logo

Overview

ID MAG03189
Name PYH2_bin.39
Sample SMP0074
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species
Assembly information
Completeness (%) 94.94
Contamination (%) 0.16
GC content (%) 55.0
N50 (bp) 43,013
Genome size (bp) 1,567,080

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1626

Gene name Description KEGG GOs EC E-value Score Sequence
PYH2_k127_1065995_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 314.0
PYH2_k127_1065995_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 300.0
PYH2_k127_1065995_10 PFAM GCN5-related N-acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.000000000000000000000000001718 117.0
PYH2_k127_1065995_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000003618 120.0
PYH2_k127_1065995_12 Protein of unknown function (DUF3344) - - - 0.000000000000000000000000003637 127.0
PYH2_k127_1065995_13 Universal stress protein family - - - 0.00000000000000000000000001185 116.0
PYH2_k127_1065995_14 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000005921 90.0
PYH2_k127_1065995_15 metallopeptidase activity - - - 0.000000000000000002485 99.0
PYH2_k127_1065995_2 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002918 261.0
PYH2_k127_1065995_3 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
PYH2_k127_1065995_4 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000000000000000000001078 233.0
PYH2_k127_1065995_5 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000005863 214.0
PYH2_k127_1065995_6 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000008171 186.0
PYH2_k127_1065995_7 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000004114 167.0
PYH2_k127_1065995_8 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000001722 123.0
PYH2_k127_1065995_9 Phosphate-starvation-inducible E - - - 0.0000000000000000000000000006838 117.0
PYH2_k127_1134573_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1019.0
PYH2_k127_1134573_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 7.69e-320 992.0
PYH2_k127_1134573_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 413.0
PYH2_k127_1134573_11 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 351.0
PYH2_k127_1134573_12 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 347.0
PYH2_k127_1134573_13 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 333.0
PYH2_k127_1134573_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 331.0
PYH2_k127_1134573_15 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
PYH2_k127_1134573_16 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000000000000000000000000002806 221.0
PYH2_k127_1134573_17 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000000000000000000000004654 169.0
PYH2_k127_1134573_18 - - - - 0.000000000000000000000000000000000000000003364 163.0
PYH2_k127_1134573_19 protein possibly involved in aromatic compounds catabolism K02614 - - 0.000000000000000000000000000008832 123.0
PYH2_k127_1134573_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.243e-278 859.0
PYH2_k127_1134573_20 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000001282 97.0
PYH2_k127_1134573_21 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000007466 91.0
PYH2_k127_1134573_22 - - - - 0.0000000000000007812 83.0
PYH2_k127_1134573_24 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.0000004548 53.0
PYH2_k127_1134573_3 PFAM chaperonin Cpn60 TCP-1 K22447 - - 3.239e-242 758.0
PYH2_k127_1134573_4 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.635e-226 720.0
PYH2_k127_1134573_5 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 606.0
PYH2_k127_1134573_6 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 595.0
PYH2_k127_1134573_7 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 585.0
PYH2_k127_1134573_8 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 443.0
PYH2_k127_1134573_9 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 427.0
PYH2_k127_1300920_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.224e-285 884.0
PYH2_k127_1300920_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 6.177e-211 665.0
PYH2_k127_1300920_10 - K14093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003181 242.0
PYH2_k127_1300920_11 V4R K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
PYH2_k127_1300920_12 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000001296 212.0
PYH2_k127_1300920_13 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.00000000000000000000000000000000000000000000000000646 185.0
PYH2_k127_1300920_14 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000001358 150.0
PYH2_k127_1300920_15 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000000000000000006185 143.0
PYH2_k127_1300920_16 - K00960 - 2.7.7.6 0.0000000000000000000000000003614 113.0
PYH2_k127_1300920_17 PFAM molydopterin dinucleotide-binding region K00201,K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.0000000000000000000000000006551 117.0
PYH2_k127_1300920_18 Predicted membrane protein (DUF2109) K14094 - - 0.00000000000000000000000000165 115.0
PYH2_k127_1300920_19 - - - - 0.00000000000000000000000001339 108.0
PYH2_k127_1300920_2 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 557.0
PYH2_k127_1300920_20 Predicted membrane protein (DUF2107) K14096 - - 0.0000000000000000000003252 98.0
PYH2_k127_1300920_21 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.00000000000000000003706 96.0
PYH2_k127_1300920_22 Predicted membrane protein (DUF2108) K14095 - - 0.000000000001084 72.0
PYH2_k127_1300920_23 - K14100 - - 0.000000004402 59.0
PYH2_k127_1300920_24 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000002238 53.0
PYH2_k127_1300920_25 - - - - 0.0000002297 59.0
PYH2_k127_1300920_26 - - - - 0.0009765 48.0
PYH2_k127_1300920_3 PFAM Archaeal protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 500.0
PYH2_k127_1300920_4 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 380.0
PYH2_k127_1300920_5 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 374.0
PYH2_k127_1300920_6 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 302.0
PYH2_k127_1300920_7 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
PYH2_k127_1300920_8 4Fe-4S dicluster domain K11260,K14107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004433 257.0
PYH2_k127_1300920_9 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001097 252.0
PYH2_k127_1485102_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1146.0
PYH2_k127_1485102_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.152e-290 900.0
PYH2_k127_1485102_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 355.0
PYH2_k127_1485102_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 336.0
PYH2_k127_1485102_4 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 303.0
PYH2_k127_1485102_5 binding domain, Protein - - - 0.000000000000000000000000000000000000000000000000002383 188.0
PYH2_k127_1485102_6 META domain - - - 0.00000000000000000000000000000000000005876 153.0
PYH2_k127_1485102_7 META domain - - - 0.0000000000000000000000000000000006772 141.0
PYH2_k127_1485102_8 2TM domain - - - 0.00000000000004039 76.0
PYH2_k127_1485102_9 PFAM 4Fe-4S ferredoxin, iron-sulphur binding, subgroup - - - 0.000000000001161 73.0
PYH2_k127_165886_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1602.0
PYH2_k127_165886_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1071.0
PYH2_k127_165886_10 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005835 396.0
PYH2_k127_165886_11 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 359.0
PYH2_k127_165886_12 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 287.0
