Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
5.185e-274
844.0
HSJS3_k127_10018034_1
COG0147 Anthranilate para-aminobenzoate synthases component I
in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon
K13634
-
-
1.942e-208
649.0
HSJS3_k127_10018034_3
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
K00955,K00956
-
2.7.1.25,2.7.7.4
0.0
1058.0
HSJS3_k127_10024186_1
Reduces the stability of FtsZ polymers in the presence of ATP
K06916
-
-
9.628e-238
736.0
HSJS3_k127_10024186_2
Sulfate adenylyltransferase subunit 2
K00957
-
2.7.7.4
1.3e-199
623.0
HSJS3_k127_10024186_3
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1901.0
HSJS3_k127_104245_1
Putative diguanylate phosphodiesterase
K21025
-
-
0.0
1324.0
HSJS3_k127_104245_10
Major facilitator superfamily
-
-
-
1.495e-273
844.0
HSJS3_k127_104245_11
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
5.327e-272
839.0
HSJS3_k127_104245_12
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
K00121
-
1.1.1.1,1.1.1.284
1.116e-255
788.0
HSJS3_k127_104245_13
phosphoserine phosphatase
K01079
-
3.1.3.3
3.675e-253
782.0
HSJS3_k127_104245_14
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
2.987e-250
776.0
HSJS3_k127_104245_15
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K02502
-
-
7.84e-249
769.0
HSJS3_k127_104245_16
Response regulator containing a CheY-like receiver domain and a GGDEF domain
-
-
-
1.145e-238
739.0
HSJS3_k127_104245_17
HflC and HflK could encode or regulate a protease
K04088
-
-
1.423e-237
736.0
HSJS3_k127_104245_18
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
2.682e-230
714.0
HSJS3_k127_104245_19
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
K06176
-
5.4.99.27
7.34e-224
694.0
HSJS3_k127_104245_2
-
-
-
-
0.0
1204.0
HSJS3_k127_104245_20
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
K06949
-
3.1.3.100
1.328e-219
681.0
HSJS3_k127_104245_21
Flagellar motor protein
K02557
-
-
1.61e-214
667.0
HSJS3_k127_104245_22
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.446e-211
661.0
HSJS3_k127_104245_23
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
1.909e-209
651.0
HSJS3_k127_104245_24
lysine 2,3-aminomutase
K19810
-
-
1.44e-199
623.0
HSJS3_k127_104245_25
RNA polymerase sigma factor RpoS
K03087
-
-
1.459e-194
609.0
HSJS3_k127_104245_26
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
-
-
-
0.0
1028.0
HSJS3_k127_104245_40
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.00000000003664
64.0
HSJS3_k127_104245_57
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K09880
-
3.1.3.77
0.0000000909
54.0
HSJS3_k127_104245_6
Type VI secretion system, VipA, VC_A0107 or Hcp2
K11900
-
-
1.619e-311
956.0
HSJS3_k127_104245_7
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
1.038e-303
936.0
HSJS3_k127_104245_8
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
1.06e-287
883.0
HSJS3_k127_104245_9
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
4.235e-278
858.0
HSJS3_k127_10462529_0
Pyridine nucleotide-disulphide oxidoreductase
K17218
-
1.8.5.4
2.371e-281
865.0
HSJS3_k127_10462529_1
Mediates influx of magnesium ions
K03284
-
-
4.86e-206
642.0
HSJS3_k127_10511423_0
Polysaccharide biosynthesis protein
-
-
-
4.074e-249
777.0
HSJS3_k127_120441_0
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
2580.0
HSJS3_k127_120441_1
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP
K00647
-
2.3.1.41
3.491e-252
779.0
HSJS3_k127_125760_4
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
1534.0
HSJS3_k127_1342749_1
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K03307,K11928
-
-
6.728e-245
764.0
HSJS3_k127_1342749_14
COG1538 Outer membrane protein
K12340
-
-
1.438e-220
692.0
HSJS3_k127_1342749_15
glycyl-tRNA synthetase alpha subunit
K01878
-
6.1.1.14
2.714e-220
683.0
HSJS3_k127_1342749_16
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
4.136e-217
674.0
HSJS3_k127_1342749_17
Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
K03274
-
5.1.3.20
1.116e-216
672.0
HSJS3_k127_1342749_18
Gluconolactonase
-
-
-
5.661e-211
657.0
HSJS3_k127_1342749_19
Alpha/beta hydrolase family
-
-
-
7.728e-194
605.0
HSJS3_k127_1342749_2
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1277.0
HSJS3_k127_1342749_20
Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0
1014.0
HSJS3_k127_1349185_4
Diguanylate cyclase
K13590
-
2.7.7.65
1.438e-319
982.0
HSJS3_k127_1349185_5
TonB dependent receptor
-
-
-
3.511e-314
966.0
HSJS3_k127_1349185_6
Subtilase family
-
-
-
1.172e-250
779.0
HSJS3_k127_1349185_7
Putative zinc-binding metallo-peptidase
-
-
-
1.498e-243
752.0
HSJS3_k127_1349185_8
Transglutaminase-like superfamily
-
-
-
5.086e-236
731.0
HSJS3_k127_1349185_9
belongs to the glycosyl hydrolase 13 family
-
-
-
3.102e-231
719.0
HSJS3_k127_1355691_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18989
-
-
0.0
1948.0
HSJS3_k127_1355691_1
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01825
-
1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8
0.0
1404.0
HSJS3_k127_1355691_2
mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
K15738
-
-
0.0
1234.0
HSJS3_k127_1355691_3
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
9.302e-254
783.0
HSJS3_k127_1355691_4
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1356.0
HSJS3_k127_1394715_1
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
1.068e-313
981.0
HSJS3_k127_1394715_3
Participates in both transcription termination and antitermination
K02600
-
-
1.267e-310
953.0
HSJS3_k127_1394715_4
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.01e-284
875.0
HSJS3_k127_1394715_5
differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
K00648,K16872
-
2.3.1.180,2.3.1.207
2.656e-240
743.0
HSJS3_k127_1394715_6
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
9.346e-277
852.0
HSJS3_k127_1398111_20
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
0.0
1012.0
HSJS3_k127_1407204_4
protein conserved in bacteria
-
-
-
6.52e-321
987.0
HSJS3_k127_1407204_5
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
5.147e-279
861.0
HSJS3_k127_1407204_6
carnitine dehydratase
-
-
-
2.915e-259
799.0
HSJS3_k127_1407204_7
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
2.078e-256
791.0
HSJS3_k127_1407204_8
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
1.101e-248
767.0
HSJS3_k127_1407204_9
Glycosyl transferases group 1
-
-
-
3.743e-237
736.0
HSJS3_k127_1438917_0
COG1629 Outer membrane receptor proteins, mostly Fe transport
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K02407
-
-
0.0
2341.0
HSJS3_k127_155036_1
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K02406
-
-
0.0
2055.0
HSJS3_k127_155036_10
The M ring may be actively involved in energy transduction
K02409
-
-
0.0
1037.0
HSJS3_k127_155036_11
Belongs to the class-II aminoacyl-tRNA synthetase family
COG2148 Sugar transferases involved in lipopolysaccharide synthesis
K03606,K21303
-
2.7.8.40
7.118e-298
915.0
HSJS3_k127_155036_15
exonuclease of the beta-lactamase fold involved in RNA processing
K07576
-
-
1.674e-296
912.0
HSJS3_k127_155036_16
response regulator
K10943
-
-
5.196e-289
889.0
HSJS3_k127_155036_17
SRP54-type protein, GTPase domain
K02404
-
-
8.677e-286
879.0
HSJS3_k127_155036_18
Involved in type III protein export during flagellum assembly
K02412
-
3.6.3.14
2.061e-282
869.0
HSJS3_k127_155036_19
forms a homodimer and then a multimeric complex with NrdA
K00526
-
1.17.4.1
1.184e-249
771.0
HSJS3_k127_155036_2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1532.0
HSJS3_k127_155036_20
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K00012
