Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
1.62e-264
815.0
MMGS2_k127_1035952_3
Mn2 and Fe2 transporters of the NRAMP family
-
-
-
6.351e-254
787.0
MMGS2_k127_1035952_4
PFAM Na dependent nucleoside transporter
K03317
-
-
3.211e-243
756.0
MMGS2_k127_1035952_5
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
7.972e-229
710.0
MMGS2_k127_1035952_6
Thioredoxin-like domain
-
-
-
3.091e-227
704.0
MMGS2_k127_1035952_7
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1634.0
MMGS2_k127_1345203_1
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
0.0
1259.0
MMGS2_k127_1345203_10
Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.00000000000000000000000000000000000000000007723
161.0
MMGS2_k127_1345203_33
-
K06950
-
-
0.000000000000000000000000000000000000001368
149.0
MMGS2_k127_1345203_34
S23 ribosomal protein
-
-
-
0.00000000000000000000000000000002257
129.0
MMGS2_k127_1345203_4
Cysteine-rich domain
-
-
-
8.735e-304
939.0
MMGS2_k127_1345203_5
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
1.073e-219
684.0
MMGS2_k127_1427444_2
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
3577.0
MMGS2_k127_1701757_1
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.0
1537.0
MMGS2_k127_1701757_10
OsmC-like protein
K06889,K07397
-
-
1.321e-245
762.0
MMGS2_k127_1701757_11
protein conserved in bacteria
-
-
-
3.335e-219
681.0
MMGS2_k127_1701757_12
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1308.0
MMGS2_k127_1701757_30
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
0.0
1489.0
MMGS2_k127_1721290_1
DNA segregation ATPase FtsK SpoIIIE
K03466
-
-
0.0
1475.0
MMGS2_k127_1721290_10
AAA ATPase, central domain protein
K07478
-
-
1.952e-283
873.0
MMGS2_k127_1721290_11
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
3.404e-278
859.0
MMGS2_k127_1721290_12
Peptidogalycan biosysnthesis/recognition
K09919
-
-
9.526e-264
813.0
MMGS2_k127_1721290_13
A domain family that is part of the cupin metalloenzyme superfamily.
K18850
-
1.14.11.47
1.243e-254
788.0
MMGS2_k127_1721290_14
COG0477 Permeases of the major facilitator superfamily
-
-
-
1.091e-249
774.0
MMGS2_k127_1721290_15
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
K06176
-
5.4.99.27
2.023e-217
676.0
MMGS2_k127_1721290_16
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
K00384
-
1.8.1.9
5.966e-202
631.0
MMGS2_k127_1721290_17
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Belongs to the Glu Leu Phe Val dehydrogenases family
K00261
-
1.4.1.3
4.3e-310
952.0
MMGS2_k127_1721290_7
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
2.555e-306
939.0
MMGS2_k127_1721290_8
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
6.913e-290
895.0
MMGS2_k127_1721290_9
Protein conserved in bacteria
-
-
-
2.603e-286
894.0
MMGS2_k127_1816091_0
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
9.354e-268
825.0
MMGS2_k127_1816091_1
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K03732
-
3.6.4.13
6.334e-266
821.0
MMGS2_k127_1816091_2
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
4Fe-4S ferredoxin iron-sulfur binding domain protein
K11473
-
-
1.041e-264
825.0
MMGS2_k127_1884975_11
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
1.637e-264
815.0
MMGS2_k127_1884975_12
Major Facilitator Superfamily
-
-
-
2.657e-261
809.0
MMGS2_k127_1884975_13
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K19804
-
-
2.672e-258
797.0
MMGS2_k127_1884975_14
Beta-lactamase
-
-
-
4.614e-255
789.0
MMGS2_k127_1884975_15
TLC ATP/ADP transporter
-
-
-
5.396e-251
778.0
MMGS2_k127_1884975_16
D-isomer specific 2-hydroxyacid dehydrogenase
K00058
-
1.1.1.399,1.1.1.95
7.035e-246
763.0
MMGS2_k127_1884975_17
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
1.994e-234
727.0
MMGS2_k127_1884975_24
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.977e-230
715.0
MMGS2_k127_1884975_25
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K00831
-
2.6.1.52
8.253e-230
715.0
MMGS2_k127_1884975_26
Reduces the stability of FtsZ polymers in the presence of ATP
K06916
-
-
5.981e-227
705.0
MMGS2_k127_1884975_27
PFAM FAD linked oxidase domain protein
K11472
-
-
1.546e-223
694.0
MMGS2_k127_1884975_28
PFAM Prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
1.108e-221
689.0
MMGS2_k127_1884975_29
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K11752
-
1.1.1.193,3.5.4.26
1.982e-213
665.0
MMGS2_k127_1884975_3
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1472.0
MMGS2_k127_1884975_30
PFAM AIR synthase related protein domain protein
-
-
-
1.019e-208
652.0
MMGS2_k127_1884975_31
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K02017
-
3.6.3.29
3.339e-203
638.0
MMGS2_k127_1884975_32
PFAM peptidase
K04774
-
-
4.871e-201
630.0
MMGS2_k127_1884975_33
PFAM 2Fe-2S iron-sulfur cluster binding domain
K00523
-
1.17.1.1
8.924e-201
627.0
MMGS2_k127_1884975_34
TRAP transporter solute receptor TAXI family
K07080
-
-
9.895e-199
624.0
MMGS2_k127_1884975_35
Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
COG1629 Outer membrane receptor proteins, mostly Fe transport
K02014
-
-
0.0
1496.0
MMGS2_k127_1920528_10
FIST N domain
-
-
-
1.123e-244
756.0
MMGS2_k127_1920528_11
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
6.147e-236
734.0
MMGS2_k127_1920528_12
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
-
-
-
2.878e-231
721.0
MMGS2_k127_1920528_13
4 iron, 4 sulfur cluster binding
K00226,K02574
-
1.3.98.1
1.05e-229
716.0
MMGS2_k127_1920528_14
PFAM aldo keto reductase
-
-
-
2.608e-222
690.0
MMGS2_k127_1920528_15
PFAM peptidase
-
-
-
1.006e-220
689.0
MMGS2_k127_1920528_16
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TamB, inner membrane protein subunit of TAM complex
K09800
-
-
0.0
2425.0
MMGS2_k127_195677_1
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
1.131e-277
854.0
