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Overview

ID MAG03137
Name PYH1_bin.28
Sample SMP0073
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JACTUA01
Species
Assembly information
Completeness (%) 54.86
Contamination (%) 0.49
GC content (%) 66.0
N50 (bp) 2,888
Genome size (bp) 1,039,088

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1270

Gene name Description KEGG GOs EC E-value Score Sequence
PYH1_k127_1006696_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 321.0
PYH1_k127_1006696_1 methanogen marker protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004592 283.0
PYH1_k127_1006696_2 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000003003 254.0
PYH1_k127_1006696_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000004489 123.0
PYH1_k127_1006696_4 transcription factor (CBF NF-Y) - - - 0.00000000000000000000000000001951 117.0
PYH1_k127_102120_0 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 376.0
PYH1_k127_1045497_0 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 578.0
PYH1_k127_1045497_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000005767 57.0
PYH1_k127_1045497_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000184 56.0
PYH1_k127_1045497_3 spectrin binding - - - 0.00002336 54.0
PYH1_k127_1045497_4 - - - - 0.00002493 50.0
PYH1_k127_1048710_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 415.0
PYH1_k127_1048710_1 Replication factor C K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 351.0
PYH1_k127_1048710_2 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000004188 243.0
PYH1_k127_1048710_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000001951 210.0
PYH1_k127_1048710_4 Methyltransferase type 11 - - - 0.00000000000000000009013 91.0
PYH1_k127_1071006_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 597.0
PYH1_k127_1071006_1 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 346.0
PYH1_k127_1071006_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000003477 222.0
PYH1_k127_1071006_3 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000006841 178.0
PYH1_k127_1071006_4 COG0457 FOG TPR repeat - - - 0.000000006327 69.0
PYH1_k127_1088867_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 4.626e-194 614.0
PYH1_k127_1088867_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000001151 108.0
PYH1_k127_1090079_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 538.0
PYH1_k127_1090079_1 - - - - 0.000000000000000000000000002442 119.0
PYH1_k127_1090079_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000006783 49.0
PYH1_k127_1092870_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 576.0
PYH1_k127_1092870_1 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000008341 136.0
PYH1_k127_110445_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 3.715e-250 795.0
PYH1_k127_110445_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000006467 235.0
PYH1_k127_1127083_0 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 324.0
PYH1_k127_1127083_1 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 314.0
PYH1_k127_1128673_0 acid binding OB-fold tRNA helicase-type K07463 - - 5.559e-283 882.0
PYH1_k127_1128673_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 283.0
PYH1_k127_1128673_2 - - - - 0.0000000000000000000000000000000000006565 141.0
PYH1_k127_1128673_3 - - - - 0.0000000000000001367 80.0
PYH1_k127_1142040_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 593.0
PYH1_k127_1142040_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009327 302.0
PYH1_k127_1142040_2 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000002248 94.0
PYH1_k127_1169548_0 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 604.0
PYH1_k127_1169548_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000005069 175.0
PYH1_k127_1198428_0 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000687 547.0
PYH1_k127_1198428_1 - - - - 0.0000000000000000000000000000000000001991 145.0
PYH1_k127_121253_0 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 549.0
PYH1_k127_121253_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000006537 237.0
PYH1_k127_121253_2 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000001217 178.0
PYH1_k127_121253_3 - - - - 0.0001163 51.0
PYH1_k127_125231_0 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 442.0
PYH1_k127_125231_1 dehydratase K01709,K01710 - 4.2.1.45,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008833 370.0
PYH1_k127_125231_2 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 318.0
PYH1_k127_125231_3 TIGRFAM Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000000000000000002383 233.0
PYH1_k127_125231_4 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000181 201.0
PYH1_k127_125231_5 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000004802 203.0
PYH1_k127_125231_6 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000005283 190.0
PYH1_k127_125231_7 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000002566 130.0
PYH1_k127_130832_0 PFAM type II secretion system protein E K07332 - - 4.149e-217 680.0
PYH1_k127_130832_1 type II secretion system protein K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 451.0
PYH1_k127_1318108_0 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006238 407.0
PYH1_k127_1318108_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 306.0
PYH1_k127_1318108_2 - K03561,K12287 - - 0.0000000000000000000000000000005719 139.0
PYH1_k127_1318108_3 - K03561,K12287 - - 0.000000000000000000000000000004328 137.0
PYH1_k127_1332120_0 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 380.0
PYH1_k127_1332120_1 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004402 260.0
PYH1_k127_1332120_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000000000000000000000000000000000000000000000000000006627 271.0
PYH1_k127_1332120_3 LemA family K03744 - - 0.00002389 53.0
PYH1_k127_1348510_0 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 323.0
PYH1_k127_1348510_1 Domain of unknown function (DUF1805) - - - 0.0000000000000000000000000002931 122.0
PYH1_k127_1348510_2 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000004283 88.0
PYH1_k127_1386940_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 5.138e-220 695.0
PYH1_k127_1386940_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 397.0
PYH1_k127_1386940_2 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000002587 264.0
PYH1_k127_1386940_3 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000008898 110.0
PYH1_k127_1388216_0 amino acid K03294 - - 5.864e-223 700.0
PYH1_k127_1388216_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 335.0
PYH1_k127_1388216_2 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000144 273.0
PYH1_k127_1388216_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000006091 280.0
PYH1_k127_1388216_4 metallopeptidase activity - - - 0.00000000000000000000000000000000000001969 149.0
PYH1_k127_1392209_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000003652 231.0
PYH1_k127_1392209_1 Helix-turn-helix domain protein K03627 - - 0.000000000000000000000000000000000000000000002944 171.0
PYH1_k127_1400932_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 386.0
PYH1_k127_1400932_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000006393 249.0
PYH1_k127_1400932_2 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000003365 197.0
PYH1_k127_1400932_3 - K06868 - 2.5.1.73 0.000000000007118 67.0
PYH1_k127_1406659_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 428.0
PYH1_k127_1406659_1 Belongs to the UPF0215 family K09120 - - 0.00000000000000000000000000000000000000000000000000000000000000001656 243.0
PYH1_k127_1406659_2 B-block binding subunit of TFIIIC - - - 0.000000000000000000000000000000000000000000001745 168.0
PYH1_k127_1406659_3 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000000002153 123.0
PYH1_k127_1406659_4 - - - - 0.0000000000006472 77.0
PYH1_k127_1406659_5 - - - - 0.000000004585 66.0
PYH1_k127_1406659_6 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000001373 50.0
PYH1_k127_141981_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000001628 206.0
PYH1_k127_141981_1 PFAM PEGA domain - - - 0.00000000000000000000000000000000000000000000000000000000421 214.0
PYH1_k127_1446646_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 3.702e-294 919.0
PYH1_k127_1446646_1 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 342.0
PYH1_k127_1446646_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003394 279.0
PYH1_k127_1446646_3 KH domain protein K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000001169 237.0
PYH1_k127_1446646_4 KEOPS complex Cgi121-like subunit K09119 - - 0.0000000000000000000000000000000000000001905 155.0
PYH1_k127_1470896_0 type II secretion system protein K07333 - - 3.374e-208 665.0
PYH1_k127_1470896_1 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 456.0
PYH1_k127_1470896_2 - - - - 0.0000000000000000000000000000001959 125.0
PYH1_k127_1470896_3 - - - - 0.00000000000000001052 84.0
PYH1_k127_1485056_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 515.0
PYH1_k127_1485056_1 COG0433 Predicted ATPase - - - 0.0000000000000000009908 90.0
PYH1_k127_1540690_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 5.797e-267 830.0
PYH1_k127_1540690_1 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002978 277.0
PYH1_k127_1585471_0 Involved in protein export K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 296.0
PYH1_k127_1585471_1 Protein-export membrane protein SecD K03072 - - 0.00000000000000000000000000000000000000000000000000001492 195.0
PYH1_k127_1585471_2 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000001076 120.0
PYH1_k127_1586046_0 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 542.0
PYH1_k127_1586046_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 503.0
PYH1_k127_1586046_2 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 326.0
PYH1_k127_1586046_3 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000004851 262.0
PYH1_k127_1586046_4 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000006046 231.0
PYH1_k127_1586046_5 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000000000000000000000002531 180.0
PYH1_k127_1586046_6 - - - - 0.00000000000000000000000000000000001274 145.0
PYH1_k127_1606509_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000001015 228.0
PYH1_k127_1606509_1 type II secretion system protein K07333 - - 0.00000000000000000000000000000000000000001099 158.0
PYH1_k127_1613178_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 501.0
PYH1_k127_1613178_1 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000000000000000000000000000000002022 199.0
PYH1_k127_1613178_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000002959 88.0
PYH1_k127_1614563_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 353.0
PYH1_k127_1614563_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000001959 214.0
PYH1_k127_1614563_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000003014 99.0
PYH1_k127_1622720_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 338.0
PYH1_k127_1622720_1 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000003289 206.0
PYH1_k127_1622720_2 - - - - 0.0000000000000000000000000000000000000000000000000005342 195.0
PYH1_k127_1632632_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 588.0
PYH1_k127_1632632_1 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 334.0
PYH1_k127_1670295_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 413.0
PYH1_k127_1670295_1 involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000000000000000007852 155.0
PYH1_k127_1670295_2 - - - - 0.000000000000000009947 88.0
PYH1_k127_1670295_3 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000002609 59.0
PYH1_k127_1690022_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 465.0
PYH1_k127_1690022_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 427.0
PYH1_k127_170743_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 7.263e-267 829.0
PYH1_k127_170743_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 298.0
PYH1_k127_170743_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000014 237.0
PYH1_k127_170743_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000001099 107.0
PYH1_k127_1714042_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007967 350.0
PYH1_k127_1717458_0 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008508 445.0
PYH1_k127_1717458_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 323.0
PYH1_k127_1717458_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000003198 206.0
PYH1_k127_1779308_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 537.0
PYH1_k127_1779308_1 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008823 447.0
PYH1_k127_1779308_2 Domain of unknown function (DUF4405) - - - 0.00001003 51.0
PYH1_k127_1783702_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000409 248.0
PYH1_k127_1783702_1 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000001695 218.0
PYH1_k127_1783702_2 PFAM Thioredoxin K03671 - - 0.0000000000000000000000000000004466 126.0
PYH1_k127_1800511_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 474.0
PYH1_k127_1800511_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 342.0
PYH1_k127_1800511_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 347.0
PYH1_k127_1800511_3 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 314.0
PYH1_k127_1800511_4 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000009586 145.0
PYH1_k127_1800511_5 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000001618 135.0
PYH1_k127_1869657_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 390.0
PYH1_k127_1869657_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000001168 80.0
PYH1_k127_1869657_2 Hsp20/alpha crystallin family K13993 - - 0.0000000000004774 75.0
