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Overview

ID MAG03164
Name PYH1_bin.62
Sample SMP0073
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species
Assembly information
Completeness (%) 95.02
Contamination (%) 0.03
GC content (%) 55.0
N50 (bp) 44,162
Genome size (bp) 1,597,151

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1645

Gene name Description KEGG GOs EC E-value Score Sequence
PYH1_k127_1011475_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1722.0
PYH1_k127_1011475_1 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 2.788e-273 856.0
PYH1_k127_1011475_10 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 570.0
PYH1_k127_1011475_11 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 534.0
PYH1_k127_1011475_12 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 473.0
PYH1_k127_1011475_13 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 471.0
PYH1_k127_1011475_14 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 449.0
PYH1_k127_1011475_15 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 450.0
PYH1_k127_1011475_16 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 448.0
PYH1_k127_1011475_17 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 443.0
PYH1_k127_1011475_18 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 435.0
PYH1_k127_1011475_19 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 425.0
PYH1_k127_1011475_2 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 4.213e-236 739.0
PYH1_k127_1011475_20 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 424.0
PYH1_k127_1011475_21 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 416.0
PYH1_k127_1011475_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 402.0
PYH1_k127_1011475_23 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 383.0
PYH1_k127_1011475_24 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
PYH1_k127_1011475_25 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 359.0
PYH1_k127_1011475_26 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 349.0
PYH1_k127_1011475_27 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
PYH1_k127_1011475_28 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 307.0
PYH1_k127_1011475_29 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 306.0
PYH1_k127_1011475_3 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.595e-208 661.0
PYH1_k127_1011475_30 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 307.0
PYH1_k127_1011475_31 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 301.0
PYH1_k127_1011475_32 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 299.0
PYH1_k127_1011475_33 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007501 274.0
PYH1_k127_1011475_34 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000004946 266.0
PYH1_k127_1011475_35 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000002642 263.0
PYH1_k127_1011475_36 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001578 265.0
PYH1_k127_1011475_37 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006957 249.0
PYH1_k127_1011475_38 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000004642 244.0
PYH1_k127_1011475_39 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000001425 221.0
PYH1_k127_1011475_4 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.472e-207 650.0
PYH1_k127_1011475_40 - - - - 0.0000000000000000000000000000000000000000000000000000000000003487 214.0
PYH1_k127_1011475_41 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000004102 216.0
PYH1_k127_1011475_42 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000004003 188.0
PYH1_k127_1011475_43 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000000000003156 183.0
PYH1_k127_1011475_44 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000001663 180.0
PYH1_k127_1011475_45 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000002106 176.0
PYH1_k127_1011475_46 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000006349 165.0
PYH1_k127_1011475_47 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000002142 163.0
PYH1_k127_1011475_48 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000001206 142.0
PYH1_k127_1011475_49 - - - - 0.00000000000000000000000000000000006221 139.0
PYH1_k127_1011475_5 PFAM peptidase U32 K08303 - - 3.622e-207 674.0
PYH1_k127_1011475_50 - - - - 0.0000000000000000000000000001203 118.0
PYH1_k127_1011475_51 transcription factor (CBF NF-Y) - - - 0.000000000000000000000001062 104.0
PYH1_k127_1011475_53 structural constituent of ribosome K02962 - - 0.0000000000000000001538 89.0
PYH1_k127_1011475_54 TIR domain - - - 0.00000000000000001864 87.0
PYH1_k127_1011475_55 - - - - 0.000000000000001389 79.0
PYH1_k127_1011475_56 - - - - 0.0000000000007567 74.0
PYH1_k127_1011475_57 - - - - 0.0000009088 59.0
PYH1_k127_1011475_58 - - - - 0.0002688 48.0
PYH1_k127_1011475_6 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 4.534e-202 635.0
PYH1_k127_1011475_7 PFAM PUA domain containing protein K07557 - 2.6.1.97 1.392e-200 639.0
PYH1_k127_1011475_8 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 613.0
PYH1_k127_1011475_9 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 591.0
PYH1_k127_107002_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 7.69e-320 992.0
PYH1_k127_107002_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 3.239e-242 758.0
PYH1_k127_107002_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001438 276.0
PYH1_k127_107002_11 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
PYH1_k127_107002_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000000000000000000000000002049 221.0
PYH1_k127_107002_13 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000000000000000000000008736 168.0
PYH1_k127_107002_14 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000001279 164.0
PYH1_k127_107002_15 - - - - 0.000000000000000000000000000000000000000006291 162.0
PYH1_k127_107002_16 protein possibly involved in aromatic compounds catabolism K02614 - - 0.000000000000000000000000000008832 123.0
PYH1_k127_107002_17 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000007466 91.0
PYH1_k127_107002_19 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.0000004548 53.0
PYH1_k127_107002_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.635e-226 720.0
PYH1_k127_107002_3 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 606.0
PYH1_k127_107002_4 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 585.0
PYH1_k127_107002_5 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 446.0
PYH1_k127_107002_6 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 427.0
PYH1_k127_107002_7 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 351.0
PYH1_k127_107002_8 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 347.0
PYH1_k127_107002_9 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 333.0
PYH1_k127_1221973_0 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 5.12e-221 689.0
PYH1_k127_1221973_1 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 409.0
PYH1_k127_1221973_2 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 340.0
PYH1_k127_1221973_3 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000008571 164.0
PYH1_k127_1221973_4 Thioredoxin - - - 0.0000000000000000000000000000000000000000003576 164.0
PYH1_k127_1221973_5 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000004763 83.0
PYH1_k127_1221973_6 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.000000000949 73.0
PYH1_k127_1221973_7 Nitric oxide reductase activation protein - - - 0.0007757 53.0
PYH1_k127_1284426_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 1.023e-259 807.0
PYH1_k127_1284426_1 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001516 278.0
PYH1_k127_1284426_2 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000000000000000000000004674 209.0
PYH1_k127_1284426_3 - - - - 0.0000000000000000000000127 102.0
PYH1_k127_1394673_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 407.0
PYH1_k127_1394673_1 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 402.0
PYH1_k127_1394673_2 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 368.0
PYH1_k127_1394673_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 333.0
PYH1_k127_1394673_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002033 281.0
PYH1_k127_1394673_5 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000006128 244.0
PYH1_k127_1394673_6 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000004316 169.0
PYH1_k127_1394673_7 - - - - 0.0000000000000000000000000000000000000000000006033 171.0
PYH1_k127_1394673_8 - - - - 0.00000000000000000007179 91.0
PYH1_k127_1462694_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1517.0
PYH1_k127_1462694_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1166.0
PYH1_k127_1462694_10 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 608.0
PYH1_k127_1462694_11 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 609.0
PYH1_k127_1462694_12 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 587.0
PYH1_k127_1462694_13 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 576.0
PYH1_k127_1462694_14 PFAM Aldehyde dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 569.0
PYH1_k127_1462694_15 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 565.0
PYH1_k127_1462694_16 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 547.0
PYH1_k127_1462694_17 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 546.0
PYH1_k127_1462694_18 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 526.0
PYH1_k127_1462694_19 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 514.0
PYH1_k127_1462694_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 5.524e-266 831.0
PYH1_k127_1462694_20 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 511.0
PYH1_k127_1462694_21 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 502.0
PYH1_k127_1462694_22 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 503.0
PYH1_k127_1462694_23 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007341 466.0
PYH1_k127_1462694_24 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 457.0
PYH1_k127_1462694_25 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 474.0
PYH1_k127_1462694_26 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 441.0
PYH1_k127_1462694_27 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 437.0
PYH1_k127_1462694_28 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 435.0
PYH1_k127_1462694_29 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 422.0
PYH1_k127_1462694_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.687e-264 825.0
PYH1_k127_1462694_30 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 421.0
PYH1_k127_1462694_31 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 429.0
PYH1_k127_1462694_32 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 423.0
PYH1_k127_1462694_33 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 417.0
PYH1_k127_1462694_34 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 413.0
PYH1_k127_1462694_35 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 403.0
PYH1_k127_1462694_36 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 389.0
PYH1_k127_1462694_37 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 384.0
PYH1_k127_1462694_38 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 379.0
PYH1_k127_1462694_39 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005886 377.0
PYH1_k127_1462694_4 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 3.584e-246 774.0
PYH1_k127_1462694_40 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 372.0
PYH1_k127_1462694_41 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 372.0
PYH1_k127_1462694_42 SPFH Band 7 PHB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 370.0
PYH1_k127_1462694_43 Domain of unknown function (DUF1848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 367.0
PYH1_k127_1462694_44 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 365.0
PYH1_k127_1462694_45 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 353.0
PYH1_k127_1462694_46 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 340.0
PYH1_k127_1462694_47 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 325.0
PYH1_k127_1462694_48 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 306.0
PYH1_k127_1462694_49 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 301.0
PYH1_k127_1462694_5 SMART Elongator protein 3 MiaB NifB - - - 1.193e-238 748.0
PYH1_k127_1462694_50 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
PYH1_k127_1462694_51 methanogen marker protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000577 286.0
PYH1_k127_1462694_52 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006707 280.0
PYH1_k127_1462694_53 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001652 282.0
PYH1_k127_1462694_54 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009959 272.0
PYH1_k127_1462694_55 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001398 274.0
PYH1_k127_1462694_56 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001239 270.0
PYH1_k127_1462694_57 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004169 267.0
PYH1_k127_1462694_58 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007907 277.0
PYH1_k127_1462694_59 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006101 257.0
PYH1_k127_1462694_6 AAA-like domain K06915 - - 2.414e-236 741.0
PYH1_k127_1462694_60 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003403 253.0
PYH1_k127_1462694_61 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001278 237.0
PYH1_k127_1462694_62 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000001884 221.0
PYH1_k127_1462694_63 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.000000000000000000000000000000000000000000000000000000000004742 212.0
PYH1_k127_1462694_64 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000528 204.0
PYH1_k127_1462694_65 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000000000000000000007978 190.0
PYH1_k127_1462694_66 Pas domain - - - 0.00000000000000000000000000000000000000000000000000005001 213.0
PYH1_k127_1462694_67 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000004759 190.0
PYH1_k127_1462694_68 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000006653 191.0
PYH1_k127_1462694_69 positive regulation of acetylcholine metabolic process K06910 - - 0.000000000000000000000000000000000000000000000000003472 186.0
PYH1_k127_1462694_7 Predicted membrane protein (DUF2070) K08979 - - 7.917e-205 652.0
PYH1_k127_1462694_70 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000000005464 164.0
PYH1_k127_1462694_71 PFAM RDD domain containing protein - - - 0.0000000000000000000000000000000000000000002439 163.0
PYH1_k127_1462694_72 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000009351 164.0
PYH1_k127_1462694_73 membrane protein domain - - - 0.00000000000000000000000000000000000000002089 160.0
PYH1_k127_1462694_74 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000002457 156.0
PYH1_k127_1462694_75 Pas domain - - - 0.00000000000000000000000000000000000002593 166.0
PYH1_k127_1462694_76 - - - - 0.0000000000000000000000000000000000001042 149.0
PYH1_k127_1462694_77 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000006937 130.0
PYH1_k127_1462694_78 PFAM PRC-barrel domain - - - 0.000000000000000000000000000002019 122.0
PYH1_k127_1462694_79 transcription factor (CBF NF-Y) - - - 0.000000000000000000000000002823 114.0
PYH1_k127_1462694_8 phosphoesterase RecJ domain protein - - - 2.096e-202 641.0
PYH1_k127_1462694_80 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000003905 121.0
PYH1_k127_1462694_81 Family of unknown function (DUF5350) - - - 0.000000000000000000000002727 105.0
PYH1_k127_1462694_82 PFAM TPR repeat-containing protein - - - 0.0000000000000000000007972 98.0
PYH1_k127_1462694_83 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000001973 91.0
PYH1_k127_1462694_84 - - - - 0.000000000000000002679 85.0
PYH1_k127_1462694_85 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000008994 82.0
PYH1_k127_1462694_87 - K03686 - - 0.000000000000001743 79.0
PYH1_k127_1462694_88 - K06868 - 2.5.1.73 0.0000000000009565 69.0
PYH1_k127_1462694_89 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00007111 51.0
PYH1_k127_1462694_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.131e-198 623.0
PYH1_k127_1493668_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1202.0
PYH1_k127_1493668_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.786e-209 663.0
PYH1_k127_1493668_10 2TM domain - - - 0.00000000000004039 76.0
PYH1_k127_1493668_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 7.696e-206 647.0
PYH1_k127_1493668_3 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 355.0
PYH1_k127_1493668_4 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009903 351.0
PYH1_k127_1493668_5 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 336.0
PYH1_k127_1493668_6 binding domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001219 273.0
PYH1_k127_1493668_7 META domain - - - 0.0000000000000000000000000000000000002769 151.0
PYH1_k127_1493668_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000001777 122.0
PYH1_k127_1493668_9 META domain - - - 0.0000000000000000000000000001396 124.0
PYH1_k127_1607743_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1327.0
PYH1_k127_1607743_1 DEAD DEAH box helicase domain protein K10896 - - 2.696e-300 937.0
PYH1_k127_1607743_10 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 438.0
PYH1_k127_1607743_11 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 420.0
PYH1_k127_1607743_12 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 359.0
PYH1_k127_1607743_13 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 342.0
PYH1_k127_1607743_14 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 321.0
