Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
1.33e-309
951.0
PJD3_k127_10681_11
COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
K00059
-
1.1.1.100
6.581e-299
918.0
PJD3_k127_10681_12
Belongs to the DEAD box helicase family
K05591
-
3.6.4.13
1.818e-292
899.0
PJD3_k127_10681_13
gluconolactonase activity
-
-
-
3.55e-280
934.0
PJD3_k127_10681_14
Belongs to the thiolase family
K00626
-
2.3.1.9
2.908e-275
848.0
PJD3_k127_10681_15
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
1.607e-272
841.0
PJD3_k127_10681_16
Acetyl-coenzyme A transporter 1
-
-
-
1.442e-242
752.0
PJD3_k127_10681_17
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
K00557
-
2.1.1.35
1.297e-241
749.0
PJD3_k127_10681_18
Specifically methylates the adenine in position 1618 of 23S rRNA
K06970
-
2.1.1.181
1.218e-237
738.0
PJD3_k127_10681_19
COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain
-
-
-
4.518e-228
709.0
PJD3_k127_10681_2
ATP-dependent helicase HrpB
K03579
-
3.6.4.13
0.0
1600.0
PJD3_k127_10681_20
TRAP-type C4-dicarboxylate transport system periplasmic component
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
K00955,K00956
-
2.7.1.25,2.7.7.4
0.0
1058.0
PJD3_k127_10681_8
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
K01141
-
3.1.11.1
1.725e-318
975.0
PJD3_k127_10681_9
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
6.573e-313
960.0
PJD3_k127_11178_0
Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes
K00138
-
-
0.0
1031.0
PJD3_k127_11178_1
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
2.866e-242
749.0
PJD3_k127_11178_3
catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
K01624
-
4.1.2.13
4.805e-233
721.0
PJD3_k127_11178_4
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
K07746
-
-
0.00000000000000000002653
91.0
PJD3_k127_127804_2
COG3666 Transposase and inactivated derivatives
-
-
-
0.000000000000008505
77.0
PJD3_k127_127804_3
Belongs to the RelE toxin family
K19092
-
-
0.00000000001712
65.0
PJD3_k127_127804_4
Plasmid stabilization system
K19092
-
-
0.000002343
51.0
PJD3_k127_1329069_0
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
K03578
-
3.6.4.13
0.0
2481.0
PJD3_k127_1329069_1
Belongs to the peptidase M16 family
K06972
-
-
0.0
1937.0
PJD3_k127_1329069_10
Von Willebrand factor
-
-
-
0.0
1245.0
PJD3_k127_1329069_100
May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.000000000000000000000000000000000000007533
145.0
PJD3_k127_1329069_2
Tetratricopeptide repeat
-
-
-
0.0
1823.0
PJD3_k127_1329069_20
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K00764
-
2.4.2.14
0.0
1009.0
PJD3_k127_1329069_200
Nitrogen fixation protein NifW
K02595
-
-
0.00000000000000000000000000000000000003082
145.0
PJD3_k127_1329069_201
Belongs to the glutaredoxin family. Monothiol subfamily
K07390
-
-
0.0000000000000000000000000000000000004406
142.0
PJD3_k127_1329069_202
Ferredoxin
-
-
-
0.0000000000000000000000000000000000005553
142.0
PJD3_k127_1329069_203
4Fe-4S binding domain
-
-
-
0.000000000000000000000000000000000001838
139.0
PJD3_k127_1329069_204
Haemolysin-type calcium-binding repeat
-
-
-
0.000000000000000000000000000000002532
149.0
PJD3_k127_1329069_205
-
-
-
-
0.000000000000000000000000000000006819
127.0
PJD3_k127_1329069_206
Protein of unknown function (DUF1289)
-
-
-
0.00000000000000000000000000000002594
126.0
PJD3_k127_1329069_208
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000000000009524
124.0
PJD3_k127_1329069_209
NAD(P)H-binding
-
-
-
0.0000000000000000000000000000001381
132.0
PJD3_k127_1329069_21
Domain of unknown function (DUF3364)
K02591
-
1.18.6.1
4.676e-315
969.0
PJD3_k127_1329069_210
Metal-sensitive transcriptional repressor
-
-
-
0.000000000000000000000000000000278
128.0
PJD3_k127_1329069_211
Transposase
K07483
-
-
0.000000000000000000000000000003619
119.0
PJD3_k127_1329069_212
Transposase DDE domain
-
-
-
0.000000000000000000000000000005635
118.0
PJD3_k127_1329069_215
Nacht domain
-
-
-
0.000000000000000000000000001419
113.0
PJD3_k127_1329069_216
Nif11 domain
-
-
-
0.000000000000000000000000188
106.0
PJD3_k127_1329069_217
YcgL domain-containing protein
K09902
-
-
0.0000000000000000000000004289
107.0
PJD3_k127_1329069_218
P-type ATPase
K17686
-
3.6.3.54
0.00000000000000000000134
94.0
PJD3_k127_1329069_219
NifT/FixU protein
K02593
-
-
0.000000000000000000004727
94.0
PJD3_k127_1329069_22
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K03151
-
2.8.1.4
8.686e-315
967.0
PJD3_k127_1329069_220
-
-
-
-
0.00000000000000000005727
93.0
PJD3_k127_1329069_221
RnfH family Ubiquitin
K09801
-
-
0.000000000000000001737
89.0
PJD3_k127_1329069_222
Rop-like
-
-
-
0.000000000000000006624
85.0
PJD3_k127_1329069_223
Belongs to the BolA IbaG family
-
-
-
0.000000000000000009535
85.0
PJD3_k127_1329069_224
-
-
-
-
0.000000000000000009535
85.0
PJD3_k127_1329069_225
N-ATPase, AtpR subunit
-
-
-
0.00000000000000001751
87.0
PJD3_k127_1329069_226
-
-
-
-
0.0000000000000002976
81.0
PJD3_k127_1329069_227
-
-
-
-
0.0000000000000003163
84.0
PJD3_k127_1329069_228
Type VI secretion system (T6SS), amidase immunity protein
-
-
-
0.0000000000000007999
82.0
PJD3_k127_1329069_23
Nitrogenase component 1 type Oxidoreductase
K02586
-
1.18.6.1
1.878e-309
949.0
PJD3_k127_1329069_230
TPR repeat
-
-
-
0.00000000008893
73.0
PJD3_k127_1329069_231
NifZ domain
K02597
-
-
0.0000000002422
65.0
PJD3_k127_1329069_232
transposase activity
K07483
-
-
0.0000001962
52.0
PJD3_k127_1329069_234
-
-
-
-
0.000002505
57.0
PJD3_k127_1329069_236
Pyridoxamine 5'-phosphate oxidase
K07006,K22343,K22444
-
1.14.13.238,1.14.13.239
0.0009163
43.0
PJD3_k127_1329069_24
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K01703
-
4.2.1.33,4.2.1.35
4.612e-309
948.0
PJD3_k127_1329069_25
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K03732
-
3.6.4.13
1.569e-298
918.0
PJD3_k127_1329069_26
methyl-accepting chemotaxis protein
K03406
-
-
1.601e-296
915.0
PJD3_k127_1329069_27
Aldehyde dehydrogenase family
K00135
-
1.2.1.16,1.2.1.20,1.2.1.79
1.025e-291
898.0
PJD3_k127_1329069_28
Protein of unknown function (DUF1552)
-
-
-
2.722e-284
874.0
PJD3_k127_1329069_29
MATE efflux family protein
K03327
-
-
6.749e-277
854.0
PJD3_k127_1329069_3
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K20455
-
4.2.1.117
0.0
1716.0
PJD3_k127_1329069_30
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
5.185e-274
844.0
PJD3_k127_1329069_31
Belongs to the NifD NifK NifE NifN family
K02587
-
-
1.054e-272
844.0
PJD3_k127_1329069_32
Aminotransferase class-III
K00836
-
2.6.1.76
4.934e-272
839.0
PJD3_k127_1329069_33
MotA TolQ ExbB proton channel
K03561
-
-
4.337e-270
835.0
PJD3_k127_1329069_34
Dinitrogenase iron-molybdenum cofactor
K02585
-
-
4.383e-270
838.0
PJD3_k127_1329069_35
Belongs to the 'phage' integrase family
-
-
-
1.602e-265
819.0
PJD3_k127_1329069_36
protein conserved in bacteria
K09989
-
-
7.984e-263
809.0
PJD3_k127_1329069_37
COG0147 Anthranilate para-aminobenzoate synthases component I
K01665
-
2.6.1.85
4.84e-262
809.0
PJD3_k127_1329069_38
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
2.022e-258
797.0
PJD3_k127_1329069_39
peptidase M20
K01436
-
-
9.118e-258
794.0
PJD3_k127_1329069_4
Tfp pilus assembly protein
K08086
-
-
0.0
1672.0
PJD3_k127_1329069_40
Belongs to the folylpolyglutamate synthase family
K11754
-
6.3.2.12,6.3.2.17
1.581e-257
796.0
PJD3_k127_1329069_41
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
3.445e-257
794.0
PJD3_k127_1329069_42
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
2.739e-254
791.0
PJD3_k127_1329069_43
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K03684
-
3.1.13.5
6.846e-250
771.0
PJD3_k127_1329069_44
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
1.805e-249
778.0
PJD3_k127_1329069_45
protein conserved in bacteria
K09788
-
-
6.761e-247
763.0
PJD3_k127_1329069_46
COG0520 Selenocysteine lyase
-
-
-
1.804e-246
762.0
PJD3_k127_1329069_47
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
1.527e-245
758.0
PJD3_k127_1329069_48
Ankyrin repeat
-
-
-
1.509e-244
760.0
PJD3_k127_1329069_49
Belongs to the citrate synthase family
K01659
-
2.3.3.5
6.077e-244
755.0
PJD3_k127_1329069_5
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1590.0
PJD3_k127_1329069_50
Protein of unknown function (DUF2817)
-
-
-
7.466e-234
726.0
PJD3_k127_1329069_51
COG0006 Xaa-Pro aminopeptidase
K01271
-
3.4.13.9
2.182e-231
724.0
PJD3_k127_1329069_52
Aldo keto reductase
-
-
-
2.546e-225
699.0
PJD3_k127_1329069_53
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
4.012e-225
698.0
PJD3_k127_1329069_54
DNA polymerase III subunit delta
K02341
-
2.7.7.7
5.017e-222
689.0
PJD3_k127_1329069_55
transcriptional regulator
K02584
-
-
2.029e-221
698.0
PJD3_k127_1329069_56
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
1.692e-214
669.0
PJD3_k127_1329069_57
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
3.855e-214
670.0
PJD3_k127_1329069_58
Sh3 type 3 domain protein
-
-
-
1.862e-213
664.0
PJD3_k127_1329069_59
GGDEF domain
-
-
-
4.49e-211
661.0
PJD3_k127_1329069_6
Belongs to the peptidase S16 family
-
-
-
0.0
1575.0
PJD3_k127_1329069_60
Serine aminopeptidase, S33
-
-
-
1.076e-210
654.0
PJD3_k127_1329069_61
COG0457 FOG TPR repeat
-
-
-
1.515e-210
660.0
PJD3_k127_1329069_62
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
2.043e-209
652.0
PJD3_k127_1329069_63
in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon
K13634
-
-
1.942e-208
649.0
PJD3_k127_1329069_64
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1831.0
PJD3_k127_1333494_1
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
4.691e-308
947.0
PJD3_k127_1333494_11
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
1.234e-266
820.0
PJD3_k127_137911_5
Protein of unknown function (DUF3570)
-
-
-
2.689e-250
773.0
PJD3_k127_137911_6
TRAP-type C4-dicarboxylate transport system periplasmic component
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1817.0
PJD3_k127_1419988_1
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1704.0
PJD3_k127_1419988_10
COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K03563
-
-
0.00000000000000000000000000000009864
124.0
PJD3_k127_1419988_22
helix_turn_helix, arabinose operon control protein
-
-
-
0.000000000000000000003801
106.0
PJD3_k127_1419988_23
Acetyltransferase (GNAT) domain
-
-
-
0.0000000008313
66.0
PJD3_k127_1419988_24
-
-
-
-
0.000000001593
59.0
PJD3_k127_1419988_25
-
-
-
-
0.0001754
45.0
PJD3_k127_1419988_3
Belongs to the aspartokinase family
K00928
-
2.7.2.4
7.486e-259
800.0
PJD3_k127_1419988_4
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
0.0
1901.0
PJD3_k127_1499205_1
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1349.0
PJD3_k127_1499205_10
Sh3 type 3 domain protein
-
-
-
2.002e-226
706.0
PJD3_k127_1499205_11
Uncharacterized protein conserved in bacteria (DUF2236)
Catalyzes the ATP-dependent carboxylation of a covalently attached biotin and the transfer of the carboxyl group to pyruvate forming oxaloacetate
K01959
-
6.4.1.1
1.019e-316
971.0
PJD3_k127_1499205_8
Cytosol aminopeptidase family, catalytic domain
K01255
-
3.4.11.1
4.03e-303
929.0
PJD3_k127_1499205_9
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
1.647e-263
816.0
PJD3_k127_1512659_0
Protein conserved in bacteria
-
-
-
0.0
2064.0
PJD3_k127_1512659_1
Outer membrane protein beta-barrel family
-
-
-
0.0
1735.0
PJD3_k127_1512659_10
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COG3639 ABC-type phosphate phosphonate transport system, permease component
K02042
-
-
1.741e-307
945.0
PJD3_k127_1512659_24
AMP-binding enzyme C-terminal domain
K01897
-
6.2.1.3
1.157e-296
912.0
PJD3_k127_1512659_25
Polysaccharide biosynthesis protein
-
-
-
6.8e-291
904.0
PJD3_k127_1512659_26
Protein of unknown function (DUF3422)
-
-
-
1.401e-290
893.0
PJD3_k127_1512659_27
Sterol-sensing domain of SREBP cleavage-activation
K07003
-
-
1.518e-289
923.0
PJD3_k127_1512659_28
Outer membrane efflux protein
-
-
-
1.333e-284
878.0
PJD3_k127_1512659_29
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
2.553e-275
848.0
PJD3_k127_1512659_3
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.0
1563.0
PJD3_k127_1512659_30
Alkaline phosphatase
K01113
-
3.1.3.1
2.35e-274
846.0
PJD3_k127_1512659_31
MreB/Mbl protein
K04046
-
-
6.581e-274
845.0
PJD3_k127_1512659_32
polysaccharide biosynthetic process
-
-
-
1.181e-270
837.0
PJD3_k127_1512659_33
COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
K09015
-
-
7.558e-270
833.0
PJD3_k127_1512659_34
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
3.054e-265
817.0
PJD3_k127_1512659_35
Glycosyltransferase Family 4
-
-
-
3.354e-261
807.0
PJD3_k127_1512659_36
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
4.095e-260
803.0
PJD3_k127_1512659_37
Aminotransferase
K00812
-
2.6.1.1
2.609e-255
788.0
PJD3_k127_1512659_38
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K19804
-
-
1.373e-251
777.0
PJD3_k127_1512659_39
membrane
K07058
-
-
1.899e-241
749.0
PJD3_k127_1512659_4
Type III restriction enzyme, res subunit
-
-
-
0.0
1479.0
PJD3_k127_1512659_40
G-rich domain on putative tyrosine kinase
K05789
-
-
8.2e-239
739.0
PJD3_k127_1512659_41
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
1.894e-237
735.0
PJD3_k127_1512659_42
nucleoid-associated protein
K06899
-
-
1.033e-236
734.0
PJD3_k127_1512659_43
ATP-NAD kinase
-
-
-
1.421e-235
729.0
PJD3_k127_1512659_44
COG0477 Permeases of the major facilitator superfamily
K05820
-
-
2.954e-235
731.0
PJD3_k127_1512659_45
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
5.501e-235
728.0
PJD3_k127_1512659_46
GHMP kinases C terminal
K07031
-
2.7.1.168
1.727e-234
725.0
PJD3_k127_1512659_47
Prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
1.95e-233
724.0
PJD3_k127_1512659_48
Tetratricopeptide repeat
-
-
-
3.669e-233
726.0
PJD3_k127_1512659_49
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K00831
-
2.6.1.52
1.279e-232
721.0
PJD3_k127_1512659_5
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00210,K00800
-
1.3.1.12,2.5.1.19
0.0
1440.0
PJD3_k127_1512659_50
Belongs to the ompA family
K03286
-
-
1.168e-227
709.0
PJD3_k127_1512659_51
Phosphoribosylformylglycinamidine cyclo-ligase
K01933
-
6.3.3.1
1.267e-226
703.0
PJD3_k127_1512659_52
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K06917
-
-
2.734e-226
702.0
PJD3_k127_1512659_53
UDP-glucose 4-epimerase
K01784
-
5.1.3.2
6.265e-223
692.0
PJD3_k127_1512659_54
Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K01711
-
4.2.1.47
7.503e-222
690.0
PJD3_k127_1512659_56
Barrel-sandwich domain of CusB or HlyD membrane-fusion
-
-
-
2.504e-221
688.0
PJD3_k127_1512659_57
amino acid aldolase or racemase
-
-
-
3.282e-221
691.0
PJD3_k127_1512659_58
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
2.653e-220
684.0
PJD3_k127_1512659_59
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
4.738e-219
680.0
PJD3_k127_1512659_6
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1367.0
PJD3_k127_1512659_60
beta-galactosidase activity
-
-
-
6.432e-216
675.0
PJD3_k127_1512659_61
Tryptophanyl-tRNA synthetase
K01867
-
6.1.1.2
7.646e-216
671.0
PJD3_k127_1512659_62
Phospholipase
K01058
-
3.1.1.32,3.1.1.4
7.456e-215
668.0
PJD3_k127_1512659_63
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
1.537e-214
667.0
PJD3_k127_1512659_64
Beta-galactosidase
-
-
-
8.728e-210
657.0
PJD3_k127_1512659_65
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue
K07320
-
2.1.1.298
9.703e-207
643.0
PJD3_k127_1512659_66
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
2.181e-205
641.0
PJD3_k127_1512659_67
Histidine kinase
-
-
-
3.081e-204
641.0
PJD3_k127_1512659_68
esterase of the alpha-beta hydrolase superfamily
K07001
-
-
2.728e-201
627.0
PJD3_k127_1512659_69
Synthesizes selenophosphate from selenide and ATP
K01008
-
2.7.9.3
3.2e-199
625.0
PJD3_k127_1512659_7
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1927.0
PJD3_k127_2009973_10
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
1.204e-247
765.0
PJD3_k127_2009973_11
Predicted permease
K07089
-
-
1.446e-237
737.0
PJD3_k127_2009973_12
Outer membrane efflux protein
-
-
-
3.222e-234
732.0
PJD3_k127_2009973_13
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K01426
-
3.5.1.4
3.507e-317
973.0
PJD3_k127_2009973_6
Histidine kinase-like ATPases
-
-
-
7.642e-296
912.0
PJD3_k127_2009973_7
-
-
-
-
6.667e-265
816.0
PJD3_k127_2009973_8
-
-
-
-
1.952e-264
815.0
PJD3_k127_2009973_9
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
3.316e-253
782.0
PJD3_k127_2010930_1
Succinyl-CoA ligase like flavodoxin domain
K09181
-
-
0.0
1749.0
PJD3_k127_2010930_10
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
K01768
-
4.6.1.1
6.759e-297
912.0
PJD3_k127_2010930_11
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
1.921e-292
899.0
PJD3_k127_2010930_12
Type II secretory pathway, component ExeA
K02450
-
-
2.026e-280
866.0
PJD3_k127_2010930_13
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K02302,K02303
-
1.3.1.76,2.1.1.107,4.99.1.4
8.257e-280
862.0
PJD3_k127_2010930_14
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
1.926e-276
851.0
PJD3_k127_2010930_15
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
2.736e-267
825.0
PJD3_k127_2010930_16
Transcription factor
K18850
-
1.14.11.47
1.737e-264
814.0
PJD3_k127_2010930_17
Polysaccharide biosynthesis protein
K08679
-
5.1.3.6
1.248e-218
678.0
PJD3_k127_2010930_18
Arabinose-binding domain of AraC transcription regulator, N-term
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.00000000000000000000000000002126
129.0
PJD3_k127_2010930_44
chemotaxis
-
-
-
0.000000000002199
67.0
PJD3_k127_2010930_45
Type II secretion system protein B
-
-
-
0.00000000001181
74.0
PJD3_k127_2010930_46
-
-
-
-
0.00000000003861
64.0
PJD3_k127_2010930_5
Histidine Phosphotransfer domain
K07679
-
2.7.13.3
0.0
1249.0
PJD3_k127_2010930_6
Secretory lipase
-
-
-
0.0
1174.0
PJD3_k127_2010930_7
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
-
-
0.0
1075.0
PJD3_k127_2010930_8
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
0.0
1016.0
PJD3_k127_2010930_9
methyl-accepting chemotaxis protein
-
-
-
2.25e-304
938.0
PJD3_k127_2011506_0
3-hydroxyacyl-CoA dehydrogenase
K01782
-
1.1.1.35,4.2.1.17,5.1.2.3
0.0
1401.0
PJD3_k127_2011506_1
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
5.147e-279
861.0
PJD3_k127_2011506_5
carnitine dehydratase
-
-
-
4.403e-260
802.0
PJD3_k127_2011506_6
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
2.078e-256
791.0
PJD3_k127_2011506_7
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
1.101e-248
767.0
PJD3_k127_2011506_8
Glycosyl transferases group 1
-
-
-
3.743e-237
736.0
PJD3_k127_2011506_9
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
4.661e-235
728.0
PJD3_k127_2053654_0