-
1.1.1.22
8.526e-247
763.0
HSJS3_k127_155036_21
His Kinase A (phosphoacceptor) domain
K10942
-
2.7.13.3
1.407e-239
743.0
HSJS3_k127_155036_22
Putative beta-barrel porin 2
K20920
-
-
4.093e-239
741.0
HSJS3_k127_155036_23
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K02401
-
-
1.681e-231
718.0
HSJS3_k127_155036_24
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02410
-
-
5.048e-204
636.0
HSJS3_k127_155036_25
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
6.02e-204
636.0
HSJS3_k127_155036_26
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
6.605e-204
636.0
HSJS3_k127_155036_27
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02416
-
-
1.744e-203
634.0
HSJS3_k127_155036_28
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
2.25e-202
632.0
HSJS3_k127_155036_29
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K00549
-
2.1.1.14
0.0
1472.0
HSJS3_k127_166240_1
-
-
-
-
1.952e-264
815.0
HSJS3_k127_166240_2
Predicted permease
K07089
-
-
1.446e-237
737.0
HSJS3_k127_166240_3
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
K03466
-
-
0.0000000000000000009219
85.0
HSJS3_k127_1833944_0
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1917.0
HSJS3_k127_1833944_1
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
0.0
1530.0
HSJS3_k127_1833944_10
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K09001
-
2.7.1.170
6.319e-207
646.0
HSJS3_k127_1833944_11
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K00826
-
2.6.1.42
7.707e-204
635.0
HSJS3_k127_1833944_12
binding-protein-dependent transport systems inner membrane component
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
2.066e-277
854.0
HSJS3_k127_1833944_6
Peptidase M23
-
-
-
2.971e-272
839.0
HSJS3_k127_1833944_7
Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
K11076
-
-
1.51e-242
750.0
HSJS3_k127_1833944_8
Required for the activity of the bacterial periplasmic transport system of putrescine
K11069,K11073
-
-
3.817e-232
720.0
HSJS3_k127_1833944_9
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K00145
-
1.2.1.38
1.949e-222
690.0
HSJS3_k127_186529_0
Belongs to the ompA family
-
-
-
2.633e-311
968.0
HSJS3_k127_186529_1
Domain of unknown function (DUF4915)
-
-
-
3.922e-267
821.0
HSJS3_k127_186529_10
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
6.014e-214
664.0
HSJS3_k127_1877625_1
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K01251
-
3.3.1.1
0.0000000000000000000000000000000000002986
141.0
HSJS3_k127_1898907_0
Belongs to the 'phage' integrase family
-
-
-
1.453e-264
816.0
HSJS3_k127_1898907_1
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K00937
-
2.7.4.1
0.0
1410.0
HSJS3_k127_2145884_1
Dicarboxylate transport
-
-
-
0.0
1142.0
HSJS3_k127_2145884_2
Belongs to the GppA Ppx family
K01524
-
3.6.1.11,3.6.1.40
2.147e-312
959.0
HSJS3_k127_2145884_3
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
7.848e-268
825.0
HSJS3_k127_2145884_4
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
-
-
-
1.926e-235
728.0
HSJS3_k127_2145884_5
Belongs to the ALAD family
K01698
-
4.2.1.24
4.103e-214
667.0
HSJS3_k127_2145884_6
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K00372
-
-
0.0
1844.0
HSJS3_k127_224394_1
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K00362
-
1.7.1.15
0.0
1721.0
HSJS3_k127_224394_10
-
-
-
-
0.00000004314
55.0
HSJS3_k127_224394_11
Type VI secretion system (T6SS), amidase effector protein 4
-
-
-
0.000002205
50.0
HSJS3_k127_224394_2
Serine Threonine protein
-
-
-
0.0
1174.0
HSJS3_k127_224394_3
Nitrate nitrite transporter
K02575
-
-
5.14e-312
957.0
HSJS3_k127_224394_4
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03169
-
5.99.1.2
2.404e-206
644.0
HSJS3_k127_2680767_0
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2275.0
HSJS3_k127_2680767_1
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1650.0
HSJS3_k127_2680767_10
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
1.466e-313
961.0
HSJS3_k127_2680767_100
Phage baseplate assembly protein W
K06903
-
-
0.0000000000000000000000000000000000000873
145.0
HSJS3_k127_2680767_103
peptidase
-
-
-
0.0000000000000000000000000000006829
138.0
HSJS3_k127_2680767_104
Domain of unknown function (DUF4157)
-
-
-
0.0000000000000000000000000000159
139.0
HSJS3_k127_2680767_105
Thioesterase
K01075,K07107
-
3.1.2.23
0.0000000000000000000000000002905
120.0
HSJS3_k127_2680767_106
TonB C terminal
K03646
-
-
0.000000000005482
76.0
HSJS3_k127_2680767_107
-
-
-
-
0.0000002518
54.0
HSJS3_k127_2680767_108
-
-
-
-
0.0000003243
53.0
HSJS3_k127_2680767_109
-
-
-
-
0.0000007917
52.0
HSJS3_k127_2680767_11
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
6.538e-287
882.0
HSJS3_k127_2680767_111
COG1943 Transposase and inactivated derivatives
-
-
-
0.000001995
50.0
HSJS3_k127_2680767_12
COG1960 Acyl-CoA dehydrogenases
-
-
-
8.387e-285
875.0
HSJS3_k127_2680767_13
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
4.734e-278
862.0
HSJS3_k127_2680767_14
Involved in the TonB-independent uptake of proteins
K03641
-
-
1.172e-277
854.0
HSJS3_k127_2680767_15
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
K00351
-
1.6.5.8
5.865e-271
834.0
HSJS3_k127_2680767_16
Glycosyl transferase
K13693
-
2.4.1.266
2.185e-269
829.0
HSJS3_k127_2680767_17
Thiamine-phosphate pyrophosphorylase
K00941,K14153
-
2.5.1.3,2.7.1.49,2.7.4.7
1.749e-268
833.0
HSJS3_k127_2680767_18
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
3.995e-265
816.0
HSJS3_k127_2680767_19
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
4.088e-256
790.0
HSJS3_k127_2680767_2
Histidine kinase
-
-
-
0.0
1504.0
HSJS3_k127_2680767_20
Fatty acid desaturase
K00507
-
1.14.19.1
6.788e-254
783.0
HSJS3_k127_2680767_21
protein of Photorhabdus and some similarities with
-
-
-
1.232e-240
782.0
HSJS3_k127_2680767_22
MacB-like periplasmic core domain
K02004
-
-
7.6e-239
743.0
HSJS3_k127_2680767_23
amine dehydrogenase activity
-
-
-
3.363e-235
746.0
HSJS3_k127_2680767_24
MacB-like periplasmic core domain
K02004
-
-
6.505e-234
726.0
HSJS3_k127_2680767_25
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K01589
-
6.3.4.18
2.43e-225
699.0
HSJS3_k127_2680767_26
Histidine kinase
-
-
-
1.144e-224
698.0
HSJS3_k127_2680767_27
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
4.589e-220
683.0
HSJS3_k127_2680767_28
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K02005
-
-
5.01e-220
685.0
HSJS3_k127_2680767_29
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
2.29e-218
678.0
HSJS3_k127_2680767_3
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
0.0
1338.0
HSJS3_k127_2680767_30
phage tail tape measure protein
-
-
-
4.386e-214
729.0
HSJS3_k127_2680767_31
FAD dependent oxidoreductase
K03153
-
1.4.3.19
2.292e-211
662.0
HSJS3_k127_2680767_32
Permease
K03548
-
-
7.038e-210
654.0
HSJS3_k127_2680767_33
protein of Photorhabdus and some similarities with
-
-
-
2.909e-207
688.0
HSJS3_k127_2680767_34
AraC family transcriptional regulator
-
-
-
8.394e-204
636.0
HSJS3_k127_2680767_35
GGDEF domain
-
-
-
9.416e-201
626.0
HSJS3_k127_2680767_36
COG4240 Predicted kinase
K15918
-
2.7.1.31
1.501e-198
621.0
HSJS3_k127_2680767_37
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1491.0
HSJS3_k127_2691883_30
Belongs to the SlyX family
K03745
-
-
0.00000000000000000000000000000000000000007209
151.0
HSJS3_k127_2691883_31
Negative regulator of sigma E activity
K03598
-
-
0.00000000000000000000000000000000000001596
144.0
HSJS3_k127_2691883_32
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
K00997
-
2.7.8.7
