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Overview

ID MAG03187
Name PYH2_bin.31
Sample SMP0074
Taxonomy
Kingdom Archaea
Phylum Thermoplasmatota
Class Thermoplasmata
Order JAUWGG01
Family
Genus
Species
Assembly information
Completeness (%) 83.9
Contamination (%) 2.16
GC content (%) 60.0
N50 (bp) 9,572
Genome size (bp) 1,715,961

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1496

Gene name Description KEGG GOs EC E-value Score Sequence
PYH2_k127_110566_0 PFAM Multicopper oxidase - - - 6.243e-201 644.0
PYH2_k127_110566_1 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000002705 161.0
PYH2_k127_110566_2 Transcriptional regulator, AbiEi antitoxin - - - 0.0000000000000000000000000004312 121.0
PYH2_k127_1111988_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 4.521e-198 625.0
PYH2_k127_1111988_1 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000003001 174.0
PYH2_k127_1111988_2 peptidyl-tyrosine sulfation - - - 0.0000004006 56.0
PYH2_k127_119408_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 308.0
PYH2_k127_119408_1 Proton-conducting membrane transporter K00343,K22169 - 1.5.98.3,1.6.5.3 0.000000000000000000000000000000009083 132.0
PYH2_k127_1256_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 441.0
PYH2_k127_1256_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 360.0
PYH2_k127_1256_2 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001284 249.0
PYH2_k127_1256_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000002406 136.0
PYH2_k127_1275427_0 Protein conserved in bacteria K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002904 265.0
PYH2_k127_1275427_1 COG0517 FOG CBS domain - - - 0.000000000008528 77.0
PYH2_k127_1410685_0 UbiA prenyltransferase family K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000007541 242.0
PYH2_k127_1410685_1 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000001066 219.0
PYH2_k127_1410685_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.000000000000000000000000000000000000000000000106 172.0
PYH2_k127_1410685_3 SMART Transcription regulator, AsnC-type - - - 0.0000000000000000000000000000000000003117 147.0
PYH2_k127_1410685_4 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000001338 145.0
PYH2_k127_1410685_5 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.0000000000000000003225 102.0
PYH2_k127_1410685_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.00000000156 69.0
PYH2_k127_1414173_0 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.0000000000000000000000000000000000000000000000000000000000000000001331 234.0
PYH2_k127_1414173_1 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.00000000000000000000000000000000000000000000001843 177.0
PYH2_k127_1414173_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000001479 98.0
PYH2_k127_1486966_0 Required for chromosome condensation and partitioning K03529 - - 3.159e-226 744.0
PYH2_k127_1486966_1 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 1.832e-225 712.0
PYH2_k127_1486966_10 Tetratricopeptide TPR_2 repeat protein - - - 0.0000003019 65.0
PYH2_k127_1486966_11 RecA-superfamily ATPases implicated in signal transduction K08482 - - 0.0008685 54.0
PYH2_k127_1486966_2 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
PYH2_k127_1486966_3 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000009344 242.0
PYH2_k127_1486966_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000008178 200.0
PYH2_k127_1486966_5 chromosome segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000000002312 179.0
PYH2_k127_1486966_6 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000009824 170.0
PYH2_k127_1486966_7 GvpD gas vesicle protein - - - 0.000000000000000000000000000000000000000009321 164.0
PYH2_k127_1486966_8 TIGRFAM segregation and condensation protein B K06024 - - 0.00000000000000000000000000000003836 134.0
PYH2_k127_1486966_9 - - - - 0.00000000000000001217 84.0
PYH2_k127_1594632_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 400.0
PYH2_k127_1594632_1 peptidyl-prolyl cis-trans isomerase K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000001207 225.0
PYH2_k127_1594632_2 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000001855 173.0
PYH2_k127_1594632_3 Nitrous oxide-stimulated promoter - - - 0.000000000000000000000000000000000296 134.0
PYH2_k127_1641071_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.509e-290 910.0
PYH2_k127_1641071_1 Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2.606e-268 857.0
PYH2_k127_1641071_10 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000008688 218.0
PYH2_k127_1641071_11 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000009793 203.0
PYH2_k127_1641071_12 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000000000000001418 200.0
PYH2_k127_1641071_13 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000242 196.0
PYH2_k127_1641071_14 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.0000000000000000000000000000000000000000000000000000468 203.0
PYH2_k127_1641071_15 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000001328 178.0
PYH2_k127_1641071_16 DNA ligase D, 3-phosphoesterase domain - - - 0.000000000000000000000000000000000000002267 149.0
PYH2_k127_1641071_17 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000003262 119.0
PYH2_k127_1641071_18 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.0000000000000000000000001287 110.0
PYH2_k127_1641071_19 hydrolase K01560 - 3.8.1.2 0.00000000000000000002073 101.0
PYH2_k127_1641071_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 561.0
PYH2_k127_1641071_20 PFAM Nickel cobalt transporter, high-affinity - - - 0.0000000000000000001249 101.0
PYH2_k127_1641071_21 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000001174 93.0
PYH2_k127_1641071_22 Protein of unknown function (DUF3198) - - - 0.00000002801 60.0
PYH2_k127_1641071_3 ferredoxin oxidoreductase, alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006481 471.0
PYH2_k127_1641071_4 Dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 370.0
PYH2_k127_1641071_5 PFAM Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 355.0
PYH2_k127_1641071_6 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 350.0
PYH2_k127_1641071_7 PFAM histone deacetylase superfamily K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 319.0
PYH2_k127_1641071_8 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000002302 223.0
PYH2_k127_1641071_9 PFAM Appr-1-p processing domain protein - - - 0.0000000000000000000000000000000000000000000000000000000002437 208.0
PYH2_k127_1662286_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.098e-236 743.0
PYH2_k127_1662286_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 402.0
PYH2_k127_1662286_2 phosphoenolpyruvate carboxykinase (GTP) activity K01596,K01610 - 4.1.1.32,4.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000002321 274.0
PYH2_k127_1662286_3 TIGRFAM Oxaloacetate decarboxylase, alpha subunit K01960 - 6.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000005168 250.0
PYH2_k127_1662286_4 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000001648 183.0
PYH2_k127_1662286_5 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000008112 164.0
PYH2_k127_1662286_6 TIGRFAM small GTP-binding protein domain - - - 0.000000000000000000000004256 113.0
PYH2_k127_1662286_7 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000778 46.0
PYH2_k127_1664531_0 ABC-type Fe3 transport system permease component K02053,K02054,K02063 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 443.0
PYH2_k127_1664531_1 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 317.0
PYH2_k127_1664531_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002381 269.0
PYH2_k127_1664531_3 Subtilase family K17734 - - 0.000000000000000000000000000000000000000000000000000000001814 227.0
PYH2_k127_1664531_4 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000009535 196.0
PYH2_k127_1664531_5 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000001279 184.0
PYH2_k127_1664531_6 PFAM ABC transporter K02010,K10111 - 3.6.3.30 0.00000000000004946 73.0
PYH2_k127_1664531_7 Lipocalin-like domain - - - 0.0000000000001352 83.0
PYH2_k127_1673857_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 438.0
PYH2_k127_1673857_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 346.0
PYH2_k127_1673857_10 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000002899 102.0
PYH2_k127_1673857_11 - - - - 0.000000000000000002917 86.0
PYH2_k127_1673857_2 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 317.0
PYH2_k127_1673857_3 UbiA prenyltransferase family K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 298.0
PYH2_k127_1673857_4 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007519 275.0
PYH2_k127_1673857_5 Polyprenyl synthetase K02523,K13787 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000009184 222.0
PYH2_k127_1673857_6 COG0110 Acetyltransferase (isoleucine patch superfamily) - - - 0.000000000000000000000000000000000000000000000002159 181.0
PYH2_k127_1673857_7 LemA family K03744 - - 0.000000000000000000000000000000000008987 143.0
PYH2_k127_1673857_8 Methanol dehydrogenase K06872 - - 0.0000000000000000000000000001625 124.0
PYH2_k127_1673857_9 Cytotoxic translational repressor of toxin-antitoxin stability system K06218 - - 0.000000000000000000000005104 103.0
PYH2_k127_1700656_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169,K00186 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 423.0
PYH2_k127_1700656_1 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 323.0
PYH2_k127_1700656_10 TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000009192 206.0
PYH2_k127_1700656_11 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000002103 138.0
PYH2_k127_1700656_12 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000021 113.0
PYH2_k127_1700656_13 PFAM peptidase M6, immune inhibitor A - - - 0.000000000000000000003479 110.0
PYH2_k127_1700656_2 transmembrane transport K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 327.0
PYH2_k127_1700656_3 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 323.0
PYH2_k127_1700656_4 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003997 278.0
PYH2_k127_1700656_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000001343 250.0
PYH2_k127_1700656_6 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000009959 250.0
PYH2_k127_1700656_7 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000005383 249.0
PYH2_k127_1700656_8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000002106 231.0
PYH2_k127_1700656_9 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000006331 223.0
PYH2_k127_1809796_0 aspartate--ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 558.0
PYH2_k127_1809796_1 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001546 267.0
PYH2_k127_1809796_2 Rubrerythrin - - - 0.00000000000000000000000000000000000003468 150.0
PYH2_k127_1809796_3 Rubrerythrin - - - 0.0000000000000000000000000000000000003113 146.0
PYH2_k127_1840407_0 MCM OB domain K10726 - - 4.635e-199 644.0
PYH2_k127_1840407_1 NMD3 family K07562 - - 0.0000000000000000000000000000000000000000907 159.0
PYH2_k127_1840407_2 Protein of unknown function (DUF424) K09148 - - 0.0000000000000000000007986 102.0
PYH2_k127_1840407_3 - - - - 0.0000000000000006551 82.0
PYH2_k127_1840407_4 Double zinc ribbon - - - 0.000686 44.0
PYH2_k127_1949846_0 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 465.0
PYH2_k127_1949846_1 Dehydrogenase K00248,K11410,K18244 GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 456.0
PYH2_k127_1949846_10 Tetratricopeptide TPR_2 repeat protein K06877 - - 0.000000000000000000000000001854 131.0
PYH2_k127_1949846_11 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000001244 111.0
PYH2_k127_1949846_12 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000001452 108.0
PYH2_k127_1949846_2 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 441.0
PYH2_k127_1949846_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 395.0
PYH2_k127_1949846_4 UvrD REP helicase K03657,K07465 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 373.0
PYH2_k127_1949846_5 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 332.0
PYH2_k127_1949846_6 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 305.0
PYH2_k127_1949846_7 mevalonate kinase activity K00869,K15633 GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006066,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006694,GO:0006695,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016126,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653 2.7.1.36,5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000008841 243.0
PYH2_k127_1949846_8 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000001093 159.0
PYH2_k127_1949846_9 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000008856 124.0
PYH2_k127_1997678_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000008249 232.0
PYH2_k127_1997678_1 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000003672 139.0
PYH2_k127_2008207_0 DEAD/H associated K03724 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.0 1452.0
PYH2_k127_2008207_1 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 348.0
PYH2_k127_2010248_0 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007326 426.0
PYH2_k127_2010248_1 Protein of unknown function (DUF763) K09003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 319.0
PYH2_k127_2010248_2 RmlD substrate binding domain K01784,K02473,K03274,K08678 - 4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001991 286.0
PYH2_k127_2055756_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000014 277.0
PYH2_k127_2055756_1 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004803 259.0
PYH2_k127_2055756_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000001075 213.0
PYH2_k127_2055756_3 - - - - 0.000000000000000000000000000000000000000000000000000000001122 219.0
PYH2_k127_2055756_4 EamA-like transporter family - - - 0.0000000000000000000000000004898 117.0
PYH2_k127_2055756_5 Periplasmic copper-binding protein (NosD) - - - 0.00002931 57.0
PYH2_k127_211492_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 622.0
PYH2_k127_2135876_0 Integrin alpha (beta-propellor repeats). - - - 0.000000000000000000000000000022 138.0
PYH2_k127_2135876_1 guanyl-nucleotide exchange factor activity K01406,K20276,K21449 - 3.4.24.40 0.000000000000000000004101 110.0
PYH2_k127_2135876_2 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.00000000000000000001461 108.0
PYH2_k127_2135876_3 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 0.000000000000000003333 98.0
PYH2_k127_2135876_4 amine dehydrogenase activity - - - 0.00005849 57.0
PYH2_k127_2223767_0 cellulase activity - - - 0.00000000000000000000000000000000009371 153.0
PYH2_k127_2223767_1 PFAM PKD domain containing protein - - - 0.00000000002937 77.0
PYH2_k127_2279179_0 Radical_SAM C-terminal domain K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 591.0
PYH2_k127_2279179_1 synthetase (class II) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 383.0
PYH2_k127_2279179_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000000003256 213.0
PYH2_k127_2279179_3 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000771 165.0
PYH2_k127_2279179_4 SMART Ras small GTPase, Ras type - - - 0.0000000000000000000000000000002145 134.0
PYH2_k127_2279179_5 PFAM PKD domain containing protein - - - 0.0000000000000000000000005176 122.0
PYH2_k127_2279179_6 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000009116 89.0
PYH2_k127_2279179_7 - - - - 0.0000000000000001119 80.0
PYH2_k127_2279179_8 OmpA family - - - 0.0000000224 68.0
PYH2_k127_2295488_0 von Willebrand factor, type A - - - 0.0000000000000000003629 104.0
PYH2_k127_2297430_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 8.364e-317 981.0
PYH2_k127_2297430_1 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000006821 198.0
PYH2_k127_2336295_0 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000002904 84.0
PYH2_k127_2336295_1 Lamin Tail Domain - - - 0.0002755 55.0
PYH2_k127_2336295_2 cell adhesion involved in biofilm formation - - - 0.0004779 54.0
PYH2_k127_2347093_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000001704 211.0
PYH2_k127_2347093_1 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000000000000002032 157.0
PYH2_k127_2419717_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000009708 236.0
PYH2_k127_2419717_1 S53, subtilisin kexin sedolisin - - - 0.0002099 55.0
PYH2_k127_2445442_0 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 2.018e-310 977.0
PYH2_k127_2445442_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 407.0
PYH2_k127_2445442_10 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.0000000000000000000000000000000000000000002611 164.0
PYH2_k127_2445442_11 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000000000005526 127.0
PYH2_k127_2445442_12 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000000329 128.0
PYH2_k127_2445442_13 - - - - 0.000000000000000000000000513 109.0
PYH2_k127_2445442_14 Ribosomal protein L11 methyltransferase (PrmA) K07579 - - 0.000000000000000000000008645 104.0
PYH2_k127_2445442_15 Sulfatase-modifying factor enzyme 1 K01176,K01206,K01218,K01219,K01224 - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 0.0000000000000002298 94.0
PYH2_k127_2445442_16 - - - - 0.0000000000001447 75.0
PYH2_k127_2445442_17 BNR repeat-containing family member - - - 0.000000003509 71.0
