Overview

ID MAG03146
Name PYH1_bin.39
Sample SMP0073
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Bathyarchaeia
Order 40CM-2-53-6
Family RBG-13-38-9
Genus JAPKYM01
Species
Assembly information
Completeness (%) 73.85
Contamination (%) 1.29
GC content (%) 47.0
N50 (bp) 11,675
Genome size (bp) 1,200,372

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1138

Gene name Description KEGG GOs EC E-value Score Sequence
PYH1_k127_1009869_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 340.0
PYH1_k127_1009869_1 PFAM Nitrate reductase gamma subunit - - - 0.000000000000000000000000000000008582 136.0
PYH1_k127_1009869_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.000000000000000001126 87.0
PYH1_k127_1123843_0 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 409.0
PYH1_k127_1123843_1 PFAM ABC transporter related K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 357.0
PYH1_k127_1123843_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 353.0
PYH1_k127_1123843_3 PFAM ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 317.0
PYH1_k127_1123843_4 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006078 286.0
PYH1_k127_1123843_5 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.000000000000000000000000000000000000000000000000000000000000000000000000000009956 274.0
PYH1_k127_1123843_6 Peptidase family M48 - - - 0.00000000000000000000001034 112.0
PYH1_k127_1123843_7 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000005376 74.0
PYH1_k127_1125150_0 Heat shock 70 kDa protein K04043 - - 7.509e-218 683.0
PYH1_k127_1125150_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 445.0
PYH1_k127_1125150_10 Transcription elongation factor - - - 0.00000000000000000000001356 106.0
PYH1_k127_1125150_11 cytochrome c biogenesis protein K06196 - - 0.0000000000000000227 90.0
PYH1_k127_1125150_12 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000008223 66.0
PYH1_k127_1125150_13 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000001807 55.0
PYH1_k127_1125150_14 Conserved protein implicated in secretion - - - 0.00006941 51.0
PYH1_k127_1125150_15 acid phosphatase activity - - - 0.0002965 53.0
PYH1_k127_1125150_2 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 391.0
PYH1_k127_1125150_3 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 394.0
PYH1_k127_1125150_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 302.0
PYH1_k127_1125150_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000002035 220.0
PYH1_k127_1125150_6 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000001251 217.0
PYH1_k127_1125150_7 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000001654 158.0
PYH1_k127_1125150_8 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000001024 129.0
PYH1_k127_1125150_9 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000001 114.0
PYH1_k127_1205044_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 441.0
PYH1_k127_1205044_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17870 - 1.6.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 366.0
PYH1_k127_1205044_2 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009877 299.0
PYH1_k127_1205044_3 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000006168 243.0
PYH1_k127_1205044_4 Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000004789 226.0
PYH1_k127_1205044_5 CobQ CobB MinD ParA nucleotide binding domain K07321 - - 0.00000000000000000000000000000000000000000000000002925 188.0
PYH1_k127_1205044_6 Belongs to the ParB family K03497 GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 - 0.0000000000000000000000004941 116.0
PYH1_k127_1205044_7 PFAM regulatory protein AsnC Lrp family - - - 0.0000000000000000000003354 97.0
PYH1_k127_1220290_0 O-methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000004723 159.0
PYH1_k127_1220290_1 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000000000000004595 139.0
PYH1_k127_1220290_2 Cupin domain - - - 0.0000000000009285 72.0
PYH1_k127_1220290_3 - - - - 0.000003044 58.0
PYH1_k127_1249539_0 small GTP-binding protein K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 436.0
PYH1_k127_1249539_1 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 294.0
PYH1_k127_1249539_10 conserved protein, contains double-stranded beta-helix domain - - - 0.000000000000000002171 89.0
PYH1_k127_1249539_2 Exonuclease RNase T and DNA polymerase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000002527 239.0
PYH1_k127_1249539_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008578 239.0
PYH1_k127_1249539_4 flavin reductase - - - 0.000000000000000000000000000000000000000000000000000000000003839 213.0
PYH1_k127_1249539_5 PFAM Appr-1-p processing - - - 0.00000000000000000000000000000000000000000000000000000000002304 212.0
PYH1_k127_1249539_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000007796 174.0
PYH1_k127_1249539_7 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000000204 161.0
PYH1_k127_1249539_8 PFAM Rhomboid family protein K07059 - - 0.0000000000000000000000000000000001142 140.0
PYH1_k127_1249539_9 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000001082 128.0
PYH1_k127_132943_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009766 327.0
PYH1_k127_132943_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.00000000000000000000000000000000000000000000000001955 189.0
PYH1_k127_1382216_0 Domain of unknown function (DUF814) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 375.0
PYH1_k127_1382216_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 343.0
PYH1_k127_1382216_2 reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000001261 237.0
PYH1_k127_1382216_3 serine-type endopeptidase activity K00505,K01342,K02035 - 1.14.18.1,3.4.21.62 0.00000000000000000000000000006354 126.0
PYH1_k127_1382216_4 PFAM CBS domain containing protein - - - 0.0000000000003546 73.0
PYH1_k127_1382216_5 - - - - 0.000005854 55.0
PYH1_k127_1442656_0 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000007388 243.0
PYH1_k127_1472579_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 418.0
PYH1_k127_1472579_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 329.0
PYH1_k127_1472579_2 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000001601 213.0
PYH1_k127_1477066_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 325.0
PYH1_k127_1477066_1 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001053 272.0
PYH1_k127_1477066_10 Winged helix-turn-helix - - - 0.0000000000000000000000000000000001085 135.0
PYH1_k127_1477066_11 tRNA 3'-trailer cleavage - - - 0.00000000006714 64.0
PYH1_k127_1477066_12 COG0517 FOG CBS domain - - - 0.000000005684 68.0
PYH1_k127_1477066_13 M6 family metalloprotease domain protein - - - 0.00000008112 64.0
PYH1_k127_1477066_14 Peptidase C13 family - - - 0.000004691 59.0
PYH1_k127_1477066_2 Related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000004583 247.0
PYH1_k127_1477066_3 Belongs to the ABC transporter superfamily K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008481 253.0
PYH1_k127_1477066_4 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000004065 242.0
PYH1_k127_1477066_5 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000004102 243.0
PYH1_k127_1477066_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000001091 215.0
PYH1_k127_1477066_7 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000008844 198.0
PYH1_k127_1477066_8 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000002549 160.0
PYH1_k127_1477066_9 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000001442 158.0
PYH1_k127_1494461_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 456.0
PYH1_k127_1494461_1 AAA-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 340.0
PYH1_k127_1494461_2 Binds to RNA in loop regions with AU-rich sequences K22469 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.0000000001248 69.0
PYH1_k127_1494461_3 Binds to RNA in loop regions with AU-rich sequences K22469 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.000357 50.0
PYH1_k127_1503730_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 342.0
PYH1_k127_1503730_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000247 292.0
PYH1_k127_1503730_2 Phosphoribosyl transferase domain K00759,K09685 - 2.4.2.7 0.000000000000000000000000000009013 123.0
PYH1_k127_1503730_3 transcriptional - - - 0.0000000000000000000000000103 113.0
PYH1_k127_1503730_4 Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.00000000000000000004595 97.0
PYH1_k127_1503730_5 - - - - 0.0000000000002695 73.0
PYH1_k127_1521167_0 PFAM FAD dependent oxidoreductase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 579.0
PYH1_k127_1521167_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 432.0
PYH1_k127_1521167_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 322.0
PYH1_k127_1521167_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000001518 172.0
PYH1_k127_1521167_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000002024 92.0
PYH1_k127_1523327_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 546.0
PYH1_k127_1523327_1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 374.0
PYH1_k127_1523327_2 integral membrane protein K00728 - 2.4.1.109 0.000000005649 68.0
PYH1_k127_1541533_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 592.0
PYH1_k127_1541533_1 serine acetyltransferase K00640 GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000005457 259.0
PYH1_k127_1541533_2 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000001815 231.0
PYH1_k127_1541533_3 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000003498 198.0
PYH1_k127_1541533_4 ACT domain - - - 0.000000000000000001512 91.0
PYH1_k127_1541533_5 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.000000000000001428 84.0
PYH1_k127_1591510_0 metallo-beta-lactamase K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 405.0
PYH1_k127_1591510_1 TIGRFAM DNA helicase - - - 0.0000000000000000000000000000000000000000000000000000008317 219.0
PYH1_k127_1591510_2 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000001784 119.0
PYH1_k127_1591510_3 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000161 102.0
PYH1_k127_1591510_4 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000003496 88.0
PYH1_k127_1592104_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1652.0
PYH1_k127_1592104_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1425.0
PYH1_k127_1592104_10 required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 374.0
PYH1_k127_1592104_11 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 309.0
PYH1_k127_1592104_12 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 294.0
PYH1_k127_1592104_13 PFAM Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002034 287.0
PYH1_k127_1592104_14 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000002359 271.0
PYH1_k127_1592104_15 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001458 248.0
PYH1_k127_1592104_16 transferase hexapeptide repeat containing protein K00966,K16881 - 2.7.7.13,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000003127 231.0
PYH1_k127_1592104_17 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000008721 195.0
PYH1_k127_1592104_18 Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000001254 203.0
PYH1_k127_1592104_19 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000008515 202.0
PYH1_k127_1592104_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 1302.0
PYH1_k127_1592104_20 - - - - 0.0000000000000000000000000000000000000000000002833 176.0
PYH1_k127_1592104_21 TIGRFAM cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000005432 178.0
PYH1_k127_1592104_22 Participates in transcription termination K02600 - - 0.000000000000000000000000000000000000001783 151.0
PYH1_k127_1592104_24 PFAM Glycosyl transferase family 4 K01001 - 2.7.8.15 0.000000000000000000000000000000000001438 151.0
PYH1_k127_1592104_25 NIPSNAP - - - 0.000000000000000000000000000000001195 132.0
PYH1_k127_1592104_26 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000002278 127.0
PYH1_k127_1592104_27 Trm112p-like protein - - - 0.000000000000000000000000006593 111.0
PYH1_k127_1592104_28 Belongs to the SfsA family K01892,K06206 - 6.1.1.21 0.000000000000000000000269 102.0
PYH1_k127_1592104_29 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000005576 97.0
PYH1_k127_1592104_3 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1056.0
PYH1_k127_1592104_30 Belongs to the eukaryotic ribosomal protein eL30 family K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000003445 96.0
PYH1_k127_1592104_31 Sugar-specific transcriptional regulator TrmB - - - 0.000000000000000006435 95.0
PYH1_k127_1592104_32 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000001519 80.0
PYH1_k127_1592104_33 Uncharacterised MFS-type transporter YbfB K05548 - - 0.0000000000002448 82.0
PYH1_k127_1592104_34 YHS domain - - - 0.0000000000002624 70.0
PYH1_k127_1592104_35 QueT transporter - - - 0.000000001067 66.0
PYH1_k127_1592104_36 transcriptional - - - 0.0000002213 62.0
PYH1_k127_1592104_37 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.000005548 51.0
PYH1_k127_1592104_38 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000131 56.0
PYH1_k127_1592104_39 RHS Repeat - - - 0.00004753 55.0
PYH1_k127_1592104_4 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 1.987e-303 953.0
PYH1_k127_1592104_40 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.0005948 42.0
PYH1_k127_1592104_5 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 533.0
PYH1_k127_1592104_6 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 510.0
PYH1_k127_1592104_7 Belongs to the phosphohexose mutase family K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 423.0
PYH1_k127_1592104_8 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 419.0