PYH1_k127_1872252_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004728 274.0
PYH1_k127_1872252_1 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002523 267.0
PYH1_k127_1872252_2 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000001952 103.0
PYH1_k127_1872252_3 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000000002618 64.0
PYH1_k127_1923280_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000001027 230.0
PYH1_k127_1923280_1 diguanylate cyclase - - - 0.00000000000004803 86.0
PYH1_k127_1968136_0 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002253 275.0
PYH1_k127_1968136_1 Small multi-drug export protein - - - 0.0000000000000000000000000000000006206 139.0
PYH1_k127_1968136_2 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000008905 78.0
PYH1_k127_1975609_0 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 286.0
PYH1_k127_1975609_1 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000008403 209.0
PYH1_k127_1975609_2 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000003274 207.0
PYH1_k127_1981968_0 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000341 240.0
PYH1_k127_1981968_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000002809 221.0
PYH1_k127_1981968_2 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000000000000000000000000009489 189.0
PYH1_k127_1981968_3 Dihydrouridine synthase (Dus) - - - 0.00000003294 55.0
PYH1_k127_1991010_0 Protein of unknown function, DUF255 K06888 - - 1.526e-221 707.0
PYH1_k127_1991010_1 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 2.579e-205 651.0
PYH1_k127_1991010_2 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 309.0
PYH1_k127_1991010_3 - - - - 0.000000000000000000000002274 107.0
PYH1_k127_1991010_4 - - - - 0.0000000000001162 81.0
PYH1_k127_1991010_5 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000001221 67.0
PYH1_k127_2007381_0 TIGRFAM cell division ATPase MinD K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005665 346.0
PYH1_k127_2007381_1 - - - - 0.0000000000004995 77.0
PYH1_k127_2022665_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1040.0
PYH1_k127_2022665_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 363.0
PYH1_k127_2022665_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000008162 197.0
PYH1_k127_2022665_3 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000001221 97.0
PYH1_k127_2038641_0 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004826 271.0
PYH1_k127_2038641_1 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009615 250.0
PYH1_k127_2038641_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000001733 181.0
PYH1_k127_2038641_3 - - - - 0.000000001584 62.0
PYH1_k127_2050690_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 4.221e-228 716.0
PYH1_k127_2050690_1 - - - - 0.00000000000001116 76.0
PYH1_k127_2080327_0 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 589.0
PYH1_k127_2080327_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 316.0
PYH1_k127_2080327_2 DNA binding protein K06930 - - 0.00000006605 54.0
PYH1_k127_2110490_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 6.324e-255 808.0
PYH1_k127_2110490_1 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000000001171 124.0
PYH1_k127_2117270_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 599.0
PYH1_k127_2127917_0 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 406.0
PYH1_k127_2127917_1 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008064 247.0
PYH1_k127_2127917_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000008018 165.0
PYH1_k127_2127917_3 PFAM major facilitator superfamily MFS_1 K08223 - - 0.00000000000000000001468 94.0
PYH1_k127_2167970_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 587.0
PYH1_k127_2167970_1 - - - - 0.00000000000000000000000000000000006639 144.0
PYH1_k127_2167970_2 - - - - 0.0009869 50.0
PYH1_k127_219467_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 474.0
PYH1_k127_219467_1 Polysaccharide biosynthesis protein K01711,K15856 - 1.1.1.281,4.2.1.47 0.000000000000000000000000000000000000000000009287 175.0
PYH1_k127_219467_2 Nucleotidyl transferase - - - 0.000000000000001015 78.0
PYH1_k127_2202128_0 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 316.0
PYH1_k127_2202128_1 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000003041 195.0
PYH1_k127_2202128_2 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000198 147.0
PYH1_k127_2224401_0 Belongs to the glutamate synthase family - - - 1.006e-226 706.0
PYH1_k127_2224401_1 PFAM glutamate synthase alpha subunit domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003104 282.0
PYH1_k127_2254694_0 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004159 239.0
PYH1_k127_2254694_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000004058 227.0
PYH1_k127_2254694_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000003312 198.0
PYH1_k127_2254694_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000000002925 91.0
PYH1_k127_2307470_0 PFAM response regulator receiver K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 404.0
PYH1_k127_2307470_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000007562 72.0
PYH1_k127_230933_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 313.0
PYH1_k127_230933_1 SMART zinc finger, CDGSH-type domain protein - - - 0.000000000000000000000000000000001716 132.0
PYH1_k127_2333904_0 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 419.0
PYH1_k127_2333904_1 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000001339 171.0
PYH1_k127_2333904_2 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000003566 158.0
PYH1_k127_2343030_0 2Fe-2S iron-sulfur cluster binding domain - - - 6.817e-222 694.0
PYH1_k127_2343030_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 443.0
PYH1_k127_2343030_2 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002707 294.0
PYH1_k127_2343030_3 COG0515 Serine threonine protein kinase - - - 0.000005945 49.0
PYH1_k127_2343634_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 473.0
PYH1_k127_2343634_1 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 366.0
PYH1_k127_2343634_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 307.0
PYH1_k127_2368728_0 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000001309 192.0
PYH1_k127_2368728_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000003475 191.0
PYH1_k127_2368728_2 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000001749 55.0
PYH1_k127_2416941_0 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002243 248.0
PYH1_k127_2416941_1 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001325 241.0
PYH1_k127_2416941_2 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000000000000003078 166.0
PYH1_k127_2431796_0 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 351.0
PYH1_k127_2431796_1 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000000000003376 193.0
PYH1_k127_2431796_2 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000004638 146.0
PYH1_k127_2448971_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 600.0
PYH1_k127_2448971_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000004377 237.0
PYH1_k127_2448971_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000001146 225.0
PYH1_k127_2448971_3 - - - - 0.0000000000000000000000000003797 117.0
PYH1_k127_2448971_4 Helix-turn-helix XRE-family like proteins K07729 - - 0.000000000000000000001083 96.0
PYH1_k127_2455816_0 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002271 282.0
PYH1_k127_2455816_1 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009063 256.0
PYH1_k127_2476230_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 466.0
PYH1_k127_2505425_0 Domain of unknown function (DUF814) - - - 6.782e-229 725.0
PYH1_k127_2505425_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 411.0
PYH1_k127_2505425_2 in RNase L inhibitor, RLI K06174 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 295.0
PYH1_k127_2505425_3 RNase L inhibitor, RLI - - - 0.000000000000000000000002978 109.0
PYH1_k127_2521529_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 2.336e-238 747.0
PYH1_k127_2521529_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 5.603e-194 614.0
PYH1_k127_2521529_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 289.0
PYH1_k127_2521529_3 - - - - 0.000000000000000000000000000000000000001222 158.0
PYH1_k127_2521529_4 RNA methylase K07446 - 2.1.1.213 0.000000000000000000003135 95.0
PYH1_k127_2528776_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 422.0
PYH1_k127_2528776_1 Peptidyl-prolyl cis-trans isomerase K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000009412 184.0
PYH1_k127_2530205_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000753 337.0
PYH1_k127_2530205_1 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 323.0
PYH1_k127_2530205_2 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000000000000000000006671 233.0
PYH1_k127_2535351_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.243e-216 685.0
PYH1_k127_2535351_1 Chromate transporter K07240 - - 0.000000000000000000000000000001097 124.0
PYH1_k127_2543453_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 437.0
PYH1_k127_2543453_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 386.0
PYH1_k127_2549699_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 544.0
PYH1_k127_2549699_1 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000005893 260.0
PYH1_k127_2549699_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000008269 251.0
PYH1_k127_2553808_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001453 270.0
PYH1_k127_2553808_1 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000001758 230.0
PYH1_k127_2553808_2 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000044 106.0
PYH1_k127_2553808_3 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000000001491 88.0
PYH1_k127_2554322_0 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009076 426.0
PYH1_k127_2554322_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 326.0
PYH1_k127_2554322_2 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000000000000000002196 91.0
PYH1_k127_2554322_3 nitrite reductase [NAD(P)H] activity K05710 - - 0.000000000000008303 78.0
PYH1_k127_2554322_4 - - - - 0.00002238 55.0
PYH1_k127_2575880_0 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 389.0
PYH1_k127_2575880_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000238 253.0
PYH1_k127_2594312_0 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000008021 204.0
PYH1_k127_2594312_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000005445 192.0
PYH1_k127_2596298_0 Nitrite and sulphite reductase 4Fe-4S - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 304.0
PYH1_k127_2596298_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000002134 218.0
PYH1_k127_2596298_2 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000007713 228.0
PYH1_k127_2596298_3 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000002243 195.0
PYH1_k127_2596298_4 Domain of unknown function (DUF4349) - - - 0.00000000000000000000000000000000000000000000001047 176.0
PYH1_k127_2596298_5 - - - - 0.0000000000000000000000000006677 115.0
PYH1_k127_2602695_0 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 289.0
PYH1_k127_2625591_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 579.0
PYH1_k127_2625591_1 PFAM ABC transporter related K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 400.0
PYH1_k127_2625591_2 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000001307 169.0
PYH1_k127_2625591_3 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000002212 148.0
PYH1_k127_2634528_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 420.0
PYH1_k127_2656616_0 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001267 276.0
PYH1_k127_2656616_1 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000001577 166.0
PYH1_k127_2656616_2 - - - - 0.00000000000000000000000000000000000000000003366 179.0
PYH1_k127_2666523_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 451.0
PYH1_k127_2666523_1 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000001354 156.0
PYH1_k127_2716006_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000001014 217.0
PYH1_k127_2716006_1 PFAM TrkA-C domain K07228 - - 0.0000000000000000000000000000000000000000000000000000002751 199.0
PYH1_k127_2716006_2 PFAM sodium hydrogen exchanger K03455 - - 0.00000000000000000000649 94.0
PYH1_k127_2753391_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 399.0
PYH1_k127_2753391_1 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000001797 162.0
PYH1_k127_2768398_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 467.0
PYH1_k127_2768398_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002746 280.0
PYH1_k127_2768398_2 Helix-turn-helix domain - - - 0.00000000000000000000000000000000001942 144.0
PYH1_k127_2768398_3 PFAM Linocin_M18 bacteriocin protein - - - 0.00000000000000000307 85.0
PYH1_k127_2802277_0 Domain of unknown function DUF128 K21640 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 324.0
PYH1_k127_2802277_1 PFAM transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000000000000000000000006091 220.0
PYH1_k127_2802277_2 - - - - 0.0000000000000000000000000000000000000002305 155.0
PYH1_k127_2883564_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 572.0
PYH1_k127_2883564_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000001217 212.0
PYH1_k127_289641_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004785 469.0
PYH1_k127_289641_1 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 0.00000000000000000000000000000000000000000000000000000000000168 212.0
PYH1_k127_2912185_0 Ras family K06945 - - 0.00000000000000000000000000000000000000000000000000003376 193.0