MMGS2_k127_2043940_11
Protein of unknown function (DUF3300)
-
-
-
2.197e-275
856.0
MMGS2_k127_2043940_12
cell redox homeostasis
-
-
-
3.972e-269
830.0
MMGS2_k127_2043940_13
PFAM Aminotransferase class I and II
K14267
-
2.6.1.17
2.119e-264
814.0
MMGS2_k127_2043940_14
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
3.956e-263
813.0
MMGS2_k127_2043940_15
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
2.599e-262
810.0
MMGS2_k127_2043940_16
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
1.062e-252
782.0
MMGS2_k127_2043940_17
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
8.281e-251
774.0
MMGS2_k127_2043940_18
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
1.072e-244
756.0
MMGS2_k127_2043940_19
Belongs to the DegT DnrJ EryC1 family
-
-
-
2.303e-226
707.0
MMGS2_k127_2043940_2
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1815.0
MMGS2_k127_2043940_20
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
2.769e-224
698.0
MMGS2_k127_2043940_21
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K02536
-
2.3.1.191
2.121e-207
647.0
MMGS2_k127_2043940_22
-
-
-
-
4.639e-206
642.0
MMGS2_k127_2043940_23
S-adenosylmethionine-dependent methyltransferase
K06969
-
2.1.1.191
6.02e-204
636.0
MMGS2_k127_2043940_24
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0
1173.0
MMGS2_k127_2188831_2
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
3.608e-270
844.0
MMGS2_k127_2285580_0
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0
1290.0
MMGS2_k127_229119_1
COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit
K15060
-
-
5.204e-222
693.0
MMGS2_k127_229119_10
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
TamB, inner membrane protein subunit of TAM complex
K09800
-
-
0.00000000000000000000000000000000000000002654
152.0
MMGS2_k127_2405746_0
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
2.946e-234
726.0
MMGS2_k127_2405746_1
Belongs to the FPP GGPP synthase family
K02523
-
2.5.1.90
3.371e-194
623.0
MMGS2_k127_2405746_2
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
acetyltransferases and hydrolases with the alpha beta hydrolase fold
-
-
-
0.0
1060.0
MMGS2_k127_249425_130
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.0000000000000000000000000000000000000000001677
160.0
MMGS2_k127_249425_131
PFAM Cold-shock protein, DNA-binding
K03704
-
-
0.00000000000000000000000000000000000007509
141.0
MMGS2_k127_249425_132
Flavin and coenzyme A sequestration protein dodecin
K09165
-
-
0.000000000000000000000000000000000003045
139.0
MMGS2_k127_249425_133
-
-
-
-
0.0000000000000000000000000000000004624
134.0
MMGS2_k127_249425_134
Protein of unknown function (DUF3175)
-
-
-
0.000000000000000000000000000000004074
128.0
MMGS2_k127_249425_135
COG1397 ADP-ribosylglycohydrolase
K05521
-
3.2.2.24
0.000000000000000000000000000003412
124.0
MMGS2_k127_249425_136
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.000000000000000000000000003896
117.0
MMGS2_k127_249425_137
-
-
-
-
0.0000000000000000000004916
96.0
MMGS2_k127_249425_138
Methyltransferase
-
-
-
0.000000000000000000001167
96.0
MMGS2_k127_249425_14
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K15633
-
5.4.2.12
0.0
1020.0
MMGS2_k127_249425_140
Domain of unknown function DUF302
-
-
-
0.000000000001072
76.0
MMGS2_k127_249425_141
Domain in cystathionine beta-synthase and other proteins.
-
-
-
0.0000000001381
62.0
MMGS2_k127_249425_142
TIGRFAM ATP-dependent helicase HrpA
K03578
-
3.6.4.13
0.00000009584
54.0
MMGS2_k127_249425_143
Rhomboid family
-
-
-
0.0000003712
59.0
MMGS2_k127_249425_144
COG1680 Beta-lactamase class C and other penicillin binding proteins
-
-
-
0.0000009853
51.0
MMGS2_k127_249425_145
TIGRFAM ATP-dependent helicase HrpA
K03578
-
3.6.4.13
0.00008226
45.0
MMGS2_k127_249425_146
TIGRFAM ATP-dependent helicase HrpA
K03578
-
3.6.4.13
0.0003133
43.0
MMGS2_k127_249425_147
chaperone-mediated protein complex assembly
-
-
-
0.0005734
46.0
MMGS2_k127_249425_15
COG2010 Cytochrome c, mono- and diheme variants
-
-
-
5.4e-323
989.0
MMGS2_k127_249425_16
PFAM Type II secretion system protein E
K02454
-
-
1.687e-316
974.0
MMGS2_k127_249425_17
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
-
-
-
5.509e-304
933.0
MMGS2_k127_249425_18
PFAM Cytochrome c assembly protein
-
-
-
9.247e-293
900.0
MMGS2_k127_249425_19
PFAM Major Facilitator Superfamily
K08218
-
-
1.091e-290
894.0
MMGS2_k127_249425_2
sucrose synthase
K00695
-
2.4.1.13
0.0
1605.0
MMGS2_k127_249425_20
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K00383
-
1.8.1.7
1.878e-282
869.0
MMGS2_k127_249425_21
TIGRFAM amidase, hydantoinase carbamoylase
K06016
-
3.5.1.6,3.5.1.87
3.808e-279
860.0
MMGS2_k127_249425_22
Radical SAM superfamily
K06139
-
-
7.264e-278
854.0
MMGS2_k127_249425_23
Major facilitator superfamily
-
-
-
2.485e-277
854.0
MMGS2_k127_249425_24
Belongs to the UPF0229 family
K09786
-
-
9.724e-265
820.0
MMGS2_k127_249425_25
Histidine kinase
K07637
-
2.7.13.3
7.018e-264
814.0
MMGS2_k127_249425_26
PFAM type I phosphodiesterase nucleotide pyrophosphatase
-
-
-
1.755e-259
806.0
MMGS2_k127_249425_27
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
2.728e-244
760.0
MMGS2_k127_249425_31
General secretion pathway protein F
K02455
-
-
4.422e-243
756.0
MMGS2_k127_249425_32
Belongs to the ATCase OTCase family
K00609
-
2.1.3.2
3.882e-232
719.0
MMGS2_k127_249425_33
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
K00652
-
2.3.1.47
2.451e-231
719.0
MMGS2_k127_249425_34
permease
K07089
-
-
3.834e-223
693.0
MMGS2_k127_249425_35
Cytochrome C oxidase, cbb3-type, subunit III
-
-
-
4.148e-222
690.0
MMGS2_k127_249425_36
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K01012
-
2.8.1.6
2.943e-220
684.0
MMGS2_k127_249425_37
Belongs to the peptidase S33 family
K01259
-
3.4.11.5
3.535e-216