PYH1_k127_1592104_9 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 409.0
PYH1_k127_1595086_0 Sulphur transport K07112 - - 0.00000000001543 76.0
PYH1_k127_1595086_1 Belongs to the sulfur carrier protein TusA family K07112 - - 0.00000000131 65.0
PYH1_k127_1642024_0 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00135,K00138,K00146 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 538.0
PYH1_k127_1642024_1 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000000000000000003687 208.0
PYH1_k127_1642024_2 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000001383 168.0
PYH1_k127_1642024_3 NADPH-dependent FMN reductase - - - 0.00000000001031 74.0
PYH1_k127_1681322_0 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000001231 174.0
PYH1_k127_1681322_1 Belongs to the UPF0273 family - - - 0.000000000000000000000000000000000001347 147.0
PYH1_k127_1681322_2 Belongs to the UPF0273 family - - - 0.0000000007166 72.0
PYH1_k127_1757004_0 amidohydrolase K21613 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 369.0
PYH1_k127_1757004_1 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 322.0
PYH1_k127_1757004_2 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000000000000005824 89.0
PYH1_k127_177727_0 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000006804 180.0
PYH1_k127_177727_1 Response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000002159 116.0
PYH1_k127_177727_2 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000001877 114.0
PYH1_k127_177727_3 Glycosyl transferase family 2 - - - 0.0000000000004941 79.0
PYH1_k127_1781943_0 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000007163 171.0
PYH1_k127_1781943_1 Belongs to the peptidase S8 family K13735,K20276,K21449 - - 0.00000000000000002948 96.0
PYH1_k127_1781943_2 Cytochrome C biogenesis protein transmembrane region - - - 0.00000008394 64.0
PYH1_k127_1781943_3 metallocarboxypeptidase activity K01296 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009653,GO:0009986,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0032502,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0044464,GO:0048856,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.17.12 0.00007111 51.0
PYH1_k127_1806815_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 GO:0000287,GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016830,GO:0016832,GO:0019203,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0046483,GO:0046496,GO:0046872,GO:0050308,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564,GO:1901576 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 521.0
PYH1_k127_1806815_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 510.0
PYH1_k127_1806815_10 PFAM Methionine synthase, vitamin-B12 independent K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.000000000000000005071 95.0
PYH1_k127_1806815_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000003932 70.0
PYH1_k127_1806815_12 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00002587 57.0
PYH1_k127_1806815_2 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008875 434.0
PYH1_k127_1806815_3 Glycerate kinase K11529 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 366.0
PYH1_k127_1806815_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000001145 234.0
PYH1_k127_1806815_5 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000005623 192.0
PYH1_k127_1806815_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000002342 168.0
PYH1_k127_1806815_7 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.00000000000000000000000000000000000000009599 164.0
PYH1_k127_1806815_8 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000008819 133.0
PYH1_k127_1806815_9 4Fe-4S binding domain - - - 0.0000000000000000000000000002845 126.0
PYH1_k127_1809334_0 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000001312 208.0
PYH1_k127_1809334_1 Serine threonine protein kinase - - - 0.00000000000000000000000000001002 132.0
PYH1_k127_1809334_2 TIR domain - - - 0.00001842 54.0
PYH1_k127_1820573_0 Belongs to the MCM family K10726 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 518.0
PYH1_k127_1820573_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000000000000000000000000000000001117 229.0
PYH1_k127_1967280_0 Putative TM nitroreductase - - - 0.00000000000000000000000000000000002344 141.0
PYH1_k127_1967280_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000002719 131.0
PYH1_k127_1967280_2 Rhodanese Homology Domain - - - 0.000000000000000000000000007532 126.0
PYH1_k127_1967280_4 Beta-Casp domain K07576 - - 0.000000007407 57.0
PYH1_k127_2016149_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 479.0
PYH1_k127_2016149_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 426.0
PYH1_k127_2016149_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009036 296.0
PYH1_k127_2016149_3 PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000001568 181.0
PYH1_k127_2016149_4 Ribosome biogenesis protein, C-terminal K09140 - - 0.0000000000000000000000000000000002119 138.0
PYH1_k127_2016149_5 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.00000000000000000000000000000007367 130.0
PYH1_k127_2016149_6 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000002319 113.0
PYH1_k127_2016149_7 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.00000000000000002297 83.0
PYH1_k127_2016149_8 PAC2 family K07159 - - 0.000000000709 68.0
PYH1_k127_2016149_9 Transcriptional regulator, TrmB - - - 0.0000001311 58.0
PYH1_k127_2093258_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 4.201e-201 643.0
PYH1_k127_2093258_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000155 69.0
PYH1_k127_2093258_2 Dehydrogenase K00074 - 1.1.1.157 0.00000000006077 68.0
PYH1_k127_2093258_4 Universal stress protein K06149 - - 0.0000007867 57.0
PYH1_k127_2093258_5 ATP synthase (E/31 kDa) subunit K02150 GO:0000221,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015988,GO:0015991,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016471,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031224,GO:0032991,GO:0033176,GO:0033178,GO:0033180,GO:0034220,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045851,GO:0046961,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0090662,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098796,GO:0098805,GO:0098852,GO:0099131,GO:0099132,GO:1902600 - 0.00001879 54.0
PYH1_k127_2093258_6 H subunit K02107 - - 0.0001686 48.0
PYH1_k127_212652_0 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000002824 215.0
PYH1_k127_212652_1 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000002797 184.0
PYH1_k127_212652_2 Peptidase family M28 K19702 - 3.4.11.24 0.0000000000000002943 92.0
PYH1_k127_212652_3 DinB family - - - 0.00000001825 62.0
PYH1_k127_2159108_0 Psort location Cytoplasmic, score K00812,K10907 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 400.0
PYH1_k127_2159108_1 Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000001869 169.0
PYH1_k127_224572_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1196.0
PYH1_k127_224572_1 nucleotide-excision repair K03702,K08999 - - 4.834e-261 820.0
PYH1_k127_224572_10 Nitroreductase family K10678,K19285 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016657,GO:0032553,GO:0034567,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.5.1.38 0.0000000000000000000007711 104.0
PYH1_k127_224572_11 Alkaline and neutral invertase - - - 0.0000000000000143 85.0
PYH1_k127_224572_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 496.0
PYH1_k127_224572_3 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 443.0
PYH1_k127_224572_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 400.0
PYH1_k127_224572_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000001159 211.0
PYH1_k127_224572_6 Phosphoribosyl transferase domain K00759,K09685 - 2.4.2.7 0.0000000000000000000000000000000000001392 147.0
PYH1_k127_224572_7 NUDIX domain - - - 0.0000000000000000000000000000000001321 139.0
PYH1_k127_224572_8 OsmC-like protein K09136 - - 0.000000000000000000000000001763 115.0
PYH1_k127_224572_9 Deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.000000000000000000000000006265 115.0
PYH1_k127_2251115_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 362.0
PYH1_k127_2251115_1 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000001535 246.0
PYH1_k127_2251115_2 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.000000000000000000000000003764 115.0
PYH1_k127_2265751_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001003 257.0
PYH1_k127_2265751_1 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.000000000000000000000000000000000000000000000000000000000000000000009379 243.0
PYH1_k127_2265751_2 PFAM bifunctional deaminase-reductase domain protein K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.000000000000000000000000000000000000000000000000000000459 199.0
PYH1_k127_2265751_3 response regulator, receiver K07669 - - 0.00000000000000000000000001119 114.0
PYH1_k127_2265751_4 Highly conserved protein containing a thioredoxin domain - - - 0.000000000000000000009171 97.0
PYH1_k127_2337763_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000002171 140.0
PYH1_k127_2337763_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.0000000000000000000000000014 124.0
PYH1_k127_2356062_0 peptidase activity, acting on L-amino acid peptides - - - 0.000000000000000000000000000000000000000000000000000000003603 216.0
PYH1_k127_2356062_1 - - - - 0.000000000000000000002599 101.0
PYH1_k127_2356062_2 Domain of unknown function (DUF1508) K09946 - - 0.0000000000000000016 86.0
PYH1_k127_2423842_0 3-beta hydroxysteroid dehydrogenase/isomerase family K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 372.0
PYH1_k127_2423842_1 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001193 284.0
PYH1_k127_2423842_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000002206 245.0
PYH1_k127_2423842_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000177 59.0
PYH1_k127_2423842_4 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000005878 58.0
PYH1_k127_248602_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 471.0
PYH1_k127_248602_1 Formylmethanofuran-tetrahydromethanopterin formyltransferase K00672 - 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 393.0
PYH1_k127_248602_10 MazG-like family - - - 0.0000000000000000000000001503 112.0
PYH1_k127_248602_11 Sodium hydrogen exchanger - - - 0.000000000000000000001998 97.0
PYH1_k127_248602_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000002729 74.0
PYH1_k127_248602_13 Belongs to the sulfur carrier protein TusA family - - - 0.0000007675 54.0
PYH1_k127_248602_14 - - - - 0.000885 46.0
PYH1_k127_248602_2 Aspartate carbamoyltransferase K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 363.0
PYH1_k127_248602_3 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 380.0
PYH1_k127_248602_4 Protein of unknown function (DUF2961) K14109 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 300.0
PYH1_k127_248602_5 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 289.0
PYH1_k127_248602_6 radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000001683 246.0
PYH1_k127_248602_7 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000514 255.0
PYH1_k127_248602_8 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000001125 244.0
PYH1_k127_248602_9 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000002303 177.0
PYH1_k127_2545958_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 374.0
PYH1_k127_2545958_1 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000005244 236.0
PYH1_k127_2545958_2 short-chain K00034,K00038,K00046 - 1.1.1.47,1.1.1.53,1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000009276 221.0
PYH1_k127_2545958_3 Acetamidase/Formamidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000001075 218.0
PYH1_k127_2545958_4 Domain of unknown function (DUF2088) - - - 0.0000228 50.0
PYH1_k127_2548697_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 3.367e-210 668.0
PYH1_k127_2548697_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 510.0
PYH1_k127_2548697_10 Lysine biosynthesis K05827 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 288.0
PYH1_k127_2548697_11 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001338 285.0
PYH1_k127_2548697_12 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000006111 199.0
PYH1_k127_2548697_13 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000003179 192.0
PYH1_k127_2548697_14 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000007639 162.0
PYH1_k127_2548697_15 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001739 159.0
PYH1_k127_2548697_16 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000006098 146.0
PYH1_k127_2548697_17 Belongs to the eukaryotic ribosomal protein eS28 family K02979 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904 - 0.000000000000000000000000002702 112.0
PYH1_k127_2548697_18 binds to the 23S rRNA K02896 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.000000000000000006946 84.0
PYH1_k127_2548697_19 lysine biosynthesis protein LysW K05826 - - 0.00000000000001168 76.0
PYH1_k127_2548697_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 494.0
PYH1_k127_2548697_20 lysine biosynthesis protein LysW K05826 - - 0.0000000000271 66.0
PYH1_k127_2548697_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005525 484.0
PYH1_k127_2548697_4 Homocitrate synthase K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004426 479.0
PYH1_k127_2548697_5 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 434.0
PYH1_k127_2548697_6 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009571 431.0
PYH1_k127_2548697_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 428.0
PYH1_k127_2548697_8 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 302.0