PYH2_k127_165886_13 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004145 262.0
PYH2_k127_165886_14 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000001447 241.0
PYH2_k127_165886_15 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000002286 233.0
PYH2_k127_165886_16 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000000000002774 231.0
PYH2_k127_165886_17 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000000000000000002849 229.0
PYH2_k127_165886_18 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000000001942 182.0
PYH2_k127_165886_19 COG1403 Restriction endonuclease K10726 - - 0.00000000000000000000000000000000000000000006443 164.0
PYH2_k127_165886_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1047.0
PYH2_k127_165886_20 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000000000000006141 157.0
PYH2_k127_165886_21 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000000000000000001967 136.0
PYH2_k127_165886_22 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000001603 94.0
PYH2_k127_165886_3 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 3.313e-314 965.0
PYH2_k127_165886_4 Conserved region in glutamate synthase - - - 2.345e-294 908.0
PYH2_k127_165886_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 9.958e-205 641.0
PYH2_k127_165886_6 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 533.0
PYH2_k127_165886_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 519.0
PYH2_k127_165886_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 443.0
PYH2_k127_165886_9 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 402.0
PYH2_k127_1793943_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 2.599e-241 754.0
PYH2_k127_1793943_1 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 1.433e-233 751.0
PYH2_k127_1793943_10 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000001374 191.0
PYH2_k127_1793943_11 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000002218 183.0
PYH2_k127_1793943_12 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000001141 132.0
PYH2_k127_1793943_13 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000000000002319 113.0
PYH2_k127_1793943_14 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00000000000000000000000006402 109.0
PYH2_k127_1793943_15 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000000008115 94.0
PYH2_k127_1793943_16 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000007963 83.0
PYH2_k127_1793943_17 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000423 75.0
PYH2_k127_1793943_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 7.985e-215 672.0
PYH2_k127_1793943_3 MviN-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 456.0
PYH2_k127_1793943_4 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 371.0
PYH2_k127_1793943_5 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 318.0
PYH2_k127_1793943_6 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 302.0
PYH2_k127_1793943_7 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008288 244.0
PYH2_k127_1793943_8 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000001543 229.0
PYH2_k127_1793943_9 - - - - 0.000000000000000000000000000000000000000000000000000001339 198.0
PYH2_k127_1931827_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1196.0
PYH2_k127_1931827_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.756e-258 799.0
PYH2_k127_1931827_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 2.571e-194 611.0
PYH2_k127_1931827_11 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 607.0
PYH2_k127_1931827_12 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 610.0
PYH2_k127_1931827_13 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 597.0
PYH2_k127_1931827_14 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 598.0
PYH2_k127_1931827_15 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 597.0
PYH2_k127_1931827_16 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 575.0
PYH2_k127_1931827_17 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 562.0
PYH2_k127_1931827_18 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 556.0
PYH2_k127_1931827_19 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 557.0
PYH2_k127_1931827_2 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 6.453e-244 765.0
PYH2_k127_1931827_20 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008945 539.0
PYH2_k127_1931827_21 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 525.0
PYH2_k127_1931827_22 CoB--CoM heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 520.0
PYH2_k127_1931827_23 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 520.0
PYH2_k127_1931827_24 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 512.0
PYH2_k127_1931827_25 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 494.0
PYH2_k127_1931827_26 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 481.0
PYH2_k127_1931827_27 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 443.0
PYH2_k127_1931827_28 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 444.0
PYH2_k127_1931827_29 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 438.0
PYH2_k127_1931827_3 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.658e-240 745.0
PYH2_k127_1931827_30 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 436.0
PYH2_k127_1931827_31 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 420.0
PYH2_k127_1931827_32 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 414.0
PYH2_k127_1931827_33 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 406.0
PYH2_k127_1931827_34 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 405.0
PYH2_k127_1931827_35 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 386.0
PYH2_k127_1931827_36 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 368.0
PYH2_k127_1931827_37 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 368.0
PYH2_k127_1931827_38 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 347.0
PYH2_k127_1931827_39 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 338.0
PYH2_k127_1931827_4 Uncharacterized membrane protein (DUF2298) - - - 5.742e-226 721.0
PYH2_k127_1931827_40 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008722 314.0
PYH2_k127_1931827_41 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000503 299.0
PYH2_k127_1931827_42 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 300.0
PYH2_k127_1931827_43 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 294.0
PYH2_k127_1931827_44 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 287.0
PYH2_k127_1931827_45 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 291.0
PYH2_k127_1931827_46 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009896 291.0
PYH2_k127_1931827_47 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 282.0
PYH2_k127_1931827_48 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001832 284.0
PYH2_k127_1931827_49 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008287 270.0
PYH2_k127_1931827_5 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 2.856e-225 704.0
PYH2_k127_1931827_50 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007312 259.0
PYH2_k127_1931827_51 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002727 254.0
PYH2_k127_1931827_52 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001297 246.0
PYH2_k127_1931827_53 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000329 236.0
PYH2_k127_1931827_54 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000268 231.0
PYH2_k127_1931827_55 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000003812 222.0