PYH2_k127_2445442_18 alginic acid biosynthetic process - - - 0.000000005006 71.0
PYH2_k127_2445442_19 - K21029 - 2.7.7.80 0.00000007156 57.0
PYH2_k127_2445442_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 370.0
PYH2_k127_2445442_3 UBA THIF-type NAD FAD binding protein K03148,K21029 - 2.7.7.73,2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 343.0
PYH2_k127_2445442_4 Serine hydroxymethyltransferase K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 316.0
PYH2_k127_2445442_5 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001798 282.0
PYH2_k127_2445442_6 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001289 269.0
PYH2_k127_2445442_7 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003368 256.0
PYH2_k127_2445442_8 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000006424 252.0
PYH2_k127_2445442_9 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000001436 224.0
PYH2_k127_2521815_0 PFAM TfoX N-terminal domain K07343 - - 0.000000000000000000000008838 105.0
PYH2_k127_2521815_1 - - - - 0.000000001982 64.0
PYH2_k127_2551857_0 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 347.0
PYH2_k127_2551857_1 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000184 153.0
PYH2_k127_262200_1 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000002957 176.0
PYH2_k127_262200_2 PFAM SMF family protein K04096 - - 0.00000000000000000000000000000000000000003982 161.0
PYH2_k127_262200_3 NADPH-dependent FMN reductase - - - 0.0000000000000000003959 90.0
PYH2_k127_262200_4 - - - - 0.000000000000000003955 91.0
PYH2_k127_262200_5 CDP-alcohol phosphatidyltransferase - - - 0.00000001375 63.0
PYH2_k127_2650038_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 0.0 1165.0
PYH2_k127_2650038_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 370.0
PYH2_k127_2650038_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000001274 106.0
PYH2_k127_2650038_3 membrane - - - 0.0000000000000001254 89.0
PYH2_k127_2682651_0 Bacterial Ig-like domain (group 3) K20276 - - 0.00000000000003394 87.0
PYH2_k127_2692877_0 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000001166 207.0
PYH2_k127_2692877_1 Protein kinase domain K08851,K15904 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234,2.7.11.1 0.00000000000000000000000000000000000000005225 160.0
PYH2_k127_2699873_0 pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 480.0
PYH2_k127_2699873_1 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 291.0
PYH2_k127_2699873_2 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004393 278.0
PYH2_k127_2699873_3 NADH ubiquinone oxidoreductase, 20 Kd subunit K00331,K22159 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000005465 203.0
PYH2_k127_2699873_4 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000000000000000000000000000002668 134.0
PYH2_k127_2699873_5 PFAM Protein kinase domain - - - 0.0000000000000000000000000003249 131.0
PYH2_k127_2699873_6 Transcriptional regulator, TrmB - - - 0.00000000000000000002886 104.0
PYH2_k127_2699873_7 transcriptional regulator, ArsR family K07013 - - 0.0000000000007446 80.0
PYH2_k127_2711079_0 Malic enzyme, NAD binding domain K00027,K00029 - 1.1.1.38,1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 582.0
PYH2_k127_2711079_1 - - - - 0.00000000000000000000000000002927 119.0
PYH2_k127_2711079_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000006799 94.0
PYH2_k127_2711079_3 Predicted membrane protein (DUF2085) - - - 0.00000000000000000001826 99.0
PYH2_k127_2748567_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 488.0
PYH2_k127_2748567_1 PFAM tRNA methyltransferase complex GCD14 subunit K07442 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0031515,GO:0032991,GO:0034708,GO:0043527,GO:0044424,GO:0044444,GO:0044464,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000001013 177.0
PYH2_k127_2757186_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 343.0
PYH2_k127_2757186_1 Subtilase family K01342 - 3.4.21.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 314.0
PYH2_k127_2757186_2 SMART ATPase, AAA type, core K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 294.0
PYH2_k127_2757186_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000003597 162.0
PYH2_k127_2757186_4 domain protein K20276 - - 0.00000000000000000000008823 115.0
PYH2_k127_2757186_5 protein conserved in archaea - - - 0.000000009454 69.0
PYH2_k127_2757186_6 PFAM ABC-2 type transporter K01992 - - 0.000002218 51.0
PYH2_k127_2795781_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1194.0
PYH2_k127_2795781_1 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 1.302e-288 902.0
PYH2_k127_2795781_10 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000000000000008407 151.0
PYH2_k127_2795781_2 CO dehydrogenase/acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 419.0
PYH2_k127_2795781_3 Cysteine-rich domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009201 368.0
PYH2_k127_2795781_4 Methylene-tetrahydrofolate reductase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003478 263.0
PYH2_k127_2795781_5 GPR1 FUN34 yaaH family protein K07034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005103 243.0
PYH2_k127_2795781_6 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000002387 237.0
PYH2_k127_2795781_7 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000006181 205.0
PYH2_k127_2795781_8 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.00000000000000000000000000000000000000000000000000000001564 202.0
PYH2_k127_2795781_9 Domain of unknown function - - - 0.0000000000000000000000000000000000000000000000000000002427 203.0
PYH2_k127_2800973_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000001388 205.0
PYH2_k127_2800973_1 Thiamine-binding protein - - - 0.0000000000000000000009058 98.0
PYH2_k127_2800973_2 SPTR CHU large protein - - - 0.0000000000003756 84.0
PYH2_k127_2800973_3 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K06976 - - 0.00000003731 65.0
PYH2_k127_2800973_4 Peptidase family M28 - - - 0.0000006163 64.0
PYH2_k127_2814539_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 482.0
PYH2_k127_2814539_1 PFAM UspA domain protein - - - 0.000000000000000001046 91.0
PYH2_k127_2877053_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009104 587.0
PYH2_k127_2877053_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 480.0
PYH2_k127_2877053_10 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000003662 128.0
PYH2_k127_2877053_11 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000005867 109.0
PYH2_k127_2877053_12 Tubulin like - - - 0.0000000000000000000001669 115.0
PYH2_k127_2877053_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000003891 97.0
PYH2_k127_2877053_14 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000002422 88.0
PYH2_k127_2877053_15 - - - - 0.00000000000000002173 82.0
PYH2_k127_2877053_16 Domain of unknown function DUF11 - - - 0.00000000000007286 87.0
PYH2_k127_2877053_17 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000008677 83.0
PYH2_k127_2877053_18 - - - - 0.00000007905 63.0
PYH2_k127_2877053_19 Transcriptional regulator, AbrB family - - - 0.000001503 55.0
PYH2_k127_2877053_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 431.0
PYH2_k127_2877053_3 Belongs to the MEMO1 family K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007621 310.0
PYH2_k127_2877053_4 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 299.0
PYH2_k127_2877053_5 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 293.0
PYH2_k127_2877053_6 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000000000000000001085 196.0
PYH2_k127_2877053_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000003105 152.0
PYH2_k127_2877053_8 amine dehydrogenase activity K20276 - - 0.00000000000000000000000000000000000791 160.0
PYH2_k127_2877053_9 RNA polymerase subunit 9 K03057 - - 0.000000000000000000000000001099 120.0
PYH2_k127_2882017_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 412.0
PYH2_k127_2882017_1 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 368.0
PYH2_k127_2882017_10 - - - - 0.0000958 51.0
PYH2_k127_2882017_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 352.0
PYH2_k127_2882017_3 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 303.0
PYH2_k127_2882017_4 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.00000000000000000000000000001288 123.0
PYH2_k127_2882017_6 AIG2-like family - - - 0.0000000002053 68.0
PYH2_k127_2882017_7 PIN domain - - - 0.000000005027 64.0
PYH2_k127_2882017_8 - - - - 0.00000007365 56.0
PYH2_k127_2882017_9 - - - - 0.00005225 54.0
PYH2_k127_2901109_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 398.0
PYH2_k127_2901109_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005204 269.0
PYH2_k127_2915277_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 443.0
PYH2_k127_2915277_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000006804 247.0
PYH2_k127_2915277_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000008214 71.0
PYH2_k127_2915277_2 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000001309 199.0
PYH2_k127_2915277_3 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.0000000000000000000000000000000000000000000001181 175.0
PYH2_k127_2915277_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.0000000000000000000000000000000000000002031 160.0
PYH2_k127_2915277_5 Ribosomal protein S8e K02995 GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.000000000000000000000000000000002242 132.0
PYH2_k127_2915277_6 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.00000000000000000000000000003723 133.0
PYH2_k127_2915277_7 - - - - 0.000000000000000000000000006318 119.0
PYH2_k127_2915277_8 Uncharacterized ArCR, COG1888 K09732 - - 0.000000000000000000000000208 108.0
PYH2_k127_2915277_9 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000007823 91.0
PYH2_k127_2925325_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 317.0
PYH2_k127_2925325_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000005271 151.0
PYH2_k127_2925325_2 AAA domain - - - 0.0000000000000000000000000000000000006395 158.0
PYH2_k127_2925325_3 ribosomal small subunit binding - - - 0.000000000132 70.0
PYH2_k127_294697_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 8.033e-256 811.0
PYH2_k127_294697_1 Oxidoreductase, short chain dehydrogenase reductase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001002 280.0
PYH2_k127_294697_2 - - - - 0.00000752 52.0
PYH2_k127_2961660_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 4.367e-214 677.0
PYH2_k127_2961660_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K09759,K22503 - 6.1.1.12,6.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 508.0
PYH2_k127_2961660_10 protein Sb1211s002020 source - - - 0.0000001347 57.0
PYH2_k127_2961660_13 - - - - 0.0002801 46.0
PYH2_k127_2961660_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 323.0
PYH2_k127_2961660_3 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.000000000000000000000000000000000003058 142.0
PYH2_k127_2961660_5 Uncharacterised protein family UPF0066 - - - 0.0000000000000000005079 93.0
PYH2_k127_2961660_6 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000000002 88.0
PYH2_k127_2961660_8 - - - - 0.000000001481 60.0
PYH2_k127_2997757_0 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.0000000000000000000000000000000000000000000000000000000000001063 220.0
PYH2_k127_2997757_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000002393 191.0
PYH2_k127_2997757_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000001139 194.0
PYH2_k127_2997757_3 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000002568 146.0
PYH2_k127_2997757_4 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000009001 118.0
PYH2_k127_2997757_5 PIN domain - - - 0.0001317 49.0
PYH2_k127_3018402_0 TIGRFAM conserved repeat domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 321.0
PYH2_k127_3018402_1 TIGRFAM methyltransferase FkbM - - - 0.00000000000000000002288 106.0
PYH2_k127_3060346_0 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 318.0
PYH2_k127_3060346_1 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000537 203.0
PYH2_k127_3060346_2 Methyltransferase type 12 - - - 0.00000000000000000000000749 111.0
PYH2_k127_3061711_0 PFAM NAD dependent epimerase dehydratase family K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000001875 206.0
PYH2_k127_3061711_1 PFAM isochorismatase hydrolase - - - 0.0000000000000000000000000000000000000000000359 167.0
PYH2_k127_3061711_2 cytochrome c biogenesis protein K06196 - - 0.0000000000003557 78.0
PYH2_k127_3061711_3 COG0457 FOG TPR repeat - - - 0.0003227 52.0
PYH2_k127_3118986_0 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000001444 117.0
PYH2_k127_3118986_1 Belongs to the peptidase S8 family - GO:0005575,GO:0005623,GO:0031975,GO:0044464 - 0.00000000000000002388 95.0
PYH2_k127_3118986_2 PKD domain K01183 - 3.2.1.14 0.0000000001041 75.0
PYH2_k127_3118986_3 NACHT domain - - - 0.00000009843 64.0
PYH2_k127_317875_0 helicase superfamily c-terminal domain K03724 - - 6.103e-254 811.0
PYH2_k127_317875_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 552.0
PYH2_k127_317875_10 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000002358 174.0
PYH2_k127_317875_11 PFAM SOUL heme-binding protein - - - 0.0000000000000000000000000000006613 128.0
PYH2_k127_317875_12 Alpha/beta hydrolase family - - - 0.00000000000000000000000000159 125.0
PYH2_k127_317875_13 - - - - 0.0000000000000000000000001272 107.0
PYH2_k127_317875_14 - - - - 0.0000000000000000000000009174 104.0
PYH2_k127_317875_15 protein conserved in archaea - - - 0.0000000000000000002521 102.0
PYH2_k127_317875_16 - - - - 0.00000000000000001001 97.0
PYH2_k127_317875_17 Protein of unknown function (DUF1634) - - - 0.0001185 49.0
PYH2_k127_317875_2 saccharopine dehydrogenase activity K19064 - 1.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 424.0
PYH2_k127_317875_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 409.0
PYH2_k127_317875_4 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007758 406.0
PYH2_k127_317875_5 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 333.0
PYH2_k127_317875_6 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 302.0
PYH2_k127_317875_7 PFAM glycosyl transferase group 1 K12995 - 2.4.1.348 0.0000000000000000000000000000000000000000000000000009058 198.0
PYH2_k127_317875_9 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000218 190.0
PYH2_k127_3238884_0 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000002127 98.0
PYH2_k127_3238884_1 Evidence 5 No homology to any previously reported sequences - - - 0.0003565 53.0
PYH2_k127_3298661_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 352.0
PYH2_k127_3298661_1 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000002536 156.0
PYH2_k127_3298661_2 KR domain - - - 0.00000000000004836 73.0
PYH2_k127_3298661_3 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.257 0.0000001654 61.0
PYH2_k127_3298661_4 Calcineurin-like phosphoesterase - - - 0.000007178 59.0
PYH2_k127_3311848_0 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000204 297.0
PYH2_k127_3311848_1 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001788 289.0
PYH2_k127_3311848_2 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000001172 222.0
PYH2_k127_3311848_3 Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000003677 154.0
PYH2_k127_3311848_4 - - - - 0.00000000000000000000006801 105.0
PYH2_k127_3311848_5 archaeal coiled-coil protein - - - 0.000000000000002874 86.0
PYH2_k127_3311848_6 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.000000000000005222 88.0
PYH2_k127_3312233_0 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 474.0
PYH2_k127_3312233_1 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 387.0
PYH2_k127_3328356_0 Cysteine desulfurase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 386.0
PYH2_k127_3328356_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 317.0
PYH2_k127_3328356_2 membrane protein, required for N-linked glycosylation K07151 GO:0000030,GO:0003674,GO:0003824,GO:0004169,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.99.18 0.0000004875 61.0
PYH2_k127_3362144_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006602 223.0
PYH2_k127_3362144_1 ATPase (AAA superfamily K07133 - - 0.00000000000000000000000000000000000000000000000000000000000005797 230.0
PYH2_k127_3362144_2 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.000000000000000000000000000000000000000000000000000000001084 216.0
PYH2_k127_3362144_3 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00007774 45.0
PYH2_k127_339415_0 oligoendopeptidase F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 378.0
PYH2_k127_339415_1 Uncharacterised protein family (UPF0147) K09721 - - 0.0000000000000000000000008777 106.0
PYH2_k127_339415_2 - - - - 0.000000000000000000001732 97.0
PYH2_k127_3418118_0 PFAM AMP-dependent synthetase and ligase K01907 - 6.2.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 366.0
PYH2_k127_3418118_1 Seven times multi-haem cytochrome CxxCH - - - 0.000000000000000000000000000000000000000000000000000000003924 209.0
PYH2_k127_3454012_0 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 4.127e-297 925.0
PYH2_k127_3454012_1 Nickel-dependent hydrogenase K14126 - 1.8.98.5 7.071e-222 707.0
PYH2_k127_3454012_2 PFAM fumarate reductase succinate dehydrogenase flavoprotein K00239 - 1.3.5.1,1.3.5.4 3.931e-205 660.0