belongs to the glycosyl hydrolase 13 family
-
-
-
0.0
1392.0
PJD3_k127_2053654_1
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
K03656
-
3.6.4.12
0.0
1350.0
PJD3_k127_2053654_10
Transglutaminase-like superfamily
-
-
-
5.086e-236
731.0
PJD3_k127_2053654_12
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.0
1245.0
PJD3_k127_260783_160
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1125.0
PJD3_k127_260783_27
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455,K11747
-
-
0.0
1117.0
PJD3_k127_260783_28
Diguanylate cyclase
-
-
-
0.0
1074.0
PJD3_k127_260783_29
COG4206 Outer membrane cobalamin receptor protein
K16092
-
-
0.0
1071.0
PJD3_k127_260783_3
Carbamoyl-phosphate synthetase ammonia chain
K01955
-
6.3.5.5
0.0
2137.0
PJD3_k127_260783_30
7TMR-DISM extracellular 2
-
-
-
0.0
1055.0
PJD3_k127_260783_31
May be involved in recombinational repair of damaged DNA
K03631
-
-
0.0
1052.0
PJD3_k127_260783_32
protein related to deoxyribodipyrimidine photolyase
K06876
-
-
0.0
1050.0
PJD3_k127_260783_33
Helicase SNF2 family domain protein
-
-
-
0.0
1041.0
PJD3_k127_260783_34
Na+/Pi-cotransporter
K03324
-
-
0.0
1036.0
PJD3_k127_260783_35
ABC transporter
-
-
-
0.0
1024.0
PJD3_k127_260783_36
Belongs to the glutamate synthase family
-
-
-
0.0
1005.0
PJD3_k127_260783_37
Subtilase family
K14645
-
-
1.059e-319
983.0
PJD3_k127_260783_38
7TMR-DISM extracellular 2
-
-
-
1.06e-318
984.0
PJD3_k127_260783_39
7TMR-DISM extracellular 2
-
-
-
1.146e-317
981.0
PJD3_k127_260783_4
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase
K14162
-
2.7.7.7
0.0
2021.0
PJD3_k127_260783_40
Belongs to the UPF0061 (SELO) family
-
-
-
4.659e-317
973.0
PJD3_k127_260783_41
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
-
-
-
1.191e-315
969.0
PJD3_k127_260783_42
Histidine kinase-like ATPases
-
-
-
1.894e-315
970.0
PJD3_k127_260783_43
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
1.068e-313
981.0
PJD3_k127_260783_44
belongs to the aldehyde dehydrogenase family
-
-
-
1.838e-312
958.0
PJD3_k127_260783_45
Participates in both transcription termination and antitermination
K02600
-
-
1.267e-310
953.0
PJD3_k127_260783_46
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K00758
-
2.4.2.4
2.179e-310
955.0
PJD3_k127_260783_47
With EutC catalyzes the formation of acetaldehyde and ammonia from ethanolamine
K03735
-
4.3.1.7
1.246e-307
943.0
PJD3_k127_260783_48
ATPase related to phosphate starvation-inducible protein PhoH
K07175
-
-
4.675e-305
935.0
PJD3_k127_260783_49
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
K03308
-
-
4.115e-304
935.0
PJD3_k127_260783_5
flagellar hook-associated protein
K02396
-
-
0.0
1906.0
PJD3_k127_260783_50
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
-
-
-
7.268e-304
933.0
PJD3_k127_260783_51
Belongs to the DNA photolyase family
K01669
-
4.1.99.3
1.02e-302
929.0
PJD3_k127_260783_52
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.01e-284
875.0
PJD3_k127_260783_57
protein conserved in bacteria
K09760
-
-
3.316e-279
863.0
PJD3_k127_260783_58
O-Antigen ligase
-
-
-
9.713e-279
858.0
PJD3_k127_260783_59
Amino acid permease
K16238
-
-
2.14e-277
856.0
PJD3_k127_260783_6
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1657.0
PJD3_k127_260783_60
NAD FAD-binding protein
K06954
-
-
3.525e-275
846.0
PJD3_k127_260783_61
COG2230 Cyclopropane fatty acid synthase and related methyltransferases
K00574
-
2.1.1.79
1.145e-274
845.0
PJD3_k127_260783_62
Acetyl-coenzyme A transporter 1
K08218
-
-
1.969e-274
847.0
PJD3_k127_260783_63
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K07516
-
1.1.1.35
4.108e-270
832.0
PJD3_k127_260783_64
Periplasmic binding protein domain
K01999,K11959
-
-
1.922e-261
809.0
PJD3_k127_260783_65
carbamoyl-phosphate synthetase glutamine chain
K01956
-
6.3.5.5
3.192e-252
778.0
PJD3_k127_260783_66
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
5.566e-251
775.0
PJD3_k127_260783_67
DNA recombination
-
-
-
1.616e-250
775.0
PJD3_k127_260783_68
Belongs to the bacterial flagellin family
K02397
-
-
5.743e-246
762.0
PJD3_k127_260783_69
Metallo-beta-lactamase superfamily
-
-
-
6.564e-245
757.0
PJD3_k127_260783_7
COG1960 Acyl-CoA dehydrogenases
K06445
-
-
0.0
1630.0
PJD3_k127_260783_70
Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit
K01572
-
4.1.1.3
1.405e-242
751.0
PJD3_k127_260783_71
differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
K00648,K16872
-
2.3.1.180,2.3.1.207
2.656e-240
743.0
PJD3_k127_260783_72
Fatty acid desaturase
-
-
-
4.41e-238
741.0
PJD3_k127_260783_73
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates
K01426
-
3.5.1.4
9.103e-236
728.0
PJD3_k127_260783_74
alcohol dehydrogenase
-
-
-
9.029e-232
719.0
PJD3_k127_260783_75
Taurine catabolism dioxygenase TauD, TfdA family
-
-
-
1.242e-230
715.0
PJD3_k127_260783_76
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
K15257
-
-
1.362e-223
693.0
PJD3_k127_260783_77
Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K02394
-
-
1.158e-222
693.0
PJD3_k127_260783_78
Belongs to the DNA photolyase family
K01669
-
4.1.99.3
1.625e-220
685.0
PJD3_k127_260783_79
Fatty acid desaturase
K10255
-
1.14.19.23,1.14.19.45
1.737e-220
689.0
PJD3_k127_260783_8
COG0823 Periplasmic component of the Tol biopolymer transport system
-
-
-
0.0
1612.0
PJD3_k127_260783_80
Fatty acid desaturase
-
-
-
2.013e-218
679.0
PJD3_k127_260783_82
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K02017
-
3.6.3.29
9.952e-213
663.0
PJD3_k127_260783_83
Protein of unknown function (DUF1722)
-
-
-
5.45e-211
658.0
PJD3_k127_260783_84
Fatty acid desaturase
K00507
-
1.14.19.1
1.225e-209
652.0
PJD3_k127_260783_85
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
1.679e-209
652.0
PJD3_k127_260783_86
Methylenetetrahydrofolate reductase
-
-
-
1.237e-205
640.0
PJD3_k127_260783_87
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
K05541
-
-
6.948e-205
639.0
PJD3_k127_260783_88
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
K00384
-
1.8.1.9
1.197e-202
631.0
PJD3_k127_260783_89
Arabinose-binding domain of AraC transcription regulator, N-term
Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K02407
-
-
0.0
2341.0
PJD3_k127_2681670_1
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K02406
-
-
0.0
2055.0
PJD3_k127_2681670_10
The M ring may be actively involved in energy transduction
K02409
-
-
0.0
1037.0
PJD3_k127_2681670_11
Belongs to the class-II aminoacyl-tRNA synthetase family
COG2148 Sugar transferases involved in lipopolysaccharide synthesis
K03606,K21303
-
2.7.8.40
7.118e-298
915.0
PJD3_k127_2681670_15
exonuclease of the beta-lactamase fold involved in RNA processing
K07576
-
-
4.749e-297
913.0
PJD3_k127_2681670_16
Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
K01840
-
5.4.2.8
3.884e-289
890.0
PJD3_k127_2681670_17
response regulator
K10943
-
-
5.196e-289
889.0
PJD3_k127_2681670_18
FOG PAS PAC domain
K03776
-
-
1.153e-286
885.0
PJD3_k127_2681670_19
SRP54-type protein, GTPase domain
K02404
-
-
3.059e-285
878.0
PJD3_k127_2681670_2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1532.0
PJD3_k127_2681670_20
Involved in type III protein export during flagellum assembly
K02412
-
3.6.3.14
2.061e-282
869.0
PJD3_k127_2681670_21
forms a homodimer and then a multimeric complex with NrdA
K00526
-
1.17.4.1
1.184e-249
771.0
PJD3_k127_2681670_22
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K00012
-
1.1.1.22
8.526e-247
763.0
PJD3_k127_2681670_23
His Kinase A (phosphoacceptor) domain
K10942
-
2.7.13.3
2.913e-240
745.0
PJD3_k127_2681670_24
Putative beta-barrel porin 2
K20920
-
-
1.053e-238
740.0
PJD3_k127_2681670_25
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K02401
-
-
1.681e-231
718.0
PJD3_k127_2681670_26
Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
K01710
-
4.2.1.46
3.057e-219
684.0
PJD3_k127_2681670_27
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02410
-
-
5.048e-204
636.0
PJD3_k127_2681670_28
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
6.02e-204
636.0
PJD3_k127_2681670_29
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
6.605e-204
636.0
PJD3_k127_2681670_3
Methyl-accepting chemotaxis
K03406
-
-
0.0
1392.0
PJD3_k127_2681670_30
FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K02416
-
-
1.744e-203
634.0
PJD3_k127_2681670_31
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
1.087e-201
631.0
PJD3_k127_2681670_32
transcriptional regulator
K03576
-
-
6.684e-200
623.0
PJD3_k127_2681670_33
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
Flagellar biosynthesis type III secretory pathway protein
K02411
-
-
0.0000000000000009501
89.0
PJD3_k127_2681670_8
Chemotaxis protein histidine kinase and related
K03407
-
2.7.13.3
0.0
1202.0
PJD3_k127_2681670_9
response regulator
K20977
-
-
0.0
1088.0
PJD3_k127_2684245_0
Ompa motb domain protein
-
-
-
0.0
2795.0
PJD3_k127_2684245_1
Cytochrome c peroxidase
K00428
-
1.11.1.5
0.0
2201.0
PJD3_k127_2684245_10
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COG1629 Outer membrane receptor proteins, mostly Fe transport
-
-
-
0.0
1235.0
PJD3_k127_2684245_130
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Type I restriction-modification system methyltransferase subunit
K03427
-
2.1.1.72
0.0
1017.0
PJD3_k127_2684245_25
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.0
994.0
PJD3_k127_2684245_26
Circularly permuted ATP-grasp type 2
-
-
-
3.153e-320
980.0
