Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COG1961 Site-specific recombinases, DNA invertase Pin homologs
-
-
-
0.0000000857
53.0
MMS1_k127_1688646_161
Biotin-lipoyl like
-
-
-
0.0000004356
61.0
MMS1_k127_1688646_162
membrane
K00389
-
-
0.000001651
55.0
MMS1_k127_1688646_163
Outer membrane efflux protein
K12340
-
-
0.000006541
59.0
MMS1_k127_1688646_164
-
-
-
-
0.000007049
49.0
MMS1_k127_1688646_166
Beta-ketoacyl synthase, N-terminal domain
-
-
-
0.0002502
51.0
MMS1_k127_1688646_17
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O
K05601
-
1.7.99.1
3.035e-237
738.0
MMS1_k127_1688646_18
PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I
K01835
-
5.4.2.2
6.93e-234
734.0
MMS1_k127_1688646_19
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K00700
-
2.4.1.18
1.686e-230
727.0
MMS1_k127_1688646_2
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1305.0
MMS1_k127_1688646_20
ATP synthase
K02412
-
3.6.3.14
1.269e-220
690.0
MMS1_k127_1688646_21
Belongs to the beta-ketoacyl-ACP synthases family
K09458
-
2.3.1.179
2.888e-217
679.0
MMS1_k127_1688646_22
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
7.925e-214
670.0
MMS1_k127_1688646_23
Flavin containing amine oxidoreductase
-
-
-
1.429e-205
647.0
MMS1_k127_1688646_24
Single-stranded-DNA-specific exonuclease (RecJ)
K07462
-
-
1.296e-200
637.0
MMS1_k127_1688646_25
TonB dependent receptor
K02014
-
-
1.924e-197
638.0
MMS1_k127_1688646_26
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.0
1050.0
MMS1_k127_1688646_50
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0
1029.0
MMS1_k127_1688646_60
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.0
1248.0
MMS1_k127_1899283_10
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
4.854e-258
800.0
MMS1_k127_1899283_11
Belongs to the anaerobic coproporphyrinogen-III oxidase family
Belongs to the succinate malate CoA ligase beta subunit family
K15231
-
2.3.3.8
4.263e-256
792.0
MMS1_k127_1899283_13
Peptidase M1 membrane alanine aminopeptidase
K01256,K08776
-
3.4.11.2
4.061e-247
797.0
MMS1_k127_1899283_14
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
1.123e-241
751.0
MMS1_k127_1899283_15
Hpt sensor hybrid histidine kinase
-
-
-
3.729e-237
762.0
MMS1_k127_1899283_16
Glycerol-3-phosphate dehydrogenase
K11473
-
-
1.098e-234
730.0
MMS1_k127_1899283_17
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
2.828e-222
692.0
MMS1_k127_1899283_18
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
2.745e-221
698.0
MMS1_k127_1899283_19
Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
K03498
-
-
9.749e-215
676.0
MMS1_k127_1899283_2
Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K00549
-
2.1.1.14
0.0
1141.0
MMS1_k127_1899283_20
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00833
-
2.6.1.62
1.335e-211
664.0
MMS1_k127_1899283_21
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
4.092e-208
655.0
MMS1_k127_1899283_22
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
K00997
-
2.7.8.7
0.00000000000000000000000000000000000000000003893
163.0
MMS1_k127_1899283_71
Controls the rotational direction of flagella during chemotaxis
K02415
-
-
0.00000000000000000000000000000000000000000005273
166.0
MMS1_k127_1899283_72
Heat shock protein DnaJ domain protein
K06203,K07126
-
-
0.0000000000000000000000000000000007499
132.0
MMS1_k127_1899283_73
Domain of unknown function (DUF4395)
-
-
-
0.000000000000000000000000000008646
123.0
MMS1_k127_1899283_74
Stress responsive A B Barrel Domain
-
-
-
0.00000000000000000000000000003833
118.0
MMS1_k127_1899283_75
metal-binding, possibly nucleic acid-binding protein
-
-
-
0.000000000000000000000000002246
115.0
MMS1_k127_1899283_76
S4 domain
K14761
-
-
0.00000000000000000000006714
99.0
MMS1_k127_1899283_77
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.0000000000000000000005236
95.0
MMS1_k127_1899283_78
-
-
-
-
0.0000000000000000000007789
98.0
MMS1_k127_1899283_79
-
-
-
-
0.000000000000000000002991
95.0
MMS1_k127_1899283_8
TIGRFAM filamentous haemagglutinin family outer membrane protein
-
-
-
2.306e-282
933.0
MMS1_k127_1899283_80
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K02008
-
-
0.0000000000000000000108
98.0
MMS1_k127_1899283_82
cobalt ion transport
K02009
-
-
0.00000000000000001797
85.0
MMS1_k127_1899283_83
-
-
-
-
0.0000000000000000205
84.0
MMS1_k127_1899283_84
-
-
-
-
0.0000000000000008905
78.0
MMS1_k127_1899283_86
-
-
-
-
0.00000000000005592
73.0
MMS1_k127_1899283_87
Alkyl hydroperoxide reductase
K03386
-
1.11.1.15
0.0000000001114
63.0
MMS1_k127_1899283_9
Highly conserved protein containing a thioredoxin domain
K06888
-
-
1.927e-261
820.0
MMS1_k127_1900631_0
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
1814.0
MMS1_k127_1900631_1