PYH1_k127_1607743_15 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 329.0
PYH1_k127_1607743_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 321.0
PYH1_k127_1607743_17 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 323.0
PYH1_k127_1607743_18 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 294.0
PYH1_k127_1607743_19 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 293.0
PYH1_k127_1607743_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 3.256e-280 872.0
PYH1_k127_1607743_20 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003898 284.0
PYH1_k127_1607743_21 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003302 281.0
PYH1_k127_1607743_22 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002879 272.0
PYH1_k127_1607743_23 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000007959 196.0
PYH1_k127_1607743_25 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000000000000000003165 175.0
PYH1_k127_1607743_26 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000000000000000007567 176.0
PYH1_k127_1607743_27 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000003891 156.0
PYH1_k127_1607743_28 - - - - 0.00000000000000000000000000000000000003217 147.0
PYH1_k127_1607743_29 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000002056 142.0
PYH1_k127_1607743_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.571e-217 693.0
PYH1_k127_1607743_30 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000001535 145.0
PYH1_k127_1607743_31 Prokaryotic RING finger family 2 - - - 0.0000000000000000000000000004836 117.0
PYH1_k127_1607743_32 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000004192 102.0
PYH1_k127_1607743_33 PDGLE domain K02009 - - 0.00000000000000000004299 102.0
PYH1_k127_1607743_34 - - - - 0.00000000000000000009725 94.0
PYH1_k127_1607743_35 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000005606 88.0
PYH1_k127_1607743_37 - K02478 - 2.7.13.3 0.000000000000002022 79.0
PYH1_k127_1607743_38 - K02478 - 2.7.13.3 0.00000000000002892 75.0
PYH1_k127_1607743_39 defense response to virus K07061 - - 0.00000000004492 69.0
PYH1_k127_1607743_4 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 4.958e-197 620.0
PYH1_k127_1607743_5 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 561.0
PYH1_k127_1607743_6 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 528.0
PYH1_k127_1607743_7 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 500.0
PYH1_k127_1607743_8 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 481.0
PYH1_k127_1607743_9 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 463.0
PYH1_k127_1681337_0 KH, type 1, domain K07041 - - 0.0 1133.0
PYH1_k127_1681337_1 in RNase L inhibitor, RLI K06174 - - 7.161e-302 933.0
PYH1_k127_1681337_10 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
PYH1_k127_1681337_11 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 311.0
PYH1_k127_1681337_12 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 298.0
PYH1_k127_1681337_13 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 294.0
PYH1_k127_1681337_14 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 287.0
PYH1_k127_1681337_15 extracellular matrix structural constituent K01385 - 3.4.23.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001297 289.0
PYH1_k127_1681337_16 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000001446 231.0
PYH1_k127_1681337_17 Zinc-uptake complex component A periplasmic K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000008015 231.0
PYH1_k127_1681337_18 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000004097 225.0
PYH1_k127_1681337_19 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000005716 218.0
PYH1_k127_1681337_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.503e-241 764.0
PYH1_k127_1681337_20 CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000219 213.0
PYH1_k127_1681337_21 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000001245 199.0
PYH1_k127_1681337_22 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000002878 190.0
PYH1_k127_1681337_23 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000001518 172.0
PYH1_k127_1681337_24 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.000000000000000000000000000000000000000000001158 169.0
PYH1_k127_1681337_25 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000008047 164.0
PYH1_k127_1681337_26 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000001281 164.0
PYH1_k127_1681337_27 - - - - 0.0000000000000000000000000000002815 126.0
PYH1_k127_1681337_28 RNase L inhibitor, RLI - - - 0.0000000000000000000000001692 109.0
PYH1_k127_1681337_29 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000002438 74.0
PYH1_k127_1681337_3 Domain of unknown function (DUF814) - - - 4.126e-217 691.0
PYH1_k127_1681337_30 - - - - 0.00000000000003306 78.0
PYH1_k127_1681337_31 but it may be involved in stabilization of the trimeric complex - - - 0.0000000000007957 69.0
PYH1_k127_1681337_32 - K06193 - - 0.0000000001906 64.0
PYH1_k127_1681337_33 PKD domain containing protein - - - 0.000000000709 72.0
PYH1_k127_1681337_4 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007337 524.0
PYH1_k127_1681337_5 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 450.0
PYH1_k127_1681337_6 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 441.0
PYH1_k127_1681337_7 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 440.0
PYH1_k127_1681337_8 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 394.0
PYH1_k127_1681337_9 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 387.0
PYH1_k127_1689574_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.756e-258 799.0
PYH1_k127_1689574_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 1.34e-244 767.0
PYH1_k127_1689574_10 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 610.0
PYH1_k127_1689574_11 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 597.0
PYH1_k127_1689574_12 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 597.0
PYH1_k127_1689574_13 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 596.0
PYH1_k127_1689574_14 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 574.0
PYH1_k127_1689574_15 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 562.0
PYH1_k127_1689574_16 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 556.0
PYH1_k127_1689574_17 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 557.0
PYH1_k127_1689574_18 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 542.0
PYH1_k127_1689574_19 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 524.0
PYH1_k127_1689574_2 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.658e-240 745.0
PYH1_k127_1689574_20 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 520.0
PYH1_k127_1689574_21 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 513.0
PYH1_k127_1689574_22 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 481.0
PYH1_k127_1689574_23 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 485.0
PYH1_k127_1689574_24 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 443.0
PYH1_k127_1689574_25 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 444.0
PYH1_k127_1689574_26 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 438.0
PYH1_k127_1689574_27 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 436.0
PYH1_k127_1689574_28 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 414.0
PYH1_k127_1689574_29 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 406.0
PYH1_k127_1689574_3 Uncharacterized membrane protein (DUF2298) - - - 1.199e-226 723.0
PYH1_k127_1689574_30 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 405.0
PYH1_k127_1689574_31 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 386.0
PYH1_k127_1689574_32 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 370.0
PYH1_k127_1689574_33 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 368.0
PYH1_k127_1689574_34 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 347.0
PYH1_k127_1689574_35 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 341.0
PYH1_k127_1689574_36 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 312.0
PYH1_k127_1689574_37 PFAM Glycosyl transferase family 2 K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 300.0
PYH1_k127_1689574_38 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 301.0
PYH1_k127_1689574_39 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 297.0
PYH1_k127_1689574_4 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 5.918e-226 706.0
PYH1_k127_1689574_40 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 287.0
PYH1_k127_1689574_41 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 291.0
PYH1_k127_1689574_42 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 289.0
PYH1_k127_1689574_43 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 282.0
PYH1_k127_1689574_44 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001832 284.0
PYH1_k127_1689574_45 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008287 270.0
PYH1_k127_1689574_46 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007312 259.0
PYH1_k127_1689574_47 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006514 246.0
PYH1_k127_1689574_48 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000104 232.0
PYH1_k127_1689574_49 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000003812 222.0
PYH1_k127_1689574_5 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.591e-209 660.0
PYH1_k127_1689574_50 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000306 218.0
PYH1_k127_1689574_51 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000001121 225.0
PYH1_k127_1689574_52 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000008434 216.0
PYH1_k127_1689574_53 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000001864 205.0
PYH1_k127_1689574_54 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000006733 199.0
PYH1_k127_1689574_55 - - - - 0.0000000000000000000000000000000000000000000000000005362 198.0
PYH1_k127_1689574_56 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000001563 189.0
PYH1_k127_1689574_57 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000000000000000002599 169.0
PYH1_k127_1689574_58 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000419 171.0
PYH1_k127_1689574_59 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000156 161.0
PYH1_k127_1689574_6 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 3.301e-206 653.0
PYH1_k127_1689574_60 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.000000000000000000000000000000000000000005867 158.0
PYH1_k127_1689574_61 - - - - 0.000000000000000000000000000000000000001483 155.0
PYH1_k127_1689574_62 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000324 155.0
PYH1_k127_1689574_63 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000876 147.0
PYH1_k127_1689574_64 - - - - 0.000000000000000000000000000000000007241 138.0
PYH1_k127_1689574_65 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000002887 134.0
PYH1_k127_1689574_66 Peptidyl-prolyl cis-trans K01802,K03768,K03775 - 5.2.1.8 0.00000000000000000000000000000001404 135.0
PYH1_k127_1689574_67 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000003484 114.0
PYH1_k127_1689574_68 helicase activity K06915 - - 0.000000000000000000000000007026 116.0
PYH1_k127_1689574_69 Rhodanese Homology Domain - - - 0.0000000000000000000000001553 110.0
PYH1_k127_1689574_7 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 1.569e-204 642.0
PYH1_k127_1689574_70 - - - - 0.0000000000000000000000006239 109.0
PYH1_k127_1689574_71 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000003533 105.0
PYH1_k127_1689574_72 Putative small multi-drug export protein - - - 0.000000000000000002903 91.0
PYH1_k127_1689574_73 - - - - 0.000000000000000008735 89.0
PYH1_k127_1689574_74 - - - - 0.0000000000001994 72.0
PYH1_k127_1689574_75 - - - - 0.0005491 44.0
PYH1_k127_1689574_8 Involved in cell shape control K22222 - - 7.975e-197 621.0
PYH1_k127_1689574_9 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 607.0
PYH1_k127_1793478_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.424e-293 909.0
PYH1_k127_1793478_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 6.05e-285 883.0
PYH1_k127_1793478_10 Phosphate transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 512.0
PYH1_k127_1793478_11 PFAM Archaeal protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009291 499.0
PYH1_k127_1793478_12 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 475.0
PYH1_k127_1793478_13 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 429.0
PYH1_k127_1793478_14 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 424.0
PYH1_k127_1793478_15 PFAM TrkA-N domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009981 399.0
PYH1_k127_1793478_16 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 380.0
PYH1_k127_1793478_17 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009169 376.0
PYH1_k127_1793478_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 362.0
PYH1_k127_1793478_19 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 349.0
PYH1_k127_1793478_2 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.311e-281 874.0
PYH1_k127_1793478_20 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 348.0
PYH1_k127_1793478_21 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 331.0
PYH1_k127_1793478_22 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 330.0
PYH1_k127_1793478_23 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 306.0
PYH1_k127_1793478_24 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 304.0
PYH1_k127_1793478_25 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 297.0
PYH1_k127_1793478_26 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
PYH1_k127_1793478_27 amino acid transport K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004286 272.0
PYH1_k127_1793478_28 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000001057 265.0
PYH1_k127_1793478_29 4Fe-4S dicluster domain K11260,K14107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006074 257.0
PYH1_k127_1793478_3 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 1.789e-261 812.0
PYH1_k127_1793478_30 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001097 252.0
PYH1_k127_1793478_31 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001722 271.0
PYH1_k127_1793478_32 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001512 244.0
PYH1_k127_1793478_33 - K14093 - - 0.000000000000000000000000000000000000000000000000000000000000000000001413 242.0
PYH1_k127_1793478_34 V4R K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
PYH1_k127_1793478_35 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000001357 221.0
PYH1_k127_1793478_36 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000000009157 218.0
PYH1_k127_1793478_37 PFAM ABC transporter K16787 - - 0.0000000000000000000000000000000000000000000000000000000000005326 218.0
PYH1_k127_1793478_38 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000001519 220.0
PYH1_k127_1793478_39 PFAM transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000002406 217.0
PYH1_k127_1793478_4 Belongs to the RtcB family K14415 - 6.5.1.3 1.424e-228 715.0
PYH1_k127_1793478_40 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000001296 212.0
PYH1_k127_1793478_41 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000000000006705 211.0
PYH1_k127_1793478_42 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000005321 200.0
PYH1_k127_1793478_43 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000005965 192.0
PYH1_k127_1793478_44 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000000000000000000368 188.0
PYH1_k127_1793478_45 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000002547 184.0
PYH1_k127_1793478_46 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.00000000000000000000000000000000000000000000000000646 185.0
PYH1_k127_1793478_47 - - - - 0.00000000000000000000000000000000000000000000007959 179.0
PYH1_k127_1793478_48 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000000000000000000000000000000000006966 172.0
PYH1_k127_1793478_49 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000001358 150.0
PYH1_k127_1793478_5 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 6.177e-211 665.0
PYH1_k127_1793478_50 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000000000000000006185 143.0
PYH1_k127_1793478_51 PFAM Thioredoxin K03671 - - 0.0000000000000000000000000000000001144 135.0
PYH1_k127_1793478_52 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000001245 127.0
PYH1_k127_1793478_53 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000006901 128.0
PYH1_k127_1793478_54 - K00960 - 2.7.7.6 0.0000000000000000000000000003614 113.0
PYH1_k127_1793478_55 PFAM molydopterin dinucleotide-binding region K00201,K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.0000000000000000000000000006551 117.0
PYH1_k127_1793478_56 Predicted membrane protein (DUF2109) K14094 - - 0.00000000000000000000000000165 115.0
PYH1_k127_1793478_57 - - - - 0.00000000000000000000000001339 108.0
PYH1_k127_1793478_58 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000001814 108.0
PYH1_k127_1793478_59 - - - - 0.000000000000000000000001316 106.0
PYH1_k127_1793478_6 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 8.499e-203 635.0
PYH1_k127_1793478_60 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000000000000001842 101.0
PYH1_k127_1793478_61 Predicted membrane protein (DUF2107) K14096 - - 0.0000000000000000000003252 98.0
PYH1_k127_1793478_62 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.00000000000000000003706 96.0
PYH1_k127_1793478_63 Predicted membrane protein (DUF2108) K14095 - - 0.000000000001084 72.0
PYH1_k127_1793478_64 of cations and cationic drugs K11741 - - 0.0000000001112 64.0
PYH1_k127_1793478_65 - K14100 - - 0.000000004402 59.0