670.0
MMGS2_k127_249425_38
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
1.23e-310
954.0
MMGS2_k127_2675234_1
Belongs to the ribulose-phosphate 3-epimerase family
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
2.602e-266
820.0
MMGS2_k127_2778689_15
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
2.338e-265
819.0
MMGS2_k127_2778689_16
Phosphate-selective porin O and P
-
-
-
7.799e-247
766.0
MMGS2_k127_2778689_17
response regulator receiver
K07814,K13815
-
-
4.661e-243
753.0
MMGS2_k127_2778689_18
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.000000000000000000000000000000000000000009938
153.0
MMGS2_k127_2948876_23
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.000000000000000000000000000000000000001309
148.0
MMGS2_k127_2948876_3
Diguanylate cyclase
-
-
-
0.0
1267.0
MMGS2_k127_2948876_4
TIGRFAM isocitrate dehydrogenase, NADP-dependent
K00031
-
1.1.1.42
1.878e-275
849.0
MMGS2_k127_2948876_5
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
6.568e-275
847.0
MMGS2_k127_2948876_6
Anthranilate synthase component I
K01657,K01665
-
2.6.1.85,4.1.3.27
9.821e-272
839.0
MMGS2_k127_2948876_7
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
1.859e-235
729.0
MMGS2_k127_2948876_8
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
K04044
-
-
0.0
1179.0
MMGS2_k127_308167_1
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
1.864e-295
908.0
MMGS2_k127_308167_10
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
K04488
-
-
0.00000000000005954
71.0
MMGS2_k127_308167_37
Protein of unknown function (DUF2938)
-
-
-
0.00000000003045
69.0
MMGS2_k127_308167_4
COG0477 Permeases of the major facilitator superfamily
-
-
-
1.849e-243
755.0
MMGS2_k127_308167_5
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K17713
-
-
5.823e-243
752.0
MMGS2_k127_308167_6
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
2.139e-237
736.0
MMGS2_k127_308167_7
Mandelate Racemase Muconate Lactonizing
K01781,K20023,K20549
-
4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25
1.958e-228
713.0
MMGS2_k127_308167_8
membrane-bound metal-dependent
K07038
-
-
2.12e-213
664.0
MMGS2_k127_308167_9
Domain of unknown function DUF21
-
-
-
4.53e-213
663.0
MMGS2_k127_3165915_0
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation
K00906
-
2.7.11.5
0.0
1186.0
MMGS2_k127_3261623_1
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
-
-
-
0.00000000000000000000000000000000000000000000358
163.0
MMGS2_k127_3315485_18
ATPase, P-type (transporting), HAD superfamily, subfamily IC
K01537
-
3.6.3.8
0.000000000001419
70.0
MMGS2_k127_3315485_19
TIGRFAM ATP-dependent helicase HrpA
K03578
-
3.6.4.13
0.00003241
48.0
MMGS2_k127_3315485_2
Chromate transporter
K07240
-
-
8.98e-293
900.0
MMGS2_k127_3315485_3
PFAM Major Facilitator Superfamily
K06902
-
-
1.207e-277
855.0
MMGS2_k127_3315485_4
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
K21071
-
2.7.1.11,2.7.1.90
3.393e-271
837.0
MMGS2_k127_3315485_5
Peptidase_C39 like family
-
-
-
4.876e-219
681.0
MMGS2_k127_3315485_6
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
The glycine cleavage system catalyzes the degradation of glycine
K00605
-
2.1.2.10
6.828e-230
712.0
MMGS2_k127_33196_12
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K18990
-
-
1.13e-210
657.0
MMGS2_k127_33196_13
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
2.573e-204
642.0
MMGS2_k127_33196_14
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00283
-
1.4.4.2
0.0
1002.0
MMGS2_k127_33196_5
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
1.958e-308
950.0
MMGS2_k127_33196_6
peptidase M24B, X-Pro dipeptidase aminopeptidase
K01262
-
3.4.11.9
1.058e-302
929.0
MMGS2_k127_33196_7
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1428.0
MMGS2_k127_3361692_2
RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K01595
-
4.1.1.31
0.0
1475.0
MMGS2_k127_344848_1
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
0.0
1145.0
MMGS2_k127_344848_10
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K02502
-
-
2.331e-251
777.0
MMGS2_k127_344848_11
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
1.358e-232
720.0
MMGS2_k127_344848_12
Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
K03666
-
-
0.0000000000000000000000000000000000000000006128
157.0
MMGS2_k127_344848_25
Uncharacterized protein conserved in bacteria (DUF2065)
K09937
-
-
0.000000000000000000000000000003156
120.0
MMGS2_k127_344848_26
NUDIX domain
K03574
-
3.6.1.55
0.000001791
50.0
MMGS2_k127_344848_3
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
8.356e-302
929.0
MMGS2_k127_344848_4
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
1.492e-295
908.0
MMGS2_k127_344848_5
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
5.111e-284
873.0
MMGS2_k127_344848_6
Cell wall hydrolase autolysin
K01448
-
3.5.1.28
8.319e-283
872.0
MMGS2_k127_344848_7
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
6.742e-269
829.0
MMGS2_k127_344848_8
PFAM Sodium sulphate symporter
K14445
-
-
7.126e-266
827.0
MMGS2_k127_344848_9
HflC and HflK could encode or regulate a protease
K04088
-
-
3.117e-263
812.0
MMGS2_k127_3463888_0
PFAM von Willebrand factor type A
K02448
-
-
0.0
1247.0
MMGS2_k127_3463888_1
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
7.645e-280
863.0
MMGS2_k127_3463888_3
CBS domain
-
-
-
1.486e-265
820.0
MMGS2_k127_3463888_4
PFAM Cytochrome c oxidase, subunit I
K04561
-
1.7.2.5
6.11e-254
783.0
MMGS2_k127_3463888_5
PFAM ATPase associated with various cellular activities
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
K04488
-
-
0.00000000000005954
71.0
MMGS2_k127_352742_2
Belongs to the glycosyl hydrolase 57 family
-
-
-
0.0
1153.0
MMGS2_k127_352742_3
PFAM glycoside hydrolase, family 77
K00705
-
2.4.1.25
0.0
1061.0
MMGS2_k127_352742_4
Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
8.708e-308
950.0
MMGS2_k127_3564883_1
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
6.645e-297
914.0
MMGS2_k127_3564883_10
TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.00000000000000000000000000000000000000001434
153.0
MMGS2_k127_3564883_19
Specifically methylates the ribose of guanosine 2251 in 23S rRNA
K03218
-
2.1.1.185
0.0000000000000000002587
87.0
MMGS2_k127_3564883_2
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
1.035e-296
911.0
MMGS2_k127_3564883_20
-
-
-
-
0.00000000000000004869
88.0
MMGS2_k127_3564883_3
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
2.091e-250
777.0
MMGS2_k127_3564883_4
Major Facilitator Superfamily
-
-
-
3.021e-250
778.0
MMGS2_k127_3564883_5
pfam mofrl
K11529
-
2.7.1.165
7.891e-243
754.0
MMGS2_k127_3564883_6
Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K01775
-
5.1.1.1
9.949e-219
685.0
MMGS2_k127_3564883_7
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PemK-like, MazF-like toxin of type II toxin-antitoxin system
K07171
-
-
0.000000000000000000000000000000000000000007658
160.0
MMGS2_k127_3569212_8
Pilin (bacterial filament)
-
-
-
0.000000000000000000000000000000000000002143
153.0
MMGS2_k127_3569212_9
addiction module antidote protein
-
-
-
0.00000000000000000000008836
101.0
MMGS2_k127_3627611_0
Hydrophobe Amphiphile Efflux-1 (HAE1)
K03296,K18138,K18299
-
-
0.0
2018.0
MMGS2_k127_3627611_1
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1885.0
MMGS2_k127_3627611_10
-
-
-
-
6.949e-245
757.0
MMGS2_k127_3627611_11
associated with various cellular activities
-
-
-
8.135e-230
712.0
MMGS2_k127_3627611_12
Trap-type c4-dicarboxylate transport system, periplasmic component
-
-
-
1.066e-227
709.0
MMGS2_k127_3627611_13
TIGRFAM RHS repeat-associated core domain
-
-
-
1.536e-226
732.0
MMGS2_k127_3627611_14
PFAM ABC transporter
-
-
-
5.481e-209
653.0
MMGS2_k127_3627611_15
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03040
-
2.7.7.6
1.54e-208
649.0
MMGS2_k127_3627611_16
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Belongs to the universal ribosomal protein uL29 family
K02904
-
-
0.0000000000000000000000000001161
116.0
MMGS2_k127_3627611_58
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.000000000000003885
76.0
MMGS2_k127_3627611_59
-
-
-
-
0.000002808
57.0
MMGS2_k127_3627611_6
PFAM Major Facilitator Superfamily
-
-
-
7.292e-273
843.0
MMGS2_k127_3627611_7
VWA-like domain (DUF2201)
-
-
-
8.021e-270
833.0
MMGS2_k127_3627611_8
Outer membrane efflux protein
-
-
-
1.098e-267
829.0
MMGS2_k127_3627611_9
Sigma-70, region 4
-
-
-
1.347e-265
826.0
MMGS2_k127_3647066_0
nitrous oxide reductase
K00376
-
1.7.2.4
0.0
1122.0
MMGS2_k127_3664523_0
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0
2464.0
MMGS2_k127_3664523_1
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0
1400.0
MMGS2_k127_3664523_2
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000000000000004871
92.0
MMGS2_k127_366527_0
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1405.0
MMGS2_k127_366527_1
Part of a membrane complex involved in electron transport
K03615
-
-
0.0
1048.0
MMGS2_k127_366527_2
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
1.409e-302
929.0
MMGS2_k127_3679634_3
PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
-
-
-
1.759e-273
843.0
MMGS2_k127_3679634_4
Major facilitator superfamily
K05820
-
-
5.422e-244
756.0
MMGS2_k127_3679634_5
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
6.781e-240
743.0
MMGS2_k127_3679634_6
TIGRFAM lysine 2,3-aminomutase YodO family protein
K01843,K19810
-
5.4.3.2
4.202e-217
676.0
MMGS2_k127_3679634_7
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue
K07320
-
2.1.1.298
6.591e-194
609.0
MMGS2_k127_3679634_8
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses
K01916,K01950
-
6.3.1.5,6.3.5.1
5.377e-221
698.0
MMGS2_k127_3725209_1
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2279.0
MMGS2_k127_372998_1
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1535.0
MMGS2_k127_372998_10
PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
0.0
1122.0
MMGS2_k127_372998_31
Protein of unknown function (DUF2892)
-
-
-
0.000000000000000000000000000000000000886
139.0
MMGS2_k127_372998_32
Belongs to the UPF0434 family
K09791
-
-
0.00000000000000000000000000000000002787
134.0
MMGS2_k127_372998_33
diguanylate cyclase
-
-
-
0.000000000000000001188
89.0
MMGS2_k127_372998_34
hydrolases or acyltransferases, alpha beta hydrolase superfamily
-
-
-
0.0000000005708
62.0
MMGS2_k127_372998_35
protein phosphatase 2C domain protein
-
-
-
0.0001375
50.0
MMGS2_k127_372998_4
lipoprotein releasing system, transmembrane protein, LolC E family
K09808
-
-
1.876e-252
781.0
MMGS2_k127_372998_5
Mediates influx of magnesium ions
K03284
-
-
2.738e-229
710.0
MMGS2_k127_372998_6
Belongs to the agmatine deiminase family
-
-
-
1.977e-217
677.0
MMGS2_k127_372998_7
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
K00912
-
2.7.1.130
5.785e-211
659.0
MMGS2_k127_372998_8
Responsible for synthesis of pseudouridine from uracil
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
1.771e-254
787.0
MMGS2_k127_3767000_3
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K09001
-
2.7.1.170
9.729e-228
709.0
MMGS2_k127_3767000_4
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K00937
-
2.7.4.1
0.0
1362.0
MMGS2_k127_3825573_1
Asparagine synthase, glutamine-hydrolyzing
K01953
-
6.3.5.4
0.0
1189.0
MMGS2_k127_3825573_10
PFAM phosphate transporter
K03306
-
-
2.127e-253
785.0
MMGS2_k127_3825573_11
PFAM Aminotransferase class-III
K00821
-
2.6.1.11,2.6.1.17
3.49e-247
767.0
MMGS2_k127_3825573_12
Methyltransferase
K18911
-
2.1.1.44
1.276e-201
633.0
MMGS2_k127_3825573_13
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
5.31e-265