PYH1_k127_2548697_9 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 304.0
PYH1_k127_2613170_0 SMART Elongator protein 3 MiaB NifB K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 423.0
PYH1_k127_2613170_1 Peptidase M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000001743 235.0
PYH1_k127_2613170_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.0000000000000000000000000000000000000000003097 163.0
PYH1_k127_2613170_3 Ribosomal protein S30 K02983 - - 0.0000000007156 62.0
PYH1_k127_267391_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 5.782e-201 640.0
PYH1_k127_267391_1 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004539 237.0
PYH1_k127_267391_2 conserved protein, contains double-stranded beta-helix domain - - - 0.0000000000001908 75.0
PYH1_k127_267391_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000003138 50.0
PYH1_k127_2780487_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000063 574.0
PYH1_k127_2780487_1 Beta-lactamase superfamily domain K03476 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002833 266.0
PYH1_k127_2780487_2 Universal stress protein - - - 0.00000000000000000000000001371 114.0
PYH1_k127_2999856_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 561.0
PYH1_k127_2999856_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 310.0
PYH1_k127_3019621_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 1.7e-249 779.0
PYH1_k127_3019621_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 505.0
PYH1_k127_3019621_10 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000004055 194.0
PYH1_k127_3019621_11 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 0.0000000000000000000000000000000000000000000002295 181.0
PYH1_k127_3019621_12 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000001566 145.0
PYH1_k127_3019621_13 PFAM UBA THIF-type NAD FAD binding protein - - - 0.0000000000000000000000000000005455 137.0
PYH1_k127_3019621_14 PFAM Peptidase S53, propeptide - - - 0.00000000000000000004806 102.0
PYH1_k127_3019621_15 helix_turn_helix, Arsenical Resistance Operon Repressor K22043 - - 0.0000000001505 65.0
PYH1_k127_3019621_16 Belongs to the ubiquitin-conjugating enzyme family K10583 - 2.3.2.23 0.0000000001611 69.0
PYH1_k127_3019621_17 Right handed beta helix region - - - 0.000001815 61.0
PYH1_k127_3019621_2 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 468.0
PYH1_k127_3019621_3 Belongs to the eIF-2B alpha beta delta subunits family K18237 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 343.0
PYH1_k127_3019621_4 geranylgeranyl reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002346 280.0
PYH1_k127_3019621_5 PFAM aminotransferase class V - GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000001435 236.0
PYH1_k127_3019621_6 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000002993 227.0
PYH1_k127_3019621_7 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000004399 222.0
PYH1_k127_3019621_8 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000001151 205.0
PYH1_k127_3019621_9 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000001681 196.0
PYH1_k127_3023908_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007843 264.0
PYH1_k127_3023908_1 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000001109 240.0
PYH1_k127_3023908_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000005242 179.0
PYH1_k127_3023908_3 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000003425 153.0
PYH1_k127_3023908_4 Beta Propeller - - - 0.0000000000000000000000000004339 131.0
PYH1_k127_3049197_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.883e-220 699.0
PYH1_k127_3049197_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 2.716e-201 644.0
PYH1_k127_3049197_10 Type III effector Hrp-dependent K22129 - 2.7.1.219,2.7.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 302.0
PYH1_k127_3049197_11 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002243 279.0
PYH1_k127_3049197_12 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001336 261.0
PYH1_k127_3049197_13 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001852 243.0
PYH1_k127_3049197_14 Class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000006989 211.0
PYH1_k127_3049197_15 Transferase hexapeptide repeat K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000008363 203.0
PYH1_k127_3049197_16 4Fe-4S dicluster domain K00196 - - 0.00000000000000000000000000000000000000000000000000009271 192.0
PYH1_k127_3049197_17 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000001976 183.0
PYH1_k127_3049197_18 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000002393 175.0
PYH1_k127_3049197_19 Adenylylsulphate kinase K00860 - 2.7.1.25 0.00000000000000000000000000000000000000000000113 171.0
PYH1_k127_3049197_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 9.492e-197 623.0
PYH1_k127_3049197_20 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000000000000006265 157.0
PYH1_k127_3049197_21 KaiC - - - 0.000000000000000000000000000000000000001797 157.0
PYH1_k127_3049197_22 Conserved protein implicated in secretion - - - 0.00000000000000000000000000000000000000714 155.0
PYH1_k127_3049197_23 hydrolase activity - - - 0.000000000000000000000000000000000001613 145.0
PYH1_k127_3049197_24 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000000000002623 134.0
PYH1_k127_3049197_25 Conserved protein implicated in secretion - - - 0.00000000000000000000000000003182 124.0
PYH1_k127_3049197_26 ribosomal protein K02976 - - 0.0000000000000000000000000004646 115.0
PYH1_k127_3049197_27 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000002527 119.0
PYH1_k127_3049197_28 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000007271 124.0
PYH1_k127_3049197_29 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000001122 113.0
PYH1_k127_3049197_3 4Fe-4S single cluster domain K06937 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 475.0
PYH1_k127_3049197_30 Conserved protein implicated in secretion - - - 0.0000000000000000000000006943 114.0
PYH1_k127_3049197_31 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000273 114.0
PYH1_k127_3049197_32 - - - - 0.000000000000000000005451 100.0
PYH1_k127_3049197_33 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000001256 96.0
PYH1_k127_3049197_34 - - - - 0.00000000000000001615 91.0
PYH1_k127_3049197_35 transcriptional regulator PadR family - - - 0.0000000000001056 76.0
PYH1_k127_3049197_36 - - - - 0.00000000004237 65.0
PYH1_k127_3049197_37 - - - - 0.000000000218 74.0
PYH1_k127_3049197_38 Signal peptidase K13280 GO:0003674,GO:0003824,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:0140096,GO:1901564 3.4.21.89 0.00000007454 61.0
PYH1_k127_3049197_39 transcriptional K03719 GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000009634 57.0
PYH1_k127_3049197_4 DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 402.0
PYH1_k127_3049197_5 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 399.0
PYH1_k127_3049197_6 Belongs to the PdxA family K22024 - 1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 389.0
PYH1_k127_3049197_7 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 386.0
PYH1_k127_3049197_8 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 376.0
PYH1_k127_3049197_9 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 315.0
PYH1_k127_3069850_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 2.228e-243 782.0
PYH1_k127_3069850_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 495.0
PYH1_k127_3069850_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000006238 220.0
PYH1_k127_3069850_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000005622 202.0
PYH1_k127_3069850_4 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000002018 201.0
PYH1_k127_3069850_5 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000001201 141.0
PYH1_k127_3069850_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000001672 91.0
PYH1_k127_3069850_7 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.000008203 51.0
PYH1_k127_3070883_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 553.0
PYH1_k127_3070883_1 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000006728 148.0
PYH1_k127_319528_0 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 607.0
PYH1_k127_319528_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000009355 231.0
PYH1_k127_319528_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000002664 124.0
PYH1_k127_319528_3 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.0000000000000000002587 87.0
PYH1_k127_319528_4 ThiS family K03636 - - 0.00000004586 59.0
PYH1_k127_3351883_0 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000000000000000000000004131 212.0
PYH1_k127_3351883_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000003239 168.0
PYH1_k127_3351883_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000002245 149.0
PYH1_k127_3351883_3 Glycoprotease family - - - 0.00000000000000000000000002563 116.0
PYH1_k127_3351883_4 redox protein regulator of disulfide bond formation - - - 0.0000000000000002821 80.0
PYH1_k127_3351883_5 Thioesterase-like superfamily K07107 - - 0.00000000000005421 77.0
PYH1_k127_3351883_6 Transcriptional regulator K07108 - - 0.00000000001468 68.0
PYH1_k127_3351883_7 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.00000004774 55.0
PYH1_k127_3363339_0 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000003845 186.0
PYH1_k127_3363339_1 Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000004559 134.0
PYH1_k127_3363339_2 Peptidase C13 family - - - 0.000001143 58.0
PYH1_k127_3363339_3 Luciferase-like monooxygenase - - - 0.000001223 60.0
PYH1_k127_3363339_4 Methyltransferase domain - - - 0.00003804 53.0
PYH1_k127_3394100_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 5.118e-211 670.0
PYH1_k127_3394100_1 PFAM chaperonin Cpn60 TCP-1 K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000004142 218.0
PYH1_k127_3394100_2 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000002146 109.0
PYH1_k127_3394100_3 Parallel beta-helix repeats - - - 0.00000000502 68.0
PYH1_k127_3468046_0 Phosphomethylpyrimidine kinase K00941,K21219,K21220 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 493.0
PYH1_k127_3468046_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 484.0
PYH1_k127_3468046_10 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000004793 185.0
PYH1_k127_3468046_11 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000009286 184.0
PYH1_k127_3468046_12 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000007475 178.0
PYH1_k127_3468046_13 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000007973 178.0
PYH1_k127_3468046_14 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000007543 176.0
PYH1_k127_3468046_15 Conserved hypothetical protein 95 K07579 - - 0.00000000000000000000000000000000000000000001074 170.0
PYH1_k127_3468046_16 Belongs to the universal ribosomal protein uL16 family K02866 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000003209 166.0
PYH1_k127_3468046_17 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000008597 156.0
PYH1_k127_3468046_18 TIGRFAM RNA methyltransferase, TrmH family, group 1 - - - 0.0000000000000000000000000000000000009195 148.0
PYH1_k127_3468046_19 TIGRFAM thiW protein - - - 0.000000000000000000000000000000000001261 144.0
PYH1_k127_3468046_2 Permease for cytosine/purines, uracil, thiamine, allantoin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 411.0
PYH1_k127_3468046_20 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000001053 121.0
PYH1_k127_3468046_21 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000001893 111.0
PYH1_k127_3468046_22 Belongs to the eukaryotic ribosomal protein eL21 family K02889 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000001655 108.0
PYH1_k127_3468046_23 Ribonuclease III - - - 0.0000000000000000001225 94.0
PYH1_k127_3468046_24 Glycosyl transferase family group 2 - - - 0.00000000000000001329 95.0
PYH1_k127_3468046_25 polynucleotide 5'-hydroxyl-kinase activity K06947 - - 0.00000000000000001978 90.0
PYH1_k127_3468046_26 PIN domain of ribonuclease K07060 GO:0000469,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0030490,GO:0030684,GO:0030688,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1990904 - 0.00000000000000007055 88.0
PYH1_k127_3468046_27 protein transport - - - 0.0000000000000001197 83.0
PYH1_k127_3468046_28 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000003711 76.0
PYH1_k127_3468046_29 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.00000002883 59.0
PYH1_k127_3468046_3 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 302.0
PYH1_k127_3468046_30 - - - - 0.000009376 56.0
PYH1_k127_3468046_31 Glycosyl hydrolases family 18 K01183 - 3.2.1.14 0.0002994 52.0
PYH1_k127_3468046_32 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0004734 47.0
PYH1_k127_3468046_33 Cytochrome D1 heme domain - - - 0.0006157 48.0
PYH1_k127_3468046_4 Deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000251 282.0
PYH1_k127_3468046_5 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002378 273.0
PYH1_k127_3468046_6 Diphthamide K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000002564 248.0
PYH1_k127_3468046_7 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000000000000000000000000000001367 218.0
PYH1_k127_3468046_8 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000002093 206.0
PYH1_k127_3468046_9 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000006148 197.0
PYH1_k127_350814_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 404.0
PYH1_k127_350814_1 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008614 246.0
PYH1_k127_350814_2 PAC2 family K07159 - - 0.00000000000000000000000000000000000008123 151.0
PYH1_k127_350814_3 PFAM PAC2 family K06869 - - 0.0000000000000000000000000000000009708 139.0
PYH1_k127_350814_4 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000001846 135.0
PYH1_k127_350814_5 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000243 111.0
PYH1_k127_350814_6 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000002184 102.0
PYH1_k127_350814_7 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.00000000000001533 76.0
PYH1_k127_350814_8 protein, 4-oxalocrotonate tautomerase homolog K01821 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237 5.3.2.6 0.0000000001824 64.0
PYH1_k127_350814_9 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000007223 59.0
PYH1_k127_3524165_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000003588 244.0
PYH1_k127_3524165_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03237 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000003074 202.0
PYH1_k127_3524165_2 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000001677 187.0
PYH1_k127_3524165_3 Binds to the 23S rRNA K02929 - - 0.0000000000000000000000000008018 115.0
PYH1_k127_3524165_4 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000112 78.0
PYH1_k127_3524165_5 PFAM Ribosomal protein S27E K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000005799 78.0
PYH1_k127_3524165_6 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000004284 65.0
PYH1_k127_3524165_7 protein conserved in archaea K09723 - - 0.0005764 50.0
PYH1_k127_3590903_0 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 4.489e-276 865.0
PYH1_k127_3590903_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 5.771e-199 641.0
PYH1_k127_3590903_10 Domain of unknown function (DUF362) - - - 0.0000000000000000000182 103.0
PYH1_k127_3590903_2 pseudouridine synthase activity K06176 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 417.0
PYH1_k127_3590903_3 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 368.0
PYH1_k127_3590903_4 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001003 289.0
PYH1_k127_3590903_5 Domain of unknown function (DUF362) K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000009365 246.0
PYH1_k127_3590903_6 Integral membrane protein DUF92 K00981,K18678 GO:0005575,GO:0016020 2.7.1.182,2.7.7.41 0.00000000000000000000000000000000000000004873 162.0
PYH1_k127_3590903_7 PFAM phosphatidate cytidylyltransferase K18678 - 2.7.1.182 0.0000000000000000000000000000000000338 143.0
PYH1_k127_3590903_8 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000003845 139.0
PYH1_k127_3590903_9 Belongs to the UPF0235 family K09131 - - 0.00000000000000000001223 93.0
PYH1_k127_3631711_0 Domain of unknown function (DUF2088) K22373 - 5.1.2.1 0.000000000000000000003628 105.0
PYH1_k127_3631711_1 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 0.0000000001698 70.0
PYH1_k127_3667274_0 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 484.0
PYH1_k127_3667274_1 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 313.0
PYH1_k127_3667274_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 303.0
PYH1_k127_3667274_3 peptidase - - - 0.00000000002544 70.0
PYH1_k127_3667274_4 membrane protein (DUF2078) K08982 - - 0.000000122 59.0
PYH1_k127_3749858_0 carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 403.0
PYH1_k127_3749858_1 acetyl coenzyme A synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 377.0
PYH1_k127_3749858_10 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000121 156.0
PYH1_k127_3749858_11 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000004108 131.0
PYH1_k127_3749858_12 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000005074 111.0
PYH1_k127_3749858_13 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.00000000000000000000001588 110.0
PYH1_k127_3749858_14 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.0000000000000000001688 93.0
PYH1_k127_3749858_15 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000001574 87.0
PYH1_k127_3749858_16 Bacterial lipoate protein ligase C-terminus K03800 - 6.3.1.20 0.0000000001278 65.0
PYH1_k127_3749858_2 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 349.0
PYH1_k127_3749858_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 317.0
PYH1_k127_3749858_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 294.0
PYH1_k127_3749858_5 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003046 276.0
PYH1_k127_3749858_6 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003278 258.0
PYH1_k127_3749858_7 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000001758 256.0
PYH1_k127_3749858_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006511 267.0
PYH1_k127_3749858_9 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000006112 207.0
PYH1_k127_3759263_0 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000002886 233.0
PYH1_k127_3759263_1 CoA binding domain K01905 - 6.2.1.13 0.00000000000000000000000000000000000000000000000003121 186.0
PYH1_k127_3759263_2 Domain of unknown function DUF87 K06915 - - 0.0000000000000000000000000000000000006376 151.0
PYH1_k127_3759263_3 F420H(2)-dependent quinone reductase - - - 0.000004869 49.0
PYH1_k127_3759263_4 pyridoxamine 5'-phosphate oxidase-related, FMN-binding - - - 0.0006973 45.0
PYH1_k127_3778226_0 COG3256 Nitric oxide reductase large subunit K04561 - 1.7.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006963 597.0
PYH1_k127_3778226_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 365.0
PYH1_k127_3778226_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 291.0
PYH1_k127_3778226_3 Histidine Phosphotransfer domain K03413,K07662,K07667,K11443 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001511 271.0
PYH1_k127_3778226_4 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000003872 177.0
PYH1_k127_3778226_5 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000001368 137.0
PYH1_k127_3778226_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000000000000136 117.0
PYH1_k127_387211_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 356.0
PYH1_k127_387211_1 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000007346 165.0
PYH1_k127_387211_2 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000001505 121.0
PYH1_k127_387211_3 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.00000000000000000000008099 109.0
PYH1_k127_387211_4 Methyltransferase type 11 - - - 0.000000000001502 74.0
PYH1_k127_387211_5 Maltose acetyltransferase - - - 0.00000006547 64.0
PYH1_k127_387211_6 group 2 family protein - - - 0.0000001419 63.0
PYH1_k127_387211_7 - - - - 0.000001183 53.0
PYH1_k127_387211_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0005006 48.0
PYH1_k127_4015235_0 TIGRFAM dihydroorotate dehydrogenase family protein K00226,K17723 - 1.3.1.1,1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 341.0
PYH1_k127_4015235_1 COG0607 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 329.0
PYH1_k127_4015235_2 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001719 257.0
PYH1_k127_4015235_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000642 224.0
PYH1_k127_41085_0 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000003378 213.0
PYH1_k127_41085_1 - - - - 0.0000004862 60.0
PYH1_k127_4166484_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 5.851e-196 629.0
PYH1_k127_4166484_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00018 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.26,1.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 381.0
PYH1_k127_4166484_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000007563 226.0
PYH1_k127_4166484_3 - - - - 0.0000000000000000000000000000000000000000000000000000004497 199.0
PYH1_k127_4166484_4 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000006893 182.0
PYH1_k127_4166484_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00196 - - 0.000000000000000000000000000005724 125.0
PYH1_k127_4166484_6 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000003143 109.0
PYH1_k127_4166484_7 TIGRFAM MoaD family protein K03636 - - 0.0000143 51.0
PYH1_k127_422522_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000002418 193.0
PYH1_k127_422522_1 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000000000001628 193.0
PYH1_k127_422522_2 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000001409 169.0
PYH1_k127_422522_3 - - - - 0.0000000000000000000000003026 117.0
PYH1_k127_422522_4 Rad50 zinc hook motif K03546 - - 0.00000000000000001368 96.0
PYH1_k127_422522_6 Domain of unknown function (DUF4389) - - - 0.00000107 57.0
PYH1_k127_4309434_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 339.0
PYH1_k127_4309434_1 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 320.0
PYH1_k127_4309434_2 PFAM Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000001262 257.0
PYH1_k127_4309434_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000001019 171.0
PYH1_k127_4309434_4 ribosomal protein S15 K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000009158 156.0
PYH1_k127_4482925_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 384.0
PYH1_k127_4482925_1 Belongs to the eukaryotic ribosomal protein eS1 family K02984 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000005829 190.0
PYH1_k127_4546687_0 PFAM chaperonin Cpn60 TCP-1 K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077 - 6.543e-195 622.0
PYH1_k127_4546687_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 526.0
PYH1_k127_4546687_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000001898 181.0
PYH1_k127_4546687_3 protein secretion by the type IV secretion system - - - 0.00000000000000000000000002899 127.0
PYH1_k127_4546687_4 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000009761 65.0
PYH1_k127_4546687_5 - - - - 0.0000004132 64.0
PYH1_k127_4561101_0 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000005213 242.0
PYH1_k127_4561101_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K13566 - 3.5.1.3 0.0000000000000000000000000000000000001071 151.0
PYH1_k127_4561101_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000003644 117.0
PYH1_k127_4561101_3 Carbamoyl-phosphate synthetase large chain oligomerisation K01955 - 6.3.5.5 0.0000000008038 67.0
PYH1_k127_4561101_4 ECF-type riboflavin transporter, S component - - - 0.00000001934 63.0
PYH1_k127_4563150_0 AIR synthase related protein, C-terminal domain K01952 - 6.3.5.3 2.79e-210 677.0
PYH1_k127_4563150_1 phosphoenolpyruvate carboxykinase (ATP) activity K01610 - 4.1.1.49 3.467e-203 662.0
PYH1_k127_4563150_10 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000001904 143.0
PYH1_k127_4563150_11 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.00000000000000000000000000006888 117.0
PYH1_k127_4563150_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000003324 87.0
PYH1_k127_4563150_13 GCN5-related N-acetyl-transferase - - - 0.0000000007311 63.0
PYH1_k127_4563150_14 - - - - 0.00000004086 60.0
PYH1_k127_4563150_15 molybdopterin-guanine dinucleotide biosynthesis protein K03635,K03753 - 2.8.1.12 0.0002209 47.0
PYH1_k127_4563150_2 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 398.0
PYH1_k127_4563150_3 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 336.0
PYH1_k127_4563150_4 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009368 313.0
PYH1_k127_4563150_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005366 269.0
PYH1_k127_4563150_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000001727 229.0
PYH1_k127_4563150_7 PFAM metallophosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000002183 192.0
PYH1_k127_4563150_8 Aminotransferase K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.000000000000000000000000000000000000000001848 179.0
PYH1_k127_4563150_9 Endoribonuclease L-PSP K09022 GO:0003674,GO:0003824,GO:0016787,GO:0019239 3.5.99.10 0.0000000000000000000000000000000001629 136.0
PYH1_k127_4568676_0 Succinyl-CoA ligase like flavodoxin domain K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 525.0
PYH1_k127_4568676_1 alcohol dehydrogenase K19954 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 296.0
PYH1_k127_4568676_2 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000009081 244.0
PYH1_k127_4568676_3 Portal protein K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000009614 98.0
PYH1_k127_4568676_4 lactoylglutathione lyase activity K01239,K08234 - 3.2.2.1 0.0000006707 57.0
PYH1_k127_4787348_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 556.0
PYH1_k127_4787348_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 542.0
PYH1_k127_4787348_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006256 278.0
PYH1_k127_4787348_3 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000003765 222.0
PYH1_k127_4817930_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 606.0
PYH1_k127_4817930_1 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 559.0
PYH1_k127_4817930_10 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000003529 207.0
PYH1_k127_4817930_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000001304 196.0
PYH1_k127_4817930_12 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615 2.7.1.36 0.00000000000000000000000000000000000000000000000000005751 199.0
PYH1_k127_4817930_13 serine threonine protein kinase K08851 GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.11.1 0.00000000000000000000000000000000000000000000000004204 185.0
PYH1_k127_4817930_14 PFAM UbiA prenyltransferase K17105 - 2.5.1.42 0.00000000000000000000000000000000000000000003057 172.0
PYH1_k127_4817930_15 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036222,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000004011 167.0
PYH1_k127_4817930_16 Predicted membrane protein (DUF2070) K08979 - - 0.00000000000000000000000000000000000000001021 174.0
PYH1_k127_4817930_17 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000007574 140.0