PYH1_k127_1793478_66 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000001711 58.0
PYH1_k127_1793478_67 - - - - 0.0000002297 59.0
PYH1_k127_1793478_68 Dinitrogenase iron-molybdenum cofactor - - - 0.000004111 50.0
PYH1_k127_1793478_69 Small multidrug resistance protein K11741 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00002191 47.0
PYH1_k127_1793478_7 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 598.0
PYH1_k127_1793478_70 - - - - 0.00003847 54.0
PYH1_k127_1793478_71 - - - - 0.0009765 48.0
PYH1_k127_1793478_8 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 557.0
PYH1_k127_1793478_9 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 501.0
PYH1_k127_192343_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1052.0
PYH1_k127_192343_1 DEAD DEAH box helicase domain protein K03725 - - 5.14e-285 889.0
PYH1_k127_192343_10 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 534.0
PYH1_k127_192343_11 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 524.0
PYH1_k127_192343_12 N-4 methylation of cytosine K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 525.0
PYH1_k127_192343_13 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 501.0
PYH1_k127_192343_14 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 464.0
PYH1_k127_192343_15 by modhmm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 488.0
PYH1_k127_192343_16 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 452.0
PYH1_k127_192343_17 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 439.0
PYH1_k127_192343_18 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 423.0
PYH1_k127_192343_19 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 396.0
PYH1_k127_192343_2 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 2.453e-280 869.0
PYH1_k127_192343_20 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 365.0
PYH1_k127_192343_21 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004873 356.0
PYH1_k127_192343_22 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 358.0
PYH1_k127_192343_23 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 323.0
PYH1_k127_192343_24 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 313.0
PYH1_k127_192343_25 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 291.0
PYH1_k127_192343_26 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004555 278.0
PYH1_k127_192343_27 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001321 255.0
PYH1_k127_192343_28 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003164 242.0
PYH1_k127_192343_29 ZPR1-related zinc finger protein K06874 - - 0.0000000000000000000000000000000000000000000000000000000000000000583 226.0
PYH1_k127_192343_3 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 3.96e-245 767.0
PYH1_k127_192343_30 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000002454 221.0
PYH1_k127_192343_31 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000003782 214.0
PYH1_k127_192343_32 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN - - - 0.000000000000000000000000000000000000000000000000000000000128 209.0
PYH1_k127_192343_33 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000001335 207.0
PYH1_k127_192343_34 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000005274 182.0
PYH1_k127_192343_35 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000001068 182.0
PYH1_k127_192343_36 - - - - 0.00000000000000000000000000000000000000000000000004168 182.0
PYH1_k127_192343_37 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000398 171.0
PYH1_k127_192343_38 cell adhesion involved in biofilm formation K02453 - - 0.0000000000000000000000000000000000000000000001611 192.0
PYH1_k127_192343_39 PFAM phosphatidate cytidylyltransferase - - - 0.00000000000000000000000000000000000000000001671 168.0
PYH1_k127_192343_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.004e-234 734.0
PYH1_k127_192343_40 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000003663 163.0
PYH1_k127_192343_41 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000000003572 155.0
PYH1_k127_192343_42 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000531 155.0
PYH1_k127_192343_43 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000000000000008374 145.0
PYH1_k127_192343_44 Zinc-ribbon containing domain - - - 0.0000000000000000000000000000000001005 133.0
PYH1_k127_192343_45 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000007912 123.0
PYH1_k127_192343_46 binds to the 23S rRNA K02922 - - 0.00000000000000000000000001916 108.0
PYH1_k127_192343_47 chorismate mutase K04093 - 5.4.99.5 0.000000000000000000000000073 111.0
PYH1_k127_192343_48 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000004693 107.0
PYH1_k127_192343_49 - K00960 - 2.7.7.6 0.000000000000000000000006759 104.0
PYH1_k127_192343_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.131e-231 722.0
PYH1_k127_192343_50 NADPH-dependent FMN reductase - - - 0.000000000000000002221 88.0
PYH1_k127_192343_51 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000003342 76.0
PYH1_k127_192343_52 PFAM PKD domain containing protein - - - 0.0000000000004568 84.0
PYH1_k127_192343_53 - - - - 0.0000000000007576 81.0
PYH1_k127_192343_54 - - - - 0.0000000002789 74.0
PYH1_k127_192343_55 membrane K09167 - - 0.0000001956 54.0
PYH1_k127_192343_6 DEAD DEAH box helicase K03724 - - 6.622e-229 730.0
PYH1_k127_192343_7 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 4.469e-223 702.0
PYH1_k127_192343_8 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.829e-208 656.0
PYH1_k127_192343_9 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 578.0
PYH1_k127_20356_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 585.0
PYH1_k127_20356_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 497.0
PYH1_k127_20356_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 329.0
PYH1_k127_20356_3 TPR repeat - - - 0.000001676 59.0
PYH1_k127_20356_4 - - - - 0.0001293 53.0
PYH1_k127_214591_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1489.0
PYH1_k127_214591_1 Heat shock 70 kDa protein K04043 - - 3.269e-318 981.0
PYH1_k127_214591_10 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 518.0
PYH1_k127_214591_11 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 466.0
PYH1_k127_214591_12 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 450.0
PYH1_k127_214591_13 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 368.0
PYH1_k127_214591_14 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 366.0
PYH1_k127_214591_15 RNA methylase K07446 - 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 362.0
PYH1_k127_214591_16 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 341.0
PYH1_k127_214591_17 40-residue YVTN family beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 349.0
PYH1_k127_214591_18 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001538 271.0
PYH1_k127_214591_19 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001423 269.0
PYH1_k127_214591_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 6.416e-316 978.0
PYH1_k127_214591_20 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000000000000000000000000000000000006355 206.0
PYH1_k127_214591_21 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000008248 215.0
PYH1_k127_214591_22 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000000000001911 193.0
PYH1_k127_214591_23 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000001336 187.0
PYH1_k127_214591_24 DNA ligase D, 3-phosphoesterase domain - - - 0.00000000000000000000000000000000000000000000000000198 184.0
PYH1_k127_214591_25 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000002143 156.0
PYH1_k127_214591_26 COG0328 Ribonuclease HI K03469 - 3.1.26.4 0.000000000000000000000000000005503 124.0
PYH1_k127_214591_27 fibronectin type III domain protein - - - 0.0000000000000000000000000003903 131.0
PYH1_k127_214591_28 - - - - 0.0000000000000000000000000006991 115.0
PYH1_k127_214591_29 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000009735 117.0
PYH1_k127_214591_3 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 6.154e-291 900.0
PYH1_k127_214591_30 - - - - 0.0000000000000000118 84.0
PYH1_k127_214591_31 S-layer homology domain - - - 0.00000000000002097 87.0
PYH1_k127_214591_32 Uncharacterised ArCR, COG2043 - - - 0.000002557 51.0
PYH1_k127_214591_33 Uncharacterised ArCR, COG2043 - - - 0.00004456 48.0
PYH1_k127_214591_34 CARDB - - - 0.00007458 55.0
PYH1_k127_214591_4 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 3.202e-238 744.0
PYH1_k127_214591_5 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 1.617e-229 719.0
PYH1_k127_214591_6 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 1.302e-198 632.0
PYH1_k127_214591_7 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 609.0
PYH1_k127_214591_8 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 535.0
PYH1_k127_214591_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 529.0
PYH1_k127_2528132_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 2.841e-198 626.0
PYH1_k127_2528132_1 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 447.0
PYH1_k127_2528132_2 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 317.0
PYH1_k127_2528132_4 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003633 241.0
PYH1_k127_2528132_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000004944 136.0
PYH1_k127_2528132_6 META domain - - - 0.00000004023 61.0
PYH1_k127_2528132_7 PcfJ-like protein - - - 0.0008481 45.0
PYH1_k127_2608000_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1010.0
PYH1_k127_2608000_1 2Fe-2S iron-sulfur cluster binding domain - - - 5.649e-302 938.0
PYH1_k127_2608000_10 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 311.0
PYH1_k127_2608000_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005856 268.0
PYH1_k127_2608000_12 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001471 248.0
PYH1_k127_2608000_13 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000001609 162.0
PYH1_k127_2608000_14 - - - - 0.000000000000000000000000000000000000000005215 162.0
PYH1_k127_2608000_15 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000789 94.0
PYH1_k127_2608000_16 - - - - 0.0000000000000001724 83.0
PYH1_k127_2608000_17 - - - - 0.00000000000002 76.0
PYH1_k127_2608000_18 - - - - 0.00000000002738 67.0
PYH1_k127_2608000_19 - - - - 0.0000000002519 65.0
PYH1_k127_2608000_2 Nitrogenase component 1 type Oxidoreductase K02587 - - 1.211e-274 848.0
PYH1_k127_2608000_20 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.00000002525 55.0
PYH1_k127_2608000_21 - - - - 0.0000005956 57.0
PYH1_k127_2608000_22 VIT family - - - 0.000002079 57.0
PYH1_k127_2608000_3 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 2.531e-241 752.0
PYH1_k127_2608000_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 596.0
PYH1_k127_2608000_5 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 486.0
PYH1_k127_2608000_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 451.0
PYH1_k127_2608000_7 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 432.0
PYH1_k127_2608000_8 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 419.0
PYH1_k127_2608000_9 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 396.0
PYH1_k127_2669841_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 5.352e-233 734.0
PYH1_k127_2669841_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 364.0
PYH1_k127_2669841_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 287.0
PYH1_k127_2669841_3 Flavodoxin - - - 0.000000000000000000000000000000000000000004846 160.0
PYH1_k127_2669841_4 - - - - 0.00000000000000000000000000000000007983 136.0
PYH1_k127_2669841_5 - - - - 0.00000000001604 70.0
PYH1_k127_2678911_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 365.0
PYH1_k127_2678911_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000008121 246.0
PYH1_k127_2678911_2 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000001997 227.0
PYH1_k127_2678911_4 Multicopper K06324 - 1.16.3.3 0.000000000000000002249 98.0
PYH1_k127_2678911_5 Domain of unknown function (DUF4418) - - - 0.00000004816 58.0
PYH1_k127_3177777_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 9.954e-253 787.0
PYH1_k127_3177777_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 2.429e-242 756.0
PYH1_k127_3177777_10 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 377.0
PYH1_k127_3177777_11 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 363.0
PYH1_k127_3177777_12 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 364.0
PYH1_k127_3177777_13 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 360.0
PYH1_k127_3177777_14 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 355.0
PYH1_k127_3177777_15 Uncharacterised conserved protein (DUF2156) K01163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
PYH1_k127_3177777_16 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 325.0
PYH1_k127_3177777_17 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 296.0
PYH1_k127_3177777_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005656 292.0
PYH1_k127_3177777_19 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004814 271.0
PYH1_k127_3177777_2 AMP-binding enzyme - - - 5.783e-211 664.0
PYH1_k127_3177777_20 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009365 263.0
PYH1_k127_3177777_21 COG2041 Sulfite oxidase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001991 263.0
PYH1_k127_3177777_22 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001375 254.0
PYH1_k127_3177777_23 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004786 244.0
PYH1_k127_3177777_24 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008956 242.0
PYH1_k127_3177777_25 Integral membrane protein DUF106 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001335 241.0
PYH1_k127_3177777_26 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000021 238.0
PYH1_k127_3177777_27 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000004074 237.0
PYH1_k127_3177777_28 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000006829 233.0
PYH1_k127_3177777_29 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000000008799 232.0
PYH1_k127_3177777_3 PFAM Radical SAM domain protein K06871 - - 4.908e-196 616.0
PYH1_k127_3177777_30 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000001459 228.0
PYH1_k127_3177777_31 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000000000000000005475 222.0
PYH1_k127_3177777_32 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000008358 217.0
PYH1_k127_3177777_33 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000003935 217.0
PYH1_k127_3177777_34 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000001059 209.0
PYH1_k127_3177777_35 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000001959 194.0
PYH1_k127_3177777_36 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000000000000000004129 185.0
PYH1_k127_3177777_37 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000005482 181.0
PYH1_k127_3177777_38 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000001945 175.0
PYH1_k127_3177777_39 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000003152 170.0
PYH1_k127_3177777_4 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 9.391e-196 613.0
PYH1_k127_3177777_40 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000000000000000000959 162.0
PYH1_k127_3177777_41 PFAM Ribosomal protein K02912 - - 0.000000000000000000000000000000000000000007036 157.0
PYH1_k127_3177777_42 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000003432 118.0
PYH1_k127_3177777_43 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000000000002581 106.0
PYH1_k127_3177777_44 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.0000000000000000000000008072 104.0
PYH1_k127_3177777_45 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000000000002181 105.0
PYH1_k127_3177777_46 PBS lyase HEAT-like repeat - - - 0.00000000000004522 79.0
PYH1_k127_3177777_47 Domain of unknown function (DUF3821) - - - 0.00000006605 54.0
PYH1_k127_3177777_48 - - - - 0.0002146 49.0
PYH1_k127_3177777_5 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 588.0
PYH1_k127_3177777_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 536.0
PYH1_k127_3177777_7 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 486.0
PYH1_k127_3177777_8 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 454.0
PYH1_k127_3177777_9 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 417.0
PYH1_k127_3436769_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1024.0
PYH1_k127_3436769_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001281 230.0
PYH1_k127_3436769_2 serine-type endopeptidase activity - - - 0.000000000000000000000000000000000000000007303 175.0
PYH1_k127_3436769_3 HEAT repeats - - - 0.000000000000000000000000000000007541 133.0
PYH1_k127_3436769_4 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.0000000000000003766 93.0
PYH1_k127_3436769_5 Domain of unknown function DUF11 - - - 0.0000000000003989 83.0
PYH1_k127_3436769_6 COG1520 FOG WD40-like repeat - - - 0.000000005073 69.0
PYH1_k127_3487413_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1404.0
PYH1_k127_3487413_1 PFAM PilT protein domain protein K06865 - - 3.807e-303 939.0
PYH1_k127_3487413_10 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000003624 269.0
PYH1_k127_3487413_11 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000001855 249.0
PYH1_k127_3487413_12 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000003099 193.0
PYH1_k127_3487413_13 Roadblock LC7 K07131 - - 0.0000000000000000000000000000000000000000000000000001555 186.0
PYH1_k127_3487413_14 Protein of unknown function (DUF473) K09135 - - 0.000000000000000000000000000000000000000002447 160.0
PYH1_k127_3487413_15 COG1403 Restriction endonuclease K10726 - - 0.000000000000000000000000000000000000000004846 160.0
PYH1_k127_3487413_16 - - - - 0.00000000000000000000000000000000000000007051 158.0