PYH2_k127_1931827_56 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000306 218.0
PYH2_k127_1931827_57 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000008434 216.0
PYH2_k127_1931827_58 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000001864 205.0
PYH2_k127_1931827_59 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000006733 199.0
PYH2_k127_1931827_6 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 2.179e-209 660.0
PYH2_k127_1931827_60 - - - - 0.000000000000000000000000000000000000000000000000003429 196.0
PYH2_k127_1931827_61 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000002906 188.0
PYH2_k127_1931827_62 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000419 171.0
PYH2_k127_1931827_63 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000156 161.0
PYH2_k127_1931827_64 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.000000000000000000000000000000000000000005867 158.0
PYH2_k127_1931827_65 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000002557 149.0
PYH2_k127_1931827_66 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000004979 158.0
PYH2_k127_1931827_67 - - - - 0.000000000000000000000000000000000000001483 155.0
PYH2_k127_1931827_68 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000876 147.0
PYH2_k127_1931827_69 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000001811 145.0
PYH2_k127_1931827_7 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 7.642e-205 649.0
PYH2_k127_1931827_70 - - - - 0.000000000000000000000000000000000002804 139.0
PYH2_k127_1931827_71 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000002887 134.0
PYH2_k127_1931827_72 Peptidyl-prolyl cis-trans K01802,K03768,K03775 - 5.2.1.8 0.000000000000000000000000000000007516 136.0
PYH2_k127_1931827_73 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000003484 114.0
PYH2_k127_1931827_74 helicase activity K06915 - - 0.00000000000000000000000000375 117.0
PYH2_k127_1931827_75 Rhodanese Homology Domain - - - 0.0000000000000000000000001553 110.0
PYH2_k127_1931827_76 - - - - 0.0000000000000000000000006239 109.0
PYH2_k127_1931827_77 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000003533 105.0
PYH2_k127_1931827_78 Putative small multi-drug export protein - - - 0.00000000000000001014 89.0
PYH2_k127_1931827_79 - - - - 0.00000000000000003862 89.0
PYH2_k127_1931827_8 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 4.033e-204 641.0
PYH2_k127_1931827_80 - - - - 0.0000000000001994 72.0
PYH2_k127_1931827_9 Involved in cell shape control K22222 - - 7.975e-197 621.0
PYH2_k127_2003842_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 3.909e-233 734.0
PYH2_k127_2003842_1 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 531.0
PYH2_k127_2003842_10 TIR domain - - - 0.000000000000002548 81.0
PYH2_k127_2003842_11 - - - - 0.0000000003346 70.0
PYH2_k127_2003842_12 - - - - 0.00001739 51.0
PYH2_k127_2003842_2 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 439.0
PYH2_k127_2003842_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 406.0
PYH2_k127_2003842_4 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 361.0
PYH2_k127_2003842_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 289.0
PYH2_k127_2003842_6 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002064 284.0
PYH2_k127_2003842_7 - - - - 0.0000000000000000000000000000000000000000000000000000002909 198.0
PYH2_k127_2003842_8 Flavodoxin - - - 0.000000000000000000000000000000000000000004846 160.0
PYH2_k127_2003842_9 - - - - 0.00000000000000000000000000000000007983 136.0
PYH2_k127_2041842_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1519.0
PYH2_k127_2041842_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 4.034e-266 832.0
PYH2_k127_2041842_10 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 546.0
PYH2_k127_2041842_11 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 526.0
PYH2_k127_2041842_12 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 504.0
PYH2_k127_2041842_13 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 501.0
PYH2_k127_2041842_14 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007341 466.0
PYH2_k127_2041842_15 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 457.0
PYH2_k127_2041842_16 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005433 461.0
PYH2_k127_2041842_17 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 437.0
PYH2_k127_2041842_18 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 433.0
PYH2_k127_2041842_19 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 422.0
PYH2_k127_2041842_2 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 9.197e-246 773.0
PYH2_k127_2041842_20 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 417.0
PYH2_k127_2041842_21 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 402.0
PYH2_k127_2041842_22 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 389.0
PYH2_k127_2041842_23 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 384.0
PYH2_k127_2041842_24 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005886 377.0
PYH2_k127_2041842_25 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 372.0
PYH2_k127_2041842_26 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 353.0
PYH2_k127_2041842_27 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 323.0
PYH2_k127_2041842_28 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 301.0
PYH2_k127_2041842_29 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
PYH2_k127_2041842_3 Predicted membrane protein (DUF2070) K08979 - - 7.917e-205 652.0
PYH2_k127_2041842_30 methanogen marker protein 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 287.0
PYH2_k127_2041842_31 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009959 272.0
PYH2_k127_2041842_32 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001398 274.0
PYH2_k127_2041842_33 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007968 280.0
PYH2_k127_2041842_34 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001239 270.0
PYH2_k127_2041842_35 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004169 267.0
PYH2_k127_2041842_36 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006101 257.0
PYH2_k127_2041842_37 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003403 253.0
PYH2_k127_2041842_38 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001278 237.0
PYH2_k127_2041842_39 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000528 204.0
PYH2_k127_2041842_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.131e-198 623.0
PYH2_k127_2041842_40 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000000000000000000007978 190.0
PYH2_k127_2041842_41 Pas domain - - - 0.00000000000000000000000000000000000000000000000000005001 213.0
PYH2_k127_2041842_42 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000004759 190.0
PYH2_k127_2041842_43 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000000005464 164.0
PYH2_k127_2041842_44 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000009351 164.0
PYH2_k127_2041842_45 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000002457 156.0
PYH2_k127_2041842_46 Pas domain - - - 0.0000000000000000000000000000000000001049 164.0
PYH2_k127_2041842_47 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000006937 130.0
PYH2_k127_2041842_48 PFAM PRC-barrel domain - - - 0.000000000000000000000000000002019 122.0
PYH2_k127_2041842_49 transcription factor (CBF NF-Y) - - - 0.000000000000000000000000002823 114.0
PYH2_k127_2041842_5 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 607.0