PJD3_k127_2684245_27
flavoprotein involved in K transport
-
-
-
1.342e-314
964.0
PJD3_k127_2684245_28
Long-chain fatty acid transport protein
K06076
-
-
2.595e-309
949.0
PJD3_k127_2684245_29
Threonine synthase
K01733
-
4.2.3.1
4.355e-307
943.0
PJD3_k127_2684245_3
efflux pump
K18138
-
-
0.0
1987.0
PJD3_k127_2684245_30
7 transmembrane helices usually fused to an inactive transglutaminase
-
-
-
1.153e-302
931.0
PJD3_k127_2684245_31
16S rRNA methyltransferase RsmB/F
K03500
-
2.1.1.176
1.584e-297
912.0
PJD3_k127_2684245_32
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
3.607e-297
916.0
PJD3_k127_2684245_33
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
5.646e-294
972.0
PJD3_k127_2684245_35
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Belongs to the Orn Lys Arg decarboxylase class-II family
K01581
-
4.1.1.17
3.043e-261
805.0
PJD3_k127_2684245_44
enoyl-CoA hydratase
-
-
-
1.184e-252
779.0
PJD3_k127_2684245_45
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
2.441e-252
778.0
PJD3_k127_2684245_46
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K17713
-
-
6.794e-246
761.0
PJD3_k127_2684245_47
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
-
-
-
6.224e-243
754.0
PJD3_k127_2684245_48
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K03526
-
1.17.7.1,1.17.7.3
3.339e-237
735.0
PJD3_k127_2684245_49
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
3.076e-236
733.0
PJD3_k127_2684245_5
Histidine kinase
K07678
-
2.7.13.3
0.0
1770.0
PJD3_k127_2684245_50
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
1.228e-227
705.0
PJD3_k127_2684245_51
Protein of unknown function (DUF2804)
-
-
-
2.377e-227
707.0
PJD3_k127_2684245_52
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
K08306
-
-
3.922e-222
690.0
PJD3_k127_2684245_53
Phosphate acyltransferases
-
-
-
5.974e-221
687.0
PJD3_k127_2684245_54
protein conserved in bacteria
-
-
-
3.398e-219
682.0
PJD3_k127_2684245_55
ABC-type branched-chain amino acid transport systems, periplasmic component
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1384.0
PJD3_k127_28660_100
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0
1344.0
PJD3_k127_28660_120
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.0000000000000000000000000000000000000000001419
159.0
PJD3_k127_28660_195
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.000000000000000000000000000000000000001309
148.0
PJD3_k127_28660_196
Polymer-forming cytoskeletal
-
-
-
0.000000000000000000000000000000000001846
143.0
PJD3_k127_28660_197
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.00000000000000000000000000000000002832
135.0
PJD3_k127_28660_198
rubredoxin
-
-
-
0.000000000000000000000000000000001938
128.0
PJD3_k127_28660_2
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1910.0
PJD3_k127_28660_20
gamma-glutamyltransferase
K00681
-
2.3.2.2,3.4.19.13
0.0
1109.0
PJD3_k127_28660_200
YnbE-like lipoprotein
-
-
-
0.0000000000000000000000000002838
117.0
PJD3_k127_28660_201
Putative zinc-finger
-
-
-
0.000000000000000000000000002547
111.0
PJD3_k127_28660_202
there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
K02913
-
-
0.00000000000000000000000007928
107.0
PJD3_k127_28660_205
KAP family P-loop domain
-
-
-
0.0000000000000000000003541
113.0
PJD3_k127_28660_207
glutamine amidotransferase
-
-
-
0.0000000000000000605
80.0
PJD3_k127_28660_208
glutamine amidotransferase
-
-
-
0.0000000001592
63.0
PJD3_k127_28660_209
O-Antigen ligase
K02847
-
-
0.000000000955
70.0
PJD3_k127_28660_21
COG0471 Di- and tricarboxylate transporters
-
-
-
0.0
1106.0
PJD3_k127_28660_210
Catalytic LigB subunit of aromatic ring-opening dioxygenase
-
-
-
0.00000003294
55.0
PJD3_k127_28660_211
-
-
-
-
0.00000004568
64.0
PJD3_k127_28660_213
glutamine amidotransferase
-
-
-
0.0002274
44.0
PJD3_k127_28660_22
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
0.0
1092.0
PJD3_k127_28660_23
COG0501 Zn-dependent protease with chaperone function
-
-
-
0.0
1084.0
PJD3_k127_28660_24
Chloride channel
-
-
-
0.0
1079.0
PJD3_k127_28660_25
cheY-homologous receiver domain
-
-
-
2.957e-319
981.0
PJD3_k127_28660_26
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
4.141e-314
964.0
PJD3_k127_28660_27
Trk system potassium uptake protein
K03498
-
-
4.397e-314
963.0
PJD3_k127_28660_28
belongs to the aldehyde dehydrogenase family
K00154
-
1.2.1.68
3.146e-312
957.0
PJD3_k127_28660_29
Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
1.064e-305
939.0
PJD3_k127_28660_3
Adenylate cyclase, class-I
K05851
-
4.6.1.1
0.0
1800.0
PJD3_k127_28660_30
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K01251
-
3.3.1.1
4.154e-305
936.0
PJD3_k127_28660_31
signal transduction protein
-
-
-
4.513e-303
930.0
PJD3_k127_28660_32
Belongs to the phosphatidylserine decarboxylase family
K01613
-
4.1.1.65
1.138e-301
928.0
PJD3_k127_28660_33
found to be peripherally associated with the inner membrane in Escherichia coli
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
2.066e-277
854.0
PJD3_k127_28660_38
Peptidase M23
-
-
-
2.971e-272
839.0
PJD3_k127_28660_39
TRAP-type mannitol chloroaromatic compound transport system, large permease component
-
-
-
3.119e-270
835.0
PJD3_k127_28660_4
phosphomannomutase
K15778
-
5.4.2.2,5.4.2.8
0.0
1586.0
PJD3_k127_28660_40
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K03500
-
2.1.1.176
3.332e-268
828.0
PJD3_k127_28660_41
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
4.632e-261
805.0
PJD3_k127_28660_46
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
1.361e-255
790.0
PJD3_k127_28660_47
protein (some members contain a von Willebrand factor type A (vWA) domain
K02034,K13891
-
-
1.567e-253
783.0
PJD3_k127_28660_48
Phosphate transport system permease
K02038
-
-
1.112e-252
782.0
PJD3_k127_28660_49
Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
-
-
-
5.13e-252
780.0
PJD3_k127_28660_5
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
0.0
1531.0
PJD3_k127_28660_50
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
1.388e-245
762.0
PJD3_k127_28660_51
fatty acid desaturase
-
-
-
1.257e-243
752.0
PJD3_k127_28660_52
Putative zinc-binding metallo-peptidase
-
-
-
9.92e-243
750.0
PJD3_k127_28660_53
Rossmann fold nucleotide-binding protein involved in DNA uptake
K04096
-
-
1.333e-242
752.0
PJD3_k127_28660_54
Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
K11076
-
-
1.51e-242
750.0
PJD3_k127_28660_55
Pyridine nucleotide-disulphide oxidoreductase
K05297
-
1.18.1.1
2.906e-237
735.0
PJD3_k127_28660_56
COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
K06597
-
-
3.896e-233
722.0
PJD3_k127_28660_57
Required for the activity of the bacterial periplasmic transport system of putrescine
K11069,K11073
-
-
9.821e-232
719.0
PJD3_k127_28660_58
Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
K03406
-
-
7.412e-226
706.0
PJD3_k127_28660_59
Capsule polysaccharide biosynthesis protein
K07265
-
-
7.804e-225
699.0
PJD3_k127_28660_6
Histidine kinase
-
-
-
0.0
1469.0
PJD3_k127_28660_60
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K00145
-
1.2.1.38
1.949e-222
690.0
PJD3_k127_28660_61
protein containing LysM domain
-
-
-
2.165e-222
690.0
PJD3_k127_28660_62
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Phosphate ABC transporter substrate-binding protein
K02040
-
-
1.415e-216
674.0
PJD3_k127_28660_64
LPP20 lipoprotein
-
-
-
3.353e-214
666.0
PJD3_k127_28660_65
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03110
-
-
4.795e-213
667.0
PJD3_k127_28660_66
Protein of unknown function (DUF3080)
-
-
-
1.134e-212
662.0
PJD3_k127_28660_67
Belongs to the ATCase OTCase family
K00609
-
2.1.3.2
1.203e-207
646.0
PJD3_k127_28660_68
Part of the ABC transporter FtsEX involved in cellular division
K09811
-
-
2.711e-207
647.0
PJD3_k127_28660_69
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K09001
-
2.7.1.170
2.021e-205
642.0
PJD3_k127_28660_7
ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
K02004
-
-
0.0
1404.0
PJD3_k127_28660_70
ArsR family transcriptional regulator
-
-
-
2.769e-205
641.0
PJD3_k127_28660_71
PFAM sulfatase
K03760,K19353
-
2.7.8.43
3.473e-205
651.0
PJD3_k127_28660_72
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K00826
-
2.6.1.42
7.707e-204
635.0
PJD3_k127_28660_73
ATPase, AAA
K03924
-
-
2.164e-199
623.0
PJD3_k127_28660_74
Belongs to the ompA family
K03286
-
-
3.674e-199
627.0
PJD3_k127_28660_75
Belongs to the prokaryotic GSH synthase family
K01920
-
6.3.2.3
9.247e-199
620.0
PJD3_k127_28660_76
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K00604
-
2.1.2.9
1.406e-194
608.0
PJD3_k127_28660_77
COG1352 Methylase of chemotaxis methyl-accepting proteins
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K00666,K20034
-
6.2.1.44
0.0
1142.0
PJD3_k127_2952927_30
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
0.0
1014.0
PJD3_k127_2952927_40
Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00836
-
2.6.1.76
1.223e-276
851.0
PJD3_k127_2952927_7
PHB de-polymerase C-terminus
K05973
-
3.1.1.75
1.128e-270
833.0
PJD3_k127_2952927_8
Domain of unknown function (DUF4915)
-
-
-
8.94e-269
826.0
PJD3_k127_2952927_9
Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine
K00641
-
2.3.1.31
4.386e-262
807.0
PJD3_k127_29742_0
Methionine synthase
K00548
-
2.1.1.13
0.0
2456.0
PJD3_k127_29742_1
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1530.0
PJD3_k127_29742_10
protease