PYH1_k127_3487413_17 - - - - 0.00000000000000000000000000000000005296 136.0
PYH1_k127_3487413_18 Roadblock LC7 - - - 0.000000000000000000000000000004726 125.0
PYH1_k127_3487413_19 - - - - 0.00000000000000000000000002926 116.0
PYH1_k127_3487413_2 PFAM type II secretion system protein E K07332 - - 9.429e-276 865.0
PYH1_k127_3487413_20 transcription termination protein NusA K02600 - - 0.00000000000009111 71.0
PYH1_k127_3487413_21 - - - - 0.0000002532 59.0
PYH1_k127_3487413_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 6.903e-274 853.0
PYH1_k127_3487413_4 PFAM 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 603.0
PYH1_k127_3487413_5 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 575.0
PYH1_k127_3487413_6 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 377.0
PYH1_k127_3487413_7 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 369.0
PYH1_k127_3487413_8 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 356.0
PYH1_k127_3487413_9 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 355.0
PYH1_k127_3505850_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0 1261.0
PYH1_k127_3505850_1 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 9.11e-233 741.0
PYH1_k127_3505850_10 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000002272 146.0
PYH1_k127_3505850_11 SpoVT / AbrB like domain - - - 0.000000000000000000000000001442 114.0
PYH1_k127_3505850_12 - - - - 0.000000000000000000000005495 108.0
PYH1_k127_3505850_2 PFAM amino acid permease-associated region K20265 - - 6.201e-223 699.0
PYH1_k127_3505850_3 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 416.0
PYH1_k127_3505850_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 379.0
PYH1_k127_3505850_5 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 338.0
PYH1_k127_3505850_6 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 308.0
PYH1_k127_3505850_7 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 309.0
PYH1_k127_3505850_8 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000476 216.0
PYH1_k127_3505850_9 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000004026 178.0
PYH1_k127_3675727_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1401.0
PYH1_k127_3675727_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1296.0
PYH1_k127_3675727_10 Highly conserved protein containing a thioredoxin domain K06888 - - 2.381e-210 675.0
PYH1_k127_3675727_100 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000001795 195.0
PYH1_k127_3675727_101 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000002033 203.0
PYH1_k127_3675727_102 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000007272 193.0
PYH1_k127_3675727_103 Small multi-drug export protein - - - 0.0000000000000000000000000000000000000000000000000001017 194.0
PYH1_k127_3675727_104 NTPase - - - 0.000000000000000000000000000000000000000000000000003863 186.0
PYH1_k127_3675727_105 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000001122 184.0
PYH1_k127_3675727_106 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000000000000000000000000002347 184.0
PYH1_k127_3675727_107 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000004783 182.0
PYH1_k127_3675727_108 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000001346 189.0
PYH1_k127_3675727_109 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000201 179.0
PYH1_k127_3675727_11 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 4.491e-199 634.0
PYH1_k127_3675727_110 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000641 179.0
PYH1_k127_3675727_111 Cupin domain - - - 0.0000000000000000000000000000000000000000000000007045 184.0
PYH1_k127_3675727_112 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.000000000000000000000000000000000000000000000005754 178.0
PYH1_k127_3675727_113 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000005517 174.0
PYH1_k127_3675727_114 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.00000000000000000000000000000000000000000000005974 175.0
PYH1_k127_3675727_115 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000000000003112 171.0
PYH1_k127_3675727_116 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000000003396 171.0
PYH1_k127_3675727_117 - - - - 0.00000000000000000000000000000000000000000001272 166.0
PYH1_k127_3675727_118 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000004093 161.0
PYH1_k127_3675727_119 - - - - 0.0000000000000000000000000000000000000000004095 166.0
PYH1_k127_3675727_12 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 7.536e-199 626.0
PYH1_k127_3675727_120 Belongs to the UPF0216 family K09737 - - 0.000000000000000000000000000000000000000001191 163.0
PYH1_k127_3675727_121 - - - - 0.00000000000000000000000000000000000000005842 161.0
PYH1_k127_3675727_122 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000007592 153.0
PYH1_k127_3675727_123 - - - - 0.0000000000000000000000000000000000000003564 152.0
PYH1_k127_3675727_124 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000001099 154.0
PYH1_k127_3675727_125 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000000000000000001316 147.0
PYH1_k127_3675727_126 Hydrogenase maturation protease K08315 - 3.4.23.51 0.0000000000000000000000000000000000003495 147.0
PYH1_k127_3675727_127 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000007721 145.0
PYH1_k127_3675727_128 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000004319 149.0
PYH1_k127_3675727_129 - - - - 0.000000000000000000000000000000000008363 149.0
PYH1_k127_3675727_13 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 6.406e-196 617.0
PYH1_k127_3675727_130 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000003097 137.0
PYH1_k127_3675727_131 Cobalamin biosynthesis protein CbiG K02189 - 3.7.1.12 0.0000000000000000000000000000000000368 145.0
PYH1_k127_3675727_132 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000003879 137.0
PYH1_k127_3675727_133 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000000000000001501 136.0
PYH1_k127_3675727_134 zinc finger, SWIM - - - 0.000000000000000000000000000000006976 130.0
PYH1_k127_3675727_135 small multi-drug export - - - 0.00000000000000000000000000000002132 133.0
PYH1_k127_3675727_136 - - - - 0.00000000000000000000000000000003915 131.0
PYH1_k127_3675727_137 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000000001048 127.0
PYH1_k127_3675727_138 - - - - 0.00000000000000000000000000000104 124.0
PYH1_k127_3675727_139 - - - - 0.00000000000000000000000000004224 124.0
PYH1_k127_3675727_14 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 1.638e-194 613.0
PYH1_k127_3675727_140 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000002885 119.0
PYH1_k127_3675727_141 - - - - 0.000000000000000000000000008502 119.0
PYH1_k127_3675727_142 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000000001355 113.0
PYH1_k127_3675727_143 - - - - 0.00000000000000000000000002473 115.0
PYH1_k127_3675727_144 META domain - - - 0.00000000000000000000000005901 112.0
PYH1_k127_3675727_145 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.0000000000000000000000001584 109.0
PYH1_k127_3675727_146 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000002832 108.0
PYH1_k127_3675727_147 - - - - 0.0000000000000000000000005132 115.0
PYH1_k127_3675727_148 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.0000000000000000000000008377 106.0
PYH1_k127_3675727_149 - - - - 0.000000000000000000000002585 104.0
PYH1_k127_3675727_15 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 607.0
PYH1_k127_3675727_150 CRS1_YhbY K07574 - - 0.0000000000000000000001528 99.0
PYH1_k127_3675727_151 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000007816 106.0
PYH1_k127_3675727_152 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000746 94.0
PYH1_k127_3675727_153 Domain of unknown function (DUF4040) - - - 0.0000000000000000000103 96.0
PYH1_k127_3675727_154 - - - - 0.0000000000000000002035 90.0
PYH1_k127_3675727_155 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000009148 87.0
PYH1_k127_3675727_156 PFAM PKD domain containing protein - - - 0.000000000000000001789 96.0
PYH1_k127_3675727_157 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000002144 85.0
PYH1_k127_3675727_158 PFAM Uncharacterised conserved protein UCP006577 - - - 0.00000000000000001965 85.0
PYH1_k127_3675727_159 Membrane bound hydrogenase - - - 0.00000000000000034 81.0
PYH1_k127_3675727_16 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 603.0
PYH1_k127_3675727_161 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.00000000000004952 75.0
PYH1_k127_3675727_162 - - - - 0.0000000000000906 76.0
PYH1_k127_3675727_163 - - - - 0.00000001081 57.0
PYH1_k127_3675727_164 - - - - 0.0000003868 61.0
PYH1_k127_3675727_165 TPR repeat Sel1-like repeat Tetratricopeptide TPR_3 Tetratricopeptide TPR_2 - - - 0.00002851 55.0
PYH1_k127_3675727_17 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 597.0
PYH1_k127_3675727_18 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 596.0
PYH1_k127_3675727_19 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 569.0
PYH1_k127_3675727_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1249.0
PYH1_k127_3675727_20 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 552.0
PYH1_k127_3675727_21 TGS domain protein K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 548.0
PYH1_k127_3675727_22 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 549.0
PYH1_k127_3675727_23 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 542.0
PYH1_k127_3675727_24 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 527.0
PYH1_k127_3675727_25 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 526.0
PYH1_k127_3675727_26 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 527.0
PYH1_k127_3675727_27 PFAM DNA photolyase K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 510.0
PYH1_k127_3675727_28 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 498.0
PYH1_k127_3675727_29 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 470.0
PYH1_k127_3675727_3 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.289e-303 954.0
PYH1_k127_3675727_30 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 460.0
PYH1_k127_3675727_31 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 430.0
PYH1_k127_3675727_32 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 422.0
PYH1_k127_3675727_33 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 420.0
PYH1_k127_3675727_34 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 422.0
PYH1_k127_3675727_35 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 429.0
PYH1_k127_3675727_36 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008212 413.0
PYH1_k127_3675727_37 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 412.0
PYH1_k127_3675727_38 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 402.0
PYH1_k127_3675727_39 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 401.0
PYH1_k127_3675727_4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.722e-271 842.0
PYH1_k127_3675727_40 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 391.0
PYH1_k127_3675727_41 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 392.0
PYH1_k127_3675727_42 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 368.0
PYH1_k127_3675727_43 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 368.0
PYH1_k127_3675727_44 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 367.0
PYH1_k127_3675727_45 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009152 352.0
PYH1_k127_3675727_46 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 340.0
PYH1_k127_3675727_47 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
PYH1_k127_3675727_48 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009165 352.0
PYH1_k127_3675727_49 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 338.0
PYH1_k127_3675727_5 amino acid K03294 - - 1.291e-266 836.0
PYH1_k127_3675727_50 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 331.0
PYH1_k127_3675727_51 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 323.0
PYH1_k127_3675727_52 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 328.0
PYH1_k127_3675727_53 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 317.0
PYH1_k127_3675727_54 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 318.0
PYH1_k127_3675727_55 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 311.0
PYH1_k127_3675727_56 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 300.0
PYH1_k127_3675727_57 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 297.0
PYH1_k127_3675727_58 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 311.0
PYH1_k127_3675727_59 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 307.0
PYH1_k127_3675727_6 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.532e-250 784.0
PYH1_k127_3675727_60 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 293.0
PYH1_k127_3675727_61 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 293.0
PYH1_k127_3675727_62 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000011 287.0
PYH1_k127_3675727_63 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 281.0
PYH1_k127_3675727_64 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000216 272.0
PYH1_k127_3675727_65 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005282 274.0
PYH1_k127_3675727_66 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007806 273.0
PYH1_k127_3675727_67 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001084 270.0
PYH1_k127_3675727_68 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002708 271.0
PYH1_k127_3675727_69 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009133 269.0
PYH1_k127_3675727_7 PFAM CBS domain - - - 1.924e-250 780.0
PYH1_k127_3675727_70 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000001076 267.0
PYH1_k127_3675727_71 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000001249 262.0
PYH1_k127_3675727_72 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000016 259.0
PYH1_k127_3675727_73 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000000002714 253.0
PYH1_k127_3675727_74 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000005169 255.0
PYH1_k127_3675727_75 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18023 - 1.12.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006562 251.0
PYH1_k127_3675727_76 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000201 249.0
PYH1_k127_3675727_77 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005976 250.0
PYH1_k127_3675727_78 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004558 241.0
PYH1_k127_3675727_79 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005759 246.0
PYH1_k127_3675727_8 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 7.818e-228 713.0
PYH1_k127_3675727_80 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000001277 244.0
PYH1_k127_3675727_81 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000004489 242.0
PYH1_k127_3675727_82 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
PYH1_k127_3675727_83 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000000000000000000000000000000001323 238.0
PYH1_k127_3675727_84 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000000000001175 236.0
PYH1_k127_3675727_85 Domain of unknown function (DUF1724) - - - 0.00000000000000000000000000000000000000000000000000000000000000001005 233.0
PYH1_k127_3675727_86 PFAM Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000103 238.0
PYH1_k127_3675727_87 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000000001611 226.0
PYH1_k127_3675727_88 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000001792 228.0
PYH1_k127_3675727_89 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000003122 226.0
PYH1_k127_3675727_9 Proton-conducting membrane transporter K05568 - - 1.62e-224 706.0
PYH1_k127_3675727_90 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000000756 222.0
PYH1_k127_3675727_91 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000006301 222.0
PYH1_k127_3675727_92 archaeal Zn-finger protein - - - 0.000000000000000000000000000000000000000000000000000000000003136 214.0
PYH1_k127_3675727_93 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000000000003537 216.0
PYH1_k127_3675727_94 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.000000000000000000000000000000000000000000000000000000000004118 214.0
PYH1_k127_3675727_95 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000004706 207.0
PYH1_k127_3675727_96 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000000000000008674 207.0
PYH1_k127_3675727_97 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.000000000000000000000000000000000000000000000000000000006604 200.0
PYH1_k127_3675727_98 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000001618 199.0
PYH1_k127_3675727_99 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000318 207.0
PYH1_k127_3790083_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.71e-209 655.0
PYH1_k127_3790083_1 LOR SDH bifunctional enzyme conserved - - - 1.896e-199 630.0
PYH1_k127_3790083_10 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000000000065 235.0
PYH1_k127_3790083_11 - - - - 0.000000000000000000000000000000000000000000000000000000000001049 224.0
PYH1_k127_3790083_12 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000004194 155.0
PYH1_k127_3790083_13 - - - - 0.00000000000000000000000000000000000000003707 156.0
PYH1_k127_3790083_14 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000000000000004834 134.0
PYH1_k127_3790083_15 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000001309 101.0
PYH1_k127_3790083_16 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000002922 100.0
PYH1_k127_3790083_17 signal transduction protein with CBS domains - - - 0.000000000000000000001087 105.0
PYH1_k127_3790083_18 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000001628 92.0
