Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
K02913
-
-
0.0000000000000000000000000004305
113.0
PJS3_k127_1315254_12
Belongs to the Glu Leu Phe Val dehydrogenases family
-
-
-
1.861e-309
949.0
PJS3_k127_1315254_120
-
-
-
-
0.000000000000000000000004775
111.0
PJS3_k127_1315254_121
sequence-specific DNA binding
-
-
-
0.000000000000000000001912
97.0
PJS3_k127_1315254_122
transcriptional regulator
K07733
-
-
0.00000000000000000007956
90.0
PJS3_k127_1315254_124
Pilus assembly protein CpaB
K02279
-
-
0.00000000000000005431
91.0
PJS3_k127_1315254_127
COG3039 Transposase and inactivated derivatives IS5 family
K07481
-
-
0.00009159
48.0
PJS3_k127_1315254_128
-
-
-
-
0.0004264
51.0
PJS3_k127_1315254_13
Putative Flp pilus-assembly TadE/G-like
-
-
-
4.103e-307
951.0
PJS3_k127_1315254_14
cytochrome p450
-
-
-
3.585e-303
932.0
PJS3_k127_1315254_15
Peptidase, M16
K00960,K07263
-
2.7.7.6
7.218e-303
934.0
PJS3_k127_1315254_16
COG2067 Long-chain fatty acid transport protein
-
-
-
1.985e-282
869.0
PJS3_k127_1315254_17
Long-chain fatty acid transport protein
K06076
-
-
1.572e-278
857.0
PJS3_k127_1315254_18
flavoprotein involved in K transport
-
-
-
5.342e-278
856.0
PJS3_k127_1315254_19
Belongs to the peptidase M16 family
K07263
-
-
1.639e-277
854.0
PJS3_k127_1315254_2
phosphomannomutase
K15778
-
5.4.2.2,5.4.2.8
0.0
1428.0
PJS3_k127_1315254_20
Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine
K00641
-
2.3.1.31
1.081e-266
822.0
PJS3_k127_1315254_21
Belongs to the 'phage' integrase family
-
-
-
2.555e-262
809.0
PJS3_k127_1315254_22
Reductase C-terminal
K00529
-
1.18.1.3
1.273e-261
809.0
PJS3_k127_1315254_23
Major facilitator superfamily
-
-
-
5.981e-260
803.0
PJS3_k127_1315254_24
COG1398 Fatty-acid desaturase
-
-
-
1.544e-256
795.0
PJS3_k127_1315254_25
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
1.904e-255
789.0
PJS3_k127_1315254_26
COG4963 Flp pilus assembly protein, ATPase CpaE
-
-
-
3.487e-248
767.0
PJS3_k127_1315254_27
acyl-CoA dehydrogenase
-
-
-
4.1e-245
758.0
PJS3_k127_1315254_28
COG4962 Flp pilus assembly protein, ATPase CpaF
K02283
-
-
1.156e-240
745.0
PJS3_k127_1315254_29
Belongs to the GSP D family
K02280
-
-
9.434e-238
739.0
PJS3_k127_1315254_3
N-methylhydantoinase A acetone carboxylase, beta subunit
K01469,K01473
-
3.5.2.14,3.5.2.9
0.0
1172.0
PJS3_k127_1315254_30
acetyltransferases and hydrolases with the alpha beta hydrolase fold
-
-
-
2.596e-237
734.0
PJS3_k127_1315254_31
Usher protein
K07347
-
-
2.29e-236
758.0
PJS3_k127_1315254_32
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
2.847e-206
646.0
PJS3_k127_1315254_37
Serine threonine protein kinase
K08282,K12132
-
2.7.11.1
6.007e-203
632.0
PJS3_k127_1315254_38
Part of the ABC transporter FtsEX involved in cellular division
K09811
-
-
6.332e-203
634.0
PJS3_k127_1315254_39
Domain of unknown function (DUF932)
-
-
-
1.365e-202
633.0
PJS3_k127_1315254_4
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1515.0
PJS3_k127_2021255_10
transferase activity, transferring glycosyl groups
-
-
-
6.822e-219
682.0
PJS3_k127_2021255_11
Polysaccharide biosynthesis/export protein
K01991
-
-
2.195e-202
634.0
PJS3_k127_2021255_12
Polysaccharide biosynthesis protein
K15894
-
4.2.1.115
1.112e-195
612.0
PJS3_k127_2021255_13
Belongs to the cysteine synthase cystathionine beta- synthase family
protein involved in exopolysaccharide biosynthesis
K16554,K16692
-
-
0.0
1229.0
PJS3_k127_2021255_30
O-antigen polysaccharide polymerase Wzy
-
-
-
0.0005807
52.0
PJS3_k127_2021255_4
Polysaccharide biosynthesis protein
-
-
-
0.0
1057.0
PJS3_k127_2021255_5
COG0471 Di- and tricarboxylate transporters
-
-
-
0.0
1041.0
PJS3_k127_2021255_6
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA
K03215
-
2.1.1.190
6.554e-293
901.0
PJS3_k127_2021255_7
Capsule assembly protein Wzi
-
-
-
1.643e-276
855.0
PJS3_k127_2021255_8
Belongs to the UDP-N-acetylglucosamine 2-epimerase family
-
-
-
8.626e-240
742.0
PJS3_k127_2021255_9
COG0451 Nucleoside-diphosphate-sugar epimerases
K19068
-
1.1.1.367
2.074e-220
688.0
PJS3_k127_2128372_0
Histidine kinase
-
-
-
0.0
1903.0
PJS3_k127_2128372_1
cellulase activity
K20276
-
-
0.0
1557.0
PJS3_k127_2128372_10
Aminotransferase
-
-
-
3.798e-234
727.0
PJS3_k127_2128372_11
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K00145
-
1.2.1.38
1.65e-224
702.0
PJS3_k127_2128372_12
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
-
-
-
3.352e-210
654.0
PJS3_k127_2128372_13
belongs to the carbohydrate kinase PfkB family
K00847,K00892
-
2.7.1.4,2.7.1.73
4.134e-207
646.0
PJS3_k127_2128372_14
Mur ligase family, catalytic domain
K02558
-
6.3.2.45
1.903e-206
655.0
PJS3_k127_2128372_15
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
K00970
-
2.7.7.19
3.578e-294
903.0
PJS3_k127_2128372_6
regulator
-
-
-
2.158e-282
869.0
PJS3_k127_2128372_7
Glutamate-1-semialdehyde aminotransferase
K01845
-
5.4.3.8
1.446e-271
838.0
PJS3_k127_2128372_8
Peptidase M23
-
-
-
6.801e-271
837.0
PJS3_k127_2128372_9
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
2.326e-241
748.0
PJS3_k127_2196468_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18303
-
-
0.0
1925.0
PJS3_k127_2196468_1
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K15726
-
-
0.0
1924.0
PJS3_k127_2196468_10
COG5265 ABC-type transport system involved in Fe-S cluster assembly permease and ATPase components
K06147
-
-
0.0
1095.0
PJS3_k127_2196468_100
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases
-
-
-
1.976e-289
891.0
PJS3_k127_2196468_2
Belongs to the PEP-utilizing enzyme family
K08484
-
2.7.3.9
0.0
1473.0
PJS3_k127_2196468_20
Peptidase family M20/M25/M40
-
-
-
3.049e-283
872.0
PJS3_k127_2196468_21
COG0642 Signal transduction histidine kinase
K07641
-
2.7.13.3
3.131e-281
867.0
PJS3_k127_2196468_22
Belongs to the DEAD box helicase family
-
-
-
1.241e-279
861.0
PJS3_k127_2196468_23
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
3.483e-275
851.0
PJS3_k127_2196468_24
Inner membrane protein involved in colicin E2 resistance
K06143
-
-
7.929e-264
816.0
PJS3_k127_2196468_25
COG2199 FOG GGDEF domain
-
-
-
1.179e-248
768.0
PJS3_k127_2196468_26
Belongs to the 'phage' integrase family
-
-
-
2.373e-245
759.0
PJS3_k127_2196468_27
molybdopterin
K03750
-
2.10.1.1
4.438e-241
754.0
PJS3_k127_2196468_28
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid
K00130
-
1.2.1.8
9.926e-241
753.0
PJS3_k127_2196468_29
Outer membrane efflux protein
-
-
-
8.784e-237
735.0
PJS3_k127_2196468_3
P-type ATPase
K17686
-
3.6.3.54
0.0
1416.0
PJS3_k127_2196468_30
poly(3-hydroxybutyrate) depolymerase activity
K07019
-
-
2.492e-230
715.0
PJS3_k127_2196468_31
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
7.847e-228
710.0
PJS3_k127_2196468_32
Mechanosensitive ion channel
-
-
-
1.339e-222
691.0
PJS3_k127_2196468_33
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K18302
-
-
5.679e-219
682.0
PJS3_k127_2196468_34
COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain
-
-
-
2.667e-211
665.0
PJS3_k127_2196468_35
COG1943 Transposase and inactivated derivatives
-
-
-
1.739e-209
651.0
PJS3_k127_2196468_36
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
1.483e-206
645.0
PJS3_k127_2196468_37
COG0656 Aldo keto reductases, related to diketogulonate reductase
K00002
-
1.1.1.2
3.648e-204
643.0
PJS3_k127_2196468_38
iron ion transport
K02016,K07225
-
-
4.643e-204
637.0
PJS3_k127_2196468_39
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K03639
-
4.1.99.22
1.458e-203
636.0
PJS3_k127_2196468_4
Patatin-like phospholipase
-
-
-
0.0
1287.0
PJS3_k127_2196468_40
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
COG2070 Dioxygenases related to 2-nitropropane dioxygenase
K00459
-
1.13.12.16
4.253e-201
627.0
PJS3_k127_2196468_43
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Subunit R is required for both nuclease and ATPase activities, but not for modification
K01153
-
3.1.21.3
0.0
1776.0
PJS3_k127_256100_100
Belongs to the thiolase family
K00626
-
2.3.1.9
8.546e-274
844.0
PJS3_k127_256100_101
Belongs to the GARS family
K01945
-
6.3.4.13
3.012e-271
835.0
PJS3_k127_256100_102
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K03732
-
3.6.4.13
1.374e-269
833.0
PJS3_k127_256100_103
COG0477 Permeases of the major facilitator superfamily
-
-
-
1.462e-269
831.0
PJS3_k127_256100_104
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
K21071
-
2.7.1.11,2.7.1.90
2.693e-269
829.0
PJS3_k127_256100_105
Histidine kinase
K15011
-
2.7.13.3
4.738e-269
830.0
PJS3_k127_256100_106
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
-
-
-
7.964e-269
828.0
PJS3_k127_256100_107
Dihydroorotase multifunctional complex type
K01465
-
3.5.2.3
2.119e-268
829.0
PJS3_k127_256100_108
COG1960 Acyl-CoA dehydrogenases
-
-
-
5.701e-267
823.0
PJS3_k127_256100_109
Iron-regulated membrane protein
-
-
-
8.183e-267
822.0
PJS3_k127_256100_11
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1725.0
PJS3_k127_256100_110
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02275
-
1.9.3.1
5.885e-266
820.0
PJS3_k127_256100_111
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
3.738e-264
818.0
PJS3_k127_256100_112
protein conserved in bacteria
-
-
-
1.556e-263
812.0
PJS3_k127_256100_113
Curli production assembly/transport component CsgG
-
-
-
2.961e-262
810.0
PJS3_k127_256100_114
SPFH domain / Band 7 family
-
-
-
3.024e-262
811.0
PJS3_k127_256100_115
containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
-
-
-
3.536e-262
813.0
PJS3_k127_256100_116
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
K00974
-
2.7.7.72
8.284e-262
808.0
PJS3_k127_256100_117
COG0642 Signal transduction histidine kinase
-
-
-
5.434e-261
805.0
PJS3_k127_256100_118
MATE efflux family protein
K03327
-
-
1.228e-260
805.0
PJS3_k127_256100_119
-
-
-
-
1.35e-260
819.0
PJS3_k127_256100_12
Histidine kinase
K20972,K20973
-
2.7.13.3
0.0
1725.0
PJS3_k127_256100_120
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
7.192e-260
803.0
PJS3_k127_256100_121
histidyl-tRNA synthetase
K01892
-
6.1.1.21
5.465e-258
798.0
PJS3_k127_256100_122
sodium proton antiporter
K07084
-
-
2.14e-257
801.0
PJS3_k127_256100_123
Periplasmic binding protein domain
K01999,K11959
-
-
2.647e-256
792.0
PJS3_k127_256100_124
Protein of unknown function (DUF3570)
-
-
-
2.091e-255
792.0
PJS3_k127_256100_125
Belongs to the aspartokinase family
K00928
-
2.7.2.4
3.259e-255
788.0
PJS3_k127_256100_126
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
5.831e-254
783.0
PJS3_k127_256100_127
protein conserved in bacteria
-
-
-
6.739e-254
785.0
PJS3_k127_256100_128
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
1.991e-253
784.0
PJS3_k127_256100_129
Belongs to the UPF0229 family
K09786
-
-
4.104e-252
781.0
PJS3_k127_256100_13
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1692.0
PJS3_k127_256100_130
COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
K09015
-
-
5.486e-251
786.0
PJS3_k127_256100_131
AAA ATPase domain