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
7.292e-252
796.0
MMS1_k127_1900631_140
Oxygen tolerance
-
-
-
0.0000000000000000000000000000000000003173
157.0
MMS1_k127_1900631_141
COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.000000000000000000000000000000000001122
146.0
MMS1_k127_1900631_142
Belongs to the Fur family
K03711
-
-
0.000000000000000000000000000000000006379
139.0
MMS1_k127_1900631_143
Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04078
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
0.000000000000000000000000000000000009825
138.0
MMS1_k127_1900631_144
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.00000000000000000000000000000000001743
136.0
MMS1_k127_1900631_145
Belongs to the Fur family
K09825
-
-
0.00000000000000000000000000000000007857
139.0
MMS1_k127_1900631_146
YtkA-like
-
-
-
0.000000000000000000000000000000001421
133.0
MMS1_k127_1900631_147
Phage integrase family
-
-
-
0.00000000000000000000000000000000223
147.0
MMS1_k127_1900631_148
Translation initiation factor SUI1
K03113
-
-
0.000000000000000000000000000000006669
130.0
MMS1_k127_1900631_149
addiction module killer protein
-
-
-
0.0000000000000000000000000000000306
129.0
MMS1_k127_1900631_15
Biotin carboxylase
K01959,K01961
-
6.3.4.14,6.4.1.1,6.4.1.2
4.207e-247
769.0
MMS1_k127_1900631_150
Highly conserved protein containing a thioredoxin domain
-
-
-
0.000000000000000000000000000003502
124.0
MMS1_k127_1900631_151
-
-
-
-
0.00000000000000000000000000006955
119.0
MMS1_k127_1900631_152
Polysaccharide deacetylase
-
-
-
0.0000000000000000000000000001626
134.0
MMS1_k127_1900631_153
RDD family
-
-
-
0.0000000000000000000000001577
111.0
MMS1_k127_1900631_154
dihydroneopterin aldolase
K01633
-
1.13.11.81,4.1.2.25,5.1.99.8
0.000000000000000000000001357
107.0
MMS1_k127_1900631_156
-
-
-
-
0.0000000000000000000000224
111.0
MMS1_k127_1900631_157
-
-
-
-
0.00000000000000000009498
94.0
MMS1_k127_1900631_158
-
-
-
-
0.00000000000000001369
85.0
MMS1_k127_1900631_159
membrane protein (DUF2078)
K08982
-
-
0.00000000000000006739
81.0
MMS1_k127_1900631_16
PFAM Alpha amylase, catalytic
K00690
-
2.4.1.7
7.76e-244
765.0
MMS1_k127_1900631_160
Required for maturation of 30S ribosomal subunits
K09748
-
-
0.0000000000000001468
85.0
MMS1_k127_1900631_161
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.0000000000000005868
87.0
MMS1_k127_1900631_162
nucleic-acid-binding protein implicated in transcription termination
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
1.858e-237
739.0
MMS1_k127_1900631_19
Belongs to the GARS family
K01945
-
6.3.4.13
4.752e-232
722.0
MMS1_k127_1900631_2
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
2.363e-224
701.0
MMS1_k127_1900631_23
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
3.02e-222
693.0
MMS1_k127_1900631_24
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
2.092e-216
676.0
MMS1_k127_1900631_25
Phospholipid glycerol acyltransferase
-
-
-
9.206e-215
681.0
MMS1_k127_1900631_26
TonB-dependent copper receptor
K02014
-
-
1.089e-204
655.0
MMS1_k127_1900631_27
COG0463 Glycosyltransferases involved in cell wall biogenesis
K13693
-
2.4.1.266
2.909e-203
639.0
MMS1_k127_1900631_28
EAL domain
-
-
-
3.658e-197
652.0
MMS1_k127_1900631_29
rod shape-determining protein mreB
K03569
-
-
1.222e-194
610.0
MMS1_k127_1900631_3
ATPase, P-type (transporting), HAD superfamily, subfamily IC
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
1.777e-284
882.0
MMS1_k127_1900631_90
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0
1319.0
MMS1_k127_1914417_100
Belongs to the peptidase M16 family
-
-
-
5.284e-210
660.0
MMS1_k127_1914417_101
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
1.076e-208
656.0
MMS1_k127_1914417_102
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
3.497e-208
653.0
MMS1_k127_1914417_103
The M ring may be actively involved in energy transduction
K02409
-
-
4.602e-208
661.0
MMS1_k127_1914417_104
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
1.036e-207
655.0
MMS1_k127_1914417_105
TonB-dependent receptor
K02014
-
-
2.23e-207
668.0
MMS1_k127_1914417_106
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
5.149e-207
651.0
MMS1_k127_1914417_107
COG1883 Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K01572
-
4.1.1.3
5.402e-207
651.0
MMS1_k127_1914417_108
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
1.162e-206
647.0
MMS1_k127_1914417_109
PFAM Radical SAM domain protein
K04069
-
1.97.1.4
9.654e-206
642.0
MMS1_k127_1914417_11
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1301.0
MMS1_k127_1914417_110
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
9.979e-205
644.0
MMS1_k127_1914417_111
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.189e-204
