Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Nucleotidyl transferase AbiEii toxin, Type IV TA system
-
-
-
0.000001079
55.0
LZS1_k127_2893162_0
EcoEI R protein C-terminal
K01153
-
3.1.21.3
0.0
1103.0
LZS1_k127_2893162_1
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
5.968e-253
807.0
LZS1_k127_2893162_10
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
8.006e-203
649.0
LZS1_k127_2893162_20
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K02654
-
3.4.23.43
0.0000000000000000000000000000000000000000000137
171.0
LZS1_k127_2893162_23
Transcriptional regulator
-
-
-
0.00000000000000000000000000000000000000000006464
166.0
LZS1_k127_2893162_24
endonuclease III
K01247
-
3.2.2.21
0.000000000000000000000000000000000000005192
153.0
LZS1_k127_2893162_25
Transposase
K07491
-
-
0.00000000000000000000000000000000000005198
151.0
LZS1_k127_2893162_26
COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
-
-
-
0.000000000000000000000000000000002998
134.0
LZS1_k127_2893162_27
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K02520
-
-
0.00000000000000000000000000000002176
132.0
LZS1_k127_2893162_28
PFAM ErfK YbiS YcfS YnhG family protein
-
-
-
0.00000000000000000000000000001521
126.0
LZS1_k127_2893162_29
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K02887
-
-
0.000000000000000000000000662
108.0
LZS1_k127_2893162_3
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Belongs to the bacterial ribosomal protein bL32 family
K02911
GO:0003674,GO:0003735,GO:0005198
-
0.000000003017
59.0
LZS1_k127_2893162_38
Pfam:N_methyl_2
K02456
-
-
0.000000005757
63.0
LZS1_k127_2893162_39
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.00000001026
57.0
LZS1_k127_3141861_8
Methyltransferase activity. It is involved in the biological process described with metabolic process
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
K02838
-
-
0.0000000000000000000000000000000000006585
145.0
LZS1_k127_3337342_21
Glycosyl transferase, WecB TagA CpsF family
K05946
-
2.4.1.187
0.0000000000000000000000000000000004668
140.0
LZS1_k127_3337342_22
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
K02935
-
-
0.0000000000000000000000000000001022
128.0
LZS1_k127_3337342_23
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K01491
-
1.5.1.5,3.5.4.9
0.0000000000000000000000000324
117.0
LZS1_k127_3337342_26
-
-
-
-
0.000000000000000000000000493
111.0
LZS1_k127_3337342_27
Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
K02863
-
-
0.000000000000000000000003441
113.0
LZS1_k127_3337342_28
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.000002831
53.0
LZS1_k127_3337342_43
Helix-turn-helix XRE-family like proteins
-
-
-
0.00004694
49.0
LZS1_k127_3337342_44
WD40 repeats
-
-
-
0.00006856
55.0
LZS1_k127_3337342_45
-O-antigen
-
-
-
0.00008948
55.0
LZS1_k127_3337342_5
TIGRFAM cell shape determining protein, MreB Mrl family
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695,K03696
-
-
7.006e-288
907.0
LZS1_k127_3352213_11
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
0.000001878
59.0
LZS1_k127_3352213_12
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K02356
-
-
0.000000000000000000000000000000000000000000324
164.0
LZS1_k127_407999_2
Responsible for synthesis of pseudouridine from uracil
This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K03101
-
3.4.23.36
0.00001898
52.0
LZS1_k127_4216235_0
NUDIX domain
-
-
-
0.0000000000000000000000196
104.0
LZS1_k127_4216235_1
Major intrinsic protein
K03441
-
-
0.00000000000000000000001979
105.0
LZS1_k127_4216235_2
phosphoglycerate mutase
K01834
-
5.4.2.11
0.00000000000000000001236