826.0
MMGS2_k127_3985183_9
DNA polymerase III, delta subunit
K02340
-
2.7.7.7
6.239e-212
660.0
MMGS2_k127_3993638_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1588.0
MMGS2_k127_3993638_1
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
K03495
-
-
0.0
1185.0
MMGS2_k127_3993638_10
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
1.269e-206
647.0
MMGS2_k127_3993638_11
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
K00820
-
2.6.1.16
0.0
1069.0
MMGS2_k127_3993638_4
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
8.909e-320
981.0
MMGS2_k127_3993638_5
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
1.986e-293
901.0
MMGS2_k127_3993638_6
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
2.208e-283
872.0
MMGS2_k127_3993638_7
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
2.271e-280
864.0
MMGS2_k127_3993638_8
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
6.639e-264
816.0
MMGS2_k127_3993638_9
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
1.193e-223
695.0
MMGS2_k127_4028933_0
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle
K01596
-
4.1.1.32
0.0
1293.0
MMGS2_k127_4028933_1
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1151.0
MMGS2_k127_4030506_6
Circularly permuted ATP-grasp type 2
-
-
-
7e-323
988.0
MMGS2_k127_4030506_7
DNA polymerase III
K02342
-
2.7.7.7
1.33e-311
969.0
MMGS2_k127_4030506_8
PFAM Aldehyde dehydrogenase
K00135
-
1.2.1.16,1.2.1.20,1.2.1.79
1.96e-285
878.0
MMGS2_k127_4030506_9
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
K00974
-
2.7.7.72
5.358e-260
814.0
MMGS2_k127_4074959_0
The glycine cleavage system catalyzes the degradation of glycine
-
-
-
0.0
1860.0
MMGS2_k127_4074959_1
PFAM glycosyl transferase family 39
-
-
-
0.0
1011.0
MMGS2_k127_4074959_10
Sarcosine oxidase, subunit beta
K00303
-
1.5.3.1
1.388e-263
829.0
MMGS2_k127_4074959_11
Ammonium transporter
K03320
-
-
8.836e-260
802.0
MMGS2_k127_4074959_12
PFAM Glucose Sorbosone dehydrogenase
K21430
-
-
4.329e-243
752.0
MMGS2_k127_4074959_13
PFAM Glycosyl transferase family 2
-
-
-
3.79e-223
695.0
MMGS2_k127_4074959_14
COG1943 Transposase and inactivated derivatives
-
-
-
1.15e-215
671.0
MMGS2_k127_4074959_15
Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Belongs to the Glu Leu Phe Val dehydrogenases family
K00262
-
1.4.1.4
5.126e-296
908.0
MMGS2_k127_4074959_8
Belongs to the glutamate synthase family
K00265,K22083
-
1.4.1.13,1.4.1.14,2.1.1.21
4.554e-289
892.0
MMGS2_k127_4074959_9
Mo-co oxidoreductase dimerisation domain
K17225
-
-
6.943e-270
833.0
MMGS2_k127_4085382_0
Belongs to the heme-copper respiratory oxidase family
-
-
-
1.139e-252
784.0
MMGS2_k127_4085382_1
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
2524.0
MMGS2_k127_4369725_1
synthetase
K01908
-
6.2.1.17
0.0
1320.0
MMGS2_k127_4369725_10
-
-
-
-
1.339e-255
790.0
MMGS2_k127_4369725_11
Belongs to the citrate synthase family
K01659
-
2.3.3.5
1.794e-255
790.0
MMGS2_k127_4369725_12
desaturase
K00507
-
1.14.19.1
1.838e-248
767.0
MMGS2_k127_4369725_13
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
-
-
-
1.586e-233
723.0
MMGS2_k127_4369725_14
transferase activity, transferring glycosyl groups
-
-
-
5.523e-232
720.0
MMGS2_k127_4369725_15
transferase activity, transferring glycosyl groups
K07011
-
-
9.471e-231
717.0
MMGS2_k127_4369725_16
-
-
-
-
2.214e-225
699.0
MMGS2_k127_4369725_17
PFAM Glycosyl transferase, group 1
K12994
-
2.4.1.349
6.458e-221
690.0
MMGS2_k127_4369725_18
Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K01711
-
4.2.1.47
3.113e-220
685.0
MMGS2_k127_4369725_19
N-terminal domain of oxidoreductase
K00344
-
1.6.5.5
1.585e-210
660.0
MMGS2_k127_4369725_2
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase
K14162
-
2.7.7.7
0.0
1183.0
MMGS2_k127_4369725_20
PFAM Alcohol dehydrogenase
K19745
-
-
2.103e-210
654.0
MMGS2_k127_4369725_21
Metallo-beta-lactamase superfamily
-
-
-
1.444e-204
638.0
MMGS2_k127_4369725_22
TRAP transporter, solute receptor (TAXI family
-
-
-
6.996e-203
634.0
MMGS2_k127_4369725_23
PFAM Transposase IS200 like
-
-
-
1.314e-202
631.0
MMGS2_k127_4369725_24
Sulfatase
-
-
-
9.024e-202
651.0
MMGS2_k127_4369725_25
Cytochrome c554 and c-prime
-
-
-
7.038e-195
632.0
MMGS2_k127_4369725_26
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site
Belongs to the mannose-6-phosphate isomerase type 2 family
K00971,K16011
-
2.7.7.13,5.3.1.8
1.331e-293
904.0
MMGS2_k127_4369725_8
Belongs to the mannose-6-phosphate isomerase type 2 family
K00971,K16011
-
2.7.7.13,5.3.1.8
1.265e-288
889.0
MMGS2_k127_4369725_9
-
-
-
-
7.434e-287
883.0
MMGS2_k127_448220_0
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
1.669e-238
740.0
MMGS2_k127_448220_1
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
1.938e-200
627.0
MMGS2_k127_448220_2
Thiamine monophosphate synthase
K03574
-
3.6.1.55
0.0000000000002695
73.0
MMGS2_k127_457623_0
type IV pilus secretin PilQ
K02666
-
-
0.0
1220.0
MMGS2_k127_463120_0
ATPase, P-type (transporting), HAD superfamily, subfamily IC
K01533
-
3.6.3.4
0.0
1600.0
MMGS2_k127_463120_1
TIGRFAM penicillin-binding protein, 1A
K05366
-
2.4.1.129,3.4.16.4
0.0
1580.0
MMGS2_k127_463120_10
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
2.13e-250
775.0
MMGS2_k127_463120_11
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02275
-
1.9.3.1
6.908e-240
742.0
MMGS2_k127_463120_12
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K01409
-
2.3.1.234
1.042e-206
644.0
MMGS2_k127_463120_18
Catalyzes the reversible oxidation of malate to oxaloacetate
K00024
-
1.1.1.37
2.915e-206
644.0
MMGS2_k127_463120_19
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
K00406
-
-
2.491e-205
639.0
MMGS2_k127_463120_2
PFAM Lytic
K08309
-
-
0.0
1334.0
MMGS2_k127_463120_20
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03110