PYH2_k127_2041842_50 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000003905 121.0
PYH2_k127_2041842_51 Family of unknown function (DUF5350) - - - 0.000000000000000000000002727 105.0
PYH2_k127_2041842_52 PFAM TPR repeat-containing protein - - - 0.0000000000000000000007972 98.0
PYH2_k127_2041842_53 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000001973 91.0
PYH2_k127_2041842_54 - - - - 0.000000000000000002679 85.0
PYH2_k127_2041842_55 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000008994 82.0
PYH2_k127_2041842_56 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00007111 51.0
PYH2_k127_2041842_6 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 609.0
PYH2_k127_2041842_7 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 587.0
PYH2_k127_2041842_8 PFAM Aldehyde dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 569.0
PYH2_k127_2041842_9 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 547.0
PYH2_k127_2232148_0 DEAD DEAH box helicase K06877 - - 2.154e-284 893.0
PYH2_k127_2232148_1 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 403.0
PYH2_k127_2232148_2 PFAM Linocin_M18 bacteriocin protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 322.0
PYH2_k127_2232148_3 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 293.0
PYH2_k127_2232148_4 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001082 246.0
PYH2_k127_2232148_5 Rubrerythrin - - - 0.00000000000000000000000000000000001721 138.0
PYH2_k127_2416051_0 PFAM Radical SAM domain protein K06937 - - 2.077e-244 762.0
PYH2_k127_2416051_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 6.335e-194 614.0
PYH2_k127_2416051_10 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000006707 152.0
PYH2_k127_2416051_11 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000007972 98.0
PYH2_k127_2416051_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 554.0
PYH2_k127_2416051_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 487.0
PYH2_k127_2416051_4 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 436.0
PYH2_k127_2416051_5 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 422.0
PYH2_k127_2416051_6 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 360.0
PYH2_k127_2416051_7 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000000000002255 212.0
PYH2_k127_2416051_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000004379 188.0
PYH2_k127_2416051_9 Small multi-drug export protein - - - 0.00000000000000000000000000000000000000000006819 170.0
PYH2_k127_2466411_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.424e-293 909.0
PYH2_k127_2466411_1 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.311e-281 874.0
PYH2_k127_2466411_10 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 475.0
PYH2_k127_2466411_11 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 429.0
PYH2_k127_2466411_12 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 424.0
PYH2_k127_2466411_13 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 380.0
PYH2_k127_2466411_14 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 361.0
PYH2_k127_2466411_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 361.0
PYH2_k127_2466411_16 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 349.0
PYH2_k127_2466411_17 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 348.0
PYH2_k127_2466411_18 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 331.0
PYH2_k127_2466411_19 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 325.0
PYH2_k127_2466411_2 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 1.789e-261 812.0
PYH2_k127_2466411_20 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 327.0
PYH2_k127_2466411_21 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 306.0
PYH2_k127_2466411_22 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 297.0
PYH2_k127_2466411_23 amino acid transport K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004286 272.0
PYH2_k127_2466411_24 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000005641 266.0
PYH2_k127_2466411_25 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001722 271.0
PYH2_k127_2466411_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001512 244.0
PYH2_k127_2466411_27 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000005267 222.0
PYH2_k127_2466411_28 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000004422 216.0
PYH2_k127_2466411_29 PFAM ABC transporter K16787 - - 0.0000000000000000000000000000000000000000000000000000000000005326 218.0
PYH2_k127_2466411_3 Protein of unknown function (DUF460) K09150 - - 2.724e-255 802.0
PYH2_k127_2466411_30 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000001519 220.0
PYH2_k127_2466411_31 PFAM transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000002406 217.0
PYH2_k127_2466411_32 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000000000006705 211.0
PYH2_k127_2466411_33 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000005321 200.0
PYH2_k127_2466411_34 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000005965 192.0
PYH2_k127_2466411_35 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000000000000005754 188.0
PYH2_k127_2466411_36 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000002547 184.0
PYH2_k127_2466411_37 - - - - 0.00000000000000000000000000000000000000000000007959 179.0
PYH2_k127_2466411_38 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000000000001302 171.0
PYH2_k127_2466411_39 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000001252 138.0
PYH2_k127_2466411_4 Belongs to the RtcB family K14415 - 6.5.1.3 1.95e-228 715.0
PYH2_k127_2466411_40 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000001245 127.0
PYH2_k127_2466411_41 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000006901 128.0
PYH2_k127_2466411_42 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000001814 108.0
PYH2_k127_2466411_43 - - - - 0.000000000000000000000001316 106.0
PYH2_k127_2466411_44 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000000000000001842 101.0
PYH2_k127_2466411_45 of cations and cationic drugs K11741 - - 0.0000000000429 66.0
PYH2_k127_2466411_46 Small Multidrug Resistance protein K11741 - - 0.00001155 48.0
PYH2_k127_2466411_47 - - - - 0.00003847 54.0
PYH2_k127_2466411_48 4Fe-4S binding domain K03616 - - 0.00003852 47.0
PYH2_k127_2466411_49 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0004591 45.0
PYH2_k127_2466411_5 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 8.499e-203 635.0
PYH2_k127_2466411_6 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 597.0
PYH2_k127_2466411_7 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 540.0
PYH2_k127_2466411_8 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 501.0
PYH2_k127_2466411_9 Phosphate transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 512.0
PYH2_k127_2546471_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1167.0
PYH2_k127_2546471_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.687e-264 825.0
PYH2_k127_2546471_10 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 423.0
PYH2_k127_2546471_11 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 411.0
PYH2_k127_2546471_12 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 372.0
PYH2_k127_2546471_13 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 369.0
PYH2_k127_2546471_14 SPFH Band 7 PHB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 370.0
PYH2_k127_2546471_15 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 366.0
PYH2_k127_2546471_16 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 341.0