PYH1_k127_4817930_18 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000003173 121.0
PYH1_k127_4817930_19 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.00000000000000000000000001001 114.0
PYH1_k127_4817930_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 473.0
PYH1_k127_4817930_20 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000002671 109.0
PYH1_k127_4817930_21 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000004181 98.0
PYH1_k127_4817930_22 SMART Nucleotide binding protein, PINc K07158 - - 0.0000000000000000000193 96.0
PYH1_k127_4817930_23 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000004866 90.0
PYH1_k127_4817930_24 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000007992 81.0
PYH1_k127_4817930_25 Belongs to the UPF0218 family K09735 - - 0.0000000000000008453 84.0
PYH1_k127_4817930_26 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000001334 62.0
PYH1_k127_4817930_27 AsnC family - - - 0.00000003565 57.0
PYH1_k127_4817930_28 PFAM regulatory protein AsnC Lrp family - - - 0.00005842 50.0
PYH1_k127_4817930_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 387.0
PYH1_k127_4817930_4 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 360.0
PYH1_k127_4817930_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 354.0
PYH1_k127_4817930_6 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 349.0
PYH1_k127_4817930_7 Belongs to the MEMO1 family K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007727 292.0
PYH1_k127_4817930_8 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000002742 257.0
PYH1_k127_4817930_9 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000009859 248.0
PYH1_k127_4890273_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 308.0
PYH1_k127_4890273_1 50S ribosomal protein L4 K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001587 258.0
PYH1_k127_4890273_10 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000003097 137.0
PYH1_k127_4890273_11 Located at the polypeptide exit tunnel on the outside of the subunit K02895 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000001765 109.0
PYH1_k127_4890273_12 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000165 102.0
PYH1_k127_4890273_13 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.0000000000000000000001827 99.0
PYH1_k127_4890273_14 regulatory protein, arsR - - - 0.000000000011 71.0
PYH1_k127_4890273_15 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000006051 59.0
PYH1_k127_4890273_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000005272 253.0
PYH1_k127_4890273_3 Belongs to the eukaryotic ribosomal protein eS4 family K02987 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000001535 252.0
PYH1_k127_4890273_4 Binds the lower part of the 30S subunit head K02982 GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001595 212.0
PYH1_k127_4890273_5 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000008427 197.0
PYH1_k127_4890273_6 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000004804 184.0
PYH1_k127_4890273_7 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000244 190.0
PYH1_k127_4890273_8 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000002498 162.0
PYH1_k127_4890273_9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000002063 158.0
PYH1_k127_4956450_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000003782 177.0
PYH1_k127_4956450_1 Psort location Cytoplasmic, score K00008 - 1.1.1.14 0.000000000000000000000000000000000002748 151.0
PYH1_k127_4956450_2 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000005066 87.0
PYH1_k127_4956450_3 Glycosyl transferase, family 2 - - - 0.0000000004471 67.0
PYH1_k127_4956450_4 PFAM Glycosyl transferase, group 1 - - - 0.000000006681 61.0
PYH1_k127_5036979_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 4.9e-269 845.0
PYH1_k127_5036979_1 ABC-type cobalt transport system ATPase component K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003252 275.0
PYH1_k127_5036979_2 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000001836 223.0
PYH1_k127_5036979_3 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000002361 204.0
PYH1_k127_5036979_4 PFAM Cobalt transport protein K16785 - - 0.00000000000000000000000000000000000000000003027 170.0
PYH1_k127_5036979_5 ERCC4 domain protein K10848 - - 0.000000000000000000000000000000001771 139.0
PYH1_k127_5143122_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 314.0
PYH1_k127_5143122_1 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 316.0
PYH1_k127_5143122_2 alpha beta - - - 0.000000000000000000000000000000000000000000000000006476 192.0
PYH1_k127_5143122_3 PFAM DsrE DsrF-like family - - - 0.00000000000000000000000000000000000000000008776 164.0
PYH1_k127_5143122_4 TIGRFAM archaeal flagellin N-terminal-like domain - - - 0.00000000000000002591 88.0
PYH1_k127_5143122_5 Protein of unknown function (DUF998) - - - 0.0000000000000001861 87.0
PYH1_k127_5235133_0 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 581.0
PYH1_k127_5235133_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000001366 252.0
PYH1_k127_5235133_2 PFAM Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000006052 185.0
PYH1_k127_5235133_3 PFAM ApbE family K09740 - - 0.00000000000000000000000000000000000002249 153.0
PYH1_k127_5235133_4 4Fe-4S ferredoxin iron-sulfur binding - - - 0.000000000000000000000000001513 117.0
PYH1_k127_5235133_5 - - - - 0.0000000007452 70.0
PYH1_k127_5235133_6 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.0005006 48.0
PYH1_k127_5255854_0 PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000001998 219.0
PYH1_k127_5255854_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.4 0.000000000000000000000000000000000000000000000000000001721 198.0
PYH1_k127_5255854_2 nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000478 186.0
PYH1_k127_5255854_3 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.00000000000000000000000000000000000000000769 162.0
PYH1_k127_5255854_4 COG1111 ERCC4-like helicases K10896 - - 0.0000000000000000000000000000000008349 136.0
PYH1_k127_5255854_5 oxidation-reduction process K09022 - 3.5.99.10 0.000000000000000000000001354 108.0
PYH1_k127_5255854_6 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.000000000000000004604 91.0
PYH1_k127_5307010_0 heavy metal-(Cd Co Hg Pb Zn)-translocating K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 438.0
PYH1_k127_5307010_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 322.0
PYH1_k127_532055_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 304.0
PYH1_k127_532055_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 296.0
PYH1_k127_532055_10 Transcription factor Pcc1 K09741 - - 0.000005772 51.0
PYH1_k127_532055_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002002 257.0
PYH1_k127_532055_3 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001148 249.0
PYH1_k127_532055_4 PFAM ABC transporter related K03529,K06166,K16786,K16787 - 2.7.8.37 0.0000000000000000000000000000000000000000000000000000000000000005215 226.0
PYH1_k127_532055_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000004434 207.0
PYH1_k127_532055_6 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000005316 134.0
PYH1_k127_532055_7 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000005198 100.0
PYH1_k127_532055_8 binds to the 23S rRNA K02921 - - 0.00000000000000007545 85.0
PYH1_k127_532055_9 Probably involved in the biogenesis of the ribosome K14561 - - 0.000001146 57.0
PYH1_k127_5397269_0 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003849 282.0
PYH1_k127_5397269_1 acetyl coenzyme A synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004456 271.0
PYH1_k127_5397269_2 - K00960 - 2.7.7.6 0.00000000000000004601 81.0
PYH1_k127_5475577_0 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K00333,K14090 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007654 440.0
PYH1_k127_5475577_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 306.0
PYH1_k127_5475577_2 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002755 261.0
PYH1_k127_5475577_3 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14088 - - 0.0000000000000000000000000000000000000000000000000000000271 201.0
PYH1_k127_5475577_4 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.0000000000000000004295 93.0
PYH1_k127_5534973_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 340.0
PYH1_k127_5534973_1 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 301.0
PYH1_k127_5534973_10 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000002035 125.0
PYH1_k127_5534973_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000005602 121.0
PYH1_k127_5534973_12 Dolichyl-phosphate-mannose-protein mannosyltransferase K00728 - 2.4.1.109 0.0000000000000000000001416 111.0
PYH1_k127_5534973_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000004276 71.0
PYH1_k127_5534973_14 COG1199 Rad3-related DNA helicases - - - 0.00000000001427 72.0
PYH1_k127_5534973_15 Transporter - - - 0.00000001339 65.0
PYH1_k127_5534973_16 Peptidase family C25 - - - 0.000003847 60.0
PYH1_k127_5534973_17 - - - - 0.00004083 55.0
PYH1_k127_5534973_18 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0002416 44.0
PYH1_k127_5534973_2 Spore germination protein K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007669 274.0
PYH1_k127_5534973_3 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004613 247.0
PYH1_k127_5534973_4 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001593 233.0
PYH1_k127_5534973_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K19647 - 1.1.1.291,1.1.1.31 0.0000000000000000000000000000000000000000000000000000000008797 212.0
PYH1_k127_5534973_6 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000001829 164.0
PYH1_k127_5534973_7 Protein of unknown function DUF134 - - - 0.0000000000000000000000000000000000000001629 154.0
PYH1_k127_5534973_8 - - - - 0.0000000000000000000000000000000000001483 148.0
PYH1_k127_5534973_9 PFAM Dimethylmenaquinone methyltransferase - - - 0.0000000000000000000000000000000003825 140.0
PYH1_k127_5586606_0 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K00333,K14090 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 370.0
PYH1_k127_5586606_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002559 278.0
PYH1_k127_5586606_10 Domain of unknown function (DUF296) - - - 0.00000000000000000000000000000008961 130.0
PYH1_k127_5586606_11 4Fe-4S dicluster domain K12143 - - 0.000000000000000000000002512 112.0
PYH1_k127_5586606_12 Belongs to the eukaryotic ribosomal protein eL38 family K02923 - - 0.000005329 52.0
PYH1_k127_5586606_13 ThiS family K03636 - - 0.00004694 49.0
PYH1_k127_5586606_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0003153 51.0
PYH1_k127_5586606_2 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009512 249.0
PYH1_k127_5586606_3 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003023 245.0
PYH1_k127_5586606_4 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000003545 228.0
PYH1_k127_5586606_5 heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000853 220.0
PYH1_k127_5586606_6 NADH dehydrogenase K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000001313 220.0
PYH1_k127_5586606_7 NADH ubiquinone oxidoreductase, 20 Kd subunit K14088 - - 0.0000000000000000000000000000000000000000000000005692 183.0
PYH1_k127_5586606_8 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000002206 185.0
PYH1_k127_5586606_9 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000003367 184.0
PYH1_k127_562996_0 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 387.0
PYH1_k127_562996_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 363.0
PYH1_k127_562996_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000006345 206.0
PYH1_k127_562996_3 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000001927 148.0
PYH1_k127_562996_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K02201 - 2.7.7.3 0.000000000000000000000000006264 116.0
PYH1_k127_5634222_0 Protein of unknown function (DUF1512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 312.0
PYH1_k127_5634222_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000002525 262.0
PYH1_k127_5634222_2 phosphoribosyltransferase K07100 - - 0.0000000000000000000000000000000000000000000000000000000000001092 220.0
PYH1_k127_5634222_3 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000001793 128.0
PYH1_k127_5634222_4 GTPase of unknown function C-terminal K06942 - - 0.00000000000000000000000008603 107.0
PYH1_k127_5678999_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 4.32e-309 981.0
PYH1_k127_5678999_1 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 428.0
PYH1_k127_5678999_10 - - - - 0.000000007705 61.0
PYH1_k127_5678999_2 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 327.0
PYH1_k127_5678999_3 Oligosaccharyl transferase STT3 subunit K07151 GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006508,GO:0006511,GO:0006516,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0008250,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0019941,GO:0030163,GO:0030433,GO:0031984,GO:0032991,GO:0033554,GO:0034645,GO:0034976,GO:0035966,GO:0036211,GO:0036503,GO:0042175,GO:0042221,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043632,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051603,GO:0051716,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1902494,GO:1990234 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001091 287.0
PYH1_k127_5678999_4 Binds to RNA in loop regions with AU-rich sequences K22469 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000006128 170.0
PYH1_k127_5678999_5 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000006496 157.0
PYH1_k127_5678999_6 PFAM Molybdopterin guanine dinucleotide synthesis protein B K06947 - - 0.0000000000000000000000000000000000000492 156.0