PYH2_k127_3454012_3 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 410.0
PYH2_k127_3454012_4 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 386.0
PYH2_k127_3454012_5 Methyl-viologen-reducing hydrogenase, delta subunit K14127,K14128 - 1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000003903 199.0
PYH2_k127_3454012_6 Fe-S oxidoreductase - - - 0.0000000000000000000000000000000000000000000002726 173.0
PYH2_k127_3454012_7 spore germination K00442,K03605,K04656,K08315 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.23.51 0.000000000000000000000000000001104 126.0
PYH2_k127_3454012_8 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000002762 72.0
PYH2_k127_3486402_0 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000001614 187.0
PYH2_k127_3486402_1 Heavy metal translocating P-type atpase - - - 0.00000000000000000000002052 109.0
PYH2_k127_3486402_2 Sulfatase-modifying factor enzyme 1 K01176,K01206,K01218,K01219,K01224 - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 0.000000000000000005405 100.0
PYH2_k127_3486402_3 cellulase activity - - - 0.000000000004065 80.0
PYH2_k127_3486402_4 Major Facilitator Superfamily K08222 - - 0.000004017 59.0
PYH2_k127_3486402_5 protein conserved in archaea K09723 - - 0.0004832 51.0
PYH2_k127_3491777_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 475.0
PYH2_k127_3491777_1 PFAM Phosphomethylpyrimidine kinase K00941,K21219,K21220 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000331 295.0
PYH2_k127_3491777_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000008504 221.0
PYH2_k127_3491777_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000001717 199.0
PYH2_k127_3491777_4 - - - - 0.0000000000000000000000000000000000000001718 154.0
PYH2_k127_3491777_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000001498 153.0
PYH2_k127_3491777_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000006554 121.0
PYH2_k127_3491777_7 Pfam:DUF552 K09152 - - 0.00000000000000000000000001539 113.0
PYH2_k127_3491777_8 - - - - 0.00000000000000000000000001935 113.0
PYH2_k127_3491777_9 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000005145 88.0
PYH2_k127_3497760_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 4.872e-238 764.0
PYH2_k127_3497760_1 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 351.0
PYH2_k127_3497760_2 Pfam:Methyltransf_26 K07446 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000001574 213.0
PYH2_k127_3518755_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 609.0
PYH2_k127_3518755_1 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000000000000000000000000000000000000002758 235.0
PYH2_k127_3518755_2 signal transduction protein with CBS domains - - - 0.00000000000000000000000000000003014 134.0
PYH2_k127_3518755_3 4Fe-4S binding domain - - - 0.0000000000000000000000002418 111.0
PYH2_k127_3518755_4 PFAM 4-vinyl reductase, 4VR K07013 - - 0.000000000000000000000004696 108.0
PYH2_k127_3518755_5 protein conserved in archaea - - - 0.0000000003748 71.0
PYH2_k127_3518755_6 Roadblock LC7 family protein K07131 - - 0.000000001595 63.0
PYH2_k127_3518755_7 ABC transporter substrate-binding protein K02035 - - 0.00000002357 66.0
PYH2_k127_3518755_8 Double zinc ribbon - - - 0.0006041 51.0
PYH2_k127_3583707_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 557.0
PYH2_k127_3583707_1 Hemerythrin HHE cation binding domain protein K09155 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 452.0
PYH2_k127_3583707_2 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000001256 214.0
PYH2_k127_3583707_3 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000625 189.0
PYH2_k127_3583707_4 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000008154 162.0
PYH2_k127_3583707_5 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.0000000000000000000000000000000000000001718 154.0
PYH2_k127_3583707_6 PFAM Rubredoxin - - - 0.0000000000000000000000008939 105.0
PYH2_k127_3583707_7 PFAM glutaredoxin - - - 0.0000000000000000004607 91.0
PYH2_k127_3623780_0 Ferrous iron transport B domain protein K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 580.0
PYH2_k127_3623780_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K03239,K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 401.0
PYH2_k127_3623780_10 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000002672 100.0
PYH2_k127_3623780_11 DIM6 NTAB family - - - 0.000000000000000002792 87.0
PYH2_k127_3623780_12 Belongs to the UPF0201 family K09736 - - 0.00000000000000001431 88.0
PYH2_k127_3623780_13 - - - - 0.000000000006371 69.0
PYH2_k127_3623780_14 - - - - 0.00000001316 66.0
PYH2_k127_3623780_15 Protein of unknown function (DUF835) - - - 0.0009008 48.0
PYH2_k127_3623780_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 386.0
PYH2_k127_3623780_3 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 301.0
PYH2_k127_3623780_4 FeoA K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000002487 233.0
PYH2_k127_3623780_5 PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000002701 187.0
PYH2_k127_3623780_6 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000615 176.0
PYH2_k127_3623780_7 Transcriptional regulator, AbiEi antitoxin - - - 0.000000000000000000000000000000000001256 147.0
PYH2_k127_3623780_8 Nucleotidyl transferase AbiEii toxin, Type IV TA system K09144 - - 0.000000000000000000000000000000000004523 146.0
PYH2_k127_3623780_9 CAAX protease self-immunity - - - 0.0000000000000000000000000002171 128.0
PYH2_k127_3673691_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 381.0
PYH2_k127_3673691_1 TPR Domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 342.0
PYH2_k127_3673691_2 Uncharacterised protein family (UPF0179) K09730 - - 0.0000000000000000000000000000008459 137.0
PYH2_k127_3673691_3 Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin K21232 - - 0.00000000000001263 77.0
PYH2_k127_3673691_4 - - - - 0.00000001102 66.0
PYH2_k127_3673691_5 Fungalysin metallopeptidase (M36) - - - 0.0000002065 57.0
PYH2_k127_3673691_6 - - - - 0.0001013 51.0
PYH2_k127_3673691_7 - - - - 0.0005322 49.0
PYH2_k127_3731680_0 Integrin alpha (beta-propellor repeats). - - - 0.0000000000000000000000000007259 132.0
PYH2_k127_3731680_1 intracellular protein transport K05989 - 3.2.1.40 0.000000004355 70.0
PYH2_k127_3745526_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 338.0
PYH2_k127_3745526_1 PFAM methyltransferase small K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.297 0.0000000000000000000000000001534 124.0
PYH2_k127_3745526_2 PFAM Rhomboid family protein - - - 0.000000000000000001874 96.0
PYH2_k127_3746065_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03237 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 330.0
PYH2_k127_3746065_1 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001131 282.0
PYH2_k127_3746065_2 Binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000009222 137.0
PYH2_k127_3746065_3 Transcriptional regulator, ArsR family - - - 0.000000000000000000000000003559 118.0
PYH2_k127_3746065_4 PAS domain K02488 - 2.7.7.65 0.000000000000001804 85.0
PYH2_k127_3746065_5 Ribosomal protein S27E K02978 - - 0.000000000000437 76.0
PYH2_k127_3746065_6 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000457 68.0
PYH2_k127_3769723_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1020.0
PYH2_k127_3769723_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000001032 145.0
PYH2_k127_3769723_2 Acylphosphatase - - - 0.0000001354 61.0
PYH2_k127_3778887_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005837 263.0
PYH2_k127_3778887_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000006484 239.0
PYH2_k127_3778887_2 Predicted membrane protein (DUF2318) - - - 0.0000000000000000000000003245 112.0
PYH2_k127_3778887_3 Transcriptional regulator - - - 0.00000000000000000002847 94.0
PYH2_k127_3778887_4 - - - - 0.00000000001501 73.0
PYH2_k127_3983554_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001175 267.0
PYH2_k127_3983554_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000009417 139.0
PYH2_k127_3983554_2 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000591 94.0
PYH2_k127_3983554_3 - - - - 0.0000000000000000001704 95.0
PYH2_k127_4056511_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 429.0
PYH2_k127_4056511_1 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000003984 174.0
PYH2_k127_4056511_2 Peptidyl-tRNA hydrolase PTH2 K04794 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.29 0.000000000000000000000000000000004443 131.0
PYH2_k127_4056511_3 Protein of unknown function (DUF1616) - - - 0.000000000000000000001114 102.0
PYH2_k127_4056511_4 tetratricopeptide repeat - - - 0.000000005042 64.0
PYH2_k127_4056511_5 - - - - 0.0000001598 59.0
PYH2_k127_4056511_6 Nucleotidyltransferase domain K07076 - - 0.00002083 47.0
PYH2_k127_4056511_7 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.00003529 49.0
PYH2_k127_4063356_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 404.0
PYH2_k127_4063356_1 Beta-lactamase superfamily domain K06136 - - 0.000000000000000000000000000000000000000000000000000004136 204.0
PYH2_k127_4063356_2 phosphoprotein phosphatase activity K07313 - 3.1.3.16 0.0000000000000000000000000000000000000001547 162.0
PYH2_k127_4063356_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767 - 5.2.1.8 0.00000000000000000000000000000000002817 140.0
PYH2_k127_4063356_4 - - - - 0.000008319 57.0
PYH2_k127_4067749_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.194e-197 631.0
PYH2_k127_4067749_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000001024 94.0
PYH2_k127_4075457_0 tRNA intron endonuclease, catalytic C-terminal domain K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 296.0
PYH2_k127_4075457_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000000002605 177.0
PYH2_k127_4075457_3 - - - - 0.0005 48.0
PYH2_k127_4086805_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 504.0
PYH2_k127_4086805_1 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009212 487.0
PYH2_k127_4086805_2 PFAM PHP domain protein - - - 0.00000000000000000000000000000000002796 138.0
PYH2_k127_4172585_0 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 609.0
PYH2_k127_4172585_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 534.0
PYH2_k127_4172585_10 GCN5 family acetyltransferase - - - 0.00000000000000000000000000000000000002484 160.0
PYH2_k127_4172585_11 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000004488 138.0
PYH2_k127_4172585_12 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000005858 147.0
PYH2_k127_4172585_13 - - - - 0.00000000000000003206 83.0
PYH2_k127_4172585_14 - K00960 - 2.7.7.6 0.00000000000001134 74.0
PYH2_k127_4172585_15 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0000000001254 72.0
PYH2_k127_4172585_16 TIGRFAM Outer membrane protein K13735,K20276 - - 0.0000000001441 76.0
PYH2_k127_4172585_17 PA14 domain - - - 0.000000006767 70.0
PYH2_k127_4172585_2 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 366.0
PYH2_k127_4172585_3 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 359.0
PYH2_k127_4172585_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 311.0
PYH2_k127_4172585_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 317.0
PYH2_k127_4172585_6 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992,K19341 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 297.0
PYH2_k127_4172585_7 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004083 278.0
PYH2_k127_4172585_8 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001304 267.0
PYH2_k127_4172585_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000002118 265.0
PYH2_k127_4186392_0 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 327.0
PYH2_k127_4186392_1 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000005217 192.0
PYH2_k127_4186392_2 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000002039 178.0
PYH2_k127_4186392_3 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000008562 130.0
PYH2_k127_4186392_4 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000004451 120.0
PYH2_k127_4186392_5 Protein of unknown function (DUF402) K09145 - - 0.0000000000000000000013 101.0
PYH2_k127_4186392_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000008664 90.0
PYH2_k127_4186392_7 domain protein K20276 - - 0.0000000000000000169 94.0
PYH2_k127_4186392_8 PFAM CBS domain containing protein - - - 0.00000000000000002381 94.0
PYH2_k127_4217963_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1023.0
PYH2_k127_4217963_1 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 408.0
PYH2_k127_4217963_2 Rubrerythrin - - - 0.00000000000000000000000000000005369 131.0
PYH2_k127_4217963_3 pfam yhs - - - 0.00000000000000000302 85.0
PYH2_k127_4296263_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000006811 59.0
PYH2_k127_4329160_0 cyclic 2,3-diphosphoglycerate synthetase activity K05716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 607.0
PYH2_k127_4329160_1 Domain of unknown function (DUF296) K06934 - - 0.0000000000001637 75.0
PYH2_k127_4329160_2 - - - - 0.00000000000148 73.0
PYH2_k127_4329160_3 Major facilitator superfamily domain containing 11 - - - 0.0000002553 63.0
PYH2_k127_4352101_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 507.0
PYH2_k127_4352101_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 337.0
PYH2_k127_4352101_2 deoxyribonuclease I activity K06131,K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 344.0
PYH2_k127_4352101_3 TIGRFAM CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005084 286.0
PYH2_k127_4352101_4 Glucose / Sorbosone dehydrogenase - - - 0.0000004067 64.0
PYH2_k127_4461844_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006441 459.0
PYH2_k127_4461844_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 411.0
PYH2_k127_4461844_10 - - - - 0.00000000000000000007426 97.0
PYH2_k127_4461844_11 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000000000167 75.0
PYH2_k127_4461844_12 Integrin alpha (beta-propellor repeats). - - - 0.000000001922 72.0
PYH2_k127_4461844_13 von Willebrand factor, type A K07114 - - 0.00000001005 69.0
PYH2_k127_4461844_14 Protein of unknown function DUF131 - - - 0.00000006243 61.0
PYH2_k127_4461844_15 SpoVT / AbrB like domain - - - 0.000001063 55.0
PYH2_k127_4461844_16 primary miRNA processing - GO:0000375,GO:0000377,GO:0000398,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006366,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008283,GO:0008380,GO:0009058,GO:0009059,GO:0009301,GO:0009605,GO:0009607,GO:0009617,GO:0009889,GO:0009892,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010556,GO:0010605,GO:0010608,GO:0010629,GO:0010720,GO:0014070,GO:0016070,GO:0016071,GO:0016073,GO:0016246,GO:0016441,GO:0016458,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019827,GO:0022008,GO:0030154,GO:0030422,GO:0031047,GO:0031050,GO:0031053,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032774,GO:0032991,GO:0033168,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035194,GO:0035195,GO:0035196,GO:0036404,GO:0040029,GO:0042221,GO:0042742,GO:0042795,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043331,GO:0043900,GO:0043901,GO:0043903,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045069,GO:0045071,GO:0045595,GO:0045597,GO:0046483,GO:0046685,GO:0048518,GO:0048519,GO:0048522,GO:0048525,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050792,GO:0050793,GO:0050794,GO:0050829,GO:0050896,GO:0051094,GO:0051171,GO:0051239,GO:0051240,GO:0051252,GO:0051704,GO:0051707,GO:0051716,GO:0051960,GO:0051962,GO:0060255,GO:0060284,GO:0065007,GO:0070013,GO:0070887,GO:0070918,GO:0071310,GO:0071359,GO:0071407,GO:0071704,GO:0080090,GO:0090304,GO:0097150,GO:0097159,GO:0097659,GO:0098542,GO:0098727,GO:0098781,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901698,GO:1901699,GO:1903506,GO:1903900,GO:1903901,GO:2000026,GO:2000112,GO:2001141 - 0.0003276 44.0
PYH2_k127_4461844_2 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 313.0
PYH2_k127_4461844_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 311.0
PYH2_k127_4461844_4 Helix-turn-helix XRE-family like proteins K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004966 267.0
PYH2_k127_4461844_5 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000009973 242.0
PYH2_k127_4461844_6 Transcription elongation factor Spt5 K02601 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000002097 213.0
PYH2_k127_4461844_7 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000001408 181.0
PYH2_k127_4461844_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000001572 167.0
PYH2_k127_4461844_9 PIN domain - - - 0.000000000000000000001021 101.0
PYH2_k127_449538_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 429.0
PYH2_k127_449538_1 Belongs to the eukaryotic ribosomal protein eS1 family K02984 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000003184 171.0
PYH2_k127_449538_2 peptidase U32 K08303 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000005488 84.0
PYH2_k127_449538_3 Parallel beta-helix repeats - - - 0.0000003193 56.0
PYH2_k127_4508349_0 ThiF family K12164 - - 0.0000000000000000000000000000000000000000000000000000426 203.0
PYH2_k127_4508349_1 anaphase-promoting complex binding K03466,K06196,K12132 - 2.7.11.1 0.000000000000000000000000002115 133.0