PYH1_k127_3790083_19 signal transduction protein with CBS domains - - - 0.000000000000000007141 94.0
PYH1_k127_3790083_2 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 535.0
PYH1_k127_3790083_20 - - - - 0.00000000001161 66.0
PYH1_k127_3790083_21 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00176 - 1.2.7.3 0.0000000002981 64.0
PYH1_k127_3790083_22 protein kinase activity - - - 0.00002267 55.0
PYH1_k127_3790083_3 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009307 505.0
PYH1_k127_3790083_4 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 444.0
PYH1_k127_3790083_5 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 435.0
PYH1_k127_3790083_6 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 417.0
PYH1_k127_3790083_7 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 375.0
PYH1_k127_3790083_8 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 355.0
PYH1_k127_3790083_9 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009402 329.0
PYH1_k127_3834270_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1271.0
PYH1_k127_3834270_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 6.229e-306 945.0
PYH1_k127_3834270_10 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 566.0
PYH1_k127_3834270_11 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 548.0
PYH1_k127_3834270_12 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 531.0
PYH1_k127_3834270_13 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 481.0
PYH1_k127_3834270_14 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 473.0
PYH1_k127_3834270_15 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 460.0
PYH1_k127_3834270_16 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 456.0
PYH1_k127_3834270_17 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 436.0
PYH1_k127_3834270_18 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 427.0
PYH1_k127_3834270_19 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 403.0
PYH1_k127_3834270_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.159e-285 892.0
PYH1_k127_3834270_20 Tripartite tricarboxylate transporter TctA family K08971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 406.0
PYH1_k127_3834270_21 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 398.0
PYH1_k127_3834270_22 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 378.0
PYH1_k127_3834270_23 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 376.0
PYH1_k127_3834270_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 379.0
PYH1_k127_3834270_25 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 378.0
PYH1_k127_3834270_26 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 369.0
PYH1_k127_3834270_27 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 371.0
PYH1_k127_3834270_28 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 364.0
PYH1_k127_3834270_29 methylase K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 350.0
PYH1_k127_3834270_3 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 1.28e-247 773.0
PYH1_k127_3834270_30 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 344.0
PYH1_k127_3834270_31 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 339.0
PYH1_k127_3834270_32 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 334.0
PYH1_k127_3834270_33 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 341.0
PYH1_k127_3834270_34 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 328.0
PYH1_k127_3834270_35 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 329.0
PYH1_k127_3834270_36 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 318.0
PYH1_k127_3834270_37 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 302.0
PYH1_k127_3834270_38 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 288.0
PYH1_k127_3834270_39 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004426 281.0
PYH1_k127_3834270_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 5.393e-242 756.0
PYH1_k127_3834270_40 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002859 270.0
PYH1_k127_3834270_41 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005217 269.0
PYH1_k127_3834270_42 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002468 259.0
PYH1_k127_3834270_43 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004729 267.0
PYH1_k127_3834270_44 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003839 251.0
PYH1_k127_3834270_45 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008288 244.0
PYH1_k127_3834270_46 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000000000000000000000000000177 242.0
PYH1_k127_3834270_47 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000002853 235.0
PYH1_k127_3834270_48 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000000000000000000000000000000001144 224.0
PYH1_k127_3834270_49 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000006193 222.0
PYH1_k127_3834270_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 7.282e-242 759.0
PYH1_k127_3834270_50 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000002899 212.0
PYH1_k127_3834270_51 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000001914 207.0
PYH1_k127_3834270_52 - - - - 0.00000000000000000000000000000000000000000000000000000004337 205.0
PYH1_k127_3834270_53 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000004247 192.0
PYH1_k127_3834270_54 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000007832 181.0
PYH1_k127_3834270_55 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000006442 190.0
PYH1_k127_3834270_56 Ras family K06945 - - 0.000000000000000000000000000000000000000000000009933 177.0
PYH1_k127_3834270_57 Coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.00000000000000000000000000000000000000000000001024 178.0
PYH1_k127_3834270_58 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000005517 174.0
PYH1_k127_3834270_59 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000009819 153.0
PYH1_k127_3834270_6 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 3.757e-240 747.0
PYH1_k127_3834270_60 PFAM PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000005902 150.0
PYH1_k127_3834270_61 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000000000001711 139.0
PYH1_k127_3834270_62 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000003476 140.0
PYH1_k127_3834270_63 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000001141 132.0
PYH1_k127_3834270_64 protein conserved in archaea - - - 0.00000000000000000000000000000001247 129.0
PYH1_k127_3834270_65 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000000003698 123.0
PYH1_k127_3834270_66 Transcriptional regulator K07108 - - 0.000000000000000000000000000001001 124.0
PYH1_k127_3834270_67 transcriptional regulators K03724 - - 0.0000000000000000000000000003484 114.0
PYH1_k127_3834270_68 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000000000002319 113.0
PYH1_k127_3834270_69 PFAM Yip1 domain - - - 0.000000000000000000000000004879 118.0
PYH1_k127_3834270_7 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 6.06e-224 699.0
PYH1_k127_3834270_70 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00000000000000000000000006402 109.0
PYH1_k127_3834270_71 PFAM Protein kinase domain - - - 0.000000000000000000000001042 115.0
PYH1_k127_3834270_72 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000000004577 98.0
PYH1_k127_3834270_73 - - - - 0.00000000000000000000005033 106.0
PYH1_k127_3834270_74 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000003582 94.0
PYH1_k127_3834270_75 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000000008115 94.0
PYH1_k127_3834270_76 - - - - 0.00000000000000009004 81.0
PYH1_k127_3834270_77 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000004594 82.0
PYH1_k127_3834270_78 nucleic acid binding OB-fold tRNA helicase-type - - - 0.000000000000003404 80.0
PYH1_k127_3834270_79 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000423 75.0
PYH1_k127_3834270_8 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 7.985e-215 672.0
PYH1_k127_3834270_80 - - - - 0.00000000002268 68.0
PYH1_k127_3834270_9 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 618.0
PYH1_k127_4009542_0 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000000000000000003144 209.0
PYH1_k127_4009542_1 Fe-S-cluster oxidoreductase - - - 0.000000000000000000000000000000000000000000001825 167.0
PYH1_k127_4009542_2 PFAM PKD domain - - - 0.000000000000000000000000002213 126.0
PYH1_k127_4024249_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1602.0
PYH1_k127_4024249_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1071.0
PYH1_k127_4024249_10 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 392.0
PYH1_k127_4024249_11 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 359.0
PYH1_k127_4024249_12 phosphohydrolase (DHH superfamily) K07097 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006365 358.0
PYH1_k127_4024249_13 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 289.0
PYH1_k127_4024249_14 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004145 262.0
PYH1_k127_4024249_15 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000001897 241.0
PYH1_k127_4024249_16 COG0590 Cytosine adenosine deaminases K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
PYH1_k127_4024249_17 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000000000000000002849 229.0
PYH1_k127_4024249_18 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000003445 228.0
PYH1_k127_4024249_19 - - - - 0.00000000000000000000000000000000000000000000000000002163 195.0
PYH1_k127_4024249_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1045.0
PYH1_k127_4024249_20 Tellurite resistance protein TerB - - - 0.000000000000000000000000000000000000000000000000005492 184.0
PYH1_k127_4024249_21 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000000000000006141 157.0
PYH1_k127_4024249_22 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000000000000000001967 136.0
PYH1_k127_4024249_23 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000001603 94.0
PYH1_k127_4024249_3 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 3.313e-314 965.0
PYH1_k127_4024249_4 Conserved region in glutamate synthase - - - 4.223e-294 908.0
PYH1_k127_4024249_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 9.958e-205 641.0
PYH1_k127_4024249_6 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 537.0
PYH1_k127_4024249_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 521.0
PYH1_k127_4024249_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 447.0
PYH1_k127_4024249_9 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 401.0
PYH1_k127_4103424_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 563.0
PYH1_k127_4103424_1 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 511.0
PYH1_k127_4103424_10 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 388.0
PYH1_k127_4103424_11 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 301.0
PYH1_k127_4103424_12 Met-10+ like-protein K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 273.0
PYH1_k127_4103424_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002829 275.0
PYH1_k127_4103424_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001652 270.0
PYH1_k127_4103424_15 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008658 246.0
PYH1_k127_4103424_16 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000023 186.0
PYH1_k127_4103424_17 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000002378 164.0
PYH1_k127_4103424_18 - - - - 0.00000000000000000000000000000000000002249 160.0
PYH1_k127_4103424_19 - - - - 0.0000000000000000000000000006715 117.0
PYH1_k127_4103424_2 Pas domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 512.0
PYH1_k127_4103424_20 Regulatory protein MarR - - - 0.00000000000000000000000001371 114.0
PYH1_k127_4103424_21 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000001346 105.0
PYH1_k127_4103424_22 PspC domain K03973 - - 0.0000000000000000006473 88.0
PYH1_k127_4103424_23 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000000000007101 92.0
PYH1_k127_4103424_24 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000008698 93.0
PYH1_k127_4103424_25 Ion channel - - - 0.000000000000001602 89.0
PYH1_k127_4103424_26 - - - - 0.000000000000001822 79.0
PYH1_k127_4103424_27 - - - - 0.0000000000001343 81.0
PYH1_k127_4103424_28 TIR domain - - - 0.000000000005337 72.0
PYH1_k127_4103424_29 PFAM TPR repeat-containing protein - - - 0.00000000001109 71.0
PYH1_k127_4103424_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 463.0
PYH1_k127_4103424_30 Outer membrane receptor - - - 0.00000004316 65.0
PYH1_k127_4103424_32 deoxyhypusine monooxygenase activity K06921 - - 0.00001543 53.0
PYH1_k127_4103424_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 445.0
PYH1_k127_4103424_5 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 435.0
PYH1_k127_4103424_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 426.0
PYH1_k127_4103424_7 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 424.0
PYH1_k127_4103424_8 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006918 409.0
PYH1_k127_4103424_9 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 380.0
PYH1_k127_4181888_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1151.0
PYH1_k127_4181888_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 5.477e-257 801.0
PYH1_k127_4181888_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 466.0
PYH1_k127_4181888_3 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 428.0
PYH1_k127_4181888_4 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007945 253.0
PYH1_k127_4181888_5 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000002736 209.0
PYH1_k127_4181888_6 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000003825 136.0
PYH1_k127_4181888_7 Beta-propeller repeat - - - 0.00000000000006329 73.0
PYH1_k127_4270787_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.957e-298 923.0
PYH1_k127_4270787_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.453e-259 804.0
PYH1_k127_4270787_10 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 453.0
PYH1_k127_4270787_11 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 451.0
PYH1_k127_4270787_12 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 426.0
PYH1_k127_4270787_13 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 425.0
PYH1_k127_4270787_14 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 417.0
PYH1_k127_4270787_15 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 401.0
PYH1_k127_4270787_16 Branched-chain amino acid transport system permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 385.0
PYH1_k127_4270787_17 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 380.0
PYH1_k127_4270787_18 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 375.0
PYH1_k127_4270787_19 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 362.0
PYH1_k127_4270787_2 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 8.174e-255 803.0
PYH1_k127_4270787_20 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 359.0
PYH1_k127_4270787_21 V-type ATP synthase, subunit I K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 350.0
PYH1_k127_4270787_22 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 322.0
PYH1_k127_4270787_23 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 321.0
PYH1_k127_4270787_24 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 306.0
PYH1_k127_4270787_25 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 308.0
PYH1_k127_4270787_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 314.0
PYH1_k127_4270787_27 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008476 307.0
PYH1_k127_4270787_28 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 300.0
PYH1_k127_4270787_29 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 297.0
PYH1_k127_4270787_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.437e-245 769.0
PYH1_k127_4270787_30 FHA domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 289.0
PYH1_k127_4270787_31 archaeosine synthase activity K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 286.0
PYH1_k127_4270787_32 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001381 291.0
PYH1_k127_4270787_33 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000101 267.0
PYH1_k127_4270787_34 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003653 263.0
PYH1_k127_4270787_35 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001406 265.0
PYH1_k127_4270787_36 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
PYH1_k127_4270787_37 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007836 240.0
PYH1_k127_4270787_38 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000004855 231.0
PYH1_k127_4270787_39 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000008808 243.0
PYH1_k127_4270787_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 6.95e-210 659.0
PYH1_k127_4270787_40 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000000000000000000005207 231.0
PYH1_k127_4270787_41 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000006552 214.0
PYH1_k127_4270787_42 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000005863 214.0
PYH1_k127_4270787_43 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000001242 192.0
PYH1_k127_4270787_44 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000001353 190.0
PYH1_k127_4270787_45 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000006862 183.0
PYH1_k127_4270787_46 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000008925 188.0
PYH1_k127_4270787_47 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000000000000001654 175.0
PYH1_k127_4270787_48 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000005641 167.0
PYH1_k127_4270787_49 ATP synthase subunit K K02124 - - 0.00000000000000000000000000000000000000000001906 165.0
PYH1_k127_4270787_5 V-type ATPase 116kDa subunit family K02123 - - 6.595e-199 638.0
PYH1_k127_4270787_50 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000002276 168.0
PYH1_k127_4270787_51 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000197 138.0
PYH1_k127_4270787_52 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000001722 123.0
PYH1_k127_4270787_53 Phosphate-starvation-inducible E - - - 0.0000000000000000000000000006838 117.0
PYH1_k127_4270787_54 PFAM GCN5-related N-acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.000000000000000000000000001254 117.0
PYH1_k127_4270787_55 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000145 120.0
PYH1_k127_4270787_56 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000003618 120.0
PYH1_k127_4270787_57 Universal stress protein family - - - 0.00000000000000000000000001185 116.0
PYH1_k127_4270787_58 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000005773 109.0
PYH1_k127_4270787_59 ATP synthase subunit C K02124 - - 0.00000000000000000000007405 99.0
PYH1_k127_4270787_6 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 6.212e-197 623.0
PYH1_k127_4270787_60 ATP synthase subunit C K02124 - - 0.00000000000000000000653 94.0
PYH1_k127_4270787_61 Protein of unknown function (DUF2764) - - - 0.000000000000000000007119 98.0
PYH1_k127_4270787_62 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000005921 90.0
PYH1_k127_4270787_63 metallopeptidase activity - - - 0.000000000000000004379 98.0
PYH1_k127_4270787_64 - - - - 0.000000000000001152 85.0
PYH1_k127_4270787_66 PFAM Protein kinase domain - - - 0.000000000000007394 83.0
PYH1_k127_4270787_67 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.00000000000006406 85.0
PYH1_k127_4270787_69 membrane transporter protein K07090 - - 0.00000000005042 70.0
PYH1_k127_4270787_7 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 556.0
PYH1_k127_4270787_70 S-layer homology domain - - - 0.00000000967 69.0
PYH1_k127_4270787_71 COG1520 FOG WD40-like repeat - - - 0.00000002999 59.0
PYH1_k127_4270787_72 helicase C-terminal domain protein - - - 0.0000002585 61.0
PYH1_k127_4270787_73 membrane transporter protein K07090 - - 0.0000003293 58.0
PYH1_k127_4270787_74 H subunit K02107 - - 0.0000264 51.0
PYH1_k127_4270787_8 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 552.0
PYH1_k127_4270787_9 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 458.0
PYH1_k127_4288736_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.417e-227 710.0
PYH1_k127_4288736_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 2.574e-224 713.0
PYH1_k127_4288736_10 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000005758 203.0
PYH1_k127_4288736_11 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000000002543 176.0
PYH1_k127_4288736_12 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000003406 152.0
PYH1_k127_4288736_13 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000003535 140.0
PYH1_k127_4288736_14 DNA polymerase activity K02319 - 2.7.7.7 0.000000000000000000000000000000000002766 145.0
PYH1_k127_4288736_15 Proline dehydrogenase K00318 GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.000000000000000000000004718 112.0
PYH1_k127_4288736_17 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000007725 64.0
PYH1_k127_4288736_18 - - - - 0.00000000188 63.0
PYH1_k127_4288736_19 - - - - 0.000000005114 58.0
PYH1_k127_4288736_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.023e-194 614.0
PYH1_k127_4288736_20 - - - - 0.000001569 58.0
PYH1_k127_4288736_3 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 544.0
PYH1_k127_4288736_4 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 346.0
PYH1_k127_4288736_5 NAD(P)H dehydrogenase (quinone) activity K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009361 308.0
PYH1_k127_4288736_6 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 296.0
PYH1_k127_4288736_7 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000000000005868 256.0
PYH1_k127_4288736_8 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000008763 235.0
PYH1_k127_4288736_9 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000000000000000000000000000000005601 220.0
PYH1_k127_4686812_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.051e-317 980.0
PYH1_k127_4686812_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 5.5e-300 939.0
PYH1_k127_4686812_10 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 355.0
PYH1_k127_4686812_11 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 338.0
PYH1_k127_4686812_12 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 310.0
PYH1_k127_4686812_13 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000127 254.0
PYH1_k127_4686812_14 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000005434 245.0
PYH1_k127_4686812_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000001246 230.0
PYH1_k127_4686812_16 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000201 212.0
PYH1_k127_4686812_17 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000000001225 186.0
PYH1_k127_4686812_18 protein conserved in archaea K09723 - - 0.00000000000000000000000000000000000000000000000001333 186.0
PYH1_k127_4686812_19 B-block binding subunit of TFIIIC - - - 0.00000000000000000000000000000000000000000000001226 174.0
PYH1_k127_4686812_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 9.27e-247 765.0
PYH1_k127_4686812_20 PFAM Yip1 domain - - - 0.000000000000000000000000000000000008657 143.0
PYH1_k127_4686812_21 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000000002832 135.0
PYH1_k127_4686812_22 - - - - 0.0000000000000000000000000000000001836 134.0
PYH1_k127_4686812_23 TfuA-like protein - - - 0.0000000000000000000000000000000009748 139.0
PYH1_k127_4686812_24 COG0237 Dephospho-CoA kinase - - - 0.00000000000000000000004324 106.0
PYH1_k127_4686812_25 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000001421 101.0
PYH1_k127_4686812_26 - - - - 0.0000000000000000000001919 99.0
PYH1_k127_4686812_27 PFAM Ribosomal protein S27E K02978 - - 0.000000000000000000007235 97.0
PYH1_k127_4686812_28 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000003447 76.0
PYH1_k127_4686812_29 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000001565 58.0
PYH1_k127_4686812_3 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 6.324e-206 644.0
PYH1_k127_4686812_4 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 584.0
PYH1_k127_4686812_5 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 565.0
PYH1_k127_4686812_6 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 519.0
PYH1_k127_4686812_7 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 460.0
PYH1_k127_4686812_8 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 450.0
PYH1_k127_4686812_9 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
PYH1_k127_4702410_0 Belongs to the MCM family K10726 - - 0.0 1077.0
PYH1_k127_4702410_1 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 588.0
PYH1_k127_4702410_10 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000008736 263.0
PYH1_k127_4702410_11 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000003221 236.0
PYH1_k127_4702410_12 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000209 209.0
PYH1_k127_4702410_13 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000000003878 131.0
PYH1_k127_4702410_14 Papain family cysteine protease - - - 0.0000000000000000000000000000006135 138.0
PYH1_k127_4702410_15 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000000009062 120.0
PYH1_k127_4702410_16 CARDB - - - 0.00000002357 66.0
PYH1_k127_4702410_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 507.0
PYH1_k127_4702410_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 461.0
PYH1_k127_4702410_4 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 377.0
PYH1_k127_4702410_5 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 357.0
PYH1_k127_4702410_6 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 338.0
PYH1_k127_4702410_7 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 334.0
PYH1_k127_4702410_8 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 308.0
PYH1_k127_4702410_9 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 301.0
PYH1_k127_499052_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.483e-305 965.0
PYH1_k127_499052_1 Transposase, Mutator family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 308.0
PYH1_k127_499052_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000004291 132.0
PYH1_k127_5177_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1253.0
PYH1_k127_5177_1 PFAM PKD domain containing protein - - - 2.42e-215 710.0
PYH1_k127_5177_2 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 309.0
PYH1_k127_5177_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 291.0
PYH1_k127_5177_4 protein conserved in archaea K09746 - - 0.00000000000000000000000000001068 128.0
PYH1_k127_5236856_0 PFAM ribonuclease II K01147 - 3.1.13.1 2.476e-215 681.0
PYH1_k127_5236856_1 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 528.0
PYH1_k127_5236856_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 402.0
PYH1_k127_5236856_3 COG1520 FOG WD40-like repeat - - - 0.00000000000000000000000000000000000000000000002392 184.0
PYH1_k127_5236856_4 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000003757 149.0
PYH1_k127_5236856_5 - - - - 0.0000000000000000000000002253 116.0
PYH1_k127_5236856_6 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000004112 91.0
PYH1_k127_5236856_7 Protein of unknown function (DUF998) - - - 0.00000000000002613 81.0
PYH1_k127_5236856_8 - - - - 0.000002892 55.0
PYH1_k127_5236856_9 Rubrerythrin - - - 0.00006026 50.0
PYH1_k127_5297470_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006805 594.0
PYH1_k127_5297470_1 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 508.0
PYH1_k127_5297470_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 456.0
PYH1_k127_5297470_3 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000139 203.0
PYH1_k127_5297470_4 Methyltransferase K15429 - 2.1.1.228 0.0000000000000004479 80.0
PYH1_k127_5385331_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1351.0
PYH1_k127_5385331_1 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 5.197e-251 779.0
PYH1_k127_5385331_10 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 455.0
PYH1_k127_5385331_11 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 441.0
PYH1_k127_5385331_12 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 424.0
PYH1_k127_5385331_13 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 419.0
PYH1_k127_5385331_14 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 385.0
PYH1_k127_5385331_15 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 374.0
PYH1_k127_5385331_16 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 371.0
PYH1_k127_5385331_17 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 354.0
PYH1_k127_5385331_18 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 347.0
PYH1_k127_5385331_19 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 344.0
PYH1_k127_5385331_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.553e-250 785.0
PYH1_k127_5385331_20 PFAM GTP-binding protein HSR1-related K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008403 343.0
PYH1_k127_5385331_21 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 345.0
PYH1_k127_5385331_22 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 341.0
PYH1_k127_5385331_23 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 339.0
PYH1_k127_5385331_24 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 317.0
PYH1_k127_5385331_25 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
PYH1_k127_5385331_26 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001041 286.0
PYH1_k127_5385331_27 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001721 274.0
PYH1_k127_5385331_28 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001026 264.0
PYH1_k127_5385331_29 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005659 262.0
PYH1_k127_5385331_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 9.664e-211 660.0
PYH1_k127_5385331_30 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001049 255.0
PYH1_k127_5385331_31 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001558 243.0
PYH1_k127_5385331_32 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000004074 239.0
PYH1_k127_5385331_33 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000000000000000000000000002331 241.0
PYH1_k127_5385331_34 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000005995 227.0
PYH1_k127_5385331_35 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000001303 221.0
PYH1_k127_5385331_36 chromosome segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000000000000000000000000000001314 222.0
PYH1_k127_5385331_37 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000001949 218.0
PYH1_k127_5385331_38 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000003889 204.0
PYH1_k127_5385331_39 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000005487 196.0
PYH1_k127_5385331_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 7.142e-209 664.0
PYH1_k127_5385331_40 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000000062 176.0
PYH1_k127_5385331_41 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000009174 170.0
PYH1_k127_5385331_42 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000003322 180.0
PYH1_k127_5385331_43 - - - - 0.00000000000000000000000000000000000003082 145.0
PYH1_k127_5385331_44 - - - - 0.00000000000000000000000000000000001047 138.0
PYH1_k127_5385331_45 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000002324 134.0
PYH1_k127_5385331_46 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000000002881 130.0
PYH1_k127_5385331_47 - - - - 0.000000000000000000000000003183 112.0
PYH1_k127_5385331_48 - - - - 0.0000000000000000000000000141 110.0
PYH1_k127_5385331_49 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000003684 113.0
PYH1_k127_5385331_5 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 1.561e-195 631.0
PYH1_k127_5385331_50 - - - - 0.00000000000000000000003639 106.0
PYH1_k127_5385331_51 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000007935 99.0
PYH1_k127_5385331_52 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000000008205 98.0
PYH1_k127_5385331_53 - - - - 0.0000001403 58.0
PYH1_k127_5385331_6 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 605.0
PYH1_k127_5385331_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 564.0
PYH1_k127_5385331_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 485.0
PYH1_k127_5385331_9 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 469.0
PYH1_k127_5506108_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 292.0
PYH1_k127_5506108_1 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008754 275.0
PYH1_k127_5506108_2 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002901 241.0
PYH1_k127_5506108_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000000000000000000000000000000001235 220.0
PYH1_k127_5506108_4 - - - - 0.000000000000000000000000000000000006379 139.0
PYH1_k127_5506108_5 Glutaredoxin - - - 0.0000000000000000000000000000000002621 136.0
PYH1_k127_5551_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.396e-291 901.0
PYH1_k127_5551_1 PFAM Thiolase K00626 - 2.3.1.9 1.829e-212 664.0
PYH1_k127_5551_10 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 364.0
PYH1_k127_5551_11 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 317.0
PYH1_k127_5551_12 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 317.0
PYH1_k127_5551_13 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 310.0
PYH1_k127_5551_14 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 291.0
PYH1_k127_5551_15 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 287.0
PYH1_k127_5551_16 Helix-turn-helix domain protein K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004943 253.0
PYH1_k127_5551_17 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000005692 254.0
PYH1_k127_5551_18 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000003333 221.0
PYH1_k127_5551_19 Prokaryotic homologs of the JAB domain - - - 0.000000000000000000000000000000000000000000000000000006191 191.0
PYH1_k127_5551_2 PFAM dihydropteroate synthase, DHPS - - - 1.563e-196 623.0
PYH1_k127_5551_20 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000000000000000000000000000000002724 181.0
PYH1_k127_5551_21 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000001461 166.0
PYH1_k127_5551_22 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000003895 141.0
PYH1_k127_5551_23 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000014 141.0
PYH1_k127_5551_24 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000000000000000000000000000000123 135.0
PYH1_k127_5551_25 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000004552 126.0
PYH1_k127_5551_26 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000009534 104.0
PYH1_k127_5551_27 Ferredoxin K05337 - - 0.00000000000000003821 83.0
PYH1_k127_5551_3 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 599.0
PYH1_k127_5551_4 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009481 596.0
PYH1_k127_5551_5 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 565.0
PYH1_k127_5551_6 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 544.0
PYH1_k127_5551_7 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 473.0
PYH1_k127_5551_8 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 469.0
PYH1_k127_5551_9 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 411.0
PYH1_k127_5575701_0 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 539.0
PYH1_k127_5575701_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 514.0
PYH1_k127_5575701_2 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 443.0