PYH1_k127_5678999_7 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.000000000000000000000000000000000007174 140.0
PYH1_k127_5678999_8 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.0000000000000000000000000000000002966 137.0
PYH1_k127_5678999_9 DNA repair protein K10880,K10958 GO:0000003,GO:0000150,GO:0000217,GO:0000280,GO:0000400,GO:0000707,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0022607,GO:0030491,GO:0032200,GO:0032991,GO:0033061,GO:0033062,GO:0033063,GO:0033170,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0035861,GO:0042148,GO:0042592,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0046982,GO:0046983,GO:0048285,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090734,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046 - 0.00000000000005392 81.0
PYH1_k127_5791458_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002701 266.0
PYH1_k127_5791458_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000003306 203.0
PYH1_k127_5791458_2 UbiA prenyltransferase family K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000007622 187.0
PYH1_k127_5829031_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 449.0
PYH1_k127_5829031_1 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000004613 252.0
PYH1_k127_5829031_2 B3/4 domain - - - 0.0000000000000000000000000000000000000000000000000000000002522 210.0
PYH1_k127_5829031_3 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000000000000000000000000000000000000005938 191.0
PYH1_k127_5829031_4 UbiA prenyltransferase family K02257 - 2.5.1.141 0.0000000000000000000000000000000000001541 153.0
PYH1_k127_5829031_5 Psort location CytoplasmicMembrane, score K01534 - 3.6.3.3,3.6.3.5 0.00000006439 56.0
PYH1_k127_5915765_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 2.852e-242 762.0
PYH1_k127_5915765_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 4.125e-226 707.0
PYH1_k127_5915765_2 Thermophilic metalloprotease (M29) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 308.0
PYH1_k127_5915765_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000001004 158.0
PYH1_k127_5915765_4 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000001617 121.0
PYH1_k127_5915765_5 PFAM 4Fe-4S ferredoxin - - - 0.0000000000005864 70.0
PYH1_k127_5915765_6 Transcriptional regulator K22206 - - 0.00000001873 62.0
PYH1_k127_5915765_7 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000003094 57.0
PYH1_k127_5921969_0 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 399.0
PYH1_k127_5921969_1 PFAM Thiamine pyrophosphate K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 353.0
PYH1_k127_5921969_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004501 244.0
PYH1_k127_5921969_3 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000001732 180.0
PYH1_k127_5921969_4 Cupin domain protein - - - 0.00000000000000000000000000000000000006111 145.0
PYH1_k127_5921969_5 TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family K00171 - 1.2.7.1 0.0000000000000000000000000001136 119.0
PYH1_k127_5957980_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 488.0
PYH1_k127_5957980_1 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.00000000000000000000000000000000000005714 154.0
PYH1_k127_5957980_2 - - - - 0.00000000000000000004297 91.0
PYH1_k127_5957980_4 Peptidase C13 family - - - 0.0000000000000001236 93.0
PYH1_k127_5957980_5 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.000000001481 62.0
PYH1_k127_5957980_6 - - - - 0.0000002523 62.0
PYH1_k127_6016571_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 347.0
PYH1_k127_6016571_1 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001711 280.0
PYH1_k127_6016571_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001782 263.0
PYH1_k127_6016571_3 PhoU domain K02039 - - 0.000000000000000000000000000000000000000006418 162.0
PYH1_k127_6016571_4 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000000000000002844 149.0
PYH1_k127_6094912_0 GMP synthase, glutamine-hydrolyzing K01951 GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 307.0
PYH1_k127_6094912_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.00000000000000000000000000000000000000003119 155.0
PYH1_k127_6094912_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000001492 118.0
PYH1_k127_6098274_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 579.0
PYH1_k127_6098274_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000009038 235.0
PYH1_k127_6098274_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000647 224.0
PYH1_k127_6098274_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000216 212.0
PYH1_k127_6098274_4 - - - - 0.000000000038 74.0
PYH1_k127_6098274_5 protein conserved in archaea (DUF2153) - - - 0.000001182 55.0
PYH1_k127_6098274_6 gamma-glutamylcyclotransferase activity - - - 0.0002488 47.0
PYH1_k127_6119794_0 AIR synthase related protein, C-terminal domain K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 402.0
PYH1_k127_6119794_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000007453 207.0
PYH1_k127_6119794_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000003485 153.0
PYH1_k127_6119794_3 Hydrogenase formation hypA family K04654 - - 0.00000000000000000005627 91.0
PYH1_k127_6184693_0 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 544.0
PYH1_k127_6184693_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 317.0
PYH1_k127_6184693_2 Belongs to the binding-protein-dependent transport system permease family K01997,K01999 - - 0.0000000000000000009854 96.0
PYH1_k127_6184693_3 Nitroreductase - - - 0.0000000000002309 71.0
PYH1_k127_6212287_0 - - - - 0.000000000000000000000000000000000000000000000000000000001077 213.0
PYH1_k127_6212287_1 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases K03641 - - 0.00000000000000000000000000000000000000007101 162.0
PYH1_k127_6212287_2 - - - - 0.0000001862 54.0
PYH1_k127_6359425_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.158e-249 788.0
PYH1_k127_6359425_1 glutamine synthetase K01915 - 6.3.1.2 5.682e-228 714.0
PYH1_k127_6359425_10 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002512 284.0
PYH1_k127_6359425_11 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007543 278.0
PYH1_k127_6359425_12 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001065 265.0
PYH1_k127_6359425_13 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005306 250.0
PYH1_k127_6359425_14 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000001364 228.0
PYH1_k127_6359425_15 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000003112 171.0
PYH1_k127_6359425_16 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000006456 175.0
PYH1_k127_6359425_17 RNA methylase - GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000001318 161.0
PYH1_k127_6359425_18 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000004554 147.0
PYH1_k127_6359425_19 Cytidylyltransferase K19712 - 2.7.7.62 0.0000000000000000000000000000000003305 139.0
PYH1_k127_6359425_2 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 574.0
PYH1_k127_6359425_20 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.0000000000000000000000000000000003694 140.0
PYH1_k127_6359425_21 - - - - 0.000000000000000000000000000000005498 130.0
PYH1_k127_6359425_22 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000009803 136.0
PYH1_k127_6359425_23 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000006924 132.0
PYH1_k127_6359425_24 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000005248 113.0
PYH1_k127_6359425_25 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.000000000000000000000002422 117.0
PYH1_k127_6359425_26 COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components K02013 - 3.6.3.34 0.00000000000000001755 94.0
PYH1_k127_6359425_27 Putative Phosphatase K01079 - 3.1.3.3 0.0000000000000528 80.0
PYH1_k127_6359425_28 - - - - 0.00000000000204 76.0
PYH1_k127_6359425_29 TM2 domain - - - 0.00001351 55.0
PYH1_k127_6359425_3 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 448.0
PYH1_k127_6359425_30 CAAX protease self-immunity K07052 - - 0.0003295 51.0
PYH1_k127_6359425_4 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 380.0
PYH1_k127_6359425_5 PFAM ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 364.0
PYH1_k127_6359425_6 Transporter, major facilitator family protein K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009572 355.0
PYH1_k127_6359425_7 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 324.0
PYH1_k127_6359425_8 Imidazole acetol-phosphate transaminase K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 324.0
PYH1_k127_6359425_9 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008543 314.0
PYH1_k127_6441291_0 Bacterial transferase hexapeptide repeat K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 374.0
PYH1_k127_6441291_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 366.0
PYH1_k127_6441291_10 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000000002276 76.0
PYH1_k127_6441291_11 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000872 51.0
PYH1_k127_6441291_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006814 284.0
PYH1_k127_6441291_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000002196 187.0
PYH1_k127_6441291_4 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576 2.7.4.26 0.000000000000000000000000000000000000000000000004475 183.0
PYH1_k127_6441291_5 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000003707 156.0
PYH1_k127_6441291_6 Peptidyl-tRNA hydrolase PTH2 K04794,K18177 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016787,GO:0016788,GO:0019222,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0052689,GO:0060255,GO:0060548,GO:0065007,GO:0140098,GO:0140101,GO:2000209,GO:2000210,GO:2000811 3.1.1.29 0.0000000000000000000000000000002577 126.0
PYH1_k127_6441291_7 Uncharacterized protein conserved in archaea (DUF2095) - - - 0.00000000000000003043 85.0
PYH1_k127_6441291_8 exosome subunit K07581 - - 0.0000000000000009598 84.0
PYH1_k127_6441291_9 Belongs to the eukaryotic ribosomal protein eL13 family K02873 - - 0.00000000000001725 77.0
PYH1_k127_6452376_0 PP-loop family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001418 274.0
PYH1_k127_6452376_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000000000001634 218.0
PYH1_k127_6452376_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000001362 194.0
PYH1_k127_6468393_0 Uncharacterised protein family (UPF0182) K09118 - - 3.084e-266 849.0
PYH1_k127_6468393_1 isocitrate K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 490.0
PYH1_k127_6468393_10 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000008935 154.0
PYH1_k127_6468393_11 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000001231 157.0
PYH1_k127_6468393_12 Uncharacterized protein conserved in archaea (DUF2110) - - - 0.00000000000000000000000000000000008132 143.0
PYH1_k127_6468393_13 PUA domain containing protein K07398 - - 0.0000000000000000000000000000001607 129.0
PYH1_k127_6468393_14 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000008673 122.0
PYH1_k127_6468393_15 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000008358 110.0
PYH1_k127_6468393_16 Helix-turn-helix domain protein K03627 - - 0.0000000000000000001274 95.0
PYH1_k127_6468393_17 metal-dependent protease of the PAD1 JAB1 superfamily K20110 - 3.4.19.15 0.0000000000000006785 83.0
PYH1_k127_6468393_18 - - - - 0.00000000002897 70.0
PYH1_k127_6468393_19 Subtilase family - - - 0.0000000001636 74.0
PYH1_k127_6468393_2 TIGRFAM geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 354.0
PYH1_k127_6468393_20 PFAM ABC-2 type transporter K09696 - - 0.0000001946 61.0
PYH1_k127_6468393_21 Belongs to the UPF0210 family K09157 - - 0.0001207 47.0
PYH1_k127_6468393_3 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004572 280.0
PYH1_k127_6468393_4 Amino acid kinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000001527 215.0
PYH1_k127_6468393_5 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000004399 192.0
PYH1_k127_6468393_6 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000006612 192.0
PYH1_k127_6468393_7 Methionine synthase B12-binding module cap domain protein K00548,K14084 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000009786 190.0
PYH1_k127_6468393_8 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000002955 203.0
PYH1_k127_6468393_9 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000004662 166.0
PYH1_k127_6504669_0 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 449.0
PYH1_k127_6504669_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008896 439.0
PYH1_k127_6504669_10 PFAM ABC transporter related K01990 - - 0.000000000001271 72.0
PYH1_k127_6504669_2 ATP-NAD kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 414.0
PYH1_k127_6504669_3 Luciferase-like monooxygenase K14728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 342.0
PYH1_k127_6504669_4 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 322.0
PYH1_k127_6504669_5 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001054 267.0
PYH1_k127_6504669_6 Lipoate-protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000002033 269.0
PYH1_k127_6504669_7 acetyltransferase K06323 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000001351 180.0
PYH1_k127_6504669_8 Sugar (and other) transporter - - - 0.0000000000000000000000000002051 128.0
PYH1_k127_6504669_9 Phosphoserine phosphatase K01079,K05967,K07025 - 3.1.3.3 0.00000000000000005517 88.0
PYH1_k127_6584642_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000151 280.0
PYH1_k127_6584642_1 TIGRFAM dihydropteroate synthase-related protein - - - 0.000000000000000000000000000000000004774 147.0
PYH1_k127_6758077_0 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 366.0