644.0
MMS1_k127_1914417_112
Aromatic acid exporter family member 1
-
-
-
4.621e-204
657.0
MMS1_k127_1914417_113
Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
K01710
-
4.2.1.46
3.468e-203
634.0
MMS1_k127_1914417_114
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
4.11e-203
635.0
MMS1_k127_1914417_115
domain protein
K09944
-
-
8.579e-202
637.0
MMS1_k127_1914417_116
Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily
K13747
-
4.1.1.96
2.585e-200
628.0
MMS1_k127_1914417_117
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00821
-
2.6.1.11,2.6.1.17
2.456e-199
626.0
MMS1_k127_1914417_118
Diguanylate cyclase
-
-
-
1.496e-198
661.0
MMS1_k127_1914417_119
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
3.123e-198
630.0
MMS1_k127_1914417_12
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.0
1264.0
MMS1_k127_1914417_120
Aminotransferase
K00812
-
2.6.1.1
3.486e-198
622.0
MMS1_k127_1914417_121
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
5.163e-198
625.0
MMS1_k127_1914417_122
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
5.443e-198
624.0
MMS1_k127_1914417_123
2-nitropropane dioxygenase
K00459
-
1.13.12.16
2.008e-197
619.0
MMS1_k127_1914417_124
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
9.732e-197
619.0
MMS1_k127_1914417_125
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1003.0
MMS1_k127_1914417_200
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
1.766e-315
974.0
MMS1_k127_1914417_260
Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
6.36e-291
905.0
MMS1_k127_1914417_380
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1487.0
MMS1_k127_1914417_40
PFAM biotin lipoyl attachment domain-containing protein
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
2.635e-251
784.0
MMS1_k127_1914417_570
proteins homologs of microcin C7 resistance protein MccF
-
-
-
0.00000000000000000000000000000000000000000003564
166.0
MMS1_k127_1914417_571
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
K03547,K05970
-
3.1.1.53
0.00000000000000000000000000000000000000000007956
174.0
MMS1_k127_1914417_572
thioesterase
K07107
-
-
0.000000000000000000000000000000000000000000238
161.0
MMS1_k127_1914417_573
Chaperone for flagella basal body P-ring formation
K02386
-
-
0.0000000000000000000000000000000000000000005548
168.0
MMS1_k127_1914417_574
protein-glutamate methylesterase
K03412
-
3.1.1.61,3.5.1.44
0.000000000000000000000000000000000000000002062
162.0
MMS1_k127_1914417_575
Chemoreceptor zinc-binding domain
-
-
-
0.000000000000000000000000000000000000000002228
161.0
MMS1_k127_1914417_576
-
-
-
-
0.000000000000000000000000000000000000000002581
160.0
MMS1_k127_1914417_577
Histidine kinase
K03407
-
2.7.13.3
0.000000000000000000000000000000000000000002854
158.0
MMS1_k127_1914417_578
Cell division protein FtsX
K09811
-
-
0.000000000000000000000000000000000000000003748
166.0
MMS1_k127_1914417_579
RDD family
-
-
-
0.000000000000000000000000000000000000000005825
160.0
MMS1_k127_1914417_58
Domain present in phytochromes and cGMP-specific phosphodiesterases.
-
-
-
1.534e-250
794.0
MMS1_k127_1914417_580
ATPase or kinase
K06925
-
-
0.00000000000000000000000000000000000000001071
158.0
MMS1_k127_1914417_581
transport system, permease component
K02069
-
-
0.00000000000000000000000000000000000000001103
163.0
MMS1_k127_1914417_582
Histidine kinase
-
-
-
0.00000000000000000000000000000000000000004393
157.0
MMS1_k127_1914417_583
Mut7-C RNAse domain
K09122
-
-
0.00000000000000000000000000000000000000006275
156.0
MMS1_k127_1914417_584
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.0000000000000000000000000000000000000005171
156.0
MMS1_k127_1914417_585
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K02956
-
-
0.000000000000000000000000000000000000001586
148.0
MMS1_k127_1914417_586
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.00000000000000000000000000000000000001425
146.0
MMS1_k127_1914417_587
-
-
-
-
0.00000000000000000000000000000000000002711
147.0
MMS1_k127_1914417_588
-
-
-
-
0.00000000000000000000000000000000000004474
148.0
MMS1_k127_1914417_589
Belongs to the ArsC family
-
-
-
0.00000000000000000000000000000000000005539
146.0
MMS1_k127_1914417_59
argininosuccinate lyase
K01755
-
4.3.2.1
2.079e-244
760.0
MMS1_k127_1914417_591
-
-
-
-
0.0000000000000000000000000000000000003665
147.0
MMS1_k127_1914417_592
-
-
-
-
0.0000000000000000000000000000000000009762
140.0
MMS1_k127_1914417_593
Multidrug Resistance protein
K03297
-
-
0.000000000000000000000000000000000001145
141.0
MMS1_k127_1914417_594
DnaK suppressor protein
K06204
-
-
0.000000000000000000000000000000000001257
141.0
MMS1_k127_1914417_595
DsrE/DsrF-like family
-
-
-
0.000000000000000000000000000000000006402