PYH2_k127_4508349_2 enzyme 1 K12165 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0019538,GO:0019787,GO:0032446,GO:0033554,GO:0034976,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070647,GO:0071568,GO:0071569,GO:0071704,GO:0140096,GO:1901564,GO:1990564,GO:1990592 - 0.00000000002707 70.0
PYH2_k127_4508349_3 Belongs to the peptidase S8 family K01361,K08652,K14647 GO:0005575,GO:0005576 3.4.21.110,3.4.21.96 0.00000005517 68.0
PYH2_k127_4508349_4 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.00003982 59.0
PYH2_k127_4508349_5 amine dehydrogenase activity - - - 0.00009065 58.0
PYH2_k127_4535220_0 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 7.46e-238 746.0
PYH2_k127_4535220_1 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001736 259.0
PYH2_k127_4535220_2 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000007746 208.0
PYH2_k127_4546501_0 helicase superfamily c-terminal domain K10896 - - 1.16e-219 706.0
PYH2_k127_4546501_1 GrpB protein - - - 0.00000000000000000000000000000000001745 143.0
PYH2_k127_4546501_2 AAA domain K07133 - - 0.00000000000000000000000000009375 131.0
PYH2_k127_4546501_3 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000002297 66.0
PYH2_k127_4546501_4 MFS_1 like family - - - 0.000000001199 68.0
PYH2_k127_4585939_0 Proton-conducting membrane transporter K22168 - 1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 410.0
PYH2_k127_4585939_1 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 - 1.6.5.3 0.000000000000000000000004287 107.0
PYH2_k127_4585939_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000937 73.0
PYH2_k127_459669_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000001305 220.0
PYH2_k127_459669_1 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.00000000000000000000000000000000000000000001436 172.0
PYH2_k127_459669_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000003323 176.0
PYH2_k127_459669_3 YoaP-like - - - 0.0000000002786 70.0
PYH2_k127_4724574_0 Protein kinase domain - - - 0.00000000000000000000000000000000000003476 154.0
PYH2_k127_4724574_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000002242 108.0
PYH2_k127_4726771_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 507.0
PYH2_k127_4726771_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 437.0
PYH2_k127_4726771_10 - - - - 0.00000000000000009347 87.0
PYH2_k127_4726771_11 Antidote-toxin recognition MazE, bacterial antitoxin - - - 0.00000000000005947 74.0
PYH2_k127_4726771_12 LexA-binding, inner membrane-associated putative hydrolase - - - 0.0000000000008959 76.0
PYH2_k127_4726771_13 - - - - 0.0000000001766 65.0
PYH2_k127_4726771_14 - - - - 0.00000001436 58.0
PYH2_k127_4726771_15 membrane - - - 0.0000005346 59.0
PYH2_k127_4726771_16 COG0456 Acetyltransferases K03789 - 2.3.1.128 0.000002466 59.0
PYH2_k127_4726771_17 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0001208 53.0
PYH2_k127_4726771_2 ATPase, AAA superfamily K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 412.0
PYH2_k127_4726771_3 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006336 413.0
PYH2_k127_4726771_4 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 313.0
PYH2_k127_4726771_5 Nucleolar GTP-binding protein 1 (NOG1) K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002301 284.0
PYH2_k127_4726771_6 Fibronectin type III domain - - - 0.000000000000000000000000000000000000000000000001268 200.0
PYH2_k127_4726771_7 nucleotide metabolic process - - - 0.000000000000000000000000000000000000004116 158.0
PYH2_k127_4726771_8 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000006954 137.0
PYH2_k127_4726771_9 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000001294 119.0
PYH2_k127_4773628_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 5.009e-219 693.0
PYH2_k127_4773628_1 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 419.0
PYH2_k127_4773628_10 - - - - 0.0000000000000000001378 93.0
PYH2_k127_4773628_11 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000004269 93.0
PYH2_k127_4773628_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000002547 89.0
PYH2_k127_4773628_13 cobalamin transport - - - 0.00000000000000713 89.0
PYH2_k127_4773628_14 PKD domain - - - 0.00000000000001641 87.0
PYH2_k127_4773628_15 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000001557 74.0
PYH2_k127_4773628_16 PFAM regulatory protein, ArsR - - - 0.000000000004278 76.0
PYH2_k127_4773628_17 - - - - 0.00000000005491 68.0
PYH2_k127_4773628_18 alginic acid biosynthetic process K01729,K17713 - 4.2.2.3 0.00000001741 68.0
PYH2_k127_4773628_19 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000002173 59.0
PYH2_k127_4773628_2 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 379.0
PYH2_k127_4773628_20 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000009747 57.0
PYH2_k127_4773628_3 COG0003 Oxyanion-translocating ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 350.0
PYH2_k127_4773628_4 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 K03049 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000001717 212.0
PYH2_k127_4773628_5 Putative Fe-S cluster - - - 0.0000000000000000000000000027 121.0
PYH2_k127_4773628_6 ParB-like nuclease domain - - - 0.00000000000000000000000008977 111.0
PYH2_k127_4773628_7 DGC domain - - - 0.0000000000000000000001796 102.0
PYH2_k127_4773628_8 Belongs to the UPF0218 family K09735 - - 0.0000000000000000000004898 103.0
PYH2_k127_4773628_9 PRC-barrel domain - - - 0.0000000000000000001005 93.0
PYH2_k127_4773739_0 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000002432 249.0
PYH2_k127_4773739_1 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000004413 223.0
PYH2_k127_4773739_2 PFAM GvpD gas vesicle - - - 0.00000000000000000000000000000000000000000000000000191 201.0
PYH2_k127_4773739_3 Roadblock LC7 family protein K07131 - - 0.0000000000000001034 84.0
PYH2_k127_4811491_0 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000001688 213.0
PYH2_k127_4811491_1 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000009574 202.0
PYH2_k127_4811491_2 ATP-grasp domain K22224 - 6.2.1.13 0.000000000000000000000000000000000000000005219 160.0
PYH2_k127_4811491_3 Radical SAM superfamily - - - 0.000000000000000000000000000003351 134.0
PYH2_k127_4818789_0 PFAM Transketolase K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 388.0
PYH2_k127_4818789_1 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 376.0
PYH2_k127_4818789_2 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 371.0
PYH2_k127_4818789_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 321.0
PYH2_k127_4818789_4 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 321.0
PYH2_k127_4818789_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000002655 235.0
PYH2_k127_4818789_6 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000001636 230.0
PYH2_k127_4818789_7 SMART Ras small GTPase, Ras type - - - 0.000000000000000000000000000000009901 134.0
PYH2_k127_4818789_8 TPR Domain containing protein - - - 0.000000000000000000000000006062 120.0
PYH2_k127_4818789_9 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000001384 87.0
PYH2_k127_4876013_0 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000966 434.0
PYH2_k127_4876013_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 401.0
PYH2_k127_4876013_10 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.5.1.114 0.0000000000000000000000000000000000000000000000921 173.0
PYH2_k127_4876013_11 O-methyltransferase - - - 0.00000000000000000000000000000000000000001668 165.0
PYH2_k127_4876013_12 4Fe-4S dicluster domain K00188 - 1.2.7.7 0.000000000000000000000004297 104.0
PYH2_k127_4876013_13 cellulase activity - - - 0.0001038 56.0
PYH2_k127_4876013_2 Hydrolyase tartrate alpha subunit fumarate domain protein Fe-S type K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 369.0
PYH2_k127_4876013_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 333.0
PYH2_k127_4876013_4 AP endonuclease family 2 K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 298.0
PYH2_k127_4876013_5 Fibronectin type III domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 315.0
PYH2_k127_4876013_6 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000002871 277.0
PYH2_k127_4876013_7 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000001118 252.0
PYH2_k127_4876013_8 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000006572 226.0
PYH2_k127_4876013_9 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K00189 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000003019 216.0
PYH2_k127_4946043_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007128 270.0
PYH2_k127_4946043_1 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000004311 211.0
PYH2_k127_4989502_0 TIGRFAM geranylgeranyl reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004469 261.0
PYH2_k127_4989502_1 Archaeal transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000000000000000000000000000001024 238.0
PYH2_k127_4989502_2 Protein of unknown function (DUF835) - - - 0.00000000005237 76.0
PYH2_k127_4999247_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000000000000000000000002214 228.0
PYH2_k127_4999247_1 - - - - 0.000000000000000000000000000000001431 153.0
PYH2_k127_4999247_2 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000008845 117.0
PYH2_k127_4999247_3 SdrD B-like domain - - - 0.000000000000002834 87.0
PYH2_k127_5056987_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 371.0
PYH2_k127_5056987_1 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000002643 220.0
PYH2_k127_5056987_2 snRNP Sm proteins K04796 GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000002666 90.0
PYH2_k127_5056987_3 Ribosomal protein L37e K02922 - - 0.00000000000000001188 83.0
PYH2_k127_5060673_0 Fibronectin type III domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004442 311.0
PYH2_k127_5060673_1 - - - - 0.00000000000000000000000000000000000000000000000000001241 214.0
PYH2_k127_5060673_2 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000001485 175.0
PYH2_k127_5060673_3 DnaB-like helicase C terminal domain - - - 0.0000000000000000000000000000000000007354 147.0
PYH2_k127_5060673_4 Cna B domain protein - - - 0.00000000000000000000000000626 128.0
PYH2_k127_5060673_5 CarboxypepD_reg-like domain K13276 - - 0.00000000000000000000000005293 127.0
PYH2_k127_5060673_6 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 0.00000007708 67.0
PYH2_k127_5060673_7 Protein of unknown function (DUF835) - - - 0.000000503 63.0
PYH2_k127_5060673_8 Tetratricopeptide repeat - - - 0.00007262 55.0
PYH2_k127_5060673_9 domain, Protein - - - 0.0003788 54.0
PYH2_k127_5064470_0 cysteinyl-tRNA synthetase K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 451.0
PYH2_k127_5064470_1 cystathionine K01739,K01758,K01760 - 2.5.1.48,4.4.1.1,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 426.0
PYH2_k127_5064470_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 323.0
PYH2_k127_5064470_3 - - - - 0.0000000000000000000000000000000000005194 150.0
PYH2_k127_5064470_4 transcriptional regulators - - - 0.000000000000000004819 95.0
PYH2_k127_5064470_5 MFS_1 like family - - - 0.0000001179 64.0
PYH2_k127_5074138_0 metal-binding domain in RNase L inhibitor, RLI K06174 GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 7.385e-235 741.0
PYH2_k127_5074138_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 2.623e-198 644.0
PYH2_k127_5074138_10 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000007353 234.0
PYH2_k127_5074138_11 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000005917 214.0
PYH2_k127_5074138_12 Contacts the emerging nascent chain on the ribosome K03626 - - 0.00000000000000000000001212 104.0
PYH2_k127_5074138_13 Belongs to the UPF0248 family K09715 - - 0.00000000000000004201 83.0
PYH2_k127_5074138_14 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000001245 66.0
PYH2_k127_5074138_15 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000002794 76.0
PYH2_k127_5074138_2 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007862 361.0
PYH2_k127_5074138_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 353.0
PYH2_k127_5074138_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 353.0
PYH2_k127_5074138_5 ATP-grasp domain K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 339.0
PYH2_k127_5074138_6 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 331.0
PYH2_k127_5074138_7 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01464,K01465,K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.2,3.5.2.3,3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 320.0
PYH2_k127_5074138_8 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000005023 244.0
PYH2_k127_5074138_9 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000005233 243.0
PYH2_k127_50777_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 392.0
PYH2_k127_50777_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 326.0
PYH2_k127_50777_2 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000004697 130.0
PYH2_k127_512067_0 Enoyl-CoA hydratase/isomerase - - - 3.226e-198 638.0
PYH2_k127_512067_1 Enoyl-CoA hydratase isomerase K07539 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 590.0
PYH2_k127_512067_2 Belongs to the thiolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 457.0
PYH2_k127_512067_3 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 372.0
PYH2_k127_512067_4 Enoyl-CoA hydratase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000007584 273.0
PYH2_k127_512067_5 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.00000000000000000000000000000000005902 149.0
PYH2_k127_512067_6 Putative small multi-drug export protein - - - 0.0000000000000001057 85.0
PYH2_k127_5169552_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0 1611.0
PYH2_k127_5169552_1 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004911 528.0
PYH2_k127_5169552_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 356.0
PYH2_k127_5169552_3 Fibronectin type 3 domain K12685,K16785,K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000003131 240.0
PYH2_k127_5169552_4 Ribbon-helix-helix protein, copG family K07722 - - 0.00000000000000001962 90.0
PYH2_k127_5169552_5 Membrane - - - 0.000000000000003725 85.0
PYH2_k127_5169552_6 Protein of unknown function (DUF1349) - - - 0.00000002124 68.0
PYH2_k127_519779_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006018 280.0
PYH2_k127_519779_1 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000004085 255.0
PYH2_k127_519779_2 Regulatory protein Crp K07730 - - 0.00000000000000000000000000000000356 145.0
PYH2_k127_519779_3 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000001207 74.0
PYH2_k127_5216074_0 GMP synthase C terminal domain K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 446.0
PYH2_k127_5216074_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 452.0
PYH2_k127_5216074_10 extracellular matrix structural constituent K02035 - - 0.0001873 51.0
PYH2_k127_5216074_2 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 411.0
PYH2_k127_5216074_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 394.0
PYH2_k127_5216074_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000001324 233.0
PYH2_k127_5216074_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000003597 133.0
PYH2_k127_5216074_6 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000003392 121.0
PYH2_k127_5216074_7 - - - - 0.0000000000000000000000000002817 119.0
PYH2_k127_5216074_8 - - - - 0.0000000000000000000000000007974 121.0
PYH2_k127_5216074_9 Protein of unknown function DUF72 - - - 0.000000000000000001626 94.0
PYH2_k127_5234766_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 331.0
PYH2_k127_5234766_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000001858 235.0
PYH2_k127_5234766_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088,K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000001484 213.0
PYH2_k127_5234766_3 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000001161 141.0
PYH2_k127_5234766_4 but it may be involved in stabilization of the trimeric complex - - - 0.00000006157 55.0
PYH2_k127_5280517_0 Clostripain family - - - 0.0000000000000000000000000000000000000000000000000000006908 202.0
PYH2_k127_5280517_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000001122 168.0
PYH2_k127_5280517_2 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000007344 101.0
PYH2_k127_5293514_0 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002128 291.0
PYH2_k127_5293514_1 SMART ATPase, AAA type, core K01990 - - 0.0000000000000000000000000000000000006169 141.0
PYH2_k127_5293514_2 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 0.00000002049 64.0
PYH2_k127_5319835_0 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 293.0
PYH2_k127_5319835_1 PFAM GvpD gas vesicle - - - 0.00000000000000000000000000000000000000000000000000008342 204.0
PYH2_k127_5319835_2 Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c - GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.000000000004123 76.0
PYH2_k127_5319835_3 Vitamin k epoxide reductase - - - 0.00000000006862 70.0
PYH2_k127_5326942_0 endonuclease III K07457 - - 0.0000000000000000000000000000000000000000000000000000000000000002843 227.0
PYH2_k127_5326942_1 cog cog1373 K07133 - - 0.00000000000000000000000000000000000000000852 170.0
PYH2_k127_5326942_2 COG0671 Membrane-associated phospholipid phosphatase K19302 - 3.6.1.27 0.00000000000002858 81.0
PYH2_k127_5326942_3 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate K00756 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2 0.000006164 56.0