PYH1_k127_6758077_1 Zn-dependent hydrolase, glyoxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 357.0
PYH1_k127_6758077_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 346.0
PYH1_k127_6758077_3 PFAM glycosidase, PH1107-related K20885 - 2.4.1.339,2.4.1.340 0.0000000000000000000000000000000000000000000000000000000000000000000000001051 258.0
PYH1_k127_6758077_4 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000001324 201.0
PYH1_k127_6758077_5 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000005937 185.0
PYH1_k127_6758077_6 GGDEF domain - - - 0.00000000002524 76.0
PYH1_k127_687726_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.0 1073.0
PYH1_k127_687726_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.00000001136 61.0
PYH1_k127_6883511_0 Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 328.0
PYH1_k127_6883511_1 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 327.0
PYH1_k127_6883511_2 ATPases associated with a variety of cellular activities K02006 - - 0.0000000000000000000000000000000000000000000000000000000002915 209.0
PYH1_k127_6883511_3 PFAM PAC2 family K06869 - - 0.00000000000000000000000000000000000000000002866 171.0
PYH1_k127_6883511_4 Belongs to the peptidase S16 family K06870 GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000008157 124.0
PYH1_k127_6883511_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000003525 82.0
PYH1_k127_6964558_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 605.0
PYH1_k127_6964558_1 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 445.0
PYH1_k127_6964558_2 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 391.0
PYH1_k127_6964558_3 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 347.0
PYH1_k127_6964558_4 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 340.0
PYH1_k127_6964558_5 YbaK prolyl-tRNA synthetase associated K03976 - - 0.000000000000000000001975 100.0
PYH1_k127_6964558_6 Beta-lactamase superfamily domain K03476 - - 0.000000000002462 69.0
PYH1_k127_7043193_0 ATP dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000002259 226.0
PYH1_k127_7043193_1 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.00000000000000000000000000000000000000000000000000000000000002321 225.0
PYH1_k127_7043193_2 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.0000000000000000000000000000000000000000000000000003072 188.0
PYH1_k127_7043193_3 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000003969 168.0
PYH1_k127_7043193_4 F420-0:Gamma-glutamyl ligase - - - 0.0000000000000000000000000000000000000001135 162.0
PYH1_k127_7043193_5 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000003323 93.0
PYH1_k127_7064784_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1105.0
PYH1_k127_7064784_1 Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0008964,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 504.0
PYH1_k127_7064784_10 PFAM Translin K07477 - - 0.000000000000000000000000000001188 129.0
PYH1_k127_7064784_11 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.0000000000000000000000001574 111.0
PYH1_k127_7064784_12 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000008485 97.0
PYH1_k127_7064784_13 TIGRFAM cytidyltransferase-related domain K14656 - 2.7.7.2 0.000000000004961 69.0
PYH1_k127_7064784_14 Belongs to the UPF0248 family K09715 - - 0.0000000001055 65.0
PYH1_k127_7064784_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 475.0
PYH1_k127_7064784_3 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 327.0
PYH1_k127_7064784_4 Protein of unknown function (DUF3795) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003778 261.0
PYH1_k127_7064784_5 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000005051 237.0
PYH1_k127_7064784_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000001406 207.0
PYH1_k127_7064784_7 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.7 0.000000000000000000000000000000000000000000000001916 181.0
PYH1_k127_7064784_8 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974,K18105 GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.4,6.5.1.5 0.000000000000000000000000000000000000000000000008147 181.0
PYH1_k127_7064784_9 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000001614 165.0
PYH1_k127_7150889_0 Glycine cleavage system P-protein K00281,K00282 - 1.4.4.2 1.663e-212 668.0
PYH1_k127_7150889_1 Aminotransferase class-V K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 334.0
PYH1_k127_7150889_2 Transglutaminase-like superfamily - - - 0.00000000000000002189 91.0
PYH1_k127_7157432_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 477.0
PYH1_k127_7157432_1 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006984 466.0
PYH1_k127_7157432_2 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009916 279.0
PYH1_k127_7157432_3 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002624 274.0
PYH1_k127_7157432_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000021 267.0
PYH1_k127_7157432_5 DNA polymerase Ligase (LigD) - - - 0.0000000000000000000000000000000000000000000000000003471 189.0
PYH1_k127_7157432_6 hydrolase (HAD superfamily) K01560,K07025 - 3.8.1.2 0.00000000000000000000000000000000000002181 153.0
PYH1_k127_7157432_7 Thioredoxin K03671 - - 0.000000000000000000000000000000000001563 142.0
PYH1_k127_7157432_8 YHS domain K00441 - 1.12.98.1 0.000000000262 65.0
PYH1_k127_7157432_9 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - 0.0000000009636 63.0
PYH1_k127_7186041_0 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335,K05587,K18331 - 1.12.1.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 571.0
PYH1_k127_7186041_1 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000009774 198.0
PYH1_k127_7186041_2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0000000000000000000000002017 106.0
PYH1_k127_7186041_4 bacterioferritin K03594 - 1.16.3.1 0.0000001429 63.0
PYH1_k127_7207421_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 604.0
PYH1_k127_7207421_1 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 521.0
PYH1_k127_7207421_10 hydrolase - - - 0.0000000000000000000000001962 120.0
PYH1_k127_7207421_11 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000007603 59.0
PYH1_k127_7207421_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005575 339.0
PYH1_k127_7207421_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 284.0
PYH1_k127_7207421_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000003033 231.0
PYH1_k127_7207421_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000002194 214.0
PYH1_k127_7207421_6 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000001595 212.0
PYH1_k127_7207421_7 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000008026 201.0
PYH1_k127_7207421_8 Belongs to the PRA-CH family K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000005098 178.0
PYH1_k127_7207421_9 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000001441 108.0
PYH1_k127_7283529_0 Membrane dipeptidase (Peptidase family M19) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 368.0
PYH1_k127_7283529_1 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 367.0
PYH1_k127_7283529_10 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000002322 180.0
PYH1_k127_7283529_11 Coenzyme A transferase K01040 - 2.8.3.12 0.00000000000000000000000000000000004569 144.0
PYH1_k127_7283529_12 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000007972 143.0
PYH1_k127_7283529_2 CoA binding domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 368.0
PYH1_k127_7283529_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 354.0
PYH1_k127_7283529_4 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 282.0
PYH1_k127_7283529_5 Domain of unknown function (DUF362) K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002416 290.0
PYH1_k127_7283529_6 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002179 271.0
PYH1_k127_7283529_7 Methionine synthase B12-binding module cap domain protein K00548,K14084 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000002353 212.0
PYH1_k127_7283529_8 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000009551 205.0
PYH1_k127_7283529_9 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000889 180.0
PYH1_k127_7396999_0 PFAM ABC transporter related K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000001655 224.0
PYH1_k127_7396999_1 Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000001035 128.0
PYH1_k127_7396999_2 PFAM SNARE associated Golgi protein - - - 0.00000000000000001339 89.0
PYH1_k127_7408745_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 4.994e-286 901.0
PYH1_k127_7408745_1 tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 8.868e-197 624.0
PYH1_k127_7408745_10 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000000000000000000000002014 134.0
PYH1_k127_7408745_11 Pyruvoyl-dependent arginine decarboxylase K02626 - 4.1.1.19 0.0000000000000000000000000002761 121.0
PYH1_k127_7408745_12 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000004032 87.0
PYH1_k127_7408745_13 CAAX protease self-immunity - - - 0.00000000004797 74.0
PYH1_k127_7408745_14 chromosome segregation - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0051186,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0106035,GO:1901564 - 0.00000000005586 67.0
PYH1_k127_7408745_15 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.0000001097 58.0
PYH1_k127_7408745_16 lactoylglutathione lyase activity - - - 0.000001772 52.0
PYH1_k127_7408745_2 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 486.0
PYH1_k127_7408745_3 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 432.0
PYH1_k127_7408745_4 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009558 366.0
PYH1_k127_7408745_5 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 301.0
PYH1_k127_7408745_6 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006734 280.0
PYH1_k127_7408745_7 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004445 230.0
PYH1_k127_7408745_8 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.0000000000000000000000000000000000000003882 154.0
PYH1_k127_7408745_9 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000005541 154.0
PYH1_k127_7530494_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000004985 94.0
PYH1_k127_7554608_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 1.285e-297 949.0
PYH1_k127_7554608_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006,K01007 - 2.7.9.1,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 570.0
PYH1_k127_7554608_10 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000008517 95.0
PYH1_k127_7554608_11 PFAM Rhomboid family protein - - - 0.0000000000001412 79.0
PYH1_k127_7554608_12 - - - - 0.0000000000001598 76.0
PYH1_k127_7554608_13 Transcription elongation factor Elf1 like - - - 0.000000000573 63.0
PYH1_k127_7554608_14 Sec61beta family - - - 0.0000003972 54.0
PYH1_k127_7554608_15 regulatory protein, arsR - - - 0.000611 46.0
PYH1_k127_7554608_16 - - - - 0.0008616 51.0
PYH1_k127_7554608_2 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000000000000000000000000000000000000000000000000000000000000001552 237.0
PYH1_k127_7554608_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000001177 228.0
PYH1_k127_7554608_4 XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000000000000000003561 205.0
PYH1_k127_7554608_5 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000001538 204.0
PYH1_k127_7554608_6 TIGRFAM hydrolase, TatD family K03424 - - 0.00000000000000000000000000000000000003797 152.0
PYH1_k127_7554608_7 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000001519 147.0
PYH1_k127_7554608_8 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.000000000000000000000000000004136 123.0
PYH1_k127_7554608_9 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000003564 119.0
PYH1_k127_7567985_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 342.0
PYH1_k127_7567985_1 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000004779 260.0
PYH1_k127_7567985_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006131 249.0
PYH1_k127_7567985_3 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000002579 224.0
PYH1_k127_7567985_4 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000009351 165.0
PYH1_k127_7567985_5 - - - - 0.0000000000000000000000000000000001897 142.0
PYH1_k127_7567985_6 ADP-ribose pyrophosphatase K03574 - 3.6.1.55 0.00000000000000000000000002718 112.0
PYH1_k127_7567985_7 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000000000000003361 83.0
PYH1_k127_7567985_8 serine-type endopeptidase activity - - - 0.0000000003531 72.0
PYH1_k127_7567985_9 Psort location Cytoplasmic, score - - - 0.000000306 64.0
PYH1_k127_7638339_0 CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 4.252e-197 636.0
PYH1_k127_7638339_1 AAA-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 591.0
PYH1_k127_7638339_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000795 233.0
PYH1_k127_7638339_11 c-type cytochrome biogenesis protein CcmF K02198 - - 0.00000000000000000000000000000000000000000000000000000000002811 229.0
PYH1_k127_7638339_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000405 206.0
PYH1_k127_7638339_13 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000002984 173.0
PYH1_k127_7638339_14 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000003452 160.0
PYH1_k127_7638339_15 Putative heavy-metal chelation K09138 - - 0.0000000000000000000000000000000002133 142.0
PYH1_k127_7638339_16 transcriptional regulator, AsnC family - - - 0.000000000000000000000000000000001088 135.0
PYH1_k127_7638339_17 synthase K01719 - 4.2.1.75 0.000000000000000000000000000000001922 145.0
PYH1_k127_7638339_18 COG1522 Transcriptional regulators K03718 - - 0.000000000000000000000000000231 122.0
PYH1_k127_7638339_19 synthase K02304 - 1.3.1.76,4.99.1.4 0.000000000000000000000000001176 120.0