-
-
-
8.641e-250
771.0
PJS3_k127_256100_132
Neuraminidase (sialidase)
-
-
-
1.869e-249
773.0
PJS3_k127_256100_133
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K19804
-
-
2.232e-249
773.0
PJS3_k127_256100_134
Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05916
-
1.14.12.17
3.254e-249
771.0
PJS3_k127_256100_135
fatty acid desaturase
-
-
-
3.408e-249
771.0
PJS3_k127_256100_136
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
8.818e-249
768.0
PJS3_k127_256100_137
flavoprotein involved in K transport
-
-
-
9.62e-249
775.0
PJS3_k127_256100_138
COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family
-
-
-
3.387e-246
761.0
PJS3_k127_256100_139
COG3000 Sterol desaturase
K00227
-
1.14.19.20
6.36e-246
760.0
PJS3_k127_256100_14
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
K01869
-
6.1.1.4
0.0
1641.0
PJS3_k127_256100_140
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Succinylglutamate desuccinylase / Aspartoacylase family
K06987
-
-
5.548e-243
757.0
PJS3_k127_256100_146
Bacterial protein of unknown function (DUF853)
K06915
-
-
5.023e-242
754.0
PJS3_k127_256100_147
proteolysis
K19225
-
3.4.21.105
7.874e-242
753.0
PJS3_k127_256100_148
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K17713
-
-
4.612e-241
745.0
PJS3_k127_256100_149
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
8.387e-240
745.0
PJS3_k127_256100_15
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1604.0
PJS3_k127_256100_150
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
-
-
-
2.004e-239
742.0
PJS3_k127_256100_151
6-phosphogluconolactonase activity
K07404
-
3.1.1.31
2.674e-239
760.0
PJS3_k127_256100_152
COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
-
-
-
6.131e-239
739.0
PJS3_k127_256100_153
-
-
-
-
1.249e-238
742.0
PJS3_k127_256100_154
Belongs to the peptidase S11 family
K07258
-
3.4.16.4
3.825e-238
740.0
PJS3_k127_256100_155
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
K04487
-
2.8.1.7
2.221e-237
736.0
PJS3_k127_256100_156
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K00831
-
2.6.1.52
2.648e-236
731.0
PJS3_k127_256100_157
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates
K01426
-
3.5.1.4
1.308e-235
728.0
PJS3_k127_256100_158
Protein of unknown function (DUF3426)
-
-
-
7.293e-235
730.0
PJS3_k127_256100_159
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
2.595e-233
724.0
PJS3_k127_256100_16
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K03555
-
-
0.0
1572.0
PJS3_k127_256100_160
Prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
6.665e-233
721.0
PJS3_k127_256100_161
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.124e-232
721.0
PJS3_k127_256100_162
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K03526
-
1.17.7.1,1.17.7.3
1.206e-232
722.0
PJS3_k127_256100_163
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
3.045e-230
715.0
PJS3_k127_256100_164
Belongs to the ompA family
K03286
-
-
1.405e-229
713.0
PJS3_k127_256100_165
Peptidoglycan polymerase that is essential for cell wall elongation
K05837
-
-
1.208e-228
710.0
PJS3_k127_256100_166
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K06917
-
-
2.811e-228
709.0
PJS3_k127_256100_167
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
5.953e-228
707.0
PJS3_k127_256100_168
protein conserved in bacteria
K09919
-
-
2.621e-227
705.0
PJS3_k127_256100_169
COG1960 Acyl-CoA dehydrogenases
-
-
-
5.251e-227
705.0
PJS3_k127_256100_17
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
0.0
1520.0
PJS3_k127_256100_170
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
1.354e-225
702.0
PJS3_k127_256100_171
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
7.804e-225
699.0
PJS3_k127_256100_172
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
4.936e-224
695.0
PJS3_k127_256100_173
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
K01465
-
3.5.2.3
1.577e-222
692.0
PJS3_k127_256100_174
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
2.462e-222
690.0
PJS3_k127_256100_175
Glutathione S-transferase
K07393
-
1.8.5.7
1.532e-221
689.0
PJS3_k127_256100_176
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K03771
-
5.2.1.8
4.307e-221
692.0
PJS3_k127_256100_177
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K02051
-
-
5.814e-221
686.0
PJS3_k127_256100_178
Protein conserved in bacteria
K09927
-
-
8.383e-221
689.0
PJS3_k127_256100_179
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K03684
-
3.1.13.5
1.818e-220
685.0
PJS3_k127_256100_18
Dicarboxylate transport
-
-
-
0.0
1519.0
PJS3_k127_256100_180
Belongs to the binding-protein-dependent transport system permease family
K11961
-
-
6.514e-220
685.0
PJS3_k127_256100_181
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
1.376e-219
687.0
PJS3_k127_256100_182
Pfam:HipA_N
K07154
-
2.7.11.1
2.351e-219
685.0
PJS3_k127_256100_183
transcriptional regulator
-
-
-
4.12e-219
680.0
PJS3_k127_256100_184
-
-
-
-
7.512e-219
683.0
PJS3_k127_256100_185
glycyl-tRNA synthetase alpha subunit
K01878
-
6.1.1.14
2.129e-218
679.0
PJS3_k127_256100_186
Zn-dependent hydrolases of the beta-lactamase fold
-
-
-
3.999e-218
681.0
PJS3_k127_256100_187
Cyclopropane fatty acid synthase and related
K00574
-
2.1.1.79
4.793e-218
681.0
PJS3_k127_256100_188
hydrolase of the alpha beta-hydrolase fold
K07019
-
-
2.389e-217
676.0
PJS3_k127_256100_189
Lytic murein transglycosylase B
K08305
-
-
2.4e-217
678.0
PJS3_k127_256100_19
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.0
1514.0
PJS3_k127_256100_190
Protein of unknown function (DUF2804)
-
-
-
2.622e-217
676.0
PJS3_k127_256100_191
phosphotransferase related to Ser Thr protein
K07102
-
2.7.1.221
8.606e-216
670.0
PJS3_k127_256100_192
protein required for cytochrome oxidase assembly
K02259
-
-
2.851e-215
670.0
PJS3_k127_256100_193
COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
K06597
-
-
2.897e-215
669.0
PJS3_k127_256100_194
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
5.962e-215
670.0
PJS3_k127_256100_195
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K03644
-
2.8.1.8
1.093e-214
668.0
PJS3_k127_256100_196
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
-
-
-
1.209e-212
661.0
PJS3_k127_256100_197
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134,K03472
-
1.2.1.12,1.2.1.72
1.904e-212
661.0
PJS3_k127_256100_198
Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain
-
-
-
2.244e-212
660.0
PJS3_k127_256100_199
Belongs to the ompA family
K03286
-
-
9.707e-212
662.0
PJS3_k127_256100_2
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
0.0
2337.0
PJS3_k127_256100_20
redox protein, regulator of disulfide bond formation
K09136
-
-
0.0
1444.0
PJS3_k127_256100_200
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
2.392e-211
658.0
PJS3_k127_256100_201
protein conserved in bacteria
-
-
-
2.748e-211
658.0
PJS3_k127_256100_202
DNA polymerase III
K02340
-
2.7.7.7
2.772e-211
659.0
PJS3_k127_256100_203
-
-
-
-
5.092e-211
663.0
PJS3_k127_256100_204
Fe-S oxidoreductases
-
-
-
3.021e-207
644.0
PJS3_k127_256100_205
Belongs to the prokaryotic GSH synthase family
K01920
-
6.3.2.3
6.309e-207
644.0
PJS3_k127_256100_206
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K00766
-
2.4.2.18
9.343e-207
645.0
PJS3_k127_256100_207
acetyltransferases and hydrolases with the alpha beta hydrolase fold
K01046
-
3.1.1.3
4.534e-206
641.0
PJS3_k127_256100_208
Phosphate starvation-inducible protein PhoH
K06217
-
-
9.654e-206
642.0
PJS3_k127_256100_209
COG2070 Dioxygenases related to 2-nitropropane dioxygenase
K00459
-
1.13.12.16
1.109e-205
642.0
PJS3_k127_256100_21
transport system, large permease component
-
-
-
0.0
1415.0
PJS3_k127_256100_210
Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02297
-
1.10.3.10
1.156e-202
632.0
PJS3_k127_256100_214
Lipid A biosynthesis acyltransferase
K02517
-
2.3.1.241
1.458e-202
632.0
PJS3_k127_256100_215
Putative peptidoglycan binding domain
-
-
-
7.28e-200
627.0
PJS3_k127_256100_216
AraC family transcriptional regulator
-
-
-
1.421e-199
625.0
PJS3_k127_256100_217
TRAP-type C4-dicarboxylate transport system periplasmic component
-
-
-
1.379e-198
621.0
PJS3_k127_256100_218
Domain of unknown function (DUF3541)
-
-
-
1.176e-197
621.0
PJS3_k127_256100_219
Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K14540
-
-
9.486e-195
614.0
PJS3_k127_256100_22
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA
K00219
-
1.3.1.34
0.0
1346.0
PJS3_k127_256100_240
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
0.0
1112.0
PJS3_k127_256100_450
COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
0.0
1111.0
PJS3_k127_256100_460
Belongs to the short-chain dehydrogenases reductases (SDR) family
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0
1095.0
PJS3_k127_256100_490
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
-
-
-
0.0003034
46.0
PJS3_k127_256100_62
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K03307
-
-
0.0
1011.0
PJS3_k127_256100_63
Bifunctional purine biosynthesis protein PurH
K00602
-
2.1.2.3,3.5.4.10
0.0
1002.0
PJS3_k127_256100_65
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Transfers the fatty acyl group on membrane lipoproteins
K03820
-
-
1.824e-313
962.0
PJS3_k127_256100_71
SpoVR family
-
-
-
4.63e-311
956.0
PJS3_k127_256100_72
COG3639 ABC-type phosphate phosphonate transport system, permease component
K02042
-
-
3.074e-309
951.0
PJS3_k127_256100_73
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
9.324e-309
947.0
PJS3_k127_256100_74
COG0464 ATPases of the AAA class
-
-
-
1.594e-306
941.0
PJS3_k127_256100_75
COG0286 Type I restriction-modification system methyltransferase subunit
K03427
-
2.1.1.72
1.386e-304
941.0
PJS3_k127_256100_76
FAD linked oxidase
-
-
-
2.959e-304
934.0
PJS3_k127_256100_77
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
4.33e-304
933.0
PJS3_k127_256100_78
lysine 2,3-aminomutase
-
-
-
6.124e-303
929.0
PJS3_k127_256100_79
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
1.122e-299
920.0
PJS3_k127_256100_8
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K03580
-
-
0.0
1907.0
PJS3_k127_256100_80
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
5.054e-299
922.0
PJS3_k127_256100_81
Protein of unknown function (DUF1298)
K00635
-
2.3.1.20
5.517e-299
919.0
PJS3_k127_256100_82
COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
K00059
-
1.1.1.100
4.57e-297
914.0
PJS3_k127_256100_83
An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
K01961
-
6.3.4.14,6.4.1.2
2.178e-295
906.0
PJS3_k127_256100_84
unusual protein kinase
-
-
-
5.059e-293
900.0
PJS3_k127_256100_85
alpha beta
-
-
-
5.458e-293
919.0
PJS3_k127_256100_86
D-alanyl-D-alanine carboxypeptidase
K07259
-
3.4.16.4
2.566e-291
898.0
PJS3_k127_256100_87
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
1.99e-290
892.0
PJS3_k127_256100_88
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
9.097e-290
891.0
PJS3_k127_256100_89
Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
K02558
-
6.3.2.45
1.487e-289
891.0
PJS3_k127_256100_9
efflux pump
K18138
-
-
0.0
1893.0
PJS3_k127_256100_90
Acts as a magnesium transporter
-
-
-
5.516e-289
894.0
PJS3_k127_256100_91
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
7.082e-288
885.0
PJS3_k127_256100_92
Acyltransferase ws dgat mgat
K00635
-
2.3.1.20
9.344e-288
885.0
PJS3_k127_256100_93
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
5.539e-280
863.0
PJS3_k127_256100_94
Histidine kinase
K07636
-
2.7.13.3
7.023e-279
858.0
PJS3_k127_256100_95
acetamidase formamidase
K01455
-
3.5.1.49
8.389e-279
856.0
PJS3_k127_256100_96
protein conserved in bacteria
K09859
-
-
2.194e-278
857.0
PJS3_k127_256100_97
O-acetylhomoserine
K01740
-
2.5.1.49
5.748e-278
855.0
PJS3_k127_256100_98
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01895
-
6.2.1.1
0.0
1324.0
PJS3_k127_3654974_100
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.0000000000000000000000000000000000000000004336
157.0
PJS3_k127_3654974_124
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.00000000000000000000000002092
109.0
PJS3_k127_3654974_13
receptor
K02014
-
-
0.0
1182.0
PJS3_k127_3654974_132
-
-
-
-
0.000000000000000001553
91.0
PJS3_k127_3654974_134
protein conserved in bacteria
K09937
-
-
0.00000000001147
67.0
PJS3_k127_3654974_14
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1165.0
PJS3_k127_3654974_15
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1144.0
PJS3_k127_3654974_16
Tetratricopeptide repeat
-
-
-
0.0
1135.0
PJS3_k127_3654974_17
ABC transporter ATP-binding protein
-
-
-
0.0
1110.0
PJS3_k127_3654974_18
Chemotaxis sensory transducer family protein
-
-
-
0.0
1052.0
PJS3_k127_3654974_19
flavoprotein involved in K transport
-
-
-
1.366e-319
979.0
PJS3_k127_3654974_2
Animal haem peroxidase
-
-
-
0.0
1866.0
PJS3_k127_3654974_20
Tetratricopeptide repeat
-
-
-
3.207e-305
946.0
PJS3_k127_3654974_21
-
-
-
-
1.921e-301
930.0
PJS3_k127_3654974_22
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
1.029e-299
929.0
PJS3_k127_3654974_23
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
4.311e-295
908.0
PJS3_k127_3654974_24
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
2.156e-286
884.0
PJS3_k127_3654974_25
amine dehydrogenase activity
-
-
-
8.819e-286
880.0
PJS3_k127_3654974_26
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00836
-
2.6.1.76
8.962e-284
877.0
PJS3_k127_3654974_27
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
9.617e-272
836.0
PJS3_k127_3654974_28
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
1.347e-260
805.0
PJS3_k127_3654974_29
GGDEF domain
-
-
-
2.724e-260
803.0
PJS3_k127_3654974_3
COG2909 ATP-dependent transcriptional regulator
-
-
-
0.0
1641.0
PJS3_k127_3654974_30
diguanylate cyclase
-
-
-
7.207e-255
788.0
PJS3_k127_3654974_31
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.893e-250
774.0
PJS3_k127_3654974_32
Protein of unknown function (DUF3570)
-
-
-
7.75e-238
738.0
PJS3_k127_3654974_33
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K14652
-
3.5.4.25,4.1.99.12
3.626e-231
717.0
PJS3_k127_3654974_34
( 3 oxidation state) methyltransferase
K07755
-
2.1.1.137
7.167e-228
707.0
PJS3_k127_3654974_35
Gram-negative porin
-
-
-
1.214e-227
706.0
PJS3_k127_3654974_36
-
-
-
-
3.077e-224
699.0
PJS3_k127_3654974_37
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
3.735e-220
689.0
PJS3_k127_3654974_38
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K11752
-
1.1.1.193,3.5.4.26
1.291e-217
681.0
PJS3_k127_3654974_39
C4-dicarboxylate ABC transporter
-
-
-
8.665e-215
668.0
PJS3_k127_3654974_4
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0
1579.0
PJS3_k127_3654974_40
Converts GTP to 7,8-dihydroneopterin triphosphate
K09007
-
3.5.4.16
1.712e-208
648.0
PJS3_k127_3654974_41
transcriptional regulator
-
-
-
2.815e-203
633.0
PJS3_k127_3654974_42
Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Uncharacterized protein conserved in bacteria (DUF2218)
K09956
-
-
0.000000000000000000000000000000001079
132.0
PJS3_k127_4022960_179
luxR family
-
-
-
0.00000000000000000000000000000001295
140.0
PJS3_k127_4022960_18
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
0.0
1109.0
PJS3_k127_4022960_184
-
-
-
-
0.000000000000000000000000522
112.0
PJS3_k127_4022960_185
Belongs to the 'phage' integrase family
-
-
-
0.000000000000000000000001326
103.0
PJS3_k127_4022960_187
Protein conserved in bacteria
-
-
-
0.00000000000000000000001273
103.0
PJS3_k127_4022960_19
Peptidase S8 and S53, subtilisin, kexin, sedolisin
K14645
-
-
0.0
1109.0
PJS3_k127_4022960_191
-
-
-
-
0.000000000000000000007216
100.0
PJS3_k127_4022960_193
helix_turn_helix multiple antibiotic resistance protein
-
-
-
0.00000000000000000138
91.0
PJS3_k127_4022960_195
-
-
-
-
0.000000000000007019
87.0
PJS3_k127_4022960_196
-
-
-
-
0.0000000000002478
73.0
PJS3_k127_4022960_198
helix_turn_helix, Lux Regulon
-
-
-
0.0000000004608
65.0
PJS3_k127_4022960_2
efflux pump
K19585
-
-
0.0
1903.0
PJS3_k127_4022960_20
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1075.0
PJS3_k127_4022960_200
acetyltransferases and hydrolases with the alpha beta hydrolase fold
-
-
-
0.000000004608
69.0
PJS3_k127_4022960_201
-
-
-
-
0.00000005215
58.0
PJS3_k127_4022960_203
Belongs to the glutamate synthase family
-
-
-
0.0000003954
53.0
PJS3_k127_4022960_205
Antitoxin component of a toxin-antitoxin (TA) module
-
-
-
0.000002317
53.0
PJS3_k127_4022960_206
ParE toxin of type II toxin-antitoxin system, parDE
-
-
-
0.000002458
54.0
PJS3_k127_4022960_207
Ankyrin repeat
-
-
-
0.00004969
53.0
PJS3_k127_4022960_208
-
-
-
-
0.00005967
55.0
PJS3_k127_4022960_21
alkyl hydroperoxide reductase
K03387
-
-
0.0
1049.0
PJS3_k127_4022960_22
protein related to deoxyribodipyrimidine photolyase
K06876
-
-
0.0
1042.0
PJS3_k127_4022960_23
May be involved in recombinational repair of damaged DNA
K03631
-
-
0.0
1039.0
PJS3_k127_4022960_24
flavoprotein involved in K transport
-
-
-
0.0
1024.0
PJS3_k127_4022960_25
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis
K03182
-
4.1.1.98
0.0
1012.0
PJS3_k127_4022960_26
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K01457
-
3.5.1.54
0.0
1010.0
PJS3_k127_4022960_27
Flavin-binding monooxygenase-like
-
-
-
0.0
1004.0
PJS3_k127_4022960_28
Alkane 1-monooxygenase
K00496
-
1.14.15.3
7e-323
987.0
PJS3_k127_4022960_29
flavoprotein involved in K transport
-
-
-
1.581e-314
968.0
PJS3_k127_4022960_3
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1592.0
PJS3_k127_4022960_30
Belongs to the GppA Ppx family
K01524
-
3.6.1.11,3.6.1.40
5.455e-314
964.0
PJS3_k127_4022960_31
Belongs to the amidase family
K01426
-
3.5.1.4
7.797e-312
957.0
PJS3_k127_4022960_32
flavoprotein involved in K transport
-
-
-
6.514e-311
958.0
PJS3_k127_4022960_33
Participates in both transcription termination and antitermination
K02600
-
-
2.177e-308
947.0
PJS3_k127_4022960_34
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.354e-277
856.0
PJS3_k127_4022960_39
COG0277 FAD FMN-containing dehydrogenases
-
-
-
2.75e-276
852.0
PJS3_k127_4022960_4
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1575.0
PJS3_k127_4022960_40
alpha beta
-
-
-
1.298e-270
833.0
PJS3_k127_4022960_41
branched-chain amino acid
K11959
-
-
2.06e-268
830.0
PJS3_k127_4022960_42
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
5.219e-268
826.0
PJS3_k127_4022960_43
Belongs to the thiolase family
K00626,K00632
-
2.3.1.16,2.3.1.9
1.944e-267
827.0
PJS3_k127_4022960_44
transferase
K02527
-
2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15
1.616e-265
822.0
PJS3_k127_4022960_45
amino acid aldolase or racemase
-
-
-
2.766e-265
818.0
PJS3_k127_4022960_46
Saccharopine dehydrogenase NADP binding domain
-
-
-
1.166e-259
802.0
PJS3_k127_4022960_47
COG1538 Outer membrane protein
K12340
-
-
7.975e-258
799.0
PJS3_k127_4022960_48
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Belongs to the binding-protein-dependent transport system permease family
K11960
-
-
1.301e-252
790.0
PJS3_k127_4022960_53
META domain
K09914
-
-
1.081e-247
769.0
PJS3_k127_4022960_54
Catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
K00574
-
2.1.1.79
7.05e-246
760.0
PJS3_k127_4022960_55
carbamoyl-phosphate synthetase glutamine chain
K01956
-
6.3.5.5
3.829e-244
757.0
PJS3_k127_4022960_56
carnitine dehydratase
-
-
-
5.531e-242
750.0
PJS3_k127_4022960_57
Pfam Adenylate and Guanylate cyclase catalytic domain
-
-
-
1.185e-233
727.0
PJS3_k127_4022960_58
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
1.21e-230
715.0
PJS3_k127_4022960_59
Belongs to the binding-protein-dependent transport system permease family
K11961
-
-
4.818e-230
715.0
PJS3_k127_4022960_6
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1457.0
PJS3_k127_4022960_60
Arabinose-binding domain of AraC transcription regulator, N-term
-
-
-
3.708e-228
709.0
PJS3_k127_4022960_61
Phytase
K01083
-
3.1.3.8
9.075e-226
715.0
PJS3_k127_4022960_62
helix_turn_helix, Lux Regulon
-
-
-
1.255e-215
673.0
PJS3_k127_4022960_63
-
-
-
-
1.511e-215
674.0
PJS3_k127_4022960_64
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01782
-
1.1.1.35,4.2.1.17,5.1.2.3
0.0
1379.0
PJS3_k127_4022960_80
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
2.5e-322
987.0
PJS3_k127_4092619_12
COG0477 Permeases of the major facilitator superfamily
K08167
-
-
2.038e-303
935.0
PJS3_k127_4092619_13
Belongs to the DEAD box helicase family
K05591
-
3.6.4.13
8.558e-288
890.0
PJS3_k127_4092619_14
alanine symporter
K03310
-
-
9.501e-276
859.0
PJS3_k127_4092619_15
PelD GGDEF domain
K21009
-
-
3.178e-273
843.0
PJS3_k127_4092619_16
membrane
K21012
-
-
8.849e-271
836.0
PJS3_k127_4092619_17
fatty acid desaturase
K00508
-
1.14.19.3
4.067e-270
832.0
PJS3_k127_4092619_18
Cobalamin synthesis protein P47K
-
-
-
5.789e-257
794.0
PJS3_k127_4092619_19
Sodium:sulfate symporter transmembrane region
K14445
-
-
1.125e-252
783.0
PJS3_k127_4092619_2
Glycoside-hydrolase family GH114
K21006
-
-
0.0
1638.0
PJS3_k127_4092619_20
extracellular ligand-binding receptor
K01999
-
-
4.8e-251
777.0
PJS3_k127_4092619_21
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
7.465e-249
771.0
PJS3_k127_4092619_22
COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
-
-
-
2.735e-248
767.0
PJS3_k127_4092619_23
ABC-type antimicrobial peptide transport system, permease component
K02004
-
-
2.22e-245
760.0
PJS3_k127_4092619_24
Zn-dependent protease
-
-
-
4.691e-241
749.0
PJS3_k127_4092619_25
enoyl-CoA hydratase
-
-
-
2.191e-236
735.0
PJS3_k127_4092619_26
COG0451 Nucleoside-diphosphate-sugar epimerases
-
-
-
1.886e-226
702.0
PJS3_k127_4092619_27
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K02836
-
-
1.728e-219
683.0
PJS3_k127_4092619_28
Belongs to the binding-protein-dependent transport system permease family
-
-
-
4.386e-218
678.0
PJS3_k127_4092619_29
Protein of unknown function (DUF3080)
-
-
-
1.827e-208
651.0
PJS3_k127_4092619_3