PYH1_k127_2912185_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000002267 136.0
PYH1_k127_2912185_2 - - - - 0.00000000000000000000000000001904 125.0
PYH1_k127_2912185_4 - - - - 0.000000000000005276 80.0
PYH1_k127_2912185_5 - - - - 0.000611 46.0
PYH1_k127_2912923_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 441.0
PYH1_k127_2912923_1 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000002482 245.0
PYH1_k127_2934828_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 8.73e-262 819.0
PYH1_k127_2934828_1 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000001028 190.0
PYH1_k127_2934828_2 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000000005511 99.0
PYH1_k127_2959772_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 537.0
PYH1_k127_2959772_1 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000000000000000000000000000001177 213.0
PYH1_k127_2959772_2 formamidopyrimidine-DNA glycosylase K05522 - 4.2.99.18 0.00000000000000000000000000000000003309 141.0
PYH1_k127_2959772_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000000000000006083 125.0
PYH1_k127_2979095_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000002265 231.0
PYH1_k127_2979095_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000005735 222.0
PYH1_k127_2979095_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895,K01908 - 6.2.1.1,6.2.1.17 0.0009684 46.0
PYH1_k127_3021399_0 Cytidylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000006066 236.0
PYH1_k127_3021399_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000009304 175.0
PYH1_k127_3022399_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 397.0
PYH1_k127_3022399_1 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003002 287.0
PYH1_k127_3022399_2 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000003882 164.0
PYH1_k127_3022399_3 zinc finger, SWIM - - - 0.0000000000000000000000000006155 119.0
PYH1_k127_3116271_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 5.944e-202 638.0
PYH1_k127_3116271_1 N-6 DNA Methylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009239 473.0
PYH1_k127_3119854_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 556.0
PYH1_k127_3119854_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 335.0
PYH1_k127_3119854_2 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000002822 198.0
PYH1_k127_3130362_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 367.0
PYH1_k127_3130362_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 305.0
PYH1_k127_3130362_2 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000000000000000258 151.0
PYH1_k127_3130362_3 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000003001 139.0
PYH1_k127_3130362_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000001242 136.0
PYH1_k127_3139772_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 393.0
PYH1_k127_3139772_1 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 377.0
PYH1_k127_3139772_2 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000000000000000000000000001003 195.0
PYH1_k127_3139772_3 - - - - 0.0000000000000005996 84.0
PYH1_k127_3139772_4 Belongs to the small heat shock protein (HSP20) family - - - 0.00000006489 60.0
PYH1_k127_3172876_0 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006323 522.0
PYH1_k127_3172876_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 297.0
PYH1_k127_3172876_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000004729 145.0
PYH1_k127_3178245_0 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008839 347.0
PYH1_k127_3178245_1 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000001555 194.0
PYH1_k127_3178245_2 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000000000000000000000001761 190.0
PYH1_k127_3288512_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007529 311.0
PYH1_k127_3288512_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000001125 177.0
PYH1_k127_3290960_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 9.702e-233 736.0
PYH1_k127_3290960_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000005826 93.0
PYH1_k127_3291486_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1245.0
PYH1_k127_3291486_1 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 400.0
PYH1_k127_3291486_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.000000000000000000000000000000000000000000000000000000000000003876 222.0
PYH1_k127_3302607_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 603.0
PYH1_k127_3302607_1 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 373.0
PYH1_k127_3308774_0 DEAD DEAH box helicase K06877 - - 8.099e-290 909.0
PYH1_k127_3308774_1 Exonuclease K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001468 284.0
PYH1_k127_3308774_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001654 275.0
PYH1_k127_3308774_3 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000344 239.0
PYH1_k127_3308774_4 NTPase - - - 0.0000000000000000000000000000000000000007986 154.0
PYH1_k127_3308774_5 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000003561 76.0
PYH1_k127_334724_0 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000004069 260.0
PYH1_k127_334724_1 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000000000000007628 181.0
PYH1_k127_334724_2 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.00000000000000000001099 92.0
PYH1_k127_335861_0 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 299.0
PYH1_k127_335861_1 Dual specificity phosphatase, catalytic domain - - - 0.00000000000000000872 90.0
PYH1_k127_335861_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000007742 54.0
PYH1_k127_335861_3 Aldo/keto reductase family K07079 - - 0.0000002632 52.0
PYH1_k127_3387309_0 PFAM TatD-related deoxyribonuclease K07049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 389.0
PYH1_k127_3387309_1 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004653 271.0
PYH1_k127_3387309_2 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000799 130.0
PYH1_k127_3387309_3 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000115 112.0
PYH1_k127_3435669_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000001273 235.0
PYH1_k127_3435669_1 - - - - 0.000000000000000003855 87.0
PYH1_k127_3435669_2 - - - - 0.0000000214 55.0
PYH1_k127_344986_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 282.0
PYH1_k127_344986_1 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000001228 218.0
PYH1_k127_344986_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000003708 196.0
PYH1_k127_344986_3 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000002447 130.0
PYH1_k127_344986_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000002326 122.0
PYH1_k127_344986_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000000002795 94.0
PYH1_k127_3451569_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.012e-215 676.0
PYH1_k127_3451569_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 558.0
PYH1_k127_3451569_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 437.0
PYH1_k127_3451569_3 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000000000000000000000000000000000001628 229.0
PYH1_k127_3451569_4 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000002536 179.0
PYH1_k127_3451569_5 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000000000000000008872 166.0
PYH1_k127_3451569_6 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000002483 152.0
PYH1_k127_3464647_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 372.0
PYH1_k127_3464647_1 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000000000000000000000000001571 123.0
PYH1_k127_3464647_2 Sodium/hydrogen exchanger family K03455 - - 0.0000000000000000000000001871 120.0
PYH1_k127_3470797_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 6.103e-238 745.0
PYH1_k127_3489327_0 COG1668 ABC-type Na efflux pump, permease component - - - 5.041e-205 654.0
PYH1_k127_3489327_1 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 428.0
PYH1_k127_3489327_2 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 369.0
PYH1_k127_3489327_3 - - - - 0.00000000000000000000000001076 117.0
PYH1_k127_3489327_4 - - - - 0.00001273 54.0
PYH1_k127_3514311_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 517.0
PYH1_k127_3514311_1 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
PYH1_k127_3514311_2 TfuA-like protein - - - 0.00000000000000000000000000000000000000009182 158.0
PYH1_k127_3514311_3 Glutaredoxin - - - 0.00000000000000000000000000003174 118.0
PYH1_k127_3514311_4 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000001761 85.0
PYH1_k127_3514311_5 Glutaredoxin - - - 0.000000000000007718 83.0
PYH1_k127_3523885_0 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 448.0
PYH1_k127_3533409_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 430.0
PYH1_k127_3533409_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 291.0
PYH1_k127_3533409_2 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001001 283.0
PYH1_k127_3533409_3 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000001505 127.0
PYH1_k127_3538179_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 5.252e-267 835.0
PYH1_k127_3538179_1 - - - - 0.0000000000003417 77.0
PYH1_k127_3557559_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 465.0
PYH1_k127_3557559_1 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 289.0
PYH1_k127_3575504_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 416.0
PYH1_k127_3575504_1 Domain of unknown function (DUF1917) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 291.0
PYH1_k127_3575504_2 ROK family - - - 0.000002576 55.0
PYH1_k127_3583968_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.839e-198 626.0
PYH1_k127_3583968_1 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 359.0
PYH1_k127_3598628_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 524.0
PYH1_k127_3598628_1 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 445.0
PYH1_k127_3598628_2 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 369.0
PYH1_k127_3598628_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000008987 228.0
PYH1_k127_3598628_4 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000001573 130.0
PYH1_k127_3598628_5 HEAT repeat - - - 0.00000000000000000000000009258 117.0
PYH1_k127_3598628_6 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000001206 106.0
PYH1_k127_3606564_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 487.0
PYH1_k127_3606564_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 360.0
PYH1_k127_3628831_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 438.0
PYH1_k127_3628831_1 TIGRFAM PAS sensor protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007293 259.0
PYH1_k127_3641316_0 PFAM PilT protein domain protein K06865 - - 3.516e-195 616.0
PYH1_k127_3641316_1 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005308 280.0
PYH1_k127_3641316_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000001179 188.0
PYH1_k127_3641316_3 4Fe-4S dicluster domain - - - 0.00000000000000006654 81.0
PYH1_k127_3648877_0 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 424.0
PYH1_k127_3648877_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000002027 104.0
PYH1_k127_3689098_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004355 273.0
PYH1_k127_3689098_1 PHP-associated - - - 0.000000000000000000831 90.0
PYH1_k127_3689098_2 Sodium Bile acid symporter family K03453 - - 0.000000000871 66.0
PYH1_k127_3694604_0 TIGRFAM PAS sensor protein - - - 0.0000000000000000000000000000000000000001829 168.0
PYH1_k127_3701479_0 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 358.0
PYH1_k127_3701479_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002241 258.0
PYH1_k127_3701479_2 Domain of unknown function (DUF1858) - - - 0.00000000000000000000002082 100.0
PYH1_k127_3714057_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 332.0
PYH1_k127_3714057_1 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002163 261.0
PYH1_k127_3765427_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 398.0
PYH1_k127_3765427_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000002062 141.0
PYH1_k127_3773709_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.008e-231 721.0
PYH1_k127_3773709_1 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 539.0
PYH1_k127_3773709_2 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 417.0
PYH1_k127_3773709_3 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000003951 202.0
PYH1_k127_3773709_4 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000008268 170.0
PYH1_k127_3773709_5 - - - - 0.0000000000000000000000000000000002684 136.0
PYH1_k127_3782218_0 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 569.0
PYH1_k127_379921_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 528.0
PYH1_k127_379921_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 406.0
PYH1_k127_379921_2 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 311.0
PYH1_k127_379921_3 DNA polymerase LigD, polymerase K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000001513 225.0
PYH1_k127_379921_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000001165 189.0
PYH1_k127_3814267_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 477.0
PYH1_k127_3814267_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 288.0
PYH1_k127_3814267_2 amino acid K16263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004789 272.0
PYH1_k127_3814267_3 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000003102 226.0
PYH1_k127_3814267_4 - - - - 0.0000000000000000000003506 101.0
PYH1_k127_3863062_0 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 467.0
PYH1_k127_3863062_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 440.0
PYH1_k127_3863062_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 289.0