0.000000000000000000000003377
107.0
HSJS3_k127_2691883_4
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
2.441e-252
778.0
HSJS3_k127_2691883_7
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
3.076e-236
733.0
HSJS3_k127_2691883_8
Belongs to the cysteine synthase cystathionine beta- synthase family
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
1.111e-289
923.0
HSJS3_k127_2725992_50
Phosphate-starvation-inducible E
-
-
-
0.000000000000000000000000000000000000000006782
155.0
HSJS3_k127_2725992_52
helix_turn_helix multiple antibiotic resistance protein
-
-
-
0.00000000000000000000000005863
112.0
HSJS3_k127_2725992_6
MreB/Mbl protein
K04046
-
-
6.581e-274
845.0
HSJS3_k127_2725992_7
COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
K09015
-
-
7.558e-270
833.0
HSJS3_k127_2725992_8
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
4.095e-260
803.0
HSJS3_k127_2725992_9
nucleoid-associated protein
K06899
-
-
1.033e-236
734.0
HSJS3_k127_2750982_0
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K01426
-
3.5.1.4
8.127e-237
734.0
HSJS3_k127_2755965_0
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00281,K00283
-
1.4.4.2
0.0
1913.0
HSJS3_k127_2755965_1
Putative diguanylate phosphodiesterase
-
-
-
0.0
1617.0
HSJS3_k127_2755965_10
COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
-
-
-
6.294e-210
653.0
HSJS3_k127_2755965_11
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
-
-
-
0.0
1142.0
HSJS3_k127_2755965_7
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1384.0
HSJS3_k127_2806714_1
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0
1348.0
HSJS3_k127_2806714_10
Catalytic LigB subunit of aromatic ring-opening dioxygenase
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.000000000000000000000000000000000000001309
148.0
HSJS3_k127_2806714_22
rubredoxin
-
-
-
0.000000000000000000000000000000001938
128.0
HSJS3_k127_2806714_23
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K00989
-
2.7.7.56
0.000000005667
58.0
HSJS3_k127_2806714_24
Catalytic LigB subunit of aromatic ring-opening dioxygenase
-
-
-
0.00000003294
55.0
HSJS3_k127_2806714_3
Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
0.0
1558.0
HSJS3_k127_2948047_1
PrkA family serine protein kinase
K07180
-
-
0.0
1284.0
HSJS3_k127_2948047_10
phosphotransferase related to Ser Thr protein
K07102
-
2.7.1.221
2.547e-215
669.0
HSJS3_k127_2948047_11
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K00097
-
1.1.1.262
1.669e-201
629.0
HSJS3_k127_2948047_12
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Catalyzes the reversible hydration of fumarate to (S)- malate
K01676
-
4.2.1.2
0.0
1024.0
HSJS3_k127_2948047_7
Belongs to the alkaline phosphatase family
K01077
-
3.1.3.1
3.1e-322
992.0
HSJS3_k127_2948047_8
Rossmann fold nucleotide-binding protein
K06966
-
3.2.2.10
7.473e-297
911.0
HSJS3_k127_2948047_9
-
-
-
-
3.959e-228
707.0
HSJS3_k127_2953979_0
Lamin Tail Domain
K07004
-
-
0.0
1748.0
HSJS3_k127_2953979_1
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
1.158e-298
917.0
HSJS3_k127_2953979_10
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.0000000000000000000000000000000000000000004874
157.0
HSJS3_k127_2953979_11
Cobalamin synthesis protein cobW C-terminal domain
catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
K01624
-
4.1.2.13
4.805e-233
721.0
HSJS3_k127_3119888_3
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1027.0
HSJS3_k127_3144422_1
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
8.958e-238
736.0
HSJS3_k127_3144422_2
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
1.642e-230
715.0
HSJS3_k127_3144422_3
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
2.428e-218
689.0
HSJS3_k127_3214721_0
protein (some members contain a von Willebrand factor type A (vWA) domain
K02034,K13891
-
-
5.123e-249
770.0
HSJS3_k127_3214721_1
ArsR family transcriptional regulator
-
-
-
2.769e-205
641.0
HSJS3_k127_3214721_2
ATPase, AAA
K03924
-
-
1.27e-200
627.0
HSJS3_k127_3214721_3
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.0000000000000000000000000000000000000002924
149.0
HSJS3_k127_326501_27
protein conserved in bacteria
K05952
-
-
0.00000000000000000000000000000000000002808
143.0
HSJS3_k127_326501_3
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
9.237e-246
758.0
HSJS3_k127_326501_4
COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
K03466
-
-
2.514e-221
692.0
HSJS3_k127_326501_5
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
K05539
-
-
4.487e-217
675.0
HSJS3_k127_326501_6
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
K11391
-
2.1.1.174
5.929e-211
657.0
HSJS3_k127_326501_7
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1160.0
HSJS3_k127_338022_13
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1154.0
HSJS3_k127_338022_14
Protein of unknown function (DUF1329)
-
-
-
3.882e-311
952.0
HSJS3_k127_338022_15
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
3.607e-297
916.0
HSJS3_k127_338022_16
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.918e-293
970.0
HSJS3_k127_338022_18
Deoxyguanosinetriphosphate triphosphohydrolase-like protein
K01129
-
3.1.5.1
3.065e-293
900.0
HSJS3_k127_338022_19
Transporter associated domain
-
-
-
3.244e-270
834.0
HSJS3_k127_338022_2
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Diadenosine tetraphosphatase and related serine threonine protein
-
-
-
7.328e-218
675.0
HSJS3_k127_338022_27
COG4235, Cytochrome c biogenesis factor
K02200
-
-
2.967e-215
673.0
HSJS3_k127_338022_28
TIGRFAM conserved repeat domain
-
-
-
2.288e-214
668.0
HSJS3_k127_338022_29
transcriptional regulator
-
-
-
1.981e-213
663.0
HSJS3_k127_338022_3
aminopeptidase N
K01256
-
3.4.11.2
0.0
1709.0
HSJS3_k127_338022_30
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
1.073e-212
662.0
HSJS3_k127_338022_31
hydrolase of the alpha beta-hydrolase fold
K07019
-
-
9.295e-208
647.0
HSJS3_k127_338022_32
Taurine catabolism dioxygenase TauD, TfdA family
-
-
-
1.414e-200
627.0
HSJS3_k127_338022_33
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06191
-
-
0.000000000000000000000000000000000000000008264
154.0
HSJS3_k127_338022_77
membrane protein (homolog of Drosophila rhomboid)
-
-
-
0.0000000000000000000000000003247
121.0
HSJS3_k127_338022_78
Domain of unknown function (DUF1853)
K09977
-
-
0.00000000000000000000000004887
119.0
HSJS3_k127_338022_79
Redoxin
-
-
-
0.00000000000000000000952
99.0
HSJS3_k127_338022_8
exporters of the RND superfamily
K07003
-
-
0.0
1378.0
HSJS3_k127_338022_80
-
-
-
-
0.00000000000000000004186
90.0
HSJS3_k127_338022_81
protein conserved in bacteria
K09916
-
-
0.0000000000000005364
80.0
HSJS3_k127_338022_82
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01895
-
6.2.1.1
0.0
1345.0
HSJS3_k127_34109_0
-
-
-
-
0.000000000000000000000000000000000005926
138.0
HSJS3_k127_34109_2
-
-
-
-
0.0000000000000003099
79.0
HSJS3_k127_3419070_0
GTP-binding protein TypA
K06207
-
-
0.0
1205.0
HSJS3_k127_3419070_1
highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues
K01915
-
6.3.1.2
5.601e-316
968.0
HSJS3_k127_3419070_11
COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K03185
-
-
0.00000000000000000000000002799
108.0
HSJS3_k127_3419070_13
Malate dehydrogenase
K00027,K00029
-
1.1.1.38,1.1.1.40
0.0000000000001245
70.0
HSJS3_k127_3419070_2
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
2.669e-291
895.0
HSJS3_k127_3419070_3
COG2267 Lysophospholipase
K01048
-
3.1.1.5
3.036e-194
607.0
HSJS3_k127_3419070_4
Bacterial extracellular solute-binding proteins, family 3
