Overview

ID MAG02368
Name MMD2_bin.34
Sample SMP0059
Taxonomy
Kingdom Archaea
Phylum Micrarchaeota
Class Micrarchaeia
Order Anstonellales
Family Bilamarchaeaceae
Genus Bilamarchaeum
Species
Assembly information
Completeness (%) 85.03
Contamination (%) 1.2
GC content (%) 56.0
N50 (bp) 6,774
Genome size (bp) 1,270,075

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes837

Gene name Description KEGG GOs EC E-value Score Sequence
MMD2_k127_1003762_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000169 168.0
MMD2_k127_1003762_2 Transcriptional regulator, TrmB - - - 0.000000000000000000000002957 112.0
MMD2_k127_1027387_0 Ribosomal protein S8e K02995 - - 0.0000000000000000005288 91.0
MMD2_k127_1027387_1 - K09712,K14475 - - 0.000000003866 66.0
MMD2_k127_1031962_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000859 74.0
MMD2_k127_1035445_0 DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 428.0
MMD2_k127_1035445_1 Belongs to the UPF0218 family K09735 - - 0.00000000000000000578 90.0
MMD2_k127_1035445_2 Predicted membrane protein (DUF2085) - - - 0.000000000000166 79.0
MMD2_k127_1035445_3 PRC-barrel domain - - - 0.0001259 47.0
MMD2_k127_1057393_0 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000008505 77.0
MMD2_k127_1057393_1 COG0095 Lipoate-protein ligase A K03800 GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681 6.3.1.20 0.00000000001203 65.0
MMD2_k127_1057393_2 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.00000005122 56.0
MMD2_k127_106315_0 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000005584 168.0
MMD2_k127_106315_1 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000004251 122.0
MMD2_k127_106315_2 Belongs to the eukaryotic ribosomal protein eS28 family K02979 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904 - 0.00000000000000005296 87.0
MMD2_k127_106315_3 binds to the 23S rRNA K02896 - - 0.000000000000135 73.0
MMD2_k127_106315_4 E-Z type HEAT repeats - - - 0.0003748 51.0
MMD2_k127_1067832_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 1.025e-221 702.0
MMD2_k127_1067832_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 4.277e-213 670.0
MMD2_k127_1067832_10 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000007005 54.0
MMD2_k127_1067832_11 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00002336 54.0
MMD2_k127_1067832_2 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 346.0
MMD2_k127_1067832_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000001152 181.0
MMD2_k127_1067832_4 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000004726 147.0
MMD2_k127_1067832_5 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000001427 140.0
MMD2_k127_1067832_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000009861 126.0
MMD2_k127_1067832_7 Protein of unknown function (DUF541) K09807 - - 0.00000000002822 74.0
MMD2_k127_1067832_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000006998 61.0
MMD2_k127_1067832_9 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000002218 63.0
MMD2_k127_1091273_0 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 389.0
MMD2_k127_1091273_1 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 339.0
MMD2_k127_1091273_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 316.0
MMD2_k127_1091273_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 298.0
MMD2_k127_1091273_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000001607 140.0
MMD2_k127_1091273_5 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000008409 112.0
MMD2_k127_1091273_6 PFAM glutaredoxin - - - 0.000000000000001796 89.0
MMD2_k127_1091273_7 RNase L inhibitor K06174 - - 0.000000000002865 67.0
MMD2_k127_1091273_8 - - - - 0.000001044 60.0
MMD2_k127_1091273_9 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00161,K11381 - 1.2.4.1,1.2.4.4 0.0003525 44.0
MMD2_k127_1156328_0 Transcriptional regulator - - - 0.0000000000000000024 92.0
MMD2_k127_1159380_0 Beta-Casp domain K07041 - - 1.049e-196 631.0
MMD2_k127_1159380_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000001192 133.0
MMD2_k127_1159710_0 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 539.0
MMD2_k127_1159710_1 PFAM CobW HypB UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 289.0
MMD2_k127_1159710_2 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001324 278.0
MMD2_k127_1159710_3 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000008018 150.0
MMD2_k127_1159710_4 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000006916 143.0
MMD2_k127_1175505_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1094.0
MMD2_k127_1175505_1 Belongs to the CarA family K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004552 274.0
MMD2_k127_1206134_0 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 1.621e-204 644.0
MMD2_k127_1206134_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 559.0
MMD2_k127_1206134_10 Isochorismatase family - - - 0.00005511 53.0
MMD2_k127_1206134_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 306.0
MMD2_k127_1206134_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000008649 186.0
MMD2_k127_1206134_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001223 177.0
MMD2_k127_1206134_5 transcription regulator activity - - - 0.00000000000000000000000000000001129 132.0
MMD2_k127_1206134_6 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000374 129.0
MMD2_k127_1206134_7 PQQ-like domain - - - 0.0000000000000000000000000008203 130.0
MMD2_k127_1206134_8 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000004652 59.0
MMD2_k127_1206134_9 Isochorismatase family K01252,K20261 - 3.3.2.1,3.3.2.15,6.3.2.14 0.0000107 55.0
MMD2_k127_1269221_0 Peptidase family M50 - - - 0.0000000000000000000565 104.0
MMD2_k127_1269221_1 PFAM helix-turn-helix domain protein K03627 - - 0.00004342 49.0
MMD2_k127_1314477_0 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.0000000000000000000000000000000000000003882 154.0
MMD2_k127_1314477_1 E3 Ubiquitin ligase - - - 0.0002413 52.0
MMD2_k127_1332690_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 9.192e-204 652.0
MMD2_k127_1396044_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000005806 185.0
MMD2_k127_1396044_1 FMN binding - - - 0.00000000000000008951 87.0
MMD2_k127_1396044_2 DSBA-like thioredoxin domain - - - 0.00000000005126 66.0
MMD2_k127_1403643_0 DEAD DEAH box helicase domain protein K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 569.0
MMD2_k127_1403643_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 289.0
MMD2_k127_1403643_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.29 0.00000000000000000000000000000000004394 141.0
MMD2_k127_1403643_3 PFAM MgtC SapB transporter K07507 - - 0.000000000000000000000005015 107.0
MMD2_k127_1424148_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.464e-206 663.0
MMD2_k127_1424148_1 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000009582 193.0
MMD2_k127_1424148_2 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000003705 139.0
MMD2_k127_1424148_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000001098 79.0
MMD2_k127_1424148_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000002577 61.0
MMD2_k127_1424268_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 3.69e-244 785.0
MMD2_k127_1424268_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 4.182e-208 672.0
MMD2_k127_1424268_2 - - - - 0.00000000000000000000000000000000000000000000003394 186.0
MMD2_k127_1447572_0 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002792 259.0
MMD2_k127_1447572_1 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000000000000000000000000000001538 168.0
MMD2_k127_1447572_2 PFAM regulatory protein, MarR - - - 0.00000001992 63.0
MMD2_k127_1447572_3 Cupredoxin-like domain - - - 0.0000004031 58.0
MMD2_k127_1447572_4 Heavy-metal-associated domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00003569 49.0
MMD2_k127_1475987_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000189 295.0
MMD2_k127_1475987_1 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000001888 175.0
MMD2_k127_1475987_2 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.00000000000000000001411 96.0
MMD2_k127_1475987_3 negative regulation of centriole-centriole cohesion - - - 0.00000002879 63.0
MMD2_k127_1505234_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000436 235.0
MMD2_k127_1505234_1 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000003553 183.0
MMD2_k127_1505234_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000006983 134.0
MMD2_k127_1505234_3 Fe-S-cluster oxidoreductase K06940 - - 0.000000000000002171 87.0
MMD2_k127_1505234_4 PFAM Uncharacterised protein family (UPF0153) - - - 0.000003204 58.0
MMD2_k127_1505234_5 Zinc finger BED domain-containing protein RICESLEEPER - - - 0.0005028 53.0
MMD2_k127_1530738_0 Putative diphthamide synthesis protein K07561 GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016765,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0048037,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765 2.5.1.108 0.0000000000000000000000000000000000000000000000000000201 202.0
MMD2_k127_1530738_1 PhoU domain - - - 0.0000000000000000000000386 112.0
MMD2_k127_1565282_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 284.0
MMD2_k127_1565282_1 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000000000000000000007966 130.0
MMD2_k127_1583389_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 372.0
MMD2_k127_1583389_1 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000001222 176.0
MMD2_k127_162281_0 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000003393 194.0
MMD2_k127_162281_1 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000001457 130.0
MMD2_k127_162281_2 pfam nmd3 K07562 - - 0.0000000000000000003501 96.0
MMD2_k127_162281_3 Membrane protein of unknown function DUF63 - - - 0.0000000000001325 79.0
MMD2_k127_162281_4 ATPase histidine kinase DNA gyrase B HSP90 domain protein K00936 - 2.7.13.3 0.0002001 48.0
MMD2_k127_1653243_0 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000003301 204.0
MMD2_k127_1653243_1 prephenate dehydrogenase (NADP+) activity K00077,K00210,K06410,K14170,K16182 - 1.1.1.169,1.3.1.12,4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000001727 160.0