142.0
MMS1_k127_1914417_596
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K06891
-
-
0.00000000000000000000000000000000242
130.0
MMS1_k127_1914417_607
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
This enzyme acetylates the N-terminal alanine of ribosomal protein S18
K03789
-
2.3.1.128
0.000000000000000000000000000002026
125.0
MMS1_k127_1914417_613
S4 domain protein
-
-
-
0.000000000000000000000000000006072
121.0
MMS1_k127_1914417_614
Cytochrome c
-
-
-
0.00000000000000000000000000001312
120.0
MMS1_k127_1914417_615
undecaprenol kinase activity
K00901
-
2.7.1.107
0.0000000000000000000000000005756
117.0
MMS1_k127_1914417_616
Zinc finger cdgsh-type domain protein
-
-
-
0.0000000000000000000000000005952
113.0
MMS1_k127_1914417_617
phosphatidylserine decarboxylase
K01613
-
4.1.1.65
0.0000000000000000000000000007713
121.0
MMS1_k127_1914417_618
YGGT family
K02221
-
-
0.00000000000000000000000001513
111.0
MMS1_k127_1914417_62
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.00000000000000000000000001763
109.0
MMS1_k127_1914417_621
-
-
-
-
0.00000000000000000000000005673
114.0
MMS1_k127_1914417_622
Flagellar hook protein flgE
-
-
-
0.0000000000000000000000002177
108.0
MMS1_k127_1914417_623
Gluconate 2-dehydrogenase subunit 3
-
-
-
0.0000000000000000000000002713
112.0
MMS1_k127_1914417_624
endonuclease containing a URI domain
K07461
-
-
0.0000000000000000000000005476
106.0
MMS1_k127_1914417_625
-
-
-
-
0.000000000000000000000001316
106.0
MMS1_k127_1914417_626
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
K03536
-
3.1.26.5
0.000000000000000000000001514
106.0
MMS1_k127_1914417_628
Domain of unknown function (DUF2018)
-
-
-
0.00000000000000000000001111
103.0
MMS1_k127_1914417_629
-
-
-
-
0.00000000000000000000001159
101.0
MMS1_k127_1914417_63
TonB dependent receptor
K02014
-
-
1.364e-240
760.0
MMS1_k127_1914417_630
-
-
-
-
0.0000000000000000000000126
106.0
MMS1_k127_1914417_631
Anaphase-promoting complex, cyclosome, subunit 3
-
-
-
0.00000000000000000000001815
110.0
MMS1_k127_1914417_632
FlaG protein
K06603
-
-
0.00000000000000000000004701
103.0
MMS1_k127_1914417_635
TOBE domain
K02019
-
-
0.0000000000000000000001855
101.0
MMS1_k127_1914417_636
ribosomal RNA methyltransferase RrmJ FtsJ
K06442
-
2.1.1.226,2.1.1.227
0.0000000000000000000002143
106.0
MMS1_k127_1914417_638
NUDIX domain
-
-
-
0.000000000000000000001563
99.0
MMS1_k127_1914417_639
Preprotein translocase
K03210
-
-
0.000000000000000000002379
98.0
MMS1_k127_1914417_64
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
4.309e-240
744.0
MMS1_k127_1914417_640
AF0941-like
-
-
-
0.000000000000000000002525
96.0
MMS1_k127_1914417_641
DNA restriction-modification system
-
-
-
0.000000000000000000005211
95.0
MMS1_k127_1914417_642
-
-
-
-
0.00000000000000000008501
94.0
MMS1_k127_1914417_643
-
-
-
-
0.0000000000000000002549
94.0
MMS1_k127_1914417_644
Acetyltransferase (GNAT) domain
-
-
-
0.0000000000000000002554
91.0
MMS1_k127_1914417_645
-
-
-
-
0.0000000000000000004806
89.0
MMS1_k127_1914417_647
-
-
-
-
0.000000000000000001224
86.0
MMS1_k127_1914417_648
-
-
-
-
0.000000000000000001399
92.0
MMS1_k127_1914417_649
-
-
-
-
0.00000000000000001195
91.0
MMS1_k127_1914417_65
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
7.704e-240
746.0
MMS1_k127_1914417_650
Protein of unknown function (DUF2905)
-
-
-
0.00000000000000001672
83.0
MMS1_k127_1914417_651
-
-
-
-
0.0000000000000000241
83.0
MMS1_k127_1914417_652
energy transducer activity
K03832
-
-
0.00000000000000002677
92.0
MMS1_k127_1914417_653
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.00000000000000003181
81.0
MMS1_k127_1914417_654
COG2143 Thioredoxin-related protein
K04084
-
1.8.1.8
0.00000000000000008424
86.0
MMS1_k127_1914417_655
-
-
-
-
0.0000000000000002991
83.0
MMS1_k127_1914417_657
response regulator
-
-
-
0.000000000000001596
85.0
MMS1_k127_1914417_658
-
-
-
-
0.000000000000004975
76.0
MMS1_k127_1914417_659
-
-
-
-
0.000000000000009874
79.0
MMS1_k127_1914417_66
Flavin containing amine oxidoreductase
-
-
-
9.18e-236
740.0
MMS1_k127_1914417_660
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000117
75.0
MMS1_k127_1914417_661
oxygen carrier activity
-
-
-
0.00000000000001212
78.0
MMS1_k127_1914417_662
Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K02393
-
-
0.00000000000002537
82.0
MMS1_k127_1914417_664
regulation of methylation-dependent chromatin silencing
K07454
-
-
0.000000000000543
70.0
MMS1_k127_1914417_665
-
-
-
-
0.000000000003915
73.0
MMS1_k127_1914417_666
-
-
-
-
0.0000000000318
67.0
MMS1_k127_1914417_667
Oxaloacetate decarboxylase, gamma chain
K01573
-
4.1.1.3
0.000000000433
63.0
MMS1_k127_1914417_668
-
-
-
-
0.0000000009158
64.0
MMS1_k127_1914417_669