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
1.607e-272
841.0
HSJS3_k127_3789316_3
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
K00557
-
2.1.1.35
3.68e-242
750.0
HSJS3_k127_3789316_4
TRAP-type C4-dicarboxylate transport system periplasmic component
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
0.0
1902.0
HSJS3_k127_4078301_1
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1346.0
HSJS3_k127_4078301_10
Sh3 type 3 domain protein
-
-
-
7.786e-227
707.0
HSJS3_k127_4078301_11
Uncharacterized protein conserved in bacteria (DUF2236)
Catalyzes the ATP-dependent carboxylation of a covalently attached biotin and the transfer of the carboxyl group to pyruvate forming oxaloacetate
K01959
-
6.4.1.1
1.019e-316
971.0
HSJS3_k127_4078301_8
Cytosol aminopeptidase family, catalytic domain
K01255
-
3.4.11.1
1.566e-303
930.0
HSJS3_k127_4078301_9
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
2.954e-263
815.0
HSJS3_k127_4085852_0
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1952.0
HSJS3_k127_4085852_1
7TMR-DISM extracellular 2
K20972
-
-
0.0
1439.0
HSJS3_k127_4085852_10
COG0464 ATPases of the AAA class
-
-
-
1.925e-312
958.0
HSJS3_k127_4085852_11
Belongs to the GARS family
K01945
-
6.3.4.13
6.158e-275
846.0
HSJS3_k127_4085852_12
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
K02667
-
-
1.663e-265
821.0
HSJS3_k127_4085852_13
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
7.359e-257
792.0
HSJS3_k127_4085852_14
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
4.469e-252
780.0
HSJS3_k127_4085852_15
Glycosyltransferase Family 4
-
-
-
3.265e-244
756.0
HSJS3_k127_4085852_16
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
8.399e-240
743.0
HSJS3_k127_4085852_17
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
1.59e-237
735.0
HSJS3_k127_4085852_18
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
6.062e-236
730.0
HSJS3_k127_4085852_19
Glycosyltransferase Family 4
-
-
-
2.15e-231
719.0
HSJS3_k127_4085852_2
Diguanylate cyclase
-
-
-
0.0
1282.0
HSJS3_k127_4085852_20
Peptidoglycan polymerase that is essential for cell wall elongation
K05837
-
-
1.369e-227
707.0
HSJS3_k127_4085852_21
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K03644
-
2.8.1.8
5.037e-213
662.0
HSJS3_k127_4085852_25
response regulator
-
-
-
4.168e-209
653.0
HSJS3_k127_4085852_26
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
5.899e-208
647.0
HSJS3_k127_4085852_27
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
3.983e-207
646.0
HSJS3_k127_4085852_28
diguanylate cyclase activity
K18967,K20971
-
2.7.7.65
1.14e-205
641.0
HSJS3_k127_4085852_29
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K03527
-
1.17.7.4
4.49e-203
633.0
HSJS3_k127_4085852_3
Catalyzes cross-linking of the peptidoglycan cell wall
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01950
-
6.3.5.1
0.0
1038.0
HSJS3_k127_4085852_81
Protein of unknown function (DUF465)
K09794
-
-
0.00000000000000000000000000000000000000005672
152.0
HSJS3_k127_4085852_82
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K00969
-
2.7.7.18
0.0000000000000000000000000000000000000001316
158.0
HSJS3_k127_4085852_84
type IV pilus modification protein PilV
K02671
-
-
0.0000000000000000000000000000000000007427
146.0
HSJS3_k127_4085852_86
Paraquat-inducible protein A
-
-
-
0.000000000000000000000001654
102.0
HSJS3_k127_4085852_87
Type IV minor pilin ComP, DNA uptake sequence receptor
K02655
-
-
0.000000000000000000000001736
108.0
HSJS3_k127_4085852_89
COG4970 Tfp pilus assembly protein FimT
K08084
-
-
0.0000000000001392
78.0
HSJS3_k127_4085852_9
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.297e-319
981.0
HSJS3_k127_4085852_90
Type II transport protein GspH
K08084
-
-
0.000000000003965
72.0
HSJS3_k127_4085852_91
N-methylhydantoinase A acetone carboxylase, beta subunit
K01469,K01473
-
3.5.2.14,3.5.2.9
0.000000003101
57.0
HSJS3_k127_4085852_93
Type IV Pilus-assembly protein W
K02672
-
-
0.00002238
55.0
HSJS3_k127_4085852_94
Pilus assembly protein PilX
K02673
-
-
0.0001347
51.0
HSJS3_k127_4105502_0
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
0.0
1293.0
HSJS3_k127_4108335_0
Diguanylate cyclase
-
-
-
0.0
2830.0
HSJS3_k127_4108335_1
ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
0.0000000000003085
70.0
HSJS3_k127_4108335_2
TonB dependent receptor
K02014
-
-
0.0
1241.0
HSJS3_k127_4108335_3
COG0501 Zn-dependent protease with chaperone function
-
-
-
0.0
1058.0
HSJS3_k127_4108335_4
Belongs to the ompA family
K03286
-
-
5.56e-200
629.0
HSJS3_k127_4108335_5
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0
1056.0
HSJS3_k127_4114272_1
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
2.637e-294
904.0
HSJS3_k127_4114272_2
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
ATPase components of ABC transporters with duplicated ATPase domains
-
-
-
0.0
1069.0
HSJS3_k127_4200630_4
Alpha amylase, catalytic domain
K00690
-
2.4.1.7
4.595e-321
983.0
HSJS3_k127_4200630_5
malate quinone oxidoreductase
K00116
-
1.1.5.4
1.101e-315
968.0
HSJS3_k127_4200630_6
Na H antiporter NhaD and related arsenite
-
-
-
2.507e-237
737.0
HSJS3_k127_4200630_7
Major facilitator superfamily
-
-
-
1.97e-234
730.0
HSJS3_k127_4200630_8
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
1.722e-224
702.0
HSJS3_k127_4200630_9
protein conserved in bacteria
K00243
-
-
1.785e-223
698.0
HSJS3_k127_4208380_0
Outer membrane protein beta-barrel family
-
-
-
0.0
1734.0
HSJS3_k127_4208380_1
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts
-
-
-
0.0000000004914
62.0
HSJS3_k127_4375563_4
-
-
-
-
0.00000003507
56.0
HSJS3_k127_4375563_5
-
-
-
-
0.0000002859
51.0
HSJS3_k127_4385163_0
cytochrome C peroxidase
-
-
-
0.0
1362.0
HSJS3_k127_4385163_1
alkaline phosphatase
-
-
-
0.0
1154.0
HSJS3_k127_4385163_10
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K00604
-
2.1.2.9
9.313e-194
605.0
HSJS3_k127_4385163_11
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Belongs to the phosphatidylserine decarboxylase family
K01613
-
4.1.1.65
1.138e-301
928.0
HSJS3_k127_4385163_3
found to be peripherally associated with the inner membrane in Escherichia coli
K03499
-
-
1.113e-283
873.0
HSJS3_k127_4385163_4
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K03500
-
2.1.1.176
3.332e-268
828.0
HSJS3_k127_4385163_5
Cytochrome P450
-
-
-
5.075e-265
819.0
HSJS3_k127_4385163_6
Rossmann fold nucleotide-binding protein involved in DNA uptake
K04096
-
-
3.429e-242
751.0
HSJS3_k127_4385163_7
Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
K03406
-
-
9.195e-225
702.0
HSJS3_k127_4385163_8
protein containing LysM domain
-
-
-
2.165e-222
690.0
HSJS3_k127_4385163_9
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.828e-273
843.0
HSJS3_k127_4480245_60
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
2.045e-255
790.0
HSJS3_k127_4480245_9
Sulfatase-modifying factor enzyme 1
-
-
-
3.745e-255
788.0
HSJS3_k127_449470_0
membrane
-
-
-
0.0
2556.0
HSJS3_k127_449470_1
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Involved in the processing of the 5'end of 16S rRNA
K08301
-
-
5.335e-305
936.0
HSJS3_k127_449470_30
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K09774
-
-
0.00000000000000000000003166
106.0
HSJS3_k127_449470_4
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
2.913e-274
844.0
HSJS3_k127_449470_5
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.351e-270
834.0
HSJS3_k127_449470_6
Acts as a magnesium transporter
K06213
-
-
2.16e-270
835.0
HSJS3_k127_449470_7