PYH1_k127_3868160_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 544.0
PYH1_k127_3868160_1 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 356.0
PYH1_k127_3868160_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000004641 147.0
PYH1_k127_3868160_3 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000001558 74.0
PYH1_k127_3920744_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003792 238.0
PYH1_k127_3920744_1 WD-40 repeat - - - 0.0000000000000000000000000001498 130.0
PYH1_k127_3920744_2 - - - - 0.0000000000003198 82.0
PYH1_k127_3973455_0 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000131 287.0
PYH1_k127_3973455_1 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000419 171.0
PYH1_k127_4001878_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 358.0
PYH1_k127_4001878_1 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 319.0
PYH1_k127_4001878_2 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 284.0
PYH1_k127_4001878_3 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000003862 250.0
PYH1_k127_4001878_4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000003832 69.0
PYH1_k127_4033455_0 Anion transporter K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 471.0
PYH1_k127_4033455_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000001864 205.0
PYH1_k127_4033455_2 Acetyltransferase (GNAT) domain K03824 - - 0.0000000000000000000000000000000000000000000000000000002982 204.0
PYH1_k127_4035413_0 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 370.0
PYH1_k127_4035413_1 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 342.0
PYH1_k127_4035413_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 320.0
PYH1_k127_4035413_3 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000007444 254.0
PYH1_k127_405391_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 420.0
PYH1_k127_405391_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 361.0
PYH1_k127_405391_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000002242 228.0
PYH1_k127_405391_3 - - - - 0.0000000000000000000000000000000000000000000000000000004475 198.0
PYH1_k127_405391_4 glycosyl transferase, family 39 - - - 0.00000000000000000000000001387 113.0
PYH1_k127_4087087_0 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 284.0
PYH1_k127_4087087_1 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000002069 164.0
PYH1_k127_4094257_0 STAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 613.0
PYH1_k127_4094257_1 Peptidyl-prolyl cis-trans isomerase K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000004215 126.0
PYH1_k127_4101624_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 485.0
PYH1_k127_4101624_1 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 335.0
PYH1_k127_4156190_0 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 311.0
PYH1_k127_4156190_1 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000006388 152.0
PYH1_k127_4156190_2 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000001249 140.0
PYH1_k127_4166897_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 475.0
PYH1_k127_4166897_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000002374 104.0
PYH1_k127_4166897_2 Threonine dehydratase K01754 - 4.3.1.19 0.00000000001356 78.0
PYH1_k127_4174190_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 7.655e-224 708.0
PYH1_k127_4174190_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.000002321 50.0
PYH1_k127_4197846_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 501.0
PYH1_k127_4197846_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 418.0
PYH1_k127_4197846_2 HTH-type transcriptional regulatory protein K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 360.0
PYH1_k127_4197846_3 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000001007 230.0
PYH1_k127_4199519_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 4.72e-279 883.0
PYH1_k127_4199519_1 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000002491 125.0
PYH1_k127_4207110_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000007766 237.0
PYH1_k127_4207110_1 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000002652 195.0
PYH1_k127_4207110_2 PFAM Beta propeller domain K14475 - - 0.0000000000000000000000000000000000000000000004615 175.0
PYH1_k127_4207110_3 E-Z type HEAT repeats - - - 0.00002835 50.0
PYH1_k127_4241058_0 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 444.0
PYH1_k127_4241058_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000001965 226.0
PYH1_k127_4253313_0 CBS domain containing protein K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 450.0
PYH1_k127_4253313_1 Small multi-drug export protein - - - 0.00000000000000000000000000000000000002535 152.0
PYH1_k127_4329285_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 556.0
PYH1_k127_4329285_1 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 380.0
PYH1_k127_4329285_2 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000001043 217.0
PYH1_k127_4329285_3 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000000000000000000002248 94.0
PYH1_k127_4344678_0 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 586.0
PYH1_k127_4344678_1 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 515.0
PYH1_k127_4344678_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0005888 47.0
PYH1_k127_4352528_0 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 337.0
PYH1_k127_4352528_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 297.0
PYH1_k127_4352528_2 - - - - 0.0000000000000000000000000000000000000000000000005045 181.0
PYH1_k127_4352528_3 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000000000001932 165.0
PYH1_k127_4375140_0 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000128 209.0
PYH1_k127_4375140_1 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000006577 211.0
PYH1_k127_4375140_2 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000004896 175.0
PYH1_k127_4375140_3 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000008311 109.0
PYH1_k127_4425261_0 PFAM TrkA-N domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 530.0
PYH1_k127_4425261_1 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005996 292.0
PYH1_k127_4425347_0 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000001038 224.0
PYH1_k127_4425347_1 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000002137 149.0
PYH1_k127_4425347_2 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000329 112.0
PYH1_k127_4425347_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000002833 90.0
PYH1_k127_4425347_4 Probably involved in the biogenesis of the ribosome K14561 - - 0.000000000000001889 83.0
PYH1_k127_4425347_5 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000000000007485 75.0
PYH1_k127_4437178_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 462.0
PYH1_k127_4437178_1 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 327.0
PYH1_k127_4437178_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 322.0
PYH1_k127_4447925_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 8.269e-240 750.0
PYH1_k127_4447925_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000001003 252.0
PYH1_k127_4447925_2 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000000002311 93.0
PYH1_k127_4447925_3 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00006125 48.0
PYH1_k127_4490592_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 2.806e-211 665.0
PYH1_k127_4490592_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000003084 132.0
PYH1_k127_4512499_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 4.576e-203 638.0
PYH1_k127_4512499_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000001491 189.0
PYH1_k127_4512499_2 - - - - 0.000006756 54.0
PYH1_k127_451520_0 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 306.0
PYH1_k127_451520_1 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000001324 245.0
PYH1_k127_45222_0 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 370.0
PYH1_k127_45222_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 325.0
PYH1_k127_45222_2 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 317.0
PYH1_k127_4542762_0 PFAM PEGA domain - - - 0.0000000000000000000000000000000000000000000001422 176.0
PYH1_k127_4542762_1 - - - - 0.0000000000000000000000000000000000001542 147.0
PYH1_k127_4542762_2 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000001031 120.0
PYH1_k127_4575191_0 WD-40 repeat - - - 0.000000000000000186 93.0
PYH1_k127_4575191_1 - - - - 0.00000003865 66.0
PYH1_k127_4682978_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.905e-203 647.0
PYH1_k127_4682978_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 318.0
PYH1_k127_4682978_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000001108 86.0
PYH1_k127_4684446_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 577.0
PYH1_k127_4684446_1 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004342 254.0
PYH1_k127_4684446_2 NMT1-like family K02051 - - 0.00000000000000000000000000000289 124.0
PYH1_k127_4684446_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000171 63.0
PYH1_k127_4696774_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 538.0
PYH1_k127_4696774_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 286.0
PYH1_k127_4697976_0 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 320.0
PYH1_k127_4697976_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000001524 229.0
PYH1_k127_4697976_2 Sugar efflux transporter for intercellular exchange K15383 - - 0.00000000000000000001024 94.0
PYH1_k127_4697976_3 Protein of unknown function (DUF1624) - - - 0.0000000000000582 77.0
PYH1_k127_4718257_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.897e-271 846.0
PYH1_k127_4718257_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008174 417.0
PYH1_k127_4718257_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000001242 111.0
PYH1_k127_4726431_0 Protein of unknown function (DUF460) K09150 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 420.0
PYH1_k127_4726431_1 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 329.0
PYH1_k127_4726431_2 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000002877 197.0
PYH1_k127_4733611_0 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 494.0
PYH1_k127_4733611_1 - - - - 0.0000000000000004619 82.0
PYH1_k127_4754772_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 454.0
PYH1_k127_4754772_1 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 409.0
PYH1_k127_4754772_2 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 321.0
PYH1_k127_4754772_3 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 297.0
PYH1_k127_4754772_4 - - - - 0.000000000000000000000000001182 117.0
PYH1_k127_4754772_5 signal transduction protein with CBS domains K07744 - - 0.00000003061 54.0
PYH1_k127_4756349_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 500.0
PYH1_k127_4756349_1 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000000000002237 192.0
PYH1_k127_4756349_2 Sulphur transport K07112 - - 0.0000000000000003914 79.0
PYH1_k127_477290_0 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 296.0
PYH1_k127_477290_1 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000000000000002791 222.0
PYH1_k127_477290_2 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000001604 131.0
PYH1_k127_477290_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.0000000000003772 68.0
PYH1_k127_4777237_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 586.0
PYH1_k127_4777237_1 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 417.0
PYH1_k127_4777237_2 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.00006547 45.0
PYH1_k127_4779640_0 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 391.0
PYH1_k127_4779640_1 - - - - 0.00000000000000000000000000000000000000000000000003246 187.0
PYH1_k127_4779640_2 ATP-grasp domain K06914 - 6.3.4.24 0.00000000000000000000000000000000000000001251 155.0
PYH1_k127_4779640_3 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0000000000000000000000003541 104.0
PYH1_k127_4802641_0 PFAM PEGA domain - - - 0.000000000000000000000004112 116.0
PYH1_k127_4802641_1 bile acid:sodium symporter activity K03453 - - 0.000000000000000000004038 102.0
PYH1_k127_4802641_2 Sodium Bile acid symporter family K03453 - - 0.000000001674 62.0
PYH1_k127_4802935_0 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005216 264.0
PYH1_k127_4802935_1 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000001325 220.0
PYH1_k127_4840320_0 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009775 299.0
PYH1_k127_4878088_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 477.0
PYH1_k127_4895175_0 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 304.0
PYH1_k127_4895175_1 Phosphate-starvation-inducible E - - - 0.0000000000000000000003154 98.0
PYH1_k127_4895175_2 - - - - 0.000000000001049 78.0
PYH1_k127_4898101_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 1.063e-280 873.0
PYH1_k127_4898101_1 TIGRFAM PAS sensor protein - - - 0.0000000000000000000000000000000000000000000122 167.0
PYH1_k127_4898101_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000000000000000005109 117.0
PYH1_k127_4900590_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 587.0
PYH1_k127_4900590_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.0000000000000000000000000000000000000000000312 165.0
PYH1_k127_4900590_2 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000009605 152.0
PYH1_k127_4900590_3 - - - - 0.0000000000000000000000000000000000003731 145.0
PYH1_k127_4911232_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 602.0
PYH1_k127_4911232_1 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000000000000005327 158.0
PYH1_k127_4911232_2 beta-lactamase domain protein - - - 0.000000000000000000000005183 108.0