PYH2_k127_2546471_17 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 304.0
PYH2_k127_2546471_18 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001652 282.0
PYH2_k127_2546471_19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000001004 222.0
PYH2_k127_2546471_2 AAA-like domain K06915 - - 2.414e-236 741.0
PYH2_k127_2546471_20 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.000000000000000000000000000000000000000000000000000000000004742 212.0
PYH2_k127_2546471_21 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000009108 190.0
PYH2_k127_2546471_22 positive regulation of acetylcholine metabolic process K06910 - - 0.000000000000000000000000000000000000000000000000003472 186.0
PYH2_k127_2546471_23 PFAM RDD domain containing protein - - - 0.0000000000000000000000000000000000000000002439 163.0
PYH2_k127_2546471_24 membrane protein domain - - - 0.00000000000000000000000000000000000000002089 160.0
PYH2_k127_2546471_25 - - - - 0.0000000000000000000000000000000000001042 149.0
PYH2_k127_2546471_27 - K03686 - - 0.000000000000001743 79.0
PYH2_k127_2546471_28 - K06868 - 2.5.1.73 0.0000000000009565 69.0
PYH2_k127_2546471_3 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 576.0
PYH2_k127_2546471_4 COG1668 ABC-type Na efflux pump, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 567.0
PYH2_k127_2546471_5 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 515.0
PYH2_k127_2546471_6 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 471.0
PYH2_k127_2546471_7 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 443.0
PYH2_k127_2546471_8 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 435.0
PYH2_k127_2546471_9 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 422.0
PYH2_k127_265580_0 Heat shock 70 kDa protein K04043 - - 3.612e-319 984.0
PYH2_k127_265580_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 6.154e-291 900.0
PYH2_k127_265580_10 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000000000000000000000000000000000006355 206.0
PYH2_k127_265580_11 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000000000001911 193.0
PYH2_k127_265580_12 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000975 188.0
PYH2_k127_265580_13 DNA ligase D, 3-phosphoesterase domain - - - 0.000000000000000000000000000000000000000000000000007892 184.0
PYH2_k127_265580_14 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000002143 156.0
PYH2_k127_265580_15 COG0328 Ribonuclease HI K03469 - 3.1.26.4 0.000000000000000000000000000005503 124.0
PYH2_k127_265580_16 fibronectin type III domain protein - - - 0.0000000000000000000000000003903 131.0
PYH2_k127_265580_17 - - - - 0.0000000000000000000000000006991 115.0
PYH2_k127_265580_18 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000009735 117.0
PYH2_k127_265580_19 Peptidase dimerisation domain - - - 0.00000000000000002147 84.0
PYH2_k127_265580_2 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 3.202e-238 744.0
PYH2_k127_265580_20 Zinc metalloprotease (Elastase) - - - 0.00000000000002097 87.0
PYH2_k127_265580_21 Uncharacterised ArCR, COG2043 - - - 0.000000000000421 70.0
PYH2_k127_265580_22 Uncharacterised ArCR, COG2043 - - - 0.000002557 51.0
PYH2_k127_265580_23 CARDB - - - 0.0000565 56.0
PYH2_k127_265580_3 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 6.716e-228 718.0
PYH2_k127_265580_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 529.0
PYH2_k127_265580_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 466.0
PYH2_k127_265580_6 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 368.0
PYH2_k127_265580_7 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 363.0
PYH2_k127_265580_8 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 340.0
PYH2_k127_265580_9 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001538 271.0
PYH2_k127_2804644_0 SMART Elongator protein 3 MiaB NifB - - - 1.101e-233 733.0
PYH2_k127_2804644_1 phosphoesterase RecJ domain protein - - - 1.531e-202 642.0
PYH2_k127_2804644_2 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 379.0
PYH2_k127_2804644_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006707 280.0
PYH2_k127_2823455_0 Belongs to the glutamate synthase family - - - 6.829e-274 849.0
PYH2_k127_2823455_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 1.335e-202 634.0
PYH2_k127_2823455_2 PFAM glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 542.0
PYH2_k127_2823455_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 438.0
PYH2_k127_2823455_4 PFAM glutamate synthase alpha subunit domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 333.0
PYH2_k127_2823455_5 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002518 289.0
PYH2_k127_2823455_6 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000005781 93.0
PYH2_k127_2823455_7 PFAM PKD domain containing protein - - - 0.0000000000004216 79.0
PYH2_k127_2823455_8 - - - - 0.00006055 57.0
PYH2_k127_2850844_0 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 595.0
PYH2_k127_2850844_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009228 576.0
PYH2_k127_2850844_10 Protein of unknown function (DUF2769) - - - 0.000000000000000000000007932 105.0
PYH2_k127_2850844_11 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.000000000949 73.0
PYH2_k127_2850844_2 PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 547.0
PYH2_k127_2850844_3 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007541 476.0
PYH2_k127_2850844_4 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 460.0
PYH2_k127_2850844_5 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 409.0
PYH2_k127_2850844_6 PFAM glutamate--cysteine ligase, GCS2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 398.0
PYH2_k127_2850844_7 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 344.0
PYH2_k127_2850844_8 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000001361 226.0
PYH2_k127_2850844_9 Thioredoxin - - - 0.0000000000000000000000000000000000000000003576 164.0
PYH2_k127_2915116_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 1.023e-259 807.0
PYH2_k127_2915116_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 8.772e-203 646.0
PYH2_k127_2915116_10 - - - - 0.00000000000000000000006187 100.0
PYH2_k127_2915116_11 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000105 50.0
PYH2_k127_2915116_2 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008754 275.0
PYH2_k127_2915116_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006396 301.0
PYH2_k127_2915116_4 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001516 278.0
PYH2_k127_2915116_5 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002901 241.0
PYH2_k127_2915116_6 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000000000001497 225.0
PYH2_k127_2915116_7 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000000000000000000000005172 209.0
PYH2_k127_2915116_8 - - - - 0.000000000000000000000000000000000008749 139.0
PYH2_k127_2915116_9 Glutaredoxin - - - 0.0000000000000000000000000000000002621 136.0
PYH2_k127_2979680_0 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 539.0
PYH2_k127_2979680_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 507.0
PYH2_k127_2979680_2 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 443.0
PYH2_k127_2979680_3 Alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 364.0
PYH2_k127_2979680_4 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001519 232.0
PYH2_k127_2979680_5 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000402 101.0
PYH2_k127_2979680_7 Short repeat of unknown function (DUF308) - - - 0.000000001542 61.0