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K00108
-
1.1.99.1
0.0
1081.0
PJS3_k127_4092619_80
Tetratricopeptide repeat
K21010
-
-
0.00000000000000000000000000000000000000000008275
173.0
PJS3_k127_4092619_82
protein conserved in bacteria
K09984
-
-
0.000000000000000000000000000000000000001729
150.0
PJS3_k127_4092619_83
Belongs to the RelE toxin family
K19092
-
-
0.00000000000000000000000000000157
124.0
PJS3_k127_4092619_84
Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
ATPase components of ABC transporters with duplicated ATPase domains
-
-
-
0.0
1060.0
PJS3_k127_4092619_90
Zn-finger domain associated with topoisomerase type I
-
-
-
0.0000003612
55.0
PJS3_k127_4092619_91
COG1943 Transposase and inactivated derivatives
-
-
-
0.00004721
48.0
PJS3_k127_4095209_0
TIGRFAM Amino acid adenylation
-
-
-
0.0
3795.0
PJS3_k127_4095209_1
Non-ribosomal peptide synthetase modules and related
-
-
-
0.0
2852.0
PJS3_k127_4095209_10
Cyclic peptide transporter
K06159,K06160
-
-
2.917e-284
881.0
PJS3_k127_4095209_12
L-lysine 6-monooxygenase (NADPH-requiring)
K10531
-
1.14.13.195,1.14.13.196
4.831e-255
789.0
PJS3_k127_4095209_13
Belongs to the GSP D family
K02280
-
-
7.175e-238
743.0
PJS3_k127_4095209_14
Phospholipase
K01058
-
3.1.1.32,3.1.1.4
2.516e-232
720.0
PJS3_k127_4095209_15
COG4962 Flp pilus assembly protein, ATPase CpaF
K02283
-
-
1.342e-226
708.0
PJS3_k127_4095209_16
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.0000000000000000000000000000000008951
130.0
PJS3_k127_4095209_36
MbtH-like protein
K05375
-
-
0.000000000000000000000000000000002764
129.0
PJS3_k127_4095209_37
Belongs to the UPF0434 family
K09791
-
-
0.00000000000000000000000000000005466
126.0
PJS3_k127_4095209_38
Type IV leader peptidase family
K02278
-
3.4.23.43
0.00000000000000000000002307
106.0
PJS3_k127_4095209_39
Flp/Fap pilin component
-
-
-
0.00000000003363
68.0
PJS3_k127_4095209_4
TonB dependent receptor
K02014
-
-
0.0
1249.0
PJS3_k127_4095209_40
TadE-like protein
-
-
-
0.00000000003407
70.0
PJS3_k127_4095209_41
phosphatase
-
-
-
0.00008235
46.0
PJS3_k127_4095209_5
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0
1226.0
PJS3_k127_4095209_6
acyl-CoA dehydrogenase
-
-
-
0.0
1211.0
PJS3_k127_4095209_7
acyl-CoA dehydrogenase
-
-
-
0.0
1202.0
PJS3_k127_4095209_8
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1127.0
PJS3_k127_4095209_9
identical protein binding
-
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
5.2e-289
891.0
PJS3_k127_4362495_0
regulator of chromosome condensation, RCC1
-
-
-
0.0
6895.0
PJS3_k127_4362495_1
signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
-
-
-
0.0
1802.0
PJS3_k127_4362495_10
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K03500
-
2.1.1.176
2.823e-284
874.0
PJS3_k127_4362495_11
probably responsible for the translocation of the substrate across the membrane
K02037
-
-
5.266e-274
845.0
PJS3_k127_4362495_12
TRAP-type mannitol chloroaromatic compound transport system, large permease component
-
-
-
4.582e-270
837.0
PJS3_k127_4362495_13
Phosphate transport system permease
K02038
-
-
1.417e-254
788.0
PJS3_k127_4362495_14
Alpha beta hydrolase
-
-
-
2.185e-251
779.0
PJS3_k127_4362495_15
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.29e-250
773.0
PJS3_k127_4362495_16
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K01589
-
6.3.4.18
1.432e-237
735.0
PJS3_k127_4362495_2
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
K03657
-
3.6.4.12
0.0
1442.0
PJS3_k127_4362495_20
FAD binding domain
-
-
-
1.367e-230
717.0
PJS3_k127_4362495_21
Phosphate ABC transporter substrate-binding protein
K02040
-
-
4.693e-223
692.0
PJS3_k127_4362495_22
protein containing LysM domain
-
-
-
2.004e-221
693.0
PJS3_k127_4362495_23
Histidine kinase-like ATPases
-
-
-
6.734e-220
707.0
PJS3_k127_4362495_24
twitching motility protein
K02669
-
-
1.041e-216
673.0
PJS3_k127_4362495_25
Rossmann fold nucleotide-binding protein involved in DNA uptake
K04096
-
-
5.213e-210
655.0
PJS3_k127_4362495_26
Alanine racemase, N-terminal domain
-
-
-
3.757e-209
653.0
PJS3_k127_4362495_27
COG0798 Arsenite efflux pump ACR3 and related permeases
K03325
-
-
3.451e-206
643.0
PJS3_k127_4362495_28
Domain of unknown function (DUF1611_N) Rossmann-like domain
-
-
-
2.485e-204
645.0
PJS3_k127_4362495_29
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1400.0
PJS3_k127_4362495_30
protein conserved in bacteria
-
-
-
1.489e-201
630.0
PJS3_k127_4362495_31
-
-
-
-
8.807e-200
624.0
PJS3_k127_4362495_32
Catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA
K01640
-
4.1.3.4
3.333e-194
607.0
PJS3_k127_4362495_33
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
found to be peripherally associated with the inner membrane in Escherichia coli
K03499
-
-
5.159e-295
906.0
PJS3_k127_4362495_91
nucleic-acid-binding protein containing a Zn-ribbon domain
K07070
-
-
0.000000000000000000000000000000001013
131.0
PJS3_k127_4362495_92
-
-
-
-
0.0000000000000000000000000000001615
129.0
PJS3_k127_4362495_93
Belongs to the SlyX family
K03745
-
-
0.0000000000000000000000000000004034
126.0
PJS3_k127_4362495_96
-
-
-
-
0.000000001835
61.0
PJS3_k127_4362495_98
-
-
-
-
0.0002171
48.0
PJS3_k127_4369319_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
2270.0
PJS3_k127_4369319_1
accessory protein
K06959
-
-
0.0
1492.0
PJS3_k127_4369319_10
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
2.294e-303
933.0
PJS3_k127_4369319_100
-
-
-
-
0.000000000000008306
76.0
PJS3_k127_4369319_102
Belongs to the UPF0337 (CsbD) family
-
-
-
0.0000000002646
67.0
PJS3_k127_4369319_103
Immunity protein 26
-
-
-
0.000000002
64.0
PJS3_k127_4369319_104
Transposase
K07483
-
-
0.000001771
49.0
PJS3_k127_4369319_105
Protein of unknown function (DUF3592)
-
-
-
0.000009926
53.0
PJS3_k127_4369319_106
TfoX N-terminal domain
-
-
-
0.00003375
50.0
PJS3_k127_4369319_11
Thiol oxidoreductase
-
-
-
4.71e-297
913.0
PJS3_k127_4369319_12
NADH dehydrogenase
K03885
-
1.6.99.3
2.375e-281
867.0
PJS3_k127_4369319_13
Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
-
-
-
6.788e-278
856.0
PJS3_k127_4369319_14
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
K00833
-
2.6.1.62
6.511e-275
847.0
PJS3_k127_4369319_15
Histidine kinase
K07638
-
2.7.13.3
2.197e-269
831.0
PJS3_k127_4369319_16
Imelysin
K07231
-
-
2.821e-249
773.0
PJS3_k127_4369319_17
Membrane-bound lytic murein transglycosylase B
K08305
-
-
1.97e-243
754.0
PJS3_k127_4369319_18
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626,K00632
-
2.3.1.16,2.3.1.9
3.264e-240
744.0
PJS3_k127_4369319_19
Na H antiporter NhaD and related arsenite
-
-
-
5.995e-240
744.0
PJS3_k127_4369319_2
Belongs to the BCCT transporter (TC 2.A.15) family
K02168
-
-
0.0
1321.0
PJS3_k127_4369319_20
COG0845 Membrane-fusion protein
-
-
-
4.186e-237
739.0
PJS3_k127_4369319_21
COG2133 Glucose sorbosone dehydrogenases
K21430
-
-
1.249e-235
730.0
PJS3_k127_4369319_22
protein conserved in bacteria
K09947
-
-
7.899e-229
710.0
PJS3_k127_4369319_23
Uncharacterized protein conserved in bacteria (DUF2219)
-
-
-
3.604e-221
692.0
PJS3_k127_4369319_24
COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes
K06132
-
-
8.78e-215
680.0
PJS3_k127_4369319_25
HupE / UreJ protein
-
-
-
3.48e-214
668.0
PJS3_k127_4369319_26
COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
K00375
-
-
3.41e-213
671.0
PJS3_k127_4369319_27
Belongs to the sigma-70 factor family
K03088
-
-
2.185e-201
633.0
PJS3_k127_4369319_28
Deacetylases, including yeast histone deacetylase and acetoin utilization protein
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
metal-dependent hydrolase with the TIM-barrel fold
-
-
-
0.000000000000000000000000000003082
121.0
PJS3_k127_4369319_95
-
-
-
-
0.0000000000000000000000000008058
117.0
PJS3_k127_4369319_96
Domain of unknown function (DUF4398)
-
-
-
0.000000000000000000000001426
108.0
PJS3_k127_4369319_98
COG4568 Transcriptional antiterminator
K19000
-
-
0.000000000000000005395
88.0
PJS3_k127_4369319_99
Protein of unknown function (DUF3185)
-
-
-
0.00000000000000006162
85.0
PJS3_k127_4411826_0
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1866.0
PJS3_k127_4411826_1
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1834.0
PJS3_k127_4411826_10
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
6.382e-314
966.0
PJS3_k127_4411826_100
Type II transport protein GspH
K08084
-
-
0.00000002714
63.0
PJS3_k127_4411826_11
Adenylyl- / guanylyl cyclase, catalytic domain
K01768
-
4.6.1.1
1.367e-302
930.0
PJS3_k127_4411826_12
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.236e-289
891.0
PJS3_k127_4411826_13
unusual protein kinase
-
-
-
2.278e-278
857.0
PJS3_k127_4411826_14
Major facilitator superfamily
-
-
-
5.306e-269
831.0
PJS3_k127_4411826_15
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
K02667
-
-
1.834e-266
824.0
PJS3_k127_4411826_16
COG3552 Protein containing von Willebrand factor type A (vWA) domain
K07161
-
-
3.805e-263
813.0
PJS3_k127_4411826_17
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
1.724e-248
769.0
PJS3_k127_4411826_18
glycerophosphoryl diester phosphodiesterase
K01126
-
3.1.4.46
3.177e-246
766.0
PJS3_k127_4411826_19
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K00931
-
2.7.2.11
2.292e-230
715.0
PJS3_k127_4411826_2
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
9.942e-214
664.0
PJS3_k127_4411826_22
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03040
-
2.7.7.6
8.294e-212
659.0
PJS3_k127_4411826_23
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
2.818e-198
620.0
PJS3_k127_4411826_29
ATPase, AAA
-
-
-
4.614e-197
615.0
PJS3_k127_4411826_3
Histidine kinase
-
-
-
0.0
1530.0
PJS3_k127_4411826_30
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COG2303 Choline dehydrogenase and related flavoproteins
-
-
-
0.0
1296.0
PJS3_k127_4411826_50
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
Belongs to the universal ribosomal protein uL29 family
K02904
-
-
0.000000000000000000000000002303
111.0
PJS3_k127_4411826_92
Type II transport protein GspH
K08084
-
-
0.00000000000000000000004414
105.0
PJS3_k127_4411826_93
Prokaryotic N-terminal methylation motif
-
-
-
0.0000000000000000000116
98.0
PJS3_k127_4411826_94
Type IV pilus assembly protein PilX C-term
K02673
-
-
0.00000000000000000004595
97.0
PJS3_k127_4411826_96
Type IV minor pilin ComP, DNA uptake sequence receptor
K02655
-
-
0.000000000000000002803
91.0
PJS3_k127_4411826_97
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000000000003115
83.0
PJS3_k127_4411826_98
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.0000000000000006062
78.0
PJS3_k127_4411826_99
-
K06950
-
-
0.00000001202
59.0
PJS3_k127_4519829_0
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0
1168.0
PJS3_k127_4519829_1
Catalyzes the oxidation of L-aspartate to iminoaspartate
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
K11105
-
-
0.0
1046.0
PJS3_k127_4561092_12