K08303
-
-
1.029e-293
903.0
PJD3_k127_29742_11
Na -driven multidrug efflux pump
-
-
-
9.106e-281
865.0
PJD3_k127_29742_12
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
2.34e-276
851.0
PJD3_k127_29742_13
ABC-type oligopeptide transport system, periplasmic component
K13893
-
-
8.468e-273
846.0
PJD3_k127_29742_14
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
9.237e-246
758.0
PJD3_k127_29742_17
COG2133 Glucose sorbosone dehydrogenases
K21430
-
-
1.564e-242
749.0
PJD3_k127_29742_18
Sodium hydrogen antiporter
-
-
-
6.738e-227
706.0
PJD3_k127_29742_19
COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
K03466
-
-
1.661e-220
690.0
PJD3_k127_29742_2
Belongs to the ClpA ClpB family
K03694
-
-
0.0
1463.0
PJD3_k127_29742_20
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
K05539
-
-
4.944e-218
677.0
PJD3_k127_29742_21
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
K11391
-
2.1.1.174
5.929e-211
657.0
PJD3_k127_29742_22
Glycerol-3-phosphate dehydrogenase
K00057
-
1.1.1.94
3.579e-210
655.0
PJD3_k127_29742_23
peptidase
K04774
-
-
7.101e-209
652.0
PJD3_k127_29742_24
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.0000000000000000000000000000000000000002924
149.0
PJD3_k127_29742_69
protein conserved in bacteria
K05952
-
-
0.00000000000000000000000000000000000002808
143.0
PJD3_k127_29742_7
Histidine kinase
-
-
-
1e-323
995.0
PJD3_k127_29742_70
protein conserved in bacteria
-
-
-
0.00000000000000000000000000000000005429
139.0
PJD3_k127_29742_71
COG1943 Transposase and inactivated derivatives
-
-
-
0.00000000000000000000000000000322
120.0
PJD3_k127_29742_72
-
-
-
-
0.00000000000000000000000000004954
123.0
PJD3_k127_29742_73
Methyltransferase domain
-
-
-
0.000000000000000000000001653
113.0
PJD3_k127_29742_74
Protein of unknown function (DUF1348)
K09958
-
-
0.00000000000000000005532
89.0
PJD3_k127_29742_75
-
-
-
-
0.0000000000000000002669
90.0
PJD3_k127_29742_78
-
-
-
-
0.00000003474
55.0
PJD3_k127_29742_79
Integrase core domain
K07497
-
-
0.00001153
49.0
PJD3_k127_29742_8
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
K00322
-
1.6.1.1
1.717e-306
940.0
PJD3_k127_29742_9
Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Antitoxin component of a toxin-antitoxin (TA) module
-
-
-
0.0000000000000000000000000000000000005882
141.0
PJD3_k127_3372563_29
regulation of translation
K03812
-
-
0.0000000000000000000000000000000000006892
139.0
PJD3_k127_3372563_3
calcium- and calmodulin-responsive adenylate cyclase activity
-
-
-
0.0
1938.0
PJD3_k127_3372563_30
DNA-binding transcription factor activity
K03892
-
-
0.00000000000000000003592
93.0
PJD3_k127_3372563_4
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K12297
-
2.1.1.173,2.1.1.264
0.0
1439.0
PJD3_k127_3372563_5
Ammonium transporter
K03320
-
-
2.15e-259
800.0
PJD3_k127_3372563_6
esterase of the alpha-beta hydrolase superfamily
K07001
-
-
3.78e-244
754.0
PJD3_k127_3372563_7
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
K00254
-
1.3.5.2
3.098e-225
699.0
PJD3_k127_3372563_8
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
4.572e-223
693.0
PJD3_k127_3372563_9
-
-
-
-
1.29e-213
667.0
PJD3_k127_344372_0
DNA polymerase
K02337
-
2.7.7.7
0.0
2310.0
PJD3_k127_344372_1
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00281,K00283
-
1.4.4.2
0.0
1916.0
PJD3_k127_344372_10
ATPase components of ABC transporters with duplicated ATPase domains
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
K02169
-
2.1.1.197
2.237e-291
898.0
PJD3_k127_344372_15
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
K00833
-
2.6.1.62
6.751e-283
869.0
PJD3_k127_344372_16
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
K00652
-
2.3.1.47
5.542e-248
767.0
PJD3_k127_344372_17
Na H antiporter NhaD and related arsenite
-
-
-
2.507e-237
737.0
PJD3_k127_344372_18
The glycine cleavage system catalyzes the degradation of glycine
K00605
-
2.1.2.10
6.386e-235
728.0
PJD3_k127_344372_19
Major facilitator superfamily
-
-
-
6.941e-234
728.0
PJD3_k127_344372_2
Putative diguanylate phosphodiesterase
-
-
-
0.0
1613.0
PJD3_k127_344372_20
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
1.722e-224
702.0
PJD3_k127_344372_21
protein conserved in bacteria
K00243
-
-
1.785e-223
698.0
PJD3_k127_344372_22
Deacylase
K06987
-
-
2.732e-222
690.0
PJD3_k127_344372_23
COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000000000000003302
93.0
PJD3_k127_3531249_27
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K03525
-
2.7.1.33
0.000000000000000002321
94.0
PJD3_k127_3531249_3
MCRA family
K10254
-
4.2.1.53
0.0
1198.0
PJD3_k127_3531249_31
-
-
-
-
0.000194
46.0
PJD3_k127_3531249_4
COG1283 Na phosphate symporter
K03324
-
-
0.0
1080.0
PJD3_k127_3531249_5
-
-
-
-
0.0
1038.0
PJD3_k127_3531249_6
Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K01912
-
6.2.1.30
1.784e-243
756.0
PJD3_k127_3531249_7
PFAM Ion transport 2
K10716
-
-
2.694e-237
736.0
PJD3_k127_3531249_8
belongs to the carbohydrate kinase PfkB family
K00847,K00892
-
2.7.1.4,2.7.1.73
1.042e-206
644.0
PJD3_k127_3531249_9
Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
-
-
-
4.896e-205
647.0
PJD3_k127_3584511_0
Required for chromosome condensation and partitioning
K03529
-
-
0.0
2133.0
PJD3_k127_3584511_1
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
K03528
-
-
8.267e-240
744.0
PJD3_k127_3584511_2
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
K03657
-
3.6.4.12
0.0
1474.0
PJD3_k127_374385_1
Belongs to the GppA Ppx family
K01524
-
3.6.1.11,3.6.1.40
1.946e-311
956.0
PJD3_k127_374385_2
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
7.848e-268
825.0
PJD3_k127_374385_3
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
-
-
-
1.548e-236
732.0
PJD3_k127_374385_4
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0
1056.0
PJD3_k127_418943_1
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
3.651e-276
850.0
PJD3_k127_418943_2
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
0.0
1054.0
PJD3_k127_4197246_9
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
4.978e-277
852.0
PJD3_k127_4315232_4
molybdopterin
K03750
-
2.10.1.1
1.027e-250
775.0
PJD3_k127_4315232_5
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
2.807e-236
731.0
PJD3_k127_4315232_6
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Part of a membrane complex involved in electron transport
K03615
-
-
0.0
1324.0
PJD3_k127_4662968_50
COG1943 Transposase and inactivated derivatives
-
-
-
0.00001872
47.0
PJD3_k127_4662968_6
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.0000000000000000000000000000000000001509
141.0
PJD3_k127_4695011_73
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
0.00000000000000000000000000000000003286
134.0
PJD3_k127_4695011_74
glyoxalase bleomycin resistance protein dioxygenase
-
-
-
0.000000000000000000000000000006069
119.0
PJD3_k127_4695011_75
ATP synthase
K02116
-
-
0.0000000000000000000000001553
109.0
PJD3_k127_4695011_76
KAP family P-loop domain
-
-
-
0.0000000000000000004799
103.0
PJD3_k127_4695011_77
TRANSCRIPTIONal
-
-
-
0.0000000000000004062
82.0
PJD3_k127_4695011_79
Protein of unknown function (DUF2390)
-
-
-
0.000000005491
63.0
PJD3_k127_4695011_8
ABC transporter ATP-binding protein
K06158
-
-
0.0
1221.0
PJD3_k127_4695011_80
Protein of unknown function (DUF3575)
-
-
-
0.00000001067
64.0
PJD3_k127_4695011_9
-
-
-
-
0.0
1176.0
PJD3_k127_4730025_0
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1755.0
PJD3_k127_4730025_1
(Lipo)protein
K07121
-
-
0.0
1285.0
PJD3_k127_4730025_10
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
2.014e-262
811.0
PJD3_k127_4730025_11
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
5.841e-256
792.0
PJD3_k127_4730025_12
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
3.885e-255
788.0
PJD3_k127_4730025_13
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
8.062e-245
758.0
PJD3_k127_4730025_14
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
5.048e-244
755.0
PJD3_k127_4730025_15
Major facilitator superfamily
K07552
-
-
2.803e-243
753.0
PJD3_k127_4730025_16
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
3.616e-235
728.0
PJD3_k127_4730025_17
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
1.136e-231
717.0
PJD3_k127_4730025_18
Mediates influx of magnesium ions
K03284
-
-
1.326e-222
691.0
PJD3_k127_4730025_19
Phosphate starvation-inducible protein PhoH
K06217
-
-
4.675e-222
689.0
PJD3_k127_4730025_2
COG0457 FOG TPR repeat
-
-
-
0.0
1079.0
PJD3_k127_4730025_20
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
1.59e-221
688.0
PJD3_k127_4730025_21
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
K03438
-
2.1.1.199
1.304e-196
614.0
PJD3_k127_4730025_22
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K00948
-
2.7.6.1
3.504e-195
610.0
PJD3_k127_4730025_23
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K03589
-
-
0.000000000000000000065
99.0
PJD3_k127_4730025_6
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
1.727e-291
896.0
PJD3_k127_4730025_7
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
3.339e-291
897.0
PJD3_k127_4730025_8
Pyridine nucleotide-disulphide oxidoreductase
K17218
-
1.8.5.4
1.607e-283
871.0
PJD3_k127_4730025_9
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
9.134e-263
811.0
PJD3_k127_4758452_0
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1901.0
PJD3_k127_4758452_1