98.0
LZS1_k127_4216235_3
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
COGs COG0491 Zn-dependent hydrolase including glyoxylase
-
-
-
0.0000000000000000000000000000000000001024
150.0
LZS1_k127_4934316_18
Glycosyltransferase like family 2
-
-
-
0.0000000000000000000000000000000000001126
153.0
LZS1_k127_4934316_19
Methyltransferase small domain
-
-
-
0.00000000000000000000000000000000005728
148.0
LZS1_k127_4934316_2
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.0000000000000000000000000000000002488
146.0
LZS1_k127_4934316_21
Concanavalin A-like lectin/glucanases superfamily
-
-
-
0.000000000000000000000000000001405
143.0
LZS1_k127_4934316_22
-
-
-
-
0.00000000000000000000000000001548
121.0
LZS1_k127_4934316_23
PFAM Fic DOC family
-
-
-
0.00000000000000000000000007437
119.0
LZS1_k127_4934316_24
HEPN domain
-
-
-
0.0000000000000000000000001343
110.0
LZS1_k127_4934316_25
cellulase activity
K01178,K14645,K18546
-
3.2.1.3
0.0000000000000000000000001898
126.0
LZS1_k127_4934316_26
Vibrio cholerae RfbT protein
-
-
-
0.0000000000000000000000004052
115.0
LZS1_k127_4934316_27
-
-
-
-
0.0000000000000000000000118
105.0
LZS1_k127_4934316_28
Belongs to the UPF0102 family
K07460
-
-
0.0000000000000000000461
94.0
LZS1_k127_4934316_29
-
-
-
-
0.0000000000000000004283
88.0
LZS1_k127_4934316_3
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Orotidine 5'-phosphate decarboxylase / HUMPS family
K13421
-
2.4.2.10,4.1.1.23
0.000000000000000001366
93.0
LZS1_k127_4934316_31
Protein of unknown function DUF86
-
-
-
0.000000000000000001665
89.0
LZS1_k127_4934316_32
COG NOG14600 non supervised orthologous group
-
-
-
0.000000000000000002371
86.0
LZS1_k127_4934316_34
Protein of unknown function (DUF541)
K09807
-
-
0.00000000000000002422
91.0
LZS1_k127_4934316_35
PFAM Nucleotidyltransferase domain
K07075
-
-
0.0000000000000002168
81.0
LZS1_k127_4934316_36
7 transmembrane helices usually fused to an inactive transglutaminase
-
-
-
0.000000000000001327
87.0
LZS1_k127_4934316_37
Belongs to the RimK family
K05844,K14940
-
6.3.2.32
0.00000000000000179
87.0
LZS1_k127_4934316_38
HicA toxin of bacterial toxin-antitoxin,
-
-
-
0.0000000000002741
71.0
LZS1_k127_4934316_39
Probable zinc-ribbon domain
-
-
-
0.000000000004022
68.0
LZS1_k127_4934316_4
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base
-
-
-
0.0000003407
59.0
LZS1_k127_4934316_54
Copper amine oxidase domain protein
-
-
-
0.000006774
55.0
LZS1_k127_4934316_55
-
-
-
-
0.000007294
54.0
LZS1_k127_4934316_56
-
-
-
-
0.00001359
48.0
LZS1_k127_4934316_57
-
-
-
-
0.00001866
48.0
LZS1_k127_4934316_58
CARDB
-
-
-
0.00002063
59.0
LZS1_k127_4934316_59
-
-
-
-
0.00003024
47.0
LZS1_k127_4934316_6
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K02005,K13888
-
-
0.0000000000000001054
93.0
LZS1_k127_5131518_13
Protein of unknown function (DUF1573)
-
-
-
0.000357
50.0
LZS1_k127_5131518_2
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
-
-
-
0.00000000000004652
84.0
LZS1_k127_5351872_12
Lamin Tail Domain
-
-
-
0.00005279
54.0
LZS1_k127_5351872_13
phosphatidylinositol metabolic process
-
-
-
0.0002313
54.0
LZS1_k127_5351872_14
NYN domain
-
-
-
0.0004335
46.0
LZS1_k127_5351872_2
Fic/DOC family
K07341
-
-
0.000000000000000000000000000000000000000001384
160.0
LZS1_k127_5351872_3
PFAM Glycosyl transferase family 2
-
-
-
0.000000000000000000000000000000000000000002679
165.0
LZS1_k127_5351872_4
Glycosyl transferase family 2
K12984
-
-
0.000000000000000000000000000000000000002923
156.0
LZS1_k127_5351872_5
PFAM glycosyl transferase family 39
-
-
-
0.00000000000000000000000000000000276