PYH1_k127_7638339_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 462.0
PYH1_k127_7638339_20 SMART Transcription regulator, AsnC-type - - - 0.00000000000000000000000005979 122.0
PYH1_k127_7638339_21 Acetyltransferase (GNAT) domain - - - 0.000000000000006342 85.0
PYH1_k127_7638339_22 - - - - 0.0001596 53.0
PYH1_k127_7638339_3 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 454.0
PYH1_k127_7638339_4 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 426.0
PYH1_k127_7638339_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 411.0
PYH1_k127_7638339_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001734 284.0
PYH1_k127_7638339_7 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004644 274.0
PYH1_k127_7638339_8 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003332 280.0
PYH1_k127_7638339_9 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000001302 275.0
PYH1_k127_7653328_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000622 180.0
PYH1_k127_7653328_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000005692 171.0
PYH1_k127_7653328_2 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity - - - 0.000000000001189 79.0
PYH1_k127_7657379_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000203 250.0
PYH1_k127_7657379_1 COG1361 S-layer domain - - - 0.00000000000000000002106 104.0
PYH1_k127_7657379_2 ABC-type multidrug transport system, permease component K01992 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000003941 80.0
PYH1_k127_7657379_3 Transport permease protein K01992 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 - 0.00000000002235 76.0
PYH1_k127_7748685_0 TIGRFAM Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004113 252.0
PYH1_k127_7748685_1 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000001359 232.0
PYH1_k127_7748685_2 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000001834 197.0
PYH1_k127_7748685_3 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000002057 169.0
PYH1_k127_7748685_4 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000006095 128.0
PYH1_k127_7748685_5 Protein of unknown function (DUF2721) - - - 0.0004832 49.0
PYH1_k127_7770091_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 404.0
PYH1_k127_7770091_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 291.0
PYH1_k127_7770091_10 Belongs to the eukaryotic ribosomal protein eL14 family K02875 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000002981 108.0
PYH1_k127_7770091_11 Binds to the 23S rRNA K02876 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000006916 108.0
PYH1_k127_7770091_12 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000007098 110.0
PYH1_k127_7770091_13 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000002129 90.0
PYH1_k127_7770091_14 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000002713 82.0
PYH1_k127_7770091_15 Ribosomal protein S14p/S29e K02980 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000004221 73.0
PYH1_k127_7770091_16 Belongs to the eukaryotic ribosomal protein eS4 family K02987 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000134 60.0
PYH1_k127_7770091_17 membrane - - - 0.00006615 51.0
PYH1_k127_7770091_2 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000003731 241.0
PYH1_k127_7770091_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000004414 211.0
PYH1_k127_7770091_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000002553 198.0
PYH1_k127_7770091_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000003268 180.0
PYH1_k127_7770091_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000001221 176.0
PYH1_k127_7770091_7 N-terminal domain of galactosyltransferase - - - 0.0000000000000000000000000000000000000005105 162.0
PYH1_k127_7770091_8 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000002744 150.0
PYH1_k127_7770091_9 binds to the 23S rRNA K02885 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000003912 129.0
PYH1_k127_7799810_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 596.0
PYH1_k127_7799810_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.000000000000000000000000000000000000000000000000000000001292 207.0
PYH1_k127_7799810_2 Belongs to the V-ATPase 116 kDa subunit family K02123 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000197 214.0
PYH1_k127_7799810_3 Archaeal vacuolar-type H -ATPase subunit C K02119 - - 0.0000000000000000002809 100.0
PYH1_k127_7799810_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000001588 81.0
PYH1_k127_7799810_5 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000006365 74.0
PYH1_k127_7799810_6 ACT domain - - - 0.0000001297 59.0
PYH1_k127_8008522_0 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000003033 218.0
PYH1_k127_8008522_1 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000002166 184.0
PYH1_k127_821646_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 7.845e-199 631.0
PYH1_k127_821646_1 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 547.0
PYH1_k127_821646_10 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000002522 85.0
PYH1_k127_821646_11 COG COG1082 Sugar phosphate isomerases epimerases K10709 - - 0.00000000002823 74.0
PYH1_k127_821646_13 cellulase activity - - - 0.0000001456 57.0
PYH1_k127_821646_14 Domain of unknown function (DUF4440) - - - 0.0001442 51.0
PYH1_k127_821646_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 444.0
PYH1_k127_821646_3 PFAM Aminotransferase class I and II K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 421.0
PYH1_k127_821646_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 331.0
PYH1_k127_821646_5 COG3407 Mevalonate pyrophosphate decarboxylase K01597,K17942 - 4.1.1.33,4.1.1.99 0.00000000000000000000000000000000000000000000000000000000001887 218.0
PYH1_k127_821646_6 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 GO:0003674,GO:0003824,GO:0016874,GO:0016879,GO:0016881,GO:0052618 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000005286 203.0
PYH1_k127_821646_7 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.000000000000000000000000000000000002553 141.0
PYH1_k127_821646_8 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000002285 102.0
PYH1_k127_821646_9 Amidohydrolase - - - 0.0000000000000000000008426 104.0
PYH1_k127_8253112_0 Cation transporter/ATPase, N-terminus - - - 2.159e-284 901.0
PYH1_k127_8253112_1 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 366.0
PYH1_k127_8253112_2 domain protein K03499 - - 0.000000000000000000000000000000000000000000000000000000004268 205.0
PYH1_k127_8297601_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1658.0
PYH1_k127_8297601_1 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 410.0
PYH1_k127_8297601_2 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000000000001162 226.0
PYH1_k127_8297601_3 Copper-transporting ATPase K17686 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0010035,GO:0010038,GO:0010273,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061687,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:0099132,GO:1990169 3.6.3.54 0.0000000007844 62.0
PYH1_k127_8297601_4 CAAX protease self-immunity - - - 0.00000002236 61.0
PYH1_k127_8297601_5 FMN binding - - - 0.00000007265 61.0
PYH1_k127_8297601_6 - - - - 0.000003464 56.0
PYH1_k127_8345359_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 316.0
PYH1_k127_8345359_1 - - - - 0.00000000000000000000000000000000000000000000000000000008649 205.0
PYH1_k127_8345359_2 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904 - 0.0000000000000000000000000000000000000000000000000005266 191.0
PYH1_k127_8345359_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000006941 167.0
PYH1_k127_8345359_4 Glycosyl transferases group 1 K16150 - 2.4.1.11 0.0000000000000000000000000002425 128.0
PYH1_k127_8345359_5 Belongs to the eukaryotic ribosomal protein eL33 family K02917 - - 0.000000000000003364 81.0
PYH1_k127_8345359_6 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.000000000000006032 80.0
PYH1_k127_8345359_7 Protein of unknown function (DUF447) K09154 - - 0.00000001959 63.0
PYH1_k127_8345359_8 rRNA binding K02944 - - 0.0000003441 56.0
PYH1_k127_84179_0 TIGRFAM aconitate hydratase K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 364.0
PYH1_k127_84179_1 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 304.0
PYH1_k127_84179_2 TIGRFAM TIGR00268 family protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001453 262.0
PYH1_k127_84179_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000009625 198.0
PYH1_k127_84179_4 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000006138 191.0
PYH1_k127_84179_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.00000004673 64.0
PYH1_k127_845216_0 metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain K07041 - - 2.564e-210 671.0
PYH1_k127_845216_1 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 411.0
PYH1_k127_845216_2 ERCC4 domain K10896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 367.0
PYH1_k127_845216_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000001774 216.0
PYH1_k127_845216_4 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000009825 215.0
PYH1_k127_845216_5 PFAM PUA domain containing protein K07575 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000004235 108.0
PYH1_k127_845216_6 snRNP Sm proteins K04796 - - 0.00000000000000000000001626 101.0
PYH1_k127_845216_7 Binds to the 23S rRNA K02922 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000001396 98.0
PYH1_k127_855620_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 2.812e-262 812.0
PYH1_k127_855620_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 4.851e-205 645.0
PYH1_k127_855620_10 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000001022 203.0
PYH1_k127_855620_11 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000002255 198.0
PYH1_k127_855620_12 phosphoesterase, PA-phosphatase related - - - 0.0000000000000000000005106 104.0
PYH1_k127_855620_13 Winged helix-turn-helix DNA-binding - - - 0.000000000004582 76.0
PYH1_k127_855620_2 PFAM Aminotransferase class I and II K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 426.0
PYH1_k127_855620_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 346.0
PYH1_k127_855620_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006071 259.0
PYH1_k127_855620_5 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002037 242.0
PYH1_k127_855620_6 ABC transporter, ATP-binding protein K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000001693 239.0
PYH1_k127_855620_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000002482 238.0
PYH1_k127_855620_8 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000879 233.0
PYH1_k127_855620_9 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000005751 224.0
PYH1_k127_88749_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K05555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003493 265.0
PYH1_k127_88749_1 PFAM NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002731 256.0
PYH1_k127_913851_0 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 479.0
PYH1_k127_913851_1 Radical SAM K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 340.0
PYH1_k127_913851_10 TIGRFAM archaeal flagellin N-terminal-like domain - - - 0.000000000000001269 83.0
PYH1_k127_913851_11 PFAM glycosyl transferase family 39 - - - 0.000000001799 70.0
PYH1_k127_913851_12 PFAM glycosyl transferase family 39 - - - 0.00001669 57.0
PYH1_k127_913851_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002126 239.0
PYH1_k127_913851_3 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000001262 186.0
PYH1_k127_913851_4 PFAM type II secretion system K07333 - - 0.0000000000000000000000000000000000007423 150.0
PYH1_k127_913851_5 Type II secretion system K07333 - - 0.0000000000000000000000000000000000639 146.0
PYH1_k127_913851_6 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000137 141.0
PYH1_k127_913851_7 Methyltransferase FkbM domain - - - 0.000000000000000000000000004789 123.0
PYH1_k127_913851_8 Glycosyltransferase Family 4 - - - 0.000000000000000000000001919 116.0
PYH1_k127_913851_9 Winged helix-turn-helix - - - 0.00000000000000000000001784 115.0
PYH1_k127_931973_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 346.0
PYH1_k127_931973_1 UPF0292 protein - - - 0.0000000003268 66.0
PYH1_k127_955130_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006136 246.0
PYH1_k127_955130_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000007315 189.0
PYH1_k127_955130_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000009056 139.0
PYH1_k127_955130_3 anthranilate phosphoribosyltransferase activity K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.000000000000000001634 94.0
PYH1_k127_955130_4 Glyoxalase-like domain K05606 - 5.1.99.1 0.000000000000008024 80.0
PYH1_k127_955130_5 - - - - 0.0000000003129 65.0
PYH1_k127_997072_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 539.0
PYH1_k127_997072_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 491.0
PYH1_k127_997072_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 453.0
PYH1_k127_997072_3 PFAM Fmu (Sun) domain protein K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003336 282.0
PYH1_k127_997072_4 - - - - 0.000000000000000000000000000000000000000000000000000901 192.0
PYH1_k127_997072_5 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000002615 178.0
PYH1_k127_997072_6 ABC transporter K09697 - 3.6.3.7 0.000000000000000000000000000009792 123.0
PYH1_k127_997072_7 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K03658,K07466 - 3.6.4.12 0.0000000000000000000000002984 111.0
PYH1_k127_997072_8 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000007142 101.0
PYH1_k127_997072_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000001263 77.0