
K00836
-
2.6.1.76
2.628e-272
840.0
HSJS1_k127_1181910_5
peptidase M20
K01436
-
-
3.543e-258
796.0
HSJS1_k127_1181910_6
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
1.527e-245
758.0
HSJS1_k127_1181910_7
COG0006 Xaa-Pro aminopeptidase
K01271
-
3.4.13.9
1.761e-232
727.0
HSJS1_k127_1181910_8
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
4.012e-225
698.0
HSJS1_k127_1181910_9
Universal stress protein family
K14055
-
-
5.066e-197
615.0
HSJS1_k127_1226582_0
Histidine kinase
K20974
-
2.7.13.3
0.0
1472.0
HSJS1_k127_1226582_1
accessory protein
K06959
-
-
0.0
1393.0
HSJS1_k127_1226582_10
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
0.0
1054.0
HSJS1_k127_1226582_4
highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues
K01915
-
6.3.1.2
5.601e-316
968.0
HSJS1_k127_1226582_5
Histidine kinase
K07640
-
2.7.13.3
3.824e-276
850.0
HSJS1_k127_1226582_6
Malate dehydrogenase
K00027,K00029
-
1.1.1.38,1.1.1.40
2.867e-266
823.0
HSJS1_k127_1226582_7
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
1.198e-220
685.0
HSJS1_k127_1226582_8
AI-2E family transporter
-
-
-
1.592e-199
624.0
HSJS1_k127_1226582_9
COG2267 Lysophospholipase
K01048
-
3.1.1.5
3.036e-194
607.0
HSJS1_k127_1233183_0
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
K00557
-
2.1.1.35
3.68e-242
750.0
HSJS1_k127_1244173_4
TRAP-type C4-dicarboxylate transport system periplasmic component
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
3.607e-297
916.0
HSJS1_k127_1313941_0
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
0.0
1206.0
HSJS1_k127_1313941_1
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
-
-
-
0.0
1028.0
HSJS1_k127_1313941_10
HflC and HflK could encode or regulate a protease
K04088
-
-
1.423e-237
736.0
HSJS1_k127_1313941_11
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
2.682e-230
714.0
HSJS1_k127_1313941_12
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
K06949
-
3.1.3.100
1.328e-219
681.0
HSJS1_k127_1313941_13
Flagellar motor protein
K02557
-
-
1.61e-214
667.0
HSJS1_k127_1313941_14
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
1.909e-209
651.0
HSJS1_k127_1313941_15
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily
signal transduction protein containing EAL and modified HD-GYP domains
-
-
-
0.0
1021.0
HSJS1_k127_1313941_20
With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
1.038e-303
936.0
HSJS1_k127_1313941_5
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
1.06e-287
883.0
HSJS1_k127_1313941_6
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
5.327e-272
839.0
HSJS1_k127_1313941_7
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
K00121
-
1.1.1.1,1.1.1.284
1.116e-255
788.0
HSJS1_k127_1313941_8
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
2.987e-250
776.0
HSJS1_k127_1313941_9
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
0.00000000000001078
73.0
HSJS1_k127_1440545_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K07787
-
-
0.0
1962.0
HSJS1_k127_1440545_1
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1951.0
HSJS1_k127_1440545_10
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01950
-
6.3.5.1
0.0
1038.0
HSJS1_k127_1440545_100
Protein of unknown function (DUF465)
K09794
-
-
0.00000000000000000000000000000000000000005672
152.0
HSJS1_k127_1440545_101
regulator of chromosome condensation, RCC1
K12287
-
-
0.0000000000000000000000000000000000000001205
151.0
HSJS1_k127_1440545_103
type IV pilus modification protein PilV
K02671
-
-
0.0000000000000000000000000000000000007427
146.0
HSJS1_k127_1440545_105
Type IV minor pilin ComP, DNA uptake sequence receptor
K02655
-
-
0.000000000000000000000001736
108.0
HSJS1_k127_1440545_107
COG4970 Tfp pilus assembly protein FimT
K08084
-
-
0.0000000000001896
78.0
HSJS1_k127_1440545_108
Type II transport protein GspH
K08084
-
-
0.000000000003965
72.0
HSJS1_k127_1440545_109
N-methylhydantoinase A acetone carboxylase, beta subunit
K01469,K01473
-
3.5.2.14,3.5.2.9
0.000000003101
57.0
HSJS1_k127_1440545_11
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.297e-319
981.0
HSJS1_k127_1440545_111
Type IV Pilus-assembly protein W
K02672
-
-
0.00002238
55.0
HSJS1_k127_1440545_112
Pilus assembly protein PilX
K02673
-
-
0.0001347
51.0
HSJS1_k127_1440545_12
COG0464 ATPases of the AAA class
-
-
-
3.987e-313
960.0
HSJS1_k127_1440545_13
Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
K02667
-
-
1.663e-265
821.0
HSJS1_k127_1440545_17
Outer membrane efflux protein
-
-
-
1.161e-261
809.0
HSJS1_k127_1440545_18
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
7.359e-257
792.0
HSJS1_k127_1440545_19
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
4.469e-252
780.0
HSJS1_k127_1440545_2
alginic acid biosynthetic process
K12287
-
-
0.0
1783.0
HSJS1_k127_1440545_20
Glycosyltransferase Family 4
-
-
-
3.265e-244
756.0
HSJS1_k127_1440545_21
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
8.399e-240
743.0
HSJS1_k127_1440545_22
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
6.177e-238
736.0
HSJS1_k127_1440545_23
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
6.062e-236
730.0
HSJS1_k127_1440545_24
Glycosyltransferase Family 4
-
-
-
2.15e-231
719.0
HSJS1_k127_1440545_25
peptidase M42
-
-
-
5.685e-231
715.0
HSJS1_k127_1440545_26
Peptidoglycan polymerase that is essential for cell wall elongation
K05837
-
-
1.369e-227
707.0
HSJS1_k127_1440545_27
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K02051
-
-
1.647e-220
688.0
HSJS1_k127_1440545_31
Protein of unknown function (DUF3549)
-
-
-
1.142e-216
673.0
HSJS1_k127_1440545_32
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K03644
-
2.8.1.8
5.037e-213
662.0
HSJS1_k127_1440545_33
response regulator
-
-
-
4.168e-209
653.0
HSJS1_k127_1440545_34
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
5.899e-208
647.0
HSJS1_k127_1440545_35
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
3.983e-207
646.0
HSJS1_k127_1440545_36
diguanylate cyclase activity
K18967,K20971
-
2.7.7.65
1.14e-205
641.0
HSJS1_k127_1440545_37
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
0.0
1108.0
HSJS1_k127_1440545_70
Catalyzes a trans-dehydration via an enolate intermediate