PYH1_k127_4911232_3 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000001207 74.0
PYH1_k127_4911232_4 Metallo-beta-lactamase superfamily - - - 0.00000000000003303 75.0
PYH1_k127_4911232_5 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000001357 68.0
PYH1_k127_4917262_0 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 284.0
PYH1_k127_4917262_1 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007484 263.0
PYH1_k127_4918085_0 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000002493 166.0
PYH1_k127_4918085_1 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000006236 111.0
PYH1_k127_4918085_2 - - - - 0.000000000000000000000008473 103.0
PYH1_k127_4918085_3 Domain of unknown function (DUF1894) - - - 0.000000000003827 70.0
PYH1_k127_4926472_0 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003295 342.0
PYH1_k127_4926472_1 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000004068 177.0
PYH1_k127_4938838_0 PFAM peptidase U32 K08303 - - 1.283e-213 692.0
PYH1_k127_4938838_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 476.0
PYH1_k127_4938838_2 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 349.0
PYH1_k127_4938838_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005278 271.0
PYH1_k127_4938838_4 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000001117 218.0
PYH1_k127_4938838_5 - - - - 0.0000000000000000000000000000000000002846 152.0
PYH1_k127_4938838_6 - K03686 - - 0.0000000000000000000002508 98.0
PYH1_k127_4938838_7 phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 0.000006013 48.0
PYH1_k127_4990119_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003479 270.0
PYH1_k127_4990119_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000000000000001013 177.0
PYH1_k127_4990119_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000000004438 126.0
PYH1_k127_5012525_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 1.115e-218 689.0
PYH1_k127_5012525_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 446.0
PYH1_k127_5012525_2 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000005813 184.0
PYH1_k127_5012525_3 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000001533 159.0
PYH1_k127_5012525_4 binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000002363 138.0
PYH1_k127_5012525_5 metal-binding protein - - - 0.0000000000000000000000000001029 119.0
PYH1_k127_5028192_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000003168 233.0
PYH1_k127_5028192_1 PFAM peptidase K07386 - - 0.000000000000000000000000000000000000004447 148.0
PYH1_k127_5035701_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 366.0
PYH1_k127_5035701_1 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 353.0
PYH1_k127_5035701_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000000000000000000000009792 223.0
PYH1_k127_5035701_3 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000001125 213.0
PYH1_k127_5035701_4 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000003957 220.0
PYH1_k127_5053819_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 574.0
PYH1_k127_5053819_1 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 398.0
PYH1_k127_5053819_2 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000002354 231.0
PYH1_k127_5053819_3 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000000005068 190.0
PYH1_k127_5099143_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 2.352e-202 638.0
PYH1_k127_5099143_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005242 254.0
PYH1_k127_5099143_2 - - - - 0.00000000000000000000000000000000004663 144.0
PYH1_k127_5099143_3 Lysine exporter protein LysE YggA - - - 0.0000000000000009033 88.0
PYH1_k127_5123290_0 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 321.0
PYH1_k127_5123290_1 membrane-associated protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003806 272.0
PYH1_k127_5123290_2 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000001162 183.0
PYH1_k127_5123290_3 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000001281 178.0
PYH1_k127_5123290_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000003092 159.0
PYH1_k127_5123290_5 - - - - 0.00000000000000000000000009017 122.0
PYH1_k127_5123290_6 Ion channel - - - 0.000000000000000000000006447 105.0
PYH1_k127_5166463_0 DEAD DEAH box helicase domain protein K03725 - - 3.656e-195 616.0
PYH1_k127_5166463_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 291.0
PYH1_k127_5192505_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 470.0
PYH1_k127_5192505_1 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 333.0
PYH1_k127_5192505_2 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000004044 218.0
PYH1_k127_5192505_3 PFAM sigma-70 region 4 domain protein K09714 - - 0.0000000000000000000000000000000000000000000000000000000003063 207.0
PYH1_k127_5192505_4 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000004807 120.0
PYH1_k127_5192505_5 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000001786 91.0
PYH1_k127_5199017_0 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 520.0
PYH1_k127_5199017_1 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 381.0
PYH1_k127_5199017_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 303.0
PYH1_k127_5211687_0 Belongs to the MCM family K10726 - - 4.422e-300 934.0
PYH1_k127_5211687_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 477.0
PYH1_k127_5211687_2 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000001126 72.0
PYH1_k127_5216705_0 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 482.0
PYH1_k127_5216705_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 476.0
PYH1_k127_5216705_2 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000000007301 201.0
PYH1_k127_5216705_3 Belongs to the UPF0146 family K09713 - - 0.00000000000000000000000000000000000000000001107 176.0
PYH1_k127_5230038_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 494.0
PYH1_k127_5230038_1 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 436.0
PYH1_k127_5230038_2 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 364.0
PYH1_k127_5230038_3 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000004038 171.0
PYH1_k127_5298062_0 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 398.0
PYH1_k127_5298062_1 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 339.0
PYH1_k127_5298062_2 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002129 285.0
PYH1_k127_5298062_3 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000195 249.0
PYH1_k127_5298062_4 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000002303 109.0
PYH1_k127_5298062_5 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000001252 95.0
PYH1_k127_5334931_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 563.0
PYH1_k127_5334931_1 Putative modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000178 171.0
PYH1_k127_5338630_0 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 362.0
PYH1_k127_5338630_1 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 303.0
PYH1_k127_5338630_2 PFAM Rubrerythrin - - - 0.00000000000000002212 81.0
PYH1_k127_5340038_0 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004052 284.0
PYH1_k127_5340038_1 PFAM peptidase M50 - - - 0.0000000000000000000000007049 106.0
PYH1_k127_5340038_2 PFAM Tetratricopeptide repeat - - - 0.000000006146 66.0
PYH1_k127_5340539_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 365.0
PYH1_k127_5340539_1 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000002852 209.0
PYH1_k127_5349456_0 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 396.0
PYH1_k127_5349456_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 303.0
PYH1_k127_5349456_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000001231 122.0
PYH1_k127_5400697_0 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 494.0
PYH1_k127_5400697_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 362.0
PYH1_k127_5400697_2 Lysine exporter protein LysE YggA - - - 0.0000000000000000000000000000002201 128.0
PYH1_k127_5424773_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 561.0
PYH1_k127_5424773_1 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000000000001322 153.0
PYH1_k127_5427402_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 498.0
PYH1_k127_5427402_1 methanogenesis marker protein 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 417.0
PYH1_k127_5427402_2 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000000000000000000003141 197.0
PYH1_k127_5433505_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 8.938e-198 629.0
PYH1_k127_5433505_1 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000861 567.0
PYH1_k127_5433505_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 475.0
PYH1_k127_5433505_3 PFAM DNA methylase N-4 N-6 domain protein K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 381.0
PYH1_k127_5433505_4 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.00000000000000000000009631 104.0
PYH1_k127_5433505_5 - - - - 0.0000004024 52.0
PYH1_k127_5452475_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 576.0
PYH1_k127_5452475_1 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 528.0
PYH1_k127_5452475_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000003489 165.0
PYH1_k127_5452475_3 - - - - 0.00000000000000000000000000000005919 126.0
PYH1_k127_5452475_4 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000835 50.0
PYH1_k127_5460057_0 Methyltransferase K15256 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001772 256.0
PYH1_k127_5460057_1 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000002234 185.0
PYH1_k127_5460057_2 - - - - 0.0000000000000000000000000000005655 129.0
PYH1_k127_5469250_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 582.0
PYH1_k127_5469250_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 384.0
PYH1_k127_5469250_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000000000000000000000000000000000000000007939 173.0
PYH1_k127_5525147_0 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
PYH1_k127_5525147_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 305.0
PYH1_k127_5525147_2 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.0000000000000000000001208 103.0
PYH1_k127_5525147_3 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000002078 95.0
PYH1_k127_5548076_0 Pectinesterase - - - 0.000000000000000000000000000000000000000009355 171.0
PYH1_k127_5548076_1 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000000007615 97.0
PYH1_k127_5548076_2 Protein kinase domain - - - 0.00000000000000004417 84.0
PYH1_k127_5603486_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 564.0
PYH1_k127_5603486_1 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 375.0
PYH1_k127_5603486_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000312 244.0
PYH1_k127_5603486_3 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000002177 226.0
PYH1_k127_5603486_4 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000002624 182.0
PYH1_k127_5603486_5 - - - - 0.000000000000000000001968 103.0
PYH1_k127_5681996_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 7.535e-246 772.0
PYH1_k127_5693367_0 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 314.0
PYH1_k127_5693367_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000004659 218.0
PYH1_k127_5697572_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 454.0
PYH1_k127_5697572_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 439.0
PYH1_k127_5697572_2 AIR synthase related protein domain protein K04655 - - 0.000000000000000000000000000000000000000000000000000000007969 203.0
PYH1_k127_5697572_3 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000001394 99.0
PYH1_k127_5726662_0 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 540.0
PYH1_k127_5726662_1 Protein of unknown function (DUF4013) - - - 0.000000000000000000000000000000000000000000000000000004547 197.0
PYH1_k127_5751456_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 1.74e-293 916.0
PYH1_k127_5751456_1 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000006284 234.0
PYH1_k127_5751456_2 Protein of unknown function (DUF432) K09149 - - 0.0000000000000000000000000000000000000000000000000008112 192.0
PYH1_k127_5751456_3 - - - - 0.0000000000000000000000000000000000000001299 156.0
PYH1_k127_5751456_4 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000003136 106.0
PYH1_k127_5753068_0 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 388.0
PYH1_k127_5753068_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000008797 209.0
PYH1_k127_5753068_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000001105 72.0
PYH1_k127_5765609_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 566.0
PYH1_k127_5765609_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 525.0
PYH1_k127_5765609_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 497.0
PYH1_k127_5765609_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 434.0
PYH1_k127_5765609_4 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001104 255.0
PYH1_k127_5765609_5 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000003944 195.0
PYH1_k127_5765609_6 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000026 162.0
PYH1_k127_5765609_7 PFAM ADP-ribosylation Crystallin J1 - - - 0.0002177 44.0
PYH1_k127_5788124_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004813 567.0
PYH1_k127_5788124_1 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 411.0
PYH1_k127_5788124_2 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 342.0
PYH1_k127_5788124_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 329.0
PYH1_k127_5788124_4 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000002429 160.0
PYH1_k127_5816992_0 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
PYH1_k127_5816992_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000002105 174.0