PYH2_k127_5394650_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.321e-224 707.0
PYH2_k127_5394650_1 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 594.0
PYH2_k127_5394650_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 479.0
PYH2_k127_5394650_3 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 294.0
PYH2_k127_5394650_4 PP-loop family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003355 267.0
PYH2_k127_5394650_5 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000003594 164.0
PYH2_k127_5394650_6 MaoC like domain K17865 - 4.2.1.55 0.000000002091 60.0
PYH2_k127_5446098_0 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 410.0
PYH2_k127_5446098_1 FAD dependent oxidoreductase K00313 - - 0.0000000000000000000000000000000000000000000000000000000000000177 223.0
PYH2_k127_5446098_2 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000001661 167.0
PYH2_k127_5456856_0 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000002915 209.0
PYH2_k127_5456856_1 KaiC - - - 0.00000000000000000000000000000004775 141.0
PYH2_k127_5512332_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 492.0
PYH2_k127_5512332_1 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000402 101.0
PYH2_k127_5512332_2 nucleic acid-binding protein contains PIN domain K07063 - - 0.000000000000000000006928 96.0
PYH2_k127_5512332_3 Helix-turn-helix domain K03627 - - 0.000000000001965 76.0
PYH2_k127_5512332_4 toxin-antitoxin pair type II binding - - - 0.000000313 56.0
PYH2_k127_5564912_0 PFAM Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000334 238.0
PYH2_k127_5636031_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000009578 166.0
PYH2_k127_5636031_1 nitrogen compound transport K02033,K12369 - - 0.000001025 60.0
PYH2_k127_5657344_0 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.0000000000000000000000000000000000000000005723 183.0
PYH2_k127_5657344_1 Belongs to the peptidase S8 family - - - 0.000000000000006846 87.0
PYH2_k127_5657344_2 solute binding protein K02035 - - 0.00000003002 68.0
PYH2_k127_5659914_0 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000004907 210.0
PYH2_k127_5659914_1 aminopeptidase activity K09612,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.10,3.4.11.24,3.4.11.6 0.0000000002605 72.0
PYH2_k127_5735991_0 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 7.936e-216 684.0
PYH2_k127_5735991_1 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 461.0
PYH2_k127_5735991_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 321.0
PYH2_k127_5735991_3 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 298.0
PYH2_k127_5735991_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000003202 201.0
PYH2_k127_5735991_5 4 iron, 4 sulfur cluster binding K00205,K02573 - - 0.000000000000000000000000000003804 121.0
PYH2_k127_5744749_0 Putative exonuclease SbcCD, C subunit K03546 - - 0.000000000000000001386 96.0
PYH2_k127_5744749_1 PFAM HAS barrel domain K06915 - - 0.00002902 50.0
PYH2_k127_5744749_2 NurA - - - 0.00006006 55.0
PYH2_k127_5750825_0 PFAM Archaeal ATPase K03524,K06921 - 6.3.4.15 0.0000000000000000000000000000000000178 149.0
PYH2_k127_5750825_1 extracellular matrix structural constituent - - - 0.00001511 54.0
PYH2_k127_579372_0 Heat shock 70 kDa protein K04043 - - 1.101e-241 762.0
PYH2_k127_579372_1 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 382.0
PYH2_k127_579372_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003122 245.0
PYH2_k127_579372_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000007354 239.0
PYH2_k127_579372_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000001859 224.0
PYH2_k127_579372_5 amine dehydrogenase activity K20276 - - 0.00000000000000000000000000000000000000000005504 187.0
PYH2_k127_579372_6 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.0000000000000000000000000000000009656 134.0
PYH2_k127_579372_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000002243 126.0
PYH2_k127_579372_8 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000195 86.0
PYH2_k127_579372_9 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.000001509 57.0
PYH2_k127_5846239_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 347.0
PYH2_k127_5846239_1 MMPL family K06994 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 344.0
PYH2_k127_5846239_2 Helix-hairpin-helix motif K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000005687 238.0
PYH2_k127_5846239_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000131 117.0
PYH2_k127_5846239_4 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000001052 112.0
PYH2_k127_5846239_5 DNA-directed RNA polymerase subunit F K03051 - 2.7.7.6 0.00000000000003779 76.0
PYH2_k127_5865547_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005505 270.0
PYH2_k127_5865547_1 TatD related DNase K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001831 262.0
PYH2_k127_5865547_2 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000001715 146.0
PYH2_k127_5865547_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000348 133.0
PYH2_k127_5865547_4 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000001002 121.0
PYH2_k127_5865547_5 conserved protein, contains double-stranded beta-helix domain K00450,K06720 - 1.13.11.4,4.2.1.108 0.00000000000000000005725 92.0
PYH2_k127_5865547_6 Acetyltransferase (GNAT) domain - - - 0.000000000009154 69.0
PYH2_k127_588382_0 D-aminopeptidase K16203 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006045 274.0
PYH2_k127_588382_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002654 277.0
PYH2_k127_588382_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000007815 196.0
PYH2_k127_588382_3 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000001688 149.0
PYH2_k127_588382_4 homolog of PrgY (pheromone shutdown protein) - - - 0.00000000000000000000000000000004699 134.0
PYH2_k127_588382_5 Transcriptional regulator, ArsR family - - - 0.00000000000000000000001855 108.0
PYH2_k127_588382_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000001281 77.0
PYH2_k127_6066535_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000003748 137.0
PYH2_k127_6066535_1 protein conserved in archaea - - - 0.00000000000000000000002576 103.0
PYH2_k127_6066535_2 PFAM Peptidase C1A, papain C-terminal - - - 0.000000002858 71.0
PYH2_k127_6076457_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.314e-266 835.0
PYH2_k127_6076457_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 385.0
PYH2_k127_6076457_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 344.0
PYH2_k127_6076457_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 302.0
PYH2_k127_6076457_4 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000003241 238.0
PYH2_k127_6076457_5 Asparaginase K01424,K13051 - 3.4.19.5,3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000007345 229.0
PYH2_k127_6076457_6 Cytidylyltransferase-like K00952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.1 0.0000000000000000000000000000000000000000000001654 173.0
PYH2_k127_6076457_7 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000000000000000002179 170.0
PYH2_k127_6076457_8 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000008918 153.0
PYH2_k127_6076457_9 protein conserved in archaea - - - 0.0001847 45.0
PYH2_k127_6083219_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 1.447e-292 915.0
PYH2_k127_6083219_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 575.0
PYH2_k127_6083219_2 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 434.0
PYH2_k127_6083219_3 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000006934 198.0
PYH2_k127_6083219_4 Subtilase family - - - 0.00000000000000000000000000000000000000002754 179.0
PYH2_k127_6083219_5 transcription regulator activity - - - 0.000000000000000000000000000000000000005497 152.0
PYH2_k127_6083219_6 COG1994 Zn-dependent proteases - - - 0.00000000000000000000000000000001559 135.0
PYH2_k127_6083219_7 Membrane protein implicated in regulation of membrane protease activity - - - 0.0000000000000000000000000001235 121.0
PYH2_k127_6083219_8 PRC-barrel domain - - - 0.000000000000000000000006439 103.0
PYH2_k127_6083219_9 intracellular protein transport K05989 - 3.2.1.40 0.000000000002407 83.0
PYH2_k127_6096981_0 Belongs to the carbamoyltransferase HypF family K04656 - - 1.275e-237 757.0
PYH2_k127_6096981_1 hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 332.0
PYH2_k127_6096981_2 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 323.0
PYH2_k127_6096981_3 Periplasmic copper-binding protein (NosD) - - - 0.00000000000001875 88.0
PYH2_k127_6096981_4 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000001737 74.0
PYH2_k127_6096981_5 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.000000000008435 70.0
PYH2_k127_6096981_6 Acetyltransferase (GNAT) domain - - - 0.0000000009404 66.0
PYH2_k127_6261845_0 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 438.0
PYH2_k127_6261845_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 471.0
PYH2_k127_6261845_10 - - - - 0.00002283 49.0
PYH2_k127_6261845_2 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 385.0
PYH2_k127_6261845_3 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 371.0
PYH2_k127_6261845_4 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000123 287.0
PYH2_k127_6261845_5 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000004043 136.0
PYH2_k127_6261845_6 Signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000005264 145.0
PYH2_k127_6261845_7 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.000000000000000297 89.0
PYH2_k127_6261845_8 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000298 79.0
PYH2_k127_6261845_9 PFAM plasmid stabilization system K06218 - - 0.00000000001872 67.0
PYH2_k127_6352730_0 PFAM Aspartate glutamate uridylate kinase K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 308.0
PYH2_k127_6352730_1 TIGRFAM small GTP-binding protein K06944 - - 0.0003912 43.0
PYH2_k127_6366705_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 549.0
PYH2_k127_6366705_1 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 496.0
PYH2_k127_6366705_2 tRNA intron endonuclease, catalytic C-terminal domain K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.000000000000000000000000007313 112.0
PYH2_k127_6366705_3 Double zinc ribbon - - - 0.000000000009586 74.0
PYH2_k127_6366705_4 RNA-binding protein involved in rRNA processing K07569 - - 0.000003982 53.0
PYH2_k127_6391029_0 Papain family cysteine protease - - - 0.00000000000000000000007664 116.0
PYH2_k127_6391029_1 Subtilase family - - - 0.000004494 61.0
PYH2_k127_6421920_0 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000001284 154.0
PYH2_k127_6421920_1 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000006111 155.0
PYH2_k127_6421920_2 - - - - 0.00000001285 59.0
PYH2_k127_6485086_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 3.508e-234 743.0
PYH2_k127_6485086_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 513.0
PYH2_k127_6485086_2 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007799 264.0
PYH2_k127_6485086_3 Tubulin like - - - 0.0005888 47.0
PYH2_k127_6544964_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 506.0
PYH2_k127_6544964_1 Belongs to the carbohydrate kinase PfkB family K22026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008906,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000001229 200.0
PYH2_k127_6544964_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000007272 124.0
PYH2_k127_6544964_3 FR47-like protein - - - 0.000000000001732 76.0
PYH2_k127_6544964_4 Bacterial PH domain K08981 - - 0.0000007594 58.0
PYH2_k127_6544964_5 - - - - 0.00004519 48.0
PYH2_k127_661076_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.525e-206 671.0
PYH2_k127_661076_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 483.0
PYH2_k127_661076_2 TIGRFAM iron-sulfur cluster binding protein K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000008589 224.0
PYH2_k127_661076_3 Periplasmic copper-binding protein (NosD) - - - 0.000000000006463 78.0
PYH2_k127_661076_4 - - - - 0.000000008143 64.0
PYH2_k127_6612143_0 4-hydroxy-tetrahydrodipicolinate reductase K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 430.0
PYH2_k127_6612143_1 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions K02201 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000007643 269.0
PYH2_k127_6612143_2 - - - - 0.00000000000000000000000000531 110.0
PYH2_k127_6612143_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000004335 68.0
PYH2_k127_6612143_4 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.00005876 49.0
PYH2_k127_6662654_0 COG1138 Cytochrome c biogenesis factor K02198 - - 0.0000004326 63.0
PYH2_k127_6674778_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044,K13798 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1568.0
PYH2_k127_6674778_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1239.0
PYH2_k127_6674778_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 372.0
PYH2_k127_6674778_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000003486 179.0
PYH2_k127_6674778_4 Participates in transcription termination K02600 - - 0.0000000000000000000000000000000000001542 147.0
PYH2_k127_6674778_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000002361 95.0
PYH2_k127_6674778_6 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000006072 93.0
PYH2_k127_6713151_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 354.0
PYH2_k127_6713151_1 metal-sulfur cluster biosynthetic enzyme - - - 0.00000000000000000000000000000000000009842 143.0
PYH2_k127_6713151_2 Thiopurine S-methyltransferase (TPMT) - - - 0.00000000000000000000000000000254 128.0
PYH2_k127_6713151_3 sulfur carrier activity K00549,K04085,K04487,K08363 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.14,2.8.1.7 0.0000000000000000000007621 99.0
PYH2_k127_6764252_0 UDP binding domain K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008304 334.0
PYH2_k127_6764252_1 Oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 302.0
PYH2_k127_6764252_2 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000009648 157.0
PYH2_k127_6764252_3 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000289 108.0
PYH2_k127_6871506_0 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 340.0
PYH2_k127_6871506_1 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000005792 230.0
PYH2_k127_6871506_2 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.000000000000000000008757 97.0
PYH2_k127_6871506_3 ABC-2 type transporter K01992 - - 0.00000000000000001102 96.0
PYH2_k127_6871506_4 cellulase activity K01183,K01728 - 3.2.1.14,4.2.2.2 0.000000001099 69.0
PYH2_k127_688960_0 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 509.0
PYH2_k127_688960_1 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 452.0
PYH2_k127_688960_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002899 263.0
PYH2_k127_688960_3 - - - - 0.00000000000000000000000000000000000006387 148.0
PYH2_k127_688960_4 phytanoyl-CoA dioxygenase - - - 0.00000000000000000000000000004517 134.0
PYH2_k127_688960_5 Fibronectin type III domain protein - - - 0.00000000000000000000007814 115.0
PYH2_k127_688960_6 EamA-like transporter family - - - 0.0000000000000000000004754 101.0
PYH2_k127_688960_7 - - - - 0.0002575 54.0
PYH2_k127_6901438_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 542.0
PYH2_k127_6901438_1 Beta-Casp domain K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 460.0
PYH2_k127_6901438_10 NADH ubiquinone oxidoreductase subunit 3 (Chain a) K00330,K22158 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016695,GO:0046995,GO:0051911,GO:0055114 1.5.98.3,1.6.5.3 0.0000000000000000001997 94.0
PYH2_k127_6901438_11 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.00000000001104 68.0
PYH2_k127_6901438_12 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.000005767 60.0
PYH2_k127_6901438_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 372.0
PYH2_k127_6901438_3 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 380.0
PYH2_k127_6901438_4 Purine nucleoside phosphorylase involved in purine salvage K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 338.0
PYH2_k127_6901438_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004582 262.0
PYH2_k127_6901438_6 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000003624 240.0
PYH2_k127_6901438_7 ATPase, AAA superfamily - - - 0.00000000000000000000000000000000000000000000000000000009658 216.0
PYH2_k127_6901438_8 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000297 171.0
PYH2_k127_6901438_9 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000005888 160.0
PYH2_k127_6905566_0 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001773 254.0
PYH2_k127_6905566_1 - - - - 0.000000000000000000002927 101.0
PYH2_k127_6905566_2 Domain of unknown function DUF11 - - - 0.0000000005383 74.0
PYH2_k127_6916463_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 392.0
PYH2_k127_6918929_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.272e-217 688.0
PYH2_k127_6918929_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 417.0
PYH2_k127_6918929_10 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000001357 205.0
PYH2_k127_6918929_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000002686 199.0
PYH2_k127_6918929_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000004288 188.0