MMD2_k127_1671390_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 472.0
MMD2_k127_1671390_1 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000279 61.0
MMD2_k127_1671390_2 - - - - 0.00000001646 58.0
MMD2_k127_1694645_0 TIGRFAM geranylgeranyl reductase K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 325.0
MMD2_k127_1694645_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000007722 246.0
MMD2_k127_1694645_2 AAA domain K07028 - - 0.00000000000000000000002997 105.0
MMD2_k127_1694645_3 AAA domain K07028 - - 0.0000000000001084 72.0
MMD2_k127_1706710_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 2.384e-274 857.0
MMD2_k127_1706710_1 Isocitrate/isopropylmalate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 557.0
MMD2_k127_1706710_2 ATP-citrate synthase alpha chain protein K01648 GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005212 395.0
MMD2_k127_1706710_3 mTERF K15032 - - 0.0007723 51.0
MMD2_k127_1718784_0 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 306.0
MMD2_k127_1718784_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006281 274.0
MMD2_k127_1718784_10 cheY-homologous receiver domain - - - 0.00000000002465 74.0
MMD2_k127_1718784_11 CAAX amino terminal protease family protein K07052 - - 0.0000003567 59.0
MMD2_k127_1718784_12 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000003712 55.0
MMD2_k127_1718784_13 A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products K03552 - 3.1.22.4 0.00001018 53.0
MMD2_k127_1718784_2 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000009365 235.0
MMD2_k127_1718784_3 NYN domain - - - 0.0000000000000000000000000000000000000000000259 167.0
MMD2_k127_1718784_4 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000001202 121.0
MMD2_k127_1718784_5 Pfam:DUF258 - - - 0.00000000000000000000000002212 119.0
MMD2_k127_1718784_6 COG0084 Mg-dependent DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000001401 115.0
MMD2_k127_1718784_7 Belongs to the snRNP Sm proteins family K04796 - - 0.000000000000000000001947 95.0
MMD2_k127_1718784_8 PFAM response regulator receiver K02030 - - 0.0000000000007126 79.0
MMD2_k127_1718784_9 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000001815 70.0
MMD2_k127_1744264_0 Protein of unknown function (DUF460) K09150 - - 0.000000000000000003918 88.0
MMD2_k127_1744264_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000006472 77.0
MMD2_k127_1804452_0 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 405.0
MMD2_k127_1804452_1 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000001261 154.0
MMD2_k127_1804452_2 COG1522 Transcriptional regulators - - - 0.0000002254 62.0
MMD2_k127_1804452_3 helix_turn_helix ASNC type K03719 - - 0.0000007066 61.0
MMD2_k127_1804452_4 Golgi vesicle docking - GO:0000139,GO:0001650,GO:0002009,GO:0002165,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005794,GO:0005795,GO:0005798,GO:0005829,GO:0006810,GO:0006886,GO:0006888,GO:0006891,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0007030,GO:0007275,GO:0007346,GO:0007444,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008104,GO:0008150,GO:0008565,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010256,GO:0010389,GO:0010564,GO:0012505,GO:0012506,GO:0012507,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0019898,GO:0022406,GO:0022607,GO:0030133,GO:0030134,GO:0030135,GO:0030658,GO:0030659,GO:0030660,GO:0030662,GO:0031090,GO:0031312,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0033036,GO:0034613,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0042802,GO:0042886,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044452,GO:0044464,GO:0044719,GO:0045056,GO:0045184,GO:0046907,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0048211,GO:0048219,GO:0048278,GO:0048471,GO:0048513,GO:0048563,GO:0048569,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051726,GO:0060429,GO:0060562,GO:0061024,GO:0061025,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0090066,GO:0090114,GO:0090498,GO:0097708,GO:0098588,GO:0098791,GO:0098805,GO:0140056,GO:1901987,GO:1901990,GO:1902749 - 0.00006495 53.0
MMD2_k127_1804452_5 sequence-specific DNA binding - - - 0.00008175 54.0
MMD2_k127_1805237_0 Aspartate ammonia-lyase K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 422.0
MMD2_k127_1805237_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 377.0
MMD2_k127_1805237_2 DnaB-like helicase C terminal domain K08482 - - 0.0000000000000000000000000000000002789 140.0
MMD2_k127_1805237_3 calcium ion binding - - - 0.0000002317 63.0
MMD2_k127_1805237_4 Serine protease inhibitor - - - 0.0006493 51.0
MMD2_k127_1811575_0 2-methylcitrate dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 406.0
MMD2_k127_1811575_1 TIGRFAM TRAP transporter solute receptor, TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 315.0
MMD2_k127_1811575_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000007868 209.0
MMD2_k127_1811575_3 DNA replication protein - - - 0.00000000008007 64.0
MMD2_k127_1828842_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003261 276.0
MMD2_k127_1828842_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00003184 54.0
MMD2_k127_1834603_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 439.0
MMD2_k127_1834603_1 Chorismate mutase type II K04518,K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 421.0
MMD2_k127_1834603_2 prephenate dehydrogenase K00210 - 1.3.1.12 0.00000000000000000000000000000000573 134.0
MMD2_k127_1834603_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000001064 96.0
MMD2_k127_1849357_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 405.0
MMD2_k127_1849357_1 ribosomal protein S11 K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000005954 159.0
MMD2_k127_1849357_2 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000000000000366 156.0
MMD2_k127_1849357_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000002247 150.0
MMD2_k127_1849357_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000003859 145.0
MMD2_k127_1849357_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000001765 124.0
MMD2_k127_1849357_6 - - - - 0.00000000000000000000001579 103.0
MMD2_k127_1849357_7 Domain of unknown function (DUF1610) K07580 - - 0.0000000715 55.0
MMD2_k127_1849357_9 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0001368 47.0
MMD2_k127_187297_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 415.0
MMD2_k127_187297_1 PFAM NAD dependent epimerase dehydratase family K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000001079 149.0
MMD2_k127_187297_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000001902 147.0
MMD2_k127_1875873_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 414.0
MMD2_k127_1875873_1 PFAM Glycosyl transferase family 4 K01001 - 2.7.8.15 0.0000000000000000000000009359 110.0
MMD2_k127_187937_0 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 335.0
MMD2_k127_187937_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000002724 240.0
MMD2_k127_187937_2 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000001252 179.0
MMD2_k127_187937_3 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000003102 57.0
MMD2_k127_1882854_0 histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 432.0
MMD2_k127_1890445_0 COG0474 Cation transport ATPase K01537 - 3.6.3.8 8.23e-224 722.0
MMD2_k127_1890445_1 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000000001862 211.0
MMD2_k127_1890445_2 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000000000000000000001201 133.0
MMD2_k127_1890445_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000002622 102.0
MMD2_k127_1890445_4 Peptidyl-prolyl cis-trans K01802,K03768,K03775 - 5.2.1.8 0.000000000003355 78.0
MMD2_k127_1894218_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 388.0
MMD2_k127_1894218_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001262 293.0
MMD2_k127_1957008_0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 302.0
MMD2_k127_1957008_1 RecQ zinc-binding K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 306.0
MMD2_k127_1957008_2 RecQ zinc-binding K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000001496 211.0
MMD2_k127_1957008_3 CAAX amino Terminal protease family protein K07052 - - 0.0000000000000000000000000000000000000000000000045 183.0
MMD2_k127_1962032_0 SMART zinc finger, CDGSH-type domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 299.0
MMD2_k127_1962032_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001199 292.0
MMD2_k127_1962032_2 Nickel-dependent hydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001198 270.0
MMD2_k127_1962032_3 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000000000002441 149.0
MMD2_k127_1962032_4 nitric oxide dioxygenase activity K21405 - - 0.0000000000000000000000000000002752 132.0
MMD2_k127_1962032_5 Thioredoxin - - - 0.00000000000000000000000000001098 130.0
MMD2_k127_1962032_6 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.00000000000000005967 87.0
MMD2_k127_1962032_7 PFAM amino acid-binding ACT domain protein - - - 0.000000002536 63.0
MMD2_k127_1962032_8 EamA-like transporter family - - - 0.0000001135 56.0
MMD2_k127_1975481_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 530.0
MMD2_k127_197931_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 344.0
MMD2_k127_197931_1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000004645 244.0
MMD2_k127_197931_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000001419 102.0
MMD2_k127_197931_3 PFAM regulatory protein AsnC Lrp family K03718 - - 0.0000000000000006957 84.0
MMD2_k127_197931_4 COG1522 Transcriptional regulators - - - 0.00000000000006336 78.0
MMD2_k127_197931_5 - - - - 0.000001536 51.0
MMD2_k127_197931_6 Nodulation protein S (NodS) - - - 0.00038 53.0
MMD2_k127_2052526_0 Suppressor of fused protein (SUFU) - - - 0.00006446 52.0
MMD2_k127_2081109_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 9.892e-196 637.0
MMD2_k127_213209_0 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000003079 185.0
MMD2_k127_213209_1 Translation initiation factor 2, alpha subunit K03237 - - 0.00000000000000000000000000000000000000000001648 172.0
MMD2_k127_213209_2 binds to the 23S rRNA K02929 - - 0.0000000001332 66.0