146.0
LZS1_k127_5351872_6
nitric oxide dioxygenase activity
K00523
-
1.17.1.1
0.00000000000000000000000000000007577
134.0
LZS1_k127_5351872_7
bacterial-type flagellum assembly
-
-
-
0.0000000000000000205
84.0
LZS1_k127_5351872_8
integral membrane protein
-
-
-
0.00000000000000004064
93.0
LZS1_k127_5351872_9
PFAM VanZ family protein
-
-
-
0.0000000000000006785
83.0
LZS1_k127_5414172_0
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
9.484e-309
975.0
LZS1_k127_5414172_1
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K01356
-
3.4.21.88
0.00000000000000000000000000000000000000000001301
169.0
LZS1_k127_5414172_18
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K01159
-
3.1.22.4
0.00000000000000000000000000000000000000000001898
167.0
LZS1_k127_5414172_19
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
K03550
-
3.6.4.12
0.00000000000000000000000000005823
122.0
LZS1_k127_5414172_28
Bacterial extracellular solute-binding proteins, family 5 Middle
K02035
-
-
0.0000000000000000000000000888
121.0
LZS1_k127_5414172_29
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K00567
-
2.1.1.63
0.0000000000000000000000002129
109.0
LZS1_k127_5414172_3
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
3.89e-227
729.0
LZS1_k127_6229966_1
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K13292
-
-
0.000000000000000000000000000002058
129.0
LZS1_k127_6229966_3
COG COG0488 ATPase components of ABC transporters with duplicated ATPase domains
K15738
-
-
0.00000000000000000000000000002645
123.0
LZS1_k127_6229966_4
Proteolipid membrane potential modulator
-
-
-
0.000000000004861
68.0
LZS1_k127_6230028_0
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0
1102.0
LZS1_k127_6290633_1
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0
1100.0
LZS1_k127_6290633_10
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Could be involved in insertion of integral membrane proteins into the membrane
K08998
-
-
0.00000000000000006643
82.0
LZS1_k127_6290633_111
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Toxin-antitoxin system, toxin component, RelE family
-
-
-
0.00000000000000008932
83.0
LZS1_k127_6290633_113
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
K02892
-
-
0.000000000003047
70.0
LZS1_k127_6290633_125
Protein of unknown function (DUF4012)
-
-
-
0.000000000004893
80.0
LZS1_k127_6290633_126
Sortase family
K07284
-
3.4.22.70
0.000000000008361
75.0
LZS1_k127_6290633_127
Acetyltransferase (GNAT) domain
-
-
-
0.00000000001563
74.0
LZS1_k127_6290633_128
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.00000000001838
64.0
LZS1_k127_6290633_129
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.00000000003746
66.0
LZS1_k127_6290633_13
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.000001867
51.0
LZS1_k127_6290633_141
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K07447
-
-
0.000002295
54.0
LZS1_k127_6290633_143
PIN domain
-
-
-
0.000002897
55.0
LZS1_k127_6290633_144
Modulates RecA activity
K03565
-
-
0.000006552
54.0
LZS1_k127_6290633_145
SpoVT / AbrB like domain
-
-
-
0.000009081
50.0
LZS1_k127_6290633_146
-
-
-
-
0.00001293
56.0
LZS1_k127_6290633_147
4-amino-4-deoxy-L-arabinose transferase activity
-
-
-
0.00001562
57.0
LZS1_k127_6290633_149
cell adhesion involved in biofilm formation
-
-
-
0.00004401
55.0
LZS1_k127_6290633_15
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
1.572e-260
820.0
LZS1_k127_6290633_20
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D12 class N6 adenine-specific DNA methyltransferase
K07318
-
2.1.1.72
5.401e-249
782.0
LZS1_k127_6290633_30
