Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ParE toxin of type II toxin-antitoxin system, parDE
K06218
-
-
0.00000000000000000000000000003174
118.0
MMGS3_k127_1106037_14
-
-
-
-
0.000000000000000000002101
98.0
MMGS3_k127_1106037_15
Cro/C1-type HTH DNA-binding domain
-
-
-
0.00000000000827
66.0
MMGS3_k127_1106037_16
Archaeal Type IV pilin, N-terminal
-
-
-
0.0000001653
64.0
MMGS3_k127_1106037_17
Putative transposase
-
-
-
0.0000007311
57.0
MMGS3_k127_1106037_18
Transport and Golgi organisation 2
-
-
-
0.00001096
50.0
MMGS3_k127_1106037_2
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
1.232e-207
651.0
MMGS3_k127_1132500_20
Heavy-metal resistance protein CzcE
-
-
-
0.0000000000000003769
83.0
MMGS3_k127_1132500_21
Transposase
-
-
-
0.0000000001102
61.0
MMGS3_k127_1132500_3
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0000000000000000000000000000000000005833
151.0
MMGS3_k127_1202207_21
cytoplasmic domain of flagellar protein
K04061
-
-
0.00000000000000000000000000002838
134.0
MMGS3_k127_1202207_22
Acetyltransferase (GNAT) domain
-
-
-
0.0000000000000000000000000000437
123.0
MMGS3_k127_1202207_23
Belongs to the sulfur carrier protein TusA family
K04085
-
-
0.000000000000000000000000002431
113.0
MMGS3_k127_1202207_25
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.000000000000000005611
88.0
MMGS3_k127_1202207_26
Bacterial transferase hexapeptide (six repeats)
-
-
-
0.000000000001483
71.0
MMGS3_k127_1202207_3
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
1.535e-200
643.0
MMGS3_k127_1202207_4
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K03737
-
1.2.7.1
0.0
1931.0
MMGS3_k127_1226098_1
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K00700
-
2.4.1.18
0.0
1207.0
MMGS3_k127_1226098_10
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
1.615e-224
704.0
MMGS3_k127_1226098_11
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
-
-
-
0.0000000000000000000000000000000000000007883
169.0
MMGS3_k127_1226098_39
Belongs to the ompA family
K03286
-
-
0.00000000000000000000000000000000000009869
149.0
MMGS3_k127_1226098_4
ABC transporter
-
-
-
0.0
1015.0
MMGS3_k127_1226098_40
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
K03666
-
-
0.000000000000000000000000000000001703
131.0
MMGS3_k127_1226098_41
Histidine kinase
K07652
-
2.7.13.3
0.000000000000000000000000000009317
135.0
MMGS3_k127_1226098_42
repeat-containing protein
-
-
-
0.00000000000000000000000000005428
127.0
MMGS3_k127_1226098_43
Histidine kinase
-
-
-
0.0000000000000000000000000000756
134.0
MMGS3_k127_1226098_44
phosphorelay signal transduction system
-
-
-
0.00000000000000000009854
94.0
MMGS3_k127_1226098_45
Uncharacterized protein conserved in bacteria (DUF2065)
K09937
-
-
0.0000000000000000001014
89.0
MMGS3_k127_1226098_46
Hydrogenase maturation protease
K03605
-
-
0.0000000000000001329
87.0
MMGS3_k127_1226098_49
protein conserved in bacteria
K09858
-
-
0.000001985
59.0
MMGS3_k127_1226098_5
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K02837
-
-
1.635e-298
922.0
MMGS3_k127_1226098_50
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
-
-
-
0.00005964
49.0
MMGS3_k127_1226098_6
glutamate synthase
-
-
-
1.115e-292
910.0
MMGS3_k127_1226098_7
Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K00975
-
2.7.7.27
1.627e-242
754.0
MMGS3_k127_1226098_8
Belongs to the glycosyl hydrolase 57 family
-
-
-
6.812e-242
760.0
MMGS3_k127_1226098_9
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K00362
-
1.7.1.15
0.0
1047.0
MMGS3_k127_1336822_10
Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)
-
-
-
2.246e-212
689.0
MMGS3_k127_1336822_11
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
(sprot CYCP_CHRVI). CYTOCHROME C IS THE MOST WIDELY OCCURRING BACTERIAL C-TYPE CYTOCHROME. CYTOCHROMES C ARE HIGH-SPIN PROTEINS AND THE HEME HAS NO SIXTH LIGAND. THEIR EXACT FUNCTION IS NOT KNOWN
Belongs to the V-ATPase proteolipid subunit family
K02124
-
-
0.00000000000000000000000005029
113.0
MMGS3_k127_1336822_61
-
-
-
-
0.00000000000000000000000005533
116.0
MMGS3_k127_1336822_62
ATP synthase subunit D
K02120
-
-
0.0000000000000000000008934
104.0
MMGS3_k127_1336822_63
-
-
-
-
0.0000000000000000007895
88.0
MMGS3_k127_1336822_64
-
-
-
-
0.000000000000003115
83.0
MMGS3_k127_1336822_65
-
-
-
-
0.000000000000006221
84.0
MMGS3_k127_1336822_66
Subunit R is required for both nuclease and ATPase activities, but not for modification
K01153
-
3.1.21.3
0.000000009094
61.0
MMGS3_k127_1336822_67
ATP synthase (F/14-kDa) subunit
-
-
-
0.00005216
52.0
MMGS3_k127_1336822_7