PYH2_k127_2979680_8 Domain of unknown function (DUF3821) - - - 0.0000008507 51.0
PYH2_k127_2979680_9 VIT family - - - 0.000001304 58.0
PYH2_k127_2980445_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1851.0
PYH2_k127_2980445_1 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1233.0
PYH2_k127_2980445_10 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 3.123e-206 648.0
PYH2_k127_2980445_100 Protein of unknown function DUF86 K07075 - - 0.00000000000000000000005211 107.0
PYH2_k127_2980445_101 Trm112p-like protein - - - 0.000000000000000000505 87.0
PYH2_k127_2980445_102 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.0000000000002127 72.0
PYH2_k127_2980445_103 Domain of unknown function (DUF3821) - - - 0.00000000000037 76.0
PYH2_k127_2980445_104 SMART PAS domain containing protein - - - 0.00000000002457 76.0
PYH2_k127_2980445_105 - - - - 0.000000004009 65.0
PYH2_k127_2980445_106 - - - - 0.00000001341 63.0
PYH2_k127_2980445_11 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 2.411e-205 647.0
PYH2_k127_2980445_12 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 3.274e-194 616.0
PYH2_k127_2980445_13 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 612.0
PYH2_k127_2980445_14 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 586.0
PYH2_k127_2980445_15 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 584.0
PYH2_k127_2980445_16 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 587.0
PYH2_k127_2980445_17 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 578.0
PYH2_k127_2980445_18 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 568.0
PYH2_k127_2980445_19 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006841 567.0
PYH2_k127_2980445_2 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 2.808e-298 928.0
PYH2_k127_2980445_20 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 547.0
PYH2_k127_2980445_21 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 544.0
PYH2_k127_2980445_22 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 529.0
PYH2_k127_2980445_23 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 527.0
PYH2_k127_2980445_24 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 520.0
PYH2_k127_2980445_25 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 517.0
PYH2_k127_2980445_26 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 493.0
PYH2_k127_2980445_27 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 477.0
PYH2_k127_2980445_28 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 478.0
PYH2_k127_2980445_29 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 484.0
PYH2_k127_2980445_3 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.585e-284 890.0
PYH2_k127_2980445_30 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 463.0
PYH2_k127_2980445_31 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008367 466.0
PYH2_k127_2980445_32 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006172 475.0
PYH2_k127_2980445_33 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009093 416.0
PYH2_k127_2980445_34 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 406.0
PYH2_k127_2980445_35 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 410.0
PYH2_k127_2980445_36 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 398.0
PYH2_k127_2980445_37 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 379.0
PYH2_k127_2980445_38 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 375.0
PYH2_k127_2980445_39 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 374.0
PYH2_k127_2980445_4 PFAM ABC transporter K00400 - - 2.718e-281 871.0
PYH2_k127_2980445_40 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 366.0
PYH2_k127_2980445_41 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 360.0
PYH2_k127_2980445_42 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 340.0
PYH2_k127_2980445_43 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 340.0
PYH2_k127_2980445_44 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
PYH2_k127_2980445_45 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 329.0
PYH2_k127_2980445_46 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 329.0
PYH2_k127_2980445_47 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 325.0
PYH2_k127_2980445_48 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 316.0
PYH2_k127_2980445_49 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 312.0
PYH2_k127_2980445_5 SMART Elongator protein 3 MiaB NifB - - - 1.536e-259 812.0
PYH2_k127_2980445_50 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 290.0
PYH2_k127_2980445_51 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 310.0
PYH2_k127_2980445_52 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 282.0
PYH2_k127_2980445_53 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 281.0
PYH2_k127_2980445_54 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000101 281.0
PYH2_k127_2980445_55 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
PYH2_k127_2980445_56 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001972 273.0
PYH2_k127_2980445_57 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000362 269.0
PYH2_k127_2980445_58 O-methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005082 270.0
PYH2_k127_2980445_59 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005911 269.0
PYH2_k127_2980445_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.102e-254 788.0
PYH2_k127_2980445_60 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000002476 270.0
PYH2_k127_2980445_61 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002634 267.0
PYH2_k127_2980445_62 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008031 267.0
PYH2_k127_2980445_63 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000001187 270.0
PYH2_k127_2980445_64 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000001605 264.0
PYH2_k127_2980445_65 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
PYH2_k127_2980445_66 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009094 248.0
PYH2_k127_2980445_67 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006597 251.0
PYH2_k127_2980445_68 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000007568 238.0
PYH2_k127_2980445_69 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000001594 238.0
PYH2_k127_2980445_7 Involved in regulation of DNA replication K10725 - - 9.512e-219 685.0
PYH2_k127_2980445_70 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001532 236.0
PYH2_k127_2980445_71 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002725 233.0
PYH2_k127_2980445_72 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002081 232.0
PYH2_k127_2980445_73 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000002456 227.0
PYH2_k127_2980445_74 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000003464 217.0
PYH2_k127_2980445_75 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000000000000003467 214.0
PYH2_k127_2980445_76 Protein of unknown function (DUF432) K09149 - - 0.0000000000000000000000000000000000000000000000000000000000005707 218.0
PYH2_k127_2980445_77 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000001401 210.0
PYH2_k127_2980445_78 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000007345 202.0
PYH2_k127_2980445_79 - - - - 0.00000000000000000000000000000000000000000000000000000003323 209.0
PYH2_k127_2980445_8 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.22e-216 677.0
PYH2_k127_2980445_80 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000005076 204.0
PYH2_k127_2980445_81 PFAM response regulator receiveR - - - 0.000000000000000000000000000000000000000000000000007439 185.0