PYH2_k127_6918929_13 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000005294 178.0
PYH2_k127_6918929_14 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000005656 166.0
PYH2_k127_6918929_15 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000003329 168.0
PYH2_k127_6918929_16 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000902 158.0
PYH2_k127_6918929_17 binds to the 23S rRNA K02885 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000002332 154.0
PYH2_k127_6918929_18 Translation initiation factor SUI1 K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000004668 149.0
PYH2_k127_6918929_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000001004 147.0
PYH2_k127_6918929_2 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 411.0
PYH2_k127_6918929_20 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000003568 138.0
PYH2_k127_6918929_21 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000007182 128.0
PYH2_k127_6918929_22 ribosomal protein L24 K02895 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000004179 108.0
PYH2_k127_6918929_23 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000001105 114.0
PYH2_k127_6918929_24 ribosomal protein S14 K02954 - - 0.0000000000000003341 87.0
PYH2_k127_6918929_25 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000007092 79.0
PYH2_k127_6918929_26 Ribosomal L29 protein K02904 - - 0.000000000001033 79.0
PYH2_k127_6918929_3 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003475 291.0
PYH2_k127_6918929_4 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003651 290.0
PYH2_k127_6918929_5 Ribosomal Proteins L2, C-terminal domain K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002179 271.0
PYH2_k127_6918929_6 Ribosomal family S4e K02987 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000002787 241.0
PYH2_k127_6918929_7 Forms part of the polypeptide exit tunnel K02930 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000008598 243.0
PYH2_k127_6918929_8 Male sterility protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000001498 223.0
PYH2_k127_6918929_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000005917 212.0
PYH2_k127_6942406_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 334.0
PYH2_k127_6942406_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 340.0
PYH2_k127_6942406_10 Integral membrane protein DUF106 - - - 0.00000005536 64.0
PYH2_k127_6942406_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 290.0
PYH2_k127_6942406_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001552 269.0
PYH2_k127_6942406_4 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000007808 241.0
PYH2_k127_6942406_5 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000006875 153.0
PYH2_k127_6942406_6 50S ribosomal protein L37Ae K02921 - - 0.00000000000000000002215 93.0
PYH2_k127_6942406_7 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000001359 84.0
PYH2_k127_6942406_8 DNA directed RNA polymerase, 7 kDa subunit K03059 - 2.7.7.6 0.0000000001623 62.0
PYH2_k127_6942406_9 Transcription factor Pcc1 K09741 - - 0.00000002527 58.0
PYH2_k127_6951126_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000001698 248.0
PYH2_k127_6960289_0 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 2.425e-211 666.0
PYH2_k127_6960289_1 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 449.0
PYH2_k127_6960289_10 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000006502 244.0
PYH2_k127_6960289_11 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000002171 209.0
PYH2_k127_6960289_12 snoRNA binding domain, fibrillarin K14564 GO:0000154,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030515,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000009094 213.0
PYH2_k127_6960289_13 - - - - 0.00000000000000000000000000000000000000000000000000275 190.0
PYH2_k127_6960289_14 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000003821 181.0
PYH2_k127_6960289_15 PFAM metallophosphoesterase K06953 - - 0.000000000000000000000000000000000000000005748 163.0
PYH2_k127_6960289_16 ribosomal protein S15 K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000002686 153.0
PYH2_k127_6960289_17 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000006781 168.0
PYH2_k127_6960289_18 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000005428 156.0
PYH2_k127_6960289_19 metallopeptidase activity K06974 - - 0.000000000000000000000000000001458 126.0
PYH2_k127_6960289_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 419.0
PYH2_k127_6960289_20 Met-10+ like-protein K15429 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000292 117.0
PYH2_k127_6960289_21 SMART PAS domain containing protein - - - 0.0000000000000002498 93.0
PYH2_k127_6960289_22 - - - - 0.000000000000001327 79.0
PYH2_k127_6960289_23 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000005373 87.0
PYH2_k127_6960289_24 Peptidase A24B, FlaK domain protein K07991 - 3.4.23.52 0.000000000002237 78.0
PYH2_k127_6960289_25 PFAM MscS Mechanosensitive ion channel K16052 - - 0.00000000001765 76.0
PYH2_k127_6960289_26 Head domain of trimeric autotransporter adhesin K21449 - - 0.0006068 47.0
PYH2_k127_6960289_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 374.0
PYH2_k127_6960289_4 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 348.0
PYH2_k127_6960289_5 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 353.0
PYH2_k127_6960289_6 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 309.0
PYH2_k127_6960289_7 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 289.0
PYH2_k127_6960289_8 Arginase family K01476,K01480 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006861 272.0
PYH2_k127_6960289_9 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000116 237.0
PYH2_k127_697570_0 KH domain K07041 - - 4.033e-260 815.0
PYH2_k127_697570_1 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000644 262.0
PYH2_k127_697570_10 ThiS family K03154 - - 0.0005723 46.0
PYH2_k127_697570_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003309 256.0
PYH2_k127_697570_3 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001846 261.0
PYH2_k127_697570_4 Phosphoribosyl transferase domain K00769,K07101 - 2.4.2.22 0.0000000000000000000000000000000000000000000000000000000000000000001188 237.0
PYH2_k127_697570_5 4Fe-4S single cluster domain K07129 - - 0.000000000000000000000000000000000000000000000000006447 188.0
PYH2_k127_697570_6 membrane - - - 0.00000000000000000000000000168 118.0
PYH2_k127_697570_7 OB-fold nucleic acid binding domain - - - 0.00000000000000000002577 97.0
PYH2_k127_697570_8 von Willebrand factor, type A K07114 - - 0.00000000000000001592 99.0
PYH2_k127_697570_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000137 91.0
PYH2_k127_7089742_0 CoA binding domain K09181 - - 4.701e-274 866.0
PYH2_k127_7089742_1 PFAM AMP-dependent synthetase and ligase - - - 1.405e-221 700.0
PYH2_k127_7089742_10 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000004536 187.0
PYH2_k127_7089742_11 snRNP Sm proteins K04796 - - 0.000000000000000001117 90.0
PYH2_k127_7089742_12 Molybdopterin converting factor, small subunit K03636,K03750,K07101 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.10.1.1 0.00000000004425 67.0
PYH2_k127_7089742_2 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 605.0
PYH2_k127_7089742_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 458.0
PYH2_k127_7089742_4 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002081 276.0
PYH2_k127_7089742_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.00000000000000000000000000000000000000000000000000000000000000000000001315 272.0
PYH2_k127_7089742_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000005227 252.0
PYH2_k127_7089742_7 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000004335 241.0
PYH2_k127_7089742_8 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000002 200.0
PYH2_k127_7089742_9 MobA-like NTP transferase domain K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000002672 198.0
PYH2_k127_712728_0 PFAM Aminotransferase, class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 303.0
PYH2_k127_712728_1 DnaB-like helicase C terminal domain - - - 0.00000000000000000000009969 106.0
PYH2_k127_712728_2 - - - - 0.00002354 48.0
PYH2_k127_712728_3 Double zinc ribbon - - - 0.0002358 53.0
PYH2_k127_712728_4 COG0477 Permeases of the major facilitator superfamily K08153,K19578 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0003634 47.0
PYH2_k127_7144396_0 PFAM Radical SAM domain protein K22226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 519.0
PYH2_k127_7144396_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 505.0
PYH2_k127_7144396_2 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009213 437.0
PYH2_k127_7144396_3 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 300.0
PYH2_k127_7144396_4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303,K02304 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000378 248.0
PYH2_k127_7144396_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000008486 239.0
PYH2_k127_7144396_6 ABC transporter K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000003909 226.0
PYH2_k127_7144396_7 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000005699 178.0
PYH2_k127_7156407_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001525 244.0
PYH2_k127_7156407_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000001715 232.0
PYH2_k127_7156407_2 Elongator protein 3, MiaB family, Radical SAM K09711 - - 0.000000000000000000000000000000000000000000000000003163 192.0
PYH2_k127_7156407_4 Tetratricopeptide repeat - - - 0.0005378 48.0
PYH2_k127_7174093_0 HELICc2 K03722,K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 510.0
PYH2_k127_7174093_1 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000001623 162.0
PYH2_k127_7174093_2 DnaB-like helicase C terminal domain - - - 0.000000000000000000000000000000000000006143 154.0
PYH2_k127_7197724_0 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002011 289.0
PYH2_k127_7197724_1 - - - - 0.0000000000000000000000000003623 127.0
PYH2_k127_7197724_2 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000001085 64.0
PYH2_k127_7197724_3 Protein of unknown function (DUF559) - - - 0.000002556 55.0
PYH2_k127_7200363_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 460.0
PYH2_k127_7200363_1 COG2998 ABC-type tungstate transport system, permease component - - - 0.00000000000000000000000000000000000000000000000000000000002665 216.0
PYH2_k127_7200363_2 PFAM binding-protein-dependent transport systems inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000462 191.0
PYH2_k127_7200363_3 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000002482 188.0
PYH2_k127_7200363_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000001078 190.0
PYH2_k127_7200363_5 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000001122 54.0
PYH2_k127_7200363_6 Belongs to the thioredoxin family K03671,K03672 - 1.8.1.8 0.0000001154 60.0
PYH2_k127_7228133_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.672e-290 902.0
PYH2_k127_7228133_1 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 466.0
PYH2_k127_7228133_2 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000004539 216.0
PYH2_k127_7228133_3 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000006658 152.0
PYH2_k127_7228133_4 AAA ATPase domain K12132 - 2.7.11.1 0.00000000000000000000000000005953 129.0
PYH2_k127_7228133_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000000769 104.0
PYH2_k127_7228133_6 Domain of unknown function (DUF1610) K07580 - - 0.000000000000004194 79.0
PYH2_k127_7228133_7 - - - - 0.00000000000005592 73.0
PYH2_k127_7228133_8 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000001388 70.0
PYH2_k127_7228133_9 cell adhesion - - - 0.00002636 58.0
PYH2_k127_7263120_0 AAA domain K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 598.0
PYH2_k127_7263120_1 Toprim domain K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 432.0
PYH2_k127_7263120_2 PFAM Thiolase K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000001691 215.0
PYH2_k127_7263120_3 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000006914 177.0
PYH2_k127_7263120_4 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000004068 113.0
PYH2_k127_7263120_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000001149 57.0
PYH2_k127_7325998_0 Staphylococcal nuclease homologue - - - 0.00000000000000000000000000000000000000298 152.0
PYH2_k127_7325998_1 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000003048 117.0
PYH2_k127_7325998_2 PFAM SMC domain protein K03546 - - 0.00000000000008785 85.0
PYH2_k127_7377064_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 514.0
PYH2_k127_7377064_1 ABC transporter K02010,K02017,K02052,K02062,K10112,K11072,K15497,K17240 - 3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 336.0
PYH2_k127_7377064_2 ABC transporter K02010,K02017,K02052,K02062,K10112,K11072,K15497,K17240 - 3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 336.0
PYH2_k127_7377064_3 - - - - 0.0000000000000000000000000000000000000000000000000000003524 204.0
PYH2_k127_7377064_4 Flavin reductase like domain - - - 0.00000000000000000000000000000000002625 140.0
PYH2_k127_7377064_5 Phosphate transport regulator K07220 - - 0.0000000000000000000000000001858 123.0
PYH2_k127_7377064_6 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000002623 94.0
PYH2_k127_7377064_7 PFAM YcfA-like protein - - - 0.00000000000006527 74.0
PYH2_k127_7377064_8 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000005386 65.0
PYH2_k127_7408855_0 M6 family metalloprotease domain protein - - - 0.000000000000005733 89.0
PYH2_k127_7408855_1 COG1404 Subtilisin-like serine proteases K13276 GO:0005575,GO:0005576 - 0.0000006341 63.0
PYH2_k127_7426213_0 Type II/IV secretion system protein K07332 - - 2.381e-221 698.0
PYH2_k127_7426213_1 Type II/IV secretion system protein K07332 - - 6.549e-207 659.0
PYH2_k127_7426213_2 Type II secretion system K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007727 278.0
PYH2_k127_7426213_3 Type II secretion system K07333 - - 0.000000000000000000000000000000000000000000000000000000000000001825 230.0
PYH2_k127_7449263_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 465.0
PYH2_k127_7449263_1 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 301.0
PYH2_k127_7449263_2 Helix-turn-helix XRE-family like proteins K07731 - - 0.000000000000000000000000000000000000000000000000000000000000008966 223.0
PYH2_k127_7545244_0 PUA domain K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000001988 282.0
PYH2_k127_7545244_1 Putative zinc- or iron-chelating domain - - - 0.00000000000000000000000000000000000000000000000000005697 203.0
PYH2_k127_7545244_2 - - - - 0.000000000000000000000006174 104.0
PYH2_k127_7545244_4 - - - - 0.00000098 53.0
PYH2_k127_7569894_0 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 355.0
PYH2_k127_7569894_1 CO dehydrogenase/acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006162 337.0
PYH2_k127_7569894_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000005867 249.0
PYH2_k127_7569894_3 DNA repair and recombination protein RadB K04484 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000003301 206.0
PYH2_k127_7569894_4 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576 2.7.4.26 0.0000000000000000000000000000000000000000000001705 179.0
PYH2_k127_7569894_5 Domain of unknown function (DUF3786) - - - 0.000000000000000000000000000000002095 136.0
PYH2_k127_7599315_0 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.00000000000000000000000000000000000000000000005779 186.0
PYH2_k127_7599315_1 CcmB protein K02194 - - 0.00000000000000000000000003822 113.0
PYH2_k127_7636138_0 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003542 251.0
PYH2_k127_7636138_1 Uncharacterised protein family (UPF0175) - - - 0.0000000000000000000000000000000000000000000000000000000002414 209.0
PYH2_k127_7636138_2 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000006802 156.0
PYH2_k127_7649881_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 572.0
PYH2_k127_7649881_1 PFAM Acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 308.0
PYH2_k127_7649881_2 Possibly the antitoxin component of a - - - 0.000000002229 61.0
PYH2_k127_7649881_3 N-4 methylation of cytosine - - - 0.0000001996 53.0
PYH2_k127_7649881_4 nuclease activity K07062 - - 0.0000004322 59.0
PYH2_k127_7649881_5 Belongs to the ompA family K20276 - - 0.0000928 55.0
PYH2_k127_7651266_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 497.0
PYH2_k127_7651266_1 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 454.0
PYH2_k127_7651266_10 membrane - - - 0.000004051 62.0
PYH2_k127_7651266_11 - - - - 0.0001433 57.0
PYH2_k127_7651266_12 Nuclease, EndA NucM family - - - 0.0001733 57.0
PYH2_k127_7651266_2 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 362.0
PYH2_k127_7651266_3 AAA domain - - - 0.0000000000000000000000000000000000000001924 158.0
PYH2_k127_7651266_4 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000008014 148.0
PYH2_k127_7651266_5 RNA binding K07581 - - 0.00000000000000000000003532 109.0
PYH2_k127_7651266_6 Transcriptional regulator - - - 0.000000000000000000003433 100.0
PYH2_k127_7651266_7 metal ion binding - - - 0.0000000000000000008224 92.0
PYH2_k127_7651266_8 Belongs to the peptidase S8 family K13276,K17734 - - 0.000000001081 74.0