Two component transcriptional regulator, winged helix family
-
-
-
0.000000001106
61.0
MMS1_k127_1914417_67
COG0841 Cation multidrug efflux pump
-
-
-
1.069e-235
741.0
MMS1_k127_1914417_670
-
-
-
-
0.000000003351
58.0
MMS1_k127_1914417_671
-
-
-
-
0.00000002354
57.0
MMS1_k127_1914417_673
-
-
-
-
0.00000007062
60.0
MMS1_k127_1914417_675
-
-
-
-
0.0000001998
55.0
MMS1_k127_1914417_677
the gene is a member of the aaeXAB operon
K21695
-
-
0.0000004889
54.0
MMS1_k127_1914417_678
-
-
-
-
0.000001204
51.0
MMS1_k127_1914417_679
-
-
-
-
0.00000462
48.0
MMS1_k127_1914417_68
Saccharopine dehydrogenase
K00290
-
1.5.1.7
5.444e-235
729.0
MMS1_k127_1914417_680
-
-
-
-
0.00001817
49.0
MMS1_k127_1914417_681
Winged helix DNA-binding domain
-
-
-
0.00002668
51.0
MMS1_k127_1914417_683
FxsA cytoplasmic membrane protein
K07113
-
-
0.0000718
50.0
MMS1_k127_1914417_686
Transposase
K07497
-
-
0.0004827
43.0
MMS1_k127_1914417_687
-
-
-
-
0.0006373
44.0
MMS1_k127_1914417_688
Belongs to the small heat shock protein (HSP20) family
K13993
-
-
0.0008576
48.0
MMS1_k127_1914417_69
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
8.147e-235
736.0
MMS1_k127_1914417_690
-
-
-
-
0.0009065
44.0
MMS1_k127_1914417_691
-
-
-
-
0.0009869
44.0
MMS1_k127_1914417_7
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
1403.0
MMS1_k127_1914417_70
Oxidoreductase
K06151
-
1.1.99.3
1.389e-233
734.0
MMS1_k127_1914417_71
COG0659 Sulfate permease and related
K03321
-
-
1.323e-232
729.0
MMS1_k127_1914417_72
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
3.102e-232
721.0
MMS1_k127_1914417_73
Mur ligase middle domain
K01929
-
6.3.2.10
3.948e-228
715.0
MMS1_k127_1914417_74
anthranilate synthase component
K01657
-
4.1.3.27
3.986e-228
714.0
MMS1_k127_1914417_75
penicillin-binding protein
K05515
-
3.4.16.4
6.312e-228
720.0
MMS1_k127_1914417_76
molybdopterin oxidoreductase
-
-
-
2.136e-227
717.0
MMS1_k127_1914417_77
Belongs to the mannose-6-phosphate isomerase type 2 family
K00971
-
2.7.7.13
1.605e-226
708.0
MMS1_k127_1914417_78
Endoribonuclease that initiates mRNA decay
K18682
-
-
6.309e-225
707.0
MMS1_k127_1914417_79
CRISPR-associated protein (Cas_Csy1)
K19127
-
-
7.972e-225
701.0
MMS1_k127_1914417_8
Belongs to the ClpA ClpB family
K03694,K03695
-
-
0.0
1378.0
MMS1_k127_1914417_80
PFAM peptidase M3A and M3B thimet oligopeptidase F
K01414
-
3.4.24.70
8.98e-225
714.0
MMS1_k127_1914417_81
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
2.697e-224
702.0
MMS1_k127_1914417_82
Glutamate-1-semialdehyde aminotransferase
K01845
-
5.4.3.8
1.18e-222
695.0
MMS1_k127_1914417_83
PFAM EAL domain
-
-
-
8.81e-221
698.0
MMS1_k127_1914417_84
o-acetylhomoserine
K01740
-
2.5.1.49
3.406e-220
688.0
MMS1_k127_1914417_85
Belongs to the DEAD box helicase family
K05591
-
3.6.4.13
4.43e-220
690.0
MMS1_k127_1914417_86
Oxidoreductase
K00335
-
1.6.5.3
5.331e-218
689.0
MMS1_k127_1914417_87
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
2.527e-217
679.0
MMS1_k127_1914417_88
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
2.069e-216
675.0
MMS1_k127_1914417_89
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
4.376e-216
673.0
MMS1_k127_1914417_9
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1360.0
MMS1_k127_1914417_90
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00800
-
2.5.1.19
1.816e-215
675.0
MMS1_k127_1914417_91
Belongs to the MurCDEF family
K01924
-
6.3.2.8
2.488e-215
674.0
MMS1_k127_1914417_92
Belongs to the citrate synthase family
K01647
-
2.3.3.1
9.168e-215
672.0
MMS1_k127_1914417_93
Oxidoreductase
K00174
-
1.2.7.11,1.2.7.3
1.076e-214
670.0
MMS1_k127_1914417_94
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
2.054e-214
670.0
MMS1_k127_1914417_95
COG0457 FOG TPR repeat
-
-
-
1.77e-213
687.0
MMS1_k127_1914417_96
May be involved in recombinational repair of damaged DNA
K03631
-
-
7.237e-212
669.0
MMS1_k127_1914417_97
Belongs to the AAA ATPase family
-
-
-
2.479e-211
669.0
MMS1_k127_1914417_98
2-acylglycerophosphoethanolamine acyltransferase
K05939
-
2.3.1.40,6.2.1.20
4.287e-211
672.0
MMS1_k127_1914417_99
PFAM Methyl-accepting chemotaxis protein (MCP) signaling domain
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.0000000000000000000000000003383
114.0
MMS1_k127_1915627_145
Rhodanese-like domain
-
-
-
0.00000000000000000000000001255
112.0
MMS1_k127_1915627_146
-
-
-
-
0.00000000000000000000000007909
110.0
MMS1_k127_1915627_147
Rod binding protein
-
-
-
0.0000000000000000000000001988
108.0
MMS1_k127_1915627_148
energy transducer activity
K03646,K03832
-
-
0.000000000000000000000000522
114.0
MMS1_k127_1915627_149
-
-
-
-
0.000000000000000000000003345
106.0
MMS1_k127_1915627_15
Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K01711
-