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.0
1010.0
PJS3_k127_4561092_13
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
-
-
-
4.796e-312
961.0
PJS3_k127_4561092_14
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
8.723e-298
914.0
PJS3_k127_4561092_15
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
2.803e-286
880.0
PJS3_k127_4561092_16
COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes
K06132
-
-
2.041e-284
876.0
PJS3_k127_4561092_17
catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP
K00647
-
2.3.1.41
2.345e-260
803.0
PJS3_k127_4561092_18
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K00925
-
2.7.2.1
1.028e-246
766.0
PJS3_k127_4561092_19
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K07305,K12267
-
1.8.4.11,1.8.4.12
6.198e-231
720.0
PJS3_k127_4561092_2
belongs to the CobB CobQ family
K13788
-
2.3.1.8
0.0
1347.0
PJS3_k127_4561092_20
Na H antiporter
-
-
-
6.639e-219
685.0
PJS3_k127_4561092_21
NADPH quinone reductase and related Zn-dependent
K00344
-
1.6.5.5
5.05e-200
624.0
PJS3_k127_4561092_22
it plays a direct role in the translocation of protons across the membrane
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.00000000000000000000000000000000008487
134.0
PJS3_k127_4561092_49
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes
K06132
-
-
0.00000839
48.0
PJS3_k127_4561092_53
response to abiotic stimulus
-
-
-
0.0001034
52.0
PJS3_k127_4561092_6
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
K03495
-
-
0.0
1254.0
PJS3_k127_4561092_7
COG1960 Acyl-CoA dehydrogenases
-
-
-
0.0
1227.0
PJS3_k127_4561092_8
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
K05592
-
3.6.4.13
0.0
1062.0
PJS3_k127_4683931_3
COG0491 Zn-dependent hydrolases, including glyoxylases
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00282
-
1.4.4.2
2.992e-280
864.0
PJS3_k127_4683991_11
COG2067 Long-chain fatty acid transport protein
-
-
-
1.453e-254
790.0
PJS3_k127_4683991_12
hydroxylase
K18800
-
-
6.627e-251
777.0
PJS3_k127_4683991_13
COG2067 Long-chain fatty acid transport protein
-
-
-
8.025e-249
773.0
PJS3_k127_4683991_14
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
1.444e-246
762.0
PJS3_k127_4683991_15
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
9.344e-243
751.0
PJS3_k127_4683991_16
COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K03185
-
-
8.355e-234
730.0
PJS3_k127_4683991_17
catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
K01624
-
4.1.2.13
3.109e-232
719.0
PJS3_k127_4683991_18
The glycine cleavage system catalyzes the degradation of glycine
K00605
-
2.1.2.10
1.247e-230
717.0
PJS3_k127_4683991_19
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
0.0
1012.0
PJS3_k127_4683991_5
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K00281,K00283
-
1.4.4.2
3e-322
987.0
PJS3_k127_4683991_6
iron ABC transporter permease
K02011
-
-
1.697e-319
981.0
PJS3_k127_4683991_7
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K01251
-
3.3.1.1
2.46e-304
934.0
PJS3_k127_4683991_8
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
2.565e-295
906.0
PJS3_k127_4683991_9
long-chain fatty acid transporting porin activity
K06076
-
-
1.046e-280
865.0
PJS3_k127_4758316_0
DNA polymerase
K02337
-
2.7.7.7
0.0
2284.0
PJS3_k127_4758316_1
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
2276.0
PJS3_k127_4758316_10
COG1960 Acyl-CoA dehydrogenases
K06445
-
-
0.0
1624.0
PJS3_k127_4758316_101
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
K06176
-
5.4.99.27
1.747e-207
653.0
PJS3_k127_4758316_102
Cell wall formation
K00075
-
1.3.1.98
6.566e-207
646.0
PJS3_k127_4758316_103
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
K03621
-
2.3.1.15
2.803e-206
644.0
PJS3_k127_4758316_104
Esterase lipase
-
-
-
3.929e-206
643.0
PJS3_k127_4758316_105
Belongs to the cysteine synthase cystathionine beta- synthase family
K01738
-
2.5.1.47
6.266e-205
638.0
PJS3_k127_4758316_106
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
K00627,K09699
-
2.3.1.12,2.3.1.168
8.668e-204
640.0
PJS3_k127_4758316_107
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
K01207
-
3.2.1.52
3.343e-203
634.0
PJS3_k127_4758316_108
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K02536
-
2.3.1.191
6.135e-201
630.0
PJS3_k127_4758316_109
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
K01962
-
2.1.3.15,6.4.1.2
1.352e-200
625.0
PJS3_k127_4758316_11
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
0.0
1558.0
PJS3_k127_4758316_110
DNA polymerase III subunit delta
K02341
-
2.7.7.7
1.613e-199
625.0
PJS3_k127_4758316_111
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
2.581e-199
623.0
PJS3_k127_4758316_112
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K00858
-
2.7.1.23
6.553e-198
618.0
PJS3_k127_4758316_113
Uncharacterized protein conserved in bacteria (DUF2236)
-
-
-
1.06e-197
617.0
PJS3_k127_4758316_114
peptidase
K04773
-
-
2.604e-197
616.0
PJS3_k127_4758316_115
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
1.035e-196
616.0
PJS3_k127_4758316_116
Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K01711
-
4.2.1.47
2.32e-196
614.0
PJS3_k127_4758316_117
COG2148 Sugar transferases involved in lipopolysaccharide synthesis
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
COG0526 Thiol-disulfide isomerase and thioredoxins
-
-
-
0.000000000000000000000000000000000000005929
146.0
PJS3_k127_4758316_284
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.0000000000000000000000000000000000006513
140.0
PJS3_k127_4758316_285
Membrane protein involved in the export of O-antigen and teichoic acid
-
-
-
0.0000000000000000000000000000000001014
150.0
PJS3_k127_4758316_286
Protein of unknown function (DUF1656)
-
-
-
0.0000000000000000000000000000000008515
130.0
PJS3_k127_4758316_287
Protein of unknown function (DUF2971)
-
-
-
0.000000000000000000000000000000001177
142.0
PJS3_k127_4758316_288
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000000000001206
126.0
PJS3_k127_4758316_289
Protein conserved in bacteria
-
-
-
0.0000000000000000000000000000000212
131.0
PJS3_k127_4758316_29
Electron transfer flavoprotein-ubiquinone oxidoreductase
K00311
-
1.5.5.1
0.0
1158.0
PJS3_k127_4758316_291
Methyltransferase domain
-
-
-
0.0000000000000000000000000000002098
132.0
PJS3_k127_4758316_292
Family of unknown function (DUF695)
-
-
-
0.0000000000000000000000000000006905
127.0
PJS3_k127_4758316_294
Chaperone
-
-
-
0.0000000000000000000000000002289
123.0
PJS3_k127_4758316_295
-
-
-
-
0.0000000000000000000000001542
107.0
PJS3_k127_4758316_296
Glycosyltransferase Family 4
-
-
-
0.0000000000000000000000003226
119.0
PJS3_k127_4758316_298
FAD dependent oxidoreductase
-
-
-
0.000000000000000000001167
96.0
PJS3_k127_4758316_3
Tetratricopeptide repeat
-
-
-
0.0
1868.0
PJS3_k127_4758316_30
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K15461
-
2.1.1.61
0.0
1157.0
PJS3_k127_4758316_300
-
-
-
-
0.000000000000004415
75.0
PJS3_k127_4758316_301
-
-
-
-
0.0000000000006961
72.0
PJS3_k127_4758316_304
-
-
-
-
0.000000002683
65.0
PJS3_k127_4758316_306
-
-
-
-
0.00000002397
65.0
PJS3_k127_4758316_307
-
-
-
-
0.00000003348
63.0
PJS3_k127_4758316_31
Pfam:DUF1446
-
-
-
0.0
1145.0
PJS3_k127_4758316_311
COG2148 Sugar transferases involved in lipopolysaccharide synthesis
K03606,K21303
-
2.7.8.40
0.0000008322
52.0
PJS3_k127_4758316_313
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes)
K03812
-
-
0.00000987
48.0
PJS3_k127_4758316_314
Belongs to the glutamate synthase family
-
-
-
0.00001749
48.0
PJS3_k127_4758316_32
Bacterial Ig-like domain
-
-
-
0.0
1135.0
PJS3_k127_4758316_33
COG1073 Hydrolases of the alpha beta superfamily
-
-
-
0.0
1116.0
PJS3_k127_4758316_34
Serine Threonine protein
-
-
-
0.0
1092.0
PJS3_k127_4758316_35
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
0.0
1086.0
PJS3_k127_4758316_36
Alpha beta hydrolase
-
-
-
0.0
1082.0
PJS3_k127_4758316_37
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1081.0
PJS3_k127_4758316_38
acetoacetyl-CoA
K01907
-
6.2.1.16
0.0
1081.0
PJS3_k127_4758316_39
COG2010 Cytochrome c, mono- and diheme variants
K07243
-
-
0.0
1076.0
PJS3_k127_4758316_4
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1803.0
PJS3_k127_4758316_40
choline dehydrogenase activity
-
-
-
0.0
1073.0
PJS3_k127_4758316_41
belongs to the aldehyde dehydrogenase family
K22445
-
1.2.99.10
0.0
1070.0
PJS3_k127_4758316_42
Acetyl-CoA carboxylase
K13778
-
6.4.1.5
0.0
1060.0
PJS3_k127_4758316_43
COG4775 Outer membrane protein protective antigen OMA87
-
-
-
0.0
1048.0
PJS3_k127_4758316_44
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
-
-
-
0.0
1041.0
PJS3_k127_4758316_45
Monooxygenase, flavin-binding family
-
-
-
0.0
1030.0
PJS3_k127_4758316_47
COG2303 Choline dehydrogenase and related flavoproteins
-
-
-
0.0
1011.0
PJS3_k127_4758316_48
Belongs to the glutamate synthase family
K22083
-
2.1.1.21
0.0
997.0
PJS3_k127_4758316_49
Protein of unknown function (DUF1329)
-
-
-
3.216e-311
954.0
PJS3_k127_4758316_5
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1779.0
PJS3_k127_4758316_50
Nitrate nitrite transporter
K02575
-
-
6.759e-306
939.0
PJS3_k127_4758316_51
Trypsin-like serine protease
-
-
-
7.016e-300
925.0
PJS3_k127_4758316_52
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
7.238e-297
914.0
PJS3_k127_4758316_53
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
4.838e-285
881.0
PJS3_k127_4758316_54
Transposase
-
-
-
6.571e-283
872.0
PJS3_k127_4758316_55
Ammonium transporter
K03320
-
-
9.259e-275
846.0
PJS3_k127_4758316_56
-
-
-
-
5.333e-274
844.0
PJS3_k127_4758316_57
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
K00351
-
1.6.5.8
1.307e-272
838.0
PJS3_k127_4758316_58
in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
K14260
-
2.6.1.2,2.6.1.66
1.266e-270
833.0
PJS3_k127_4758316_59
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
7.412e-268
825.0
PJS3_k127_4758316_6
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K00372
-
-
0.0
1778.0
PJS3_k127_4758316_60
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
6.082e-267
824.0
PJS3_k127_4758316_61
zinc metalloprotease
K11749
-
-
4.658e-266
822.0
PJS3_k127_4758316_62
protein conserved in bacteria
K09760
-
-
1.123e-262
812.0
PJS3_k127_4758316_63
COG2067 Long-chain fatty acid transport protein
-
-
-
6.222e-262
810.0
PJS3_k127_4758316_64
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
2.082e-260
803.0
PJS3_k127_4758316_65
Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate
K14267
-
2.6.1.17
5.624e-259
803.0
PJS3_k127_4758316_66
-
-
-
-
1.262e-258
799.0
PJS3_k127_4758316_67
Aminotransferase
K00812
-
2.6.1.1
6.4e-257
792.0
PJS3_k127_4758316_68
TrkA-N domain
-
-
-
3.858e-256
800.0
PJS3_k127_4758316_69
HI0933-like protein
K07007
-
-
9.059e-256
791.0
PJS3_k127_4758316_7
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
0.0
1748.0
PJS3_k127_4758316_70
COG0438 Glycosyltransferase
-
-
-
3.586e-252
779.0