Putative diguanylate phosphodiesterase
K21025
-
-
0.0
1324.0
PJD3_k127_4758452_10
Major facilitator superfamily
-
-
-
3.095e-274
846.0
PJD3_k127_4758452_11
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
5.327e-272
839.0
PJD3_k127_4758452_12
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
K00121
-
1.1.1.1,1.1.1.284
1.116e-255
788.0
PJD3_k127_4758452_13
phosphoserine phosphatase
K01079
-
3.1.3.3
2.432e-252
780.0
PJD3_k127_4758452_14
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
2.987e-250
776.0
PJD3_k127_4758452_15
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K02502
-
-
7.84e-249
769.0
PJD3_k127_4758452_16
Response regulator containing a CheY-like receiver domain and a GGDEF domain
-
-
-
3.248e-239
741.0
PJD3_k127_4758452_17
HflC and HflK could encode or regulate a protease
K04088
-
-
1.423e-237
736.0
PJD3_k127_4758452_18
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
3.257e-232
719.0
PJD3_k127_4758452_19
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
K06176
-
5.4.99.27
7.34e-224
694.0
PJD3_k127_4758452_2
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
0.0
1205.0
PJD3_k127_4758452_20
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
K06949
-
3.1.3.100
1.328e-219
681.0
PJD3_k127_4758452_21
COG1943 Transposase and inactivated derivatives
-
-
-
4.205e-215
669.0
PJD3_k127_4758452_22
Flagellar motor protein
K02557
-
-
1.61e-214
667.0
PJD3_k127_4758452_23
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
5.095e-211
659.0
PJD3_k127_4758452_24
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
1.909e-209
651.0
PJD3_k127_4758452_25
lysine 2,3-aminomutase
K19810
-
-
1.44e-199
623.0
PJD3_k127_4758452_26
RNA polymerase sigma factor RpoS
K03087
-
-
1.459e-194
609.0
PJD3_k127_4758452_27
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily
With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.0000000001803
62.0
PJD3_k127_4758452_62
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K09880
-
3.1.3.77
0.0000000909
54.0
PJD3_k127_4758452_7
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
6.859e-303
933.0
PJD3_k127_4758452_8
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
1.06e-287
883.0
PJD3_k127_4758452_9
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
4.235e-278
858.0
PJD3_k127_4766339_0
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K12276
-
-
4.905e-228
719.0
PJD3_k127_4766339_1
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
K10680
-
-
4.879e-225
699.0
PJD3_k127_4766339_10
Belongs to the short-chain dehydrogenases reductases (SDR) family
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
-
-
-
0.000000000000000000000000000000000000004177
153.0
PJD3_k127_4780499_7
non-haem dioxygenase in morphine synthesis N-terminal
-
-
-
0.000000000000000000000000005351
113.0
PJD3_k127_4780499_8
ATP-dependent endonuclease of the OLD family
K07459
-
-
0.00000000000000000000000001307
109.0
PJD3_k127_4788949_0
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.00000000000000000000000000000000000001163
144.0
PJD3_k127_4788949_26
Belongs to the N-Me-Phe pilin family
K02650,K02655
-
-
0.000000000000000002903
91.0
PJD3_k127_4788949_3
His Kinase A (phosphoacceptor) domain
K07679,K20974
-
2.7.13.3
0.0
1159.0
PJD3_k127_4788949_4
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.0
1069.0
PJD3_k127_4788949_5
7TMR-DISM extracellular 2
-
-
-
0.0
1041.0
PJD3_k127_4788949_6
Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
K02558
-
6.3.2.45
1.044e-285
879.0
PJD3_k127_4788949_7
type II secretion system protein
K02653
-
-
4.553e-239
742.0
PJD3_k127_4788949_8
GGDEF domain
-
-
-
5.297e-237
735.0
PJD3_k127_4788949_9
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K03841
-
3.1.3.11
7.654e-204
636.0
PJD3_k127_4795112_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18989
-
-
0.0
1950.0
PJD3_k127_4795112_1
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01825
-
1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8
0.0
1404.0
PJD3_k127_4795112_11
Belongs to the 'phage' integrase family
-
-
-
0.00002042
46.0
PJD3_k127_4795112_2
mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
K15738
-
-
0.0
1234.0
PJD3_k127_4795112_3
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
9.302e-254
783.0
PJD3_k127_4795112_4
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1089.0
PJD3_k127_4804480_1
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
9.559e-274
843.0
PJD3_k127_4804480_30
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K09774
-
-
0.00000000000000000000003166
106.0
PJD3_k127_4804480_31
addiction module antidote protein
K07746
-
-
0.00000000000000000008614
91.0
PJD3_k127_4804480_4
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
2.798e-271
836.0
PJD3_k127_4804480_5
Acts as a magnesium transporter
K06213
-
-
2.16e-270
835.0
PJD3_k127_4804480_6
-
-
-
-
8.576e-252
778.0
PJD3_k127_4804480_7
Belongs to the peptidase S1C family
K04691,K04771,K04772
-
3.4.21.107
3.751e-241
749.0
PJD3_k127_4804480_8
Aminotransferase class I and II
K00817
-
2.6.1.9
1.314e-218
680.0
PJD3_k127_4804480_9
Arabinose 5-phosphate isomerase
K06041
-
5.3.1.13
9.35e-199
620.0
PJD3_k127_4821597_0
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000000000000000001746
108.0
PJD3_k127_4821597_3
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000000000001387
91.0
PJD3_k127_5010592_0
Biotin carboxylase
-
-
-
0.0
3275.0
PJD3_k127_5010592_1
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
0.0
2372.0
PJD3_k127_5010592_10
Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily
K00239
-
1.3.5.1,1.3.5.4
0.0
1193.0
PJD3_k127_5010592_11
Serine Threonine protein
-
-
-
0.0
1167.0
PJD3_k127_5010592_12
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K03581
-
3.1.11.5
0.0
1144.0
PJD3_k127_5010592_13
PepSY-associated TM region
-
-
-
0.0
1075.0
PJD3_k127_5010592_14
Glycerol-3-phosphate dehydrogenase
K00111,K21054
-
1.1.1.402,1.1.5.3
0.0
1035.0
PJD3_k127_5010592_15
PFAM glycosyl transferase family 39
-
-
-
3.5e-323
992.0
PJD3_k127_5010592_16
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K15576
-
-
4.681e-314
962.0
PJD3_k127_5010592_17
Nitrate nitrite transporter
K02575
-
-
5.14e-312
957.0
PJD3_k127_5010592_18
2-oxoglutarate dehydrogenase complex
K00382
-
1.8.1.4
2.022e-309
949.0
PJD3_k127_5010592_19
Belongs to the citrate synthase family
K01647
-
2.3.3.1
2.564e-285
878.0
PJD3_k127_5010592_2
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K03583
-
3.1.11.5
0.0
2326.0
PJD3_k127_5010592_20
catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP
K00647
-
2.3.1.41
3.491e-252
779.0
PJD3_k127_5010592_21
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
K00658
-
2.3.1.61
5.307e-247
765.0
PJD3_k127_5010592_22
reductase
K00362
-
1.7.1.15
2.166e-242
751.0
PJD3_k127_5010592_23
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
9.259e-241
745.0
PJD3_k127_5010592_24
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K22067
-
-
5.637e-240
743.0
PJD3_k127_5010592_25
Alginate export
-
-
-
4.525e-238
739.0
PJD3_k127_5010592_26
signal transduction protein containing EAL and modified HD-GYP domains
-
-
-
2.131e-234
728.0
PJD3_k127_5010592_27
COG0859 ADP-heptose LPS heptosyltransferase
K02841
-
-
3.538e-212
660.0
PJD3_k127_5010592_28
Belongs to the AlaDH PNT family
K00259
-
1.4.1.1
3.984e-210
656.0
PJD3_k127_5010592_29
ABC-type nitrate sulfonate bicarbonate transport system, permease component
K15577
-
-
2.199e-205
641.0
PJD3_k127_5010592_3
2-oxoglutarate dehydrogenase
K00164
-
1.2.4.2
0.0
1929.0
PJD3_k127_5010592_30
Two component signalling adaptor domain
K03415
-
-
3.957e-200
624.0
PJD3_k127_5010592_31
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0000000000000000000000002017
106.0
PJD3_k127_5159499_0
Succinylglutamate desuccinylase / Aspartoacylase family
K06987
-
-
1.088e-242
755.0
PJD3_k127_5159499_1
Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
-
-
-
0.0000000000000000000000000000000000146
137.0
PJD3_k127_518618_0
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01895
-
6.2.1.1
0.0
1345.0
PJD3_k127_518618_1
domain, Protein
-
-
-
3.06e-322
1015.0
PJD3_k127_518618_2
domain, Protein
-
-
-
5.595e-238
770.0
PJD3_k127_518618_3
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
0.0
1558.0
PJD3_k127_5267536_1
growth
-
-
-
0.0
1509.0
PJD3_k127_5267536_10
Catalyzes the reversible hydration of fumarate to (S)- malate
K01676
-
4.2.1.2
0.0
1022.0
PJD3_k127_5267536_11
Type IX secretion system membrane protein PorP/SprF
-
-
-
3.044e-312
961.0
PJD3_k127_5267536_12
Belongs to the UPF0229 family
K09786
-
-
7.167e-272
837.0
PJD3_k127_5267536_13
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
K00974
-
2.7.7.72
3.634e-263
813.0
PJD3_k127_5267536_14
Flagellar assembly protein T, middle domain
-
-
-
3.732e-239
741.0
PJD3_k127_5267536_15
-
-
-
-
3.959e-228
707.0
PJD3_k127_5267536_16
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K01409
-
2.3.1.234
7.388e-226
700.0
PJD3_k127_5267536_17
transcriptional regulator AraC family
-
-
-
4.428e-223
692.0
PJD3_k127_5267536_18
fatty acid desaturase
-
-
-
1.072e-216
674.0
PJD3_k127_5267536_19
phosphotransferase related to Ser Thr protein
K07102
-
2.7.1.221
2.547e-215
669.0
PJD3_k127_5267536_2
PrkA family serine protein kinase
K07180
-
-
0.0
1284.0
PJD3_k127_5267536_20
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K00097