PYH1_k127_5575701_3 Alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 364.0
PYH1_k127_5575701_4 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001231 235.0
PYH1_k127_5575701_5 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000402 101.0
PYH1_k127_5575701_7 Domain of unknown function (DUF3821) - - - 0.000002219 50.0
PYH1_k127_5676477_0 Belongs to the glutamate synthase family - - - 4.512e-273 846.0
PYH1_k127_5676477_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 9.744e-236 735.0
PYH1_k127_5676477_10 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 428.0
PYH1_k127_5676477_11 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 422.0
PYH1_k127_5676477_12 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008282 399.0
PYH1_k127_5676477_13 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 391.0
PYH1_k127_5676477_14 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 381.0
PYH1_k127_5676477_15 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 402.0
PYH1_k127_5676477_16 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 370.0
PYH1_k127_5676477_17 PFAM glutamate synthase alpha subunit domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 334.0
PYH1_k127_5676477_18 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 330.0
PYH1_k127_5676477_19 PFAM amino acid-binding ACT domain protein K06862 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 329.0
PYH1_k127_5676477_2 Ferrous iron transport B domain protein K04759 - - 8.897e-227 718.0
PYH1_k127_5676477_20 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 307.0
PYH1_k127_5676477_21 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000004972 265.0
PYH1_k127_5676477_22 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001116 273.0
PYH1_k127_5676477_23 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000004071 238.0
PYH1_k127_5676477_24 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000000000000000000000000107 242.0
PYH1_k127_5676477_25 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000593 208.0
PYH1_k127_5676477_26 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000007372 201.0
PYH1_k127_5676477_27 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000004559 201.0
PYH1_k127_5676477_28 LysM domain - - - 0.000000000000000000000000000000000000000000000000267 192.0
PYH1_k127_5676477_29 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000006238 179.0
PYH1_k127_5676477_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.003e-211 662.0
PYH1_k127_5676477_30 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000002958 181.0
PYH1_k127_5676477_31 Acetylglutamate kinase - - - 0.000000000000000000000000000000000000000000004741 179.0
PYH1_k127_5676477_32 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000005093 166.0
PYH1_k127_5676477_33 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000004846 156.0
PYH1_k127_5676477_34 iron dependent repressor K03709,K04758 - - 0.00000000000000000000000000000000000000002004 160.0
PYH1_k127_5676477_35 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000000001363 148.0
PYH1_k127_5676477_36 - - - - 0.0000000000000000000000000000000000002507 146.0
PYH1_k127_5676477_37 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000000000000005648 136.0
PYH1_k127_5676477_38 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000004044 115.0
PYH1_k127_5676477_39 - - - - 0.00000000000000000000005108 105.0
PYH1_k127_5676477_4 Helix-hairpin-helix domain K02347 - - 5.658e-199 634.0
PYH1_k127_5676477_40 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000005781 93.0
PYH1_k127_5676477_41 - K01448 - 3.5.1.28 0.0000000000000002306 82.0
PYH1_k127_5676477_42 PFAM PKD domain containing protein - - - 0.0000000000001723 80.0
PYH1_k127_5676477_44 Belongs to the peptidase S8 family - - - 0.00000000008448 76.0
PYH1_k127_5676477_45 TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0007745 42.0
PYH1_k127_5676477_5 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 594.0
PYH1_k127_5676477_6 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 596.0
PYH1_k127_5676477_7 PFAM glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 539.0
PYH1_k127_5676477_8 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 506.0
PYH1_k127_5676477_9 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 443.0
PYH1_k127_5708872_0 Protein of unknown function (DUF460) K09150 - - 2.724e-255 802.0
PYH1_k127_5708872_1 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 380.0
PYH1_k127_5708872_2 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 359.0
PYH1_k127_5708872_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000009965 229.0
PYH1_k127_5708872_4 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000001258 156.0
PYH1_k127_5851990_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 407.0
PYH1_k127_5851990_1 PFAM major facilitator superfamily MFS_1 K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 387.0
PYH1_k127_5851990_2 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 341.0
PYH1_k127_5851990_3 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0007445 47.0
PYH1_k127_5980566_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1079.0
PYH1_k127_5980566_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.619e-237 757.0
PYH1_k127_5980566_10 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000003493 224.0
PYH1_k127_5980566_11 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000005788 173.0
PYH1_k127_5980566_12 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000006778 167.0
PYH1_k127_5980566_13 peptide deformylase activity K01462 - 3.5.1.88 0.00000000000000000000000000009984 123.0
PYH1_k127_5980566_14 - - - - 0.000000000000000000000000000106 126.0
PYH1_k127_5980566_15 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000000000003094 108.0
PYH1_k127_5980566_16 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000000000000003827 91.0
PYH1_k127_5980566_17 Protein of unknown function (DUF2769) - - - 0.000000000000000001545 94.0
PYH1_k127_5980566_18 - - - - 0.00000000000001863 74.0
PYH1_k127_5980566_19 PFAM YHS domain - - - 0.00000000001157 72.0
PYH1_k127_5980566_2 Belongs to the glutamate synthase family - - - 2.418e-219 691.0
PYH1_k127_5980566_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 449.0
PYH1_k127_5980566_4 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005835 421.0
PYH1_k127_5980566_5 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 384.0
PYH1_k127_5980566_6 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 350.0
PYH1_k127_5980566_7 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 346.0
PYH1_k127_5980566_8 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 332.0
PYH1_k127_5980566_9 PFAM Ferritin, Dps family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 317.0
PYH1_k127_5988370_0 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002742 239.0
PYH1_k127_5988370_1 - - - - 0.0000000000000000000000000000000000000000000000000001073 200.0
PYH1_k127_5988370_3 - - - - 0.0000000000000000000006439 104.0
PYH1_k127_6001374_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1853.0
PYH1_k127_6001374_1 Radical SAM ThiC family K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 518.0
PYH1_k127_6001374_2 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006254 269.0
PYH1_k127_6001374_3 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002592 252.0
PYH1_k127_6001374_4 Protein of unknown function (DUF432) K09149 - - 0.0000000000000000000000000000000000000000000000000000000000005707 218.0
PYH1_k127_6001374_5 - - - - 0.000000000000000000000000000000000002271 143.0
PYH1_k127_6001374_6 PBS lyase HEAT-like repeat - - - 0.000000000417 65.0
PYH1_k127_6003558_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009228 576.0
PYH1_k127_6003558_1 PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 546.0
PYH1_k127_6003558_2 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 474.0
PYH1_k127_6003558_3 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 459.0
PYH1_k127_6003558_4 PFAM glutamate--cysteine ligase, GCS2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 396.0
PYH1_k127_6003558_5 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000008355 115.0
PYH1_k127_6097145_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 466.0
PYH1_k127_6097145_1 methanogenesis marker protein 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 418.0
PYH1_k127_6097145_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 312.0
PYH1_k127_6097145_3 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004296 232.0
PYH1_k127_6097145_4 Molybdopterin oxidoreductase K00201 - 1.2.7.12 0.0000000000000000000001548 97.0
PYH1_k127_6097145_5 transcriptional regulators K03724 - - 0.0000000000000000634 82.0
PYH1_k127_6097145_6 Rubredoxin - - - 0.000000000000004102 78.0
PYH1_k127_6097145_7 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.00000006473 55.0
PYH1_k127_6134606_0 Sulfatase K01130 - 3.1.6.1 3.242e-311 964.0
PYH1_k127_6134606_1 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 556.0
PYH1_k127_6134606_10 - - - - 0.00000000003396 70.0
PYH1_k127_6134606_11 Transposase DDE domain - - - 0.0000000438 57.0
PYH1_k127_6134606_12 Short repeat of unknown function (DUF308) - - - 0.0002032 51.0
PYH1_k127_6134606_2 Sulfate permease family K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 464.0
PYH1_k127_6134606_3 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 413.0
PYH1_k127_6134606_4 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002136 267.0
PYH1_k127_6134606_5 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
PYH1_k127_6134606_6 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000000000004744 211.0
PYH1_k127_6134606_7 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000008873 201.0
PYH1_k127_6134606_8 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000002853 195.0
PYH1_k127_6134606_9 Flavodoxin - - - 0.00000000000000000000000000000003709 134.0
PYH1_k127_6139251_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1233.0
PYH1_k127_6139251_1 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 2.808e-298 928.0
PYH1_k127_6139251_10 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 8.482e-205 646.0
PYH1_k127_6139251_11 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 1.412e-195 620.0
PYH1_k127_6139251_12 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 612.0
PYH1_k127_6139251_13 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 584.0
PYH1_k127_6139251_14 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 589.0
PYH1_k127_6139251_15 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 582.0
PYH1_k127_6139251_16 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 579.0
PYH1_k127_6139251_17 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 568.0
PYH1_k127_6139251_18 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 567.0
PYH1_k127_6139251_19 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 547.0
PYH1_k127_6139251_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.585e-284 890.0
PYH1_k127_6139251_20 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 544.0
PYH1_k127_6139251_21 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 529.0
PYH1_k127_6139251_22 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 527.0
PYH1_k127_6139251_23 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 520.0
PYH1_k127_6139251_24 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 493.0
PYH1_k127_6139251_25 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 478.0
PYH1_k127_6139251_26 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 478.0
PYH1_k127_6139251_27 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 484.0
PYH1_k127_6139251_28 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 463.0
PYH1_k127_6139251_29 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 465.0
PYH1_k127_6139251_3 PFAM ABC transporter K00400 - - 2.718e-281 871.0
PYH1_k127_6139251_30 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 476.0
PYH1_k127_6139251_31 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 416.0
PYH1_k127_6139251_32 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 406.0
PYH1_k127_6139251_33 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 410.0
PYH1_k127_6139251_34 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008708 399.0
PYH1_k127_6139251_35 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 379.0
PYH1_k127_6139251_36 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 373.0
PYH1_k127_6139251_37 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 374.0
PYH1_k127_6139251_38 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 366.0
PYH1_k127_6139251_39 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 361.0
PYH1_k127_6139251_4 SMART Elongator protein 3 MiaB NifB - - - 4.839e-261 816.0
PYH1_k127_6139251_40 nucleoside 2-deoxyribosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 342.0
PYH1_k127_6139251_41 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 340.0
PYH1_k127_6139251_42 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 334.0
PYH1_k127_6139251_43 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
PYH1_k127_6139251_44 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 331.0
PYH1_k127_6139251_45 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 325.0
PYH1_k127_6139251_46 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 316.0
PYH1_k127_6139251_47 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 310.0
PYH1_k127_6139251_48 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 310.0
PYH1_k127_6139251_49 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 282.0
PYH1_k127_6139251_5 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.102e-254 788.0
PYH1_k127_6139251_50 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003133 280.0
PYH1_k127_6139251_51 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
PYH1_k127_6139251_52 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000362 269.0
PYH1_k127_6139251_53 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004507 269.0
PYH1_k127_6139251_54 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001666 271.0
PYH1_k127_6139251_55 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000002131 271.0
PYH1_k127_6139251_56 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002634 267.0
PYH1_k127_6139251_57 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000001605 264.0
PYH1_k127_6139251_58 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
PYH1_k127_6139251_59 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009094 248.0
PYH1_k127_6139251_6 Involved in regulation of DNA replication K10725 - - 9.512e-219 685.0
PYH1_k127_6139251_60 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000007568 238.0
PYH1_k127_6139251_61 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000001594 238.0
PYH1_k127_6139251_62 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001532 236.0
PYH1_k127_6139251_63 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003735 233.0
PYH1_k127_6139251_64 - - - - 0.00000000000000000000000000000000000000000000000000000000000001205 227.0
PYH1_k127_6139251_65 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000002456 227.0
PYH1_k127_6139251_66 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000003464 217.0
PYH1_k127_6139251_67 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000000000000006518 213.0
PYH1_k127_6139251_68 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000001401 210.0
PYH1_k127_6139251_69 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000007345 202.0
PYH1_k127_6139251_7 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.22e-216 677.0
PYH1_k127_6139251_70 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000005076 204.0
PYH1_k127_6139251_71 PFAM response regulator receiveR - - - 0.000000000000000000000000000000000000000000000000007439 185.0
PYH1_k127_6139251_72 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000005411 186.0
PYH1_k127_6139251_73 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000001119 179.0
PYH1_k127_6139251_74 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000002924 184.0
PYH1_k127_6139251_75 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000000001518 172.0
PYH1_k127_6139251_76 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000001456 176.0
PYH1_k127_6139251_77 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001464 171.0
PYH1_k127_6139251_78 Yip1 domain - - - 0.000000000000000000000000000000000000000000043 169.0
PYH1_k127_6139251_79 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000006108 164.0
PYH1_k127_6139251_8 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 9.998e-212 666.0
PYH1_k127_6139251_80 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000000000000000000000000000001523 159.0
PYH1_k127_6139251_81 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000004662 148.0
PYH1_k127_6139251_82 - - - - 0.000000000000000000000000000000000005066 143.0
PYH1_k127_6139251_83 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000005463 141.0
PYH1_k127_6139251_84 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000001021 146.0
PYH1_k127_6139251_85 Domain of unknown function (DUF1805) - - - 0.000000000000000000000000000000131 126.0
PYH1_k127_6139251_86 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000001648 128.0
PYH1_k127_6139251_87 Protein of unknown function DUF86 K07075 - - 0.0000000000000000000001318 106.0
PYH1_k127_6139251_88 Trm112p-like protein - - - 0.000000000000000000505 87.0
PYH1_k127_6139251_89 Domain of unknown function (DUF3821) - - - 0.000000000000687 76.0
PYH1_k127_6139251_9 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 8.027e-206 647.0
PYH1_k127_6139251_90 SMART PAS domain containing protein - - - 0.00000000001083 76.0
PYH1_k127_6139251_91 - - - - 0.000000009875 63.0