4.2.1.47
2.313e-229
713.0
MMS1_k127_1915627_150
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.0000000000000000000006401
101.0
MMS1_k127_1915627_151
Alkyl hydroperoxide reductase
K03386
-
1.11.1.15
0.000000000000005762
74.0
MMS1_k127_1915627_152
flagellar biosynthesis
K02404
-
-
0.000000004378
57.0
MMS1_k127_1915627_153
response regulator receiver
-
-
-
0.00000008822
63.0
MMS1_k127_1915627_154
PFAM OmpA domain protein transmembrane region-containing protein
-
-
-
0.000001909
56.0
MMS1_k127_1915627_16
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
2.987e-225
704.0
MMS1_k127_1915627_17
CDP-glucose 4,6-dehydratase
K01709
-
4.2.1.45
1.112e-214
669.0
MMS1_k127_1915627_18
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
K03593
-
-
1.697e-208
653.0
MMS1_k127_1915627_19
diguanylate cyclase
-
-
-
1.571e-207
661.0
MMS1_k127_1915627_2
-
-
-
-
0.0
1154.0
MMS1_k127_1915627_20
Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K18285
-
2.5.1.120
3.177e-202
631.0
MMS1_k127_1915627_21
Belongs to the aspartokinase family
K00928
-
2.7.2.4
1.22e-201
633.0
MMS1_k127_1915627_22
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1074.0
MMS1_k127_1915627_50
Involved in the biosynthesis of porphyrin-containing compound
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
K00820
-
2.6.1.16
8.4e-309
954.0
MMS1_k127_1915627_60
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1071.0
MMS1_k127_2616333_190
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Belongs to the NiFe NiFeSe hydrogenase large subunit family
K05922
-
1.12.5.1
0.0
1022.0
MMS1_k127_2616333_200
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
K04656
-
-
1.09e-298
932.0
MMS1_k127_2616333_240
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1369.0
MMS1_k127_2616333_30
YcaO cyclodehydratase, ATP-ad Mg2+-binding
K09136
-
-
5.293e-271
841.0
MMS1_k127_2616333_300
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
K02387
-
-
0.000000000000000000000000000000000000002783
151.0
MMS1_k127_2616333_36
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.0000000000000000000000000000000000007274
141.0
MMS1_k127_2616333_37
Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains
K02584
-
-
7.748e-252
786.0
MMS1_k127_2616333_370
Protein of unknown function (DUF2393)
-
-
-
0.000000000000000000000000000000000001085
144.0
MMS1_k127_2616333_371
Binds directly to 16S ribosomal RNA
K02968
-
-
0.000000000000000000000000000000000005284
138.0
MMS1_k127_2616333_373
Uncharacterized ACR, COG1993
K09137
-
-
0.0000000000000000000000000000000000164
138.0
MMS1_k127_2616333_374
-
-
-
-
0.00000000000000000000000000000000002935
140.0
MMS1_k127_2616333_375
NifQ
K15790
-
-
0.00000000000000000000000000000000002959
138.0
MMS1_k127_2616333_376
ASCH
-
-
-
0.00000000000000000000000000000000003362
138.0
MMS1_k127_2616333_377
-
-
-
-
0.0000000000000000000000000000000001207
137.0
MMS1_k127_2616333_378
Pathogenicity locus
-
-
-
0.0000000000000000000000000000000001542
134.0
MMS1_k127_2616333_379
DNA-binding protein VF530
-
-
-
0.0000000000000000000000000000000005144
131.0
MMS1_k127_2616333_38
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
1.189e-246
764.0
MMS1_k127_2616333_380
Belongs to the P(II) protein family
K04751
-
-
0.000000000000000000000000000000001131
134.0
MMS1_k127_2616333_381
DsrE/DsrF-like family
-
-
-
0.000000000000000000000000000000001764
135.0
MMS1_k127_2616333_382
ABC-type transport system involved in resistance to organic solvents auxiliary component
K07323
-
-
0.000000000000000000000000000000001825
136.0
MMS1_k127_2616333_383
putative NADH-ubiquinone oxidoreductase chain E
K00334
-
1.6.5.3
0.000000000000000000000000000000003118
129.0
MMS1_k127_2616333_384
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K09747
-
-
0.00000000000000000000000000000000386
130.0
MMS1_k127_2616333_385
Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K00012
-
1.1.1.22
3.092e-244
758.0
MMS1_k127_2616333_400
Protein of unknown function (DUF465)
K09794
-
-
0.00000000000000000000000000008307
117.0
MMS1_k127_2616333_401
Flagellar hook-basal body complex protein FliE
K02408
-
-
0.0000000000000000000000000001798
117.0
MMS1_k127_2616333_402
-
-
-
-
0.0000000000000000000000000002409
120.0
MMS1_k127_2616333_403
-
-
-
-
0.0000000000000000000000000003532
124.0
MMS1_k127_2616333_404
Ferredoxin
-
-
-
0.0000000000000000000000000006088
115.0
MMS1_k127_2616333_405
Sulphur oxidation protein SoxZ
K17227
-
-
0.000000000000000000000000002701
113.0
MMS1_k127_2616333_406
Rhodanese Homology Domain
-
-
-
0.00000000000000000000000001139
113.0
MMS1_k127_2616333_407
Cytochrome c553
K08738
GO:0005575,GO:0005623,GO:0042597,GO:0044464
-
0.00000000000000000000000008787
109.0
MMS1_k127_2616333_408