MMD2_k127_213209_3 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K03658,K07466 - 3.6.4.12 0.000000002726 63.0
MMD2_k127_213209_4 PFAM ribosomal protein K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000004335 58.0
MMD2_k127_213209_5 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000001897 53.0
MMD2_k127_2203038_0 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000002524 149.0
MMD2_k127_2203038_1 Phosphoribosyl transferase domain K07101 - - 0.000000000003194 73.0
MMD2_k127_2257506_0 Aspartate carbamoyltransferase K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002683 289.0
MMD2_k127_2257506_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004528 287.0
MMD2_k127_2257506_10 Domain of unknown function (DUF4215) - - - 0.000000004776 70.0
MMD2_k127_2257506_11 PFAM peptidase M50 - - - 0.000004204 52.0
MMD2_k127_2257506_12 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.000005002 50.0
MMD2_k127_2257506_13 Caspase domain - - - 0.00002578 56.0
MMD2_k127_2257506_14 B-1 B cell differentiation - - - 0.00004233 57.0
MMD2_k127_2257506_15 Inner membrane component of T3SS, cytoplasmic domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.00004514 55.0
MMD2_k127_2257506_16 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0001579 50.0
MMD2_k127_2257506_17 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0004026 45.0
MMD2_k127_2257506_2 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259 - 0.0000000000000000000000000000000000000000000000000000000000000000003185 235.0
MMD2_k127_2257506_3 May be involved in maturation of the 30S ribosomal subunit K02966 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000002575 141.0
MMD2_k127_2257506_4 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000006176 146.0
MMD2_k127_2257506_5 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000007114 138.0
MMD2_k127_2257506_6 kinase Bud32 K08851 - 2.7.11.1 0.00000000000000000000000000000716 126.0
MMD2_k127_2257506_7 Domain of unknown function (DUF296) - - - 0.00000000000000000000003584 104.0
MMD2_k127_2257506_8 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000009833 100.0
MMD2_k127_2257506_9 Belongs to the ribosomal protein L31e family K02910 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000422 83.0
MMD2_k127_230690_0 VIT family - - - 0.00000000000000000000000000000000001326 145.0
MMD2_k127_230690_1 Protein phosphatase 2C K20074 - 3.1.3.16 0.000000005823 69.0
MMD2_k127_230690_2 PFAM Protein phosphatase K20074 - 3.1.3.16 0.0007505 54.0
MMD2_k127_2307454_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 445.0
MMD2_k127_2307454_1 Protease prsW family - - - 0.000000000000000000000000000000000000000000000001846 192.0
MMD2_k127_2307454_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000004604 149.0
MMD2_k127_2307454_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000001244 101.0
MMD2_k127_2307454_4 Transcriptional regulator K07729 - - 0.000000000000000001286 86.0
MMD2_k127_2307454_5 ABC transporter - - - 0.0003321 54.0
MMD2_k127_231001_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000001896 184.0
MMD2_k127_231001_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000007078 163.0
MMD2_k127_231001_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000006103 150.0
MMD2_k127_231001_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000001638 139.0
MMD2_k127_231001_4 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000724 85.0
MMD2_k127_231001_5 Ribosomal protein S29 K02980 GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904 - 0.0000000004574 61.0
MMD2_k127_2327032_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 519.0
MMD2_k127_2327032_1 S-adenosylmethionine synthetase K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 495.0
MMD2_k127_2327032_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000006367 114.0
MMD2_k127_2343817_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 463.0
MMD2_k127_2343817_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004756 285.0
MMD2_k127_2343817_2 SMART KH domain protein K06961 - - 0.00000000000000000000000000000000000000003887 158.0
MMD2_k127_2343817_3 FAD binding domain K10960,K21401 - 1.3.1.111,1.3.1.83,1.3.99.38 0.00000000000000000000000000000001847 141.0
MMD2_k127_2343817_4 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000251 134.0
MMD2_k127_2343817_5 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0002902 47.0
MMD2_k127_2442879_0 PilZ domain K08884 - 2.7.11.1 0.000000000000000000000000000000001683 141.0
MMD2_k127_2442879_1 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000003867 119.0
MMD2_k127_2442879_2 zinc metalloprotease whose natural substrate is K06974 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000001148 108.0
MMD2_k127_2443946_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000234 153.0
MMD2_k127_2443946_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000001751 114.0
MMD2_k127_2443946_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000001896 66.0
MMD2_k127_2448491_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 294.0
MMD2_k127_2448491_1 GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000003552 153.0
MMD2_k127_2448491_2 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000004636 131.0
MMD2_k127_2448491_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000001373 91.0
MMD2_k127_2448491_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000007384 84.0
MMD2_k127_2471419_0 dUTP biosynthetic process K01494 - 3.5.4.13 0.000000000000000000000000000001996 126.0
MMD2_k127_2471419_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03014,K03055 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000001678 69.0
MMD2_k127_2471419_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000007517 66.0
MMD2_k127_2471419_3 Acetyltransferase (GNAT) domain K03825 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.000001213 61.0
MMD2_k127_2472349_0 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000008406 205.0
MMD2_k127_2472349_1 Iron hydrogenase small subunit K00336,K18332 - 1.12.1.3,1.6.5.3 0.00000000000000000002005 96.0
MMD2_k127_2472349_2 Belongs to the UPF0218 family K09735 - - 0.000000000000000007039 95.0
MMD2_k127_2472349_3 PRC-barrel domain protein - - - 0.000885 46.0
MMD2_k127_2507377_0 - - - - 0.00000000000000000001056 104.0
MMD2_k127_2508464_0 - - - - 0.0000349 55.0
MMD2_k127_2535827_0 ERCC4 domain K10896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 337.0
MMD2_k127_2535827_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008205 263.0
MMD2_k127_2535827_2 Glycinamide ribonucleotide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000008821 232.0
MMD2_k127_2535827_3 HELICc2 K03722,K10844 - 3.6.4.12 0.000000000000000000000000000000000000000000000000002532 203.0
MMD2_k127_2535827_4 ICC-like phosphoesterases K06953 - - 0.0000000000000000000000000000000005046 139.0
MMD2_k127_2535827_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000004637 125.0
MMD2_k127_2535827_6 PBS lyase HEAT domain protein repeat-containing protein K22221 - - 0.000008062 55.0
MMD2_k127_2577196_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 299.0
MMD2_k127_2577196_1 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000004192 171.0
MMD2_k127_2577196_2 transferase activity, transferring nitrogenous groups K07767,K11358,K14293 GO:0000096,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006555,GO:0006558,GO:0006568,GO:0006569,GO:0006570,GO:0006576,GO:0006586,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009314,GO:0009416,GO:0009628,GO:0009639,GO:0009641,GO:0009698,GO:0009850,GO:0009851,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010252,GO:0010326,GO:0010364,GO:0010366,GO:0010565,GO:0010600,GO:0010817,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019222,GO:0019439,GO:0019748,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031335,GO:0031336,GO:0032350,GO:0032351,GO:0032353,GO:0033238,GO:0033239,GO:0034641,GO:0042402,GO:0042430,GO:0042436,GO:0042445,GO:0042446,GO:0042592,GO:0042762,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045763,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046885,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051175,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090354,GO:0090356,GO:0090357,GO:1900908,GO:1900909,GO:1900911,GO:1900912,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901996,GO:1901997,GO:1902221 2.6.1.1,3.6.4.3 0.000000000000000005723 97.0
MMD2_k127_2577196_3 Nucleic acid binding OB-fold tRNA helicase-type K07463 - - 0.00000000000000003884 94.0
MMD2_k127_2583584_0 aspartate--ammonia ligase K01914 - 6.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 381.0
MMD2_k127_2583584_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.00000000000000000000000000000000005546 136.0
MMD2_k127_2586590_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000003705 215.0
MMD2_k127_2586590_1 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000004397 160.0
MMD2_k127_2586590_2 PFAM periplasmic copper-binding - - - 0.00000000002498 78.0
MMD2_k127_2586590_3 DDE superfamily endonuclease - - - 0.00002211 54.0
MMD2_k127_2613932_0 type II secretion system protein K07332 - - 0.00000000000000000000000000000000000000000000000000000000000002751 233.0
MMD2_k127_2623475_0 metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain K07041 - - 0.0000000000000006749 81.0
MMD2_k127_2626215_0 SPFH domain-Band 7 family - - - 0.0006493 49.0
MMD2_k127_2628666_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000029 120.0
MMD2_k127_2628666_1 transcription regulator activity - - - 0.000000000000000002762 89.0
MMD2_k127_2628666_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000006724 56.0
MMD2_k127_2630266_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 307.0
MMD2_k127_2630266_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000002175 268.0
MMD2_k127_2630266_2 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.0000000000000000007465 92.0
MMD2_k127_2630266_3 transcription termination protein NusA K02600 - - 0.000000000002424 74.0
MMD2_k127_2632252_0 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 417.0
MMD2_k127_2632252_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000003404 149.0
MMD2_k127_2642136_0 WD40 domain protein beta Propeller K03641 - - 0.000000000000000000001432 107.0
MMD2_k127_2740922_0 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000003348 141.0
MMD2_k127_2740922_1 UMP catabolic process K01101,K02566 - 3.1.3.41 0.000000000000000000000000000000006312 131.0
MMD2_k127_2740922_2 SMART Metal-dependent phosphohydrolase, HD region K07023 - - 0.00000000000000000000000000000001768 133.0
MMD2_k127_2740922_3 Winged helix-turn-helix DNA-binding - - - 0.00000000000000004947 89.0
MMD2_k127_275502_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000005702 214.0
MMD2_k127_275502_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000002103 123.0
MMD2_k127_275502_2 Domain of unknown function (DUF202) K00389 - - 0.00000000000008086 74.0
MMD2_k127_2832667_0 PFAM Aldehyde dehydrogenase K22187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 585.0
MMD2_k127_2832667_1 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.000000000000000000007915 98.0
MMD2_k127_285382_0 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003682 276.0
MMD2_k127_285382_1 Acyl-CoA synthetase (NDP forming) K01905,K18594,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000519 187.0
MMD2_k127_285382_2 HD domain - - - 0.0000133 54.0
MMD2_k127_2880938_0 - - - - 0.0000000000000000000000000000000000000000000009704 168.0
MMD2_k127_2880938_1 Domain of unknown function (DUF4389) - - - 0.00001962 50.0
MMD2_k127_2888164_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 375.0
MMD2_k127_2888164_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008489 276.0
MMD2_k127_2888164_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000005699 74.0
MMD2_k127_2888164_3 Possibly the antitoxin component of a - - - 0.0001479 46.0
MMD2_k127_2907494_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 459.0
MMD2_k127_2907494_1 oxidoreductase beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000002963 113.0
MMD2_k127_2995254_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 555.0
MMD2_k127_2995254_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 561.0
MMD2_k127_2995254_10 Transcriptional regulator, PadR-like family - - - 0.0000000007614 65.0
MMD2_k127_2995254_11 ParB-like nuclease domain - - - 0.000002425 55.0
MMD2_k127_2995254_12 COG1361 S-layer domain - - - 0.000002625 60.0
MMD2_k127_2995254_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 301.0
MMD2_k127_2995254_3 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 293.0
MMD2_k127_2995254_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005611 259.0
MMD2_k127_2995254_5 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000003602 199.0
MMD2_k127_2995254_6 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000001713 203.0
MMD2_k127_2995254_7 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000003181 200.0
MMD2_k127_2995254_8 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000008018 115.0
MMD2_k127_2995254_9 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000000000001214 114.0
MMD2_k127_3032156_0 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000003969 161.0
MMD2_k127_3032156_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000102 152.0
MMD2_k127_3032156_2 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000001785 68.0
MMD2_k127_3032156_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000001796 62.0
MMD2_k127_3032156_4 Domain of unknown function (DUF1805) - - - 0.00004166 50.0
MMD2_k127_3032156_5 COG1994 Zn-dependent proteases - - - 0.00004999 55.0
MMD2_k127_3032156_6 Belongs to the eukaryotic ribosomal protein eS26 family K02976 - - 0.0005076 46.0
MMD2_k127_3049552_0 Metallopeptidase family M24 K01271 - 3.4.13.9 0.0000000000000000000000000000009714 135.0
MMD2_k127_3049552_1 Fcf1 K07158 - - 0.000000000000005922 79.0
MMD2_k127_3050995_0 GTPase of unknown function C-terminal K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 386.0
MMD2_k127_3050995_1 PFAM Ankyrin repeat K06867 - - 0.0000000000000000000000000000000000000000000000000000000003458 222.0
MMD2_k127_3050995_10 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000006877 57.0
MMD2_k127_3050995_11 transcriptional K03719 - - 0.0000004836 61.0
MMD2_k127_3050995_2 N-terminal domain of NWD NACHT-NTPase K21440 - - 0.0000000000000000000000000000000000216 145.0
MMD2_k127_3050995_3 Nitroreductase family - - - 0.000000000000000000000000000001136 128.0
MMD2_k127_3050995_4 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000007559 114.0
MMD2_k127_3050995_5 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000006325 100.0
MMD2_k127_3050995_6 Ankyrin repeat - - - 0.00000000000000000168 94.0
MMD2_k127_3050995_7 COG1522 Transcriptional regulators - - - 0.000000000000001628 87.0
MMD2_k127_3050995_8 DNA binding protein - - - 0.0000000000003417 77.0
MMD2_k127_3050995_9 protein localization to T-tubule K10380,K15503,K21440 - - 0.000000002187 66.0
MMD2_k127_3106831_0 DNA ligase K07468 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000007974 226.0
MMD2_k127_3106831_1 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000002519 184.0
MMD2_k127_3106831_2 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000919 133.0
MMD2_k127_3167328_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 359.0
MMD2_k127_3167328_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000001794 181.0
MMD2_k127_3167328_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000002344 172.0
MMD2_k127_3184694_0 lipolytic protein G-D-S-L family - - - 0.000006431 57.0
MMD2_k127_3206813_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000003279 243.0
MMD2_k127_3219564_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 414.0
MMD2_k127_3219564_1 PFAM Glutamine synthetase, catalytic K01915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 304.0
MMD2_k127_3219564_2 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000004832 189.0
MMD2_k127_3277366_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004085 275.0
MMD2_k127_3277366_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000005409 229.0
MMD2_k127_3277366_2 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000002984 173.0
MMD2_k127_3277366_3 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000006038 85.0
MMD2_k127_3286664_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 338.0
MMD2_k127_3286664_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000001221 162.0
MMD2_k127_3286664_2 Caspase domain - - - 0.00000000000000000000000000000000000000007101 162.0
MMD2_k127_3286664_3 IA, variant 3 - - - 0.0000000000000000000000000000000000000043 153.0
MMD2_k127_3286664_4 Belongs to the UPF0147 family K09721 - - 0.00000000000002867 76.0
MMD2_k127_3286664_5 tRNA intron endonuclease K01170 - 4.6.1.16 0.0000000001465 71.0
MMD2_k127_3286664_6 DnaJ molecular chaperone homology domain - - - 0.0000001672 61.0
MMD2_k127_3286664_7 2Fe-2S iron-sulfur cluster binding domain - - - 0.000002145 53.0
MMD2_k127_3286664_8 PFAM PRC-barrel domain - - - 0.000002831 53.0
MMD2_k127_3286664_9 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000003005 57.0
MMD2_k127_3316044_0 methylthiotransferase activity K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 318.0
MMD2_k127_3316044_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 315.0
MMD2_k127_3316044_2 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000000000000000000000000000000000000001846 206.0
MMD2_k127_3316044_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000002432 131.0
MMD2_k127_3316044_4 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000002553 99.0
MMD2_k127_3316044_5 binds to the 23S rRNA K02876 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000009725 94.0
MMD2_k127_3328515_0 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 347.0
MMD2_k127_3328515_1 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000001315 145.0
MMD2_k127_3328515_2 Binds the lower part of the 30S subunit head K02982 GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001682 145.0
MMD2_k127_3328515_3 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000002375 108.0
MMD2_k127_3328515_4 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000004908 107.0
MMD2_k127_3328515_5 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000006349 90.0
MMD2_k127_3328515_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000004018 73.0
MMD2_k127_3328515_7 ribosomal protein L24 K02895 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000011 68.0
MMD2_k127_3344660_0 Related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000008999 241.0
MMD2_k127_3344660_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 0.00000000000000000000000000000000000000000000000000000001525 204.0
MMD2_k127_3400081_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000008132 143.0
MMD2_k127_3400081_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000003041 78.0
MMD2_k127_3402868_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 479.0
MMD2_k127_3402868_1 phosphoesterase RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009775 265.0
MMD2_k127_3402868_2 - - - - 0.00000000000000006636 87.0
MMD2_k127_3402868_3 membrane - - - 0.000001165 57.0
MMD2_k127_3474946_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 GO:0000166,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016208,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042301,GO:0042737,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576 2.4.2.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 436.0
MMD2_k127_3474946_1 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000041 289.0
MMD2_k127_3474946_10 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000001024 102.0
MMD2_k127_3474946_11 helix_turn_helix ASNC type - - - 0.00000000000000000005522 96.0
MMD2_k127_3474946_12 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000004561 87.0
MMD2_k127_3474946_13 - K02928 - - 0.0004827 44.0
MMD2_k127_3474946_14 N-acetyltransferase K21935 - 2.3.1.264 0.0008021 51.0
MMD2_k127_3474946_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001139 278.0
MMD2_k127_3474946_3 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000000000522 216.0
MMD2_k127_3474946_4 Belongs to the eIF-2B alpha beta delta subunits family K18237 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.29 0.000000000000000000000000000000000000000000000000000007859 201.0
MMD2_k127_3474946_5 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000009096 139.0
MMD2_k127_3474946_6 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000000000000000000000002252 134.0
MMD2_k127_3474946_7 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000003805 126.0
MMD2_k127_3474946_8 succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.00000000000000000000000008287 122.0
MMD2_k127_3474946_9 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000001002 107.0
MMD2_k127_3490155_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000001661 167.0
MMD2_k127_3490155_1 membrane - - - 0.000001426 51.0
MMD2_k127_3507541_0 DEAD DEAH box helicase K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006306 289.0
MMD2_k127_3507541_1 Glutaredoxin - - - 0.000000000000002994 78.0
MMD2_k127_3507541_2 tRNA-4-demethylwyosine synthase activity K15449 - 4.1.3.44 0.00003947 48.0
MMD2_k127_3544773_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 5.101e-245 781.0
MMD2_k127_3544773_1 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.0000000000000000000000000000000000008594 141.0
MMD2_k127_3581595_0 TIGRFAM FeS assembly protein SufB K09014 - - 0.000000000000000000000000000001675 121.0
MMD2_k127_3581595_1 Fe-S cluster assembly K07033,K09015 - - 0.00000000000000000000001307 109.0
MMD2_k127_3592314_0 PFAM Chaperonin Cpn60 TCP-1 K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 609.0
MMD2_k127_3605638_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000003067 273.0
MMD2_k127_3631901_0 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000004781 213.0
MMD2_k127_369271_0 Periplasmic copper-binding protein (NosD) - - - 0.0000000000277 78.0
MMD2_k127_369952_0 protein catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005863 264.0
MMD2_k127_3699935_0 AAA-like domain K06915 - - 0.000000008103 68.0
MMD2_k127_3797990_0 AP endonuclease family 2 K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000009494 222.0
MMD2_k127_3797990_1 HAD-superfamily hydrolase, subfamily IA, variant 1 K07025 - - 0.0000000000000000000000000000000000000000000000002055 184.0
MMD2_k127_3797990_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000006902 166.0
MMD2_k127_3817703_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 365.0
MMD2_k127_3817703_1 Alpha amylase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 359.0
MMD2_k127_3817703_2 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000001897 216.0
MMD2_k127_3941053_0 prohibitin homologues - - - 0.0000000006496 64.0
MMD2_k127_3972436_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000008691 189.0
MMD2_k127_3972436_1 regulatory protein, arsR - - - 0.000000002482 66.0
MMD2_k127_3972436_2 Tetratricopeptide repeat - - - 0.0004458 49.0
MMD2_k127_4047065_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1154.0
MMD2_k127_4047065_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.508e-246 776.0
MMD2_k127_4047065_2 TIGRFAM excinuclease ABC, C subunit K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000288 233.0
MMD2_k127_4047065_3 NADPH-quinone reductase (modulator of drug activity B) K00355 - 1.6.5.2 0.0000000000000000000000000002174 121.0
MMD2_k127_4047520_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 494.0
MMD2_k127_4047520_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 436.0
MMD2_k127_4047520_2 Phenylalanyl-tRNA synthetase beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 339.0
MMD2_k127_4047520_3 ABC transporter K02049,K15555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 298.0
MMD2_k127_4047520_4 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004964 271.0
MMD2_k127_4047520_5 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.00000000000000006875 82.0
MMD2_k127_4047520_6 Succinyl-CoA ligase like flavodoxin domain K09181 - - 0.0000002512 58.0
MMD2_k127_4047520_7 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797,K01611 - 2.5.1.16,4.1.1.50 0.00004451 51.0
MMD2_k127_4090950_0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 396.0
MMD2_k127_4090950_1 COG0402 Cytosine deaminase and related metal-dependent hydrolases K01485,K01487 - 3.5.4.1,3.5.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 322.0
MMD2_k127_4090950_2 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000692 170.0
MMD2_k127_4090950_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.0000000000000000000000000000000001072 134.0
MMD2_k127_4090950_4 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000007413 90.0
MMD2_k127_4111807_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 431.0
MMD2_k127_4111807_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000059 138.0
MMD2_k127_4111807_2 helix_turn_helix ASNC type K03719,K05800 - - 0.00000005346 60.0
MMD2_k127_4123538_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00001496 57.0
MMD2_k127_4167987_0 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 505.0
MMD2_k127_4167987_1 DNA polymerase K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 514.0
MMD2_k127_4167987_10 ParB-like nuclease domain - - - 0.000000000000005286 85.0
MMD2_k127_4167987_11 - - - - 0.000000001839 67.0
MMD2_k127_4167987_12 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000001035 63.0
MMD2_k127_4167987_2 Protein of unknown function (DUF475) K09799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 418.0
MMD2_k127_4167987_3 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000002259 274.0
MMD2_k127_4167987_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000521 213.0
MMD2_k127_4167987_5 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000008644 218.0
MMD2_k127_4167987_6 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000001508 199.0
MMD2_k127_4167987_7 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000289 187.0
MMD2_k127_4167987_8 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000003979 193.0
MMD2_k127_4167987_9 Glutaredoxin - - - 0.000000000000000007995 88.0
MMD2_k127_4169200_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 523.0
MMD2_k127_4169200_1 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000005323 213.0
MMD2_k127_4169200_2 Ankyrin repeat - - - 0.00000000000000000000000000000000006294 148.0
MMD2_k127_4169200_3 ABC transporter K01992 - - 0.00000001861 68.0
MMD2_k127_4169200_5 PFAM ABC-2 type transporter K01992 - - 0.000002058 61.0
MMD2_k127_4169200_7 Acetyltransferase (GNAT) domain - - - 0.0008567 50.0
MMD2_k127_4194979_0 alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000009113 259.0
MMD2_k127_4194979_1 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000233 215.0
MMD2_k127_4194979_2 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000002434 209.0
MMD2_k127_4194979_3 Metallo-beta-lactamase - - - 0.0001422 45.0
MMD2_k127_4212427_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 1.094e-227 720.0
MMD2_k127_4212427_1 Belongs to the RNA polymerase beta chain family K03045 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 478.0
MMD2_k127_4212427_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000003615 72.0
MMD2_k127_4222049_0 asparaginyl-tRNA aminoacylation K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 457.0
MMD2_k127_4222049_1 Chondroitinase B - - - 0.0000003094 63.0
MMD2_k127_4222049_2 Tetratricopeptide repeat - - - 0.0007883 52.0
MMD2_k127_423544_0 Transcriptional regulator PadR-like family - - - 0.00000000000000001334 87.0
MMD2_k127_423544_1 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000001341 90.0
MMD2_k127_423544_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000006543 78.0
MMD2_k127_4281718_0 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000005651 201.0
MMD2_k127_4281718_1 Involved in protein export K03074 - - 0.00000000000000000000000000000007386 139.0
MMD2_k127_4310266_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 524.0
MMD2_k127_4310266_1 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000002843 194.0
MMD2_k127_4310266_2 phosphate transporter K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000003538 121.0
MMD2_k127_4314544_0 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000625 273.0
MMD2_k127_4314544_1 NAD-dependent epimerase dehydratase K01784,K03274 - 5.1.3.2,5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000004667 222.0
MMD2_k127_4314544_2 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000004832 210.0
MMD2_k127_4314544_3 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000001486 193.0
MMD2_k127_4314544_4 Polysaccharide biosynthesis protein - - - 0.00000000000000000000002167 115.0
MMD2_k127_4314544_5 DUF167 K09131 - - 0.00001885 53.0
MMD2_k127_4322197_0 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000007467 229.0
MMD2_k127_4322197_1 oligosaccharyl transferase activity - - - 0.000000000000003433 86.0
MMD2_k127_4322197_2 glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000003796 75.0
MMD2_k127_4351562_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 1.044e-220 701.0
MMD2_k127_4351562_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00058 - 1.1.1.399,1.1.1.95 0.00007821 51.0
MMD2_k127_4353196_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000001029 235.0
MMD2_k127_4353196_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000001701 198.0
MMD2_k127_4432565_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 491.0
MMD2_k127_4432565_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 349.0
MMD2_k127_4432565_2 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000002669 211.0
MMD2_k127_4432565_3 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000000000000000000000000000000000000001784 160.0
MMD2_k127_4432565_4 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000009523 134.0
MMD2_k127_4432565_5 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000001191 69.0
MMD2_k127_4432565_6 COG4962 Flp pilus assembly protein, ATPase CpaF K02283 - - 0.0000000004881 73.0
MMD2_k127_4432565_7 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000001402 61.0
MMD2_k127_4443918_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 578.0
MMD2_k127_4443918_1 MarR family transcriptional regulator - - - 0.000000000000000000000000000000000000001318 151.0
MMD2_k127_4457563_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000009005 124.0
MMD2_k127_4457563_1 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.000000000000007529 82.0
MMD2_k127_4457563_2 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.00000000001179 68.0
MMD2_k127_4457563_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000002411 63.0
MMD2_k127_4457563_4 phytol kinase activity K15892 - 2.7.1.216 0.00000004907 63.0
MMD2_k127_4457563_5 type II secretion K07333 - - 0.00002351 56.0
MMD2_k127_4484493_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 547.0
MMD2_k127_4484493_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 444.0
MMD2_k127_4484493_2 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 302.0
MMD2_k127_4484493_3 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000006292 209.0
MMD2_k127_4484493_4 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000001389 194.0
MMD2_k127_4484493_5 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000009047 168.0
MMD2_k127_4504419_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 2.963e-264 838.0
MMD2_k127_4504419_1 Heat shock 70 kDa protein K04043 - - 3.204e-248 781.0
MMD2_k127_4504419_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000001919 113.0
MMD2_k127_4504419_3 Right handed beta helix region - - - 0.0000000000000000000006151 112.0
MMD2_k127_4504419_4 unfolded protein binding K09507,K09510,K09511 GO:0000122,GO:0001671,GO:0002682,GO:0002684,GO:0003674,GO:0003712,GO:0003714,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008047,GO:0008134,GO:0008150,GO:0008593,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0014069,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0023051,GO:0023057,GO:0030234,GO:0030425,GO:0030544,GO:0031072,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031647,GO:0031974,GO:0031981,GO:0032279,GO:0032781,GO:0033554,GO:0035966,GO:0036477,GO:0042221,GO:0042689,GO:0042691,GO:0042995,GO:0043005,GO:0043025,GO:0043085,GO:0043197,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043462,GO:0043618,GO:0043620,GO:0044087,GO:0044093,GO:0044297,GO:0044309,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044445,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045202,GO:0045595,GO:0045597,GO:0045610,GO:0045612,GO:0045746,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050821,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051094,GO:0051117,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0051336,GO:0051345,GO:0051716,GO:0060255,GO:0060589,GO:0060590,GO:0061077,GO:0061827,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090083,GO:0090084,GO:0097201,GO:0097223,GO:0097447,GO:0097458,GO:0098772,GO:0098794,GO:0098984,GO:0099522,GO:0099524,GO:0099572,GO:0120025,GO:0120038,GO:0140110,GO:1900034,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000001669 73.0
MMD2_k127_4504419_5 Bacterial regulatory protein, arsR family - - - 0.000000003952 63.0
MMD2_k127_4563845_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 361.0
MMD2_k127_4563845_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17723,K17828 - 1.3.1.1,1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007734 284.0
MMD2_k127_4563845_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.0000000000000000000000000000000000000000000000000003609 194.0
MMD2_k127_4563845_3 - - - - 0.00000000000000000000000000000000000000000000000003534 190.0
MMD2_k127_4563845_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.00000000000000000000000000000000669 133.0
MMD2_k127_4563845_5 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000001541 62.0
MMD2_k127_4563845_6 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00009516 52.0
MMD2_k127_4580564_0 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000004084 121.0
MMD2_k127_4592739_0 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.0000000000000000000000000000000000008459 150.0
MMD2_k127_4592739_1 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000002262 132.0
MMD2_k127_4592739_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00311,K17830 - 1.3.1.101,1.3.7.11,1.5.5.1 0.0000000000000005364 80.0
MMD2_k127_4592739_3 Putative Fe-S cluster - - - 0.00000001397 59.0
MMD2_k127_4654573_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 348.0
MMD2_k127_4656060_0 PP-loop family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008125 280.0
MMD2_k127_4656060_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000002443 230.0
MMD2_k127_4700483_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 6.337e-240 765.0
MMD2_k127_4705102_0 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 339.0
MMD2_k127_4705102_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007273 253.0
MMD2_k127_4705102_2 DJ-1/PfpI family K03152,K05520,K05687 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000005414 192.0
MMD2_k127_4705102_3 AhpC/TSA family K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000004111 177.0
MMD2_k127_4705102_4 PFAM PEBP family protein K06910 - - 0.0000000000000000000000000000000000000000000000062 176.0
MMD2_k127_4705102_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000131 175.0
MMD2_k127_4705102_6 Secreted repeat of unknown function - - - 0.0000000000000000000000006904 113.0
MMD2_k127_4705102_7 Glyoxalase-like domain K06996 - - 0.00000000000000000006552 94.0
MMD2_k127_4705102_8 Protein of unknown function (DUF2892) - - - 0.0000001635 57.0
MMD2_k127_4893791_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 454.0
MMD2_k127_4893791_1 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 323.0
MMD2_k127_4893791_2 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 310.0
MMD2_k127_4893791_3 phosphohydrolase K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004329 251.0
MMD2_k127_4893791_4 PAC2 family K06869 - - 0.00000000000000000000000001909 120.0
MMD2_k127_4893791_5 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000006878 56.0
MMD2_k127_4893791_6 PFAM regulatory protein AsnC Lrp family K03719 - - 0.00004689 55.0
MMD2_k127_4893791_7 PFAM amino acid-binding ACT domain protein - - - 0.0001465 50.0
MMD2_k127_4906287_0 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002441 273.0
MMD2_k127_4906287_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000001544 83.0
MMD2_k127_4912150_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 352.0
MMD2_k127_4912150_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 299.0
MMD2_k127_4912150_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.00000000000000000000000000000000000003707 145.0
MMD2_k127_4921688_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000004025 215.0
MMD2_k127_4921688_1 GHMP kinases C terminal K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000001542 191.0
MMD2_k127_4921688_2 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000001859 157.0
MMD2_k127_4921688_3 PFAM periplasmic copper-binding - - - 0.000003769 57.0
MMD2_k127_4973330_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006039 315.0
MMD2_k127_4973330_1 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000001757 223.0
MMD2_k127_4973330_2 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000002542 169.0
MMD2_k127_4973330_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000003746 142.0
MMD2_k127_4973330_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000004652 61.0
MMD2_k127_5060954_0 xanthine phosphoribosyltransferase activity K00769,K07101 - 2.4.2.22 0.00000000000000000000000000000000000000000007301 164.0
MMD2_k127_5072417_0 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K03574 - 3.6.1.55 0.0000000000000000000008665 100.0
MMD2_k127_5072417_1 - - - - 0.000000000000001094 80.0
MMD2_k127_5072417_2 Predicted membrane protein (DUF2207) - - - 0.00000000000715 76.0
MMD2_k127_5100314_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 472.0
MMD2_k127_5100314_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 311.0
MMD2_k127_5100314_2 Protein of unknown function (DUF429) K09147 - - 0.00000000000000000000000000000000000000000006464 166.0
MMD2_k127_5100314_3 Spermine/spermidine synthase domain K06983 - - 0.00000000000000000000000000000000000000005595 160.0
MMD2_k127_5100314_4 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 0.00000000000000002236 89.0
MMD2_k127_5120358_0 PFAM beta-lactamase domain protein K07577 - - 0.0000000000000000000000000000000000000000000000000007838 192.0
MMD2_k127_5120358_1 PFAM PHP domain protein - - - 0.000000000000000000000000000000000009043 145.0
MMD2_k127_5120358_2 Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis - - - 0.00000000000000003149 91.0
MMD2_k127_5120358_3 Ion channel - - - 0.0000000000000523 77.0
MMD2_k127_5120358_4 DnaJ molecular chaperone homology domain - - - 0.000004527 60.0
MMD2_k127_5169528_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 1.854e-209 676.0
MMD2_k127_5207862_0 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 4.975e-194 613.0
MMD2_k127_5207862_1 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 318.0
MMD2_k127_5207862_2 Peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.00000000000000000000000000000007862 126.0
MMD2_k127_5207862_3 ACT domain - - - 0.0000000000000000000000176 108.0
MMD2_k127_5221687_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 468.0
MMD2_k127_5221687_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00001261 54.0
MMD2_k127_5229964_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 563.0
MMD2_k127_5229964_1 PFAM peptidase U62 modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005287 282.0
MMD2_k127_5229964_2 Abc transporter K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000005056 197.0
MMD2_k127_5229964_3 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000006624 100.0
MMD2_k127_5229964_4 ABC-2 type transporter K01992 - - 0.000004625 57.0
MMD2_k127_5239299_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000002067 94.0
MMD2_k127_5239299_1 PFAM Amino acid-binding ACT - - - 0.00000000001578 70.0
MMD2_k127_5239299_2 GAF domain - - - 0.000000005121 62.0
MMD2_k127_5239299_3 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000004655 54.0
MMD2_k127_5239299_4 Protein of unknown function (DUF424) K09148 - - 0.00001565 51.0