-
-
2.689e-200
625.0
MMGS2_k127_463120_21
PFAM cytochrome c oxidase, subunit III
K02276
-
1.9.3.1
1.482e-196
613.0
MMGS2_k127_463120_22
5'-3' exonuclease
-
-
-
6.108e-196
615.0
MMGS2_k127_463120_23
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1812.0
MMGS2_k127_4640223_1
Diguanylate cyclase
-
-
-
0.0
1200.0
MMGS2_k127_4640223_10
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
7.76e-260
802.0
MMGS2_k127_4640223_5
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
-
-
-
4.553e-227
708.0
MMGS2_k127_4640223_6
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
K01465
-
3.5.2.3
9.674e-223
691.0
MMGS2_k127_4640223_7
WYL domain
-
-
-
7.301e-195
613.0
MMGS2_k127_4640223_8
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PFAM binding-protein-dependent transport systems inner membrane component
K02037
-
-
0.0
1327.0
MMGS2_k127_4680684_10
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K06001
-
4.2.1.20
1.323e-298
919.0
MMGS2_k127_4680684_11
Belongs to the glutamate synthase family
K00265
-
1.4.1.13,1.4.1.14
2.371e-297
915.0
MMGS2_k127_4680684_12
Histidine kinase
K07636
-
2.7.13.3
1.494e-277
854.0
MMGS2_k127_4680684_13
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Belongs to the acetyltransferase family. ArgA subfamily
K14682
-
2.3.1.1
2.379e-276
852.0
MMGS2_k127_4680684_15
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
3.503e-272
841.0
MMGS2_k127_4680684_16
Major Facilitator Superfamily
-
-
-
9.729e-255
793.0
MMGS2_k127_4680684_17
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
K01768
-
4.6.1.1
2.01e-247
767.0
MMGS2_k127_4680684_18
Belongs to the peptidase M20A family. ArgE subfamily
K01438
-
3.5.1.16
6.109e-242
750.0
MMGS2_k127_4680684_19
PFAM GCN5-related N-acetyltransferase
-
-
-
2.53e-241
747.0
MMGS2_k127_4680684_2
Belongs to the IlvD Edd family
K01687
-
4.2.1.9
0.0
1227.0
MMGS2_k127_4680684_20
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K03684
-
3.1.13.5
3.058e-238
741.0
MMGS2_k127_4680684_21
Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine
K00651
-
2.3.1.46
7.912e-236
732.0
MMGS2_k127_4680684_22
Phosphotransferase enzyme family
K07102
-
2.7.1.221
5.18e-226
702.0
MMGS2_k127_4680684_23
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
2.752e-223
695.0
MMGS2_k127_4680684_24
TIGRFAM Cell shape determining protein MreB Mrl
K03569
-
-
1.144e-220
685.0
MMGS2_k127_4680684_25
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
3.633e-220
692.0
MMGS2_k127_4680684_26
Elongator protein 3, MiaB family, Radical SAM
-
-
-
6.338e-212
661.0
MMGS2_k127_4680684_27
TIGRFAM phosphate binding protein
K02040
-
-
3.882e-205
645.0
MMGS2_k127_4680684_28
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K00948
-
2.7.6.1
2.088e-195
611.0
MMGS2_k127_4680684_29
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
4.275e-309
949.0
MMGS2_k127_4680684_9
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
6.454e-306
939.0
MMGS2_k127_4870966_6
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
5.028e-271
839.0
MMGS2_k127_4870966_7
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
0.000000000001568
66.0
MMGS2_k127_5020313_4
cytochrome p450
-
-
-
0.00007403
48.0
MMGS2_k127_5110290_0
PFAM AsmA family protein
K07289
-
-
0.0
1301.0
MMGS2_k127_5110290_1
Belongs to the peptidase S1C family
K04771,K04772
-
3.4.21.107
3.959e-270
835.0
MMGS2_k127_5110290_10
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K03636
-
-
0.00000000000000000000000000000000000000000001742
161.0
MMGS2_k127_5110290_14
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1891.0
MMGS2_k127_5198785_1
CoA-binding domain protein
K09181
-
-
0.0
1700.0
MMGS2_k127_5198785_10
NMT1-like family
K15576
-
-
1.842e-317
971.0
MMGS2_k127_5198785_11
Flavocytochrome c sulphide dehydrogenase, flavin-binding
K17229
-
1.8.2.3
5.377e-283
871.0
MMGS2_k127_5198785_12
response regulator
-
-
-
2.932e-282
871.0
MMGS2_k127_5198785_13
PFAM membrane protein involved in aromatic hydrocarbon degradation
K06076
-
-
6.404e-274
846.0
MMGS2_k127_5198785_14
COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain
-
-
-
2.409e-252
779.0
MMGS2_k127_5198785_15
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
5.077e-232
719.0
MMGS2_k127_5198785_17
PFAM Alcohol dehydrogenase
K00344
-
1.6.5.5
2.641e-213
666.0
MMGS2_k127_5198785_18
Ethylbenzene dehydrogenase
-
-
-
7.177e-204
636.0
MMGS2_k127_5198785_19
PFAM Histone deacetylase
-
-
-
1.924e-201
627.0
MMGS2_k127_5198785_2
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
-
-
-
0.0
1336.0
MMGS2_k127_5198785_20
Doubled CXXCH motif (Paired_CXXCH_1)
-
-
-
1.746e-199
624.0
MMGS2_k127_5198785_21
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.922e-318
977.0
MMGS2_k127_5202328_0
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1298.0
MMGS2_k127_5326171_1
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
Belongs to the SOS response-associated peptidase family
-
-
-
0.0000000000000464
78.0
MMGS2_k127_5326171_26
Resolvase
-
-
-
0.0003521
45.0
MMGS2_k127_5326171_3
phosphate-selective porin O and P
-
-
-
2.392e-296
914.0
MMGS2_k127_5326171_4
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K00796
-
2.5.1.15
5.267e-276
853.0
MMGS2_k127_5326171_5
4Fe-4S ferredoxin iron-sulfur binding domain protein
K11473
-
-
1.505e-272
843.0
MMGS2_k127_5326171_6
PFAM Aminotransferase class I and II
K00812
-
2.6.1.1
1.455e-251
779.0
MMGS2_k127_5326171_7
PFAM ErfK YbiS YcfS YnhG family protein
K16291
-
-
1.065e-241
751.0
MMGS2_k127_5326171_8
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
K00688
-
2.4.1.1
0.0
1649.0
MMGS2_k127_5374710_1
Bifunctional purine biosynthesis protein PurH
K00602
-
2.1.2.3,3.5.4.10
0.0
1022.0
MMGS2_k127_5374710_10
alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
8.939e-240
741.0