Belongs to the bacterial ribosomal protein bL33 family
K02913
-
-
0.0000000000000000000000001527
105.0
MMS1_k127_2616333_409
Cytochrome oxidase maturation protein
-
-
-
0.000000000000000000000002375
103.0
MMS1_k127_2616333_41
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
GO:0003674,GO:0005488,GO:0005515,GO:0042802
3.6.4.12
7.013e-244
760.0
MMS1_k127_2616333_410
Prokaryotic N-terminal methylation motif
-
-
-
0.000000000000000000000004565
108.0
MMS1_k127_2616333_411
Protein of unknown function (DUF2393)
-
-
-
0.00000000000000000000000465
108.0
MMS1_k127_2616333_412
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
0.000000000000000000000007148
115.0
MMS1_k127_2616333_414
cytoplasmic domain of flagellar protein FhlB
K04061
-
-
0.00000000000000000000003372
100.0
MMS1_k127_2616333_416
alpha-ribazole phosphatase activity
-
-
-
0.0000000000000000000000689
107.0
MMS1_k127_2616333_417
-
-
-
-
0.000000000000000000003155
96.0
MMS1_k127_2616333_418
nitrogen fixation protein FixT
K02593
-
-
0.000000000000000000004359
94.0
MMS1_k127_2616333_419
general secretion pathway protein
-
-
-
0.00000000000000000000732
101.0
MMS1_k127_2616333_42
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K01703
-
4.2.1.33,4.2.1.35
1.296e-243
756.0
MMS1_k127_2616333_420
Domain of unknown function DUF302
-
-
-
0.000000000000000000008315
98.0
MMS1_k127_2616333_421
Xre family transcriptional regulator
-
-
-
0.00000000000000000006541
92.0
MMS1_k127_2616333_422
NifZ domain
K02597
-
-
0.0000000000000000000764
93.0
MMS1_k127_2616333_423
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family
K00569
-
2.1.1.67
0.0000000000000000002264
88.0
MMS1_k127_2616333_425
PFAM Ferric reductase domain protein transmembrane component domain
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.0000000000000005807
81.0
MMS1_k127_2616333_435
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.000000000000001704
76.0
MMS1_k127_2616333_438
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
1.145e-235
737.0
MMS1_k127_2616333_48
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
5.06e-234
732.0
MMS1_k127_2616333_49
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
exonuclease of the beta-lactamase fold involved in RNA processing
K07576
-
-
1.447e-230
721.0
MMS1_k127_2616333_51
Cysteine desulfurase
K04487
-
2.8.1.7
1.582e-230
718.0
MMS1_k127_2616333_52
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
1.961e-230
717.0
MMS1_k127_2616333_53
Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K03893
-
-
7.009e-220
688.0
MMS1_k127_2616333_6
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0
1263.0
MMS1_k127_2616333_60
ATP-dependent DNA helicase RecQ
K03654
-
3.6.4.12
5.58e-219
694.0
MMS1_k127_2616333_61
MMPL family
K07003
-
-
2.115e-218
702.0
MMS1_k127_2616333_62
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
5.747e-218
682.0
MMS1_k127_2616333_63
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
2.175e-216
679.0
MMS1_k127_2616333_64
Metallo-beta-lactamase superfamily
K22405
-
1.6.3.4
2.232e-213
668.0
MMS1_k127_2616333_65
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
2.796e-213
668.0
MMS1_k127_2616333_66
Cell division protein FtsI penicillin-binding protein
K03587
-
3.4.16.4
2.121e-210
669.0
MMS1_k127_2616333_67
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
1.088e-209
653.0
MMS1_k127_2616333_68
signal transduction protein containing a membrane domain an EAL and a GGDEF domain
-
-
-
3.357e-208
672.0
MMS1_k127_2616333_69
homoserine dehydrogenase
K00003
-
1.1.1.3
3.825e-208
653.0
MMS1_k127_2616333_7
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1256.0
MMS1_k127_2616333_70
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
3.995e-208
653.0
MMS1_k127_2616333_71
Cytochrome c oxidase accessory protein
-
-
-
5.995e-207
653.0
MMS1_k127_2616333_72
Belongs to the NifD NifK NifE NifN family
K02592
-
-
2.577e-205
646.0
MMS1_k127_2616333_73
signal transduction protein containing a membrane domain an EAL and a GGDEF domain
-
-
-
3.098e-205
659.0
MMS1_k127_2616333_74
sulfur dehydrogenase subunit
K17225
-
-
4.486e-205
647.0
MMS1_k127_2616333_75
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
K11784
-
1.21.98.1
4.493e-205
640.0
MMS1_k127_2616333_76
Potassium uptake protein
K03498
-
-
8.207e-204
642.0
MMS1_k127_2616333_77
COG1055 Na H antiporter NhaD and related arsenite permeases
-
-
-
2.999e-202
637.0
MMS1_k127_2616333_78
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
1.237e-198
625.0
MMS1_k127_2616333_79
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K03526
-
1.17.7.1,1.17.7.3
1.382e-195
615.0
MMS1_k127_2616333_8
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1241.0
MMS1_k127_2616333_90