MMD2_k127_5273570_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 334.0
MMD2_k127_5273570_1 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 319.0
MMD2_k127_5273570_2 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 306.0
MMD2_k127_5273570_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001135 282.0
MMD2_k127_5273570_4 PFAM Bacterial protein of K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005365 265.0
MMD2_k127_5273570_5 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000005254 156.0
MMD2_k127_5273570_6 ribulose-phosphate 3-epimerase activity K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0030246,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046983,GO:0048029,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000003982 149.0
MMD2_k127_5273570_7 E3 Ubiquitin ligase - - - 0.00000000007852 70.0
MMD2_k127_5325202_0 Deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 522.0
MMD2_k127_5325202_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K00836 - 2.6.1.19,2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 351.0
MMD2_k127_5325202_2 Flavin reductase like domain - - - 0.0000000000000000000000000004672 119.0
MMD2_k127_5325202_3 Transglutaminase-like superfamily - - - 0.000791 51.0
MMD2_k127_53544_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 6.497e-203 651.0
MMD2_k127_53544_1 ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 478.0
MMD2_k127_53544_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 0.0000000000000000000000000000000009395 134.0
MMD2_k127_53544_3 diguanylate cyclase - - - 0.00000000000000000000000001298 120.0
MMD2_k127_53544_4 methyltransferase activity K00569 - 2.1.1.67 0.000000000000000002973 92.0
MMD2_k127_53544_5 CBS domain - - - 0.0000000000000001646 91.0
MMD2_k127_53544_6 Segregation and condensation protein ScpA K05896 - - 0.00000000000000108 86.0
MMD2_k127_53544_7 Pfam:DUF552 K09152 - - 0.000003731 55.0
MMD2_k127_536704_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.062e-202 661.0
MMD2_k127_536704_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000001168 249.0
MMD2_k127_536704_2 Ankyrin repeat protein K06867 - - 0.0004016 49.0
MMD2_k127_5372633_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.287e-201 643.0
MMD2_k127_5372633_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 535.0
MMD2_k127_5372633_2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765 2.1.1.98 0.00000000000000000000000000000000000000000006187 168.0
MMD2_k127_5372633_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000003856 102.0
MMD2_k127_5372633_4 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000007636 90.0
MMD2_k127_5377417_0 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000009103 162.0
MMD2_k127_5377417_1 Ribosomal S13/S15 N-terminal domain K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001642 140.0
MMD2_k127_5377417_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000001012 117.0
MMD2_k127_5377417_3 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000005088 97.0
MMD2_k127_5377417_4 AsnC family K03719 - - 0.00000000000476 72.0
MMD2_k127_5377417_5 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000221 58.0
MMD2_k127_5377417_6 Xylose isomerase domain protein TIM barrel - - - 0.0001554 54.0
MMD2_k127_5422694_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 306.0
MMD2_k127_5422694_1 TspO/MBR family K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000001257 179.0
MMD2_k127_550514_0 Magnesium chelatase, subunit ChlI K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 472.0
MMD2_k127_550514_1 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000752 209.0
MMD2_k127_550514_2 ERCC4 domain K10896 - - 0.000000000000000000000000000000000000007254 153.0
MMD2_k127_550514_3 Exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000206 160.0
MMD2_k127_550514_4 Transcriptional regulator K07729 - - 0.0000000000004474 72.0
MMD2_k127_5534340_0 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002747 293.0
MMD2_k127_5534340_1 PFAM zinc iron permease K16267 - - 0.0000000000000000000000000000000000000000000000000000000183 206.0
MMD2_k127_5534340_2 PFAM FecR protein - - - 0.0000000000004377 75.0
MMD2_k127_5534340_3 Pkd domain containing protein - - - 0.0005166 53.0
MMD2_k127_5548595_0 dna ligase K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 509.0
MMD2_k127_5548595_1 metallopeptidase activity - - - 0.0001049 53.0
MMD2_k127_5586480_0 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000002294 114.0
MMD2_k127_5586480_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001604 108.0
MMD2_k127_5586480_2 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000003471 103.0
MMD2_k127_5586480_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000008614 91.0
MMD2_k127_5646514_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 336.0
MMD2_k127_5646514_1 PFAM helix-turn-helix domain protein K03627 - - 0.00001032 50.0
MMD2_k127_5694018_0 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001202 276.0
MMD2_k127_5694018_1 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000003424 208.0
MMD2_k127_5717432_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 467.0
MMD2_k127_5717432_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000001488 245.0
MMD2_k127_5717432_2 PFAM glycosyl transferase group 1 K19002 - 2.4.1.337 0.00000000000000000000000000000000000000000000000001038 197.0
MMD2_k127_5717432_3 - - - - 0.000000000000000000000000000000006616 128.0
MMD2_k127_5717432_4 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.0000000000000000000000000008982 116.0
MMD2_k127_5717432_5 - - - - 0.0002532 48.0
MMD2_k127_5736531_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 361.0
MMD2_k127_5736531_1 Nitroreductase family - - - 0.00000000000000000000000000000000000000000006826 166.0
MMD2_k127_5736531_2 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000001202 163.0
MMD2_k127_5736531_3 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.000000000000000000005684 95.0
MMD2_k127_5736531_4 thiolester hydrolase activity - - - 0.0000004864 61.0
MMD2_k127_5736531_5 Protein of unknown function (DUF357) K09728 - - 0.00007285 51.0
MMD2_k127_5768002_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002663 284.0
MMD2_k127_5768002_1 Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000002402 145.0
MMD2_k127_5771377_0 KaiC K08482 - - 0.000001929 56.0
MMD2_k127_5771377_1 dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0006758 51.0
MMD2_k127_5781244_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 503.0
MMD2_k127_5781244_1 Major facilitator superfamily K08161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005061 284.0
MMD2_k127_5781244_2 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000002065 215.0
MMD2_k127_5781244_3 ATP cob(I)alamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000001868 178.0
MMD2_k127_5781244_4 Predicted membrane protein (DUF2207) - - - 0.000000001717 69.0
MMD2_k127_5781244_5 negative regulation of heat generation - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0019899,GO:0019902,GO:0019903,GO:0030346,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0060255,GO:0065007 - 0.00007461 51.0
MMD2_k127_585237_0 Belongs to the UPF0219 family K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004877 471.0
MMD2_k127_585237_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 436.0
MMD2_k127_585237_2 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000003783 237.0
MMD2_k127_585237_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000003025 228.0
MMD2_k127_585237_4 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.0000000000000000000000000000001473 136.0
MMD2_k127_5901607_0 SMART phospholipase D Transphosphatidylase - - - 0.00000000000004664 79.0
MMD2_k127_5901607_1 ATPase, AAA superfamily - - - 0.00000002263 65.0
MMD2_k127_5911295_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000002775 149.0
MMD2_k127_5911295_1 Translin family K07477 - - 0.00000000000000000000005529 105.0
MMD2_k127_5911295_2 ACT domain K09964 - - 0.00000000000000000002378 96.0
MMD2_k127_5911295_3 PFAM elongation factor Tu domain 2 - - - 0.0000000000000004237 87.0
MMD2_k127_5911295_4 Pkd domain containing protein - - - 0.00003071 57.0
MMD2_k127_5915034_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 400.0
MMD2_k127_5920748_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 429.0
MMD2_k127_5920748_1 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000001091 254.0
MMD2_k127_5920748_10 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000002568 61.0
MMD2_k127_5920748_11 ACT domain protein - - - 0.00006582 50.0
MMD2_k127_5920748_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000005601 220.0
MMD2_k127_5920748_3 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.0000000000000000000000000000000000000000000000000000000003706 209.0
MMD2_k127_5920748_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.00000000000000000000000000000000000002108 153.0
MMD2_k127_5920748_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000002594 136.0
MMD2_k127_5920748_7 DHH family - - - 0.000000000000000000000004994 113.0
MMD2_k127_5920748_8 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000004222 60.0
MMD2_k127_5920748_9 structural constituent of ribosome K02921,K07374,K14566,K20241 GO:0000184,GO:0000956,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006413,GO:0006518,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015031,GO:0015833,GO:0015934,GO:0016070,GO:0016071,GO:0019222,GO:0019439,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0034641,GO:0034645,GO:0034655,GO:0042886,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045047,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048519,GO:0050789,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060255,GO:0065007,GO:0070180,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1990904 - 0.00000004443 58.0
MMD2_k127_5944787_0 Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 494.0
MMD2_k127_5944787_1 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 295.0
MMD2_k127_5944787_2 uridine kinase K00876 - 2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000008048 257.0
MMD2_k127_5983738_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 389.0