MMGS2_k127_5374710_5
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Required for chromosome condensation and partitioning
K03529
-
-
0.0
2125.0
MMGS2_k127_5478004_1
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K01251
-
3.3.1.1
8.353e-308
945.0
MMGS2_k127_5567843_4
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
6.974e-277
856.0
MMGS2_k127_5567843_5
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
9.795e-242
751.0
MMGS2_k127_5567843_6
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
9.747e-239
741.0
MMGS2_k127_5567843_7
Fructose-bisphosphate aldolase, class II, Calvin cycle subtype
K01624
-
4.1.2.13
3.034e-225
698.0
MMGS2_k127_5567843_8
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
1.771e-211
657.0
MMGS2_k127_5567843_9
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
1.364e-207
661.0
MMGS2_k127_5568185_0
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
K02224
-
6.3.5.11,6.3.5.9
2.749e-288
889.0
MMGS2_k127_5568185_11
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
6.481e-285
878.0
MMGS2_k127_5568185_12
reductase, dissimilatory-type alpha subunit
K11180
-
1.8.99.5
2.489e-279
862.0
MMGS2_k127_5568185_13
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1002.0
MMGS2_k127_5568185_70
Belongs to the TPP enzyme family
K03852
-
2.3.3.15
0.000000000000009866
75.0
MMGS2_k127_5568185_71
DsrE/DsrF-like family
K07092
-
-
0.00000000008278
70.0
MMGS2_k127_5568185_72
Domain of unknown function (DUF4405)
K00127
-
-
0.0000000001848
63.0
MMGS2_k127_5568185_73
formate dehydrogenase
K00124
-
-
0.00000000062
64.0
MMGS2_k127_5568185_74
Elongation factor SelB, winged helix
K03833
-
-
0.00000006143
59.0
MMGS2_k127_5568185_75
Prokaryotic cytochrome b561
-
-
-
0.0000008214
53.0
MMGS2_k127_5568185_8
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
8.711e-319
977.0
MMGS2_k127_5568185_9
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0
1170.0
MMGS2_k127_5581995_30
ParE toxin of type II toxin-antitoxin system, parDE
-
-
-
0.0000000000000000000000000000003612
127.0
MMGS2_k127_5581995_31
Glutaredoxin-like domain (DUF836)
-
-
-
0.000000000000000144
81.0
MMGS2_k127_5581995_32
-
-
-
-
0.0000000000000002448
80.0
MMGS2_k127_5581995_4
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
0.0
1073.0
MMGS2_k127_5581995_5
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
2.077e-320
984.0
MMGS2_k127_5581995_6
Belongs to the peptidase S1C family
K04771
-
3.4.21.107
3.173e-303
931.0
MMGS2_k127_5581995_7
PFAM binding-protein-dependent transport systems inner membrane component
4Fe-4S ferredoxin iron-sulfur binding domain protein
K11473
-
-
1.142e-249
774.0
MMGS2_k127_588620_1
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K00766
-
2.4.2.18
2.142e-203
635.0
MMGS2_k127_588620_10
Belongs to the universal ribosomal protein uS9 family
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
1.254e-312
960.0
MMGS2_k127_669593_12
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
2.713e-309
947.0
MMGS2_k127_669593_13
Belongs to the MurCDEF family
K01924
-
6.3.2.8
7.607e-304
940.0
MMGS2_k127_669593_14
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
1.539e-300
924.0
MMGS2_k127_669593_15
PFAM FAD linked oxidase domain protein
K03777
-
1.1.5.12
6.021e-291
897.0
MMGS2_k127_669593_16
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
3.309e-288
890.0
MMGS2_k127_669593_17
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
1.534e-273
848.0
MMGS2_k127_669593_18
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
5.413e-266
822.0
MMGS2_k127_669593_19
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
5.01e-264
816.0
MMGS2_k127_669593_2
serine threonine protein kinase
K12132
-
2.7.11.1
0.0
1657.0
MMGS2_k127_669593_20
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.281e-262
812.0
MMGS2_k127_669593_21
Glutathione S-Transferase
K07393
-
1.8.5.7
2.113e-254
785.0
MMGS2_k127_669593_22
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
2.023e-251
788.0
MMGS2_k127_669593_23
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
8.439e-241
745.0
MMGS2_k127_669593_24
Trypsin
K04691
-
-
2.005e-237
737.0
MMGS2_k127_669593_25
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
5.144e-236
734.0
MMGS2_k127_669593_26
Luciferase-like monooxygenase
K00494
-
1.14.14.3
1.128e-234
729.0
MMGS2_k127_669593_27
Protein of unknown function, DUF484
-
-
-
3.961e-229
712.0
MMGS2_k127_669593_28
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
3.034e-225
698.0
MMGS2_k127_669593_29
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
6.321e-225
698.0
MMGS2_k127_669593_3
HAD-superfamily hydrolase, subfamily IIB
K00696
-
2.4.1.14
0.0
1453.0
MMGS2_k127_669593_30
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
2.477e-213
665.0
MMGS2_k127_669593_31
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K02563
-
2.4.1.227
2.511e-211
671.0
MMGS2_k127_669593_32
Arabinose 5-phosphate isomerase
K06041
-
5.3.1.13
2.552e-200
627.0
MMGS2_k127_669593_33
Belongs to the D-alanine--D-alanine ligase family
K01921
-
6.3.2.4
7.298e-198
617.0
MMGS2_k127_669593_34
Pyridine nucleotide-disulphide oxidoreductase
K00362,K05297
-
1.18.1.1,1.7.1.15
3.113e-196
619.0
MMGS2_k127_669593_35
Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
K01919
-
6.3.2.2
0.0
1036.0
MMGS2_k127_712664_0
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation
-
-
-
0.000000000000007674
86.0
MMGS2_k127_714204_5
-
K06039
-
-
0.00000000000004765
74.0
MMGS2_k127_714204_6
-
-
-
-
0.0000000000003016
71.0
MMGS2_k127_730768_0
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
2125.0
MMGS2_k127_730768_1
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K21307
-
1.8.5.6
0.0
1952.0
MMGS2_k127_730768_10
Heat shock 70 kDa protein
K04043
-
-
0.0
1212.0
MMGS2_k127_730768_11
peptidylprolyl isomerase