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.0000000000000000000005437
96.0
HSJS3_k127_4641672_12
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K03525
-
2.7.1.33
0.000000000000000002321
94.0
HSJS3_k127_4641672_2
TonB dependent receptor
K02014
-
-
0.0
1320.0
HSJS3_k127_4641672_3
COG1283 Na phosphate symporter
K03324
-
-
0.0
1080.0
HSJS3_k127_4641672_4
PFAM Ion transport 2
K10716
-
-
2.694e-237
736.0
HSJS3_k127_4641672_5
belongs to the carbohydrate kinase PfkB family
K00847,K00892
-
2.7.1.4,2.7.1.73
1.042e-206
644.0
HSJS3_k127_4641672_6
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K03524
-
6.3.4.15
5.959e-204
636.0
HSJS3_k127_4641672_7
ABC-type amino acid transport signal transduction systems periplasmic component domain
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0
1103.0
HSJS3_k127_4830172_2
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
0.0
1014.0
HSJS3_k127_4830172_3
Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
K14267
-
2.6.1.17
2.127e-265
817.0
HSJS3_k127_4830172_4
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00627
-
2.3.1.12
0.0000000000000000000000000000000000000000001954
159.0
HSJS3_k127_495609_0
Carbamoyl-phosphate synthetase ammonia chain
K01955
-
6.3.5.5
0.0
2137.0
HSJS3_k127_495609_1
Heat shock 70 kDa protein
K04043
-
-
0.0
1213.0
HSJS3_k127_495609_10
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
May be involved in recombinational repair of damaged DNA
K03631
-
-
0.0
1052.0
HSJS3_k127_495609_20
-
-
-
-
0.0000000000000000000000004843
113.0
HSJS3_k127_495609_3
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
K03308
-
-
4.115e-304
935.0
HSJS3_k127_495609_4
carbamoyl-phosphate synthetase glutamine chain
K01956
-
6.3.5.5
3.192e-252
778.0
HSJS3_k127_495609_5
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
1.432e-250
774.0
HSJS3_k127_495609_6
Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1690.0
HSJS3_k127_515479_1
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00210,K00800
-
1.3.1.12,2.5.1.19
0.0
1440.0
HSJS3_k127_515479_10
G-rich domain on putative tyrosine kinase
K05789
-
-
7.44e-238
736.0
HSJS3_k127_515479_11
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
1.894e-237
735.0
HSJS3_k127_515479_12
COG0477 Permeases of the major facilitator superfamily
K05820
-
-
2.954e-235
731.0
HSJS3_k127_515479_13
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.033e-234
727.0
HSJS3_k127_515479_14
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K00831
-
2.6.1.52
7.506e-234
724.0
HSJS3_k127_515479_15
Prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
1.95e-233
724.0
HSJS3_k127_515479_16
Tryptophanyl-tRNA synthetase
K01867
-
6.1.1.2
7.646e-216
671.0
HSJS3_k127_515479_17
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue
K07320
-
2.1.1.298
1.464e-207
645.0
HSJS3_k127_515479_18
esterase of the alpha-beta hydrolase superfamily
K07001
-
-
2.728e-201
627.0
HSJS3_k127_515479_19
diguanylate cyclase
-
-
-
9.757e-194
605.0
HSJS3_k127_515479_2
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
K02945
-
-
0.0
1107.0
HSJS3_k127_515479_6
Protein of unknown function (DUF3422)
-
-
-
1.401e-290
893.0
HSJS3_k127_515479_7
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
2.266e-277
854.0
HSJS3_k127_515479_8
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
3.054e-265
817.0
HSJS3_k127_515479_9
membrane
K07058
-
-
5.39e-242
751.0
HSJS3_k127_516569_0
RHS Repeat
-
-
-
0.0
2097.0
HSJS3_k127_5269333_0
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
K05592
-
3.6.4.13
0.0
1126.0
HSJS3_k127_5349859_0
Fatty acid desaturase
-
-
-
4.41e-238
741.0
HSJS3_k127_5349859_1
Methylenetetrahydrofolate reductase
-
-
-
1.539e-204
637.0
HSJS3_k127_5349859_2
Arabinose-binding domain of AraC transcription regulator, N-term
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
1830.0
HSJS3_k127_53542_10
Belongs to the beta-ketoacyl-ACP synthases family
K18473
-
2.3.1.180
0.0
1033.0
HSJS3_k127_53542_11
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
0.0
996.0
HSJS3_k127_53542_12
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
5e-324
998.0
HSJS3_k127_53542_13
COG0659 Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
5.879e-319
981.0
HSJS3_k127_53542_14
COG0348 Polyferredoxin
-
-
-
4.506e-316
967.0
HSJS3_k127_53542_15
ABC-type phosphate transport system, periplasmic component
K02040
-
-
3.334e-293
902.0
HSJS3_k127_53542_16
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
1.255e-292
899.0
HSJS3_k127_53542_17
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
1.289e-292
900.0
HSJS3_k127_53542_18
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
3.175e-285
877.0
HSJS3_k127_53542_19
HipA N-terminal domain
K07154
-
2.7.11.1
2.721e-262
810.0
HSJS3_k127_53542_2
P-type ATPase
K01533
-
3.6.3.4
0.0
1454.0
HSJS3_k127_53542_20
protein conserved in bacteria
K09919
-
-
9.874e-239
739.0
HSJS3_k127_53542_21
FR47-like protein
-
-
-
1.572e-237
735.0
HSJS3_k127_53542_22
fatty acid desaturase
K00508
-
1.14.19.3
1.285e-231
719.0
HSJS3_k127_53542_23
polysaccharide deacetylase
-
-
-
8.78e-214
666.0
HSJS3_k127_53542_24
AraC family transcriptional regulator
-
-
-
3.157e-211
658.0
HSJS3_k127_53542_25
diguanylate cyclase activity
-
-
-
1.017e-206
647.0
HSJS3_k127_53542_26
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.0
1202.0
HSJS3_k127_53542_60
COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
1.64e-244
759.0
HSJS3_k127_5409391_1
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K03581
-
3.1.11.5
0.00000000000000000000000000000001558
130.0
HSJS3_k127_5411830_2
-
-
-
-
0.00000000000000000000000000000004087
131.0
HSJS3_k127_5418841_0
Reverse transcriptase (RNA-dependent DNA polymerase)
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
K01869
-
6.1.1.4
0.0
1592.0
HSJS3_k127_549122_10
Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.00000000000000000000000000000000000001163
144.0
HSJS3_k127_549122_25
Belongs to the N-Me-Phe pilin family
K02650,K02655
-
-
0.000000000000000002903
91.0
HSJS3_k127_549122_3
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1066.0
HSJS3_k127_549122_4
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
9.717e-309
949.0
HSJS3_k127_549122_5
alanine symporter
K03310
-
-
2.833e-281
866.0
HSJS3_k127_549122_6
type II secretion system protein
K02653
-
-
4.553e-239
742.0
HSJS3_k127_549122_7
GGDEF domain
-
-
-
5.297e-237
735.0
HSJS3_k127_549122_8
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases
K01908
-
6.2.1.17
0.0
1293.0
HSJS3_k127_5512155_1
Domain of unknown function (DUF3364)
K02591
-
1.18.6.1
4.676e-315
969.0
HSJS3_k127_5512155_10
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
4.254e-215
672.0
HSJS3_k127_5512155_11
Universal stress protein family
K14055
-
-
5.066e-197
615.0
HSJS3_k127_5512155_12
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Belongs to the glutaredoxin family. Monothiol subfamily
K07390
-
-
0.0000000000000000000000000000000000003211
142.0
HSJS3_k127_5512155_54
Ferredoxin
-
-
-
0.0000000000000000000000000000000000005553
142.0
HSJS3_k127_5512155_55
4Fe-4S binding domain
-
-
-
0.000000000000000000000000000000000001838
139.0
HSJS3_k127_5512155_56
Protein of unknown function (DUF1289)
-
-
-
0.00000000000000000000000000000003561
126.0
HSJS3_k127_5512155_57
Transposase
K07483
-
-
0.000000000000000000000000000006821
119.0
HSJS3_k127_5512155_58
Nif11 domain
-
-
-
0.000000000000000000000000188
106.0
HSJS3_k127_5512155_59
NifT/FixU protein
K02593
-
-
0.000000000000000000005701
93.0
HSJS3_k127_5512155_6
Dinitrogenase iron-molybdenum cofactor