PJS3_k127_4758316_71
Lipoprotein releasing system, transmembrane protein
K09808
-
-
7.191e-252
779.0
PJS3_k127_4758316_72
protein conserved in bacteria
-
-
-
2.477e-251
778.0
PJS3_k127_4758316_73
acyl-CoA dehydrogenase
K11731
-
-
1.555e-250
773.0
PJS3_k127_4758316_74
reductase
K00362
-
1.7.1.15
1.237e-249
773.0
PJS3_k127_4758316_75
Sulfotransferase family
-
-
-
1.881e-247
766.0
PJS3_k127_4758316_76
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
6.326e-243
755.0
PJS3_k127_4758316_77
esterase of the alpha-beta hydrolase superfamily
K07001
-
-
8.244e-242
749.0
PJS3_k127_4758316_78
phosphomannomutase
K15778
-
5.4.2.2,5.4.2.8
1.212e-239
747.0
PJS3_k127_4758316_79
FR47-like protein
-
-
-
4.816e-238
737.0
PJS3_k127_4758316_8
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K00362
-
1.7.1.15
0.0
1694.0
PJS3_k127_4758316_80
mechanosensitive ion channel
K16052
-
-
5.743e-238
737.0
PJS3_k127_4758316_81
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
1.193e-237
737.0
PJS3_k127_4758316_82
COG0520 Selenocysteine lyase
-
-
-
2.178e-237
735.0
PJS3_k127_4758316_83
COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
-
-
-
8.781e-232
718.0
PJS3_k127_4758316_84
exonuclease of the beta-lactamase fold involved in RNA processing
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
1.232e-228
709.0
PJS3_k127_4758316_87
alcohol dehydrogenase
-
-
-
9.878e-226
702.0
PJS3_k127_4758316_88
protein related to plant photosystem II stability
-
-
-
6.498e-224
697.0
PJS3_k127_4758316_89
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K00748
-
2.4.1.182
1.356e-223
697.0
PJS3_k127_4758316_9
Belongs to the GPAT DAPAT family
K00631
-
2.3.1.15
0.0
1636.0
PJS3_k127_4758316_90
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
7.205e-222
688.0
PJS3_k127_4758316_91
ATP-NAD kinase
-
-
-
1.151e-221
691.0
PJS3_k127_4758316_92
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
3.502e-216
674.0
PJS3_k127_4758316_93
FAD dependent oxidoreductase
K15736
-
-
4.326e-214
668.0
PJS3_k127_4758316_94
Belongs to the agmatine deiminase family
-
-
-
1.552e-213
668.0
PJS3_k127_4758316_95
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
K00912
-
2.7.1.130
4.207e-213
664.0
PJS3_k127_4758316_96
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
K00254
-
1.3.5.2
8.713e-210
653.0
PJS3_k127_4758316_97
COG1253 Hemolysins and related proteins containing CBS domains
-
-
-
1.14e-209
653.0
PJS3_k127_4758316_98
Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate
K03473
-
1.1.1.290
3.184e-209
654.0
PJS3_k127_4758316_99
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
K15257
-
-
1.083e-208
650.0
PJS3_k127_4765145_0
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
-
-
-
0.000000001008
69.0
PJS3_k127_4765145_124
-
-
-
-
0.00000007274
57.0
PJS3_k127_4765145_13
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
1.521e-287
887.0
PJS3_k127_4765145_14
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
-
-
-
4.814e-286
882.0
PJS3_k127_4765145_15
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.798e-277
854.0
PJS3_k127_4765145_16
Involved in the TonB-independent uptake of proteins
K03641
-
-
8.213e-277
852.0
PJS3_k127_4765145_17
NAD FAD-binding protein
K06954
-
-
4.122e-275
856.0
PJS3_k127_4765145_18
homoserine dehydrogenase
K00003
-
1.1.1.3
3.547e-274
844.0
PJS3_k127_4765145_19
Belongs to the peptidase S1C family
K04691,K04771,K04772
-
3.4.21.107
3.586e-273
845.0
PJS3_k127_4765145_2
DNA helicase
K03654
-
3.6.4.12
0.0
1389.0
PJS3_k127_4765145_20
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
3.485e-269
829.0
PJS3_k127_4765145_21
Beta-lactamase class C and other penicillin binding
COG2230 Cyclopropane fatty acid synthase and related methyltransferases
K00574
-
2.1.1.79
1.823e-260
806.0
PJS3_k127_4765145_26
Mg2 and Co2 transporter CorB
-
-
-
5.163e-260
803.0
PJS3_k127_4765145_27
DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K11927
-
3.6.4.13
7.331e-260
804.0
PJS3_k127_4765145_28
-
-
-
-
1.429e-259
799.0
PJS3_k127_4765145_29
Belongs to the sulfate adenylyltransferase family
K00958
-
2.7.7.4
2.069e-255
788.0
PJS3_k127_4765145_3
-
-
-
-
0.0
1224.0
PJS3_k127_4765145_30
-
-
-
-
7.423e-242
751.0
PJS3_k127_4765145_31
-
-
-
-
3.66e-241
747.0
PJS3_k127_4765145_32
Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K01733
-
4.2.3.1
5.096e-233
721.0
PJS3_k127_4765145_33
His Kinase A (phosphoacceptor) domain
K15011
-
2.7.13.3
9.406e-233
724.0
PJS3_k127_4765145_34
Chromate
K07240
-
-
1.369e-227
707.0
PJS3_k127_4765145_35
Deacylase
K06987
-
-
4.325e-227
705.0
PJS3_k127_4765145_36
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
3.079e-226
702.0
PJS3_k127_4765145_37
Serine Threonine protein kinase
-
-
-
1.972e-224
702.0
PJS3_k127_4765145_38
Domain of unknown function (DUF4062)
-
-
-
1.958e-218
679.0
PJS3_k127_4765145_39
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1092.0
PJS3_k127_4765145_80
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
K00265
-
1.4.1.13,1.4.1.14
0.0
2999.0
PJS3_k127_4772472_1
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1856.0
PJS3_k127_4772472_10
type II secretion system protein
K02454
-
-
0.0
1177.0
PJS3_k127_4772472_100
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
0.0
1057.0
PJS3_k127_4772472_150
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.0000000000000000000000000000002523
127.0
PJS3_k127_4772472_166
-
-
-
-
0.00000000000000000000000000000692
122.0
PJS3_k127_4772472_167
Uncharacterized protein conserved in bacteria (DUF2065)
highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues
K01915
-
6.3.1.2
1.241e-315
967.0
PJS3_k127_4772472_22
Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes
K07712
-
-
2.771e-309
948.0
PJS3_k127_4772472_23
argininosuccinate lyase
K01755
-
4.3.2.1
1.484e-303
932.0
PJS3_k127_4772472_24
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
1.519e-298
919.0
PJS3_k127_4772472_25
Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K03272
-
2.7.1.167,2.7.7.70
6.061e-298
916.0
PJS3_k127_4772472_26
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
1.609e-289
893.0
PJS3_k127_4772472_28
Na H antiporter
K03315
-
-
8.422e-289
890.0
PJS3_k127_4772472_29
2-hydroxychromene-2-carboxylate isomerase
-
-
-
1.012e-288
887.0
PJS3_k127_4772472_3
penicillin-binding protein
K05366
-
2.4.1.129,3.4.16.4
0.0
1602.0
PJS3_k127_4772472_30
7 transmembrane helices usually fused to an inactive transglutaminase
-
-
-
1.634e-285
882.0
PJS3_k127_4772472_31
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
8.534e-283
871.0
PJS3_k127_4772472_32
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
6.322e-282
867.0
PJS3_k127_4772472_33
Belongs to the acetyltransferase family. ArgA subfamily
K14682
-
2.3.1.1
1.745e-279
863.0
PJS3_k127_4772472_34
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
7.046e-273
839.0
PJS3_k127_4772472_35
Malate dehydrogenase
K00027,K00029
-
1.1.1.38,1.1.1.40
1.291e-272
839.0
PJS3_k127_4772472_36
paraquat-inducible protein A
K03808
-
-
4.377e-266
821.0
PJS3_k127_4772472_37
domain, Protein
K03112
-
-
5.275e-264
823.0
PJS3_k127_4772472_38
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
1.39e-263
817.0
PJS3_k127_4772472_39
phosphate transporter
K03306
-
-
1.57e-260
805.0
PJS3_k127_4772472_4
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.0
1409.0
PJS3_k127_4772472_40
Cytochrome c
-
-
-
2.489e-260
811.0
PJS3_k127_4772472_41
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.581e-257
796.0
PJS3_k127_4772472_42
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
4.258e-257
795.0
PJS3_k127_4772472_43
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
-
-
-
9.929e-244
754.0
PJS3_k127_4772472_48
COG3307 Lipid A core - O-antigen ligase and related enzymes
-
-
-
4.352e-242
749.0
PJS3_k127_4772472_49
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K02502
-
-
2.841e-240
744.0
PJS3_k127_4772472_5
protein involved in outer membrane biogenesis
K07289
-
-
0.0
1327.0
PJS3_k127_4772472_50
Histidine kinase
K07708
-
2.7.13.3
1.004e-228
710.0
PJS3_k127_4772472_51
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K18979
-
1.17.99.6
1.791e-228
713.0
PJS3_k127_4772472_52
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
4.386e-228
708.0
PJS3_k127_4772472_53
glycosylase
K03575
-
-
1.2e-225
703.0
PJS3_k127_4772472_54
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
K00652
-
2.3.1.47
8.894e-225
699.0
PJS3_k127_4772472_55
peptidase
-
-
-
4.499e-224
697.0
PJS3_k127_4772472_56
HflC and HflK could encode or regulate a protease
K04088
-
-
2.433e-223
696.0
PJS3_k127_4772472_57
Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K01775
-
5.1.1.1
7.37e-216
672.0
PJS3_k127_4772472_58
Pilus assembly protein
K02662
-
-
9.163e-215
668.0
PJS3_k127_4772472_59
alpha-L-glutamate ligase
-
-
-
4.813e-214
666.0
PJS3_k127_4772472_6
Calcineurin-like phosphoesterase
K14379
-
3.1.3.2
0.0
1318.0
PJS3_k127_4772472_60
heptosyltransferase
K02843
-
-
5.579e-214
666.0
PJS3_k127_4772472_61
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
K06949
-
3.1.3.100
1.001e-209
653.0
PJS3_k127_4772472_62
COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
signal transduction protein with a C-terminal ATPase domain
K08082
-
2.7.13.3
7.479e-201
628.0
PJS3_k127_4772472_66
HflC and HflK could regulate a protease
K04087
-
-
3.654e-199
624.0
PJS3_k127_4772472_67
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K00826
-
2.6.1.42
4.923e-199
621.0
PJS3_k127_4772472_68
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
2.342e-198
620.0
PJS3_k127_4772472_69
Belongs to the 'phage' integrase family. XerC subfamily
K03733
-
-
7.842e-195
608.0
PJS3_k127_4772472_7
Belongs to the IlvD Edd family
K01687
-
4.2.1.9
0.0
1221.0
PJS3_k127_4772472_70
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Sulfate permease and related transporters (MFS superfamily)
K03321
-
-
1.117e-297
917.0
PJS3_k127_4803723_102
cytochrome P450
-
-
-
1.141e-297
914.0
PJS3_k127_4803723_103
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K01703
-
4.2.1.33,4.2.1.35
1.509e-294
906.0
PJS3_k127_4803723_104
belongs to the aldehyde dehydrogenase family
K00128
-
1.2.1.3
2.852e-294
906.0
PJS3_k127_4803723_105
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
4.916e-294
905.0
PJS3_k127_4803723_106
E1-E2 ATPase
K01547
-
3.6.3.12
1.17e-292
912.0
PJS3_k127_4803723_107
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
5.059e-291
895.0
PJS3_k127_4803723_108
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
6.167e-290
891.0
PJS3_k127_4803723_109
Major facilitator superfamily
-
-
-
6.436e-290
893.0
PJS3_k127_4803723_11
COG0642 Signal transduction histidine kinase
-
-
-
0.0
1778.0
PJS3_k127_4803723_110
Alpha beta hydrolase superfamily
K01563
-
3.8.1.5
1.976e-289
891.0
PJS3_k127_4803723_111
MATE efflux family protein
K03327
-
-
8.045e-289
890.0
PJS3_k127_4803723_112
COG1283 Na phosphate symporter
K03324
-
-
5.16e-288