-
1.1.1.262
1.669e-201
629.0
PJD3_k127_5267536_21
of the drug metabolite transporter (DMT) superfamily
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1155.0
PJD3_k127_5267536_7
Bacterial protein of unknown function (DUF839)
K07093
-
-
0.0
1080.0
PJD3_k127_5267536_8
7TMR-DISM extracellular 2
-
-
-
0.0
1074.0
PJD3_k127_5267536_9
SpoVR family
-
-
-
0.0
1047.0
PJD3_k127_5332509_0
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1770.0
PJD3_k127_5358386_10
Protein of unknown function (DUF1329)
-
-
-
3.882e-311
952.0
PJD3_k127_5358386_11
Deoxyguanosinetriphosphate triphosphohydrolase-like protein
Diadenosine tetraphosphatase and related serine threonine protein
-
-
-
7.328e-218
675.0
PJD3_k127_5358386_18
transcriptional regulator
-
-
-
1.981e-213
663.0
PJD3_k127_5358386_19
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
1.073e-212
662.0
PJD3_k127_5358386_2
aminopeptidase N
K01256
-
3.4.11.2
0.0
1709.0
PJD3_k127_5358386_20
hydrolase of the alpha beta-hydrolase fold
K07019
-
-
1.156e-206
644.0
PJD3_k127_5358386_21
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K06191
-
-
0.000000000000000000000000000000000000000008264
154.0
PJD3_k127_5358386_47
membrane protein (homolog of Drosophila rhomboid)
-
-
-
0.0000000000000000000000000003247
121.0
PJD3_k127_5358386_48
Domain of unknown function (DUF1853)
K09977
-
-
0.00000000000000000000000004887
119.0
PJD3_k127_5358386_49
-
-
-
-
0.00000000000000000004186
90.0
PJD3_k127_5358386_5
Double sensory domain of two-component sensor kinase
-
-
-
0.0
1449.0
PJD3_k127_5358386_50
protein conserved in bacteria
K09916
-
-
0.0000000000000005364
80.0
PJD3_k127_5358386_6
exporters of the RND superfamily
K07003
-
-
0.0
1377.0
PJD3_k127_5358386_7
Immune inhibitor A peptidase M6
-
-
-
0.0
1271.0
PJD3_k127_5358386_8
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1160.0
PJD3_k127_5358386_9
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1154.0
PJD3_k127_5428761_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1606.0
PJD3_k127_5428761_1
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
1533.0
PJD3_k127_5428761_10
COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K03307,K11928
-
-
1.262e-244
763.0
PJD3_k127_5428761_15
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
8.958e-238
736.0
PJD3_k127_5428761_16
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
1.642e-230
715.0
PJD3_k127_5428761_17
COG1538 Outer membrane protein
K12340
-
-
1.438e-220
692.0
PJD3_k127_5428761_18
glycyl-tRNA synthetase alpha subunit
K01878
-
6.1.1.14
2.714e-220
683.0
PJD3_k127_5428761_19
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
2.428e-218
689.0
PJD3_k127_5428761_2
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1494.0
PJD3_k127_5428761_20
Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
K03274
-
5.1.3.20
1.116e-216
672.0
PJD3_k127_5428761_21
Gluconolactonase
-
-
-
5.661e-211
657.0
PJD3_k127_5428761_22
Alpha/beta hydrolase family
-
-
-
7.728e-194
605.0
PJD3_k127_5428761_23
Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K07787
-
-
0.0
1958.0
PJD3_k127_5490862_1
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1948.0
PJD3_k127_5490862_10
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01950
-
6.3.5.1
0.0
1038.0
PJD3_k127_5490862_101
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K00969
-
2.7.7.18
0.00000000000000000000000000000000000000001465
160.0
PJD3_k127_5490862_102
Protein of unknown function (DUF465)
K09794
-
-
0.00000000000000000000000000000000000000005672
152.0
PJD3_k127_5490862_104
type IV pilus modification protein PilV
K02671
-
-
0.0000000000000000000000000000000000007427
146.0
PJD3_k127_5490862_106
Type IV minor pilin ComP, DNA uptake sequence receptor
K02655
-
-
0.000000000000000000000001736
108.0
PJD3_k127_5490862_108
COG4970 Tfp pilus assembly protein FimT
K08084
-
-
0.0000000000001392
78.0
PJD3_k127_5490862_109
Type II transport protein GspH
K08084
-
-
0.000000000003965
72.0
PJD3_k127_5490862_11
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.297e-319
981.0
PJD3_k127_5490862_110
Type IV Pilus-assembly protein W
K02672
-
-
0.00002238
55.0
PJD3_k127_5490862_112
Pilus assembly protein PilX
K02673
-
-
0.0001347
51.0
PJD3_k127_5490862_12
COG0464 ATPases of the AAA class
-
-
-
3.987e-313
960.0
PJD3_k127_5490862_13
Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
K02667
-
-
1.663e-265
821.0
PJD3_k127_5490862_17
Outer membrane efflux protein
-
-
-
1.161e-261
809.0
PJD3_k127_5490862_18
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
7.359e-257
792.0
PJD3_k127_5490862_19
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
4.469e-252
780.0
PJD3_k127_5490862_2
alginic acid biosynthetic process
K12287
-
-
0.0
1783.0
PJD3_k127_5490862_20
Glycosyltransferase Family 4
-
-
-
3.265e-244
756.0
PJD3_k127_5490862_21
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
8.399e-240
743.0
PJD3_k127_5490862_22
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
1.59e-237
735.0
PJD3_k127_5490862_23
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
6.062e-236
730.0
PJD3_k127_5490862_24
peptidase M42
-
-
-
2.005e-230
713.0
PJD3_k127_5490862_25
Glycosyltransferase Family 4
-
-
-
3.659e-230
715.0
PJD3_k127_5490862_26
Peptidoglycan polymerase that is essential for cell wall elongation
K05837
-
-
1.369e-227
707.0
PJD3_k127_5490862_27
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K02346
-
2.7.7.7
7.925e-226
700.0
PJD3_k127_5490862_28
Histidine kinase
K07708
-
2.7.13.3
1.374e-222
692.0
PJD3_k127_5490862_29
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K03644
-
2.8.1.8
5.037e-213
662.0
PJD3_k127_5490862_33
response regulator
-
-
-
4.168e-209
653.0
PJD3_k127_5490862_34
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
5.899e-208
647.0
PJD3_k127_5490862_35
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
3.983e-207
646.0
PJD3_k127_5490862_36
diguanylate cyclase activity
K18967,K20971
-
2.7.7.65
1.14e-205
641.0
PJD3_k127_5490862_37
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
0.0
1108.0
PJD3_k127_5490862_70
This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins
K03466
-
-
3.824e-231
716.0
PJD3_k127_5957165_1
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
0.000000000000000000000004578
102.0
PJD3_k127_5971578_0
DNA internalization-related competence protein ComEC Rec2
K02238
-
-
0.0
1195.0
PJD3_k127_5971578_1
Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
K01886
-
6.1.1.18
0.0
1167.0
PJD3_k127_5971578_10
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
0.0
1001.0
PJD3_k127_5971578_20
-
-
-
-
0.0000000000000004838
88.0
PJD3_k127_5971578_21
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
0.000000002254
57.0
PJD3_k127_5971578_3
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
5.831e-297
912.0
PJD3_k127_5971578_4
Lipoprotein releasing system, transmembrane protein
K09808
-
-
3.262e-252
781.0
PJD3_k127_5971578_5
Cell wall formation
K00075
-
1.3.1.98
2.426e-208
649.0
PJD3_k127_5971578_6
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
K00912
-
2.7.1.130
4.854e-208
649.0
PJD3_k127_5971578_7
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
-
-
-
2.141e-219
680.0
PJD3_k127_6031804_12
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K00766
-
2.4.2.18
5.307e-209
651.0
PJD3_k127_6031804_13
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
1.225e-321
985.0
PJD3_k127_6031804_7
Protein of unknown function (DUF1329)
-
-
-
2.901e-300
921.0
PJD3_k127_6031804_8
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
1.044e-242
752.0
PJD3_k127_6031804_9
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K01012
-
2.8.1.6
2.368e-225
700.0
PJD3_k127_6175_0
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K03580
-
-
0.0
1807.0
PJD3_k127_6175_1
Electron transfer flavoprotein-ubiquinone oxidoreductase
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
7.22e-315
965.0
PJD3_k127_6338238_10
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
2.274e-312
957.0
PJD3_k127_6338238_3
Involved in the processing of the 5'end of 16S rRNA
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2275.0
PJD3_k127_665960_1
Histidine kinase
-
-
-
0.0
2072.0
PJD3_k127_665960_10
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
2019.0
PJD3_k127_665960_20
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
0.0
996.0
PJD3_k127_665960_200
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
0.000000000002877
68.0
PJD3_k127_665960_201
TonB C terminal
K03646
-
-
0.000000000005482
76.0
PJD3_k127_665960_202
-
-
-
-
0.0000002518
54.0
PJD3_k127_665960_203
-
-
-
-
0.0000003243
53.0
PJD3_k127_665960_204
COG1943 Transposase and inactivated derivatives
-
-
-
0.0000007645
51.0
PJD3_k127_665960_205
-
-
-
-
0.0000007917
52.0
PJD3_k127_665960_208
TIGRFAM YD repeat protein
-
-
-
0.0007477
48.0
PJD3_k127_665960_21
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
5e-324
998.0
PJD3_k127_665960_22
Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K00036
-
1.1.1.363,1.1.1.49
4.301e-319
977.0
PJD3_k127_665960_23
COG0659 Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
5.879e-319
981.0
PJD3_k127_665960_24
COG0348 Polyferredoxin
-
-
-
4.506e-316
967.0
PJD3_k127_665960_25
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
1.466e-313
961.0
PJD3_k127_665960_26
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