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
4.368e-232
724.0
MMGS3_k127_1336822_8
TIGRFAM Tryptophanyl-tRNA synthetase
K01867
-
6.1.1.2
1.925e-228
711.0
MMGS3_k127_1336822_9
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
9.242e-221
691.0
MMGS3_k127_1389329_0
(ABC) transporter
-
-
-
5.21e-233
760.0
MMGS3_k127_1389329_1
Belongs to the mannose-6-phosphate isomerase type 2 family
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
1628.0
MMGS3_k127_1751978_1
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0
1177.0
MMGS3_k127_1795856_1
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
K00688
-
2.4.1.1
0.0
1086.0
MMGS3_k127_1795856_10
Transfers the fatty acyl group on membrane lipoproteins
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PFAM peptidase M3A and M3B, thimet oligopeptidase F
K01414
-
3.4.24.70
4.728e-302
947.0
MMGS3_k127_1795856_20
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
PemK-like, MazF-like toxin of type II toxin-antitoxin system
K07171
-
-
0.0000000000000000000000000000000000000000446
154.0
MMGS3_k127_1795856_27
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K07042
-
-
0.0000000000000000000000000000000000000001805
162.0
MMGS3_k127_1795856_28
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K03643
-
-
0.0000000000000000000000000000003104
135.0
MMGS3_k127_1795856_29
-
-
-
-
0.0000000000000000000000000001415
119.0
MMGS3_k127_1795856_3
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
6.815e-289
900.0
MMGS3_k127_1795856_30
antitoxin
K07172
-
-
0.0000000000000000000021
96.0
MMGS3_k127_1795856_31
transcriptional regulator, XRE family
-
-
-
0.000000000000002489
79.0
MMGS3_k127_1795856_4
Sodium:sulfate symporter transmembrane region
-
-
-
1.719e-261
819.0
MMGS3_k127_1795856_5
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01950
-
6.3.5.1
8.07e-243
760.0
MMGS3_k127_1795856_6
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
6.54e-234
732.0
MMGS3_k127_1795856_7
GGDEF domain
-
-
-
1.823e-232
743.0
MMGS3_k127_1795856_8
Belongs to the GARS family
K01945
-
6.3.4.13
1.42e-209
659.0
MMGS3_k127_1795856_9
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
2.351e-286
889.0
MMGS3_k127_1863135_10
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1275.0
MMGS3_k127_1919004_1
ABC-Type Dipeptide Transport System Periplasmic Component
K02035,K13889
-
-
4.106e-291
905.0
MMGS3_k127_1919004_10
-
-
-
-
0.000000000000000001559
88.0
MMGS3_k127_1919004_12
-
-
-
-
0.00001158
48.0
MMGS3_k127_1919004_2
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
1.582e-230
718.0
MMGS3_k127_1919004_3
May be involved in recombinational repair of damaged DNA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530
-
-
0.000000000000000000000000000000137
127.0
MMGS3_k127_1930909_0
PFAM ABC transporter
K06158
-
-
3.059e-218
694.0
MMGS3_k127_1930909_1
PFAM Type II secretion system protein E
K02454
-
-
1.064e-214
679.0
MMGS3_k127_1930909_10
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
COG0810 Periplasmic protein TonB links inner and outer membranes
K03646
-
-
0.0000000000000000008254
96.0
MMGS3_k127_1979932_68
-
-
-
-
0.00000000000000001801
83.0
MMGS3_k127_1979932_69
Doubled CXXCH motif (Paired_CXXCH_1)
-
-
-
0.00000000000000002388
94.0
MMGS3_k127_1979932_7
repeat-containing protein
-
-
-
2.497e-202
651.0
MMGS3_k127_1979932_70
Domain of unknown function (DUF1902)
-
-
-
0.00000000000000005291
85.0
MMGS3_k127_1979932_71
Doubled CXXCH motif (Paired_CXXCH_1)
-
-
-
0.0000000000000003123
88.0
MMGS3_k127_1979932_72
-
-
-
-
0.000000000000003492
90.0
MMGS3_k127_1979932_73
-
-
-
-
0.0000000000002507
76.0
MMGS3_k127_1979932_74
-
-
-
-
0.000001011
57.0
MMGS3_k127_1979932_75
Two component, sigma54 specific, transcriptional regulator, Fis family
K02481,K07714
-
-
0.00000462
48.0
MMGS3_k127_1979932_8
Tetratricopeptide TPR_2 repeat protein
-
-
-
6.69e-198
643.0
MMGS3_k127_1979932_9
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
Could be involved in insertion of integral membrane proteins into the membrane
K08998
-
-
0.00000000000000000001218
99.0
MMGS3_k127_1992842_2
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.000000000008635
67.0
MMGS3_k127_1992842_3
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K05589
-
-
0.00000000000000000000000005523
111.0
MMGS3_k127_2160841_0
TIGRFAM ATP-dependent helicase HrpA
K03578
-
3.6.4.13
0.0
1549.0
MMGS3_k127_2160841_1
Bifunctional purine biosynthesis protein PurH
K00602
-
2.1.2.3,3.5.4.10
2.984e-260
815.0
MMGS3_k127_2160841_10
Domain in cystathionine beta-synthase and other proteins.