PYH2_k127_7651266_9 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000002828 63.0
PYH2_k127_7651548_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 467.0
PYH2_k127_7651548_1 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000002155 223.0
PYH2_k127_7651548_2 Pyruvoyl-dependent arginine decarboxylase K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000001153 179.0
PYH2_k127_7651548_3 TPR Domain containing protein - - - 0.000000000000000000000000000002979 139.0
PYH2_k127_7651548_4 Transglutaminase-like superfamily - - - 0.00000000000000000000000000004167 132.0
PYH2_k127_7651548_5 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000002198 87.0
PYH2_k127_7651548_6 - - - - 0.0000000000000062 84.0
PYH2_k127_769129_0 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 333.0
PYH2_k127_769129_1 protein conserved in archaea K01733,K02039,K03436,K03524,K03655 - 3.6.4.12,4.2.3.1,6.3.4.15 0.0000000005604 68.0
PYH2_k127_7693275_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 549.0
PYH2_k127_7693275_1 Cysteinyl-tRNA synthetase K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 332.0
PYH2_k127_7693275_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004312 267.0
PYH2_k127_7693275_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000000000000000000000000000000000001641 145.0
PYH2_k127_7710058_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 386.0
PYH2_k127_7710058_1 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000001679 239.0
PYH2_k127_7710058_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000009032 90.0
PYH2_k127_7747401_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 478.0
PYH2_k127_7747401_1 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 349.0
PYH2_k127_7747401_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 348.0
PYH2_k127_7747401_3 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000403 291.0
PYH2_k127_7747401_4 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.00000000003664 64.0
PYH2_k127_7824298_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 319.0
PYH2_k127_7824298_1 Signal peptidase K13280 - 3.4.21.89 0.00000000000000000000004566 106.0
PYH2_k127_7847210_0 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000007099 132.0
PYH2_k127_7847210_1 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000003998 109.0
PYH2_k127_7847210_2 - - - - 0.000000000000000000000004404 113.0
PYH2_k127_7847210_3 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000001025 102.0
PYH2_k127_7847210_4 Sulfatase-modifying factor enzyme 1 K01176,K01206,K01218,K01219,K01224 - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 0.0000000000006546 83.0
PYH2_k127_7847210_5 Protein of unknown function (DUF3494) - - - 0.0000002166 64.0
PYH2_k127_7847210_6 TonB dependent receptor K21573 - - 0.0003738 54.0
PYH2_k127_7874962_0 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 448.0
PYH2_k127_7874962_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 386.0
PYH2_k127_7874962_10 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000889 125.0
PYH2_k127_7874962_11 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000003657 55.0
PYH2_k127_7874962_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 334.0
PYH2_k127_7874962_3 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003041 265.0
PYH2_k127_7874962_4 TIGRFAM TIGR00268 family protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008448 264.0
PYH2_k127_7874962_5 Iron permease FTR1 family K07243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003373 259.0
PYH2_k127_7874962_6 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000581 240.0
PYH2_k127_7874962_7 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000004526 189.0
PYH2_k127_7874962_8 - - - - 0.00000000000000000000000000000000000000000002933 173.0
PYH2_k127_7874962_9 - - - - 0.00000000000000000000000000000000000001519 154.0
PYH2_k127_7894710_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600,K00605,K18847 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 3.121e-295 955.0
PYH2_k127_7894710_1 2Fe-2S iron-sulfur cluster binding domain K00302 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 608.0
PYH2_k127_7894710_2 Sarcosine oxidase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 348.0
PYH2_k127_7894710_3 PFAM ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 302.0
PYH2_k127_7894710_4 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001661 251.0
PYH2_k127_7894710_5 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000001623 226.0
PYH2_k127_7894710_6 4Fe-4S binding domain - - - 0.00000000000000000000000000000000007783 149.0
PYH2_k127_7894710_7 BFD-like [2Fe-2S] binding domain - - - 0.000000000000000000000004297 104.0
PYH2_k127_7894710_8 DHHA1 domain K07463 - - 0.0000000000000000611 81.0
PYH2_k127_7894710_9 Nucleic acid binding - - - 0.0006192 51.0
PYH2_k127_7901771_0 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 532.0
PYH2_k127_7901771_1 Sulfatase-modifying factor enzyme 1 K01176,K01206,K01218,K01219,K01224 - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 0.000000000000484 82.0
PYH2_k127_7904005_0 TIGRFAM oligopeptide dipeptide ABC transporter K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 462.0
PYH2_k127_7904005_1 TIGRFAM oligopeptide dipeptide ABC transporter K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 345.0
PYH2_k127_7904005_10 Methyltransferase type 11 - - - 0.000000000000000000000000000001666 129.0
PYH2_k127_7904005_11 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000143 120.0
PYH2_k127_7904005_2 SMART Elongator protein 3 MiaB NifB K06935,K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 330.0
PYH2_k127_7904005_3 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000546 303.0
PYH2_k127_7904005_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002909 277.0
PYH2_k127_7904005_5 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001588 248.0
PYH2_k127_7904005_6 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000003129 232.0
PYH2_k127_7904005_7 Isochorismatase family K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000001638 195.0
PYH2_k127_7904005_8 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000001823 162.0
PYH2_k127_7904005_9 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000008736 166.0
PYH2_k127_7925375_0 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007543 265.0
PYH2_k127_7925375_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.0000000000000000000000000000000005728 147.0
PYH2_k127_7925375_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000002693 97.0
PYH2_k127_7925375_3 Trm112p-like protein - - - 0.000000000000000000001417 95.0
PYH2_k127_7925375_4 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002373 79.0
PYH2_k127_7952521_0 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 332.0
PYH2_k127_7952521_1 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000003213 123.0
PYH2_k127_7952521_2 TIGRFAM Outer membrane protein K13735,K20276 - - 0.000000006773 70.0
PYH2_k127_7952725_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 325.0
PYH2_k127_7952725_1 to orf3 of fosmid clone 4B7mr3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005476 268.0
PYH2_k127_7952725_2 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000797 197.0
PYH2_k127_7952725_3 Protein of unknown function (DUF1616) - - - 0.00000000000000000000000000000000000000000000001229 182.0
PYH2_k127_7952725_4 ABC-type antimicrobial peptide transport system, permease component - - - 0.0000000000000001875 92.0
PYH2_k127_7952725_5 - - - - 0.000000000000001258 91.0
PYH2_k127_7952725_6 Efflux ABC transporter, permease protein K02004 - - 0.000000303 62.0
PYH2_k127_7952725_7 MacB-like periplasmic core domain K02004 - - 0.00002405 56.0
PYH2_k127_7959489_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 566.0
PYH2_k127_7959489_1 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000008624 260.0
PYH2_k127_7959489_2 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000024 162.0
PYH2_k127_7959489_3 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000002645 63.0
PYH2_k127_7959489_4 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000001716 68.0
PYH2_k127_8001219_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 414.0
PYH2_k127_8001219_1 DeoC/LacD family aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 397.0
PYH2_k127_8001219_2 PFAM GAF domain K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000005429 174.0
PYH2_k127_8001219_3 Thioredoxin K03671 - - 0.0000000000000000000000000000002278 127.0
PYH2_k127_8001219_4 PFAM NHL repeat containing protein - - - 0.0000000000000000004919 103.0
PYH2_k127_8001219_5 Protein of unknown function (DUF835) - - - 0.00000004055 62.0
PYH2_k127_8001219_6 TIGRFAM RHS repeat-associated core domain - - - 0.00000455 60.0
PYH2_k127_8001219_7 transcriptional regulators - - - 0.0007066 46.0
PYH2_k127_802529_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 1.551e-217 693.0
PYH2_k127_8026729_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 1.343e-239 754.0
PYH2_k127_8026729_1 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 398.0
PYH2_k127_8026729_2 GTPase activity K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 289.0
PYH2_k127_8026729_3 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000000000000000000003231 224.0
PYH2_k127_8026729_4 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000032 184.0
PYH2_k127_8026729_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000000000000001313 156.0
PYH2_k127_8026729_6 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000341 94.0
PYH2_k127_8026729_7 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000002329 60.0
PYH2_k127_8055266_0 DNA polymerase type-B family K02319 - 2.7.7.7 3.05e-264 836.0
PYH2_k127_8055266_1 Domain of unknown function DUF11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 636.0
PYH2_k127_8055266_2 GTPase of unknown function C-terminal K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 451.0
PYH2_k127_8055266_3 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000002001 235.0
PYH2_k127_8055266_4 Tetratricopeptide TPR_2 repeat protein K06877 - - 0.000000000000000000000000003252 130.0
PYH2_k127_8060946_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 545.0
PYH2_k127_8060946_1 Psort location Cytoplasmic, score 7.50 - - - 0.0000000002666 70.0
PYH2_k127_8077974_0 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009491 271.0
PYH2_k127_8077974_1 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000002442 200.0
PYH2_k127_8091034_0 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 346.0
PYH2_k127_8091034_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004054 260.0
PYH2_k127_8091034_2 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000004784 223.0
PYH2_k127_8091034_3 ATPase (AAA superfamily K07133 - - 0.000000000000000000000000000000000000000000008949 179.0
PYH2_k127_8091034_4 transposition, DNA-mediated - - - 0.000000000000000000000000001465 117.0
PYH2_k127_8091034_5 Fibronectin type III domain - - - 0.000000000000000172 96.0
PYH2_k127_8091034_6 Type II/IV secretion system protein K07332 - - 0.0000000000000004094 89.0
PYH2_k127_8091034_7 ig-like, plexins, transcription factors - - - 0.00000000000001841 89.0
PYH2_k127_8091034_8 - - - - 0.00000008896 67.0
PYH2_k127_8091034_9 40-residue YVTN family beta-propeller repeat - - - 0.00004942 58.0
PYH2_k127_8095325_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 397.0
PYH2_k127_8095325_1 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000001737 185.0
PYH2_k127_8095325_2 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000003302 177.0
PYH2_k127_8095325_3 Protein of unknown function (DUF3494) - - - 0.0000000000000000000000000000000000521 157.0
PYH2_k127_8095325_4 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000003528 141.0
PYH2_k127_8095325_5 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.000001771 60.0
PYH2_k127_8095325_6 Carboxypeptidase regulatory-like domain - - - 0.000006955 58.0
PYH2_k127_8110234_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 610.0
PYH2_k127_8110234_1 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 441.0
PYH2_k127_8110234_2 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 405.0
PYH2_k127_8110234_3 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005552 251.0
PYH2_k127_8110234_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000005621 218.0
PYH2_k127_8110234_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000002756 226.0
PYH2_k127_8110234_6 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000003259 193.0
PYH2_k127_8110234_7 GDP-mannose 4,6 dehydratase - - - 0.0000000000000000000000000000000000174 145.0
PYH2_k127_8110234_8 PFAM GGDEF domain containing protein - - - 0.0003865 49.0
PYH2_k127_8123730_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006873 326.0
PYH2_k127_8123730_1 bacterioferritin comigratory protein K03564 - 1.11.1.15 0.000000000000000000000000000000000001069 144.0
PYH2_k127_8123730_2 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000003767 68.0
PYH2_k127_8180971_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 448.0
PYH2_k127_8180971_1 Radical SAM K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 385.0
PYH2_k127_8180971_2 Domain of unknown function (DUF4438) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 362.0
PYH2_k127_8180971_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000002109 229.0
PYH2_k127_8180971_4 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000001918 201.0
PYH2_k127_8180971_5 PP-loop family K21947 - 2.8.1.15 0.0000000000000000000000000000001002 127.0
PYH2_k127_8180971_6 TPR Domain containing protein - - - 0.000000000000000641 94.0
PYH2_k127_8204941_0 Flavodoxin - - - 0.000000000000000000000000000007418 129.0
PYH2_k127_8204941_1 AsnC family - - - 0.0007664 51.0
PYH2_k127_821360_0 NADH dehydrogenase K00335 - 1.6.5.3 3.48e-232 740.0
PYH2_k127_821360_1 PFAM formate-tetrahydrofolate ligase FTHFS K01938 - 6.3.4.3 2.231e-228 717.0
PYH2_k127_821360_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 370.0
PYH2_k127_821360_3 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000001481 166.0
PYH2_k127_821360_4 Iron hydrogenase small subunit K00336 - 1.6.5.3 0.0007204 44.0
PYH2_k127_8262542_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 400.0
PYH2_k127_8262542_1 - - - - 0.00000000006166 65.0
PYH2_k127_8331847_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336,K05299 - 1.17.1.10,1.6.5.3 1.608e-241 760.0
PYH2_k127_8331847_1 CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - 3.668e-241 794.0
PYH2_k127_8331847_2 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 4.037e-205 688.0
PYH2_k127_8331847_3 CO dehydrogenase acetyl-CoA synthase K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004555 297.0
PYH2_k127_8331847_4 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000009991 183.0
PYH2_k127_8331847_5 CO dehydrogenase/acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000006065 139.0
PYH2_k127_8331847_6 4Fe-4S dicluster domain - - - 0.000000000000000000000000000002555 124.0
PYH2_k127_8331847_7 Predicted RNA-binding protein - - - 0.00001242 49.0
PYH2_k127_8344612_0 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000004217 180.0
PYH2_k127_8344612_1 PFAM membrane-flanked domain - - - 0.000000001102 68.0
PYH2_k127_8350758_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 2.151e-241 766.0
PYH2_k127_8350758_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009846 387.0
PYH2_k127_8350758_2 6,7-dimethyl-8-ribityllumazine synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000009433 243.0
PYH2_k127_8350758_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000001954 244.0
PYH2_k127_8350758_4 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000001377 213.0
PYH2_k127_8350758_5 DNA polymerase alpha chain like domain - - - 0.00000000000000000000000000000000000000000000000008978 184.0
PYH2_k127_8350758_6 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.00000000000000000000000000000000000000000000001013 175.0
PYH2_k127_8350758_7 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000002105 174.0
PYH2_k127_8350758_8 Roadblock LC7 family protein K07131 - - 0.000000001653 64.0
PYH2_k127_8350758_9 PIN domain - - - 0.0000005596 56.0
PYH2_k127_835151_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 4.487e-252 789.0
PYH2_k127_835151_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.772e-232 731.0
PYH2_k127_835151_2 phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 458.0
PYH2_k127_835151_3 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 331.0
PYH2_k127_835151_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000006615 247.0
PYH2_k127_835151_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000000000000005898 101.0
PYH2_k127_835151_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000002729 95.0
PYH2_k127_835151_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000001682 68.0
PYH2_k127_835151_8 ATP synthase subunit C K02124 - - 0.000000001351 61.0
PYH2_k127_835151_9 TIGRFAM ATP synthase K02107 - - 0.0004734 47.0
PYH2_k127_8384965_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 8.534e-200 632.0
PYH2_k127_8384965_1 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 365.0
PYH2_k127_8384965_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 310.0
PYH2_k127_8384965_3 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000001575 237.0