PYH1_k127_5816992_2 GyrI-like small molecule binding domain - - - 0.0000000000000000000000000000000000000000000006088 173.0
PYH1_k127_5816992_3 Domain of unknown function (DUF333) K09712 - - 0.0000000000003667 75.0
PYH1_k127_5844948_0 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 512.0
PYH1_k127_5844948_1 O-acyltransferase activity - - - 0.000000000000000000000000000000001709 133.0
PYH1_k127_5866354_0 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000006704 109.0
PYH1_k127_5866354_1 - - - - 0.0000000000000002778 88.0
PYH1_k127_5870271_0 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000009995 174.0
PYH1_k127_5870271_1 membrane - - - 0.000000000000000000003859 104.0
PYH1_k127_5870271_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000018 65.0
PYH1_k127_5889812_0 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 303.0
PYH1_k127_5889812_1 Pfam:KaiC - - - 0.000000000000000000000000000000002821 139.0
PYH1_k127_5889812_2 PFAM type II secretion system protein E K07332 - - 0.000000000000000000000000116 110.0
PYH1_k127_5916897_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 558.0
PYH1_k127_5916897_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 311.0
PYH1_k127_5916897_2 Flavodoxin - - - 0.000000000000000000000000000000000000005192 153.0
PYH1_k127_5959298_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 405.0
PYH1_k127_5959298_1 PFAM ADP-ribosylation Crystallin J1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008282 291.0
PYH1_k127_5985789_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 496.0
PYH1_k127_5985789_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 443.0
PYH1_k127_5985789_2 Membrane protein of unknown function DUF63 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 349.0
PYH1_k127_5985789_3 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000000000000000000000000000323 184.0
PYH1_k127_5986035_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008486 448.0
PYH1_k127_5986035_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000006821 198.0
PYH1_k127_5986035_2 - - - - 0.0000000000000000000000000003546 116.0
PYH1_k127_5987611_0 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004991 362.0
PYH1_k127_5987611_1 PFAM Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000000000000000000000000003912 218.0
PYH1_k127_5987611_2 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000377 70.0
PYH1_k127_6027952_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1035.0
PYH1_k127_6027952_1 SMART Elongator protein 3 MiaB NifB - - - 6.331e-233 732.0
PYH1_k127_6027952_2 phosphoesterase RecJ domain protein - - - 5.894e-199 628.0
PYH1_k127_6027952_3 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 417.0
PYH1_k127_6027952_4 tRNAHis guanylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 305.0
PYH1_k127_6027952_5 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000003249 232.0
PYH1_k127_6027952_6 PFAM PRC-barrel domain - - - 0.000000000000000000000000006607 123.0
PYH1_k127_6030887_0 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001264 246.0
PYH1_k127_6030887_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001703 233.0
PYH1_k127_6030887_2 membrane K09167 - - 0.00000000000000000000000000000000000000000000000000000000001539 212.0
PYH1_k127_6033774_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 389.0
PYH1_k127_6033774_1 Fumarase C-terminus K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000002421 266.0
PYH1_k127_6033774_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.00000000005895 63.0
PYH1_k127_6070407_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 496.0
PYH1_k127_6070407_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 382.0
PYH1_k127_6070573_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 563.0
PYH1_k127_6070573_1 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000000000000000000001799 224.0
PYH1_k127_6070573_2 nucleic acid binding OB-fold tRNA helicase-type - - - 0.0000000000000000000000009479 108.0
PYH1_k127_6070573_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000001039 107.0
PYH1_k127_6070573_4 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000003632 90.0
PYH1_k127_6070573_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000008763 90.0
PYH1_k127_6092443_0 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 378.0
PYH1_k127_6092443_1 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 296.0
PYH1_k127_6092443_2 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008423 255.0
PYH1_k127_6092443_3 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000000002448 174.0
PYH1_k127_6092443_4 Domain of unknown function DUF87 - - - 0.000000000000000000000000000000000000000005052 163.0
PYH1_k127_6092443_5 - - - - 0.000000000006823 71.0
PYH1_k127_6092443_6 - - - - 0.00000009066 61.0
PYH1_k127_6100947_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 449.0
PYH1_k127_6100947_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000002147 214.0
PYH1_k127_6100947_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000002559 87.0
PYH1_k127_6111040_0 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 368.0
PYH1_k127_6111040_1 Belongs to the N(4) N(6)-methyltransferase family K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 361.0
PYH1_k127_6111040_2 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000004027 202.0
PYH1_k127_6111040_3 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000009246 173.0
PYH1_k127_6126267_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 470.0
PYH1_k127_6126267_1 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 425.0
PYH1_k127_6126267_2 PFAM Peptidase M20 K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 402.0
PYH1_k127_6126267_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 360.0
PYH1_k127_6126267_4 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 300.0
PYH1_k127_6126267_5 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000000000000000009887 160.0
PYH1_k127_6126267_6 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000007236 132.0
PYH1_k127_6126267_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000001877 95.0
PYH1_k127_6165988_0 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000001085 269.0
PYH1_k127_6165988_1 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000959 162.0
PYH1_k127_6181935_0 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 525.0
PYH1_k127_6181935_1 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000007297 247.0
PYH1_k127_6181935_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000001443 115.0
PYH1_k127_6183599_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 293.0
PYH1_k127_6183599_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009559 241.0
PYH1_k127_6183599_2 DUF167 K09131 - - 0.00000004434 59.0
PYH1_k127_6187462_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 464.0
PYH1_k127_6187462_1 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 437.0
PYH1_k127_6187462_2 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 336.0
PYH1_k127_6187462_3 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000000001131 166.0
PYH1_k127_6187462_4 PDGLE domain K02009 - - 0.0000000000000000000000000000000000004387 148.0
PYH1_k127_6187462_5 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000003104 71.0
PYH1_k127_6234670_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 533.0
PYH1_k127_6234670_1 amidohydrolase - - - 0.00000000000000000000000000003552 119.0
PYH1_k127_6250236_0 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 481.0
PYH1_k127_6250236_1 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 285.0
PYH1_k127_6265674_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009093 428.0
PYH1_k127_6265674_1 RimK domain protein ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 379.0
PYH1_k127_6265674_2 PFAM HhH-GPD family protein K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005605 317.0
PYH1_k127_6265674_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005291 252.0
PYH1_k127_6265674_4 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000007041 104.0
PYH1_k127_6366907_0 COG0589 Universal stress protein UspA and related nucleotide-binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000004551 214.0
PYH1_k127_6366907_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000006734 205.0
PYH1_k127_6366907_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000007426 97.0
PYH1_k127_6366907_3 Protein of unknown function (DUF2764) - - - 0.000000000000000002895 91.0
PYH1_k127_6420018_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 531.0
PYH1_k127_6420018_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 456.0
PYH1_k127_6420018_2 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000001021 210.0
PYH1_k127_6420018_3 - - - - 0.00000000000000003237 82.0
PYH1_k127_6445888_0 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 334.0
PYH1_k127_6445888_1 amino acid K03294 - - 0.0000000000000000000000000000000002037 138.0
PYH1_k127_6450048_0 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 465.0
PYH1_k127_6450048_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 304.0
PYH1_k127_6450048_2 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001616 270.0
PYH1_k127_6450048_3 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000007069 205.0
PYH1_k127_6450048_4 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000002569 143.0
PYH1_k127_6450048_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000001056 119.0
PYH1_k127_6450048_6 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000001005 82.0
PYH1_k127_6450048_7 CRS1_YhbY K07574 - - 0.0000000000000004844 79.0
PYH1_k127_6450048_8 structural constituent of ribosome K02924 - - 0.00000000002788 70.0
PYH1_k127_645788_0 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000000000000000000000000000000000000000000000005371 228.0
PYH1_k127_645788_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000002538 156.0
PYH1_k127_645788_2 Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin K05710,K14750,K18087,K18089 GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016054,GO:0016999,GO:0017001,GO:0017144,GO:0018962,GO:0019380,GO:0019439,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000002923 92.0
PYH1_k127_651077_0 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005318 265.0
PYH1_k127_651077_1 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000000000000000000000000000003095 175.0
PYH1_k127_651077_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000004602 90.0
PYH1_k127_6545704_0 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008454 377.0
PYH1_k127_6545704_1 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 313.0
PYH1_k127_6545704_2 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002155 280.0
PYH1_k127_6561142_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 362.0
PYH1_k127_6561142_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 282.0
PYH1_k127_6561142_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000002906 121.0
PYH1_k127_6577997_0 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 374.0
PYH1_k127_6577997_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000000005201 147.0
PYH1_k127_6577997_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000001064 96.0
PYH1_k127_6625529_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 460.0
PYH1_k127_6625529_1 - - - - 0.00000000000005328 73.0
PYH1_k127_6625529_3 endonuclease K07451 - - 0.0008324 47.0
PYH1_k127_6628901_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 7.479e-228 713.0
PYH1_k127_6634673_0 PFAM ABC transporter K00400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 522.0
PYH1_k127_6634673_1 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 323.0
PYH1_k127_6634673_2 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000001441 102.0
PYH1_k127_6682884_0 Helix-turn-helix domain protein K07731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 359.0
PYH1_k127_6682884_1 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000006728 170.0
PYH1_k127_6682884_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000004619 139.0
PYH1_k127_6690444_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000089 475.0
PYH1_k127_6690444_1 Domain of unknown function (DUF1848) - - - 0.00000000000000000000000002545 112.0
PYH1_k127_6719891_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1067.0
PYH1_k127_6719891_1 DEAD DEAH box helicase domain protein K10896 - - 1.15e-213 677.0
PYH1_k127_6719891_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 5.86e-196 617.0
PYH1_k127_6719891_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000001672 206.0
PYH1_k127_6719891_4 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000000000000001638 146.0
PYH1_k127_6719891_5 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.0000000000000004801 84.0
PYH1_k127_6749074_0 Heat shock 70 kDa protein K04043 - - 3.843e-285 884.0
PYH1_k127_6749074_1 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000008386 235.0
PYH1_k127_6749074_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000998 165.0
PYH1_k127_6752376_0 ATP synthase alpha/beta family, beta-barrel domain K02118 - - 1.167e-211 664.0
PYH1_k127_6752376_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 404.0
PYH1_k127_6752376_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000006226 105.0
PYH1_k127_6776213_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1.656e-318 984.0
PYH1_k127_6776213_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 432.0
PYH1_k127_6783166_0 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 427.0
PYH1_k127_6783166_1 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 432.0
PYH1_k127_6783166_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003023 267.0