889.0
PJS3_k127_4803723_113
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K02302,K02303
-
1.3.1.76,2.1.1.107,4.99.1.4
2.209e-285
880.0
PJS3_k127_4803723_114
Uncharacterized protein conserved in bacteria (DUF2236)
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K00325
-
1.6.1.2
9.354e-279
859.0
PJS3_k127_4803723_119
Converts isocitrate to alpha ketoglutarate
K00031
-
1.1.1.42
1.318e-277
853.0
PJS3_k127_4803723_12
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K20455
-
4.2.1.117
0.0
1726.0
PJS3_k127_4803723_120
ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
1.398e-277
856.0
PJS3_k127_4803723_121
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
8.836e-275
848.0
PJS3_k127_4803723_122
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
3.371e-274
846.0
PJS3_k127_4803723_123
Predicted membrane protein (DUF2157)
-
-
-
2.022e-272
841.0
PJS3_k127_4803723_124
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K00383
-
1.8.1.7
4.133e-272
840.0
PJS3_k127_4803723_125
Ammonium transporter
K03320
-
-
3.286e-271
837.0
PJS3_k127_4803723_126
COG1960 Acyl-CoA dehydrogenases
-
-
-
9.952e-269
826.0
PJS3_k127_4803723_127
unusual protein kinase
-
-
-
1.003e-267
829.0
PJS3_k127_4803723_128
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
2.937e-267
822.0
PJS3_k127_4803723_129
membrane
K07058
-
-
9.833e-265
817.0
PJS3_k127_4803723_13
Belongs to the aconitase IPM isomerase family
K01682
-
4.2.1.3,4.2.1.99
0.0
1712.0
PJS3_k127_4803723_130
Domain of unknown function (DUF4350)
-
-
-
3.656e-264
816.0
PJS3_k127_4803723_131
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
4.948e-262
810.0
PJS3_k127_4803723_132
Alginate export
-
-
-
8.961e-261
805.0
PJS3_k127_4803723_133
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
4.011e-260
802.0
PJS3_k127_4803723_134
Binding-protein-dependent transport system inner membrane component
-
-
-
1.453e-259
804.0
PJS3_k127_4803723_135
unusual protein kinase
-
-
-
2.471e-259
800.0
PJS3_k127_4803723_136
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K22067
-
-
3.511e-259
799.0
PJS3_k127_4803723_137
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
1.948e-256
792.0
PJS3_k127_4803723_143
conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
-
-
-
3.497e-256
797.0
PJS3_k127_4803723_144
COG0515 Serine threonine protein kinase
-
-
-
2.013e-255
789.0
PJS3_k127_4803723_145
Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA
K00253
-
1.3.8.4
4.282e-254
785.0
PJS3_k127_4803723_146
DNA polymerase
K03502
-
-
4.397e-253
784.0
PJS3_k127_4803723_147
Protein conserved in bacteria
-
-
-
6.06e-253
782.0
PJS3_k127_4803723_148
COG0477 Permeases of the major facilitator superfamily
-
-
-
2.713e-252
781.0
PJS3_k127_4803723_149
acyl-CoA dehydrogenase
K00249
-
1.3.8.7
7.053e-252
778.0
PJS3_k127_4803723_15
Part of a membrane complex involved in electron transport
K03615
-
-
0.0
1640.0
PJS3_k127_4803723_150
Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
-
-
-
2.004e-251
779.0
PJS3_k127_4803723_151
-
-
-
-
2.062e-250
776.0
PJS3_k127_4803723_152
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K00324
-
1.6.1.2
6.54e-250
773.0
PJS3_k127_4803723_153
COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
K01999
-
-
1.954e-249
771.0
PJS3_k127_4803723_154
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
1.926e-248
767.0
PJS3_k127_4803723_155
membrane protein, required for spore maturation in B.subtilis
-
-
-
3.238e-248
768.0
PJS3_k127_4803723_156
Belongs to the citrate synthase family
K01659
-
2.3.3.5
2.788e-247
763.0
PJS3_k127_4803723_157
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
-
-
-
2.908e-246
767.0
PJS3_k127_4803723_158
protein conserved in bacteria
K09788
-
-
1.578e-245
759.0
PJS3_k127_4803723_159
P-aminobenzoate N-oxygenase AurF
-
-
-
2.02e-245
758.0
PJS3_k127_4803723_16
exporters of the RND superfamily
K07003
-
-
0.0
1629.0
PJS3_k127_4803723_160
Belongs to the thiolase family
K00626
-
2.3.1.9
4.057e-245
760.0
PJS3_k127_4803723_161
acyl-CoA dehydrogenase
K06446
-
-
6.982e-244
755.0
PJS3_k127_4803723_162
carnitine dehydratase
K01796
-
5.1.99.4
5.405e-243
751.0
PJS3_k127_4803723_163
COG3243 Poly(3-hydroxyalkanoate) synthetase
-
-
-
2.404e-242
750.0
PJS3_k127_4803723_164
Sensory box protein response regulator
-
-
-
1.621e-241
748.0
PJS3_k127_4803723_165
general secretion pathway protein
K02455
-
-
2.436e-241
748.0
PJS3_k127_4803723_166
Uncharacterized protein conserved in bacteria (DUF2236)
-
-
-
3.581e-240
744.0
PJS3_k127_4803723_167
Aminotransferase
-
-
-
6.834e-240
742.0
PJS3_k127_4803723_168
Belongs to the thiolase family
K00626
-
2.3.1.9
1.561e-239
744.0
PJS3_k127_4803723_169
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
2.349e-239
741.0
PJS3_k127_4803723_17
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
K01007
-
2.7.9.2
0.0
1577.0
PJS3_k127_4803723_170
Type VI secretion
K11896
-
-
1.381e-238
751.0
PJS3_k127_4803723_171
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
1.202e-237
735.0
PJS3_k127_4803723_172
COG0477 Permeases of the major facilitator superfamily
-
-
-
2.273e-237
737.0
PJS3_k127_4803723_173
Transcription factor
K18850
-
1.14.11.47
7.501e-236
732.0
PJS3_k127_4803723_174
differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
K00648,K16872
-
2.3.1.180,2.3.1.207
1.605e-235
730.0
PJS3_k127_4803723_175
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
3.679e-234
726.0
PJS3_k127_4803723_176
Catalyzes the sodium-dependent transport of glutamate
K03312
-
-
3.035e-233
725.0
PJS3_k127_4803723_177
Major facilitator superfamily
K07552
-
-
5.172e-233
724.0
PJS3_k127_4803723_178
COG0477 Permeases of the major facilitator superfamily
K05820
-
-
8.353e-231
718.0
PJS3_k127_4803723_179
COG1960 Acyl-CoA dehydrogenases
-
-
-
2.61e-230
715.0
PJS3_k127_4803723_18
Tfp pilus assembly protein
K08086
-
-
0.0
1531.0
PJS3_k127_4803723_180
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K02461
-
-
7.834e-230
714.0
PJS3_k127_4803723_181
acetoacetyl-CoA
K01907
-
6.2.1.16
2.447e-229
714.0
PJS3_k127_4803723_182
Belongs to the folylpolyglutamate synthase family
K11754
-
6.3.2.12,6.3.2.17
1.073e-228
711.0
PJS3_k127_4803723_183
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K03585
-
-
1.756e-228
711.0
PJS3_k127_4803723_184
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K06968
-
2.1.1.186
5.683e-228
707.0
PJS3_k127_4803723_185
Radical SAM
-
-
-
8.924e-228
709.0
PJS3_k127_4803723_186
Gluconolactonase
-
-
-
1.417e-227
711.0
PJS3_k127_4803723_187
catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
K03412
-
3.1.1.61,3.5.1.44
9.125e-227
705.0
PJS3_k127_4803723_188
COG0491 Zn-dependent hydrolases, including glyoxylases
-
-
-
2.614e-226
701.0
PJS3_k127_4803723_189
With YejAEF is involved in resistance to microcin C
K13894
-
-
4.763e-224
695.0
PJS3_k127_4803723_19
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1521.0
PJS3_k127_4803723_190
Phosphoribosylformylglycinamidine cyclo-ligase
K01933
-
6.3.3.1
4.811e-224
696.0
PJS3_k127_4803723_191
Aminoglycoside phosphotransferase
-
-
-
5.612e-224
694.0
PJS3_k127_4803723_192
ABC transporter permease
K13895
-
-
1.19e-221
688.0
PJS3_k127_4803723_193
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
K11391
-
2.1.1.174
2.16e-221
690.0
PJS3_k127_4803723_194
AraC family transcriptional regulator
-
-
-
1.21e-219
681.0
PJS3_k127_4803723_195
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
K03593
-
-
7.12e-217
679.0
PJS3_k127_4803723_20
Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K00549
-
2.1.1.14
0.0
1519.0
PJS3_k127_4803723_200
Part of a membrane complex involved in electron transport
K03614
-
-
4.737e-215
670.0
PJS3_k127_4803723_201
GGDEF domain
K21019
-
2.7.7.65
5.731e-215
670.0
PJS3_k127_4803723_202
acyl-CoA dehydrogenase
-
-
-
3.015e-214
668.0
PJS3_k127_4803723_203
Aldo Keto reductase
-
-
-
4.548e-214
666.0
PJS3_k127_4803723_204
Glycerol-3-phosphate dehydrogenase
K00057
-
1.1.1.94
5.018e-213
663.0
PJS3_k127_4803723_205
Preprotein translocase subunit SecA
-
-
-
5.322e-212
659.0
PJS3_k127_4803723_206
COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain
-
-
-
5.112e-211
663.0
PJS3_k127_4803723_207
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
1.316e-210
656.0
PJS3_k127_4803723_208
PFAM Prolipoprotein diacylglyceryl transferase
-
-
-
3.805e-210
656.0
PJS3_k127_4803723_209
Belongs to the binding-protein-dependent transport system permease family
K01998
-
-
6.106e-210
659.0
PJS3_k127_4803723_21
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Catalyzes the reversible oxidation of malate to oxaloacetate
K00024
-
1.1.1.37
2.448e-208
649.0
PJS3_k127_4803723_214
type VI secretion protein, VC_A0114 family
K11893
-
-
1.908e-207
653.0
PJS3_k127_4803723_215
glycosyl transferase family
-
-
-
2.519e-207
649.0
PJS3_k127_4803723_216
Belongs to the ompA family
K03286
-
-
1.317e-206
646.0
PJS3_k127_4803723_217
COG0451 Nucleoside-diphosphate-sugar epimerases
K00091
-
1.1.1.219
2.738e-206
643.0
PJS3_k127_4803723_218
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K08963
-
5.3.1.23
3.614e-206
643.0
PJS3_k127_4803723_219
ABC-type nitrate sulfonate bicarbonate transport system, permease component
K15577
-
-
4.116e-206
643.0
PJS3_k127_4803723_22
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1495.0
PJS3_k127_4803723_220
in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue
K07320
-
2.1.1.298
6.086e-197
617.0
PJS3_k127_4803723_239
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
K05539
-
-
8.723e-196
614.0
PJS3_k127_4803723_24
Domain of Unknown Function (DUF349)
-
-
-
0.0
1483.0
PJS3_k127_4803723_240
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01638
-
2.3.3.9
0.0
1425.0
PJS3_k127_4803723_330
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K07516
-
1.1.1.35
0.0
1358.0
PJS3_k127_4803723_360
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K02196
-
-
0.0000000000000000000000000006112
116.0
PJS3_k127_4803723_588
-
-
-
-
0.0000000000000000000000000756
108.0
PJS3_k127_4803723_589
Two component signalling adaptor domain
K03408
-
-
0.0000000000000000000000002575
111.0
PJS3_k127_4803723_59
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
-
-
-
0.0
1139.0
PJS3_k127_4803723_590
-
-
-
-
0.0000000000000000000003212
100.0
PJS3_k127_4803723_592
Cbb3-type cytochrome oxidase
K00407
-
-
0.0000000000000000000008467
94.0
PJS3_k127_4803723_593
Type VI secretion system
K11905
-
-
0.000000000000000000002743
101.0
PJS3_k127_4803723_594
Belongs to the acylphosphatase family
K01512
-
3.6.1.7
0.0000000000000000004063
91.0
PJS3_k127_4803723_597
protein conserved in bacteria
K09926
-
-
0.00000000000000002221
89.0
PJS3_k127_4803723_6
Bacterial Ig-like domain
-
-
-
0.0
2108.0
PJS3_k127_4803723_60
Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids
K00666
-
-
0.0
1131.0
PJS3_k127_4803723_613
-
-
-
-
0.0000002164
56.0
PJS3_k127_4803723_616
-
-
-
-
0.00000525
50.0
PJS3_k127_4803723_617