1.289e-292
900.0
PJD3_k127_665960_27
ABC-type phosphate transport system, periplasmic component
K02040
-
-
7.775e-292
898.0
PJD3_k127_665960_28
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
1.56e-291
896.0
PJD3_k127_665960_29
Saccharopine dehydrogenase NADP binding domain
-
-
-
2.351e-288
886.0
PJD3_k127_665960_3
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1652.0
PJD3_k127_665960_30
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
6.538e-287
882.0
PJD3_k127_665960_31
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
3.175e-285
877.0
PJD3_k127_665960_32
COG1960 Acyl-CoA dehydrogenases
-
-
-
8.387e-285
875.0
PJD3_k127_665960_33
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
4.734e-278
862.0
PJD3_k127_665960_34
Involved in the TonB-independent uptake of proteins
K03641
-
-
1.172e-277
854.0
PJD3_k127_665960_35
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
K00351
-
1.6.5.8
1.101e-270
833.0
PJD3_k127_665960_36
Glycosyl transferase
K13693
-
2.4.1.266
2.185e-269
829.0
PJD3_k127_665960_37
Thiamine-phosphate pyrophosphorylase
K00941,K14153
-
2.5.1.3,2.7.1.49,2.7.4.7
1.156e-267
831.0
PJD3_k127_665960_38
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
3.995e-265
816.0
PJD3_k127_665960_39
HipA N-terminal domain
K07154
-
2.7.11.1
1.599e-263
814.0
PJD3_k127_665960_4
Histidine kinase
-
-
-
0.0
1504.0
PJD3_k127_665960_40
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
4.088e-256
790.0
PJD3_k127_665960_41
Fatty acid desaturase
K00507
-
1.14.19.1
6.788e-254
783.0
PJD3_k127_665960_42
protein of Photorhabdus and some similarities with
-
-
-
1.681e-240
782.0
PJD3_k127_665960_43
MacB-like periplasmic core domain
K02004
-
-
7.6e-239
743.0
PJD3_k127_665960_44
protein conserved in bacteria
K09919
-
-
3.482e-238
737.0
PJD3_k127_665960_45
FR47-like protein
-
-
-
1.572e-237
735.0
PJD3_k127_665960_46
amine dehydrogenase activity
-
-
-
3.363e-235
746.0
PJD3_k127_665960_47
MacB-like periplasmic core domain
K02004
-
-
6.505e-234
726.0
PJD3_k127_665960_48
fatty acid desaturase
K00508
-
1.14.19.3
1.285e-231
719.0
PJD3_k127_665960_49
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K01589
-
6.3.4.18
2.43e-225
699.0
PJD3_k127_665960_5
P-type ATPase
K01533
-
3.6.3.4
0.0
1454.0
PJD3_k127_665960_50
Histidine kinase
-
-
-
1.144e-224
698.0
PJD3_k127_665960_51
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
4.589e-220
683.0
PJD3_k127_665960_52
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K02005
-
-
2.194e-218
681.0
PJD3_k127_665960_53
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
2.29e-218
678.0
PJD3_k127_665960_54
phage tail tape measure protein
-
-
-
2.456e-214
730.0
PJD3_k127_665960_55
polysaccharide deacetylase
-
-
-
8.78e-214
666.0
PJD3_k127_665960_56
FAD dependent oxidoreductase
K03153
-
1.4.3.19
1.848e-212
665.0
PJD3_k127_665960_57
AraC family transcriptional regulator
-
-
-
3.157e-211
658.0
PJD3_k127_665960_58
Permease
K03548
-
-
7.038e-210
654.0
PJD3_k127_665960_59
protein of Photorhabdus and some similarities with
-
-
-
2.909e-207
688.0
PJD3_k127_665960_6
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1450.0
PJD3_k127_665960_60
diguanylate cyclase activity
-
-
-
1.017e-206
647.0
PJD3_k127_665960_61
AraC family transcriptional regulator
-
-
-
8.394e-204
636.0
PJD3_k127_665960_62
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
K00406
-
-
4.685e-203
631.0
PJD3_k127_665960_63
COG0798 Arsenite efflux pump ACR3 and related permeases
K03325
-
-
7.765e-203
632.0
PJD3_k127_665960_64
GGDEF domain
-
-
-
9.416e-201
626.0
PJD3_k127_665960_65
COG4240 Predicted kinase
K15918
-
2.7.1.31
1.501e-198
621.0
PJD3_k127_665960_66
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
K00265
-
1.4.1.13,1.4.1.14
0.0
2987.0
PJD3_k127_673710_1
NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit
K05559
-
-
0.0
1738.0
PJD3_k127_673710_10
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
-
-
-
2.093e-303
933.0
PJD3_k127_673710_11
Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit
K05561
-
-
3.105e-298
917.0
PJD3_k127_673710_12
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
7.794e-296
908.0
PJD3_k127_673710_13
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
5.957e-278
857.0
PJD3_k127_673710_14
ATPases associated with a variety of cellular activities
K05776
-
-
9.185e-274
846.0
PJD3_k127_673710_15
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
1.307e-259
803.0
PJD3_k127_673710_16
PFAM Metal-dependent phosphohydrolase, HD
-
-
-
7.77e-242
751.0
PJD3_k127_673710_17
AAA domain
K03112
-
-
5.426e-232
726.0
PJD3_k127_673710_18
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
6.18e-232
719.0
PJD3_k127_673710_19
Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K01735
-
4.2.3.4
2.004e-227
706.0
PJD3_k127_673710_2
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000000000000000000000000002276
142.0
PJD3_k127_673710_57
Multiple resistance and pH regulation protein F (MrpF / PhaF)
K05563
-
-
0.0000000000000000000000003725
107.0
PJD3_k127_673710_6
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
0.0
1225.0
PJD3_k127_673710_7
glutamate synthase
K00266
-
1.4.1.13,1.4.1.14
6.854e-316
967.0
PJD3_k127_673710_8
FAD linked oxidase
-
-
-
1.953e-306
940.0
PJD3_k127_673710_9
Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
-
-
-
4.838e-305
939.0
PJD3_k127_735625_0
Monooxygenase, flavin-binding family
-
-
-
9.365e-295
904.0
PJD3_k127_735625_1
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
1.276e-288
887.0
PJD3_k127_772913_3
regulator
-
-
-
2.251e-285
878.0
PJD3_k127_772913_4
Aminotransferase
-
-
-
8.455e-240
747.0
PJD3_k127_772913_5
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K08963
-
5.3.1.23
2.564e-208
649.0
PJD3_k127_772913_6
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1765.0
PJD3_k127_806672_10
homoserine dehydrogenase
K00003
-
1.1.1.3
2.544e-265
819.0
PJD3_k127_806672_11
Response regulator containing a CheY-like receiver domain and an HD-GYP domain
-
-
-
1.874e-248
771.0
PJD3_k127_806672_12
fatty acid desaturase
-
-
-
4.45e-244
754.0
PJD3_k127_806672_13
HI0933-like protein
K07007
-
-
1.715e-243
754.0
PJD3_k127_806672_14
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
-
-
-
2.436e-233
723.0
PJD3_k127_806672_15
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
1.827e-231
721.0
PJD3_k127_806672_16
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K01488,K21053
-
3.5.4.2,3.5.4.4
1.205e-228
708.0
PJD3_k127_806672_17
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
K01465
-
3.5.2.3
2.668e-225
699.0
PJD3_k127_806672_18
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
5.194e-225
700.0
PJD3_k127_806672_19
ABC transporter substrate-binding protein PnrA-like
K02058
-
-
1.111e-224
698.0
PJD3_k127_806672_2
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
0.0
1693.0
PJD3_k127_806672_20
Belongs to the ompA family
K21218
-
-
2.965e-208
648.0
PJD3_k127_806672_21
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K02051
-
-
1.915e-203
634.0
PJD3_k127_806672_22
transcriptional regulator
-
-
-
6.678e-203
632.0
PJD3_k127_806672_23
Binding-protein-dependent transport system inner membrane component
K02050
-
-
9.148e-196
612.0
PJD3_k127_806672_24
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K02536
-
2.3.1.191
8.921e-195
610.0
PJD3_k127_806672_25
Belongs to the pseudouridine synthase RsuA family
K06182
-
5.4.99.21
3.145e-194
608.0
PJD3_k127_806672_26
Belongs to the glucose-6-phosphate 1-epimerase family
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
2030.0
PJD3_k127_819668_10
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
1.253e-269
833.0
PJD3_k127_819668_11
-
-
-
-
7.647e-261
804.0
PJD3_k127_819668_12
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
2.045e-255
790.0
PJD3_k127_819668_13
Sulfatase-modifying factor enzyme 1
-
-
-
3.745e-255
788.0
PJD3_k127_819668_14
cytochrome d ubiquinol oxidase, subunit
K00426
-
1.10.3.14
1.971e-245
759.0
PJD3_k127_819668_15
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
1.01e-229
713.0
PJD3_k127_819668_16
-
-
-
-
1.438e-212
663.0
PJD3_k127_819668_17
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03040
-
2.7.7.6
7.555e-212
659.0
PJD3_k127_819668_18
COG2070 Dioxygenases related to 2-nitropropane dioxygenase
K00459,K02371
-
1.13.12.16,1.3.1.9
4.134e-207
646.0
PJD3_k127_819668_19
MATE efflux family protein
K03327
-
-
1.175e-206
652.0
PJD3_k127_819668_2
Lamin Tail Domain
K07004
-
-
0.0
1747.0
PJD3_k127_819668_20
Cobalamin synthesis protein cobW C-terminal domain
-
-
-
1.535e-201
629.0
PJD3_k127_819668_21
with the alpha beta hydrolase fold
K01046
-
3.1.1.3
5.341e-200
625.0
PJD3_k127_819668_22
COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
1.158e-298
917.0
PJD3_k127_819668_70
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.0000000000000000000000000000000000000000004874
157.0
PJD3_k127_819668_9
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0
1074.0
PJD3_k127_83098_2
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
0.0
1014.0
PJD3_k127_83098_3
Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
K14267
-
2.6.1.17
2.127e-265
817.0
PJD3_k127_83098_4
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
K01887
-
6.1.1.19
0.0
1116.0
PJD3_k127_833982_5
-
-
-
-
0.0
1007.0
PJD3_k127_833982_6
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