K02585
-
-
1.245e-270
839.0
HSJS3_k127_5512155_60
RnfH family Ubiquitin
K09801
-
-
0.000000000000000001737
89.0
HSJS3_k127_5512155_61
Rop-like
-
-
-
0.000000000000000006624
85.0
HSJS3_k127_5512155_62
-
-
-
-
0.000000000000000009535
85.0
HSJS3_k127_5512155_63
Belongs to the BolA IbaG family
-
-
-
0.00000000000000001309
85.0
HSJS3_k127_5512155_64
-
-
-
-
0.0000000000000002168
81.0
HSJS3_k127_5512155_65
-
-
-
-
0.0000000000000003163
84.0
HSJS3_k127_5512155_66
NifZ domain
K02597
-
-
0.0000000002422
65.0
HSJS3_k127_5512155_67
transposase activity
K07483
-
-
0.0000001962
52.0
HSJS3_k127_5512155_69
Pyridoxamine 5'-phosphate oxidase
K07006,K22343,K22444
-
1.14.13.238,1.14.13.239
0.0009163
43.0
HSJS3_k127_5512155_7
peptidase M20
K01436
-
-
3.543e-258
796.0
HSJS3_k127_5512155_8
COG0006 Xaa-Pro aminopeptidase
K01271
-
3.4.13.9
1.761e-232
727.0
HSJS3_k127_5512155_9
transcriptional regulator
K02584
-
-
9.767e-221
696.0
HSJS3_k127_5514590_0
methyl-accepting chemotaxis protein
-
-
-
2.25e-304
938.0
HSJS3_k127_5514590_1
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K02302,K02303
-
1.3.1.76,2.1.1.107,4.99.1.4
1.026e-278
859.0
HSJS3_k127_5514590_2
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Belongs to the binding-protein-dependent transport system permease family
K02057
-
-
2.128e-224
696.0
HSJS3_k127_5551085_9
Dehydrogenase
K12957,K13979
-
-
8.473e-222
687.0
HSJS3_k127_5560379_0
Thrombospondin type 3 repeat
-
-
-
0.0
1016.0
HSJS3_k127_5560379_1
COG0457 FOG TPR repeat
-
-
-
0.00000000002146
64.0
HSJS3_k127_5585877_0
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1089.0
HSJS3_k127_5585877_1
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
2.711e-274
844.0
HSJS3_k127_5585877_10
COG1943 Transposase and inactivated derivatives
-
-
-
0.0000000000000000001109
88.0
HSJS3_k127_5585877_2
-
-
-
-
8.576e-252
778.0
HSJS3_k127_5585877_3
Belongs to the peptidase S1C family
K04691,K04771,K04772
-
3.4.21.107
3.751e-241
749.0
HSJS3_k127_5585877_4
COG0697 Permeases of the drug metabolite transporter (DMT) superfamily
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
0.0
1147.0
HSJS3_k127_5654685_3
Protein of unknown function (DUF1501)
-
-
-
5.529e-285
877.0
HSJS3_k127_5654685_4
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
1.234e-266
820.0
HSJS3_k127_5654685_5
TRAP-type C4-dicarboxylate transport system periplasmic component
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1418.0
HSJS3_k127_5686371_1
Subunit R is required for both nuclease and ATPase activities, but not for modification
K01153
-
3.1.21.3
0.0
1127.0
HSJS3_k127_5686371_2
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.0000000000000000000000000000000000001509
141.0
HSJS3_k127_569690_28
ATP synthase
K02116
-
-
0.0000000000000000000000001553
109.0
HSJS3_k127_569690_3
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
9.319e-300
920.0
HSJS3_k127_569690_4
COG0477 Permeases of the major facilitator superfamily
-
-
-
3.466e-249
769.0
HSJS3_k127_569690_5
Putative amidoligase enzyme (DUF2126)
-
-
-
2.035e-247
764.0
HSJS3_k127_569690_6
Histidine kinase-like ATPases
-
-
-
2.739e-235
733.0
HSJS3_k127_569690_7
A predicted alpha-helical domain with a conserved ER motif.
-
-
-
1.518e-200
625.0
HSJS3_k127_569690_8
it plays a direct role in the translocation of protons across the membrane
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.0
1566.0
HSJS3_k127_5741067_1
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1367.0
HSJS3_k127_5741067_10
GHMP kinases C terminal
K07031
-
2.7.1.168
1.727e-234
725.0
HSJS3_k127_5741067_11
Tetratricopeptide repeat
-
-
-
7.601e-234
728.0
HSJS3_k127_5741067_12
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K06917
-
-
1.456e-226
703.0
HSJS3_k127_5741067_13
Barrel-sandwich domain of CusB or HlyD membrane-fusion
-
-
-
2.504e-221
688.0
HSJS3_k127_5741067_14
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
2.653e-220
684.0
HSJS3_k127_5741067_15
beta-galactosidase activity
-
-
-
6.432e-216
675.0
HSJS3_k127_5741067_16
Beta-galactosidase
-
-
-
8.728e-210
657.0
HSJS3_k127_5741067_17
Arabinose-binding domain of AraC transcription regulator, N-term
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.00000000000000000000000000000003681
125.0
HSJS3_k127_5741067_39
-
-
-
-
0.0000001246
53.0
HSJS3_k127_5741067_4
COG3639 ABC-type phosphate phosphonate transport system, permease component
K02042
-
-
1.741e-307
945.0
HSJS3_k127_5741067_5
AMP-binding enzyme C-terminal domain
K01897
-
6.2.1.3
1.157e-296
912.0
HSJS3_k127_5741067_6
Outer membrane efflux protein
-
-
-
1.333e-284
878.0
HSJS3_k127_5741067_7
Alkaline phosphatase
K01113
-
3.1.3.1
2.35e-274
846.0
HSJS3_k127_5741067_8
polysaccharide biosynthetic process
-
-
-
2.446e-271
839.0
HSJS3_k127_5741067_9
Glycosyltransferase Family 4
-
-
-
2.448e-261
807.0
HSJS3_k127_5792938_0
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
1.865e-313
961.0
HSJS3_k127_5792938_1
Belongs to the ompA family
K03286,K20276
-
-
6.039e-233
722.0
HSJS3_k127_5792938_2
COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain
Polyketide cyclase / dehydrase and lipid transport
-
-
-
0.00000000273
65.0
HSJS3_k127_5842096_0
Histidine kinase
-
-
-
0.0
1925.0
HSJS3_k127_5842096_1
Belongs to the GPI family
K01810
-
5.3.1.9
0.0
1137.0
HSJS3_k127_5842096_10
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
1.276e-288
887.0
HSJS3_k127_5842096_3
regulator
-
-
-
2.251e-285
878.0
HSJS3_k127_5842096_4
Aminotransferase
-
-
-
8.455e-240
747.0
HSJS3_k127_5842096_5
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K08963
-
5.3.1.23
1.505e-209
653.0
HSJS3_k127_5842096_6
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K03580
-
-
0.0
1277.0
HSJS3_k127_6161502_0
Flagellar hook protein flgE
K02390
-
-
0.0
2267.0
HSJS3_k127_6161502_1
Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K02394
-
-
1.158e-222
693.0
HSJS3_k127_6161502_10
Belongs to the flagella basal body rod proteins family
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates
K01426
-
3.5.1.4
0.000000000000001371
76.0
HSJS3_k127_6328693_0
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1147.0
HSJS3_k127_6328693_1
TRAP-type C4-dicarboxylate transport system periplasmic component
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0
1189.0
HSJS3_k127_6827369_1
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
Type IX secretion system membrane protein PorP/SprF
-
-
-
3.044e-312
961.0
HSJS3_k127_6827369_3
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
K00974
-
2.7.7.72
3.634e-263
813.0
HSJS3_k127_6827369_4
Flagellar assembly protein T, middle domain
-
-
-
7.725e-240
743.0
HSJS3_k127_6827369_5
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K01409
-
2.3.1.234
2.606e-225
698.0
HSJS3_k127_6827369_6
of the drug metabolite transporter (DMT) superfamily
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1765.0
HSJS3_k127_7008977_1
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
0.0
1693.0
HSJS3_k127_7008977_10
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
-
-
-
2.436e-233
723.0
HSJS3_k127_7008977_11
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
9.735e-232
721.0
HSJS3_k127_7008977_12
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K01488,K21053
-
3.5.4.2,3.5.4.4
1.205e-228
708.0
HSJS3_k127_7008977_13
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
3.791e-225
700.0
HSJS3_k127_7008977_14
ABC transporter substrate-binding protein PnrA-like
K02058
-
-
1.111e-224
698.0
HSJS3_k127_7008977_15