MMD2_k127_5983738_1 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000001212 229.0
MMD2_k127_5983738_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000001007 159.0
MMD2_k127_6001736_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 460.0
MMD2_k127_6001736_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 354.0
MMD2_k127_6001736_2 phosphoribosyltransferases - - - 0.0000000000000000000000000000000000000000000006633 173.0
MMD2_k127_6001736_3 Major facilitator Superfamily - - - 0.0000000009042 70.0
MMD2_k127_6001736_4 Putative zinc- or iron-chelating domain K06940 - - 0.00000001214 63.0
MMD2_k127_6001736_5 Worm-specific repeat type 1 - GO:0002009,GO:0002165,GO:0003674,GO:0005198,GO:0005201,GO:0005575,GO:0005576,GO:0007275,GO:0007424,GO:0007444,GO:0007472,GO:0007475,GO:0007476,GO:0007552,GO:0007560,GO:0007591,GO:0008150,GO:0008362,GO:0008587,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0022404,GO:0031012,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040003,GO:0040005,GO:0042303,GO:0042335,GO:0044421,GO:0044719,GO:0048513,GO:0048563,GO:0048569,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0060429,GO:0060541,GO:0060562,GO:0065007,GO:0065008,GO:0090066 - 0.00009656 54.0
MMD2_k127_6049065_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002349 286.0
MMD2_k127_6049065_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000000007393 181.0
MMD2_k127_6049065_2 KaiC - - - 0.0000000000000000000000000002285 127.0
MMD2_k127_6049065_3 PFAM Metallophosphoesterase K07096 - - 0.00000000000000000000000007777 116.0
MMD2_k127_6049065_4 - - - - 0.0000000001073 74.0
MMD2_k127_6049065_5 acetyltransferase K00657,K09962 - 2.3.1.57 0.000005084 54.0
MMD2_k127_6049065_6 Histidine biosynthesis protein K01814,K01817 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 0.0003633 50.0
MMD2_k127_606499_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000004674 247.0
MMD2_k127_6075091_0 type II secretion K07333 - - 0.000000000000003124 86.0
MMD2_k127_608429_0 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000207 139.0
MMD2_k127_608429_1 endonuclease III K07457 - - 0.00000000000000000000000000000002357 130.0
MMD2_k127_608429_2 DnaJ-class molecular chaperone with C-terminal Zn finger domain K05516 - - 0.000000000000000001779 98.0
MMD2_k127_6086125_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.817e-275 869.0
MMD2_k127_6086125_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.039e-246 777.0
MMD2_k127_6086125_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000002126 219.0
MMD2_k127_6086125_3 - - - - 0.000000000000000000000000000000000000000000000000009566 186.0
MMD2_k127_6086125_4 Beta-Casp domain K07577 - - 0.000000000000000000000000000000000000000000000002402 180.0
MMD2_k127_6090494_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 394.0
MMD2_k127_6090494_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 362.0
MMD2_k127_6090494_2 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006964 279.0
MMD2_k127_6090494_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000012 169.0
MMD2_k127_6090494_4 - - - - 0.0000000000000000000000000000000000000000009744 166.0
MMD2_k127_6090494_5 Belongs to the universal ribosomal protein uL16 family K02866 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000538 131.0
MMD2_k127_6090494_6 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000006983 134.0
MMD2_k127_6090494_7 COG0666 FOG Ankyrin repeat K06867 - - 0.000000000000000000000001299 111.0
MMD2_k127_6090494_8 PFAM Protein kinase K08884,K12132 - 2.7.11.1 0.0000004655 57.0
MMD2_k127_6099303_0 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000004691 197.0
MMD2_k127_6100745_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 460.0
MMD2_k127_6100745_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000007675 54.0
MMD2_k127_616199_0 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002844 267.0
MMD2_k127_616199_1 phosphoribosylamine-glycine ligase activity K01945,K01955 - 6.3.4.13,6.3.5.5 0.0000000000000000000000000000000000000000000002882 170.0
MMD2_k127_616199_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000005527 164.0
MMD2_k127_616199_3 Hydrolases of the alpha beta superfamily K06889,K07397 - - 0.00000000000000000000000000000000000001836 153.0
MMD2_k127_616199_4 Integral membrane protein DUF92 - - - 0.000000000000000000000000000002451 128.0
MMD2_k127_616199_5 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000007082 108.0
MMD2_k127_616199_6 Probable zinc-ribbon domain K03704 - - 0.0000000000007607 68.0
MMD2_k127_616199_7 PBS lyase HEAT-like repeat - - - 0.0000000000174 78.0
MMD2_k127_616199_8 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K00966,K16881 - 2.7.7.13,5.4.2.8 0.0000000009289 61.0
MMD2_k127_616199_9 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.000004737 57.0
MMD2_k127_6193234_0 Belongs to the MCM family K10726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 512.0
MMD2_k127_6193234_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 353.0
MMD2_k127_6193234_2 Met-10+ like-protein K15429 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001217 289.0
MMD2_k127_6193234_3 Type II secretion system K07333 - - 0.00000000000002943 83.0
MMD2_k127_6193234_4 Presenilin, signal peptide peptidase, family - - - 0.000000002279 68.0
MMD2_k127_6193234_5 Haloacid dehalogenase-like hydrolase - - - 0.0001025 53.0
MMD2_k127_6236291_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 - - 0.000000000000000000000000000000000000000000000000000000000000000000003185 246.0
MMD2_k127_6236291_1 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000003944 146.0
MMD2_k127_6236291_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000003655 141.0
MMD2_k127_6236291_3 HIT domain K02503 - - 0.00000000000000000000000000000009247 131.0
MMD2_k127_6236291_4 Pfam:Nol1_Nop2_Fmu_2 - - - 0.000000002709 64.0
MMD2_k127_623712_0 Restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000002227 216.0
MMD2_k127_623712_1 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000005367 168.0
MMD2_k127_623712_2 AAA ATPase domain - - - 0.0000000000000000000000000000000000663 147.0
MMD2_k127_6238795_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000926 143.0
MMD2_k127_6238795_1 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000005902 115.0
MMD2_k127_6257240_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 391.0
MMD2_k127_6257240_1 Cysteinyl-tRNA synthetase K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 288.0
MMD2_k127_6257240_2 Domain of unknown function (DUF4870) - - - 0.00000001096 61.0
MMD2_k127_648334_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 3.589e-271 852.0
MMD2_k127_648334_1 PFAM Peptidase - - - 0.000000000000000000000000005169 117.0
MMD2_k127_651974_0 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000000000000000004533 205.0
MMD2_k127_651974_1 PFAM ribonuclease H K03469,K06864 - 3.1.26.4 0.000000000000000000000000000000002284 133.0
MMD2_k127_651974_2 Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.000000001998 65.0
MMD2_k127_651974_3 membrane K08981 - - 0.0000005211 57.0
MMD2_k127_67162_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008178 499.0
MMD2_k127_67162_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000003091 241.0
MMD2_k127_67162_2 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000006677 227.0
MMD2_k127_67162_3 Transcriptional regulator, XRE family - - - 0.00000000000000000000000000000000006014 140.0
MMD2_k127_67162_4 AN1-like Zinc finger K07059 - - 0.000000000000000000000000001222 120.0
MMD2_k127_67162_5 PDZ DHR GLGF domain protein K04771 - 3.4.21.107 0.000000000000000000001593 106.0
MMD2_k127_67162_6 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.000000000000001695 87.0
MMD2_k127_67162_7 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000006477 77.0
MMD2_k127_67162_8 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00008898 53.0
MMD2_k127_711722_0 Hemerythrin HHE cation binding domain - - - 0.0000000000000001616 86.0
MMD2_k127_711722_1 DNA repair K10865 - - 0.00000000000005884 83.0
MMD2_k127_711722_2 Alpha/beta hydrolase family - - - 0.00002397 49.0
MMD2_k127_74318_0 PFAM Fibronectin-binding A - - - 0.00000000000000000000000000000000000004014 156.0
MMD2_k127_74318_1 PFAM periplasmic copper-binding - - - 0.0000001992 65.0
MMD2_k127_74318_2 Heparan-alpha-glucosaminide N-acetyltransferase-like K09872,K10532 - 2.3.1.78 0.0002018 52.0
MMD2_k127_8042_0 dCMP deaminase activity K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000005203 208.0
MMD2_k127_8042_1 dephospho-CoA kinase activity - - - 0.00000000000000000000000000000000004702 147.0
MMD2_k127_805725_0 Lipopolysaccharide kinase (Kdo/WaaP) family K08884,K12132 - 2.7.11.1 0.00000000001528 75.0
MMD2_k127_805725_1 protein kinase activity K12132 - 2.7.11.1 0.00007388 50.0
MMD2_k127_831003_0 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 310.0
MMD2_k127_831003_1 ribosylpyrimidine nucleosidase activity - - - 0.00000000000000001447 91.0
MMD2_k127_831003_2 Inosine-uridine preferring nucleoside hydrolase K01239 - 3.2.2.1 0.000000000000005787 87.0
MMD2_k127_857840_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000005077 180.0
MMD2_k127_857840_1 COG0644 Dehydrogenases (flavoproteins) - - - 0.0000000000000000000000000000001576 137.0
MMD2_k127_857840_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000004912 104.0
MMD2_k127_857840_3 4Fe-4S binding domain - - - 0.000000004753 60.0
MMD2_k127_89613_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 377.0
MMD2_k127_89613_1 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001465 293.0
MMD2_k127_89613_2 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000003968 231.0
MMD2_k127_89613_3 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.0001951 44.0
MMD2_k127_902925_0 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 6.825e-200 636.0
MMD2_k127_902925_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 388.0
MMD2_k127_902925_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 329.0
MMD2_k127_902925_3 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000004708 104.0
MMD2_k127_957793_0 Nitroreductase family K04719 - 1.13.11.79 0.00000000002011 68.0