PYH1_k127_6783166_3 - - - - 0.00000000000000000000000002904 113.0
PYH1_k127_6797916_0 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 364.0
PYH1_k127_6797916_1 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000004296 147.0
PYH1_k127_6800269_0 Belongs to the glutamate synthase family - - - 3.71e-276 856.0
PYH1_k127_6800269_1 PFAM glutamine amidotransferase, class-II - - - 0.000004785 48.0
PYH1_k127_6813064_0 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 321.0
PYH1_k127_6813064_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 308.0
PYH1_k127_6813064_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005924 284.0
PYH1_k127_6815562_0 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000001035 203.0
PYH1_k127_6815562_1 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.00000000000000000000000000000000000000000000004676 185.0
PYH1_k127_6815562_2 metallopeptidase activity - - - 0.0000000000000001148 88.0
PYH1_k127_6815562_3 Protein of unknown function (DUF998) - - - 0.0000000000009393 77.0
PYH1_k127_6819573_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002431 276.0
PYH1_k127_6819573_1 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007527 267.0
PYH1_k127_6819573_2 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006244 244.0
PYH1_k127_6819573_3 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000002787 195.0
PYH1_k127_6819573_4 PFAM SCP-like extracellular - - - 0.00000000000000000000000000000000003031 144.0
PYH1_k127_6819573_5 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000000002583 115.0
PYH1_k127_6819573_6 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000005467 86.0
PYH1_k127_6824428_0 PFAM ABC transporter K00400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 404.0
PYH1_k127_6824428_1 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 412.0
PYH1_k127_6851073_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002089 274.0
PYH1_k127_6851073_1 - - - - 0.00000000000000000000000000000000000000000002477 172.0
PYH1_k127_6851073_2 PFAM cyclase family protein K07130 - 3.5.1.9 0.0000000000000000000000001384 108.0
PYH1_k127_6868228_0 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001261 276.0
PYH1_k127_6868228_1 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000001194 227.0
PYH1_k127_6868228_2 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000008217 171.0
PYH1_k127_6868228_3 - - - - 0.0000000009625 63.0
PYH1_k127_6876956_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 466.0
PYH1_k127_6876956_1 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 316.0
PYH1_k127_6876956_2 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000686 303.0
PYH1_k127_6876956_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000003839 168.0
PYH1_k127_6876956_4 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000003679 145.0
PYH1_k127_6950794_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 559.0
PYH1_k127_6950794_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 319.0
PYH1_k127_6950794_2 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000001663 199.0
PYH1_k127_6961145_0 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007844 542.0
PYH1_k127_6961145_1 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 401.0
PYH1_k127_6961145_2 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000005054 189.0
PYH1_k127_6980397_0 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 418.0
PYH1_k127_6980397_1 PFAM Radical SAM domain protein K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 408.0
PYH1_k127_6982864_0 AAA-like domain K06915 - - 1.382e-216 685.0
PYH1_k127_6982864_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006513 254.0
PYH1_k127_6984918_0 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.0000000000000000000000000000000000000000000000000000000000000000008474 241.0
PYH1_k127_6984918_1 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000000000000000002208 235.0
PYH1_k127_6984918_2 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000001454 190.0
PYH1_k127_6984918_3 PFAM BioY protein K03523 - - 0.0000000000000000000000000000005502 124.0
PYH1_k127_7004633_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008554 289.0
PYH1_k127_7004633_1 PFAM Ribonuclease III K03685 - 3.1.26.3 0.000000000000000000000000000485 118.0
PYH1_k127_7004633_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000002873 85.0
PYH1_k127_7013537_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 451.0
PYH1_k127_7013537_1 TIGRFAM PAS sensor protein - - - 0.0000000000000000000000000000000000000000004327 163.0
PYH1_k127_7024481_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.309e-289 896.0
PYH1_k127_7024481_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000001814 251.0
PYH1_k127_7024481_2 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000006474 180.0
PYH1_k127_7024481_3 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.00000000000000000000000000648 110.0
PYH1_k127_7047514_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 445.0
PYH1_k127_7047514_1 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005241 272.0
PYH1_k127_7047514_2 membrane K09167 - - 0.000000000000000000000000000004574 123.0
PYH1_k127_7067965_0 Ferrous iron transport B domain protein K04759 - - 1.648e-214 689.0
PYH1_k127_7067965_1 iron dependent repressor K03709,K04758 - - 0.00000000000000000000000000000007783 128.0
PYH1_k127_7067965_2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000004197 79.0
PYH1_k127_7074351_0 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000001395 241.0
PYH1_k127_7074351_1 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000003028 130.0
PYH1_k127_7074351_2 PFAM Telomeric repeat-binding factor 2 - - - 0.000000000000000006029 94.0
PYH1_k127_7074351_3 PFAM Telomeric repeat-binding factor 2 - - - 0.00000000000000001177 92.0
PYH1_k127_7074351_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000229 68.0
PYH1_k127_7085236_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000402 248.0
PYH1_k127_7085236_1 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000001877 239.0
PYH1_k127_7085236_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000002265 64.0
PYH1_k127_7089738_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 4.933e-296 915.0
PYH1_k127_7089738_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 364.0
PYH1_k127_7089738_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000001094 171.0
PYH1_k127_7089738_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000001429 72.0
PYH1_k127_711267_0 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 430.0
PYH1_k127_711267_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002583 274.0
PYH1_k127_711267_2 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000001387 197.0
PYH1_k127_711267_3 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000018 165.0
PYH1_k127_7135315_0 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 602.0
PYH1_k127_7135315_1 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.00000000000005085 72.0
PYH1_k127_7137041_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 608.0
PYH1_k127_7137041_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 598.0
PYH1_k127_7141352_0 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 507.0
PYH1_k127_7141352_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 331.0
PYH1_k127_7141352_2 Pas domain - - - 0.0000000000000000000000000000000000000000000000000000000000001601 229.0
PYH1_k127_7141352_3 Flavodoxin - - - 0.000000000000000000000000000000000000000000000001387 178.0
PYH1_k127_7141352_5 metallopeptidase activity - - - 0.000000000000000000000000008211 122.0
PYH1_k127_7141352_6 PFAM TPR repeat-containing protein - - - 0.000000000005727 74.0
PYH1_k127_7141352_7 TIR domain - - - 0.00000008388 60.0
PYH1_k127_7196313_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 564.0
PYH1_k127_7196313_1 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 338.0
PYH1_k127_7196313_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000002585 254.0
PYH1_k127_7196313_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000714 225.0
PYH1_k127_7196313_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000001657 157.0
PYH1_k127_7196313_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000195 86.0
PYH1_k127_7202664_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 339.0
PYH1_k127_7202664_1 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000005212 98.0
PYH1_k127_7223485_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 4.873e-215 672.0
PYH1_k127_7223485_1 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000054 232.0
PYH1_k127_7265679_0 PFAM ferredoxin-dependent glutamate synthase - - - 2.653e-284 882.0
PYH1_k127_7265679_1 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000002894 266.0
PYH1_k127_7265679_2 - - - - 0.00000000000000000000000000000000000000000000000000005995 203.0
PYH1_k127_7265679_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000004984 74.0
PYH1_k127_7265679_4 TIR domain - - - 0.000000000001039 75.0
PYH1_k127_7267047_0 archaeal Zn-finger protein - - - 0.0000000000000000000000000000000000000000000000000000000000003369 216.0
PYH1_k127_7267047_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000008272 149.0
PYH1_k127_7267047_2 - - - - 0.000000000000000000000000000006465 127.0
PYH1_k127_7267047_3 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000003164 104.0
PYH1_k127_7267047_4 Domain of unknown function (DUF371) K09738 - - 0.00000000000000004189 87.0
PYH1_k127_7270246_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 362.0
PYH1_k127_7270246_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000002277 259.0
PYH1_k127_7270246_2 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000001058 206.0
PYH1_k127_7310663_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 313.0
PYH1_k127_7310663_1 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000006477 235.0
PYH1_k127_7310663_10 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000000000001148 108.0
PYH1_k127_7310663_11 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000005135 99.0
PYH1_k127_7310663_12 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000000006714 99.0
PYH1_k127_7310663_13 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000274 96.0
PYH1_k127_7310663_14 Binds the lower part of the 30S subunit head K02982 - - 0.0000001256 55.0
PYH1_k127_7310663_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000000001273 233.0
PYH1_k127_7310663_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000009056 229.0
PYH1_k127_7310663_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000006975 225.0
PYH1_k127_7310663_5 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000000000000007842 214.0
PYH1_k127_7310663_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000003595 213.0
PYH1_k127_7310663_7 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000000000000000007157 184.0
PYH1_k127_7310663_8 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.000000000000000000000000000000000000003242 149.0
PYH1_k127_7310663_9 PFAM Ribosomal protein K02912 - - 0.0000000000000000000000000000000235 132.0
PYH1_k127_7341317_0 PFAM amino acid-binding ACT domain protein K06862 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006044 244.0
PYH1_k127_7341317_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000005738 244.0
PYH1_k127_7341317_2 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008206 245.0
PYH1_k127_7349540_0 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004911 280.0
PYH1_k127_7349540_1 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000105 235.0
PYH1_k127_7349540_2 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000002621 214.0
PYH1_k127_7420567_0 in RNase L inhibitor, RLI K06174 - - 6.395e-203 640.0
PYH1_k127_745975_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 340.0
PYH1_k127_745975_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000002614 237.0
PYH1_k127_745975_2 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000943 233.0
PYH1_k127_745975_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000481 102.0
PYH1_k127_7468942_0 PFAM peptidase K07386 - - 1.913e-194 635.0
PYH1_k127_7468942_1 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 345.0
PYH1_k127_7472196_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 337.0
PYH1_k127_7472196_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000004357 226.0
PYH1_k127_7500304_0 SMART zinc finger, CDGSH-type domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009157 265.0
PYH1_k127_7500304_1 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000005788 173.0
PYH1_k127_7500304_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000001421 158.0
PYH1_k127_7500304_3 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000000000000000003008 147.0
PYH1_k127_7500304_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000002395 79.0
PYH1_k127_7520811_0 Carbamoyltransferase C-terminus K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 471.0
PYH1_k127_7520811_3 amidohydrolase - - - 0.00000000000000000000184 96.0
PYH1_k127_7526388_0 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000001188 191.0
PYH1_k127_7526388_1 - - - - 0.0000000000000000000000000000000000000000000002037 175.0
PYH1_k127_7529798_0 Helix-hairpin-helix domain K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 491.0
PYH1_k127_7529798_1 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 383.0
PYH1_k127_7529798_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 359.0
PYH1_k127_7529798_3 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 285.0
PYH1_k127_7529798_4 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000005778 263.0