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1710.0
HSJS1_k127_180336_1
NADH dehydrogenase
K03885
-
1.6.99.3
8.237e-269
830.0
HSJS1_k127_180336_11
Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K03563
-
-
0.00000000000000000000000000000009864
124.0
HSJS1_k127_180336_12
helix_turn_helix, arabinose operon control protein
-
-
-
0.000000000000000000003801
106.0
HSJS1_k127_180336_13
-
-
-
-
0.0000000007082
61.0
HSJS1_k127_180336_14
-
-
-
-
0.000000002783
60.0
HSJS1_k127_180336_15
-
-
-
-
0.0001754
45.0
HSJS1_k127_180336_2
Belongs to the aspartokinase family
K00928
-
2.7.2.4
7.486e-259
800.0
HSJS1_k127_180336_3
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
0.0000000000000000000000000000000000000000001759
160.0
HSJS1_k127_180336_9
Protein of unknown function (DUF2892)
-
-
-
0.0000000000000000000000000000000002169
132.0
HSJS1_k127_1857248_0
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
0.0
1000.0
HSJS1_k127_1857248_1
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Belongs to the binding-protein-dependent transport system permease family
K11960
-
-
1.393e-310
956.0
HSJS1_k127_1909733_4
branched-chain amino acid
K11959
-
-
5.735e-289
887.0
HSJS1_k127_1909733_5
Belongs to the acetyltransferase family. ArgA subfamily
K14682
-
2.3.1.1
2.938e-277
854.0
HSJS1_k127_1909733_6
Adenylate cyclase
K18446
-
3.6.1.25
7.18e-276
850.0
HSJS1_k127_1909733_7
-
-
-
-
9.376e-272
837.0
HSJS1_k127_1909733_8
Belongs to the peptidase M20A family. ArgE subfamily
K01438
-
3.5.1.16
5.741e-256
789.0
HSJS1_k127_1909733_9
Belongs to the binding-protein-dependent transport system permease family
K11961
-
-
6.07e-246
760.0
HSJS1_k127_1962734_0
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K02837
-
-
2.29e-316
968.0
HSJS1_k127_1962734_1
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
3.679e-277
852.0
HSJS1_k127_1962734_10
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
K00955,K00956
-
2.7.1.25,2.7.7.4
0.000000000000000000000000000009202
119.0
HSJS1_k127_204440_3
Protein of unknown function (DUF1501)
-
-
-
5.529e-285
877.0
HSJS1_k127_204440_4
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
1.234e-266
820.0
HSJS1_k127_204440_5
Protein of unknown function (DUF3570)
-
-
-
5.05e-250
772.0
HSJS1_k127_204440_6
Reduces the stability of FtsZ polymers in the presence of ATP
K06916
-
-
9.628e-238
736.0
HSJS1_k127_204440_7
TRAP-type C4-dicarboxylate transport system periplasmic component
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1494.0
HSJS1_k127_2108834_1
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1277.0
HSJS1_k127_2108834_10
glycyl-tRNA synthetase alpha subunit
K01878
-
6.1.1.14
2.714e-220
683.0
HSJS1_k127_2108834_11
Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
K03274
-
5.1.3.20
2.871e-216
671.0
HSJS1_k127_2108834_12
Alpha/beta hydrolase family
-
-
-
7.728e-194
605.0
HSJS1_k127_2108834_13
Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K03272
-
2.7.1.167,2.7.7.70
2.25e-298
917.0
HSJS1_k127_2108834_6
IG-like fold at C-terminal of FixG, putative oxidoreductase
-
-
-
2.685e-285
878.0
HSJS1_k127_2108834_7
COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
-
-
-
7.817e-267
825.0
HSJS1_k127_2108834_8
transferase
K02527
-
2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15
1.748e-264
816.0
HSJS1_k127_2108834_9
COG1538 Outer membrane protein
K12340
-
-
1.438e-220
692.0
HSJS1_k127_2117180_0
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K02407
-
-
0.0
2341.0
HSJS1_k127_217262_1
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K02406
-
-
0.0
2055.0
HSJS1_k127_217262_2
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.334e-273
843.0
HSJS1_k127_2256338_60
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
K05541
-
-
6.948e-205
639.0
HSJS1_k127_225864_11
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K00758
-
2.4.2.4
1.59e-310
956.0
HSJS1_k127_225864_4
beta-lactamase
K07576
-
-
1.797e-297
913.0
HSJS1_k127_225864_5
GGDEF domain
-
-
-
8.072e-288
893.0
HSJS1_k127_225864_6
protein conserved in bacteria
K09760
-
-
3.316e-279
863.0
HSJS1_k127_225864_7
Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit
K01572
-
4.1.1.3
1.405e-242
751.0
HSJS1_k127_225864_8
Taurine catabolism dioxygenase TauD, TfdA family
-
-
-
1.242e-230
715.0
HSJS1_k127_225864_9
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
K15257
-
-
2.322e-222
689.0
HSJS1_k127_2289818_0
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1917.0
HSJS1_k127_2289818_1
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
0.0
1531.0
HSJS1_k127_2289818_10
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K00145
-
1.2.1.38
1.949e-222
690.0
HSJS1_k127_2289818_11
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K09001
-
2.7.1.170
6.319e-207
646.0
HSJS1_k127_2289818_12
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K00826
-
2.6.1.42
7.707e-204
635.0
HSJS1_k127_2289818_13
binding-protein-dependent transport systems inner membrane component
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
K11076
-
-
1.51e-242
750.0
HSJS1_k127_2289818_9
Required for the activity of the bacterial periplasmic transport system of putrescine
K11069,K11073
-
-
3.817e-232
720.0
HSJS1_k127_2305045_0
catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1147.0
HSJS1_k127_2315211_1
TRAP-type C4-dicarboxylate transport system periplasmic component
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
K03578
-
3.6.4.13
0.0
1594.0
HSJS1_k127_2406809_10
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids
K01897
-
6.2.1.3
0.0
1133.0
HSJS1_k127_2406809_5
Tetratricopeptide repeat
-
-
-
0.0
1128.0
HSJS1_k127_2406809_6
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
0.0
1075.0
HSJS1_k127_2406809_7
Histidine kinase
K10715
-
2.7.13.3
0.0
1034.0
HSJS1_k127_2406809_8
protein conserved in bacteria
K09989
-
-
7.984e-263
809.0
HSJS1_k127_2406809_9
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
K06147
-
-
5.496e-260
803.0
HSJS1_k127_2407936_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1755.0
HSJS1_k127_2407936_1
COG0457 FOG TPR repeat
-
-
-
0.0
1110.0
HSJS1_k127_2407936_10
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
8.062e-245
758.0
HSJS1_k127_2407936_11
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
5.048e-244
755.0
HSJS1_k127_2407936_12
Major facilitator superfamily
K07552
-
-
2.803e-243
753.0
HSJS1_k127_2407936_13
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
3.616e-235
728.0
HSJS1_k127_2407936_14
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
1.136e-231
717.0
HSJS1_k127_2407936_15
Phosphate starvation-inducible protein PhoH
K06217
-
-
2.002e-223
693.0
HSJS1_k127_2407936_16
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
K03438
-
2.1.1.199
1.304e-196
614.0
HSJS1_k127_2407936_17
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K00948
-
2.7.6.1
3.504e-195
610.0
HSJS1_k127_2407936_18
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K03589
-
-
0.00000000000000000004791
100.0
HSJS1_k127_2407936_5
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
1.727e-291
896.0
HSJS1_k127_2407936_6
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
3.339e-291
897.0
HSJS1_k127_2407936_7
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
5.714e-263
813.0
HSJS1_k127_2407936_8
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
9.134e-263
811.0
HSJS1_k127_2407936_9
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
3.885e-255
788.0
HSJS1_k127_244697_0
AcrB/AcrD/AcrF family
-
-
-
0.0
2000.0
HSJS1_k127_244697_1
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1987.0
HSJS1_k127_244697_10
Predicted permease
K07089
-
-
1.446e-237
737.0
HSJS1_k127_244697_11
Outer membrane efflux protein
-
-
-
6.682e-235
734.0
HSJS1_k127_244697_12
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1883.0
HSJS1_k127_244697_21
Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
3.316e-253
782.0
HSJS1_k127_244697_9
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
K02356
-
-
0.000000000000000000002728
93.0
HSJS1_k127_2482178_3
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
4.235e-278
858.0
HSJS1_k127_2482178_4
Major facilitator superfamily
-
-
-
1.495e-273
844.0
HSJS1_k127_2482178_5
phosphoserine phosphatase
K01079
-
3.1.3.3
3.675e-253
782.0
HSJS1_k127_2482178_6
Response regulator containing a CheY-like receiver domain and a GGDEF domain
-
-
-
1.145e-238
739.0
HSJS1_k127_2482178_7
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
K06176
-
5.4.99.27
7.34e-224
694.0
HSJS1_k127_2482178_8
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.446e-211
661.0
HSJS1_k127_2482178_9
lysine 2,3-aminomutase
K19810
-
-
1.973e-199
623.0
HSJS1_k127_2487261_0
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00281,K00283
-
1.4.4.2
0.0
1910.0
HSJS1_k127_2487261_1
Putative diguanylate phosphodiesterase
-
-
-
0.0
1615.0
HSJS1_k127_2487261_10
The glycine cleavage system catalyzes the degradation of glycine
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
K03495
-
-
3.204e-237
734.0
HSJS1_k127_2494863_2
TRANSCRIPTIONal
-
-
-
0.0000000000000004062
82.0
HSJS1_k127_2535134_0
ATPases associated with a variety of cellular activities
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K06917
-
-
5.658e-227
704.0
HSJS1_k127_2626309_13
Barrel-sandwich domain of CusB or HlyD membrane-fusion
-
-
-
2.504e-221
688.0
HSJS1_k127_2626309_14
beta-galactosidase activity
-
-
-
6.432e-216
675.0
HSJS1_k127_2626309_15
Beta-galactosidase
-
-
-
8.728e-210
657.0
HSJS1_k127_2626309_16
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
1.054e-204
639.0
HSJS1_k127_2626309_17
Synthesizes selenophosphate from selenide and ATP
K01008
-
2.7.9.3
4.384e-199
624.0
HSJS1_k127_2626309_18
sterol desaturase
-
-
-
1.213e-194
606.0
HSJS1_k127_2626309_19
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ParD-like antitoxin of type II bacterial toxin-antitoxin system
-
-
-
0.000000000000000000000000005611
111.0
HSJS1_k127_2626309_37
ParE-like toxin of type II bacterial toxin-antitoxin system
-
-
-
0.000000000000000000000002477
106.0
HSJS1_k127_2626309_38
-
-
-
-
0.00000000000000000000001074
109.0
HSJS1_k127_2626309_39
-
-
-
-
0.0000000000000003939
82.0
HSJS1_k127_2626309_4
AMP-binding enzyme C-terminal domain
K01897
-
6.2.1.3
1.157e-296
912.0
HSJS1_k127_2626309_5
Outer membrane efflux protein
-
-
-
1.333e-284
878.0
HSJS1_k127_2626309_6
Alkaline phosphatase
K01113
-
3.1.3.1
2.35e-274
846.0
HSJS1_k127_2626309_7
polysaccharide biosynthetic process
-
-
-
2.446e-271
839.0
HSJS1_k127_2626309_8
Glycosyltransferase Family 4
-
-
-
2.448e-261
807.0
HSJS1_k127_2626309_9
DNA methylase
-
-
-
2.906e-259
818.0
HSJS1_k127_2733760_0
membrane
-
-
-
0.0
2553.0
HSJS1_k127_2733760_1
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1089.0
HSJS1_k127_2733760_10
Belongs to the peptidase S1C family
K04691,K04771,K04772
-
3.4.21.107
3.751e-241
749.0
HSJS1_k127_2733760_11
Aminotransferase class I and II
K00817
-
2.6.1.9
4.426e-224
696.0
HSJS1_k127_2733760_12
Rod shape-determining protein
K03569
-
-
2.751e-214
668.0
HSJS1_k127_2733760_13
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
4.708e-313
959.0
HSJS1_k127_2733760_30
Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
1.227e-311
956.0
HSJS1_k127_2733760_40
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K09774
-
-
0.00000000000000000000003166
106.0
HSJS1_k127_2733760_41
COG1943 Transposase and inactivated derivatives
K07491
-
-
0.0000000000000000004883
86.0
HSJS1_k127_2733760_5
Involved in the processing of the 5'end of 16S rRNA
K08301
-
-
5.335e-305
936.0
HSJS1_k127_2733760_6
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
2.913e-274
844.0
HSJS1_k127_2733760_7
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.351e-270
834.0
HSJS1_k127_2733760_8
Acts as a magnesium transporter
K06213
-
-
2.16e-270
835.0
HSJS1_k127_2733760_9
-
-
-
-
8.576e-252
778.0
HSJS1_k127_2779823_0
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
-
-
-
1.945e-316
971.0
HSJS1_k127_2796078_4
membrane protein involved in D-alanine export
K19294
-
-
1.196e-306
940.0
HSJS1_k127_2796078_5
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
1.276e-288
887.0
HSJS1_k127_2796078_6
regulator
-
-
-
2.251e-285
878.0
HSJS1_k127_2796078_7
Aminotransferase
-
-
-
8.455e-240
747.0
HSJS1_k127_2796078_8