-
-
-
-
0.000009944
49.0
PJS3_k127_4803723_618
-
-
-
-
0.0000229
48.0
PJS3_k127_4803723_619
Cytochrome oxidase maturation protein
-
-
-
0.00002301
53.0
PJS3_k127_4803723_62
Sulfite reductase
K00381
-
1.8.1.2
0.0
1109.0
PJS3_k127_4803723_620
-
-
-
-
0.00002741
48.0
PJS3_k127_4803723_625
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.0002839
44.0
PJS3_k127_4803723_626
-
-
-
-
0.0003644
52.0
PJS3_k127_4803723_628
-
-
-
-
0.0008195
42.0
PJS3_k127_4803723_63
Long-chain fatty acid transport protein
-
-
-
0.0
1105.0
PJS3_k127_4803723_64
Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta
K01969
-
6.4.1.4
0.0
1071.0
PJS3_k127_4803723_65
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
0.0
1061.0
PJS3_k127_4803723_66
Carbon starvation protein
K06200
-
-
0.0
1059.0
PJS3_k127_4803723_67
ABC1 family protein, ubiquinone biosynthesis protein
K03688
-
-
0.0
1051.0
PJS3_k127_4803723_68
COG0277 FAD FMN-containing dehydrogenases
K00803
-
2.5.1.26
0.0
1047.0
PJS3_k127_4803723_69
Histidine kinase
-
-
-
0.0
1036.0
PJS3_k127_4803723_7
efflux pump
K18138
-
-
0.0
1987.0
PJS3_k127_4803723_70
Rhs element Vgr protein
K11904
-
-
0.0
1029.0
PJS3_k127_4803723_71
Osmosensitive K+ channel His kinase sensor domain
K07646
-
2.7.13.3
0.0
1020.0
PJS3_k127_4803723_72
Protein of unknown function (DUF1573)
-
-
-
0.0
1016.0
PJS3_k127_4803723_73
Carbohydrate kinase
K00854,K00862
-
2.7.1.17,2.7.1.215
0.0
1013.0
PJS3_k127_4803723_74
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
0.0
1011.0
PJS3_k127_4803723_75
BFD-like [2Fe-2S] binding domain
K00362
-
1.7.1.15
0.0
1011.0
PJS3_k127_4803723_76
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K00764
-
2.4.2.14
0.0
1007.0
PJS3_k127_4803723_77
COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)
K08307
-
-
0.0
1000.0
PJS3_k127_4803723_78
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
0.0
996.0
PJS3_k127_4803723_79
Catalyzes the reversible hydration of fumarate to (S)- malate
K01676
-
4.2.1.2
3e-323
996.0
PJS3_k127_4803723_8
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1928.0
PJS3_k127_4803723_80
Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K03314
-
-
3.6e-322
989.0
PJS3_k127_4803723_81
esterase of the alpha-beta hydrolase superfamily
K07001
-
-
2.446e-321
985.0
PJS3_k127_4803723_82
COG2368 Aromatic ring hydroxylase
-
-
-
1.609e-317
975.0
PJS3_k127_4803723_83
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
6.469e-317
971.0
PJS3_k127_4803723_84
Carboxylesterase type B
K03929
-
-
1.832e-316
973.0
PJS3_k127_4803723_85
Belongs to the ABC transporter superfamily
K13896
-
-
1.498e-315
969.0
PJS3_k127_4803723_86
type VI secretion protein
K11900
-
-
3.082e-315
968.0
PJS3_k127_4803723_87
COG3540 Phosphodiesterase alkaline phosphatase D
K01113
-
3.1.3.1
1.799e-314
962.0
PJS3_k127_4803723_88
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454
-
-
2.475e-314
964.0
PJS3_k127_4803723_89
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
-
-
-
3.568e-201
628.0
PJS3_k127_5646661_103
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COG1233 Phytoene dehydrogenase and related proteins
K09516
-
1.3.99.23
0.0
1074.0
PJS3_k127_5646661_241
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K03586
-
-
0.0000000000000000000000000000000000000000004084
160.0
PJS3_k127_5646661_242
COG1943 Transposase and inactivated derivatives
-
-
-
0.000000000000000000000000000000000000000001058
159.0
PJS3_k127_5646661_243
COG3678 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein
-
-
-
0.000000000000000000000000000000000000000001549
160.0
PJS3_k127_5646661_246
membrane
-
-
-
0.0000000000000000000000000000000000258
138.0
PJS3_k127_5646661_25
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.0
1054.0
PJS3_k127_5646661_250
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.00000000000000000000000000000004888
126.0
PJS3_k127_5646661_251
O-Antigen ligase
-
-
-
0.0000000000000000000000000000003826
138.0
PJS3_k127_5646661_252
Type 1 pili usher protein CsuD
K07347
-
-
0.0000000000000000000000000003024
133.0
PJS3_k127_5646661_253
-
-
-
-
0.0000000000000000000000000003196
117.0
PJS3_k127_5646661_254
Acyltransferase
-
-
-
0.000000000000000000000000002372
125.0
PJS3_k127_5646661_255
Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1878.0
PJS3_k127_5646661_30
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
0.0
1019.0
PJS3_k127_5646661_31
flavoprotein involved in K transport
-
-
-
0.0
994.0
PJS3_k127_5646661_32
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
6.2e-322
988.0
PJS3_k127_5646661_34
COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
-
-
-
8.321e-314
965.0
PJS3_k127_5646661_35
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
4.539e-313
960.0
PJS3_k127_5646661_36
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
4.094e-311
954.0
PJS3_k127_5646661_37
belongs to the aldehyde dehydrogenase family
K00135
-
1.2.1.16,1.2.1.20,1.2.1.79
5.875e-311
954.0
PJS3_k127_5646661_38
Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase
K03568
-
-
5.811e-309
948.0
PJS3_k127_5646661_39
belongs to the aldehyde dehydrogenase family
-
-
-
5.369e-308
944.0
PJS3_k127_5646661_4
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1877.0
PJS3_k127_5646661_40
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
1.596e-305
942.0
PJS3_k127_5646661_41
Belongs to the MurCDEF family
K01924
-
6.3.2.8
1.935e-305
939.0
PJS3_k127_5646661_42
N-terminal domain of unknown function (DUF4140)
-
-
-
5.643e-301
928.0
PJS3_k127_5646661_43
Na+/Pi-cotransporter
K03324
-
-
2.497e-300
927.0
PJS3_k127_5646661_44
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00627
-
2.3.1.12
8.713e-299
923.0
PJS3_k127_5646661_45
Rossmann fold nucleotide-binding protein
K06966
-
3.2.2.10
1.53e-298
917.0
PJS3_k127_5646661_46
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
3.791e-298
916.0
PJS3_k127_5646661_47
protein conserved in bacteria
-
-
-
6.806e-297
916.0
PJS3_k127_5646661_48
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
1.644e-292
901.0
PJS3_k127_5646661_49
PLD-like domain
-
-
-
1.059e-290
895.0
PJS3_k127_5646661_5
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K01681
-
4.2.1.3
0.0
1838.0
PJS3_k127_5646661_50
COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit
K01474
-
3.5.2.14
5.006e-289
892.0
PJS3_k127_5646661_51
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
8.968e-284
872.0
PJS3_k127_5646661_52
beta-lactamase
K07576
-
-
1.877e-283
874.0
PJS3_k127_5646661_53
Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
K03592
-
-
1.449e-282
870.0
PJS3_k127_5646661_54
COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases
K02433
-
6.3.5.6,6.3.5.7
1.77e-282
871.0
PJS3_k127_5646661_55
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1822.0
PJS3_k127_5646661_60
secreted trypsin-like serine protease
K01325
-
3.4.21.35
2.185e-269
838.0
PJS3_k127_5646661_61
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
2.524e-269
831.0
PJS3_k127_5646661_62
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
2.462e-266
822.0
PJS3_k127_5646661_63
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
1.741e-265
818.0
PJS3_k127_5646661_64
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
3.12e-265
818.0
PJS3_k127_5646661_65
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
6.107e-264
814.0
PJS3_k127_5646661_66
Sulfatase-modifying factor enzyme 1
-
-
-
3.138e-260
806.0
PJS3_k127_5646661_67
aminotransferase
K09459,K10907
-
4.1.1.82
7.782e-259
800.0
PJS3_k127_5646661_68
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
1.074e-258
800.0
PJS3_k127_5646661_69
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
2.084e-257
796.0
PJS3_k127_5646661_7
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1723.0
PJS3_k127_5646661_70
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00823
-
2.6.1.19
1.153e-254
789.0
PJS3_k127_5646661_71
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
1.749e-252
782.0
PJS3_k127_5646661_72
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
2.766e-250
774.0
PJS3_k127_5646661_73
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
6.61e-248
767.0
PJS3_k127_5646661_74
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
7.037e-248
767.0
PJS3_k127_5646661_75
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
3.578e-245
757.0
PJS3_k127_5646661_76
acetylornithine aminotransferase
K00821
-
2.6.1.11,2.6.1.17
1.514e-244
760.0
PJS3_k127_5646661_77
Tartrate dehydrogenase
K07246
-
1.1.1.83,1.1.1.93,4.1.1.73
5.952e-240
744.0
PJS3_k127_5646661_79
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
1.047e-237
737.0
PJS3_k127_5646661_8
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K01595
-
4.1.1.31
0.0
1690.0
PJS3_k127_5646661_80
Long-chain fatty acid transport protein
K06076
-
-
6.887e-233
725.0
PJS3_k127_5646661_81
Belongs to the peptidase S1C family
K04691
-
-
1.051e-232
722.0
PJS3_k127_5646661_82
type II secretion system protein
K02653
-
-
1.384e-231
720.0
PJS3_k127_5646661_83
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
1.475e-229
711.0
PJS3_k127_5646661_84
Reduces the stability of FtsZ polymers in the presence of ATP
K06916
-
-
6.962e-228
708.0
PJS3_k127_5646661_85
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
1.171e-227
706.0
PJS3_k127_5646661_86
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K02346
-
2.7.7.7
6.157e-227
724.0
PJS3_k127_5646661_87
Permease
K07091
-
-
2.61e-226
702.0
PJS3_k127_5646661_88
phosphate-selective porin O and P
-
-
-
4.072e-225
702.0
PJS3_k127_5646661_89
overlaps another CDS with the same product name
K21019
-
2.7.7.65
1.12e-224
699.0
PJS3_k127_5646661_9
-
-
-
-
0.0
1656.0
PJS3_k127_5646661_90
permease
K11720
-
-
1.831e-224
698.0
PJS3_k127_5646661_91
overlaps another CDS with the same product name
K21019
-
2.7.7.65
9.373e-222
689.0
PJS3_k127_5646661_92
Aldo keto reductase
-
-
-
1.518e-221
688.0
PJS3_k127_5646661_93
Belongs to the ABC transporter superfamily
K02010,K02052
-
3.6.3.30
1.023e-220
687.0
PJS3_k127_5646661_94
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
2.513e-220
685.0
PJS3_k127_5646661_95
Rod shape-determining protein
K03569
-
-
1.238e-217
677.0
PJS3_k127_5646661_96
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K07568
-
2.4.99.17
4.64e-217
676.0
PJS3_k127_5646661_97
Peptidoglycan polymerase that is essential for cell division
K03588
-
-
2.54e-213
670.0
PJS3_k127_5646661_98
COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
-
-
-
2.127e-210
655.0
PJS3_k127_5646661_99
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
5.136e-210
655.0
PJS3_k127_891664_1
methylmalonate-semialdehyde dehydrogenase
K00140
-
1.2.1.18,1.2.1.27
1.34e-313
963.0
PJS3_k127_891664_10
Esterase lipase
K01066
-
-
3.384e-214
667.0
PJS3_k127_891664_11
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
4.383e-213
668.0
PJS3_k127_891664_12
helix_turn_helix, arabinose operon control protein