PYH1_k127_7538988_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 3.724e-204 646.0
PYH1_k127_7538988_1 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 526.0
PYH1_k127_7538988_2 Roadblock LC7 K07131 - - 0.0000000000000000000000000000000000000000000000004617 177.0
PYH1_k127_7546327_0 PFAM Thiolase K00626 - 2.3.1.9 2.891e-207 649.0
PYH1_k127_7546327_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 465.0
PYH1_k127_7546327_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000008587 142.0
PYH1_k127_7561527_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.2e-229 719.0
PYH1_k127_7561527_1 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 362.0
PYH1_k127_7561527_2 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007522 282.0
PYH1_k127_7561527_3 ribosomal protein S15 K02956 - - 0.000000000000000000000000000000000000000000000000000000000000000903 221.0
PYH1_k127_7561527_4 - - - - 0.00000003376 61.0
PYH1_k127_7574376_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 7.416e-207 657.0
PYH1_k127_7574922_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 4.328e-197 619.0
PYH1_k127_7574922_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000003852 166.0
PYH1_k127_7597239_0 PFAM NAD dependent epimerase dehydratase family K01709,K01710,K01784 - 4.2.1.45,4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000792 396.0
PYH1_k127_7597239_1 PFAM transferase hexapeptide repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001919 257.0
PYH1_k127_7597239_2 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000005353 130.0
PYH1_k127_7605493_0 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 536.0
PYH1_k127_7605493_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000001959 125.0
PYH1_k127_7608238_0 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 454.0
PYH1_k127_7608238_1 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008854 319.0
PYH1_k127_7608238_2 Transcriptional regulator K07108 - - 0.00000000000000009103 85.0
PYH1_k127_7608238_3 Transcriptional regulator K07108 - - 0.00009347 49.0
PYH1_k127_7633676_0 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 301.0
PYH1_k127_7633676_1 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000006419 177.0
PYH1_k127_7633676_2 PFAM PEGA domain - - - 0.00000000000000000000003572 104.0
PYH1_k127_7667310_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 3.873e-273 855.0
PYH1_k127_7667310_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000007041 262.0
PYH1_k127_7667310_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000002785 138.0
PYH1_k127_7667310_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0003686 53.0
PYH1_k127_7678171_0 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 406.0
PYH1_k127_7686161_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 293.0
PYH1_k127_7686161_1 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000002127 268.0
PYH1_k127_7686161_2 signal transduction protein with CBS domains K07744 - - 0.00000000000000127 80.0
PYH1_k127_7686161_3 PRC-barrel domain - - - 0.0000000000003125 73.0
PYH1_k127_7703647_0 PFAM type II secretion system protein E K07332 - - 5.53e-284 902.0
PYH1_k127_7703647_1 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002835 258.0
PYH1_k127_7717763_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 596.0
PYH1_k127_7717763_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000002456 72.0
PYH1_k127_7726728_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 558.0
PYH1_k127_7726728_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 372.0
PYH1_k127_7726728_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000001728 147.0
PYH1_k127_7740985_0 domain, Protein K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007702 542.0
PYH1_k127_7740985_1 Sulphur transport K07112 - - 0.00000000000000000000000000001094 119.0
PYH1_k127_7740985_2 iron dependent repressor K03709 - - 0.000000000000000000000000002071 114.0
PYH1_k127_7747439_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 346.0
PYH1_k127_7747439_1 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003284 229.0
PYH1_k127_7787631_0 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000002015 224.0
PYH1_k127_7787631_1 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000285 177.0
PYH1_k127_7787631_2 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000000000004063 145.0
PYH1_k127_7787631_3 - K00960 - 2.7.7.6 0.000000000000000000000000001194 115.0
PYH1_k127_7787631_4 Tetratricopeptide repeat - - - 0.000000000000000000002144 101.0
PYH1_k127_7787631_5 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07324,K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000007459 71.0
PYH1_k127_7789442_0 PFAM Roadblock LC7 family protein - - - 0.00000000000000000000000000000001075 142.0
PYH1_k127_7789442_1 - - - - 0.0000009108 60.0
PYH1_k127_7803588_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007654 252.0
PYH1_k127_7803588_1 PFAM Abortive infection protein - - - 0.00000000000003435 83.0
PYH1_k127_7803588_2 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.0000001787 63.0
PYH1_k127_7818511_0 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 392.0
PYH1_k127_7818511_1 SpoVT / AbrB like domain - - - 0.0000000000000000000000009479 108.0
PYH1_k127_7825860_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 2.427e-260 809.0
PYH1_k127_7825860_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 425.0
PYH1_k127_7825860_2 - - - - 0.00000000000000000000001163 103.0
PYH1_k127_7825860_3 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00009016 44.0
PYH1_k127_7828384_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 460.0
PYH1_k127_7828384_1 transferase hexapeptide repeat - - - 0.00000000000000000000000000000000000001088 147.0
PYH1_k127_7828384_2 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000356 100.0
PYH1_k127_7897634_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 289.0
PYH1_k127_7897634_1 Phosphate transport regulator K07220 - - 0.0000000000000000000000000008781 115.0
PYH1_k127_7930127_0 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 312.0
PYH1_k127_7930127_1 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 301.0
PYH1_k127_7930127_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003459 253.0
PYH1_k127_7930127_3 Yip1 domain - - - 0.0000000000006878 70.0
PYH1_k127_7948549_0 TIGRFAM MIP family channel K02440,K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 293.0
PYH1_k127_7948549_1 PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002974 237.0
PYH1_k127_7948549_2 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000005409 187.0
PYH1_k127_7948549_3 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000001271 168.0
PYH1_k127_7948549_4 N-6 DNA Methylase - - - 0.0000000000000000000000000000000000000001052 160.0
PYH1_k127_7961870_0 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.0000000000000000000000000000000000000000000000000000000000005257 218.0
PYH1_k127_7961870_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000003258 167.0
PYH1_k127_7975857_0 COG1233 Phytoene dehydrogenase and related proteins K10027,K20611 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37 1.526e-206 653.0
PYH1_k127_7975857_1 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.0000000000503 70.0
PYH1_k127_8016276_0 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 442.0
PYH1_k127_8016276_1 PFAM ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 366.0
PYH1_k127_8016276_2 PFAM SufBD protein K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 321.0
PYH1_k127_8027272_0 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006871 263.0
PYH1_k127_8027272_1 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000000000000002358 133.0
PYH1_k127_8027272_2 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000003999 136.0
PYH1_k127_8027272_3 structural constituent of ribosome K02924 - - 0.00000000000009058 70.0
PYH1_k127_8027272_4 PFAM Ribosomal LX protein K02944 - - 0.0000000003092 62.0
PYH1_k127_8089790_0 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 5.048e-194 611.0
PYH1_k127_8089790_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 458.0
PYH1_k127_8089790_2 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000001033 133.0
PYH1_k127_8089790_3 - - - - 0.000000000000000000000002086 105.0
PYH1_k127_8089790_4 PFAM CBS domain containing protein - - - 0.000000000000000001651 85.0
PYH1_k127_8115565_0 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 398.0
PYH1_k127_8115565_1 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000001321 200.0
PYH1_k127_8115565_2 - - - - 0.0000009366 51.0
PYH1_k127_8115565_3 PFAM BioY protein K03523 - - 0.00001778 53.0
PYH1_k127_8153145_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1320.0
PYH1_k127_8153145_1 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 351.0
PYH1_k127_8153145_2 PFAM PilT protein domain protein K06865 - - 0.0000000000000000000000000000000000000000000000000000000000000002357 224.0
PYH1_k127_8153145_3 - - - - 0.000000000000000000000000000001434 123.0
PYH1_k127_8187787_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 538.0
PYH1_k127_8187787_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 313.0
PYH1_k127_8249167_0 Cytidylyltransferase K07257 - - 0.000000000000000000000000000000000000000000000001952 184.0
PYH1_k127_8249167_1 glucosylceramidase activity - - - 0.00000000000000000000000000000005752 128.0
PYH1_k127_8249167_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000651 62.0
PYH1_k127_8249167_3 Alpha/beta hydrolase family - - - 0.0000002778 52.0
PYH1_k127_8283746_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 342.0
PYH1_k127_8283746_1 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000001268 224.0
PYH1_k127_8283746_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000001478 218.0
PYH1_k127_8283746_3 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000002324 135.0
PYH1_k127_8283746_4 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000001135 64.0
PYH1_k127_830197_0 PFAM CBS domain - - - 3.599e-237 742.0
PYH1_k127_830197_1 NIF3 (NGG1p interacting factor 3) - - - 0.0000000002666 70.0
PYH1_k127_830197_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000002027 61.0
PYH1_k127_850917_0 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 286.0
PYH1_k127_850917_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004183 273.0
PYH1_k127_865942_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 464.0
PYH1_k127_865942_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 440.0
PYH1_k127_865942_2 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 385.0
PYH1_k127_865942_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 337.0
PYH1_k127_865942_4 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000104 257.0
PYH1_k127_865942_5 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000003223 147.0
PYH1_k127_874412_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 496.0
PYH1_k127_874412_1 Domain of unknown function DUF87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 425.0
PYH1_k127_877390_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 514.0
PYH1_k127_877390_1 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000001291 162.0
PYH1_k127_877390_2 PFAM peptidase U32 K08303 - - 0.0000000000000000134 86.0
PYH1_k127_88989_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 373.0
PYH1_k127_88989_1 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000000000000000003567 216.0
PYH1_k127_88989_2 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000000009303 125.0
PYH1_k127_88989_3 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000005187 129.0
PYH1_k127_88989_4 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000009325 89.0
PYH1_k127_890952_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 437.0
PYH1_k127_890952_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 367.0
PYH1_k127_890952_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000002038 166.0
PYH1_k127_9390_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000008016 226.0
PYH1_k127_9390_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000237 159.0
PYH1_k127_9390_2 - - - - 0.00000000000000000000000000000007955 133.0
PYH1_k127_9390_3 Trm112p-like protein - - - 0.00000000000000000003706 96.0
PYH1_k127_950143_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 432.0
PYH1_k127_950143_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 339.0
PYH1_k127_950143_2 TIGRFAM methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001684 254.0
PYH1_k127_950143_3 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000001162 230.0
PYH1_k127_950143_4 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000007592 148.0
PYH1_k127_950143_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000003402 96.0
PYH1_k127_950143_6 Protein of unknown function (DUF4013) - - - 0.00000000008905 68.0
PYH1_k127_971927_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 419.0
PYH1_k127_971927_1 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000007246 220.0
PYH1_k127_971927_2 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000002575 188.0
PYH1_k127_971927_3 Protein tyrosine kinase - - - 0.0000004908 62.0
PYH1_k127_974924_0 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000017 271.0
PYH1_k127_974924_1 Stage II sporulation protein M - - - 0.00000000000000000000000000000000000000002723 162.0
PYH1_k127_981834_0 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 322.0
PYH1_k127_981834_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000001223 231.0
PYH1_k127_981834_2 Tetratricopeptide repeat - - - 0.000000000000000000104 94.0
PYH1_k127_998538_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 529.0
PYH1_k127_998538_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000001832 254.0