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K08963
-
5.3.1.23
9.966e-209
651.0
HSJS1_k127_2796078_9
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
5.665e-306
940.0
HSJS1_k127_28448_4
Belongs to the phosphatidylserine decarboxylase family
K01613
-
4.1.1.65
1.138e-301
928.0
HSJS1_k127_28448_5
found to be peripherally associated with the inner membrane in Escherichia coli
K03499
-
-
2.116e-289
890.0
HSJS1_k127_28448_6
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K03500
-
2.1.1.176
1.174e-267
827.0
HSJS1_k127_28448_7
Cytochrome P450
-
-
-
2.451e-264
817.0
HSJS1_k127_28448_8
Rossmann fold nucleotide-binding protein involved in DNA uptake
K04096
-
-
1.333e-242
752.0
HSJS1_k127_28448_9
Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
K03406
-
-
7.412e-226
706.0
HSJS1_k127_2845397_0
Subunit R is required for both nuclease and ATPase activities, but not for modification
K01153
-
3.1.21.3
0.0
1213.0
HSJS1_k127_2845397_1
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.00000000000000000000000000000000002832
135.0
HSJS1_k127_2862728_19
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0
1103.0
HSJS1_k127_2883819_2
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
0.0
1014.0
HSJS1_k127_2883819_3
Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
K14267
-
2.6.1.17
7.501e-265
816.0
HSJS1_k127_2883819_4
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1384.0
HSJS1_k127_2968655_10
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
1.388e-245
762.0
HSJS1_k127_2968655_11
Pyridine nucleotide-disulphide oxidoreductase
K05297
-
1.18.1.1
2.906e-237
735.0
HSJS1_k127_2968655_12
Phosphate ABC transporter substrate-binding protein
K02040
-
-
1.415e-216
674.0
HSJS1_k127_2968655_13
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03110
-
-
4.795e-213
667.0
HSJS1_k127_2968655_14
Part of the ABC transporter FtsEX involved in cellular division
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0
1348.0
HSJS1_k127_2968655_20
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.0000000000000000000000000000000000000000001419
159.0
HSJS1_k127_2968655_6
TRAP-type mannitol chloroaromatic compound transport system, large permease component
-
-
-
3.119e-270
835.0
HSJS1_k127_2968655_60
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.000000000000000000000000000000000000001309
148.0
HSJS1_k127_2968655_61
rubredoxin
-
-
-
0.000000000000000000000000000000001938
128.0
HSJS1_k127_2968655_62
there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
K02913
-
-
0.00000000000000000000000007928
107.0
HSJS1_k127_2968655_63
Catalytic LigB subunit of aromatic ring-opening dioxygenase
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
2e-323
990.0
HSJS1_k127_2988915_5
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K01012
-
2.8.1.6
2.368e-225
700.0
HSJS1_k127_2988915_6
Major Facilitator Superfamily
-
-
-
2.339e-220
687.0
HSJS1_k127_2988915_7
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
-
-
-
2.141e-219
680.0
HSJS1_k127_2988915_8
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K00766
-
2.4.2.18
1.098e-209
653.0
HSJS1_k127_2988915_9
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle
K00564
-
2.1.1.172
1.119e-203
635.0
HSJS1_k127_2991069_0
Methionine synthase
K00548
-
2.1.1.13
0.0
2453.0
HSJS1_k127_2991069_1
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1530.0
HSJS1_k127_2991069_10
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K03314
-
-
7.046e-304
934.0
HSJS1_k127_2991069_7
Na -driven multidrug efflux pump
-
-
-
1.248e-280
864.0
HSJS1_k127_2991069_8
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
2.34e-276
851.0
HSJS1_k127_2991069_9
ABC-type oligopeptide transport system, periplasmic component
K13893
-
-
4.985e-274
849.0
HSJS1_k127_3006369_0
transport system, large permease component
-
-
-
0.0
1351.0
HSJS1_k127_3006369_1
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
K02169
-
2.1.1.197
7.004e-293
902.0
HSJS1_k127_3006369_2
COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
-
-
-
6.294e-210
653.0
HSJS1_k127_3006369_3
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
K00652
-
2.3.1.47
1.447e-196
614.0
HSJS1_k127_3006369_4
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
2.359e-224
702.0
HSJS1_k127_3171_4
ATPase components of ABC transporters with duplicated ATPase domains
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
K00658
-
2.3.1.61
5.307e-247
765.0
HSJS1_k127_3381375_6
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
3.264e-240
744.0
HSJS1_k127_3381375_7
signal transduction protein containing EAL and modified HD-GYP domains
-
-
-
6.045e-235
730.0
HSJS1_k127_3381375_8
COG0859 ADP-heptose LPS heptosyltransferase
K02841
-
-
3.538e-212
660.0
HSJS1_k127_3381375_9
Two component signalling adaptor domain
K03415
-
-
3.957e-200
624.0
HSJS1_k127_3383475_1
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
K05592
-
3.6.4.13
0.0
1220.0
HSJS1_k127_3392872_1
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.0000000000000000000000000000000000000002924
149.0
HSJS1_k127_3498049_27
protein conserved in bacteria
K05952
-
-
0.00000000000000000000000000000000000002808
143.0
HSJS1_k127_3498049_3
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
K00322
-
1.6.1.1
1.717e-306
940.0
HSJS1_k127_3498049_4
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
9.237e-246
758.0
HSJS1_k127_3498049_5
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
K05539
-
-
4.487e-217
675.0
HSJS1_k127_3498049_6
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
K11391
-
2.1.1.174
5.929e-211
657.0
HSJS1_k127_3498049_7
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K01595
-
4.1.1.31
0.0
1713.0
HSJS1_k127_3560127_10
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
3.076e-236
733.0
HSJS1_k127_3560127_11
MotA TolQ ExbB proton channel
K03561
-
-
1.204e-211
659.0
HSJS1_k127_3560127_12
Negative regulator of sigma E activity
K03598
-
-
2.655e-197
617.0
HSJS1_k127_3560127_13
Belongs to the cysteine synthase cystathionine beta- synthase family
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1491.0
HSJS1_k127_3560127_30
Belongs to the sigma-70 factor family. ECF subfamily