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1157.0
MMS1_k127_404470_10
FGGY family of carbohydrate kinases, N-terminal domain
K11216
-
2.7.1.189
1.223e-264
823.0
MMS1_k127_404470_100
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Belongs to the short-chain dehydrogenases reductases (SDR) family
-
-
-
0.00000000000000000000000000000000000000000001275
171.0
MMS1_k127_404470_158
AMIN domain
-
-
-
0.0000000000000000000000000000000000000000001877
166.0
MMS1_k127_404470_159
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K11065
-
1.11.1.15
0.0000000000000000000000000000000000000000003739
163.0
MMS1_k127_404470_16
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
8.769e-230
719.0
MMS1_k127_404470_160
-
-
-
-
0.000000000000000000000000000000000000000006491
160.0
MMS1_k127_404470_161
PDP protein
-
-
-
0.00000000000000000000000000000000000000001857
158.0
MMS1_k127_404470_162
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.0000000000000000000000000000000000000001131
150.0
MMS1_k127_404470_163
metal cluster binding
-
-
-
0.0000000000000000000000000000000000000003289
154.0
MMS1_k127_404470_164
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.0000000000000000000000000000000000000005865
149.0
MMS1_k127_404470_165
Dinitrogenase iron-molybdenum cofactor biosynthesis protein
K02596
-
-
0.000000000000000000000000000000000000005848
148.0
MMS1_k127_404470_166
Flagellar biosynthetic protein FliQ
K02420
-
-
0.0000000000000000000000000000000000115
137.0
MMS1_k127_404470_167
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K02895
-
-
0.00000000000000000000000000000000002165
136.0
MMS1_k127_404470_168
Sigma 54 modulation protein / S30EA ribosomal protein
K05808
-
-
0.000000000000000000000000000000000044
136.0
MMS1_k127_404470_169
-
-
-
-
0.000000000000000000000000000000001146
132.0
MMS1_k127_404470_17
COG3893 inactivated superfamily I helicase
-
-
-
9.211e-229
732.0
MMS1_k127_404470_170
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K02954
-
-
0.000000000000000000000000000000001451
129.0
MMS1_k127_404470_172
Chorismate mutase
K04782
-
4.2.99.21
0.000000000000000000000000000000003953
130.0
MMS1_k127_404470_173
-
-
-
-
0.00000000000000000000000000000000455
132.0
MMS1_k127_404470_174
Cupin domain
K11312
-
-
0.00000000000000000000000000000001254
129.0
MMS1_k127_404470_175
-
-
-
-
0.0000000000000000000000000000002309
124.0
MMS1_k127_404470_176
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
-
-
-
0.0000000000000000000000000000006373
132.0
MMS1_k127_404470_177
Hydrolase
-
-
-
0.000000000000000000000000001263
126.0
MMS1_k127_404470_178
Flagellar FliJ protein
-
-
-
0.000000000000000000000000003684
115.0
MMS1_k127_404470_179
Uncharacterized conserved protein (DUF2196)
-
-
-
0.000000000000000000000000007291
110.0
MMS1_k127_404470_18
Abc transporter
K02035
-
-
1.382e-225
709.0
MMS1_k127_404470_180
methyl-accepting chemotaxis protein
K03406
-
-
0.000000000000000000000000179
106.0
MMS1_k127_404470_181
molybdopterin converting factor
K03636
-
-
0.0000000000000000000000005766
105.0
MMS1_k127_404470_182
molybdate ion transport
K02017,K06857
-
3.6.3.29,3.6.3.55
0.0000000000000000000000006002
109.0
MMS1_k127_404470_183
-
-
-
-
0.000000000000000000000001351
104.0
MMS1_k127_404470_184
signal transduction sensor histidine kinase
-
-
-
0.00000000000000000000003584
104.0
MMS1_k127_404470_185
FixH
-
-
-
0.0000000000000000000001012
104.0
MMS1_k127_404470_186
Glycosyl transferase family 2
-
-
-
0.0000000000000000000001971
111.0
MMS1_k127_404470_187
-
-
-
-
0.0000000000000000000003485
100.0
MMS1_k127_404470_189
-
-
-
-
0.000000000000000000009795
94.0
MMS1_k127_404470_19
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.028e-222
695.0
MMS1_k127_404470_201
Family of unknown function (DUF4006)
-
-
-
0.00000000003123
66.0
MMS1_k127_404470_203
-
-
-
-
0.00000006543
57.0
MMS1_k127_404470_204
-
-
-
-
0.0000005113
51.0
MMS1_k127_404470_205
Fe2 transport system protein A
K04758
-
-
0.000000653
53.0
MMS1_k127_404470_209
Acetyltransferase (GNAT) domain
-
-
-
0.00001833
55.0
MMS1_k127_404470_21
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
1.032e-222
696.0
MMS1_k127_404470_210
radicals which are normally produced within the cells and which are toxic to biological systems
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
1.889e-220
695.0
MMS1_k127_404470_23
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
9.749e-217
677.0
MMS1_k127_404470_24
TonB dependent receptor
K02014
-
-
6.248e-215
685.0
MMS1_k127_404470_25
Cysteine desulfurase
K04487
-
2.8.1.7
2.852e-211
661.0
MMS1_k127_404470_26
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
1.254e-209
657.0
MMS1_k127_404470_27
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