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.0000000000000000000000000000000000000000001419
159.0
HSJS3_k127_7017748_31
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K00989
-
2.7.7.56
0.00000000000000000000000000000000000003734
143.0
HSJS3_k127_7017748_32
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.00000000000000000000000000000000002832
135.0
HSJS3_k127_7017748_33
there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
K02913
-
-
0.00000000000000000000000007928
107.0
HSJS3_k127_7017748_34
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
0.0000000000000003869
78.0
HSJS3_k127_7017748_4
belongs to the aldehyde dehydrogenase family
K00154
-
1.2.1.68
3.146e-312
957.0
HSJS3_k127_7017748_5
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
1.388e-245
762.0
HSJS3_k127_7017748_6
Protein of unknown function (DUF3080)
-
-
-
5.765e-213
663.0
HSJS3_k127_7017748_7
Belongs to the acetylglutamate kinase family. ArgB subfamily
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
0.00000000000000000000005733
97.0
HSJS3_k127_7075259_0
AcrB/AcrD/AcrF family
-
-
-
0.0
2000.0
HSJS3_k127_7075259_1
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
1.497e-246
762.0
HSJS3_k127_7075259_7
Outer membrane efflux protein
-
-
-
3.222e-234
732.0
HSJS3_k127_7075259_8
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0
2799.0
HSJS3_k127_7301929_1
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0
2693.0
HSJS3_k127_7301929_10
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.0000000000000000000003284
95.0
HSJS3_k127_7301929_14
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000001845
72.0
HSJS3_k127_7301929_2
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
2e-323
990.0
HSJS3_k127_7384329_5
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K01012
-
2.8.1.6
2.368e-225
700.0
HSJS3_k127_7384329_6
Major Facilitator Superfamily
-
-
-
9.094e-221
688.0
HSJS3_k127_7384329_7
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
-
-
-
2.141e-219
680.0
HSJS3_k127_7384329_8
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K00766
-
2.4.2.18
1.098e-209
653.0
HSJS3_k127_7384329_9
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
COG2230 Cyclopropane fatty acid synthase and related methyltransferases
K00574
-
2.1.1.79
0.0000000000000000000000002303
105.0
HSJS3_k127_8059623_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1755.0
HSJS3_k127_8059623_1
COG0457 FOG TPR repeat
-
-
-
0.0
1079.0
HSJS3_k127_8059623_10
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
3.885e-255
788.0
HSJS3_k127_8059623_11
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
8.062e-245
758.0
HSJS3_k127_8059623_12
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
5.048e-244
755.0
HSJS3_k127_8059623_13
Major facilitator superfamily
K07552
-
-
2.803e-243
753.0
HSJS3_k127_8059623_14
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
3.616e-235
728.0
HSJS3_k127_8059623_15
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
1.136e-231
717.0
HSJS3_k127_8059623_16
Phosphate starvation-inducible protein PhoH
K06217
-
-
2.002e-223
693.0
HSJS3_k127_8059623_17
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
1.59e-221
688.0
HSJS3_k127_8059623_18
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
K03438
-
2.1.1.199
1.304e-196
614.0
HSJS3_k127_8059623_19
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K00948
-
2.7.6.1
3.504e-195
610.0
HSJS3_k127_8059623_2
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum
K03587
-
3.4.16.4
0.0
1074.0
HSJS3_k127_8059623_20
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K03589
-
-
0.00000000000000000004791
100.0
HSJS3_k127_8059623_45
Pyridine nucleotide-disulphide oxidoreductase
K17218
-
1.8.5.4
0.0000000000005832
68.0
HSJS3_k127_8059623_46
Peptidase family M48
-
-
-
0.000000001159
59.0
HSJS3_k127_8059623_5
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
1.727e-291
896.0
HSJS3_k127_8059623_6
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
1.612e-290
895.0
HSJS3_k127_8059623_7
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
5.714e-263
813.0
HSJS3_k127_8059623_8
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
9.134e-263
811.0
HSJS3_k127_8059623_9
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
5.841e-256
792.0
HSJS3_k127_8119192_0
Involved in the tonB-independent uptake of proteins
glyoxalase bleomycin resistance protein dioxygenase
-
-
-
0.000000000000000000000000002961
111.0
HSJS3_k127_8214219_0
Belongs to the peptidase M16 family
K06972
-
-
0.0
1936.0
HSJS3_k127_8214219_1
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1596.0
HSJS3_k127_8214219_10
GGDEF domain
-
-
-
3.277e-211
661.0
HSJS3_k127_8214219_11
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
2.043e-209
652.0
HSJS3_k127_8214219_12
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.000000000000000000000000000000000000007533
145.0
HSJS3_k127_8214219_28
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000000000009524
124.0
HSJS3_k127_8214219_29
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K20455
-
4.2.1.117
0.00000000000000001298
81.0
HSJS3_k127_8214219_3
Protein of unknown function (DUF1552)
-
-
-
7.004e-284
873.0
HSJS3_k127_8214219_30
Parallel beta-helix repeats
-
-
-
0.000000000004409
79.0
HSJS3_k127_8214219_4
MotA TolQ ExbB proton channel
K03561
-
-
9.917e-272
840.0
HSJS3_k127_8214219_5
protein conserved in bacteria
K09788
-
-
1.74e-246
762.0
HSJS3_k127_8214219_6
COG0520 Selenocysteine lyase
-
-
-
1.804e-246
762.0
HSJS3_k127_8214219_7
Ankyrin repeat
-
-
-
1.509e-244
760.0
HSJS3_k127_8214219_8
DNA polymerase III subunit delta
K02341
-
2.7.7.7
7.574e-223
691.0
HSJS3_k127_8214219_9
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
1.692e-214
669.0
HSJS3_k127_8227311_0
Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
K01835
-
5.4.2.2
9.62e-315
965.0
HSJS3_k127_8227311_1
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K03580
-
-
0.0000000000000002528
78.0
HSJS3_k127_8235174_0
Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95 C
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Phosphate ABC transporter substrate-binding protein
K02040
-
-
1.415e-216
674.0
HSJS3_k127_8275732_7
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03110
-
-
6.57e-213
667.0
HSJS3_k127_8275732_8
Part of the ABC transporter FtsEX involved in cellular division
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K02837
-
-
0.0
1079.0
HSJS3_k127_8453310_1
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
3.679e-277
852.0
HSJS3_k127_8453310_10
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.000000001752
59.0
HSJS3_k127_8599240_0
Methionine synthase
K00548
-
2.1.1.13
0.0
2456.0
HSJS3_k127_8599240_1
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1527.0
HSJS3_k127_8599240_10
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K03314
-
-
7.046e-304
934.0
HSJS3_k127_8599240_7
Na -driven multidrug efflux pump
-
-
-
9.106e-281
865.0
HSJS3_k127_8599240_8
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
2.34e-276
851.0
HSJS3_k127_8599240_9
ABC-type oligopeptide transport system, periplasmic component
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
ATPase family associated with various cellular activities (AAA)
-
-
-
0.00000000000000000000000001781
125.0
HSJS3_k127_9163_14
Belongs to the GMC oxidoreductase family
K00108
-
1.1.99.1
0.000000000000000000000000277
123.0
HSJS3_k127_9163_15
SNF2 family N-terminal domain
-
-
-
0.0000000000000000000000004968
123.0
HSJS3_k127_9163_16
interleukin-8 biosynthetic process
-
-
-