PYH1_k127_6336274_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1219.0
PYH1_k127_6336274_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1182.0
PYH1_k127_6336274_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 426.0
PYH1_k127_6336274_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 349.0
PYH1_k127_6336274_4 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 322.0
PYH1_k127_6336274_5 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 287.0
PYH1_k127_6336274_6 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003183 250.0
PYH1_k127_6336274_7 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000001136 103.0
PYH1_k127_6528237_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 290.0
PYH1_k127_6528237_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000101 281.0
PYH1_k127_6528237_2 O-methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005082 270.0
PYH1_k127_6528237_3 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008031 267.0
PYH1_k127_6528237_4 - - - - 0.000000000000000000000000000000000000000000000000000000002633 209.0
PYH1_k127_6528237_5 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000000007337 159.0
PYH1_k127_6528237_6 Transcriptional regulator K07729 - - 0.0000000000000000000000006156 107.0
PYH1_k127_6528237_7 DNA glycosylase - - - 0.00000000000008181 74.0
PYH1_k127_6528237_8 - - - - 0.000000004009 65.0
PYH1_k127_6755639_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 6.351e-234 734.0
PYH1_k127_6755639_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 456.0
PYH1_k127_6755639_2 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006566 261.0
PYH1_k127_6755639_3 metal-binding protein - - - 0.0000000000000000000000000001148 117.0
PYH1_k127_6823820_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 404.0
PYH1_k127_6823820_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001232 278.0
PYH1_k127_6823820_2 - - - - 0.000000000000000000000000000000000000000000000000001085 186.0
PYH1_k127_6823820_3 PFAM aldo keto reductase K07079 - - 0.00000000000000003556 81.0
PYH1_k127_6823820_4 TIR domain - - - 0.000000000000001362 82.0
PYH1_k127_6823820_5 - - - - 0.0001259 47.0
PYH1_k127_6849870_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1019.0
PYH1_k127_6849870_1 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.113e-212 665.0
PYH1_k127_6849870_10 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000009974 214.0
PYH1_k127_6849870_11 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000443 196.0
PYH1_k127_6849870_12 NLP P60 protein - - - 0.0000000000000000000000000000000000006837 147.0
PYH1_k127_6849870_13 Matrixin - - - 0.000000000000000000000000000000000001602 147.0
PYH1_k127_6849870_14 - - - - 0.000000000000000000000000000000000406 134.0
PYH1_k127_6849870_15 - - - - 0.00000000000000000000000000000009366 126.0
PYH1_k127_6849870_16 Mur ligase K01932 - - 0.0000000000000000000000000000006059 136.0
PYH1_k127_6849870_17 - - - - 0.0000000000001855 72.0
PYH1_k127_6849870_18 Capsule biosynthesis CapC - - - 0.00000000005485 70.0
PYH1_k127_6849870_19 CHY zinc finger K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000001357 70.0
PYH1_k127_6849870_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 559.0
PYH1_k127_6849870_20 PFAM aminotransferase class V - - - 0.000000004202 59.0
PYH1_k127_6849870_22 - - - - 0.0000585 47.0
PYH1_k127_6849870_3 PFAM Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 561.0
PYH1_k127_6849870_4 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 429.0
PYH1_k127_6849870_5 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 366.0
PYH1_k127_6849870_6 PFAM DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 362.0
PYH1_k127_6849870_7 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001353 277.0
PYH1_k127_6849870_8 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005352 262.0
PYH1_k127_6849870_9 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000002042 239.0
PYH1_k127_6948076_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.723e-230 720.0
PYH1_k127_6948076_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 528.0
PYH1_k127_6948076_2 Membrane protein of unknown function DUF63 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 364.0
PYH1_k127_6948076_3 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000000002884 214.0
PYH1_k127_6948076_4 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000000000000000002536 179.0
PYH1_k127_6948076_5 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000002101 93.0
PYH1_k127_6948076_6 - - - - 0.0000000000415 64.0
PYH1_k127_7115622_0 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 395.0
PYH1_k127_7115622_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 287.0
PYH1_k127_7115622_2 - - - - 0.00000004642 60.0
PYH1_k127_7391178_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 3.27e-245 765.0
PYH1_k127_7391178_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009198 417.0
PYH1_k127_7391178_10 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000002654 89.0
PYH1_k127_7391178_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000003878 89.0
PYH1_k127_7391178_12 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000001367 80.0
PYH1_k127_7391178_2 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 355.0
PYH1_k127_7391178_3 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 307.0
PYH1_k127_7391178_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000006544 213.0
PYH1_k127_7391178_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000000001304 196.0
PYH1_k127_7391178_6 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000007945 155.0
PYH1_k127_7391178_7 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000000000001225 152.0
PYH1_k127_7391178_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000000000001882 112.0
PYH1_k127_7391178_9 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000000000001501 97.0
PYH1_k127_7418937_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1021.0
PYH1_k127_7418937_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.243e-278 859.0
PYH1_k127_7418937_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 595.0
PYH1_k127_7418937_3 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005192 438.0
PYH1_k127_7418937_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 331.0
PYH1_k127_7418937_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000001086 182.0
PYH1_k127_7418937_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000001282 97.0
PYH1_k127_7418937_7 - - - - 0.000000000000001503 83.0
PYH1_k127_7424175_0 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 482.0
PYH1_k127_7424175_1 Beta propeller domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 310.0
PYH1_k127_7424175_2 Flavodoxin - GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000001749 206.0
PYH1_k127_7424175_3 PFAM Yip1 domain - - - 0.0000000000000000000000005294 113.0
PYH1_k127_7556054_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0 1144.0
PYH1_k127_7556054_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 2.041e-198 630.0
PYH1_k127_7556054_10 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
PYH1_k127_7556054_11 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000002085 190.0
PYH1_k127_7556054_12 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000000000003656 184.0
PYH1_k127_7556054_13 - - - - 0.00000000000000000000000000000003041 136.0
PYH1_k127_7556054_14 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000001059 122.0
PYH1_k127_7556054_15 - - - - 0.0000000000000000000000000003268 121.0
PYH1_k127_7556054_16 TIR domain - - - 0.0000000000000000000000007191 111.0
PYH1_k127_7556054_17 PFAM peptidase U32 K08303 - - 0.00000000000000000000299 96.0
PYH1_k127_7556054_18 - - - - 0.00000000000000002323 91.0
PYH1_k127_7556054_19 - - - - 0.0000000000000001126 83.0
PYH1_k127_7556054_2 Bacterial protein of unknown function (DUF853) K06915 - - 6.102e-196 622.0
PYH1_k127_7556054_20 Domain of unknown function (DUF4405) - - - 0.000000000000007886 81.0
PYH1_k127_7556054_21 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0000000000009276 80.0
PYH1_k127_7556054_23 PFAM Uncharacterised conserved protein UCP006577 - - - 0.000008218 53.0
PYH1_k127_7556054_24 Flavodoxin - - - 0.00009953 48.0
PYH1_k127_7556054_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 404.0
PYH1_k127_7556054_4 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 309.0
PYH1_k127_7556054_5 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 297.0
PYH1_k127_7556054_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
PYH1_k127_7556054_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002406 279.0
PYH1_k127_7556054_8 Putative NAD(P)-binding K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001737 274.0
PYH1_k127_7556054_9 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000002147 229.0
PYH1_k127_7772192_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 5.349e-263 815.0
PYH1_k127_7772192_1 Flavodoxin - - - 0.000000000000000000000000000000000000000000000000000003086 194.0
PYH1_k127_7772192_2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000006382 171.0
PYH1_k127_7950689_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 3.367e-255 802.0
PYH1_k127_7950689_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 3.594e-250 780.0
PYH1_k127_7950689_10 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 338.0
PYH1_k127_7950689_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 306.0
PYH1_k127_7950689_12 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 300.0
PYH1_k127_7950689_14 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
PYH1_k127_7950689_15 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000000000003228 234.0
PYH1_k127_7950689_16 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000004408 222.0
PYH1_k127_7950689_17 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000002631 221.0
PYH1_k127_7950689_18 - - - - 0.0000000000000000000000000000000000000000000000000000007167 197.0
PYH1_k127_7950689_19 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000000001027 194.0
PYH1_k127_7950689_2 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 2.699e-224 700.0
PYH1_k127_7950689_20 Nitroreductase - - - 0.000000000000000000000000000000000000000000000006914 185.0
PYH1_k127_7950689_21 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000006199 173.0
PYH1_k127_7950689_22 - - - - 0.0000000000000000000000000000000000000003116 158.0
PYH1_k127_7950689_23 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000000000000000000005987 141.0
PYH1_k127_7950689_24 PFAM helix-turn-helix domain protein K07729 - - 0.0000000000000000000000000001374 115.0
PYH1_k127_7950689_25 membrane K09167 - - 0.0000000000000000000004754 101.0
PYH1_k127_7950689_26 PFAM Uncharacterised protein family UPF0066 - - - 0.00000000000000000007464 92.0
PYH1_k127_7950689_27 Belongs to the UPF0248 family K09715 - - 0.0000000000000000003791 90.0
PYH1_k127_7950689_28 - - - - 0.0000000000000004892 80.0
PYH1_k127_7950689_29 PQ loop repeat K15383 - - 0.00000004942 59.0
PYH1_k127_7950689_3 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 594.0
PYH1_k127_7950689_30 amino acid-binding ACT domain protein - - - 0.00000934 48.0
PYH1_k127_7950689_31 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.0004335 46.0
PYH1_k127_7950689_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 557.0
PYH1_k127_7950689_5 Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 475.0
PYH1_k127_7950689_6 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 420.0
PYH1_k127_7950689_7 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 414.0
PYH1_k127_7950689_8 permease K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 395.0
PYH1_k127_7950689_9 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 387.0
PYH1_k127_7957070_0 SMART zinc finger, CDGSH-type domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002123 278.0
PYH1_k127_7957070_1 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001325 231.0
PYH1_k127_7957070_2 MaoC like domain - - - 0.000000000000000000000000000000000000000000000002889 177.0
PYH1_k127_7957070_3 alpha/beta hydrolase fold K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000004745 186.0
PYH1_k127_7957070_4 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000031 111.0
PYH1_k127_7957070_5 DNA-binding transcription factor activity K03892 - - 0.0000000000000000000001355 104.0
PYH1_k127_7957070_6 Rieske [2Fe-2S] domain - - - 0.0000000000000000002646 91.0
PYH1_k127_7957070_7 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000006323 73.0
PYH1_k127_7957070_8 Transcription elongation factor K03145 GO:0000003,GO:0001101,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0008150,GO:0009719,GO:0009725,GO:0009739,GO:0009791,GO:0009845,GO:0009889,GO:0009909,GO:0009910,GO:0010033,GO:0010154,GO:0010162,GO:0010431,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0021700,GO:0022414,GO:0022611,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032504,GO:0032784,GO:0033993,GO:0034243,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048316,GO:0048519,GO:0048580,GO:0048581,GO:0048608,GO:0048609,GO:0048731,GO:0048831,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051171,GO:0051239,GO:0051241,GO:0051252,GO:0060255,GO:0061458,GO:0065007,GO:0071695,GO:0080090,GO:0090351,GO:1901700,GO:1903506,GO:2000026,GO:2000112,GO:2000241,GO:2000242,GO:2001141 - 0.0002586 47.0
PYH1_k127_8343804_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 4.801e-197 616.0
PYH1_k127_8343804_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 588.0
PYH1_k127_8343804_10 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 297.0
PYH1_k127_8343804_11 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 298.0
PYH1_k127_8343804_12 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000001063 246.0
PYH1_k127_8343804_13 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000009469 219.0
PYH1_k127_8343804_14 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000004547 216.0
PYH1_k127_8343804_15 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000000000000000000000000000000000000006403 206.0
PYH1_k127_8343804_16 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000000000000000000005302 170.0
PYH1_k127_8343804_17 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000000000000000005914 166.0
PYH1_k127_8343804_18 - - - - 0.00000000000000000000000000000000007694 134.0
PYH1_k127_8343804_19 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000001108 103.0
PYH1_k127_8343804_2 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 561.0
PYH1_k127_8343804_20 PFAM TPR repeat-containing protein - - - 0.0000000000000002518 84.0
PYH1_k127_8343804_21 PFAM TPR repeat-containing protein - - - 0.0000000000000005081 83.0
PYH1_k127_8343804_22 - - - - 0.000000000000000739 78.0
PYH1_k127_8343804_3 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 542.0
PYH1_k127_8343804_4 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 533.0
PYH1_k127_8343804_5 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 500.0
PYH1_k127_8343804_6 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 484.0
PYH1_k127_8343804_7 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 395.0
PYH1_k127_8343804_8 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 372.0
PYH1_k127_8343804_9 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 360.0
PYH1_k127_92016_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 584.0
PYH1_k127_92016_1 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007076 353.0
PYH1_k127_92016_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 311.0
PYH1_k127_92016_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003027 284.0
PYH1_k127_92016_4 - - - - 0.00000000000000000000000000000000000000000000000000004232 202.0
PYH1_k127_922273_0 PFAM Radical SAM domain protein K06937 - - 2.077e-244 762.0
PYH1_k127_922273_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 609.0
PYH1_k127_922273_10 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000006707 152.0
PYH1_k127_922273_11 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000007972 98.0
PYH1_k127_922273_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 554.0
PYH1_k127_922273_3 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 437.0
PYH1_k127_922273_4 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 422.0
PYH1_k127_922273_5 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 360.0
PYH1_k127_922273_6 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000003055 245.0
PYH1_k127_922273_7 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000000000002255 212.0
PYH1_k127_922273_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000004379 188.0
PYH1_k127_922273_9 Small multi-drug export protein - - - 0.00000000000000000000000000000000000000000001051 173.0
PYH1_k127_954808_0 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 571.0
PYH1_k127_954808_1 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 462.0
PYH1_k127_954808_10 DEAD DEAH box helicase K06877 - - 0.000000000000000000000000000000000000000000000000003071 187.0
PYH1_k127_954808_2 MviN-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 455.0
PYH1_k127_954808_3 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 424.0
PYH1_k127_954808_4 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 390.0
PYH1_k127_954808_5 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 299.0
PYH1_k127_954808_6 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 295.0
PYH1_k127_954808_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002977 281.0
PYH1_k127_954808_8 PFAM cyclase family protein K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000003195 231.0
PYH1_k127_954808_9 - - - - 0.000000000000000000000000000000000000000000000000000001834 197.0