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K02871
-
-
0.00000000000000000000000000000000000000000001053
166.0
LZS1_k127_6290633_62
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
0.00000000000000000000000000000000000000000001958
175.0
LZS1_k127_6290633_63
PFAM Glycosyl transferase family 4
K02851
-
2.7.8.33,2.7.8.35
0.0000000000000000000000000000000000000000001774
172.0
LZS1_k127_6290633_64
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K02874
-
-
0.000000000000000000000000000000000000002838
149.0
LZS1_k127_6290633_66
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K02988
-
-
0.0000000000000000000000000000000000000174
149.0
LZS1_k127_6290633_67
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
K00939
-
2.7.4.3
0.00000000000000000000000000000000000119
145.0
LZS1_k127_6290633_7
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
K01803
-
5.3.1.1
0.000000000000000000000000000000000008237
146.0
LZS1_k127_6290633_72
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K03664
-
-
0.0000000000000000000000000000001734
128.0
LZS1_k127_6290633_81
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
K00525
-
1.17.4.1
2.035e-233
750.0
LZS1_k127_6617603_1
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K00852
-
2.7.1.15
0.0000000000000006911
89.0
LZS1_k127_6617603_44
PIN domain
-
-
-
0.000000000000000703
83.0
LZS1_k127_6617603_45
ABC-type transport system involved in Fe-S cluster assembly, permease component
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
K03111
-
-
0.000000000000000000000000000000000000005149
151.0
LZS1_k127_7065843_12
Binds the 23S rRNA
K02909
-
-
0.00000000000000000000002578
104.0
LZS1_k127_7065843_13
NYN domain
-
-
-
0.000000000000002188
83.0
LZS1_k127_7065843_14
HIT family
K02503
-
-
0.000000000000005737
79.0
LZS1_k127_7065843_15
deoxyribonucleotide catabolic process
K01081
-
3.1.3.5
0.000000000000008341
74.0
LZS1_k127_7065843_16
Binds together with S18 to 16S ribosomal RNA
K02990
-
-
0.000000000001865
70.0
LZS1_k127_7065843_17
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.00000000002726
66.0
LZS1_k127_7065843_18
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
K03574
-
3.6.1.55
0.0000000000006652
74.0
LZS1_k127_7550397_21
PFAM NUDIX domain
K03574
-
3.6.1.55
0.00000000009761
68.0
LZS1_k127_7550397_22
Peptidase family M23
K21471
-
-
0.000000001149
70.0
LZS1_k127_7550397_23
-
-
-
-
0.000000008401
60.0
LZS1_k127_7550397_24
bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
-
-
-
0.0000001059
66.0
LZS1_k127_7550397_25
-
-
-
-
0.000007641
58.0
LZS1_k127_7550397_26
sequence-specific DNA binding
-
-
-
0.000008327
50.0
LZS1_k127_7550397_28
tail collar domain protein
-
-
-
0.000136
56.0
LZS1_k127_7550397_3
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K02563
-
2.4.1.227
0.000000000000000000000000000000000003393
152.0
LZS1_k127_7950885_11
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
-
-
-
0.0000000000000000000000000000000002609
141.0
LZS1_k127_7950885_12
MraZ protein, putative antitoxin-like
K03925
-
-
0.0000000000000000000000000000000005595
135.0
LZS1_k127_7950885_13
IMG reference gene
-
-
-
0.0000000000000000000000000000000212
131.0
LZS1_k127_7950885_14
Peptidase M16 inactive domain
-
-
-
0.00000000000000000000000008462
121.0
LZS1_k127_7950885_15
Putative RNA methylase family UPF0020
-
-
-
0.000000000000000000002407
104.0
LZS1_k127_7950885_16
Diacylglycerol kinase
K00887,K00901
-
2.7.1.107,2.7.1.66
0.00000000000000000001656
96.0
LZS1_k127_7950885_17
This protein binds to 23S rRNA in the presence of protein L20
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity