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Overview

ID MAG02375
Name MMD2_bin.6
Sample SMP0059
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JACTUA01
Species
Assembly information
Completeness (%) 87.8
Contamination (%) 0.59
GC content (%) 65.0
N50 (bp) 9,589
Genome size (bp) 1,543,160

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1656

Gene name Description KEGG GOs EC E-value Score Sequence
MMD2_k127_1009708_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 317.0
MMD2_k127_1029212_0 Heat shock 70 kDa protein K04043 - - 2.474e-262 814.0
MMD2_k127_1029212_1 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 442.0
MMD2_k127_1029212_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 441.0
MMD2_k127_1029212_3 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 346.0
MMD2_k127_1029212_4 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001717 212.0
MMD2_k127_1029212_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000003882 154.0
MMD2_k127_1029212_6 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000000000002103 138.0
MMD2_k127_1029273_0 Radical SAM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 394.0
MMD2_k127_1029273_1 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000009485 82.0
MMD2_k127_1029273_2 - - - - 0.00000000000001044 81.0
MMD2_k127_1029273_3 Domain of unknown function (DUF3821) - - - 0.00000000000005111 81.0
MMD2_k127_1042267_0 Domain of unknown function (DUF1848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 302.0
MMD2_k127_1057939_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.067e-248 772.0
MMD2_k127_1057939_1 TIGRFAM ribosomal protein L30P K02907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001122 261.0
MMD2_k127_1057939_2 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000007461 158.0
MMD2_k127_1057939_3 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000001516 67.0
MMD2_k127_1070609_0 PFAM SufBD protein K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 563.0
MMD2_k127_1070609_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 511.0
MMD2_k127_1070609_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 511.0
MMD2_k127_1070609_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 471.0
MMD2_k127_1070609_4 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 469.0
MMD2_k127_1070609_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000001205 276.0
MMD2_k127_1070609_6 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004794 262.0
MMD2_k127_1070609_7 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000007682 199.0
MMD2_k127_1070609_8 PFAM cyclase family protein K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000001072 196.0
MMD2_k127_1070609_9 - - - - 0.00000000000000000000000000000000000000000001124 175.0
MMD2_k127_1078069_0 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000000337 190.0
MMD2_k127_1078069_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000002202 110.0
MMD2_k127_1078069_2 PBS lyase K22221 - - 0.00000004464 64.0
MMD2_k127_1227020_0 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 304.0
MMD2_k127_1227020_1 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 308.0
MMD2_k127_1227020_2 membrane protein (DUF2178) - - - 0.0000000000000000000000000000000000000000000000000000000000003517 216.0
MMD2_k127_1227020_3 Transcriptional K07729 - - 0.00000000000001168 76.0
MMD2_k127_1233156_0 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004224 278.0
MMD2_k127_1233156_1 - - - - 0.0000000000000000000000002129 109.0
MMD2_k127_1262464_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 5.811e-233 739.0
MMD2_k127_1262464_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000899 328.0
MMD2_k127_1262464_10 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000000000000000000007966 130.0
MMD2_k127_1262464_12 SigmaK-factor processing regulatory protein BofA K06317 - - 0.0000000000007203 71.0
MMD2_k127_1262464_2 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 307.0
MMD2_k127_1262464_3 Lon protease (S16) C-terminal proteolytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001185 282.0
MMD2_k127_1262464_4 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000003493 224.0
MMD2_k127_1262464_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000004419 205.0
MMD2_k127_1262464_6 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000001074 213.0
MMD2_k127_1262464_7 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.0000000000000000000000000000000000000000000000000000000001371 208.0
MMD2_k127_1262464_8 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000001499 192.0
MMD2_k127_1262464_9 Thioredoxin - - - 0.0000000000000000000000000000000000000000004492 160.0
MMD2_k127_1375154_0 PFAM ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 458.0
MMD2_k127_1402400_0 DEAD DEAH box helicase domain protein K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 616.0
MMD2_k127_1402400_1 PFAM metallophosphoesterase K06953 - - 0.0000000001388 64.0
MMD2_k127_1511060_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 359.0
MMD2_k127_1511060_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000007132 147.0
MMD2_k127_1511060_2 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000000003028 142.0
MMD2_k127_1511060_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0000000000000000000252 90.0
MMD2_k127_1511060_4 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000006384 83.0
MMD2_k127_1511060_5 Probably involved in the biogenesis of the ribosome K14561 - - 0.000000000000001145 83.0
MMD2_k127_1517989_0 Domain of unknown function (DUF814) - - - 5.161e-215 685.0
MMD2_k127_1517989_1 in RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 484.0
MMD2_k127_1517989_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 406.0
MMD2_k127_1517989_3 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 369.0
MMD2_k127_1517989_4 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 287.0
MMD2_k127_1517989_5 RNase L inhibitor, RLI - - - 0.000000000000000000000000002522 115.0
MMD2_k127_1517989_6 AMP-binding enzyme - - - 0.000000000000000000000000006118 112.0
MMD2_k127_1517989_7 Psort location CytoplasmicMembrane, score 10.00 K03975 - - 0.00000000000000000000000001069 118.0
MMD2_k127_1517989_8 phosphatase K14165 - 3.1.3.16,3.1.3.48 0.00000000000000000000105 101.0
MMD2_k127_1552673_0 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 324.0
MMD2_k127_1552673_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006861 310.0
MMD2_k127_1552673_2 Sugar efflux transporter for intercellular exchange K15383 - - 0.0000000000000001387 92.0
MMD2_k127_1574555_0 PFAM type II secretion system protein E K07332 - - 8.161e-283 880.0
MMD2_k127_1574555_1 in RNase L inhibitor, RLI K06174 - - 1.935e-210 662.0
MMD2_k127_1574555_10 Archaeal flagellar protein F K07329 - - 0.0000000000000000000004577 101.0
MMD2_k127_1574555_2 type II secretion system protein K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 554.0
MMD2_k127_1574555_3 KaiC K07331 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 319.0
MMD2_k127_1574555_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 321.0
MMD2_k127_1574555_5 - - - - 0.00000000000000000000000000000000000000000000000000000001099 214.0
MMD2_k127_1574555_6 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07324,K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000000000000002995 173.0
MMD2_k127_1574555_7 - - - - 0.000000000000000000000000000000000000000000001909 174.0
MMD2_k127_1574555_8 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07324,K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000000000008319 163.0
MMD2_k127_1574555_9 Archaebacterial flagellin K07330 - - 0.00000000000000000000000000000000004305 139.0
MMD2_k127_1576858_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 298.0
MMD2_k127_1576858_1 WxcM-like, C-terminal K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000005182 208.0
MMD2_k127_1576858_2 PFAM NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.00000000000000001831 88.0
MMD2_k127_16578_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 402.0
MMD2_k127_16578_1 Domain of unknown function (DUF1917) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 286.0
MMD2_k127_16578_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000107 254.0
MMD2_k127_16578_3 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000004075 258.0
MMD2_k127_16578_4 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000002519 226.0
MMD2_k127_16578_5 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000002331 81.0
MMD2_k127_16578_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000001791 50.0
MMD2_k127_1703431_0 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000005331 230.0
MMD2_k127_1703431_1 Male sterility protein K01710,K08678,K21211 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000002728 203.0
MMD2_k127_1703431_2 Methyltransferase domain - - - 0.00000000000000000000000000004459 121.0
MMD2_k127_1703431_3 transferase hexapeptide repeat K00633 - 2.3.1.18 0.000000000000000000000000006687 116.0
MMD2_k127_1703431_4 cyclase family - - - 0.00000000000000000008156 98.0
MMD2_k127_1707988_0 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 346.0
MMD2_k127_1707988_1 AIR synthase related protein domain protein K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 310.0
MMD2_k127_1707988_2 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001564 272.0
MMD2_k127_1707988_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000138 273.0
MMD2_k127_1707988_4 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003092 263.0
MMD2_k127_1712664_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 562.0
MMD2_k127_1712664_1 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 514.0
MMD2_k127_1712664_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 344.0
MMD2_k127_1712664_3 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005669 272.0
MMD2_k127_1712664_4 - - - - 0.0000000000000000000000000000000000000000005723 169.0
MMD2_k127_1712664_5 peptidyl-tyrosine sulfation - - - 0.000000005299 62.0
MMD2_k127_175566_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 3.297e-250 788.0
MMD2_k127_175566_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 553.0
MMD2_k127_175566_2 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 517.0
MMD2_k127_175566_3 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 367.0
MMD2_k127_175566_4 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 287.0
MMD2_k127_175566_5 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001688 243.0
MMD2_k127_175566_6 PFAM ribonuclease II K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000007307 198.0
MMD2_k127_175566_7 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000000000005429 174.0
MMD2_k127_175566_8 Family of unknown function (DUF5350) - - - 0.000000000000000000001651 104.0
MMD2_k127_175566_9 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000000008315 98.0
MMD2_k127_181285_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 2.459e-199 626.0
MMD2_k127_181285_1 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 550.0
MMD2_k127_181285_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 286.0
MMD2_k127_181285_3 LysM domain - - - 0.00000000000000000000000000000000000000000004274 177.0
MMD2_k127_181285_4 LysM domain - - - 0.00000000000000000000000000000000000000000996 170.0
MMD2_k127_1813926_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1153.0
MMD2_k127_1813926_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 3.326e-318 994.0
MMD2_k127_1813926_10 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000002956 126.0
MMD2_k127_1813926_11 Pas domain - - - 0.000000000000000000000000002207 132.0
MMD2_k127_1813926_12 metallopeptidase activity - - - 0.00000000000000000003706 96.0
MMD2_k127_1813926_13 PFAM TPR repeat-containing protein - - - 0.0000000000007098 74.0
MMD2_k127_1813926_14 TRANSCRIPTIONal - - - 0.00000000007797 67.0
MMD2_k127_1813926_2 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 1.641e-195 617.0
MMD2_k127_1813926_3 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 585.0
MMD2_k127_1813926_4 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 403.0
MMD2_k127_1813926_5 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 291.0
MMD2_k127_1813926_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003127 312.0
MMD2_k127_1813926_7 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.00000000000000000000000000000000000000000000000005156 199.0
MMD2_k127_1813926_8 - - - - 0.000000000000000000000000000000001144 136.0
MMD2_k127_1813926_9 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000006616 135.0
MMD2_k127_1871507_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1334.0
MMD2_k127_1871507_1 PFAM PilT protein domain protein K06865 - - 1.838e-276 862.0
MMD2_k127_1871507_10 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000148 152.0
MMD2_k127_1871507_11 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000004555 138.0
MMD2_k127_1871507_12 - - - - 0.0000691 53.0
MMD2_k127_1871507_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 5.175e-197 636.0
MMD2_k127_1871507_3 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 524.0
MMD2_k127_1871507_4 TIGRFAM cell division ATPase MinD K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 376.0
MMD2_k127_1871507_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 291.0
MMD2_k127_1871507_6 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000000000000000000000001458 248.0
MMD2_k127_1871507_7 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000001555 188.0
MMD2_k127_1871507_8 - - - - 0.00000000000000000000000000000000000000000000000003791 186.0
MMD2_k127_1871507_9 Roadblock LC7 K07131 - - 0.00000000000000000000000000000000000000000000000005053 179.0
MMD2_k127_1876315_0 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000892 512.0
MMD2_k127_1876315_1 involved in cell wall biogenesis K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 363.0
MMD2_k127_1876315_2 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000004751 186.0
MMD2_k127_1876315_3 glycosyl transferase, family 39 - - - 0.0004185 44.0
MMD2_k127_1880803_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 452.0
MMD2_k127_1927871_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1249.0
MMD2_k127_1927871_1 Protein of unknown function (DUF1646) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 430.0
MMD2_k127_1927871_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003683 276.0
MMD2_k127_1927871_3 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000002945 193.0
MMD2_k127_1927871_4 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000001736 156.0
MMD2_k127_1927871_5 Rubrerythrin - - - 0.00000000000000000000000000000000000001257 148.0
MMD2_k127_1927871_6 zinc finger, SWIM - - - 0.00000000000000000000000000004725 126.0
MMD2_k127_1934578_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 9.199e-201 632.0
MMD2_k127_1947393_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 598.0
MMD2_k127_1947393_1 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 451.0
MMD2_k127_1947393_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 415.0
MMD2_k127_1947393_3 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 402.0
MMD2_k127_1947393_4 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 308.0
MMD2_k127_1947393_5 - - - - 0.000000000000000000000000000001887 121.0
MMD2_k127_1982121_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008379 544.0
MMD2_k127_1982121_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001535 249.0
MMD2_k127_1982121_2 - - - - 0.0000000000000000000000000000000000000000001531 165.0
MMD2_k127_1982121_3 Glyoxalase-like domain K06996 - - 0.0000005539 52.0
MMD2_k127_2000808_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 571.0
MMD2_k127_2000808_1 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 465.0
MMD2_k127_2000808_2 PFAM metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 289.0
MMD2_k127_2000808_3 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000007396 146.0
MMD2_k127_2000808_4 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000003205 142.0
MMD2_k127_2013184_0 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 4.742e-271 837.0
MMD2_k127_2013184_1 TIGRFAM cell division ATPase MinD K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 347.0
MMD2_k127_2013184_2 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 304.0
MMD2_k127_2013184_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000000000000005272 128.0
MMD2_k127_2013184_4 Phosphate-starvation-inducible E - - - 0.00000000000000000000000001824 116.0
MMD2_k127_2013184_5 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.000000000000000000001232 94.0
MMD2_k127_2013184_6 - - - - 0.00000000000001696 81.0
MMD2_k127_2013184_7 - - - - 0.0000000000001234 81.0
MMD2_k127_2097828_0 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 550.0
MMD2_k127_2097828_1 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 359.0
MMD2_k127_2097828_2 Involved in protein export K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 317.0
MMD2_k127_2097828_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000342 289.0
MMD2_k127_2097828_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.00000000000000000000000000000000001194 139.0
MMD2_k127_2097828_5 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000001203 118.0
MMD2_k127_2097828_6 - - - - 0.000000000000000000000001331 107.0
MMD2_k127_2097828_7 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000001496 78.0
MMD2_k127_2124856_0 DEAD DEAH box helicase domain protein K10896 - - 8.556e-307 973.0
MMD2_k127_2124856_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.836e-267 833.0
MMD2_k127_2124856_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 311.0
MMD2_k127_2124856_3 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 311.0
MMD2_k127_2124856_4 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000005371 204.0
MMD2_k127_2124856_5 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000008704 147.0
MMD2_k127_2124856_6 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000003099 80.0
MMD2_k127_2124856_7 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.000000000000007633 81.0
MMD2_k127_2144408_0 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000006506 216.0
MMD2_k127_2144408_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000002913 93.0
MMD2_k127_2204081_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 4.913e-303 940.0
MMD2_k127_2204081_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 4.87e-200 629.0
MMD2_k127_2204081_2 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 610.0
MMD2_k127_2204081_3 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 575.0
MMD2_k127_2204081_4 Helix-turn-helix domain protein K03627 - - 0.000000000693 71.0
MMD2_k127_2224691_0 FHA domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000697 250.0
MMD2_k127_2287230_0 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000005602 229.0
MMD2_k127_2287230_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000001804 115.0
MMD2_k127_2287230_2 nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000000009092 125.0
MMD2_k127_2287230_3 PFAM Telomeric repeat-binding factor 2 - - - 0.000000000000000009754 89.0
MMD2_k127_2296821_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 455.0
MMD2_k127_2296821_1 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 404.0
MMD2_k127_2296821_2 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.0000000000000000000000000000000000000000000000000006314 187.0
MMD2_k127_2296821_3 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000001432 172.0
MMD2_k127_2296821_4 SpoVT / AbrB like domain - - - 0.00000000000000000000000006402 109.0
MMD2_k127_2298460_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 572.0
MMD2_k127_2298460_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 463.0
MMD2_k127_2298460_2 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 424.0
MMD2_k127_2298460_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 396.0
MMD2_k127_2298460_4 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001061 258.0
MMD2_k127_2308539_0 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 448.0
MMD2_k127_2308539_1 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 376.0
MMD2_k127_2308539_2 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 355.0
MMD2_k127_2308539_3 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 332.0
MMD2_k127_2308539_4 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001024 278.0
MMD2_k127_2308539_5 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000254 241.0
MMD2_k127_2318658_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005433 597.0
MMD2_k127_2318658_1 transcriptional K07729 - - 0.000000000000000000001051 96.0
MMD2_k127_2318658_2 Class III signal peptide - - - 0.000001665 54.0
MMD2_k127_2318658_3 - - - - 0.000009944 49.0
MMD2_k127_2324274_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 2.426e-311 962.0
MMD2_k127_2324274_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 8.317e-267 826.0
MMD2_k127_2324274_10 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000000009668 79.0
MMD2_k127_2324274_11 - - - - 0.000000000001874 74.0
MMD2_k127_2324274_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 558.0
MMD2_k127_2324274_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 523.0
MMD2_k127_2324274_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007815 377.0
MMD2_k127_2324274_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 297.0
MMD2_k127_2324274_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000000000001479 177.0
MMD2_k127_2324274_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000000997 147.0
MMD2_k127_2324274_8 Winged helix-turn-helix - - - 0.000000000000000000000000000000000001594 139.0
MMD2_k127_2324274_9 YCII-related domain - - - 0.00000000000000000000004124 101.0
MMD2_k127_2349296_0 amino acid K03294 - - 2.211e-287 895.0
MMD2_k127_2349296_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 3.433e-194 614.0
MMD2_k127_2349296_10 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005001 262.0
MMD2_k127_2349296_11 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001649 250.0
MMD2_k127_2349296_12 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000005673 226.0
MMD2_k127_2349296_13 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000001052 226.0
MMD2_k127_2349296_14 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000005447 211.0
MMD2_k127_2349296_15 PFAM PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000000000000000000003405 203.0
MMD2_k127_2349296_16 metallopeptidase activity - - - 0.000000000000000000000000000000000000002693 150.0
MMD2_k127_2349296_17 Domain of unknown function (DUF1805) - - - 0.0000000000000000000000000000002465 126.0
MMD2_k127_2349296_18 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000003141 91.0
MMD2_k127_2349296_19 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000005583 89.0
MMD2_k127_2349296_2 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 530.0
MMD2_k127_2349296_20 STAS domain K04749 - - 0.00000000000000222 81.0
MMD2_k127_2349296_3 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 480.0
MMD2_k127_2349296_4 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 457.0
MMD2_k127_2349296_5 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008517 449.0
MMD2_k127_2349296_6 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 409.0
MMD2_k127_2349296_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 376.0
MMD2_k127_2349296_8 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 331.0
MMD2_k127_2349296_9 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 293.0
MMD2_k127_2380921_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1257.0
MMD2_k127_2380921_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 3.039e-257 806.0
MMD2_k127_2380921_10 - - - - 0.00000000000000000000000000000000000000005282 153.0
MMD2_k127_2380921_11 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000002053 155.0
MMD2_k127_2380921_12 - - - - 0.0000000000000000000000001845 111.0
MMD2_k127_2380921_13 Group 1 family - - - 0.00000000000000436 79.0
MMD2_k127_2380921_14 - - - - 0.00000000000468 70.0
MMD2_k127_2380921_15 TGS domain protein K06942 - - 0.0005723 46.0
MMD2_k127_2380921_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.261e-218 688.0
MMD2_k127_2380921_3 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 535.0
MMD2_k127_2380921_4 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000979 376.0
MMD2_k127_2380921_5 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 322.0
MMD2_k127_2380921_6 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 283.0
MMD2_k127_2380921_7 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000003012 241.0
MMD2_k127_2380921_8 PFAM Conserved TM helix repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000004876 197.0
MMD2_k127_2380921_9 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000005438 177.0
MMD2_k127_2381955_0 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 342.0
MMD2_k127_2381955_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000001345 177.0
MMD2_k127_2383491_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 509.0
MMD2_k127_2383491_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 419.0
MMD2_k127_2383491_2 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 373.0
MMD2_k127_2383491_3 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 345.0
MMD2_k127_2383491_4 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 312.0
MMD2_k127_2383491_5 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006924 253.0
MMD2_k127_2383491_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000006375 80.0
MMD2_k127_2395717_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 3.109e-217 685.0
MMD2_k127_2395717_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 1.255e-201 642.0
MMD2_k127_2395717_2 PFAM Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 572.0
MMD2_k127_2395717_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006361 368.0
MMD2_k127_2395717_4 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 364.0
MMD2_k127_2395717_5 - - - - 0.00000000000000000000000000000000000000000000000000261 191.0
MMD2_k127_2395717_6 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000001516 181.0
MMD2_k127_2395717_7 HEAT repeats - - - 0.0000000000000000000000002152 114.0
MMD2_k127_2396342_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.112e-269 841.0
MMD2_k127_2396342_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 584.0
MMD2_k127_2396342_10 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000003154 262.0
MMD2_k127_2396342_11 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000001627 254.0
MMD2_k127_2396342_12 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.000000000000000000000000000000000000000000000000000000000001698 214.0
MMD2_k127_2396342_13 - - - - 0.000000000000000000000000000000000000000000000000000007296 195.0
MMD2_k127_2396342_14 PFAM peptidase zinc-dependent K06974 - - 0.00000000000000000000000000000000000000000000000000007382 197.0
MMD2_k127_2396342_15 Belongs to the UPF0146 family K09713 - - 0.0000000000000000000000000000000000000000000003656 177.0
MMD2_k127_2396342_16 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000000000000000000000000000000008084 169.0
MMD2_k127_2396342_17 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000007235 152.0
MMD2_k127_2396342_18 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000005866 122.0
MMD2_k127_2396342_19 transcription factor (CBF NF-Y) - - - 0.00000000000000000000000000006933 116.0
MMD2_k127_2396342_2 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 490.0
MMD2_k127_2396342_20 - - - - 0.00000000000000002681 88.0
MMD2_k127_2396342_3 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 479.0
MMD2_k127_2396342_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 389.0
MMD2_k127_2396342_5 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 348.0
MMD2_k127_2396342_6 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 335.0
MMD2_k127_2396342_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008813 321.0
MMD2_k127_2396342_8 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 299.0
MMD2_k127_2396342_9 methanogen marker protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001037 285.0
MMD2_k127_2407570_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1013.0
MMD2_k127_2407570_1 2Fe-2S iron-sulfur cluster binding domain - - - 9.757e-304 942.0
MMD2_k127_2407570_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007117 571.0
MMD2_k127_2407570_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 433.0
MMD2_k127_2407570_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 386.0
MMD2_k127_2407570_5 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 365.0
MMD2_k127_2407570_6 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005207 286.0
MMD2_k127_2407570_7 amino acid K16263 - - 0.0000000000000000000000000000000000000000000000000000000000000000001037 246.0
MMD2_k127_2407570_8 - - - - 0.000000000000000001222 101.0
MMD2_k127_2439039_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 2.007e-230 726.0
MMD2_k127_2439039_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 3.025e-202 635.0
MMD2_k127_2439039_10 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000002794 109.0
MMD2_k127_2439039_11 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000000008866 103.0
MMD2_k127_2439039_12 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000000001857 90.0
MMD2_k127_2439039_13 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000004102 78.0
MMD2_k127_2439039_2 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 440.0
MMD2_k127_2439039_3 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 380.0
MMD2_k127_2439039_4 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 356.0
MMD2_k127_2439039_5 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 307.0
MMD2_k127_2439039_6 Transcriptional regulator K07722 - - 0.00000000000000000000000000000000000000000000000000000000000000000004318 235.0
MMD2_k127_2439039_7 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000000004471 195.0
MMD2_k127_2439039_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000002189 140.0
MMD2_k127_2439039_9 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000000000000001141 133.0
MMD2_k127_2489765_0 acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 565.0
MMD2_k127_2489765_1 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 439.0
MMD2_k127_2493132_0 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 470.0
MMD2_k127_2493132_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 452.0
MMD2_k127_2493132_10 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000007558 116.0
MMD2_k127_2493132_11 structural constituent of ribosome K02924 - - 0.000000000000001341 83.0
MMD2_k127_2493132_12 CRS1_YhbY K07574 - - 0.00000000000007962 77.0
MMD2_k127_2493132_13 PFAM Ribosomal LX protein K02944 - - 0.00000000002257 68.0
MMD2_k127_2493132_2 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 316.0
MMD2_k127_2493132_3 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001735 271.0
MMD2_k127_2493132_4 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002009 267.0
MMD2_k127_2493132_5 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.00000000000000000000000000000000000000000000000000000001106 201.0
MMD2_k127_2493132_6 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000002569 143.0
MMD2_k127_2493132_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000002505 141.0
MMD2_k127_2493132_8 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000028 132.0
MMD2_k127_2493132_9 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.000000000000000000000000000000003378 136.0
MMD2_k127_2535012_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 391.0
MMD2_k127_2535012_1 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 323.0
MMD2_k127_2535012_2 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000015 106.0
MMD2_k127_2535313_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000147 267.0
MMD2_k127_2535313_1 Protein of unknown function, DUF488 - - - 0.000000000000000000000000008467 110.0
MMD2_k127_2535313_2 Protein of unknown function, DUF488 - - - 0.000000005419 57.0
MMD2_k127_2555781_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1552.0
MMD2_k127_2555781_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1057.0
MMD2_k127_2555781_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 609.0
MMD2_k127_2555781_3 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006328 457.0
MMD2_k127_2555781_4 transcription termination protein NusA K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000008235 221.0
MMD2_k127_2555781_5 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000000000000000000000000002791 126.0
MMD2_k127_2555781_6 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000009711 65.0
MMD2_k127_262941_0 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.0000000000000000000000000000000000000000000000001346 179.0
MMD2_k127_262941_1 - - - - 0.000000000000000002026 87.0
MMD2_k127_262941_3 Proline dehydrogenase - - - 0.0000000000371 69.0
MMD2_k127_2635463_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 486.0
MMD2_k127_2635463_1 Replication factor C K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 336.0
MMD2_k127_2635463_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002213 281.0
MMD2_k127_2635463_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004514 280.0
MMD2_k127_2635463_4 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000001207 241.0
MMD2_k127_2635463_5 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000002326 139.0
MMD2_k127_2642919_0 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000005274 207.0
MMD2_k127_2642919_1 - - - - 0.00000000263 61.0
MMD2_k127_2759101_0 toxin activity - - - 0.0000000000000000000000000000000000000000000000000001054 205.0
MMD2_k127_2759101_1 Domain of unknown function DUF11 - - - 0.000000000000000008741 94.0
MMD2_k127_2759101_2 - - - - 0.0000000000006567 81.0
MMD2_k127_278784_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 450.0
MMD2_k127_278784_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 361.0
MMD2_k127_278784_10 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.000000000000000000000000000000000001157 138.0
MMD2_k127_278784_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 351.0
MMD2_k127_278784_3 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 320.0
MMD2_k127_278784_4 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 295.0
MMD2_k127_278784_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000002353 268.0
MMD2_k127_278784_6 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000366 221.0
MMD2_k127_278784_7 hydrolase K04794 - 3.1.1.29 0.000000000000000000000000000000000000000000001064 168.0
MMD2_k127_278784_8 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000000000000106 160.0
MMD2_k127_278784_9 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000001149 156.0
MMD2_k127_2790166_0 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000008313 205.0
MMD2_k127_2790166_1 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000009224 201.0
MMD2_k127_2790166_2 Nitrite and sulphite reductase 4Fe-4S - - - 0.000001026 50.0
MMD2_k127_2818405_0 peptidyl-tyrosine sulfation - - - 2.206e-258 833.0
MMD2_k127_2818405_1 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 370.0
MMD2_k127_2818405_2 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 347.0
MMD2_k127_2818405_3 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009611 340.0
MMD2_k127_2818405_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000001738 211.0
MMD2_k127_2818405_5 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000000000000008382 118.0
MMD2_k127_2853144_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 485.0
MMD2_k127_2853144_1 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000003556 133.0
MMD2_k127_2854029_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.103e-215 683.0
MMD2_k127_2854029_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 1.199e-214 673.0
MMD2_k127_2854029_2 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 578.0
MMD2_k127_2854029_3 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000002325 206.0
MMD2_k127_2857722_0 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006818 284.0
MMD2_k127_2857722_1 PFAM Appr-1-p processing domain protein - - - 0.000000000000000000000000000000000000004454 151.0
MMD2_k127_2857722_2 Sodium hydrogen exchanger - - - 0.000000000000000000000000000339 128.0
MMD2_k127_2857722_3 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000002938 94.0
MMD2_k127_28771_0 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 492.0
MMD2_k127_28771_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 361.0
MMD2_k127_28771_2 Isoprenylcysteine carboxyl methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000007006 223.0
MMD2_k127_2919246_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 557.0
MMD2_k127_2919246_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 479.0
MMD2_k127_2919246_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003878 274.0
MMD2_k127_2919246_3 - - - - 0.0000000000000000000000000000000000000000000005301 171.0
MMD2_k127_2956779_0 PFAM type II secretion system protein E K07332 - - 2.689e-282 884.0
MMD2_k127_2956779_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 4.666e-226 712.0
MMD2_k127_2956779_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 2.36e-204 647.0
MMD2_k127_2956779_3 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009396 427.0
MMD2_k127_2956779_4 Type II secretion system (T2SS), protein F K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 402.0
MMD2_k127_2956779_5 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000000009538 189.0
MMD2_k127_2956779_6 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000001402 126.0
MMD2_k127_2956779_7 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.0000000000000000000000000001396 115.0
MMD2_k127_2956779_8 - - - - 0.0000000000000000000000008831 106.0
MMD2_k127_2985201_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009246 527.0
MMD2_k127_2985201_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 361.0
MMD2_k127_3004248_0 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 321.0
MMD2_k127_3004248_1 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000000000003603 177.0
MMD2_k127_3004248_2 Class III signal peptide - - - 0.00000000002738 67.0
MMD2_k127_3090200_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 5.347e-260 841.0
MMD2_k127_3090200_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 592.0
MMD2_k127_3090200_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000002028 141.0
MMD2_k127_3090200_3 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000001186 121.0
MMD2_k127_3090596_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 8.588e-233 724.0
MMD2_k127_3090596_1 Involved in cell shape control K22222 - - 4.915e-211 661.0
MMD2_k127_3090596_10 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000852 261.0
MMD2_k127_3090596_11 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000005567 228.0
MMD2_k127_3090596_12 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000001231 224.0
MMD2_k127_3090596_13 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000007054 219.0
MMD2_k127_3090596_14 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000000000000009538 223.0
MMD2_k127_3090596_15 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000001828 200.0
MMD2_k127_3090596_16 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.0000000000000000000000000000000000000000000000000000006469 194.0
MMD2_k127_3090596_17 PFAM Phosphatidylglycerophosphatase A - - - 0.00000000000000000000000000000000000000000000000000001714 191.0
MMD2_k127_3090596_18 Lysine exporter protein LysE YggA - - - 0.00000000000000000000000000000000000000000000000000006411 196.0
MMD2_k127_3090596_19 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000001878 174.0
MMD2_k127_3090596_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 4.145e-202 635.0
MMD2_k127_3090596_20 Belongs to the UPF0305 family - - - 0.00000000000000000000000000000000000000003757 158.0
MMD2_k127_3090596_21 - - - - 0.000000000000000000000000000000000009825 138.0
MMD2_k127_3090596_22 - - - - 0.00000000000000000000000000000000002615 143.0
MMD2_k127_3090596_23 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.000000000000000000000000000000002269 130.0
MMD2_k127_3090596_24 PFAM Glycosyl transferase family 2 K07027 - - 0.00000000000000000000000000000001078 139.0
MMD2_k127_3090596_25 Binds to the 23S rRNA K02896 - - 0.00000000000000000000000000001801 120.0
MMD2_k127_3090596_26 - - - - 0.00000000000000000000000000005716 130.0
MMD2_k127_3090596_3 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 621.0
MMD2_k127_3090596_4 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 578.0
MMD2_k127_3090596_5 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 499.0
MMD2_k127_3090596_6 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003981 423.0
MMD2_k127_3090596_7 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 415.0
MMD2_k127_3090596_8 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 333.0
MMD2_k127_3090596_9 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001326 271.0
MMD2_k127_3112252_0 Belongs to the peptidase S16 family - - - 0.0 1125.0
MMD2_k127_3112252_1 Belongs to the UPF0216 family K09737 - - 0.0000000000000000000000000000000000002167 145.0
MMD2_k127_3112252_2 HEPN domain - - - 0.00000000000003065 87.0
MMD2_k127_3112252_3 Putative zinc- or iron-chelating domain - - - 0.0000003194 55.0
MMD2_k127_3139230_0 Domain of unknown function DUF87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 494.0
MMD2_k127_3139230_1 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 381.0
MMD2_k127_3139230_2 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000003714 181.0
MMD2_k127_3179359_0 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 359.0
MMD2_k127_3179359_1 membrane-associated protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001864 263.0
MMD2_k127_3179359_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000001054 218.0
MMD2_k127_3179359_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000007323 183.0
MMD2_k127_3179359_4 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000002729 171.0
MMD2_k127_3179359_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000002883 158.0
MMD2_k127_3179359_6 - - - - 0.000000000002804 77.0
MMD2_k127_3192010_0 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 419.0
MMD2_k127_3192010_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007552 387.0
MMD2_k127_3192010_2 UV-endonuclease UvdE K13281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 362.0
MMD2_k127_3192010_3 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 306.0
MMD2_k127_3192010_4 PFAM HhH-GPD family protein K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 293.0
MMD2_k127_3192010_5 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007302 245.0
MMD2_k127_3192010_6 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000006095 229.0
MMD2_k127_3192010_7 NAD(P)H-binding K01784 - 5.1.3.2 0.000000248 53.0
MMD2_k127_3195745_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 1.854e-246 767.0
MMD2_k127_3195745_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 1.477e-210 663.0
MMD2_k127_3195745_10 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000000339 154.0
MMD2_k127_3195745_11 PFAM Thioredoxin K03671 - - 0.000000000000000000000000000000003359 130.0
MMD2_k127_3195745_12 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000000000004007 130.0
MMD2_k127_3195745_13 CAAX protease self-immunity - - - 0.000000000000000000000000007782 119.0
MMD2_k127_3195745_14 - - - - 0.00000000001621 74.0
MMD2_k127_3195745_15 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000001506 70.0
MMD2_k127_3195745_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 1.414e-199 625.0
MMD2_k127_3195745_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 421.0
MMD2_k127_3195745_4 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008263 261.0
MMD2_k127_3195745_5 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004218 251.0
MMD2_k127_3195745_6 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000004701 254.0
MMD2_k127_3195745_7 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000006091 193.0
MMD2_k127_3195745_8 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000000000000009371 174.0
MMD2_k127_3195745_9 B-block binding subunit of TFIIIC - - - 0.0000000000000000000000000000000000000000000003206 168.0
MMD2_k127_3201866_0 Belongs to the glutamate synthase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 579.0
MMD2_k127_3201866_1 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 284.0
MMD2_k127_3201866_2 Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - 0.00000000000000000000000000000000001749 144.0
MMD2_k127_3201866_3 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000005846 102.0
MMD2_k127_3201866_4 Protein of unknown function (DUF2769) - - - 0.0000000000000000002049 92.0
MMD2_k127_3201866_5 - - - - 0.0000000000000000007523 87.0
MMD2_k127_3201866_6 - - - - 0.0000003196 57.0
MMD2_k127_3222657_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 8.564e-230 721.0
MMD2_k127_3222657_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 559.0
MMD2_k127_3222657_10 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000000000000001644 207.0
MMD2_k127_3222657_11 Protein of unknown function (DUF3467) - - - 0.000000000000000000000000000000000000001368 149.0
MMD2_k127_3222657_12 DEAD DEAH box helicase domain protein K03725 - - 0.00000000000000000000000000000000000003555 146.0
MMD2_k127_3222657_13 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00001543 51.0
MMD2_k127_3222657_14 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00001818 50.0
MMD2_k127_3222657_15 - - - - 0.00002678 49.0
MMD2_k127_3222657_16 - - - - 0.00004134 56.0
MMD2_k127_3222657_2 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 396.0
MMD2_k127_3222657_3 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 384.0
MMD2_k127_3222657_4 PFAM amino acid-binding ACT domain protein K06862 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 314.0
MMD2_k127_3222657_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 299.0
MMD2_k127_3222657_6 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003199 279.0
MMD2_k127_3222657_7 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006971 261.0
MMD2_k127_3222657_8 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000001301 242.0
MMD2_k127_3222657_9 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000002246 223.0
MMD2_k127_3224272_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 606.0
MMD2_k127_3224272_1 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 455.0
MMD2_k127_3224272_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006968 275.0
MMD2_k127_3224272_3 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000001226 225.0
MMD2_k127_3224272_4 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000000000000000000001816 200.0
MMD2_k127_3224272_5 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000001027 143.0
MMD2_k127_3243395_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 2.36e-252 794.0
MMD2_k127_3243395_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 569.0
MMD2_k127_3243395_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 447.0
MMD2_k127_3243395_3 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 301.0
MMD2_k127_3243395_4 PFAM Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 297.0
MMD2_k127_3243395_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003146 269.0
MMD2_k127_3243395_6 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000002337 181.0
MMD2_k127_3244777_0 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 368.0
MMD2_k127_3244777_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000001091 245.0
MMD2_k127_3244777_2 GyrI-like small molecule binding domain - - - 0.000000000000000000000000000000000000000000009446 171.0
MMD2_k127_324594_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 519.0
MMD2_k127_324594_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 409.0
MMD2_k127_324594_2 DNA primase K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000003032 211.0
MMD2_k127_324594_3 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000004137 173.0
MMD2_k127_324594_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000002632 154.0
MMD2_k127_324594_5 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.0000000000001811 72.0
MMD2_k127_3259775_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.0 1278.0
MMD2_k127_3259775_1 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005978 578.0
MMD2_k127_3259775_10 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.0000000000000000000000000000000000000000000000002348 189.0
MMD2_k127_3259775_11 Hydrogenase maturation protease K08315 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.23.51 0.000000000000000000000000000000000000000000645 162.0
MMD2_k127_3259775_12 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K00338 - 1.6.5.3 0.000000000000000000000000000000000000003857 150.0
MMD2_k127_3259775_14 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K18017 - 1.12.7.2 0.0000000000000000000001621 104.0
MMD2_k127_3259775_15 4Fe-4S binding domain - - - 0.00000000003723 72.0
MMD2_k127_3259775_2 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit K00343,K05568,K14115,K22169 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 501.0
MMD2_k127_3259775_3 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 479.0
MMD2_k127_3259775_4 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K00333,K14090 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 421.0
MMD2_k127_3259775_5 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
MMD2_k127_3259775_6 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 307.0
MMD2_k127_3259775_7 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 285.0
MMD2_k127_3259775_8 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009581 287.0
MMD2_k127_3259775_9 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14088 - - 0.000000000000000000000000000000000000000000000000000000002496 203.0
MMD2_k127_3259802_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.0 1131.0
MMD2_k127_32600_1 - - - - 0.0000000000000000000002111 105.0
MMD2_k127_3278512_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 408.0
MMD2_k127_3337013_0 PFAM Beta propeller domain K14475 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 602.0
MMD2_k127_3337013_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000002392 135.0
MMD2_k127_3337013_2 - - - - 0.000000000000004719 79.0
MMD2_k127_3391391_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008204 506.0
MMD2_k127_3391391_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 359.0
MMD2_k127_3391391_10 Transcriptional regulator K07108 - - 0.00000000000000000000000000000007888 128.0
MMD2_k127_3391391_11 Glutaredoxin - - - 0.00000000000000000000000000005311 118.0
MMD2_k127_3391391_12 Glutaredoxin - - - 0.0000000000002179 78.0
MMD2_k127_3391391_2 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 317.0
MMD2_k127_3391391_3 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 305.0
MMD2_k127_3391391_4 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000000000002697 224.0
MMD2_k127_3391391_5 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000511 205.0
MMD2_k127_3391391_6 Molybdopterin converting factor K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000002315 192.0
MMD2_k127_3391391_7 TfuA-like protein - - - 0.0000000000000000000000000000000000001027 152.0
MMD2_k127_3391391_8 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000001482 147.0
MMD2_k127_3391391_9 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000000000000000000000000000134 140.0
MMD2_k127_3391587_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 510.0
MMD2_k127_3391587_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007667 443.0
MMD2_k127_3391587_2 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 429.0
MMD2_k127_3391587_3 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 355.0
MMD2_k127_3391587_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000003811 145.0
MMD2_k127_3391587_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000000000003053 135.0
MMD2_k127_3391587_6 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000003612 109.0
MMD2_k127_3395546_0 Fumarate reductase succinate dehydrogenase flavoprotein K00239 - 1.3.5.1,1.3.5.4 6.749e-243 763.0
MMD2_k127_3395546_1 Fumarase C C-terminus K01679,K01744 - 4.2.1.2,4.3.1.1 4.215e-194 619.0
MMD2_k127_3395546_2 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 577.0
MMD2_k127_3395546_3 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 514.0
MMD2_k127_3395546_4 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 454.0
MMD2_k127_3395546_5 COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 340.0
MMD2_k127_3395546_6 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 338.0
MMD2_k127_3395546_7 Chagasin family peptidase inhibitor I42 K14475 - - 0.00000000000000000000000000000000191 135.0
MMD2_k127_3395546_8 Rieske [2Fe-2S] domain - - - 0.00000000000000002915 85.0
MMD2_k127_3437964_0 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 620.0
MMD2_k127_3437964_1 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 511.0
MMD2_k127_3437964_2 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 370.0
MMD2_k127_3437964_3 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008016 291.0
MMD2_k127_3437964_4 Peptidase family M23 - - - 0.00000000000000000004326 93.0
MMD2_k127_3443725_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 9.28e-269 835.0
MMD2_k127_3443725_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.376e-260 824.0
MMD2_k127_3443725_10 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 535.0
MMD2_k127_3443725_11 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 518.0
MMD2_k127_3443725_12 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 465.0
MMD2_k127_3443725_13 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 456.0
MMD2_k127_3443725_14 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 439.0
MMD2_k127_3443725_15 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 441.0
MMD2_k127_3443725_16 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 428.0
MMD2_k127_3443725_17 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 438.0
MMD2_k127_3443725_18 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 385.0
MMD2_k127_3443725_19 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 379.0
MMD2_k127_3443725_2 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 6.497e-258 811.0
MMD2_k127_3443725_20 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007447 389.0
MMD2_k127_3443725_21 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 317.0
MMD2_k127_3443725_22 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 319.0
MMD2_k127_3443725_23 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 304.0
MMD2_k127_3443725_24 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 308.0
MMD2_k127_3443725_25 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 290.0
MMD2_k127_3443725_26 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000004588 255.0
MMD2_k127_3443725_27 O-methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001812 246.0
MMD2_k127_3443725_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003973 248.0
MMD2_k127_3443725_29 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001151 238.0
MMD2_k127_3443725_3 Protein of unknown function, DUF255 K06888 - - 4.612e-222 709.0
MMD2_k127_3443725_30 Domain of unknown function (DUF1724) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006332 239.0
MMD2_k127_3443725_31 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000000357 229.0
MMD2_k127_3443725_32 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000003946 214.0
MMD2_k127_3443725_33 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000001819 221.0
MMD2_k127_3443725_34 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000009911 212.0
MMD2_k127_3443725_35 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000000000000001912 195.0
MMD2_k127_3443725_36 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000318 192.0
MMD2_k127_3443725_37 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000000000000000000000000319 171.0
MMD2_k127_3443725_38 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.000000000000000000000000000000000000001094 155.0
MMD2_k127_3443725_39 - - - - 0.0000000000000000000000000000000000001099 145.0
MMD2_k127_3443725_4 amino acid K03294 - - 5.397e-207 653.0
MMD2_k127_3443725_40 - - - - 0.0000000000000000000000000000000000006268 149.0
MMD2_k127_3443725_41 - - - - 0.00000000000000000000000000000000607 136.0
MMD2_k127_3443725_42 helicase activity K06915 - - 0.0000000000000000000000000000003429 132.0
MMD2_k127_3443725_43 - - - - 0.000000000000000000000000002139 113.0
MMD2_k127_3443725_44 - - - - 0.000000000000000000000003024 106.0
MMD2_k127_3443725_45 - - - - 0.0000000000000009818 83.0
MMD2_k127_3443725_46 - - - - 0.0000000000001016 79.0
MMD2_k127_3443725_47 - K06868 - 2.5.1.73 0.000000000007118 67.0
MMD2_k127_3443725_48 TPR repeat-containing protein - - - 0.000000000007454 73.0
MMD2_k127_3443725_49 peptidase U32 K08303 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000088 67.0
MMD2_k127_3443725_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 1.861e-194 614.0
MMD2_k127_3443725_50 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000004458 62.0
MMD2_k127_3443725_51 - - - - 0.00000003695 62.0
MMD2_k127_3443725_52 SMART Tetratricopeptide domain protein - - - 0.000001304 58.0
MMD2_k127_3443725_6 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 574.0
MMD2_k127_3443725_7 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 564.0
MMD2_k127_3443725_8 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 572.0
MMD2_k127_3443725_9 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 554.0
MMD2_k127_3462814_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1143.0
MMD2_k127_3462814_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 451.0
MMD2_k127_3462814_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 439.0
MMD2_k127_3462814_3 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002896 276.0
MMD2_k127_3462814_4 AIR synthase related protein domain protein K04655 - - 0.0000000000000000000000000000000000000000000000002627 180.0
MMD2_k127_3462814_5 - - - - 0.0000000000000000000000000000002968 130.0
MMD2_k127_3462814_6 Ferredoxin K05337 - - 0.0000000000000000000001987 98.0
MMD2_k127_3462814_7 - - - - 0.000000000003871 69.0
MMD2_k127_3462814_8 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000667 66.0
MMD2_k127_3522707_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1420.0
MMD2_k127_3522707_1 tRNAHis guanylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001094 259.0
MMD2_k127_3529905_0 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007063 258.0
MMD2_k127_3529905_1 PFAM NAD dependent epimerase dehydratase family K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000005746 184.0
MMD2_k127_3529905_2 Polysaccharide biosynthesis protein K01711,K15856 - 1.1.1.281,4.2.1.47 0.000000000000000000000000000000000000000006012 166.0
MMD2_k127_3529905_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000003735 93.0
MMD2_k127_3553787_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 3.803e-315 977.0
MMD2_k127_3553787_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 602.0
MMD2_k127_3553787_10 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000166 232.0
MMD2_k127_3553787_11 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000001295 183.0
MMD2_k127_3553787_12 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000002501 180.0
MMD2_k127_3553787_13 SMART Excinuclease ABC, C subunit - - - 0.0000000000000000000000000000000000000000000356 165.0
MMD2_k127_3553787_14 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.000000000000000000000000000000000609 133.0
MMD2_k127_3553787_15 Multisubunit Na H antiporter MnhC subunit K00340,K05567,K14114 - 1.6.5.3 0.00000000000000000002275 99.0
MMD2_k127_3553787_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 601.0
MMD2_k127_3553787_3 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 546.0
MMD2_k127_3553787_4 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009567 531.0
MMD2_k127_3553787_5 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 518.0
MMD2_k127_3553787_6 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002025 249.0
MMD2_k127_3553787_7 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000002828 248.0
MMD2_k127_3553787_8 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001635 241.0
MMD2_k127_3553787_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000006464 230.0
MMD2_k127_3646623_0 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001653 231.0
MMD2_k127_3646623_1 - - - - 0.00000000000000000000000003903 115.0
MMD2_k127_3658525_0 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 577.0
MMD2_k127_3658525_1 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 435.0
MMD2_k127_3658525_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000008102 63.0
MMD2_k127_3798089_0 PFAM Thiolase K00626 - 2.3.1.9 6.802e-207 649.0
MMD2_k127_3798089_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 342.0
MMD2_k127_3798089_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000000000000000000005529 220.0
MMD2_k127_3888780_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 429.0
MMD2_k127_3888780_1 Domain of unknown function - - - 0.0000000000000000000000000000000000000003206 151.0
MMD2_k127_3965608_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 3.79e-201 646.0
MMD2_k127_3965608_1 PFAM TM2 domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000008441 240.0
MMD2_k127_3965608_2 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000005122 237.0
MMD2_k127_3965608_3 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.0000000000000000000000000000000000000000001304 173.0
MMD2_k127_3965608_4 DNA polymerase activity K02319 - 2.7.7.7 0.0000000000000000000000000000000000002635 150.0
MMD2_k127_3965608_5 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000005045 143.0
MMD2_k127_3965608_6 - K00960 - 2.7.7.6 0.0000000000000000000000000002444 116.0
MMD2_k127_3965608_7 Tetratricopeptide repeat - - - 0.00000000000000002693 91.0
MMD2_k127_3965608_8 Protein of unknown function (DUF2769) - - - 0.0000000000000048 78.0
MMD2_k127_3965608_9 - - - - 0.00000000004058 72.0
MMD2_k127_3976722_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 316.0
MMD2_k127_3976722_1 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000000000005687 238.0
MMD2_k127_3976722_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000002707 226.0
MMD2_k127_3976722_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000001626 226.0
MMD2_k127_3976722_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000009344 217.0
MMD2_k127_3976722_5 binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000001931 213.0
MMD2_k127_3976722_6 PFAM Ribosomal protein K02912 - - 0.000000000000000000000000000000001394 136.0
MMD2_k127_3976722_7 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000006773 123.0
MMD2_k127_3976722_8 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000000004654 99.0
MMD2_k127_3993335_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 558.0
MMD2_k127_3993335_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 544.0
MMD2_k127_3993335_2 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 481.0
MMD2_k127_3993335_3 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 373.0
MMD2_k127_3993335_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000404 223.0
MMD2_k127_3993335_5 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000000000000000000000000001428 191.0
MMD2_k127_3993335_6 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000003214 102.0
MMD2_k127_3994801_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.119e-270 844.0
MMD2_k127_3994801_1 Uncharacterized protein conserved in archaea (DUF2114) - - - 1.475e-255 795.0
MMD2_k127_3994801_10 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004615 271.0
MMD2_k127_3994801_11 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000002475 256.0
MMD2_k127_3994801_12 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000001107 196.0
MMD2_k127_3994801_13 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000002557 177.0
MMD2_k127_3994801_14 Uncharacterised protein family UPF0058 - - - 0.000000000000000000000000000000000000000005779 158.0
MMD2_k127_3994801_15 - - - - 0.00000000000000000000001392 102.0
MMD2_k127_3994801_16 Belongs to the UPF0235 family K09131 - - 0.00000000000005152 77.0
MMD2_k127_3994801_2 PFAM Radical SAM domain protein K06937 - - 2.785e-242 756.0
MMD2_k127_3994801_3 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 576.0
MMD2_k127_3994801_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 534.0
MMD2_k127_3994801_5 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 421.0
MMD2_k127_3994801_6 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 401.0
MMD2_k127_3994801_7 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 368.0
MMD2_k127_3994801_8 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 316.0
MMD2_k127_3994801_9 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 301.0
MMD2_k127_3995904_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 3.156e-289 902.0
MMD2_k127_3995904_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 9.192e-249 773.0
MMD2_k127_3995904_2 V-type ATPase 116kDa subunit family K02123 - - 8.937e-212 681.0
MMD2_k127_3995904_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 366.0
MMD2_k127_3995904_4 - - - - 0.0000000000000000000000000000000000000000000003137 171.0
MMD2_k127_3995904_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000103 138.0
MMD2_k127_3995904_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000002069 113.0
MMD2_k127_3995904_7 ATP synthase subunit C K02124 - - 0.0000000000000000002098 89.0
MMD2_k127_3995904_8 - - - - 0.0000000000000000008266 86.0
MMD2_k127_4006274_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 6.014e-199 627.0
MMD2_k127_4006274_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005049 571.0
MMD2_k127_4006274_10 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000009515 214.0
MMD2_k127_4006274_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000002017 216.0
MMD2_k127_4006274_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000203 204.0
MMD2_k127_4006274_13 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000005321 196.0
MMD2_k127_4006274_14 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000004424 168.0
MMD2_k127_4006274_15 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000001695 122.0
MMD2_k127_4006274_16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000003849 93.0
MMD2_k127_4006274_2 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 481.0
MMD2_k127_4006274_3 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 407.0
MMD2_k127_4006274_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 364.0
MMD2_k127_4006274_5 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 336.0
MMD2_k127_4006274_6 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 289.0
MMD2_k127_4006274_7 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007797 276.0
MMD2_k127_4006274_8 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001488 249.0
MMD2_k127_4006274_9 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009241 243.0
MMD2_k127_4009792_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.777e-209 662.0
MMD2_k127_4009792_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000832 374.0
MMD2_k127_4009792_2 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000000000000000000000000000000000000002178 237.0
MMD2_k127_4009792_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000004134 152.0
MMD2_k127_4030292_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 516.0
MMD2_k127_4030292_1 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 369.0
MMD2_k127_4030292_2 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006434 279.0
MMD2_k127_4030292_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001443 237.0
MMD2_k127_4030292_4 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000008171 179.0
MMD2_k127_4030292_5 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000007385 172.0
MMD2_k127_4030292_6 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000001151 136.0
MMD2_k127_4030292_7 Domain of unknown function (DUF1858) - - - 0.0000000000000000000002358 103.0
MMD2_k127_4030292_8 Phage integrase family K04763 - - 0.000008414 57.0
MMD2_k127_4079955_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 6.842e-269 852.0
MMD2_k127_4079955_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 532.0
MMD2_k127_4079955_10 Proline dehydrogenase K00318 - - 0.000000000000000001416 94.0
MMD2_k127_4079955_11 - - - - 0.0000000000001622 74.0
MMD2_k127_4079955_12 - K06193 - - 0.000000000007246 67.0
MMD2_k127_4079955_13 PFAM Protein kinase domain - - - 0.00004143 54.0
MMD2_k127_4079955_2 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 454.0
MMD2_k127_4079955_3 Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 389.0
MMD2_k127_4079955_4 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 299.0
MMD2_k127_4079955_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002048 276.0
MMD2_k127_4079955_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000156 236.0
MMD2_k127_4079955_7 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000000001212 208.0
MMD2_k127_4079955_8 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000001388 216.0
MMD2_k127_4079955_9 Belongs to the SfsA family K06206 - - 0.000000000000000000000000000000000000000000001424 180.0
MMD2_k127_4080568_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 522.0
MMD2_k127_4080568_1 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 329.0
MMD2_k127_4080568_2 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000008957 229.0
MMD2_k127_4094597_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 4.446e-220 690.0
MMD2_k127_4094597_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 325.0
MMD2_k127_4094597_10 Conserved repeat domain - - - 0.000000000003225 80.0
MMD2_k127_4094597_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000005209 61.0
MMD2_k127_4094597_2 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001166 284.0
MMD2_k127_4094597_3 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000000000000000000000000000002075 215.0
MMD2_k127_4094597_4 Kelch motif - - - 0.0000000000000000000000000000000000000000000000000000000775 221.0
MMD2_k127_4094597_5 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000004577 187.0
MMD2_k127_4094597_6 Kelch motif - - - 0.0000000000000000000000000000000000007216 161.0
MMD2_k127_4094597_7 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000011 145.0
MMD2_k127_4094597_8 - - - - 0.00000000000000000000000001355 113.0
MMD2_k127_4094597_9 Protein tyrosine kinase - - - 0.000000000000000006074 92.0
MMD2_k127_4169688_0 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 527.0
MMD2_k127_4169688_1 PFAM Peptidase M20 K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 390.0
MMD2_k127_4169688_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009116 371.0
MMD2_k127_4169688_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001381 278.0
MMD2_k127_4169688_4 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000000000000000009242 158.0
MMD2_k127_4169688_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000003835 89.0
MMD2_k127_4190576_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1703.0
MMD2_k127_4190576_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008762 582.0
MMD2_k127_4190576_10 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 360.0
MMD2_k127_4190576_11 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 332.0
MMD2_k127_4190576_12 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 342.0
MMD2_k127_4190576_13 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 312.0
MMD2_k127_4190576_14 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 302.0
MMD2_k127_4190576_15 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000276 275.0
MMD2_k127_4190576_16 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000003758 246.0
MMD2_k127_4190576_17 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000001305 235.0
MMD2_k127_4190576_18 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000004422 216.0
MMD2_k127_4190576_19 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000008575 218.0
MMD2_k127_4190576_2 TIGRFAM UbiD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 557.0
MMD2_k127_4190576_20 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000005478 216.0
MMD2_k127_4190576_21 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000001162 222.0
MMD2_k127_4190576_22 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000401 211.0
MMD2_k127_4190576_23 Protein of unknown function (DUF432) K09149 - - 0.00000000000000000000000000000000000000000000002342 179.0
MMD2_k127_4190576_24 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000000000000000002362 161.0
MMD2_k127_4190576_25 - - - - 0.0000000000000000000000000000000008294 137.0
MMD2_k127_4190576_26 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000007621 125.0
MMD2_k127_4190576_27 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000001555 121.0
MMD2_k127_4190576_28 HEAT repeat - - - 0.0000000000000000000003865 106.0
MMD2_k127_4190576_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 535.0
MMD2_k127_4190576_4 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 525.0
MMD2_k127_4190576_5 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 512.0
MMD2_k127_4190576_6 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 551.0
MMD2_k127_4190576_7 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 439.0
MMD2_k127_4190576_8 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 379.0
MMD2_k127_4190576_9 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 379.0
MMD2_k127_4228326_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 7.3e-303 940.0
MMD2_k127_4228326_1 Belongs to the TCP-1 chaperonin family K22447 - - 1.1e-227 716.0
MMD2_k127_4228326_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 602.0
MMD2_k127_4228326_3 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 361.0
MMD2_k127_4228326_4 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 306.0
MMD2_k127_4228326_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000006617 236.0
MMD2_k127_4228326_6 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000000004254 134.0
MMD2_k127_4271345_0 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 347.0
MMD2_k127_4271345_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003522 271.0
MMD2_k127_4271345_10 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000002446 67.0
MMD2_k127_4271345_11 PBS lyase HEAT-like repeat - - - 0.000000000003965 72.0
MMD2_k127_4271345_12 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.0000000002419 62.0
MMD2_k127_4271345_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003894 260.0
MMD2_k127_4271345_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001648 254.0
MMD2_k127_4271345_4 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000001419 202.0
MMD2_k127_4271345_5 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000518 156.0
MMD2_k127_4271345_6 PFAM SCP-like extracellular - - - 0.000000000000000000000000000000000001079 149.0
MMD2_k127_4271345_7 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000147 136.0
MMD2_k127_4271345_8 Zinc-ribbon containing domain - - - 0.0000000000000000000000003291 106.0
MMD2_k127_4271345_9 Peptidase M50 - - - 0.0000000000000000000000463 100.0
MMD2_k127_4320386_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000001058 235.0
MMD2_k127_4320386_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000003982 184.0
MMD2_k127_4320386_2 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.00000000000000000000000000005574 121.0
MMD2_k127_4320386_3 - - - - 0.0000000000000000000000000001121 120.0
MMD2_k127_4320386_4 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000004843 115.0
MMD2_k127_4320386_5 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000008249 88.0
MMD2_k127_4320386_6 Protein of unknown function (DUF2953) - - - 0.00000000000000002605 90.0
MMD2_k127_4321093_0 PFAM Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008685 473.0
MMD2_k127_4321093_1 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 293.0
MMD2_k127_4321093_2 - - - - 0.00000000000000000000000000000000000000000003467 169.0
MMD2_k127_4321093_3 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000003492 173.0
MMD2_k127_4321093_4 - - - - 0.000000000000000000000000000009084 122.0
MMD2_k127_4335691_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 7.201e-238 743.0
MMD2_k127_4337982_0 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 443.0
MMD2_k127_4337982_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 305.0
MMD2_k127_4337982_2 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009475 253.0
MMD2_k127_4337982_3 - - - - 0.0000000000000000000000000000000001075 140.0
MMD2_k127_4337982_4 PDGLE domain K02009 - - 0.00000001374 62.0
MMD2_k127_4347654_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.349e-227 717.0
MMD2_k127_4347654_1 beta-lactamase domain protein - - - 0.0000001288 54.0
MMD2_k127_4461532_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 484.0
MMD2_k127_4461532_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 488.0
MMD2_k127_4461532_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 481.0
MMD2_k127_4461532_3 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 317.0
MMD2_k127_4461532_4 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007823 303.0
MMD2_k127_4461532_5 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000003312 184.0
MMD2_k127_4461532_6 - K03686 - - 0.0000000000000000005409 94.0
MMD2_k127_4472301_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007395 545.0
MMD2_k127_4472301_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 526.0
MMD2_k127_4472301_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 344.0
MMD2_k127_4472301_3 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000001934 232.0
MMD2_k127_4472301_4 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000001087 155.0
MMD2_k127_4472301_5 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000001095 155.0
MMD2_k127_4554702_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1144.0
MMD2_k127_4554702_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007223 349.0
MMD2_k127_4554702_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 299.0
MMD2_k127_4558561_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit K01546 - 3.6.3.12 0.0 1092.0
MMD2_k127_4558561_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1067.0
MMD2_k127_4558561_2 Histidine kinase K07646 - 2.7.13.3 1.8e-216 691.0
MMD2_k127_4588987_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 547.0
MMD2_k127_4588987_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001047 273.0
MMD2_k127_4588987_2 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000000000000000000001208 225.0
MMD2_k127_4588987_3 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000001707 190.0
MMD2_k127_4588987_4 nucleic acid binding OB-fold tRNA helicase-type - - - 0.000000000000000000000006108 106.0
MMD2_k127_4588987_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000000001211 96.0
MMD2_k127_4588987_6 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000002084 93.0
MMD2_k127_4593405_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 1.891e-220 694.0
MMD2_k127_4593405_1 Helix-hairpin-helix domain K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 613.0
MMD2_k127_4593405_2 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 385.0
MMD2_k127_4593405_3 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 368.0
MMD2_k127_4593405_4 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001763 275.0
MMD2_k127_4600149_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.097e-279 872.0
MMD2_k127_4600149_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 8.211e-273 855.0
MMD2_k127_4600149_10 - - - - 0.000000000000000000000000004112 118.0
MMD2_k127_4600149_11 - - - - 0.000000000000000003317 86.0
MMD2_k127_4600149_13 COG0237 Dephospho-CoA kinase - - - 0.0000000000000004997 85.0
MMD2_k127_4600149_14 - - - - 0.0000000000000006094 83.0
MMD2_k127_4600149_15 - - - - 0.0000002631 55.0
MMD2_k127_4600149_16 - - - - 0.0003277 47.0
MMD2_k127_4600149_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.324e-225 704.0
MMD2_k127_4600149_3 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 456.0
MMD2_k127_4600149_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 337.0
MMD2_k127_4600149_5 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 309.0
MMD2_k127_4600149_6 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 295.0
MMD2_k127_4600149_7 Ras family K06945 - - 0.00000000000000000000000000000000000000000000000001209 187.0
MMD2_k127_4600149_8 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.0000000000000000000000000000000000001059 147.0
MMD2_k127_4600149_9 - - - - 0.000000000000000000000000000000000001886 141.0
MMD2_k127_4601981_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 587.0
MMD2_k127_4601981_1 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 340.0
MMD2_k127_4601981_2 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 321.0
MMD2_k127_4601981_3 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008358 293.0
MMD2_k127_4601981_4 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006619 277.0
MMD2_k127_4601981_5 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003412 247.0
MMD2_k127_4601981_6 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000004452 186.0
MMD2_k127_4601981_7 Glycosyl transferase family 41 - - - 0.0000002941 64.0
MMD2_k127_4601981_8 PBP superfamily domain K05772 - - 0.000003583 49.0
MMD2_k127_46074_0 Belongs to the MCM family K10726 - - 1.563e-233 730.0
MMD2_k127_4607424_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.509e-196 626.0
MMD2_k127_4607424_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 390.0
MMD2_k127_4607424_2 PFAM DNA methylase N-4 N-6 domain protein K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 376.0
MMD2_k127_4607424_3 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.000000000009138 73.0
MMD2_k127_4607424_4 - - - - 0.0000000904 54.0
MMD2_k127_4636249_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 578.0
MMD2_k127_4636249_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 413.0
MMD2_k127_4636249_2 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 296.0
MMD2_k127_4636249_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000001197 224.0
MMD2_k127_4636249_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000007052 184.0
MMD2_k127_4636249_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000000000000000001509 141.0
MMD2_k127_4636249_6 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000005133 107.0
MMD2_k127_4636249_7 - - - - 0.0000000000000000000000007518 105.0
MMD2_k127_4636249_8 Transcriptional regulator K07729 - - 0.0000000000000000000007888 96.0
MMD2_k127_4715062_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 469.0
MMD2_k127_4715062_1 Voltage gated chloride channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007415 434.0
MMD2_k127_4715062_2 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 291.0
MMD2_k127_4715062_3 PHP-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000009221 230.0
MMD2_k127_4715062_4 - - - - 0.000000000000000000000000000000000000000000002918 174.0
MMD2_k127_4715062_5 Sodium Bile acid symporter family K03453 - - 0.0000000000000000000000000000000004284 147.0
MMD2_k127_4715062_6 small multi-drug export - - - 0.00000000000000000002406 105.0
MMD2_k127_4715062_7 bile acid:sodium symporter activity K03453 - - 0.00000001788 62.0
MMD2_k127_4715062_8 META domain - - - 0.0001156 51.0
MMD2_k127_4728713_0 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 330.0
MMD2_k127_4728713_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000002212 225.0
MMD2_k127_4728713_2 PFAM TrkA-C domain K07228 - - 0.0000000000000000000000000000000000000000000000000000001479 200.0
MMD2_k127_4728713_3 PAS domain - - - 0.000000000000000000000002397 119.0
MMD2_k127_4728713_4 PFAM ABC-2 type transporter K09694 - - 0.000000002666 59.0
MMD2_k127_4755212_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1182.0
MMD2_k127_4755212_1 DEAD DEAH box helicase K06877 - - 6.559e-278 880.0
MMD2_k127_4755212_10 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 610.0
MMD2_k127_4755212_11 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 589.0
MMD2_k127_4755212_12 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008184 478.0
MMD2_k127_4755212_13 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 481.0
MMD2_k127_4755212_14 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 452.0
MMD2_k127_4755212_15 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 398.0
MMD2_k127_4755212_16 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 376.0
MMD2_k127_4755212_17 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 358.0
MMD2_k127_4755212_18 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 337.0
MMD2_k127_4755212_19 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 310.0
MMD2_k127_4755212_2 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.686e-252 789.0
MMD2_k127_4755212_20 Exonuclease K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 291.0
MMD2_k127_4755212_21 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007485 280.0
MMD2_k127_4755212_22 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001613 274.0
MMD2_k127_4755212_23 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000002709 265.0
MMD2_k127_4755212_24 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000001134 261.0
MMD2_k127_4755212_25 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001573 252.0
MMD2_k127_4755212_26 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000001061 255.0
MMD2_k127_4755212_27 PFAM PEGA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002046 259.0
MMD2_k127_4755212_28 Alpha/beta hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000001306 244.0
MMD2_k127_4755212_29 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000000000000005662 212.0
MMD2_k127_4755212_3 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 3.019e-237 744.0
MMD2_k127_4755212_30 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000000000000003437 208.0
MMD2_k127_4755212_31 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000008403 209.0
MMD2_k127_4755212_32 PFAM PUA domain containing protein K07575 - - 0.00000000000000000000000000000000000000000000000000000001179 203.0
MMD2_k127_4755212_33 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000003749 198.0
MMD2_k127_4755212_34 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000005085 196.0
MMD2_k127_4755212_35 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000007696 186.0
MMD2_k127_4755212_36 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000005958 181.0
MMD2_k127_4755212_37 NTPase - - - 0.000000000000000000000000000000000000000000003323 169.0
MMD2_k127_4755212_38 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000005723 161.0
MMD2_k127_4755212_39 - - - - 0.00000000000000000000000000000000000001352 151.0
MMD2_k127_4755212_4 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 5.605e-229 730.0
MMD2_k127_4755212_40 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000001942 144.0
MMD2_k127_4755212_41 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.0000000000000000000000000000008314 129.0
MMD2_k127_4755212_42 binds to the 23S rRNA K02922 - - 0.000000000000000000000002153 103.0
MMD2_k127_4755212_43 TIR domain - - - 0.000000001112 67.0
MMD2_k127_4755212_44 Phospholipid methyltransferase - - - 0.000000008022 64.0
MMD2_k127_4755212_45 TIR domain - - - 0.000000064 63.0
MMD2_k127_4755212_46 metallopeptidase activity - - - 0.0000003484 56.0
MMD2_k127_4755212_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 1.268e-224 711.0
MMD2_k127_4755212_6 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 9.444e-221 702.0
MMD2_k127_4755212_7 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 5.736e-213 668.0
MMD2_k127_4755212_8 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.346e-197 629.0
MMD2_k127_4755212_9 PFAM dihydropteroate synthase, DHPS - - - 3.62e-196 634.0
MMD2_k127_4766403_0 Protein of unknown function (DUF1102) - - - 0.00000000000000000000000000000000000000000000000000002058 210.0
MMD2_k127_4766403_1 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000000000000000002016 166.0
MMD2_k127_4766403_2 COG1202 Superfamily II helicase, archaea-specific - - - 0.0000000000000000000000000000000000006332 141.0
MMD2_k127_4766403_3 WD-40 repeat - - - 0.0000000000000002453 91.0
MMD2_k127_4766403_4 PFAM Prenyltransferase squalene oxidase - - - 0.000000003676 70.0
MMD2_k127_4776601_0 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002668 269.0
MMD2_k127_4776601_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008117 264.0
MMD2_k127_4776601_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000007533 250.0
MMD2_k127_4776601_3 AMP binding - - - 0.00000003609 62.0
MMD2_k127_4793814_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1027.0
MMD2_k127_4793814_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 8.954e-298 927.0
MMD2_k127_4828364_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 471.0
MMD2_k127_4828364_1 LUD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000401 253.0
MMD2_k127_4828364_2 bis(5'-adenosyl)-triphosphatase activity K02503,K19710 - 2.7.7.53 0.000000000000000000000000000000000000000005974 160.0
MMD2_k127_4864463_0 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 431.0
MMD2_k127_4864463_1 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 393.0
MMD2_k127_4864463_2 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000006982 269.0
MMD2_k127_4864463_3 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000004713 88.0
MMD2_k127_4864463_4 PRC-barrel domain - - - 0.000000000002088 70.0
MMD2_k127_4874258_0 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 309.0
MMD2_k127_4874258_1 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 323.0
MMD2_k127_4874258_2 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008608 271.0
MMD2_k127_4874258_3 Integral membrane protein DUF106 - - - 0.0000000000000000000000000000000000000000000000000000000000005803 216.0
MMD2_k127_4874258_4 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000002429 214.0
MMD2_k127_4874258_5 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000006599 90.0
MMD2_k127_4874258_6 - - - - 0.00000000000005846 76.0
MMD2_k127_4903380_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 428.0
MMD2_k127_4903380_1 serine-type endopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 389.0
MMD2_k127_4903380_2 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000003193 241.0
MMD2_k127_4903380_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000004294 232.0
MMD2_k127_4903380_4 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000179 68.0
MMD2_k127_4903380_6 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.000002295 54.0
MMD2_k127_4905647_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.148e-277 863.0
MMD2_k127_4905647_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009946 500.0
MMD2_k127_4905647_2 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 431.0
MMD2_k127_4905647_3 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007735 347.0
MMD2_k127_4905647_4 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000003245 197.0
MMD2_k127_4905647_5 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.000000000000000002918 85.0
MMD2_k127_4905647_6 PFAM Yip1 domain - - - 0.0000000004778 68.0
MMD2_k127_4915108_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 6.281e-205 651.0
MMD2_k127_4915108_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.409e-202 648.0
MMD2_k127_4915108_10 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000000000005454 222.0
MMD2_k127_4915108_11 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000883 160.0
MMD2_k127_4915108_12 PFAM thioesterase superfamily K02614 - - 0.00000000000000000000000000001253 123.0
MMD2_k127_4915108_13 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000001366 102.0
MMD2_k127_4915108_2 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 606.0
MMD2_k127_4915108_3 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 498.0
MMD2_k127_4915108_4 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 389.0
MMD2_k127_4915108_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 362.0
MMD2_k127_4915108_6 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 354.0
MMD2_k127_4915108_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 311.0
MMD2_k127_4915108_8 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000004494 236.0
MMD2_k127_4915108_9 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000002623 232.0
MMD2_k127_4957610_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K02474 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 569.0
MMD2_k127_4957610_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 401.0
MMD2_k127_4957610_2 transferase hexapeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002585 254.0
MMD2_k127_4957610_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000001685 239.0
MMD2_k127_4961719_0 STAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 617.0
MMD2_k127_4961719_1 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 528.0
MMD2_k127_4961719_2 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009858 503.0
MMD2_k127_4961719_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 432.0
MMD2_k127_4961719_4 Peptidyl-prolyl cis-trans isomerase K01802,K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000002729 234.0
MMD2_k127_4961719_6 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000001618 112.0
MMD2_k127_4961719_7 Cupin domain - - - 0.00000000000000000000003633 99.0
MMD2_k127_4963411_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 492.0
MMD2_k127_4963411_1 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 330.0
MMD2_k127_4963411_2 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000001249 140.0
MMD2_k127_4963411_3 protein conserved in archaea K09746 - - 0.000000000000000000000000001274 122.0
MMD2_k127_4980041_0 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 551.0
MMD2_k127_4980041_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 519.0
MMD2_k127_4980041_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 497.0
MMD2_k127_4980041_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 427.0
MMD2_k127_4980041_4 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 315.0
MMD2_k127_4980041_5 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001049 262.0
MMD2_k127_4980041_6 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000009394 200.0
MMD2_k127_4980041_7 Peptidase M50 - - - 0.000000000000000000000000000000000000000001325 159.0
MMD2_k127_4980041_8 chorismate mutase K04093 - 5.4.99.5 0.0000000000000000000000001402 110.0
MMD2_k127_5004068_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 455.0
MMD2_k127_5004068_1 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000001448 231.0
MMD2_k127_5004068_2 - - - - 0.00000000000000000000000000002834 119.0
MMD2_k127_5011934_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.675e-214 675.0
MMD2_k127_5011934_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 320.0
MMD2_k127_5011934_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 283.0
MMD2_k127_5011934_3 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000001983 155.0
MMD2_k127_5011934_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000004316 123.0
MMD2_k127_5051286_0 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 535.0
MMD2_k127_5051286_1 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000009531 266.0
MMD2_k127_5060156_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 2.748e-216 677.0
MMD2_k127_5060156_1 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 430.0
MMD2_k127_5060156_2 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.000000000000000000000000000000000000000000000000000000000000000000007751 240.0
MMD2_k127_5060156_3 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.00000000000000000000000000000000000000000000000000000155 196.0
MMD2_k127_5060156_4 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000000000000000000000006561 199.0
MMD2_k127_5066678_0 KH, type 1, domain K07041 - - 0.0 1078.0
MMD2_k127_5066678_1 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 421.0
MMD2_k127_5066678_10 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000003463 108.0
MMD2_k127_5066678_11 but it may be involved in stabilization of the trimeric complex - - - 0.000000000000006727 75.0
MMD2_k127_5066678_12 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000002684 73.0
MMD2_k127_5066678_2 Mitochondrial small ribosomal subunit Rsm22 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 415.0
MMD2_k127_5066678_3 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 381.0
MMD2_k127_5066678_4 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009053 332.0
MMD2_k127_5066678_5 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 333.0
MMD2_k127_5066678_6 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 294.0
MMD2_k127_5066678_7 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000008091 194.0
MMD2_k127_5066678_8 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.00000000000000000000000000000000000000000000005425 173.0
MMD2_k127_5066678_9 - - - - 0.000000000000000000000000000002244 122.0
MMD2_k127_5066889_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 461.0
MMD2_k127_5066889_1 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 372.0
MMD2_k127_5066889_2 Histidine kinase - - - 0.00000000000000000000319 107.0
MMD2_k127_5066889_3 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.00000000004536 63.0
MMD2_k127_5066889_4 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0001225 52.0
MMD2_k127_5068001_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 417.0
MMD2_k127_5068001_1 glycosyl transferase, family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 391.0
MMD2_k127_5068001_2 - - - - 0.000000000000000000000000000000000000000000000000000000007969 203.0
MMD2_k127_5068001_3 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000003351 58.0
MMD2_k127_5091167_0 Belongs to the glutamate synthase family - - - 4.436e-271 848.0
MMD2_k127_5091167_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 1.292e-247 773.0
MMD2_k127_5091167_2 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 588.0
MMD2_k127_5091167_3 PFAM glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 565.0
MMD2_k127_5091167_4 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 406.0
MMD2_k127_5091167_5 PFAM glutamate synthase alpha subunit domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 335.0
MMD2_k127_5104806_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 325.0
MMD2_k127_5106138_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 4.558e-287 902.0
MMD2_k127_5106138_1 Involved in regulation of DNA replication K10725 - - 1.827e-202 645.0
MMD2_k127_5106138_10 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00001206 47.0
MMD2_k127_5106138_2 PFAM Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 569.0
MMD2_k127_5106138_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 496.0
MMD2_k127_5106138_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 445.0
MMD2_k127_5106138_5 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 351.0
MMD2_k127_5106138_6 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000000000006507 238.0
MMD2_k127_5106138_7 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000008171 211.0
MMD2_k127_5106138_8 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000004931 205.0
MMD2_k127_5106138_9 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000003413 180.0
MMD2_k127_5158418_0 Sodium hydrogen exchanger K03455 - - 1.215e-202 643.0
MMD2_k127_5161_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 439.0
MMD2_k127_5161_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 350.0
MMD2_k127_5161_2 Belongs to the N(4) N(6)-methyltransferase family K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007978 298.0
MMD2_k127_5161_3 PFAM Abortive infection protein - - - 0.000000000000000000001651 104.0
MMD2_k127_5188901_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 468.0
MMD2_k127_5188901_1 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 426.0
MMD2_k127_5188901_10 - - - - 0.00000000000005357 79.0
MMD2_k127_5188901_11 - - - - 0.00000000009101 70.0
MMD2_k127_5188901_2 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 394.0
MMD2_k127_5188901_3 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000227 197.0
MMD2_k127_5188901_4 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000000000000000000000000000000000000002129 184.0
MMD2_k127_5188901_5 toxin activity - - - 0.00000000000000000000000000000000000000000003527 173.0
MMD2_k127_5188901_6 - - - - 0.000000000000000000000000000000000000000001387 174.0
MMD2_k127_5188901_7 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000009304 171.0
MMD2_k127_5188901_8 - - - - 0.000000000000000000000000000000000000002412 151.0
MMD2_k127_5188901_9 - - - - 0.00000000000000000000000003786 115.0
MMD2_k127_5195823_0 Ferrous iron transport B domain protein K04759 - - 2.109e-204 659.0
MMD2_k127_5195823_1 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 381.0
MMD2_k127_5195823_2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 295.0
MMD2_k127_5195823_3 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000005868 209.0
MMD2_k127_5195823_4 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000006989 164.0
MMD2_k127_5195823_5 iron dependent repressor K03709,K04758 - - 0.000000000000000000000000000000000000005001 153.0
MMD2_k127_5195823_6 Protein of unknown function (DUF357) K09728 - - 0.00000000000000000000000000000007512 134.0
MMD2_k127_5195823_7 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000001017 112.0
MMD2_k127_5204936_0 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 341.0
MMD2_k127_5204936_1 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 310.0
MMD2_k127_5204936_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000001635 246.0
MMD2_k127_5204936_3 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000007593 237.0
MMD2_k127_5231365_0 SMART Elongator protein 3 MiaB NifB - - - 2.788e-236 742.0
MMD2_k127_5231365_1 phosphoesterase RecJ domain protein - - - 8.461e-213 671.0
MMD2_k127_5231365_2 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 440.0
MMD2_k127_5231365_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000001459 233.0
MMD2_k127_5231365_4 PFAM PRC-barrel domain - - - 0.0000000000000000000000003603 123.0
MMD2_k127_5273131_0 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001186 271.0
MMD2_k127_5273131_1 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000005238 195.0
MMD2_k127_5288638_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 7.705e-291 899.0
MMD2_k127_5288638_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 1.658e-244 762.0
MMD2_k127_5288638_2 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 3.724e-218 686.0
MMD2_k127_5288638_3 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007715 565.0
MMD2_k127_5288638_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 317.0
MMD2_k127_5288638_5 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000003093 253.0
MMD2_k127_5288638_6 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000000000000000000000000000000000000006078 220.0
MMD2_k127_5288638_7 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000194 212.0
MMD2_k127_5288638_8 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000000000000000246 204.0
MMD2_k127_5360617_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 599.0
MMD2_k127_5360617_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 550.0
MMD2_k127_5360617_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 463.0
MMD2_k127_5360617_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 346.0
MMD2_k127_5360617_4 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 311.0
MMD2_k127_5360617_5 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000003365 233.0
MMD2_k127_5360617_6 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.000000000000000000000000000000000001716 147.0
MMD2_k127_5360617_7 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.0000000000000000000001746 109.0
MMD2_k127_5360617_8 COG0589 Universal stress protein UspA and related nucleotide-binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000001229 81.0
MMD2_k127_5360617_9 Domain of unknown function - - - 0.00000001568 66.0
MMD2_k127_5375379_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 1.888e-217 685.0
MMD2_k127_5375379_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 424.0
MMD2_k127_5375379_10 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000006227 74.0
MMD2_k127_5375379_2 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 359.0
MMD2_k127_5375379_3 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 306.0
MMD2_k127_5375379_4 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000001864 222.0
MMD2_k127_5375379_5 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000009461 175.0
MMD2_k127_5375379_6 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000001533 159.0
MMD2_k127_5375379_7 metal-binding protein - - - 0.000000000000000000000000000202 119.0
MMD2_k127_5375379_8 PFAM Ribosomal protein S27E K02978 - - 0.00000000000000000000000101 106.0
MMD2_k127_5375379_9 PFAM ADP-ribosylation Crystallin J1 - - - 0.000000000000000000002336 97.0
MMD2_k127_5389522_0 P-type ATPase K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 369.0
MMD2_k127_5389522_1 Small multi-drug export protein - - - 0.000000000000000000000000000000000000000004939 160.0
MMD2_k127_5389522_2 Secreted repeat of unknown function - - - 0.00000000000000000000000000000006757 131.0
MMD2_k127_5389522_3 PFAM Yip1 domain - - - 0.00000000157 69.0
MMD2_k127_539549_0 integral membrane protein - - - 0.0000000000000000000000000000000000002459 148.0
MMD2_k127_539549_1 Major Facilitator Superfamily - - - 0.00000000001972 66.0
MMD2_k127_5468733_0 TIGRFAM methyltransferase FkbM family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006272 251.0
MMD2_k127_5468733_1 Protein of unknown function (DUF4013) - - - 0.000000000000000000000000000000000000000000000000000000000000005436 227.0
MMD2_k127_5468733_2 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000003831 190.0
MMD2_k127_5468733_3 PFAM Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000000007467 182.0
MMD2_k127_5468733_4 Peptidase family M54 K06974 - - 0.000000000000000000000000000000000002567 145.0
MMD2_k127_5489154_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008365 553.0
MMD2_k127_5489154_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 484.0
MMD2_k127_5489154_10 - - - - 0.0000000000000000000009083 101.0
MMD2_k127_5489154_11 Trm112p-like protein - - - 0.000000000000000001242 88.0
MMD2_k127_5489154_2 SMART zinc finger, CDGSH-type domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 388.0
MMD2_k127_5489154_3 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008927 375.0
MMD2_k127_5489154_4 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000002161 261.0
MMD2_k127_5489154_5 sugar phosphatases of the HAD superfamily K02566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005954 256.0
MMD2_k127_5489154_6 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001324 235.0
MMD2_k127_5489154_7 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000001414 229.0
MMD2_k127_5489154_8 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000006749 197.0
MMD2_k127_5489154_9 TIGRFAM molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000000000000000001199 127.0
MMD2_k127_5493827_0 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 359.0
MMD2_k127_5493827_1 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 331.0
MMD2_k127_5493827_2 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 306.0
MMD2_k127_5493827_3 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000008284 131.0
MMD2_k127_5493827_4 Protein of unknown function (DUF1622) - - - 0.0000000000000000000002983 102.0
MMD2_k127_5500980_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 5.833e-231 729.0
MMD2_k127_5500980_1 Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008208 271.0
MMD2_k127_5501354_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1141.0
MMD2_k127_5501354_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.109e-211 666.0
MMD2_k127_5501354_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.796e-198 630.0
MMD2_k127_5501354_3 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000007056 212.0
MMD2_k127_5501354_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000000000000000000000000000000000000001877 158.0
MMD2_k127_5501354_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000001213 102.0
MMD2_k127_5501354_6 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000001682 57.0
MMD2_k127_550443_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 493.0
MMD2_k127_550443_1 Belongs to the RtcB family K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 410.0
MMD2_k127_550443_2 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 389.0
MMD2_k127_550443_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002301 250.0
MMD2_k127_550443_4 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.000000000000000000000000000000000000000000000000000000000000000001983 235.0
MMD2_k127_550443_5 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000000000000000000000000000000000001975 202.0
MMD2_k127_550443_6 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000002521 212.0
MMD2_k127_550443_7 PFAM BioY protein K03523 - - 0.000000000000000000000000000000000000000000000000004973 185.0
MMD2_k127_5562238_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 339.0
MMD2_k127_5562238_1 Fumarase C-terminus K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001312 276.0
MMD2_k127_5562238_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.0000000000000000000000000000000000000000004808 158.0
MMD2_k127_5562238_3 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000002525 49.0
MMD2_k127_5564469_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1206.0
MMD2_k127_5564469_1 PFAM ABC transporter K00400 - - 1.963e-271 843.0
MMD2_k127_5564469_10 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008132 284.0
MMD2_k127_5564469_11 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000002524 177.0
MMD2_k127_5564469_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 5.06e-203 641.0
MMD2_k127_5564469_3 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 600.0
MMD2_k127_5564469_4 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 418.0
MMD2_k127_5564469_5 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 413.0
MMD2_k127_5564469_6 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 392.0
MMD2_k127_5564469_7 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 374.0
MMD2_k127_5564469_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 358.0
MMD2_k127_5564469_9 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 323.0
MMD2_k127_5590138_0 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 401.0
MMD2_k127_5590138_1 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 356.0
MMD2_k127_5590138_2 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000009062 256.0
MMD2_k127_5590138_3 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000004059 137.0
MMD2_k127_5590138_4 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000003896 117.0
MMD2_k127_5590138_5 Belongs to the MCM family K10726 - - 0.000000001038 60.0
MMD2_k127_5590326_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 7.686e-237 747.0
MMD2_k127_5590326_1 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000002095 171.0
MMD2_k127_5607292_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 414.0
MMD2_k127_5607292_1 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 335.0
MMD2_k127_5607292_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009743 295.0
MMD2_k127_5607292_3 PFAM PEGA domain - - - 0.000000000000000000000000000000000000000000000000000000000003881 222.0
MMD2_k127_5607292_4 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000001802 218.0
MMD2_k127_5607292_5 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000001286 94.0
MMD2_k127_5612642_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.519e-258 804.0
MMD2_k127_5612642_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 571.0
MMD2_k127_5612642_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 506.0
MMD2_k127_5612642_3 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000001264 271.0
MMD2_k127_5612642_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000003886 256.0
MMD2_k127_5612642_5 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000009376 227.0
MMD2_k127_5612642_6 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000000000000000000006314 219.0
MMD2_k127_5612642_7 COG1202 Superfamily II helicase, archaea-specific - - - 0.00000000000000000000000000000000000000000003719 165.0
MMD2_k127_5612642_8 PFAM thioesterase superfamily - - - 0.0000000000000000000000000001024 117.0
MMD2_k127_5612642_9 - - - - 0.00000000000000000000007858 111.0
MMD2_k127_562426_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1178.0
MMD2_k127_562426_1 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 3.397e-210 660.0
MMD2_k127_562426_10 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.00000000000000000000000000000000000000000000008271 174.0
MMD2_k127_562426_11 - - - - 0.00000000000000000000000000000000000000006388 159.0
MMD2_k127_562426_2 PFAM formate nitrite transporter K21993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 493.0
MMD2_k127_562426_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 402.0
MMD2_k127_562426_4 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 385.0
MMD2_k127_562426_5 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 360.0
MMD2_k127_562426_6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000002638 262.0
MMD2_k127_562426_7 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009573 252.0
MMD2_k127_562426_8 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000005734 221.0
MMD2_k127_562426_9 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000000000003336 187.0
MMD2_k127_5653418_0 DEAD DEAH box helicase domain protein K03724 - - 4.526e-214 673.0
MMD2_k127_5653418_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 301.0
MMD2_k127_5656189_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 3.275e-219 691.0
MMD2_k127_5656189_1 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 536.0
MMD2_k127_5656189_2 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 524.0
MMD2_k127_5656189_3 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 445.0
MMD2_k127_5656189_4 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 354.0
MMD2_k127_5656189_5 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 284.0
MMD2_k127_5656189_6 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002045 273.0
MMD2_k127_5656189_7 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009952 269.0
MMD2_k127_5656189_8 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000403 261.0
MMD2_k127_5656189_9 Protein of unknown function (DUF1614) - - - 0.000000000000000000000000000000000000000000000000000000000000001036 226.0
MMD2_k127_5712309_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 2.625e-268 837.0
MMD2_k127_5712309_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 481.0
MMD2_k127_5712309_2 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 317.0
MMD2_k127_5712309_3 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001443 270.0
MMD2_k127_5712309_4 - - - - 0.0000000000000000004368 90.0
MMD2_k127_5712309_5 Transglutaminase-like superfamily - - - 0.0002938 48.0
MMD2_k127_5712321_0 Sodium Bile acid symporter family K03453 - - 0.0000000000000000000000001232 117.0
MMD2_k127_5712321_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000005207 62.0
MMD2_k127_5716121_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.541e-213 671.0
MMD2_k127_5716121_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 586.0
MMD2_k127_5716121_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000001519 239.0
MMD2_k127_5716121_11 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000009772 220.0
MMD2_k127_5716121_12 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.000000000000000000000000000000000000000000000002429 178.0
MMD2_k127_5716121_13 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000007896 119.0
MMD2_k127_5716121_14 Nucleotidyltransferase domain K07076 - - 0.0000000000000000000345 94.0
MMD2_k127_5716121_15 PFAM Uncharacterised conserved protein UCP006577 - - - 0.000000000000001006 81.0
MMD2_k127_5716121_16 Protein of unknown function DUF86 - - - 0.00000000001801 70.0
MMD2_k127_5716121_2 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 565.0
MMD2_k127_5716121_3 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 558.0
MMD2_k127_5716121_4 PFAM Flavodoxin nitric oxide synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 511.0
MMD2_k127_5716121_5 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 471.0
MMD2_k127_5716121_6 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 404.0
MMD2_k127_5716121_7 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 392.0
MMD2_k127_5716121_8 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 384.0
MMD2_k127_5716121_9 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 383.0
MMD2_k127_5759787_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 514.0
MMD2_k127_5759787_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 399.0
MMD2_k127_5759787_2 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 336.0
MMD2_k127_5759787_3 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000000000005227 222.0
MMD2_k127_5759787_4 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000000000000000000000000142 178.0
MMD2_k127_5759787_5 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000001794 66.0
MMD2_k127_5766324_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 381.0
MMD2_k127_5766324_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 358.0
MMD2_k127_5766324_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000006986 203.0
MMD2_k127_5766324_3 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000001065 127.0
MMD2_k127_5766324_4 - - - - 0.00002705 49.0
MMD2_k127_5791766_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1720.0
MMD2_k127_5791766_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 599.0
MMD2_k127_5791766_2 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 583.0
MMD2_k127_5791766_3 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 520.0
MMD2_k127_5791766_4 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007997 284.0
MMD2_k127_5791766_5 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000517 231.0
MMD2_k127_5791766_6 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000001225 178.0
MMD2_k127_5791766_7 Protein of unknown function (DUF4231) - - - 0.000000000000000000000000000000000000000000004172 168.0
MMD2_k127_5791766_8 beta-lactamase domain protein - - - 0.0000000000000116 76.0
MMD2_k127_5801951_0 - - - - 0.0000000000000000000000000001121 128.0
MMD2_k127_5801971_0 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 338.0
MMD2_k127_5801971_1 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000361 178.0
MMD2_k127_5801971_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000001321 70.0
MMD2_k127_5860931_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 2.014e-246 765.0
MMD2_k127_5860931_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.655e-237 746.0
MMD2_k127_5860931_10 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000003084 223.0
MMD2_k127_5860931_11 - - - - 0.00000000000000000000000000000000000000000000000000009949 196.0
MMD2_k127_5860931_12 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000001083 186.0
MMD2_k127_5860931_13 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000001018 119.0
MMD2_k127_5860931_14 - - - - 0.00000000000000000003905 95.0
MMD2_k127_5860931_16 - - - - 0.000000000001169 72.0
MMD2_k127_5860931_17 UbiA prenyltransferase family K02548 - 2.5.1.74 0.00001353 57.0
MMD2_k127_5860931_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 449.0
MMD2_k127_5860931_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 433.0
MMD2_k127_5860931_4 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 397.0
MMD2_k127_5860931_5 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 387.0
MMD2_k127_5860931_6 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 310.0
MMD2_k127_5860931_7 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001532 267.0
MMD2_k127_5860931_8 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002885 262.0
MMD2_k127_5860931_9 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000001804 255.0
MMD2_k127_5898640_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 464.0
MMD2_k127_5898640_1 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 437.0
MMD2_k127_5898640_2 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 356.0
MMD2_k127_5898640_3 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000003574 142.0
MMD2_k127_5898640_5 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000001386 74.0
MMD2_k127_5937248_0 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 454.0
MMD2_k127_596059_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 1.135e-273 844.0
MMD2_k127_596059_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 576.0
MMD2_k127_596059_10 PFAM Thiolase K00626 - 2.3.1.9 0.0002922 49.0
MMD2_k127_596059_2 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006899 539.0
MMD2_k127_596059_3 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 527.0
MMD2_k127_596059_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 525.0
MMD2_k127_596059_5 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 484.0
MMD2_k127_596059_6 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 321.0
MMD2_k127_596059_7 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 287.0
MMD2_k127_596059_8 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006121 250.0
MMD2_k127_596059_9 Coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.00000000000000000000000000000000000000004007 158.0
MMD2_k127_5965826_0 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 514.0
MMD2_k127_5965826_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 444.0
MMD2_k127_5965826_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 421.0
MMD2_k127_5965826_3 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 383.0
MMD2_k127_5965826_4 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 314.0
MMD2_k127_5965826_5 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 314.0
MMD2_k127_5965826_6 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000001916 243.0
MMD2_k127_5965826_7 PFAM response regulator receiver K03406 - - 0.000000000000000000000000000000000000000261 155.0
MMD2_k127_5966717_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 9.243e-233 729.0
MMD2_k127_5970199_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 582.0
MMD2_k127_5970199_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 454.0
MMD2_k127_5970199_2 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 447.0
MMD2_k127_5970199_3 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008619 243.0
MMD2_k127_5970199_4 - - - - 0.0000000000000000005476 87.0
MMD2_k127_5970199_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.000000000000000001165 86.0
MMD2_k127_5970199_6 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000001283 79.0
MMD2_k127_598985_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 434.0
MMD2_k127_598985_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000000000000003996 194.0
MMD2_k127_598985_2 - - - - 0.0000000004525 63.0
MMD2_k127_598985_3 - - - - 0.00003477 54.0
MMD2_k127_6017304_0 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000005117 194.0
MMD2_k127_6017304_1 - - - - 0.000000000000000002705 91.0
MMD2_k127_6017304_2 Belongs to the 'phage' integrase family K04763,K19591 - - 0.000004518 54.0
MMD2_k127_6027234_0 SMART Elongator protein 3 MiaB NifB - - - 4.072e-250 786.0
MMD2_k127_6027234_1 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000000000000000000000000000000000000000002628 211.0
MMD2_k127_6027234_2 - - - - 0.00000000000000000000000001131 118.0
MMD2_k127_6027234_3 Macro domain protein - - - 0.000000000000000000008461 99.0
MMD2_k127_6067513_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 454.0
MMD2_k127_6067513_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 440.0
MMD2_k127_6067513_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 436.0
MMD2_k127_6067513_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 394.0
MMD2_k127_6067513_4 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 373.0
MMD2_k127_6067513_5 protein conserved in archaea - - - 0.00000000000000000000000000005071 118.0
MMD2_k127_6067513_6 - - - - 0.00000000677 62.0
MMD2_k127_6131692_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 2.215e-237 738.0
MMD2_k127_6131692_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 546.0
MMD2_k127_6131692_2 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000006715 233.0
MMD2_k127_6131692_3 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000000000000000000000000000009949 197.0
MMD2_k127_6131692_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000001037 185.0
MMD2_k127_6131692_5 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.0000000000000000000000000000000000000003432 154.0
MMD2_k127_6131692_6 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.0000000000000000000001867 102.0
MMD2_k127_6131692_7 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000000000000008921 96.0
MMD2_k127_6258049_0 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000005405 147.0
MMD2_k127_6258049_1 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000004175 133.0
MMD2_k127_6258049_2 PFAM metallophosphoesterase K07096 - - 0.000000005574 58.0
MMD2_k127_6262872_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 366.0
MMD2_k127_6262872_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 328.0
MMD2_k127_6262872_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000001011 56.0
MMD2_k127_632318_0 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 475.0
MMD2_k127_632318_1 - - - - 0.00000000000000000000002493 109.0
MMD2_k127_648943_0 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000002311 158.0
MMD2_k127_648943_1 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.00000000000000000000000000007311 119.0
MMD2_k127_648943_2 Multisubunit Na H antiporter MnhC subunit K00340,K05567 - 1.6.5.3 0.000000000000002413 80.0
MMD2_k127_648943_3 Domain of unknown function (DUF4040) - - - 0.0001057 49.0
MMD2_k127_6741_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 6.948e-274 852.0
MMD2_k127_6741_1 COG1668 ABC-type Na efflux pump, permease component - - - 1.5e-204 653.0
MMD2_k127_6741_10 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002288 272.0
MMD2_k127_6741_11 Pas domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005781 253.0
MMD2_k127_6741_12 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000000002266 197.0
MMD2_k127_6741_13 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000000009817 187.0
MMD2_k127_6741_14 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000000000000004928 176.0
MMD2_k127_6741_15 PFAM ribosomal protein S8E K02995 - - 0.00000000000000000000000000000000000000000000005349 173.0
MMD2_k127_6741_16 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.0000000000000000000000000000000000000000004439 162.0
MMD2_k127_6741_17 - - - - 0.0000000000000000000000000000000000001539 149.0
MMD2_k127_6741_18 Histidine kinase - - - 0.000000000000000000000000000000003074 147.0
MMD2_k127_6741_19 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000007437 124.0
MMD2_k127_6741_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 582.0
MMD2_k127_6741_20 - K00960 - 2.7.7.6 0.00000000000000000000000000007789 115.0
MMD2_k127_6741_21 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000000005669 117.0
MMD2_k127_6741_22 RNA-binding protein involved in rRNA processing K07569 - - 0.0000000000000000005342 88.0
MMD2_k127_6741_23 - - - - 0.0002148 51.0
MMD2_k127_6741_3 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 484.0
MMD2_k127_6741_4 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 422.0
MMD2_k127_6741_5 PFAM response regulator receiver K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 439.0
MMD2_k127_6741_6 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 386.0
MMD2_k127_6741_7 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 370.0
MMD2_k127_6741_8 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 350.0
MMD2_k127_6741_9 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 318.0
MMD2_k127_694527_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1148.0
MMD2_k127_694527_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.78e-203 639.0
MMD2_k127_694527_10 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000007668 131.0
MMD2_k127_694527_11 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000001221 97.0
MMD2_k127_694527_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000003945 99.0
MMD2_k127_694527_13 - - - - 0.00000000000000359 81.0
MMD2_k127_694527_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 486.0
MMD2_k127_694527_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 355.0
MMD2_k127_694527_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 351.0
MMD2_k127_694527_5 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 331.0
MMD2_k127_694527_6 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 320.0
MMD2_k127_694527_7 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 311.0
MMD2_k127_694527_8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 302.0
MMD2_k127_694527_9 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000009288 232.0
MMD2_k127_712201_0 PFAM type II secretion system protein E K07332 - - 1.566e-224 709.0
MMD2_k127_712201_1 type II secretion system protein K07333 - - 6.674e-201 647.0
MMD2_k127_712201_2 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 311.0
MMD2_k127_712201_3 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 297.0
MMD2_k127_712201_4 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002273 267.0
MMD2_k127_741528_0 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007957 249.0
MMD2_k127_741528_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000001173 181.0
MMD2_k127_741528_2 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000006786 169.0
MMD2_k127_741528_3 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000001054 156.0
MMD2_k127_768996_0 Cytidylyltransferase K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 295.0
MMD2_k127_768996_1 HpcH/HpaI aldolase/citrate lyase family K00979,K02510 - 2.7.7.38,4.1.2.52 0.00000000000000000000000000003823 120.0
MMD2_k127_776886_0 archaeal Zn-finger protein - - - 0.000000000000000000000000000000000000000000000000000000005159 205.0
MMD2_k127_776886_1 Domain of unknown function (DUF371) K09738 - - 0.000000000000000000000000000000000000000000000738 175.0
MMD2_k127_776886_2 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.000000000000000000000000000000000000000919 153.0
MMD2_k127_776886_3 SnoaL-like domain - - - 0.000000000000000000000000002618 116.0
MMD2_k127_776886_4 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000001561 95.0
MMD2_k127_776886_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000002223 60.0
MMD2_k127_795738_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1026.0
MMD2_k127_795738_1 DEAD DEAH box helicase domain protein K03725 - - 2.121e-234 737.0
MMD2_k127_795738_10 Antibiotic biosynthesis monooxygenase - - - 0.00000000000001214 79.0
MMD2_k127_795738_11 - - - - 0.00000000000001519 80.0
MMD2_k127_795738_2 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 544.0
MMD2_k127_795738_3 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 396.0
MMD2_k127_795738_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 380.0
MMD2_k127_795738_5 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 308.0
MMD2_k127_795738_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000002571 239.0
MMD2_k127_795738_7 formamidopyrimidine-DNA glycosylase K05522 - 4.2.99.18 0.0000000000000000000000000000000000000000000005938 177.0
MMD2_k127_795738_8 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000002872 146.0
MMD2_k127_795738_9 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000006658 121.0
MMD2_k127_798182_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001941 280.0
MMD2_k127_798182_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000327 88.0
MMD2_k127_798182_3 H subunit K02107 - - 0.0000000001102 65.0
MMD2_k127_812682_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1129.0
MMD2_k127_812682_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 2.197e-247 773.0
MMD2_k127_812682_10 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 389.0
MMD2_k127_812682_11 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 366.0
MMD2_k127_812682_12 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 321.0
MMD2_k127_812682_13 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004193 268.0
MMD2_k127_812682_14 methyltransferase small K07579 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007301 242.0
MMD2_k127_812682_15 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000004509 212.0
MMD2_k127_812682_16 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000003223 203.0
MMD2_k127_812682_17 - - - - 0.00000000000000000000000000000000000000000000008412 188.0
MMD2_k127_812682_18 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000000001257 163.0
MMD2_k127_812682_19 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000002851 155.0
MMD2_k127_812682_2 LOR SDH bifunctional enzyme conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 601.0
MMD2_k127_812682_20 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000000000008357 127.0
MMD2_k127_812682_21 - - - - 0.000000000000000000000000000214 120.0
MMD2_k127_812682_22 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000000000000000000002984 93.0
MMD2_k127_812682_23 - - - - 0.0000000000000003663 81.0
MMD2_k127_812682_24 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000004408 51.0
MMD2_k127_812682_25 - - - - 0.00000158 58.0
MMD2_k127_812682_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 591.0
MMD2_k127_812682_4 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 587.0
MMD2_k127_812682_5 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 525.0
MMD2_k127_812682_6 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009827 507.0
MMD2_k127_812682_7 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008288 433.0
MMD2_k127_812682_8 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 425.0
MMD2_k127_812682_9 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 417.0
MMD2_k127_815816_0 PFAM ferredoxin-dependent glutamate synthase - - - 9.569e-281 869.0
MMD2_k127_815816_1 tetratricopeptide repeat - - - 1.514e-205 725.0
MMD2_k127_815816_10 - - - - 0.0000000000000000000000000000000000000000000000000000001259 211.0
MMD2_k127_815816_11 TIR domain - - - 0.000000000000000000000000000000000000000000000000000001449 224.0
MMD2_k127_815816_12 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000001984 196.0
MMD2_k127_815816_13 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000000008916 165.0
MMD2_k127_815816_14 transporter K07238,K11021 - - 0.000000000000000000000000000000007516 136.0
MMD2_k127_815816_15 Tetratricopeptide repeat K09667 GO:0000003,GO:0000123,GO:0000785,GO:0000791,GO:0001678,GO:0001932,GO:0001933,GO:0001934,GO:0002119,GO:0002164,GO:0002237,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005543,GO:0005547,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0006040,GO:0006041,GO:0006047,GO:0006048,GO:0006073,GO:0006091,GO:0006109,GO:0006110,GO:0006111,GO:0006112,GO:0006139,GO:0006140,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006473,GO:0006475,GO:0006479,GO:0006486,GO:0006493,GO:0006508,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007444,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008150,GO:0008152,GO:0008194,GO:0008213,GO:0008219,GO:0008289,GO:0008361,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009791,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010638,GO:0010646,GO:0010675,GO:0010799,GO:0010801,GO:0010876,GO:0010906,GO:0010941,GO:0012501,GO:0012505,GO:0015980,GO:0016020,GO:0016043,GO:0016262,GO:0016311,GO:0016407,GO:0016410,GO:0016485,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016579,GO:0016740,GO:0016746,GO:0016747,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0018022,GO:0018023,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019904,GO:0019915,GO:0022607,GO:0023051,GO:0023052,GO:0030141,GO:0030162,GO:0030246,GO:0030808,GO:0030811,GO:0030900,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031410,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033135,GO:0033137,GO:0033157,GO:0033218,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034645,GO:0034654,GO:0034968,GO:0035020,GO:0035091,GO:0035220,GO:0035295,GO:0035556,GO:0036094,GO:0036211,GO:0036477,GO:0040024,GO:0042176,GO:0042177,GO:0042221,GO:0042277,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042588,GO:0042592,GO:0042593,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043255,GO:0043412,GO:0043413,GO:0043414,GO:0043434,GO:0043467,GO:0043470,GO:0043543,GO:0043933,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045475,GO:0045793,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0046349,GO:0046483,GO:0046578,GO:0046626,GO:0048015,GO:0048017,GO:0048029,GO:0048311,GO:0048312,GO:0048471,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051056,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051223,GO:0051224,GO:0051235,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051276,GO:0051291,GO:0051568,GO:0051604,GO:0051640,GO:0051641,GO:0051646,GO:0051704,GO:0051707,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060255,GO:0060322,GO:0060341,GO:0060429,GO:0060548,GO:0061085,GO:0061087,GO:0061136,GO:0062012,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070085,GO:0070201,GO:0070206,GO:0070207,GO:0070208,GO:0070646,GO:0070647,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071375,GO:0071396,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0080182,GO:0090066,GO:0090087,GO:0090313,GO:0090315,GO:0090317,GO:0097237,GO:0097363,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:0140096,GO:1900037,GO:1900038,GO:1900076,GO:1900180,GO:1900182,GO:1900371,GO:1900542,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901799,GO:1901981,GO:1902275,GO:1902493,GO:1902494,GO:1902531,GO:1902680,GO:1903050,GO:1903051,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903533,GO:1903578,GO:1903827,GO:1903828,GO:1903829,GO:1904950,GO:1905269,GO:1905475,GO:1905476,GO:1990234,GO:2000058,GO:2000059,GO:2000112,GO:2000377,GO:2000379,GO:2001141,GO:2001169,GO:2001252 2.4.1.255 0.000000000000000000000000003295 134.0
MMD2_k127_815816_16 Tetratricopeptide repeat - - - 0.000000000194 78.0
MMD2_k127_815816_17 TIR domain - - - 0.0000000002787 67.0
MMD2_k127_815816_18 peroxisome matrix targeting signal-1 binding K13342 GO:0000268,GO:0002119,GO:0002164,GO:0002791,GO:0002793,GO:0003674,GO:0005048,GO:0005052,GO:0005215,GO:0005216,GO:0005217,GO:0005221,GO:0005261,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006605,GO:0006625,GO:0006810,GO:0006811,GO:0006812,GO:0006886,GO:0006887,GO:0006996,GO:0007031,GO:0007275,GO:0008104,GO:0008150,GO:0008324,GO:0009791,GO:0009966,GO:0009987,GO:0010646,GO:0010647,GO:0010817,GO:0015031,GO:0015075,GO:0015267,GO:0015276,GO:0015318,GO:0015833,GO:0015919,GO:0016020,GO:0016043,GO:0016192,GO:0016558,GO:0016560,GO:0017016,GO:0017038,GO:0017137,GO:0019899,GO:0022803,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022857,GO:0022890,GO:0023051,GO:0023056,GO:0030425,GO:0031090,GO:0031267,GO:0031903,GO:0032501,GO:0032502,GO:0032879,GO:0032940,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034220,GO:0034613,GO:0036477,GO:0042221,GO:0042277,GO:0042391,GO:0042493,GO:0042579,GO:0042886,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043235,GO:0043574,GO:0043855,GO:0043949,GO:0044057,GO:0044060,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044743,GO:0045055,GO:0045184,GO:0045185,GO:0046883,GO:0046887,GO:0046903,GO:0046907,GO:0048471,GO:0048518,GO:0048522,GO:0048583,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051286,GO:0051459,GO:0051461,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0065007,GO:0065008,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072347,GO:0072594,GO:0072662,GO:0072663,GO:0090087,GO:0090276,GO:0090277,GO:0097447,GO:0097458,GO:0098588,GO:0098655,GO:0098805,GO:0099094,GO:0120025,GO:0120038,GO:1902531,GO:1903530,GO:1903532 - 0.000000005189 73.0
MMD2_k127_815816_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 4.356e-195 624.0
MMD2_k127_815816_3 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 489.0
MMD2_k127_815816_4 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 409.0
MMD2_k127_815816_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 388.0
MMD2_k127_815816_6 protein N-acetylglucosaminyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006134 355.0
MMD2_k127_815816_7 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009692 312.0
MMD2_k127_815816_8 TIGRFAM MIP family channel K02440,K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008636 266.0
MMD2_k127_815816_9 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000004592 267.0
MMD2_k127_869957_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007383 521.0
MMD2_k127_869957_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 444.0
MMD2_k127_869957_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 406.0
MMD2_k127_869957_3 Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 397.0
MMD2_k127_869957_4 Cobalt transport protein K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001232 280.0
MMD2_k127_869957_5 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000001714 157.0
MMD2_k127_869957_6 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000005832 68.0
MMD2_k127_869957_7 COG1403 Restriction endonuclease K07451 - - 0.00000001873 64.0
MMD2_k127_885371_0 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006998 375.0
MMD2_k127_885371_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 332.0
MMD2_k127_885371_2 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000006264 192.0
MMD2_k127_885371_3 - - - - 0.000000000000000002558 93.0
MMD2_k127_885371_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.0000007738 57.0
MMD2_k127_894256_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1478.0
MMD2_k127_894256_1 Protein of unknown function (DUF460) K09150 - - 1.855e-218 709.0
MMD2_k127_894256_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002354 283.0
MMD2_k127_894256_11 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001881 269.0
MMD2_k127_894256_12 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000769 267.0
MMD2_k127_894256_13 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000007473 213.0
MMD2_k127_894256_14 PFAM transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000000000006199 211.0
MMD2_k127_894256_15 PFAM PP-loop domain protein - - - 0.0000000000000000000000000000000000000000000001202 178.0
MMD2_k127_894256_2 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 528.0
MMD2_k127_894256_3 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 490.0
MMD2_k127_894256_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 445.0
MMD2_k127_894256_5 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009793 455.0
MMD2_k127_894256_6 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 419.0
MMD2_k127_894256_7 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 379.0
MMD2_k127_894256_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 349.0
MMD2_k127_894256_9 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 315.0
MMD2_k127_901591_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007628 462.0
MMD2_k127_901591_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 364.0
MMD2_k127_901591_10 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000001149 112.0
MMD2_k127_901591_11 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.0000000000000000000000002071 113.0
MMD2_k127_901591_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000001487 99.0
MMD2_k127_901591_2 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 347.0
MMD2_k127_901591_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 338.0
MMD2_k127_901591_4 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000005584 226.0
MMD2_k127_901591_5 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000000006818 218.0
MMD2_k127_901591_6 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000000000000003887 207.0
MMD2_k127_901591_7 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000000001761 207.0
MMD2_k127_901591_8 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000000000000000454 176.0
MMD2_k127_901591_9 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000006267 166.0
MMD2_k127_945483_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 2.835e-243 762.0
MMD2_k127_945483_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 4.278e-196 618.0
MMD2_k127_945483_2 PFAM peptidase U32 K08303 - - 1.859e-195 651.0
MMD2_k127_945483_3 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000782 361.0
MMD2_k127_945483_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003215 285.0
MMD2_k127_945483_5 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000008362 199.0
MMD2_k127_945483_6 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000009022 183.0
MMD2_k127_945483_7 - - - - 0.0000000000000000000000000000009727 130.0
MMD2_k127_945483_8 - - - - 0.000000000000000000000000000001383 132.0
MMD2_k127_947690_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 379.0
MMD2_k127_947690_1 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000001706 227.0
MMD2_k127_947690_2 Cytochrome C biogenesis protein - - - 0.0000000000000000000000000000000193 143.0
MMD2_k127_947690_3 Cytochrome C biogenesis protein - - - 0.0001924 54.0
MMD2_k127_967316_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 287.0
MMD2_k127_967316_1 Flavodoxin - - - 0.000000000000000000000000000000000000000001965 161.0
MMD2_k127_967316_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000006926 77.0
MMD2_k127_96894_0 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 567.0
MMD2_k127_96894_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 547.0
MMD2_k127_96894_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000003414 89.0
MMD2_k127_96894_11 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000006317 88.0
MMD2_k127_96894_12 AAA domain K07321 - - 0.00000001197 58.0
MMD2_k127_96894_13 tetratricopeptide repeat - - - 0.00000006002 63.0
MMD2_k127_96894_2 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 374.0
MMD2_k127_96894_3 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 340.0
MMD2_k127_96894_4 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002353 276.0
MMD2_k127_96894_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000001016 243.0
MMD2_k127_96894_6 Protein phosphatase 2C - - - 0.000000000000000000000000000000000000000000000000000000000000000000008231 247.0
MMD2_k127_96894_7 COG0515 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001616 237.0
MMD2_k127_96894_8 PAS domain K02030 - - 0.0000000000000000000000000000000000000000000000000001457 207.0
MMD2_k127_96894_9 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000002878 94.0
MMD2_k127_995951_0 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 574.0
MMD2_k127_995951_1 haloacid dehalogenase-like hydrolase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007127 347.0
MMD2_k127_995951_2 Short C-terminal domain K08982 - - 0.00000000000000000000003903 102.0
MMD2_k127_995951_3 Mechanosensitive ion channel K16052 - - 0.00000000000000002475 83.0
MMD2_k127_995951_4 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000005108 79.0
MMD2_k127_995951_5 - - - - 0.0000002164 56.0