0.000000000000000000000000956
118.0
HSJS3_k127_9163_17
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
K03581
-
3.1.11.5
0.000000000000000000001181
111.0
HSJS3_k127_9163_18
Phage Tail Collar Domain
-
-
-
0.000000000000000000002264
109.0
HSJS3_k127_9163_2
cyclin-dependent protein serine/threonine kinase activity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
K14165
-
3.1.3.16,3.1.3.48
0.000000000000000003153
91.0
HSJS3_k127_9163_24
-
-
-
-
0.000000000000000004324
99.0
HSJS3_k127_9163_26
Beta-lactamase
-
-
-
0.00000000000000003202
96.0
HSJS3_k127_9163_27
spectrin binding
-
-
-
0.0000000000000000455
95.0
HSJS3_k127_9163_28
protein tyrosine/serine/threonine phosphatase activity
K14165,K14819
-
3.1.3.16,3.1.3.48
0.00000000000002649
81.0
HSJS3_k127_9163_29
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.00000000000000000000000000002126
129.0
HSJS3_k127_9315345_19
Type II secretion system protein B
-
-
-
0.00000000002162
73.0
HSJS3_k127_9315345_2
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01638
-
2.3.3.9
0.0
1472.0
HSJS3_k127_9315345_20
-
-
-
-
0.00000000003861
64.0
HSJS3_k127_9315345_3
helicase
K03722
-
3.6.4.12
0.0
1414.0
HSJS3_k127_9315345_4
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
1.921e-292
899.0
HSJS3_k127_9315345_5
Type II secretory pathway, component ExeA
K02450
-
-
4.197e-281
868.0
HSJS3_k127_9315345_6
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
7.764e-268
827.0
HSJS3_k127_9315345_7
Transcription factor
K18850
-
1.14.11.47
4.058e-263
810.0
HSJS3_k127_9315345_8
Polysaccharide biosynthesis protein
K08679
-
5.1.3.6
6.645e-219
679.0
HSJS3_k127_9315345_9
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.336e-208
648.0
HSJS3_k127_9359474_0
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1710.0
HSJS3_k127_9359474_1
Monooxygenase, flavin-binding family
-
-
-
0.0
1091.0
HSJS3_k127_9359474_10
COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
helix_turn_helix, arabinose operon control protein
-
-
-
0.000000000000000000003801
106.0
HSJS3_k127_9359474_22
Predicted metal-dependent hydrolase
K07044
-
-
0.00000000000001291
75.0
HSJS3_k127_9359474_23
-
-
-
-
0.0000000006732
61.0
HSJS3_k127_9359474_24
-
-
-
-
0.000000002783
60.0
HSJS3_k127_9359474_25
-
-
-
-
0.0001754
45.0
HSJS3_k127_9359474_3
Belongs to the aspartokinase family
K00928
-
2.7.2.4
7.486e-259
800.0
HSJS3_k127_9359474_4
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
K00265
-
1.4.1.13,1.4.1.14
0.0
2987.0
HSJS3_k127_9420220_1
NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit
K05559
-
-
0.0
1739.0
HSJS3_k127_9420220_10
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
-
-
-
5.941e-304
935.0
HSJS3_k127_9420220_11
Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit
K05561
-
-
3.105e-298
917.0
HSJS3_k127_9420220_12
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
7.794e-296
908.0
HSJS3_k127_9420220_13
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
5.957e-278
857.0
HSJS3_k127_9420220_14
ATPases associated with a variety of cellular activities
K05776
-
-
9.185e-274
846.0
HSJS3_k127_9420220_15
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
1.307e-259
803.0
HSJS3_k127_9420220_16
PFAM Metal-dependent phosphohydrolase, HD
-
-
-
7.77e-242
751.0
HSJS3_k127_9420220_17
AAA domain
K03112
-
-
5.426e-232
726.0
HSJS3_k127_9420220_18
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
6.18e-232
719.0
HSJS3_k127_9420220_19
Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K01735
-
4.2.3.4
2.004e-227
706.0
HSJS3_k127_9420220_2
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000000000000000000000000002276
142.0
HSJS3_k127_9420220_57
Multiple resistance and pH regulation protein F (MrpF / PhaF)
K05563
-
-
0.0000000000000000000000003725
107.0
HSJS3_k127_9420220_6
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
0.0
1225.0
HSJS3_k127_9420220_7
glutamate synthase
K00266
-
1.4.1.13,1.4.1.14
6.854e-316
967.0
HSJS3_k127_9420220_8
FAD linked oxidase
-
-
-
1.953e-306
940.0
HSJS3_k127_9420220_9
Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
-
-
-
4.838e-305
939.0
HSJS3_k127_9429305_0
2-oxoglutarate dehydrogenase
K00164
-
1.2.4.2
0.0
1929.0
HSJS3_k127_9429305_1
Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
K00658
-
2.3.1.61
5.307e-247
765.0
HSJS3_k127_9429305_6
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
3.264e-240
744.0
HSJS3_k127_9429305_7
signal transduction protein containing EAL and modified HD-GYP domains
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
1.527e-245
758.0
HSJS3_k127_9497757_2
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
9.369e-224
694.0
HSJS3_k127_9497757_3
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
K05541
-
-
6.948e-205
639.0
HSJS3_k127_9585673_11
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K00758
-
2.4.2.4
1.282e-311
959.0
HSJS3_k127_9585673_4
beta-lactamase
K07576
-
-
1.797e-297
913.0
HSJS3_k127_9585673_5
GGDEF domain
-
-
-
8.072e-288
893.0
HSJS3_k127_9585673_6
protein conserved in bacteria
K09760
-
-
3.316e-279
863.0
HSJS3_k127_9585673_7
Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit
K01572
-
4.1.1.3
1.405e-242
751.0
HSJS3_k127_9585673_8
Taurine catabolism dioxygenase TauD, TfdA family
-
-
-
1.242e-230
715.0
HSJS3_k127_9585673_9
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
K15257
-
-
2.322e-222
689.0
HSJS3_k127_9595265_0
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Uncharacterized protein conserved in bacteria (DUF2256)
-
-
-
0.00000000000000000000000000000001333
126.0
HSJS3_k127_9619471_2
Belongs to the UPF0061 (SELO) family
-
-
-
4.223e-316
970.0
HSJS3_k127_9619471_3
Belongs to the glutamate synthase family
-
-
-
8.274e-299
916.0
HSJS3_k127_9619471_4
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K07516
-
1.1.1.35
4.108e-270
832.0
HSJS3_k127_9619471_5
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K01457
-
3.5.1.54
0.0
1154.0
HSJS3_k127_9717977_3
Belongs to the binding-protein-dependent transport system permease family
K11960
-
-
1.908e-310
956.0
HSJS3_k127_9717977_4
branched-chain amino acid
K11959
-
-
5.735e-289
887.0
HSJS3_k127_9717977_5
Belongs to the acetyltransferase family. ArgA subfamily
K14682
-
2.3.1.1
2.938e-277
854.0
HSJS3_k127_9717977_6
Adenylate cyclase
K18446
-
3.6.1.25
2.791e-276
851.0
HSJS3_k127_9717977_7
-
-
-
-
9.376e-272
837.0
HSJS3_k127_9717977_8
Belongs to the peptidase M20A family. ArgE subfamily
K01438
-
3.5.1.16
5.741e-256
789.0
HSJS3_k127_9717977_9
Belongs to the binding-protein-dependent transport system permease family
K11961
-
-
6.07e-246
760.0
HSJS3_k127_9717982_0
COG0457 FOG TPR repeat
-
-
-
3.528e-209
656.0
HSJS3_k127_9739133_0
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K00383
-
1.8.1.7
2.29e-228
708.0
HSJS3_k127_9739133_1
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids
K01897
-
6.2.1.3
0.0
1133.0
HSJS3_k127_9893388_5
Tetratricopeptide repeat
-
-
-
0.0
1127.0
HSJS3_k127_9893388_6
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
0.0
1075.0
HSJS3_k127_9893388_7
Histidine kinase
K10715
-
2.7.13.3
0.0
1034.0
HSJS3_k127_9893388_8
protein conserved in bacteria
K09989
-
-
7.984e-263
809.0
HSJS3_k127_9893388_9
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K03684
-
3.1.13.5
2.66e-250
773.0
HSJS3_k127_9986132_0
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.0
1338.0
HSJS3_k127_9986132_1
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
K03528
-
-
8.267e-240
744.0
HSJS3_k127_9986132_2
Required for chromosome condensation and partitioning