PYH2_k127_8384965_4 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000005957 211.0
PYH2_k127_8384965_5 - - - - 0.000000000000000000000000000000000000000009012 155.0
PYH2_k127_8384965_6 KR domain - - - 0.0000000007165 60.0
PYH2_k127_843944_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009926 307.0
PYH2_k127_843944_1 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001729 256.0
PYH2_k127_843944_2 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000008537 214.0
PYH2_k127_843944_3 Probable molybdopterin binding domain K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000001058 177.0
PYH2_k127_843944_4 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000003581 175.0
PYH2_k127_843944_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000897 165.0
PYH2_k127_843944_6 PFAM molybdopterin biosynthesis MoaE K03635 - 2.8.1.12 0.0000000000000000000000000000008066 128.0
PYH2_k127_843944_7 4Fe-4S ferredoxin iron-sulfur binding domain protein K21834 - - 0.000000000000000000000000000144 124.0
PYH2_k127_8451808_0 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 297.0
PYH2_k127_8451808_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000005888 239.0
PYH2_k127_8451808_2 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000006521 200.0
PYH2_k127_8451808_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000118 198.0
PYH2_k127_8451808_4 Subtilase family K17734 - - 0.0000000000000000000000000000000000000000000000000002725 214.0
PYH2_k127_8451808_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000852 144.0
PYH2_k127_8451808_6 Papain family cysteine protease - - - 0.000000000000000000000002447 120.0
PYH2_k127_8451808_7 toxin activity - - - 0.000000007425 61.0
PYH2_k127_8451808_8 - - - - 0.00000002263 57.0
PYH2_k127_8451808_9 extracellular matrix structural constituent K02035 - - 0.0008357 54.0
PYH2_k127_851441_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 308.0
PYH2_k127_851441_1 DnaB-like helicase C terminal domain - - - 0.000000000000000000000000000000000106 142.0
PYH2_k127_8522591_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.902e-245 769.0
PYH2_k127_8522591_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 473.0
PYH2_k127_8522591_10 Methyltransferase - - - 0.000000005152 68.0
PYH2_k127_8522591_11 - K07341 - - 0.00000033 57.0
PYH2_k127_8522591_12 - - - - 0.0000004443 56.0
PYH2_k127_8522591_2 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 359.0
PYH2_k127_8522591_3 CobB/CobQ-like glutamine amidotransferase domain K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003207 262.0
PYH2_k127_8522591_4 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000006674 221.0
PYH2_k127_8522591_5 Bacterial regulatory helix-turn-helix protein, lysR family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000001184 199.0
PYH2_k127_8522591_6 cyclohydrolase K01746 - 4.3.1.4 0.00000000000000000000000000000000000000000007615 169.0
PYH2_k127_8522591_7 Fcf1 K07158 - - 0.000000000000000001922 89.0
PYH2_k127_8522591_8 Lrp/AsnC ligand binding domain - - - 0.000000000003382 69.0
PYH2_k127_8522591_9 Belongs to the 4-oxalocrotonate tautomerase family K01821 - 5.3.2.6 0.0000000008558 61.0
PYH2_k127_8536859_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.44e-218 710.0
PYH2_k127_8536859_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 580.0
PYH2_k127_8536859_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 302.0
PYH2_k127_8536859_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000003606 181.0
PYH2_k127_8536859_4 response to antibiotic - - - 0.0004212 52.0
PYH2_k127_8544456_0 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 8.958e-279 934.0
PYH2_k127_8544456_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 426.0
PYH2_k127_8544456_11 RNA-binding protein of the translin family K07477 - - 0.0000000000000000000000000000000000000002763 157.0
PYH2_k127_8544456_12 PFAM CBS domain containing protein - - - 0.000000000000000000000000009787 117.0
PYH2_k127_8544456_13 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000005151 100.0
PYH2_k127_8544456_14 - - - - 0.0000000000000000008849 89.0
PYH2_k127_8544456_15 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000002249 84.0
PYH2_k127_8544456_16 CARDB - - - 0.0000000000000001597 93.0
PYH2_k127_8544456_17 PFAM 4-vinyl reductase, 4VR K07013 - - 0.000000000000009838 84.0
PYH2_k127_8544456_19 Serine threonine protein kinase - - - 0.0000000002613 73.0
PYH2_k127_8544456_2 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 366.0
PYH2_k127_8544456_20 protein conserved in archaea - - - 0.0002902 51.0
PYH2_k127_8544456_3 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 321.0
PYH2_k127_8544456_4 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002867 282.0
PYH2_k127_8544456_5 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000001386 259.0
PYH2_k127_8544456_6 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004105 259.0
PYH2_k127_8544456_8 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001114 235.0
PYH2_k127_8544456_9 Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000428 219.0
PYH2_k127_8547647_0 DnaB-like helicase C terminal domain - - - 0.000000000000000000000000000000000000000000000000000002879 199.0
PYH2_k127_8547647_1 May be involved in maturation of the 30S ribosomal subunit K02966 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000000006271 181.0
PYH2_k127_8547647_2 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000008286 184.0
PYH2_k127_8547647_4 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000002138 158.0
PYH2_k127_8547647_5 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000003116 108.0
PYH2_k127_8547647_6 Aminotransferase - - - 0.00000000000000000000002387 102.0
PYH2_k127_8547647_7 Belongs to the ribosomal protein L31e family K02910 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000006529 95.0
PYH2_k127_8547647_8 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000001444 77.0
PYH2_k127_8547647_9 Belongs to the UPF0216 family K09737 - - 0.0000000696 59.0
PYH2_k127_8567157_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 357.0
PYH2_k127_8567157_1 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000001208 180.0
PYH2_k127_8567157_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000007221 142.0
PYH2_k127_8571307_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006726 311.0
PYH2_k127_8571307_1 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009335 267.0
PYH2_k127_8571307_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003855 264.0
PYH2_k127_8571307_3 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000003122 156.0
PYH2_k127_8571307_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.000946 44.0
PYH2_k127_8571851_0 PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 392.0
PYH2_k127_8571851_1 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000003792 178.0
PYH2_k127_8571851_2 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000003141 121.0
PYH2_k127_8571851_3 Tetratricopeptide repeat - - - 0.0000000000000000006973 97.0
PYH2_k127_8571851_4 Tetratricopeptide repeat domain 28 - - - 0.0000000003549 73.0
PYH2_k127_8571851_5 Transcriptional regulators - - - 0.000000001507 63.0
PYH2_k127_8571851_6 Sulfotransferase domain - - - 0.000417 49.0
PYH2_k127_8574995_0 Pfam:DUF650 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009006 409.0
PYH2_k127_8574995_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000001024 238.0
PYH2_k127_8574995_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000006854 201.0
PYH2_k127_8574995_3 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000000008364 143.0
PYH2_k127_8574995_4 - - - - 0.00000004475 55.0
PYH2_k127_8656920_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 442.0
PYH2_k127_8656920_1 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007802 242.0
PYH2_k127_8656920_2 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000005266 233.0
PYH2_k127_8656920_3 - - - - 0.0000000003422 70.0
PYH2_k127_8660419_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007699 415.0
PYH2_k127_8660419_1 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.0000000000000000000000001229 112.0
PYH2_k127_8660419_2 virion core protein (lumpy skin disease virus) - - - 0.00000074 61.0
PYH2_k127_8716245_0 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB - - - 0.0000000000000000000000000000000000000000000000000007001 199.0
PYH2_k127_8716245_1 4Fe-4S binding domain - - - 0.000000000000000000000000000009927 130.0
PYH2_k127_8782383_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1077.0
PYH2_k127_8833768_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.373e-290 921.0
PYH2_k127_8833768_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000005043 249.0
PYH2_k127_8833768_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000003228 234.0
PYH2_k127_885534_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000001284 189.0
PYH2_k127_885534_1 ubiquitin-conjugating enzyme K10573 - 2.3.2.23 0.00000005281 63.0
PYH2_k127_8873904_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 301.0
PYH2_k127_8873904_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000002207 264.0
PYH2_k127_8873904_2 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000000000000000000002791 246.0
PYH2_k127_8873904_3 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.000000000000000000000000000000000000000000000000000000000004505 216.0
PYH2_k127_8873904_4 UbiA prenyltransferase family K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000002854 214.0
PYH2_k127_8873904_5 PFAM zinc iron permease K16267 - - 0.0000000000000000000000000000000000000000000000000000000002869 211.0
PYH2_k127_8873904_6 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000001239 207.0
PYH2_k127_8873904_7 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000001795 154.0
PYH2_k127_8873904_8 Proprotein convertase P-domain - - - 0.000000001592 66.0
PYH2_k127_8876249_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 441.0
PYH2_k127_8876249_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000001192 217.0
PYH2_k127_8876249_2 - - - - 0.0000000009831 69.0
PYH2_k127_8891225_0 abc transporter atp-binding protein K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 361.0
PYH2_k127_8891225_1 COG0003 Oxyanion-translocating ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000001396 260.0
PYH2_k127_8891225_2 Arsenical resistance operon trans-acting repressor ArsD - - - 0.000000000000000000000002822 106.0
PYH2_k127_8891225_3 PFAM regulatory protein, ArsR K21903 - - 0.0000000000000000002554 91.0
PYH2_k127_8891225_4 Domain of unknown function (DUF4143) K07133 - - 0.000000000000000001158 95.0
PYH2_k127_8891225_5 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0001167 48.0
PYH2_k127_8902309_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1019.0
PYH2_k127_8902309_1 Aldolase/RraA K13831 - 4.1.2.43,5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 531.0
PYH2_k127_8902309_10 Beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000005599 224.0
PYH2_k127_8902309_11 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000009876 202.0
PYH2_k127_8902309_12 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000006465 179.0
PYH2_k127_8902309_13 Membrane - - - 0.0000000000000000000000000000000000000000008544 167.0
PYH2_k127_8902309_14 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000006983 157.0
PYH2_k127_8902309_15 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000000000000009582 115.0
PYH2_k127_8902309_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000001909 84.0
PYH2_k127_8902309_17 von Willebrand factor, type A K07114 - - 0.00000000000004105 88.0
PYH2_k127_8902309_18 Parallel beta-helix repeats - - - 0.0000000000004618 83.0
PYH2_k127_8902309_19 Pfam:DUF1628 - - - 0.0000000000006624 74.0
PYH2_k127_8902309_2 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 539.0
PYH2_k127_8902309_20 - - - - 0.000000000001161 73.0
PYH2_k127_8902309_22 Pfam:DUF1628 - - - 0.00002139 53.0
PYH2_k127_8902309_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 376.0
PYH2_k127_8902309_4 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 347.0
PYH2_k127_8902309_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 325.0
PYH2_k127_8902309_6 Fibronectin type III domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 332.0
PYH2_k127_8902309_7 Rad51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000048 276.0
PYH2_k127_8902309_8 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000184 275.0
PYH2_k127_8902309_9 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000001003 219.0
PYH2_k127_8929952_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 5e-323 1008.0
PYH2_k127_8929952_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000001287 119.0
PYH2_k127_9040525_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 327.0
PYH2_k127_9040525_1 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000002119 168.0
PYH2_k127_9040525_2 Thioredoxin - - - 0.00000000000000000000005309 104.0
PYH2_k127_9040525_3 PKD domain K09607,K19668 - 3.2.1.91 0.00000000002457 76.0
PYH2_k127_9040525_4 Acetyltransferase GNAT Family - - - 0.0000000009168 66.0
PYH2_k127_9047405_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 2.733e-287 904.0
PYH2_k127_9047405_1 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 589.0
PYH2_k127_9047405_2 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002282 280.0
PYH2_k127_9047405_3 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001744 278.0
PYH2_k127_9047405_4 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000003041 183.0
PYH2_k127_9047405_5 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000003534 165.0
PYH2_k127_9047405_6 - - - - 0.000000000000001345 84.0
PYH2_k127_9047405_7 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388,K16885,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000003088 57.0
PYH2_k127_9047405_8 AsnC family - - - 0.0002068 53.0
PYH2_k127_9167223_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 1.25e-259 812.0
PYH2_k127_9167223_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006303 274.0
PYH2_k127_9167223_2 nitroreductase - - - 0.00000000000000000000000000000000000000000000000000003541 196.0
PYH2_k127_9167223_3 Seven times multi-haem cytochrome CxxCH - - - 0.0000000000000000000000000000000000000000000000001141 185.0
PYH2_k127_9167223_4 - - - - 0.000000001181 61.0
PYH2_k127_9167223_5 SpoVT / AbrB like domain - - - 0.0000001802 53.0
PYH2_k127_9201718_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 318.0
PYH2_k127_9201718_1 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.000000000000000000000000000000000000000000000000000000000000000000005194 240.0
PYH2_k127_9201718_2 - - - - 0.00000000000000000000000513 117.0
PYH2_k127_9201718_3 SpoVT / AbrB like domain - - - 0.00000000000000222 81.0
PYH2_k127_9208960_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 314.0
PYH2_k127_9208960_1 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000005212 162.0
PYH2_k127_9252080_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007401 505.0
PYH2_k127_9252080_1 Type II/IV secretion system protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 439.0
PYH2_k127_9252080_10 PFAM Amino acid-binding ACT - - - 0.00000000000000001173 88.0
PYH2_k127_9252080_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001434 302.0
PYH2_k127_9252080_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000288 247.0
PYH2_k127_9252080_4 RIO1 family K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000003698 229.0
PYH2_k127_9252080_5 Protein of unknown function TPD sequence-motif - - - 0.000000000000000000000000000000000000000000000000000000002385 208.0
PYH2_k127_9252080_6 K homology RNA-binding domain K06961 - - 0.00000000000000000000000000000000000000000000000000000007559 200.0
PYH2_k127_9252080_7 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K07575 - - 0.0000000000000000000000000000000000000000000000006201 184.0
PYH2_k127_9252080_8 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000001369 141.0
PYH2_k127_9252080_9 PFAM TPR repeat-containing protein - - - 0.00000000000000000001733 108.0
PYH2_k127_9263432_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 351.0
PYH2_k127_9263432_1 Fe-S cluster K04488 - - 0.0000000000000000000000000000000000000000000000000001086 195.0
PYH2_k127_9263432_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000005951 156.0
PYH2_k127_9263432_3 - - - - 0.00000002573 58.0
PYH2_k127_927152_0 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 3.191e-194 617.0
PYH2_k127_927152_1 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 377.0
PYH2_k127_929382_0 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 325.0
PYH2_k127_929382_1 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB - - - 0.000000000000000000000000000000009319 131.0
PYH2_k127_929382_2 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000002878 131.0
PYH2_k127_929382_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000002646 109.0
PYH2_k127_931177_0 and related - - - 0.000000000000000000000000000000000000000000000000000000000000006469 227.0
PYH2_k127_931177_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000001853 102.0
PYH2_k127_931177_2 PFAM Ribosomal LX protein K02944 - - 0.0000000000704 65.0
PYH2_k127_931177_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00001281 53.0