K03770
-
5.2.1.8
0.0
1174.0
MMGS2_k127_730768_12
lytic transglycosylase
K08307
-
-
0.0
1110.0
MMGS2_k127_730768_13
Belongs to the ABC transporter superfamily
K02031,K02032,K13896
-
-
0.0
1058.0
MMGS2_k127_730768_14
May be involved in recombinational repair of damaged DNA
K03631
-
-
0.0
1017.0
MMGS2_k127_730768_15
TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M
K00342
-
1.6.5.3
8.362e-320
980.0
MMGS2_k127_730768_16
Participates in both transcription termination and antitermination
K02600
-
-
6.22e-309
949.0
MMGS2_k127_730768_17
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
2.283e-289
891.0
MMGS2_k127_730768_18
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K00335
-
1.6.5.3
4.687e-287
883.0
MMGS2_k127_730768_19
PFAM binding-protein-dependent transport systems inner membrane component
K02033
-
-
1.912e-282
870.0
MMGS2_k127_730768_2
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1575.0
MMGS2_k127_730768_20
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
2.727e-281
865.0
MMGS2_k127_730768_21
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
4.837e-273
841.0
MMGS2_k127_730768_22
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
4.719e-267
825.0
MMGS2_k127_730768_23
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
K03308
-
-
6.071e-267
827.0
MMGS2_k127_730768_24
Belongs to the sulfate adenylyltransferase family
K00958
-
2.7.7.4
1.894e-256
791.0
MMGS2_k127_730768_25
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K00337
-
1.6.5.3
5.119e-228
709.0
MMGS2_k127_730768_28
Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
K03705
-
-
1.43e-214
668.0
MMGS2_k127_730768_29
COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components
K02034
-
-
2.548e-198
623.0
MMGS2_k127_730768_3
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1540.0
MMGS2_k127_730768_30
PFAM DMSO reductase anchor subunit (DmsC)
K21309
-
-
2.837e-196
619.0
MMGS2_k127_730768_31
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.0
1248.0
MMGS2_k127_730768_80
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Bacterial extracellular solute-binding proteins, family 5 Middle
K02035
-
-
0.0
1228.0
MMGS2_k127_730768_90
-
-
-
-
0.00000415
51.0
MMGS2_k127_730768_92
Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00331,K03940
-
1.6.5.3,1.6.99.3
0.0001056
46.0
MMGS2_k127_776365_0
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
protein related to plant photosystem II stability assembly factor
-
-
-
1.453e-251
777.0
MMGS2_k127_776365_3
Putative methyltransferase
-
-
-
8.121e-227
704.0
MMGS2_k127_776365_4
helix_turn_helix, arabinose operon control protein
-
-
-
8.426e-217
674.0
MMGS2_k127_776365_5
NmrA-like family
-
-
-
1.104e-196
620.0
MMGS2_k127_776365_6
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1461.0
MMGS2_k127_791189_20
Diguanylate cyclase
-
-
-
0.0004605
44.0
MMGS2_k127_791189_3
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1417.0
MMGS2_k127_791189_4
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1260.0
MMGS2_k127_791189_5
Tripartite tricarboxylate transporter TctA
K07793
-
-
1.517e-304
936.0
MMGS2_k127_791189_6
-
-
-
-
1.927e-301
930.0
MMGS2_k127_791189_7
Belongs to the mandelate racemase muconate lactonizing enzyme family
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1589.0
MMGS2_k127_810690_1
signal transduction histidine kinase
-
-
-
0.0
1382.0
MMGS2_k127_810690_10
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.0000004663
51.0
MMGS2_k127_814924_2
Belongs to the 'phage' integrase family
-
-
-
3.085e-277
856.0
MMGS2_k127_814924_3
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
2.428e-242
750.0
MMGS2_k127_814924_4
Peptidoglycan polymerase that is essential for cell wall elongation
K05837
-
-
2.229e-218
682.0
MMGS2_k127_814924_5
Lytic murein transglycosylase B
K08305
-
-
2.521e-217
679.0
MMGS2_k127_814924_6
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K00097
-
1.1.1.262
9.24e-213
662.0
MMGS2_k127_814924_7
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
K00939
-
2.7.4.3
2.577e-199
637.0
MMGS2_k127_814924_8
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
0.000000000000000004231
91.0
MMGS2_k127_878727_3
alpha beta alpha domain I
K01835
-
5.4.2.2
0.0
1059.0
MMGS2_k127_878727_4
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
0.0
1007.0
MMGS2_k127_878727_5
Major facilitator superfamily
K08224
-
-
2.596e-230
721.0
MMGS2_k127_878727_6
HlyD family secretion protein
K02005
-
-
6.19e-228
709.0
MMGS2_k127_878727_7
Belongs to the GcvT family
K06980
-
-
1.674e-222
698.0
MMGS2_k127_878727_8
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K02836
-
-
5.985e-209
651.0
MMGS2_k127_878727_9
TRAP transporter, solute receptor (TAXI family
K07080
-
-
1.485e-208
650.0
MMGS2_k127_931611_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
2072.0
MMGS2_k127_931611_1
Protein of unknown function (DUF1631)
-
-
-
0.0
1428.0
MMGS2_k127_931611_10
Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.0
1156.0
MMGS2_k127_931611_20
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Belongs to the SOS response-associated peptidase family
-
-
-
0.00000000000001024
78.0
MMGS2_k127_931611_3
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1109.0
MMGS2_k127_931611_31
-
-
-
-
0.0002999
44.0
MMGS2_k127_931611_4
Involved in the TonB-independent uptake of proteins
K03641
-
-
6.527e-281
864.0
MMGS2_k127_931611_5
Sulphur transport
K07112
-
-
2.941e-269
831.0
MMGS2_k127_931611_6
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
1.155e-216
674.0
MMGS2_k127_931611_7
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
3.668e-205
642.0
MMGS2_k127_931611_8
Belongs to the short-chain dehydrogenases reductases (SDR) family
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells