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K09888
-
-
0.0000000000000000000000000000000002898
138.0
MMGS3_k127_2344661_6
-
-
-
-
0.0000000000008283
71.0
MMGS3_k127_2360122_0
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
K01007
-
2.7.9.2
0.0
1282.0
MMGS3_k127_2360122_1
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
2.52e-297
928.0
MMGS3_k127_2383027_1
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
K04656
-
-
4.525e-297
938.0
MMGS3_k127_2511645_1
Belongs to the enoyl-CoA hydratase isomerase family
K19640
-
-
1.18e-212
690.0
MMGS3_k127_2511645_10
Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
1.457e-319
983.0
MMGS3_k127_2527394_10
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
3.008e-218
685.0
MMGS3_k127_2527394_11
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
2.166e-216
679.0
MMGS3_k127_2527394_12
AAA ATPase, central domain protein
K07478
-
-
2.289e-214
676.0
MMGS3_k127_2527394_13
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
1.186e-203
640.0
MMGS3_k127_2527394_14
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K03670
-
-
1.958e-240
752.0
MMGS3_k127_2527394_70
Cytochrome c
K00413
-
-
0.0000000000000000000000000000000001265
138.0
MMGS3_k127_2527394_71
protein conserved in bacteria
-
-
-
0.0000000000000000000000000000000002236
145.0
MMGS3_k127_2527394_72
Type II secretory pathway, component
-
-
-
0.0000000000000000000000000000000008702
149.0
MMGS3_k127_2527394_73
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.000000000000000000000000000000003685
130.0
MMGS3_k127_2527394_75
Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
9.122e-229
715.0
MMGS3_k127_2527394_80
Pentapeptide repeats (9 copies)
-
-
-
0.00000000000000000000006049
107.0
MMGS3_k127_2527394_81
Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
1.926e-226
714.0
MMGS3_k127_2527394_91
COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor)
ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
K12541
-
-
0.000000000000000000001757
96.0
MMGS3_k127_2585467_0
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1333.0
MMGS3_k127_2585467_1
Domain related to MnhB subunit of Na+/H+ antiporter
K05559
-
-
0.0
1167.0
MMGS3_k127_2585467_10
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.0000000000000000000000000000009437
125.0
MMGS3_k127_2585467_57
Belongs to the UPF0102 family
K07460
-
-
0.0000000000000000000000000002375
125.0
MMGS3_k127_2585467_58
Domain of unknown function (DUF4124)
-
-
-
0.000000000000000000000000002761
122.0
MMGS3_k127_2585467_59
PFAM Propeptide PepSY amd peptidase M4
-
-
-
0.00000000000000000000000001154
112.0
MMGS3_k127_2585467_6
Vacuole effluxer Atg22 like
-
-
-
2.538e-198
627.0
MMGS3_k127_2585467_60
-
-
-
-
0.00000000000000000000000008645
113.0
MMGS3_k127_2585467_61
Multiple resistance and pH regulation protein F (MrpF / PhaF)
K05563
-
-
0.0000000000000000000000001202
117.0
MMGS3_k127_2585467_62
cytochrome
-
-
-
0.0000000000000000000000002932
123.0
MMGS3_k127_2585467_63
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.000000000000000000000007736
103.0
MMGS3_k127_2585467_64
Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.294e-195
625.0
MMGS3_k127_2585467_9
Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1296.0
MMGS3_k127_2867921_10
radical SAM protein
-
-
-
5.094e-225
702.0
MMGS3_k127_2867921_11
modulator of DNA gyrase
K03568
-
-
3.471e-223
700.0
MMGS3_k127_2867921_12
Belongs to the aspartokinase family
K00928
-
2.7.2.4
3.565e-215
674.0
MMGS3_k127_2867921_13
ribonuclease, Rne Rng family
K08301
-
-
8.61e-210
666.0
MMGS3_k127_2867921_14
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
7.837e-203
638.0
MMGS3_k127_2867921_15
cytochrome d1 heme
K19345
-
-
3.098e-195
615.0
MMGS3_k127_2867921_16
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K03563
-
-
0.0000000000000000000000000008756
113.0
MMGS3_k127_2867921_5
Nitrite reductase
K15864
GO:0005575,GO:0005623,GO:0042597,GO:0044464
1.7.2.1,1.7.99.1
5.85e-282
875.0
MMGS3_k127_2867921_50
Modulates RecA activity
K03565
-
-
0.000000000000000000000000002248
116.0
MMGS3_k127_2867921_51
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.0000000000000000000252
90.0
MMGS3_k127_2867921_52
PFAM Type IV pilus assembly PilZ
-
-
-
0.000000000000000008304
86.0
MMGS3_k127_2867921_53
flagellar protein FlaG
K06603
-
-
0.0000000000000003492
83.0
MMGS3_k127_2867921_57
COG1961 Site-specific recombinases, DNA invertase Pin homologs
-
-
-
0.000002056
53.0
MMGS3_k127_2867921_6
cytochrome
-
-
-
2.127e-270
840.0
MMGS3_k127_2867921_7
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
1.16e-265
839.0
MMGS3_k127_2867921_8
PFAM binding-protein-dependent transport systems inner membrane component
K02038
-
-
4.844e-259
814.0
MMGS3_k127_2867921_9
Protein of unknown function
-
-
-
1.847e-245
802.0
MMGS3_k127_2974830_0
EcoEI R protein C-terminal
K01153
-
3.1.21.3
0.0
1366.0
MMGS3_k127_2974830_1
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
2.761e-310
973.0
MMGS3_k127_2974830_20
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
K04764
-
-
0.000000000000000000000000000000000000007477
147.0
MMGS3_k127_2974830_3
thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence
K02945
-
-
2.216e-297
920.0
MMGS3_k127_2974830_30
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
K05788
-
-
0.00000000000000000000000000000000000001955
146.0
MMGS3_k127_2974830_31
BRO family, N-terminal domain
-
-
-
0.000000000000000000000000000000000005705
141.0
MMGS3_k127_2974830_32
Sporulation related domain
K03749
-
-
0.00000000000000000000000000000002213
133.0
MMGS3_k127_2974830_33
-
-
-
-
0.00000000000000000000000000002542
119.0
MMGS3_k127_2974830_34
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.000000000000000000002207
96.0
MMGS3_k127_2974830_35
HicA toxin of bacterial toxin-antitoxin,
-
-
-
0.00000000000000000001587
92.0
MMGS3_k127_2974830_36
Lipopolysaccharide assembly protein A domain
K08992
-
-
0.000000006662
64.0
MMGS3_k127_2974830_37
-
-
-
-
0.0004584
47.0
MMGS3_k127_2974830_4
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K00764
-
2.4.2.14
3.269e-263
816.0
MMGS3_k127_2974830_5
aminotransferase class I and II
K14261
-
-
5.546e-235
730.0
MMGS3_k127_2974830_6
homoserine dehydrogenase
K00003
-
1.1.1.3
6.488e-222
695.0
MMGS3_k127_2974830_7
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00836
-
2.6.1.76
1.017e-211
664.0
MMGS3_k127_2974830_8
Putative diguanylate phosphodiesterase
-
-
-
9.959e-210
689.0
MMGS3_k127_2974830_9
threonine synthase
K01733
-
4.2.3.1
3.628e-198
621.0
MMGS3_k127_3056085_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1254.0
MMGS3_k127_3173210_1
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1094.0
MMGS3_k127_337358_1
Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K02400
-
-
0.0
1088.0
MMGS3_k127_337358_10
sigma54 specific, transcriptional regulator, Fis family
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
transferase activity, transferring glycosyl groups
-
-
-
0.00000000000000000000001446
105.0
MMGS3_k127_337358_66
PFAM flagellar biosynthesis protein, FliO
K02418
-
-
0.000000000000000000003323
100.0
MMGS3_k127_337358_67
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
0.0000000000000000003428
91.0
MMGS3_k127_337358_68
-
-
-
-
0.0000000000000000005886
98.0
MMGS3_k127_337358_69
Phage transcriptional regulator AlpA
-
-
-
0.00000000000002643
75.0
MMGS3_k127_337358_7
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
2.059e-224
702.0
MMGS3_k127_3546831_1
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1360.0
MMGS3_k127_3551452_1
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1100.0
MMGS3_k127_3551452_10
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
COG0526 Thiol-disulfide isomerase and thioredoxins
-
-
-
0.00000000000000000000000000000000000000000002356
177.0
MMGS3_k127_3551452_27
Nucleotidyl transferase AbiEii toxin, Type IV TA system
-
-
-
0.000000000000000000000000000000000000000003397
168.0
MMGS3_k127_3551452_28
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.0000000000000000000000000000000000000001723
161.0
MMGS3_k127_3551452_29
Biopolymer transport protein
K03559
-
-
0.000000000000000000000000000000000000003692
150.0
MMGS3_k127_3551452_3
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
-
-
1.89e-267
834.0
MMGS3_k127_3551452_30
Pterin 4 alpha carbinolamine dehydratase
K01724
-
4.2.1.96
0.000000000000000000000000006053
113.0
MMGS3_k127_3551452_31
Uncharacterized ACR, COG1399
K07040
-
-
0.00000000000000000000000002659
114.0
MMGS3_k127_3551452_32
Belongs to the bacterial ribosomal protein bL32 family
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18138
-
-
0.0
1448.0
MMGS3_k127_355562_10
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
4.73e-305
951.0
MMGS3_k127_355562_100
Phage derived protein Gp49-like (DUF891)
-
-
-
0.000000000000000000000007135
108.0
MMGS3_k127_355562_101
Sterol-binding domain protein
K03690
-
-
0.00000000000000000000001063
108.0
MMGS3_k127_355562_102
cheY-homologous receiver domain
-
-
-
0.000000000000000000002722
95.0
MMGS3_k127_355562_103
Cbb3-type cytochrome oxidase component FixQ
-
-
-
0.00000000000000001052
84.0
MMGS3_k127_355562_104
protein conserved in bacteria
K09806
-
-
0.00000000000003648
88.0
MMGS3_k127_355562_105
PFAM cytochrome oxidase maturation protein cbb3-type
-
-
-
0.000000000001365
70.0
MMGS3_k127_355562_106
Putative addiction module component
-
-
-
0.000000000068
68.0
MMGS3_k127_355562_107
BrnA antitoxin of type II toxin-antitoxin system
-
-
-
0.000000003032
63.0
MMGS3_k127_355562_108
Putative ATP-dependent DNA helicase recG C-terminal
-
-
-
0.0000001395
55.0
MMGS3_k127_355562_109
Heme exporter protein D (CcmD)
K02196
-
-
0.00001299
56.0
MMGS3_k127_355562_11
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis
COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
K00266
-
1.4.1.13,1.4.1.14
4.343e-257
813.0
MMGS3_k127_355562_14
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
5.297e-257
799.0
MMGS3_k127_355562_15
Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
5.877e-254
790.0
MMGS3_k127_355562_16
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
2.79e-248
777.0
MMGS3_k127_355562_17
Sodium hydrogen exchanger
K11105
-
-
1.425e-231
730.0
MMGS3_k127_355562_18
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
1.172e-229
722.0
MMGS3_k127_355562_19
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
K03656
-
3.6.4.12
2.729e-229
733.0
MMGS3_k127_355562_2
Dehydrogenase E1 component
K00164
-
1.2.4.2
0.0
1291.0
MMGS3_k127_355562_20
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
4.808e-208
658.0
MMGS3_k127_355562_23
PFAM AMP-dependent synthetase
K01897
-
6.2.1.3
1.185e-206
661.0
MMGS3_k127_355562_24
Fructose-bisphosphate aldolase class-II
K01624
-
4.1.2.13
3.72e-197
617.0
MMGS3_k127_355562_25
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1106.0
MMGS3_k127_355562_30
Belongs to the peptidase M20A family. ArgE subfamily
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02275
-
1.9.3.1
0.0000000000000000000000000000000000114
147.0
MMGS3_k127_355562_87
PFAM Cupin 2 conserved barrel domain protein
K11312
-
-
0.00000000000000000000000000000000001574
140.0
MMGS3_k127_355562_88
Belongs to the bacterial histone-like protein family
-
-
-
0.00000000000000000000000000000000001574
140.0
MMGS3_k127_355562_89
Ribonuclease toxin, BrnT, of type II toxin-antitoxin system
K09803
-
-
0.00000000000000000000000000000000006255
135.0
MMGS3_k127_355562_9
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
8e-323
1000.0
MMGS3_k127_355562_90
signal sequence binding
K07152
-
-
0.0000000000000000000000000000000001155
151.0
MMGS3_k127_355562_92
-
-
-
-
0.000000000000000000000000000000002933
149.0
MMGS3_k127_355562_93
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K02197
-
-
0.000000000000000000000000000000006109
133.0
MMGS3_k127_355562_94
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
4.836e-263
814.0
MMGS3_k127_373473_50
belongs to the Fur family
K09826
-
-
0.00000000000000000000000000000000000000000006128
166.0
MMGS3_k127_373473_51
Plasmid maintenance system killer
K07334
-
-
0.0000000000000000000000000000000000000000001498
161.0
MMGS3_k127_373473_52
YGGT family
K02221
-
-
0.0000000000000000000000000000000000000000003982
163.0
MMGS3_k127_373473_53
-
-
-
-
0.00000000000000000000000000000000000000004227
154.0
MMGS3_k127_373473_54
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.0000000000000000000000000000000000003212
141.0
MMGS3_k127_373473_55
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1110.0
MMGS3_k127_382086_1
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1016.0
MMGS3_k127_382086_2
Participates in both transcription termination and antitermination
K02600
-
-
4.902e-249
775.0
MMGS3_k127_382086_3
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
2.594e-195
615.0
MMGS3_k127_382086_4
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum
K03587
-
3.4.16.4
4.416e-235
745.0
MMGS3_k127_4054793_30
Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
7.506e-218
681.0
MMGS3_k127_4054793_40
ParE toxin of type II toxin-antitoxin system, parDE
-
-
-
0.000000000000000000000000000000000000005622
147.0
MMGS3_k127_4054793_41
RelE-like toxin of type II toxin-antitoxin system HigB
K07334
-
-
0.0000000000000000000000000000000000002425
142.0
MMGS3_k127_4054793_42
-
-
-
-
0.000000000000000000000000000000000005524
140.0
MMGS3_k127_4054793_43
PFAM Uncharacterised protein family UPF0150
-
-
-
0.00000000000000000000000000000003142
127.0
MMGS3_k127_4054793_44
DNA polymerase beta domain protein region
K07075
-
-
0.0000000000000000000000000000003361
124.0
MMGS3_k127_4054793_46
InterPro IPR007367
-
-
-
0.00000000000000000005346
95.0
MMGS3_k127_4054793_47
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K03586
-
-
0.000000000000000001517
97.0
MMGS3_k127_4054793_48
Helix-turn-helix XRE-family like proteins
-
-
-
0.000000000000003177
76.0
MMGS3_k127_4054793_49
-
-
-
-
0.00000000000002935
81.0
MMGS3_k127_4054793_5
Belongs to the MurCDEF family
K01924
-
6.3.2.8
3.54e-212
676.0
MMGS3_k127_4054793_50
-
-
-
-
0.00000000000007684
73.0
MMGS3_k127_4054793_51
PFAM Uncharacterised protein family UPF0150
-
-
-
0.000000000002235
73.0
MMGS3_k127_4054793_52
-
-
-
-
0.0000000001068
70.0
MMGS3_k127_4054793_53
PFAM Uncharacterised protein family UPF0150
-
-
-
0.0000001994
57.0
MMGS3_k127_4054793_54
-
-
-
-
0.000003718
57.0
MMGS3_k127_4054793_55
HicA toxin of bacterial toxin-antitoxin,
-
-
-
0.00004269
48.0
MMGS3_k127_4054793_56
PFAM Uncharacterised protein family UPF0150
-
-
-
0.0001147
45.0
MMGS3_k127_4054793_57
Putative addiction module component
-
-
-
0.0001615
51.0
MMGS3_k127_4054793_58
-
-
-
-
0.0003026
49.0
MMGS3_k127_4054793_6
Belongs to the peptidase M16 family
K07263
-
-
1.835e-196
621.0
MMGS3_k127_4054793_7
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1483.0
MMGS3_k127_4077149_1
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
5.644e-259
805.0
MMGS3_k127_4113045_20
Helix-turn-helix domain
-
-
-
0.00000000000000000000000000000001435
130.0
MMGS3_k127_4113045_21
ParE toxin of type II toxin-antitoxin system, parDE
K06218
-
-
0.00000000000000000000001094
102.0
MMGS3_k127_4113045_22
FES
K10773
-
4.2.99.18
0.00000000000000000000007857
108.0
MMGS3_k127_4113045_23
-
-
-
-
0.000000000000003281
76.0
MMGS3_k127_4113045_24
Chemotaxis signal transduction protein
K03408
-
-
0.0000000000002871
70.0
MMGS3_k127_4113045_25
periplasmic protein
-
-
-
0.000002344
59.0
MMGS3_k127_4113045_3
Belongs to the RtcB family
K14415,K18148
-
6.5.1.3
1.79e-213
672.0
MMGS3_k127_4113045_4
HipA N-terminal domain
K07154
-
2.7.11.1
4.794e-213
668.0
MMGS3_k127_4113045_5
Diguanylate cyclase phosphodiesterase with PAS PAC
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
8.968e-194
608.0
MMGS3_k127_4324222_6
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.0
1309.0
MMGS3_k127_4408099_1
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1237.0
MMGS3_k127_440872_1
DNA RNA helicase
-
-
-
0.0
1073.0
MMGS3_k127_440872_10
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
ParE toxin of type II toxin-antitoxin system, parDE
-
-
-
0.00000000000000000000000000000000000000002797
156.0
MMGS3_k127_440872_29
50S ribosomal protein L31
K02909
-
-
0.00000000000000000000000000000000007694
134.0
MMGS3_k127_440872_3
TIGRFAM ATP-dependent DNA helicase, RecQ
K03654
-
3.6.4.12
1.27e-283
905.0
MMGS3_k127_440872_30
SpoVT / AbrB like domain
K07172
-
-
0.0000000000000000000000000000000002082
133.0
MMGS3_k127_440872_31
PFAM Glycosyl transferase, group 1
-
-
-
0.00000000000000000000000000000002321
146.0
MMGS3_k127_440872_32
Could be involved in insertion of integral membrane proteins into the membrane
K08998
-
-
0.00000000000000000000000000000002797
126.0
MMGS3_k127_440872_33
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
K03536
-
3.1.26.5
0.00000000000000000000000000000004857
128.0
MMGS3_k127_440872_34
Belongs to the peptidase S26 family
K03100
-
3.4.21.89
0.0000000000000000000000000009294
125.0
MMGS3_k127_440872_35
PFAM Polysaccharide deacetylase
-
-
-
0.000000000000000000000003234
119.0
MMGS3_k127_440872_36
Shikimate kinase
-
-
-
0.0000000000000000000001982
105.0
MMGS3_k127_440872_37
-
-
-
-
0.000000000000000001387
100.0
MMGS3_k127_440872_38
Belongs to the bacterial ribosomal protein bL34 family
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
1.061e-244
771.0
MMGS3_k127_440872_42
Ribbon-helix-helix protein, copG family
-
-
-
0.000000001794
64.0
MMGS3_k127_440872_5
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
7.274e-240
754.0
MMGS3_k127_440872_6
PFAM malic
K00029
-
1.1.1.40
2.218e-222
695.0
MMGS3_k127_440872_7
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
9.687e-209
657.0
MMGS3_k127_440872_8
PFAM Amino acid
-
-
-
1.333e-207
653.0
MMGS3_k127_440872_9
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
5.468e-320
987.0
MMGS3_k127_534275_2
sulphate transporter
K03321
-
-
7.752e-229
722.0
MMGS3_k127_534275_3
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
2.633e-213
670.0
MMGS3_k127_585304_80
Controls the rotational direction of flagella during chemotaxis
K02415
-
-
0.000000000000000000000000005808
115.0
MMGS3_k127_585304_81
Na+/H+ ion antiporter subunit
K05569
-
-
0.0000000000000000000000002683
114.0
MMGS3_k127_585304_82
Invasion gene expression up-regulator, SirB
-
-
-
0.0000000000000000000000003803
117.0
MMGS3_k127_585304_83
Domain of unknown function (DUF4156)
-
-
-
0.0000000000000000000000003935
111.0
MMGS3_k127_585304_84
Belongs to the bacterial ribosomal protein bL33 family
K02913
-
-
0.000000000000000000000009365
100.0
MMGS3_k127_585304_85
PFAM Na H antiporter subunit
K05571
-
-
0.00000000000000000000006038
109.0
MMGS3_k127_585304_86
Multiple resistance and pH regulation protein F
K05570
-
-
0.000000000000000000004305
94.0
MMGS3_k127_585304_87
COG0526 Thiol-disulfide isomerase and thioredoxins
-
-
-
0.00000000000000000006566
92.0
MMGS3_k127_585304_9
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
7.651e-201
632.0
MMGS3_k127_637864_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PemK-like, MazF-like toxin of type II toxin-antitoxin system
K07171
-
-
0.000001438
50.0
MMGS3_k127_637864_3
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
6.47e-231
722.0
MMGS3_k127_659656_20
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
3.07e-272
841.0
MMGS3_k127_663433_12
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
1.236e-268
837.0
MMGS3_k127_663433_13
COG2223 Nitrate nitrite transporter
K02575
-
-
1.12e-264
820.0
MMGS3_k127_663433_14
signal transduction histidine kinase
-
-
-
2.27e-243
777.0
MMGS3_k127_663433_15
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
3.112e-232
728.0
MMGS3_k127_663433_16
O-acetylhomoserine
K01740
-
2.5.1.49
1.456e-226
709.0
MMGS3_k127_663433_17
PFAM TrkA-N domain
K03499
-
-
3.455e-219
689.0
MMGS3_k127_663433_18
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
6.343e-205
650.0
MMGS3_k127_663433_19
Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
K03498
-
-
3.264e-201
636.0
MMGS3_k127_663433_2
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.00000000000000000000000000000000763
130.0
MMGS3_k127_663433_97
Phosphotransferase System
K11189
-
-
0.0000000000000000000000000000002052
125.0
MMGS3_k127_663433_98
cold-shock protein
K03704
-
-
0.000000000000000000000000000007752
120.0
MMGS3_k127_663433_99
Universal stress protein
K06149
-
-
0.00000000000000000000000000009643
120.0
MMGS3_k127_710816_0
PEP-utilising enzyme, TIM barrel domain
K01007
-
2.7.9.2
0.0
1066.0
MMGS3_k127_721220_0
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
1752.0
MMGS3_k127_721220_1
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1463.0
MMGS3_k127_721220_10
Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
-
-
-
0.000000000000000000000000000000000000001148
157.0
MMGS3_k127_721220_117
PFAM Positive regulator of sigma(E) RseC MucC
K03803
-
-
0.000000000000000000000000000000000000001358
151.0
MMGS3_k127_721220_118
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.000000000000000000000000000000000001384
139.0
MMGS3_k127_721220_121
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00340
-
1.6.5.3
0.000000000000000000000000000000000001808
143.0
MMGS3_k127_721220_122
transcriptional regulator
K07726
-
-
0.000000000000000000000000000000000005507
141.0
MMGS3_k127_721220_123
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
PFAM NADH ubiquinone oxidoreductase complex I intermediate-associated protein 30
-
-
-
0.00000000000000000000000000000001039
138.0
MMGS3_k127_721220_125
CRS1_YhbY
K07574
-
-
0.0000000000000000000000000000001959
125.0
MMGS3_k127_721220_126
PFAM Anti sigma-E protein RseA
K03597
-
-
0.00000000000000000000000000000199
126.0
MMGS3_k127_721220_127
Bacterial protein of unknown function (DUF934)
-
-
-
0.000000000000000000000000000005415
128.0
MMGS3_k127_721220_128
PFAM Preprotein translocase SecG subunit
K03075
-
-
0.0000000000000000000000000000267
121.0
MMGS3_k127_721220_129
COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
-
-
-
0.00000000000000000000000000003088
128.0
MMGS3_k127_721220_13
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
2.131e-304
945.0
MMGS3_k127_721220_130
Cytotoxic translational repressor of toxin-antitoxin stability system
-
-
-
0.00000000000000000000000000007631
118.0
MMGS3_k127_721220_131
Protein of unknown function (DUF498/DUF598)
-
-
-
0.0000000000000000000000000001013
121.0
MMGS3_k127_721220_132
Helix-turn-helix XRE-family like proteins
K07726
-
-
0.00000000000000000000000000106
117.0
MMGS3_k127_721220_133
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
K00997
-
2.7.8.7
0.00000000000000000000000007832
123.0
MMGS3_k127_721220_134
PIN domain
-
-
-
0.0000000000000000000000005074
111.0
MMGS3_k127_721220_135
Domain of unknown function (DUF4845)
-
-
-
0.00000000000000000000002754
103.0
MMGS3_k127_721220_136
Involved in DNA repair and RecF pathway recombination
K03474,K03584
GO:0008150,GO:0009314,GO:0009628,GO:0050896
2.6.99.2
0.00000000000000000000004254
110.0
MMGS3_k127_721220_138
Flavinator of succinate dehydrogenase
K09159
-
-
0.0000000000000000000005336
100.0
MMGS3_k127_721220_14
Ribulose bisphosphate carboxylase large chain, catalytic domain
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
0.00000000000003624
83.0
MMGS3_k127_721220_146
-
-
-
-
0.0000000000001784
80.0
MMGS3_k127_721220_147
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00331,K03940
-
1.6.5.3,1.6.99.3
0.0000002088
55.0
MMGS3_k127_721220_157
Plasmid stability protein
K21495
-
-
0.00002552
51.0
MMGS3_k127_721220_158
-
K19168
-
-
0.00005494
51.0
MMGS3_k127_721220_159
FtsZ family, C-terminal domain
-
-
-
0.000124
51.0
MMGS3_k127_721220_16
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
6.157e-268
831.0
MMGS3_k127_721220_17
fad dependent oxidoreductase
K07137
-
-
1.846e-265
826.0
MMGS3_k127_721220_18
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
2.916e-261
819.0
MMGS3_k127_721220_19
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
8.731e-251
777.0
MMGS3_k127_721220_2
Bacterial DNA polymerase III, alpha subunit
K02337
-
2.7.7.7
0.0
1396.0
MMGS3_k127_721220_20
Belongs to the citrate synthase family
K01647
-
2.3.3.1
1.307e-248
771.0
MMGS3_k127_721220_21
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.888e-248
774.0
MMGS3_k127_721220_22
reductase 4Fe-4S
K00381
-
1.8.1.2
1.473e-232
732.0
MMGS3_k127_721220_23
TIGRFAM isocitrate dehydrogenase, NADP-dependent
K00031
-
1.1.1.42
6.846e-228
710.0
MMGS3_k127_721220_24
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K00335
-
1.6.5.3
8.234e-223
696.0
MMGS3_k127_721220_25
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
1.704e-219
692.0
MMGS3_k127_721220_26
domain protein
-
-
-
9.85e-217
702.0
MMGS3_k127_721220_27
Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit
K05568
-
-
6.868e-213
676.0
MMGS3_k127_721220_28
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
1.392e-210
664.0
MMGS3_k127_721220_29
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
3.511e-203
643.0
MMGS3_k127_721220_3
Required for chromosome condensation and partitioning
K03529
-
-
0.0
1371.0
MMGS3_k127_721220_30
Belongs to the CarA family
K01956
-
6.3.5.5
5.001e-198
623.0
MMGS3_k127_721220_31
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
1.5e-323
997.0
MMGS3_k127_721220_90
Belongs to the sigma-70 factor family. ECF subfamily
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
1362.0
MMGS3_k127_799611_1
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
5.9e-322
1000.0
MMGS3_k127_799611_10
PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
1.734e-243
766.0
MMGS3_k127_799611_30
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
5.421e-202
634.0
MMGS3_k127_799611_50
TIGRFAM preprotein translocase, YajC subunit
K03210
-
-
0.0000000000000000000000000000000002267
136.0
MMGS3_k127_799611_52
-
-
-
-
0.00000000000000000000000000000007551
128.0
MMGS3_k127_799611_53
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K04082
-
-
0.000000000000000000000000000001201
133.0
MMGS3_k127_799611_54
Frataxin-like domain
K06202
-
-
0.000000000000000000000004509
106.0
MMGS3_k127_799611_55
Protein of unknown function (DUF2892)
-
-
-
0.0000000000000000000000427
100.0
MMGS3_k127_799611_56
-
K17762
-
-
0.00000000000000000000269
98.0
MMGS3_k127_799611_57
Recombinase zinc beta ribbon domain
-
-
-
0.000006353
50.0
MMGS3_k127_799611_58
HTH-like domain
K07497
-
-
0.0007322
46.0
MMGS3_k127_799611_6
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