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
protein related to deoxyribodipyrimidine photolyase
K06876
-
-
0.0
1052.0
HSJS1_k127_3671938_1
Belongs to the DNA photolyase family
K01669
-
4.1.99.3
3.39e-287
883.0
HSJS1_k127_3671938_10
Uncharacterized protein conserved in bacteria (DUF2256)
-
-
-
0.00000000000000000000000000000001333
126.0
HSJS1_k127_3671938_11
Belongs to the UPF0061 (SELO) family
-
-
-
0.0000000000000000000000000000008862
123.0
HSJS1_k127_3671938_2
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K07516
-
1.1.1.35
6.997e-269
829.0
HSJS1_k127_3671938_3
acyl-CoA dehydrogenase
-
-
-
5.225e-240
742.0
HSJS1_k127_3671938_4
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Required for chromosome condensation and partitioning
K03529
-
-
0.0
1764.0
HSJS1_k127_3678588_1
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
3.268e-300
923.0
HSJS1_k127_3678588_2
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
K03528
-
-
8.267e-240
744.0
HSJS1_k127_3719177_0
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
K03657
-
3.6.4.12
0.0
1478.0
HSJS1_k127_3719177_1
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
7.848e-268
825.0
HSJS1_k127_3719177_5
Ammonium transporter
K03320
-
-
2.741e-265
818.0
HSJS1_k127_3719177_6
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
-
-
-
0.000000000000000000000000000000000000005946
152.0
HSJS1_k127_3896794_5
Helix-turn-helix domain
-
-
-
0.00000000000000000000000000000003456
127.0
HSJS1_k127_3896794_6
COG3806 Anti-sigma factor
-
-
-
0.000000000000000000000003462
101.0
HSJS1_k127_3896794_8
-
-
-
-
0.000000000000000000002251
101.0
HSJS1_k127_3901890_0
Diguanylate cyclase
-
-
-
0.0
1436.0
HSJS1_k127_3901890_1
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.0
1010.0
HSJS1_k127_3901890_10
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.0000000000000000000000000000000000001509
141.0
HSJS1_k127_3901890_27
ATP synthase
K02116
-
-
0.0000000000000000000000001553
109.0
HSJS1_k127_3901890_3
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
9.319e-300
920.0
HSJS1_k127_3901890_4
COG0477 Permeases of the major facilitator superfamily
-
-
-
3.466e-249
769.0
HSJS1_k127_3901890_5
Putative amidoligase enzyme (DUF2126)
-
-
-
2.035e-247
764.0
HSJS1_k127_3901890_6
A predicted alpha-helical domain with a conserved ER motif.
-
-
-
1.518e-200
625.0
HSJS1_k127_3901890_7
it plays a direct role in the translocation of protons across the membrane
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1344.0
HSJS1_k127_3909209_3
Phytase
K01083
-
3.1.3.8
0.0
1234.0
HSJS1_k127_3909209_4
Aminotransferase
K00812
-
2.6.1.1
2.609e-255
788.0
HSJS1_k127_3909209_5
Phosphoribosylformylglycinamidine cyclo-ligase
K01933
-
6.3.3.1
1.267e-226
703.0
HSJS1_k127_3909209_6
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
6.026e-221
686.0
HSJS1_k127_3909209_7
UDP-glucose 4-epimerase
K01784
-
5.1.3.2
2.599e-215
670.0
HSJS1_k127_3909209_8
Histidine kinase
-
-
-
5.706e-204
642.0
HSJS1_k127_3909209_9
protein conserved in bacteria
K09938
-
-
1.382e-194
609.0
HSJS1_k127_3939172_0
transporter of a GTP-driven Fe(2 ) uptake system
K04759
-
-
0.0
1490.0
HSJS1_k127_3939172_1
RNB
K01147,K12573
-
3.1.13.1
0.0
1232.0
HSJS1_k127_3939172_10
Metal-dependent hydrolases of the beta-lactamase superfamily III
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18989
-
-
0.0
1948.0
HSJS1_k127_3942029_10
Immune inhibitor A peptidase M6
-
-
-
0.0
1274.0
HSJS1_k127_3942029_11
mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
K15738
-
-
0.0
1234.0
HSJS1_k127_3942029_12
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1160.0
HSJS1_k127_3942029_13
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1154.0
HSJS1_k127_3942029_14
domain, Protein
-
-
-
3.06e-322
1015.0
HSJS1_k127_3942029_15
Protein of unknown function (DUF1329)
-
-
-
3.882e-311
952.0
HSJS1_k127_3942029_16
Deoxyguanosinetriphosphate triphosphohydrolase-like protein
K01129
-
3.1.5.1
3.065e-293
900.0
HSJS1_k127_3942029_17
Transporter associated domain
-
-
-
3.244e-270
834.0
HSJS1_k127_3942029_18
Sodium:solute symporter family
K14393
-
-
6.626e-262
814.0
HSJS1_k127_3942029_19
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
9.302e-254
783.0
HSJS1_k127_3942029_2
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Diadenosine tetraphosphatase and related serine threonine protein
-
-
-
7.328e-218
675.0
HSJS1_k127_3942029_25
transcriptional regulator
-
-
-
1.981e-213
663.0
HSJS1_k127_3942029_26
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
1.073e-212
662.0
HSJS1_k127_3942029_27
hydrolase of the alpha beta-hydrolase fold
K07019
-
-
1.156e-206
644.0
HSJS1_k127_3942029_28
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K18990
-
-
1.96e-200
628.0
HSJS1_k127_3942029_29
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06191
-
-
0.000000000000000000000000000000000000000008264
154.0
HSJS1_k127_3942029_6
Double sensory domain of two-component sensor kinase
-
-
-
0.0
1449.0
HSJS1_k127_3942029_60
membrane protein (homolog of Drosophila rhomboid)
-
-
-
0.0000000000000000000000000003247
121.0
HSJS1_k127_3942029_61
Domain of unknown function (DUF1853)
K09977
-
-
0.00000000000000000000000004887
119.0
HSJS1_k127_3942029_62
-
-
-
-
0.0000000000000000000151
92.0
HSJS1_k127_3942029_63
-
-
-
-
0.0000000000000000004564
90.0
HSJS1_k127_3942029_64
protein conserved in bacteria
K09916
-
-
0.0000000000000005364
80.0
HSJS1_k127_3942029_65
Domain of unknown function (DUF4372)
-
-
-
0.000000000004557
65.0
HSJS1_k127_3942029_66
-
-
-
-
0.00000007305
55.0
HSJS1_k127_3942029_7
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01825
-
1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8
0.0
1404.0
HSJS1_k127_3942029_8
exporters of the RND superfamily
K07003
-
-
0.0
1377.0
HSJS1_k127_3942029_9
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.00000000000000000000000000002126
129.0
HSJS1_k127_4057560_24
Type II secretion system protein B
-
-
-
0.00000000002162
73.0
HSJS1_k127_4057560_25
-
-
-
-
0.00000000003861
64.0
HSJS1_k127_4057560_3
helicase
K03722
-
3.6.4.12
0.0
1414.0
HSJS1_k127_4057560_4
DNA internalization-related competence protein ComEC Rec2
K02238
-
-
0.0
1195.0
HSJS1_k127_4057560_5
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
1.921e-292
899.0
HSJS1_k127_4057560_6
Type II secretory pathway, component ExeA
K02450
-
-
4.197e-281
868.0
HSJS1_k127_4057560_7
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
7.764e-268
827.0
HSJS1_k127_4057560_8
Transcription factor
K18850
-
1.14.11.47
4.058e-263
810.0
HSJS1_k127_4057560_9
Lipoprotein releasing system, transmembrane protein
K09808
-
-
3.262e-252
781.0
HSJS1_k127_4074503_0
Large extracellular alpha-helical protein
K06894
-
-
0.0
3227.0
HSJS1_k127_4074503_1
penicillin-binding protein
K05367
-
2.4.1.129
0.0
1531.0
HSJS1_k127_4074503_10
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000000000000003302
93.0
HSJS1_k127_4074503_11
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K03525
-
2.7.1.33
0.00000000000000001075
92.0
HSJS1_k127_4074503_2
TonB dependent receptor
K02014
-
-
0.0
1320.0
HSJS1_k127_4074503_3
PFAM Ion transport 2
K10716
-
-
2.694e-237
736.0
HSJS1_k127_4074503_4
belongs to the carbohydrate kinase PfkB family
K00847,K00892
-
2.7.1.4,2.7.1.73
1.042e-206
644.0
HSJS1_k127_4074503_5
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K03524
-
6.3.4.15
5.959e-204
636.0
HSJS1_k127_4074503_6
COG1283 Na phosphate symporter
K03324
-
-
1.169e-202
635.0
HSJS1_k127_4074503_7
ABC-type amino acid transport signal transduction systems periplasmic component domain
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.0
1568.0
HSJS1_k127_4074728_1
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
2.653e-220
684.0
HSJS1_k127_4074728_2
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1606.0
HSJS1_k127_4134034_1
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0
1056.0
HSJS1_k127_4134034_10
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.0000000000000000003916
87.0
HSJS1_k127_4134034_2
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
8.958e-238
736.0
HSJS1_k127_4134034_3
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
1.642e-230
715.0
HSJS1_k127_4134034_4
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
2.428e-218
689.0
HSJS1_k127_4134034_5
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
1532.0
HSJS1_k127_419237_10
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
0.0
996.0
HSJS1_k127_419237_11
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
5e-324
998.0
HSJS1_k127_419237_12
COG0659 Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
5.879e-319
981.0
HSJS1_k127_419237_13
COG0348 Polyferredoxin
-
-
-
4.506e-316
967.0
HSJS1_k127_419237_14
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
1.283e-307
944.0
HSJS1_k127_419237_15
ABC-type phosphate transport system, periplasmic component
K02040
-
-
3.334e-293
902.0
HSJS1_k127_419237_16
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
1.289e-292
900.0
HSJS1_k127_419237_17
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
3.175e-285
877.0
HSJS1_k127_419237_18
HipA N-terminal domain
K07154
-
2.7.11.1
2.467e-261
807.0
HSJS1_k127_419237_19
FR47-like protein
-
-
-
1.572e-237
735.0
HSJS1_k127_419237_2
P-type ATPase
K01533
-
3.6.3.4
0.0
1454.0
HSJS1_k127_419237_20
fatty acid desaturase
K00508
-
1.14.19.3
1.285e-231
719.0
HSJS1_k127_419237_21
polysaccharide deacetylase
-
-
-
8.78e-214
666.0
HSJS1_k127_419237_22
AraC family transcriptional regulator
-
-
-
3.157e-211
658.0
HSJS1_k127_419237_23
diguanylate cyclase activity
-
-
-
1.017e-206
647.0
HSJS1_k127_419237_24
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
2580.0
HSJS1_k127_423440_1
Signal transduction histidine kinase
-
-
-
0.0
2151.0
HSJS1_k127_423440_10
helix_turn_helix, arabinose operon control protein
K04033
-
-
8.019e-202
629.0
HSJS1_k127_423440_11
Belongs to the binding-protein-dependent transport system permease family
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455,K11747
-
-
0.0
1122.0
HSJS1_k127_423440_5
Histidine kinase-like ATPases
-
-
-
1.894e-315
970.0
HSJS1_k127_423440_6
With EutC catalyzes the formation of acetaldehyde and ammonia from ethanolamine
K03735
-
4.3.1.7
3.533e-308
944.0
HSJS1_k127_423440_7
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
May be involved in recombinational repair of damaged DNA
K03631
-
-
0.0
1052.0
HSJS1_k127_4286893_3
carbamoyl-phosphate synthetase glutamine chain
K01956
-
6.3.5.5
3.192e-252
778.0
HSJS1_k127_4286893_4
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
5.566e-251
775.0
HSJS1_k127_4286893_5
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
K03308
-
-
1.76e-221
689.0
HSJS1_k127_4286893_6
Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1765.0
HSJS1_k127_4288049_10
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
-
-
-
2.436e-233
723.0
HSJS1_k127_4288049_11
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
9.735e-232
721.0
HSJS1_k127_4288049_12
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K01488,K21053
-
3.5.4.2,3.5.4.4
1.205e-228
708.0
HSJS1_k127_4288049_13
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
3.791e-225
700.0
HSJS1_k127_4288049_14
ABC transporter substrate-binding protein PnrA-like
K02058
-
-
1.111e-224
698.0
HSJS1_k127_4288049_15
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K02051
-
-
1.915e-203
634.0
HSJS1_k127_4288049_16
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
0.0
1693.0
HSJS1_k127_4288049_20
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates
K01637
-
4.1.3.1
0.0
1063.0
HSJS1_k127_4288049_30
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000000000000000000000000002276
142.0
HSJS1_k127_44987_117
Phosphoglycolate phosphatase
K01091
-
3.1.3.18
0.0000000000000000000000000000000000007706
148.0
HSJS1_k127_44987_118
Multiple resistance and pH regulation protein F (MrpF / PhaF)
K05563
-
-
0.0000000000000000000000003725
107.0
HSJS1_k127_44987_12
Tryptophan halogenase
K14257
-
1.14.19.49
0.0
1107.0
HSJS1_k127_44987_120
-
-
-
-
0.000000000005436
67.0
HSJS1_k127_44987_122
Transcriptional regulator
-
-
-
0.0003955
50.0
HSJS1_k127_44987_13
Phosphodiesterase alkaline phosphatase D
K01113
-
3.1.3.1
0.0
1100.0
HSJS1_k127_44987_14
FAD-dependent dehydrogenases
K07137
-
-
0.0
1071.0
HSJS1_k127_44987_15
alkyl hydroperoxide reductase
K03387
-
-
0.0
1000.0
HSJS1_k127_44987_16
flavoprotein involved in K transport
-
-
-
6.676e-318
975.0
HSJS1_k127_44987_17
Catalyzes the ATP-dependent carboxylation of a covalently attached biotin and the transfer of the carboxyl group to pyruvate forming oxaloacetate
K01959
-
6.4.1.1
1.019e-316
971.0
HSJS1_k127_44987_18
glutamate synthase
K00266
-
1.4.1.13,1.4.1.14
6.854e-316
967.0
HSJS1_k127_44987_19
FAD linked oxidase
-
-
-
1.953e-306
940.0
HSJS1_k127_44987_2
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
0.0
1902.0
HSJS1_k127_44987_20
Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
-
-
-
4.838e-305
939.0
HSJS1_k127_44987_21
Cytosol aminopeptidase family, catalytic domain
K01255
-
3.4.11.1
2.941e-303
930.0
HSJS1_k127_44987_22
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
-
-
-
3.929e-303
932.0
HSJS1_k127_44987_23
Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit
K05561
-
-
3.105e-298
917.0
HSJS1_k127_44987_24
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
7.794e-296
908.0
HSJS1_k127_44987_25
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
5.957e-278
857.0
HSJS1_k127_44987_26
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
4.978e-277
852.0
HSJS1_k127_44987_27
ATPases associated with a variety of cellular activities
K05776
-
-
9.185e-274
846.0
HSJS1_k127_44987_28
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
8.776e-264
816.0
HSJS1_k127_44987_29
response regulator receiver
-
-
-
2.591e-263
812.0
HSJS1_k127_44987_3
NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit
K05559
-
-
0.0
1737.0
HSJS1_k127_44987_30
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
1.307e-259
803.0
HSJS1_k127_44987_31
molybdopterin
K03750
-
2.10.1.1
1.407e-250
775.0
HSJS1_k127_44987_32
PFAM Metal-dependent phosphohydrolase, HD
-
-
-
7.77e-242
751.0
HSJS1_k127_44987_33
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
2.807e-236
731.0
HSJS1_k127_44987_34
AAA domain
K03112
-
-
5.426e-232
726.0
HSJS1_k127_44987_35
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
6.18e-232
719.0
HSJS1_k127_44987_36
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K11752
-
1.1.1.193,3.5.4.26
4.615e-229
711.0
HSJS1_k127_44987_37
Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K01735
-
4.2.3.4
2.004e-227
706.0
HSJS1_k127_44987_38
Sh3 type 3 domain protein
-
-
-
5.149e-226
705.0
HSJS1_k127_44987_39
mechanosensitive ion channel
K16052
-
-
1.752e-222
691.0
HSJS1_k127_44987_4
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0
1674.0
HSJS1_k127_44987_40
Pilus assembly protein
K02662
-
-
1.019e-221
689.0
HSJS1_k127_44987_41
oxidoreductase activity
-
-
-
5.01e-221
698.0
HSJS1_k127_44987_42
Uncharacterized protein conserved in bacteria (DUF2236)
-
-
-
2.028e-218
685.0
HSJS1_k127_44987_43
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.0
1468.0
HSJS1_k127_44987_60
Belongs to the short-chain dehydrogenases reductases (SDR) family
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
0.0
1225.0
HSJS1_k127_44987_90
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
protein (some members contain a von Willebrand factor type A (vWA) domain
K02034,K13891
-
-
5.123e-249
770.0
HSJS1_k127_458917_1
ArsR family transcriptional regulator
-
-
-
2.769e-205
641.0
HSJS1_k127_458917_2
ATPase, AAA
K03924
-
-
3.268e-200
625.0
HSJS1_k127_458917_3
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1532.0
HSJS1_k127_51276_1
Methyl-accepting chemotaxis
K03406
-
-
0.0
1394.0
HSJS1_k127_51276_10
response regulator
K10943
-
-
5.196e-289
889.0
HSJS1_k127_51276_11
SRP54-type protein, GTPase domain
K02404
-
-
8.677e-286
879.0
HSJS1_k127_51276_12
Involved in type III protein export during flagellum assembly
K02412
-
3.6.3.14
2.061e-282
869.0
HSJS1_k127_51276_13
forms a homodimer and then a multimeric complex with NrdA
K00526
-
1.17.4.1
1.184e-249
771.0
HSJS1_k127_51276_14
His Kinase A (phosphoacceptor) domain
K10942
-
2.7.13.3
2.913e-240
745.0
HSJS1_k127_51276_15
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K02401
-
-
1.681e-231
718.0
HSJS1_k127_51276_16
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02410
-
-
5.048e-204
636.0
HSJS1_k127_51276_17
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
6.02e-204
636.0
HSJS1_k127_51276_18
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
6.605e-204
636.0
HSJS1_k127_51276_19
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02416
-
-
1.744e-203
634.0
HSJS1_k127_51276_2
Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K02400
-
-
0.0
1369.0
HSJS1_k127_51276_20
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1689.0
HSJS1_k127_562708_1
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the
K09780
-
-
0.0000000000000003463
79.0
HSJS1_k127_562708_3
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
2.266e-277
854.0
HSJS1_k127_562708_4
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
3.054e-265
817.0
HSJS1_k127_562708_5
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K19804
-
-
2.073e-252
779.0
HSJS1_k127_562708_6
G-rich domain on putative tyrosine kinase
K05789
-
-
7.44e-238
736.0
HSJS1_k127_562708_7
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.56e-235
729.0
HSJS1_k127_562708_8
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.0000000001803
62.0
HSJS1_k127_725610_4
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K15461
-
2.1.1.61
0.0
1313.0
HSJS1_k127_729193_10
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
5.948e-290
924.0
HSJS1_k127_729193_11
MreB/Mbl protein
K04046
-
-
6.581e-274
845.0
HSJS1_k127_729193_12
COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
K09015
-
-
7.558e-270
833.0
HSJS1_k127_729193_13
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
4.095e-260
803.0
HSJS1_k127_729193_14
membrane
K07058
-
-
5.39e-242
751.0
HSJS1_k127_729193_15
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
1.894e-237
735.0
HSJS1_k127_729193_16
nucleoid-associated protein
K06899
-
-
1.033e-236
734.0
HSJS1_k127_729193_17
ATP-NAD kinase
-
-
-
1.421e-235
729.0
HSJS1_k127_729193_18
COG0477 Permeases of the major facilitator superfamily
K05820
-
-
2.954e-235
731.0
HSJS1_k127_729193_19
Belongs to the ompA family
K03286
-
-
1.168e-227
709.0
HSJS1_k127_729193_2
Histidine kinase
-
-
-
0.0
1289.0
HSJS1_k127_729193_21
amino acid aldolase or racemase
-
-
-
3.282e-221
691.0
HSJS1_k127_729193_22
Phospholipase
K01058
-
3.1.1.32,3.1.1.4
7.456e-215
668.0
HSJS1_k127_729193_23
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
1.537e-214
667.0
HSJS1_k127_729193_24
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2275.0
HSJS1_k127_746115_1
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1650.0
HSJS1_k127_746115_10
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
1.466e-313
961.0
HSJS1_k127_746115_102
peptidase
-
-
-
0.0000000000000000000000000000006829
138.0
HSJS1_k127_746115_103
Domain of unknown function (DUF4157)
-
-
-
0.00000000000000000000000000006143
137.0
HSJS1_k127_746115_104
Thioesterase
K01075,K07107
-
3.1.2.23
0.0000000000000000000000000002905
120.0
HSJS1_k127_746115_105
TonB C terminal
K03646
-
-
0.000000000005482
76.0
HSJS1_k127_746115_106
-
-
-
-
0.0000002518
54.0
HSJS1_k127_746115_107
-
-
-
-
0.0000003243
53.0
HSJS1_k127_746115_108
COG1943 Transposase and inactivated derivatives
-
-
-
0.0000007645
51.0
HSJS1_k127_746115_109
-
-
-
-
0.0000007917
52.0
HSJS1_k127_746115_11
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
6.538e-287
882.0
HSJS1_k127_746115_12
COG1960 Acyl-CoA dehydrogenases
-
-
-
8.387e-285
875.0
HSJS1_k127_746115_13
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
4.734e-278
862.0
HSJS1_k127_746115_14
Involved in the TonB-independent uptake of proteins
K03641
-
-
1.172e-277
854.0
HSJS1_k127_746115_15
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
K00351
-
1.6.5.8
5.865e-271
834.0
HSJS1_k127_746115_16
Glycosyl transferase
K13693
-
2.4.1.266
2.185e-269
829.0
HSJS1_k127_746115_17
Thiamine-phosphate pyrophosphorylase
K00941,K14153
-
2.5.1.3,2.7.1.49,2.7.4.7
1.749e-268
833.0
HSJS1_k127_746115_18
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
3.995e-265
816.0
HSJS1_k127_746115_19
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
4.088e-256
790.0
HSJS1_k127_746115_2
Histidine kinase
-
-
-
0.0
1507.0
HSJS1_k127_746115_20
Fatty acid desaturase
K00507
-
1.14.19.1
6.788e-254
783.0
HSJS1_k127_746115_21
protein of Photorhabdus and some similarities with
-
-
-
1.232e-240
782.0
HSJS1_k127_746115_22
MacB-like periplasmic core domain
K02004
-
-
7.6e-239
743.0
HSJS1_k127_746115_23
amine dehydrogenase activity
-
-
-
3.363e-235
746.0
HSJS1_k127_746115_24
MacB-like periplasmic core domain
K02004
-
-
6.505e-234
726.0
HSJS1_k127_746115_25
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K01589
-
6.3.4.18
2.43e-225
699.0
HSJS1_k127_746115_26
Histidine kinase
-
-
-
1.144e-224
698.0
HSJS1_k127_746115_27
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
4.589e-220
683.0
HSJS1_k127_746115_28
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K02005
-
-
5.01e-220
685.0
HSJS1_k127_746115_29
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
2.29e-218
678.0
HSJS1_k127_746115_3
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
0.0
1338.0
HSJS1_k127_746115_30
phage tail tape measure protein
-
-
-
5.746e-214
728.0
HSJS1_k127_746115_31
FAD dependent oxidoreductase
K03153
-
1.4.3.19
6.508e-212
664.0
HSJS1_k127_746115_32
Permease
K03548
-
-
7.038e-210
654.0
HSJS1_k127_746115_33
protein of Photorhabdus and some similarities with
-
-
-
3.959e-207
688.0
HSJS1_k127_746115_34
AraC family transcriptional regulator
-
-
-
8.394e-204
636.0
HSJS1_k127_746115_35
GGDEF domain
-
-
-
9.416e-201
626.0
HSJS1_k127_746115_36
COG4240 Predicted kinase
K15918
-
2.7.1.31
1.501e-198
621.0
HSJS1_k127_746115_37
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K03581
-
3.1.11.5
0.0
1047.0
HSJS1_k127_756340_3
PFAM glycosyl transferase family 39
-
-
-
1e-323
993.0
HSJS1_k127_756340_4
catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP
K00647
-
2.3.1.41
3.491e-252
779.0
HSJS1_k127_756340_5
Acid phosphatase homologues
-
-
-
0.00000000000000000000000000004437
126.0
HSJS1_k127_756340_6
Glycosyl transferase family 2
K20534
-
-
0.00000000000000003459
85.0
HSJS1_k127_768002_0
COG1629 Outer membrane receptor proteins, mostly Fe transport
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1831.0
HSJS1_k127_794250_1
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
K01869
-
6.1.1.4
0.0
1721.0
HSJS1_k127_794250_10
Membrane protein required for beta-lactamase induction
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.00000000000000000000000000000000000001163
144.0
HSJS1_k127_794250_27
Belongs to the N-Me-Phe pilin family
K02650,K02655
-
-
0.000000000000000002903
91.0
HSJS1_k127_794250_3
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.0
1069.0
HSJS1_k127_794250_4
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
9.717e-309
949.0
HSJS1_k127_794250_5
alanine symporter
K03310
-
-
2.833e-281
866.0
HSJS1_k127_794250_6
type II secretion system protein
K02653
-
-
4.553e-239
742.0
HSJS1_k127_794250_7
GGDEF domain
-
-
-
5.297e-237
735.0
HSJS1_k127_794250_8
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
0.0
1558.0
HSJS1_k127_832188_1
PrkA family serine protein kinase
K07180
-
-
0.0
1284.0
HSJS1_k127_832188_10
phosphotransferase related to Ser Thr protein
K07102
-
2.7.1.221
2.547e-215
669.0
HSJS1_k127_832188_11
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K00097
-
1.1.1.262
1.669e-201
629.0
HSJS1_k127_832188_12
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1356.0
HSJS1_k127_8598_1
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
7.021e-313
979.0
HSJS1_k127_8598_3
Participates in both transcription termination and antitermination
K02600
-
-
1.267e-310
953.0
HSJS1_k127_8598_4
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.01e-284
875.0
HSJS1_k127_8598_5
differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
K00648,K16872
-
2.3.1.180,2.3.1.207
2.656e-240
743.0
HSJS1_k127_8598_6
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
0.0
1012.0
HSJS1_k127_967954_5
protein conserved in bacteria
-
-
-
6.52e-321
987.0
HSJS1_k127_967954_6
carnitine dehydratase
-
-
-
2.915e-259
799.0
HSJS1_k127_967954_7
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