PYH2_k127_2980445_82 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000005411 186.0
PYH2_k127_2980445_83 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000001119 179.0
PYH2_k127_2980445_84 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000002924 184.0
PYH2_k127_2980445_85 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000000001518 172.0
PYH2_k127_2980445_86 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001464 171.0
PYH2_k127_2980445_87 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000002714 175.0
PYH2_k127_2980445_88 Yip1 domain - - - 0.0000000000000000000000000000000000000000000804 168.0
PYH2_k127_2980445_89 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000006108 164.0
PYH2_k127_2980445_9 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 9.998e-212 666.0
PYH2_k127_2980445_90 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000000007337 159.0
PYH2_k127_2980445_91 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000000000000000000001369 166.0
PYH2_k127_2980445_92 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000004662 148.0
PYH2_k127_2980445_93 - - - - 0.0000000000000000000000000000000000004706 145.0
PYH2_k127_2980445_94 - - - - 0.000000000000000000000000000000000005066 143.0
PYH2_k127_2980445_95 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000005463 141.0
PYH2_k127_2980445_96 Condensation domain - - - 0.0000000000000000000000000000000007568 146.0
PYH2_k127_2980445_97 Domain of unknown function (DUF1805) - - - 0.000000000000000000000000000000131 126.0
PYH2_k127_2980445_98 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000003443 130.0
PYH2_k127_2980445_99 Transcriptional regulator K07729 - - 0.0000000000000000000000006156 107.0
PYH2_k127_3027421_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 3.367e-255 802.0
PYH2_k127_3027421_1 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 2.699e-224 700.0
PYH2_k127_3027421_10 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
PYH2_k127_3027421_11 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000004408 222.0
PYH2_k127_3027421_12 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000003255 218.0
PYH2_k127_3027421_13 - - - - 0.0000000000000000000000000000000000000000000000000000007167 197.0
PYH2_k127_3027421_14 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000000001027 194.0
PYH2_k127_3027421_15 Nitroreductase - - - 0.000000000000000000000000000000000000000000000002732 186.0
PYH2_k127_3027421_16 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000001597 171.0
PYH2_k127_3027421_17 - - - - 0.0000000000000000000000000000000000000003116 158.0
PYH2_k127_3027421_18 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000000000000000000003817 141.0
PYH2_k127_3027421_19 PFAM helix-turn-helix domain protein K07729 - - 0.000000000000000000000000000193 116.0
PYH2_k127_3027421_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 466.0
PYH2_k127_3027421_20 PFAM Uncharacterised protein family UPF0066 - - - 0.00000000000000000007464 92.0
PYH2_k127_3027421_21 transcriptional regulators K03724 - - 0.0000000000000000634 82.0
PYH2_k127_3027421_22 Rubredoxin - - - 0.000000000000001586 79.0
PYH2_k127_3027421_23 PQ loop repeat K15383 - - 0.00000004942 59.0
PYH2_k127_3027421_3 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 414.0
PYH2_k127_3027421_4 methanogenesis marker protein 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 418.0
PYH2_k127_3027421_5 permease K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 394.0
PYH2_k127_3027421_6 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 387.0
PYH2_k127_3027421_7 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 338.0
PYH2_k127_3027421_8 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 312.0
PYH2_k127_3027421_9 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 299.0
PYH2_k127_3083802_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.417e-227 710.0
PYH2_k127_3083802_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 1.689e-223 711.0
PYH2_k127_3083802_10 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 300.0
PYH2_k127_3083802_11 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 296.0
PYH2_k127_3083802_12 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 293.0
PYH2_k127_3083802_13 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000000000005868 256.0
PYH2_k127_3083802_14 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000000000000000000000000000000001323 238.0
PYH2_k127_3083802_15 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000008763 235.0
PYH2_k127_3083802_16 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000000756 222.0
PYH2_k127_3083802_17 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000000000000000000000000000000004101 220.0
PYH2_k127_3083802_18 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000005101 209.0
PYH2_k127_3083802_19 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000000002543 176.0
PYH2_k127_3083802_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 1.078e-194 615.0
PYH2_k127_3083802_20 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000000003396 171.0
PYH2_k127_3083802_21 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000007592 153.0
PYH2_k127_3083802_22 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000003406 152.0
PYH2_k127_3083802_23 DNA polymerase activity K02319 - 2.7.7.7 0.000000000000000000000000000000000002766 145.0
PYH2_k127_3083802_24 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000003097 137.0
PYH2_k127_3083802_25 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000000001048 127.0
PYH2_k127_3083802_26 Proline dehydrogenase K00318 GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.000000000000000000000004718 112.0
PYH2_k127_3083802_27 CRS1_YhbY K07574 - - 0.0000000000000000000001528 99.0
PYH2_k127_3083802_28 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000009148 87.0
PYH2_k127_3083802_29 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000002144 85.0
PYH2_k127_3083802_3 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 542.0
PYH2_k127_3083802_31 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000007725 64.0
PYH2_k127_3083802_32 - - - - 0.00000000188 63.0
PYH2_k127_3083802_33 - - - - 0.000000005114 58.0
PYH2_k127_3083802_34 - - - - 0.000001569 58.0
PYH2_k127_3083802_4 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 542.0
PYH2_k127_3083802_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 466.0
PYH2_k127_3083802_6 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 376.0
PYH2_k127_3083802_7 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 346.0
PYH2_k127_3083802_8 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 317.0
PYH2_k127_3083802_9 NAD(P)H dehydrogenase (quinone) activity K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009361 308.0
PYH2_k127_3285897_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1403.0
PYH2_k127_3285897_1 PFAM PilT protein domain protein K06865 - - 2.029e-303 940.0
PYH2_k127_3285897_10 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000003624 269.0
PYH2_k127_3285897_11 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000003099 193.0
PYH2_k127_3285897_12 Roadblock LC7 K07131 - - 0.0000000000000000000000000000000000000000000000000001555 186.0
PYH2_k127_3285897_13 Protein of unknown function (DUF473) K09135 - - 0.000000000000000000000000000000000000000002447 160.0
PYH2_k127_3285897_14 - - - - 0.000000000000000000000000000000000000000005723 161.0
PYH2_k127_3285897_15 - - - - 0.00000000000000000000000000000000002051 137.0
PYH2_k127_3285897_16 Roadblock LC7 - - - 0.000000000000000000000000000004726 125.0
PYH2_k127_3285897_17 - - - - 0.0000000000000000000000001891 114.0
PYH2_k127_3285897_18 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000009525 85.0
PYH2_k127_3285897_19 - - - - 0.0000002532 59.0
PYH2_k127_3285897_2 PFAM type II secretion system protein E K07332 - - 9.429e-276 865.0
PYH2_k127_3285897_20 COG1403 Restriction endonuclease K10726 - - 0.0001385 46.0
PYH2_k127_3285897_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 6.903e-274 853.0
PYH2_k127_3285897_4 PFAM 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 603.0
PYH2_k127_3285897_5 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 575.0
PYH2_k127_3285897_6 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 377.0
PYH2_k127_3285897_7 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 369.0
PYH2_k127_3285897_8 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 356.0
PYH2_k127_3285897_9 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 355.0
PYH2_k127_3364738_0 Ferrous iron transport B domain protein K04759 - - 3.469e-227 719.0
PYH2_k127_3364738_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.003e-211 662.0
PYH2_k127_3364738_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 484.0
PYH2_k127_3364738_11 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 430.0
PYH2_k127_3364738_12 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 422.0
PYH2_k127_3364738_13 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 391.0
PYH2_k127_3364738_14 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 395.0
PYH2_k127_3364738_15 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 377.0
PYH2_k127_3364738_16 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 372.0
PYH2_k127_3364738_17 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 370.0
PYH2_k127_3364738_18 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 360.0
PYH2_k127_3364738_19 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 330.0
PYH2_k127_3364738_2 Helix-hairpin-helix domain K02347 - - 5.658e-199 634.0
PYH2_k127_3364738_20 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 307.0
PYH2_k127_3364738_21 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 298.0
PYH2_k127_3364738_22 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 298.0
PYH2_k127_3364738_23 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001116 273.0
PYH2_k127_3364738_24 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000004071 238.0
PYH2_k127_3364738_25 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000001047 222.0
PYH2_k127_3364738_26 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000004547 216.0
PYH2_k127_3364738_27 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000001114 207.0
PYH2_k127_3364738_28 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000000000000000000000000000000000000006403 206.0
PYH2_k127_3364738_29 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000007372 201.0
PYH2_k127_3364738_3 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 4.801e-197 616.0
PYH2_k127_3364738_30 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000004559 201.0
PYH2_k127_3364738_31 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000007647 186.0
PYH2_k127_3364738_32 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000000000000000000000000003141 174.0
PYH2_k127_3364738_33 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000000000000000005914 166.0
PYH2_k127_3364738_34 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000005093 166.0
PYH2_k127_3364738_35 iron dependent repressor K03709,K04758 - - 0.00000000000000000000000000000000000000002004 160.0
PYH2_k127_3364738_36 - - - - 0.00000000000000000000000000000000007694 134.0
PYH2_k127_3364738_37 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000000000000005648 136.0
PYH2_k127_3364738_38 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000004044 115.0
PYH2_k127_3364738_39 - - - - 0.0000000000000000000001307 104.0
PYH2_k127_3364738_4 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 594.0
PYH2_k127_3364738_40 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000001866 100.0
PYH2_k127_3364738_41 PFAM TPR repeat-containing protein - - - 0.0000000000000002518 84.0
PYH2_k127_3364738_42 PFAM TPR repeat-containing protein - - - 0.0000000000000005081 83.0
PYH2_k127_3364738_43 - - - - 0.000000000000000739 78.0
PYH2_k127_3364738_44 PFAM Cation K03498 - - 0.00000000006293 64.0
PYH2_k127_3364738_46 TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0007745 42.0
PYH2_k127_3364738_5 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 589.0
PYH2_k127_3364738_6 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 561.0
PYH2_k127_3364738_7 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 542.0
PYH2_k127_3364738_8 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 534.0
PYH2_k127_3364738_9 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 505.0
PYH2_k127_3501090_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1010.0
PYH2_k127_3501090_1 2Fe-2S iron-sulfur cluster binding domain - - - 4.125e-302 938.0
PYH2_k127_3501090_2 Nitrogenase component 1 type Oxidoreductase K02587 - - 1.211e-274 848.0
PYH2_k127_3501090_3 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 2.531e-241 752.0
PYH2_k127_3501090_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 595.0
PYH2_k127_3501090_5 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 486.0
PYH2_k127_3501090_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 451.0
PYH2_k127_3501090_7 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009922 393.0
PYH2_k127_3501090_8 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 312.0
PYH2_k127_3501090_9 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.00000002525 55.0
PYH2_k127_3774226_0 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 446.0
PYH2_k127_3774226_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000005252 172.0
PYH2_k127_3774226_2 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000003076 146.0
PYH2_k127_3774226_3 SpoVT / AbrB like domain - - - 0.000000000000000000000000001442 114.0
PYH2_k127_38813_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1148.0
PYH2_k127_38813_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 3.999e-257 801.0
PYH2_k127_38813_10 - - - - 0.000000000000000000000000000000000001004 143.0
PYH2_k127_38813_11 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000003825 136.0
PYH2_k127_38813_12 TPR repeat Sel1-like repeat Tetratricopeptide TPR_3 Tetratricopeptide TPR_2 - - - 0.00002851 55.0
PYH2_k127_38813_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 466.0
PYH2_k127_38813_3 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 429.0
PYH2_k127_38813_4 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005759 246.0
PYH2_k127_38813_5 Domain of unknown function (DUF1724) - - - 0.00000000000000000000000000000000000000000000000000000000000000002575 232.0
PYH2_k127_38813_6 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000002736 209.0
PYH2_k127_38813_7 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000001158 198.0
PYH2_k127_38813_8 NTPase - - - 0.00000000000000000000000000000000000000000000000000409 186.0
PYH2_k127_38813_9 Belongs to the UPF0216 family K09737 - - 0.000000000000000000000000000000000000000001191 163.0
PYH2_k127_3939780_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 365.0
PYH2_k127_3939780_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000002199 245.0
PYH2_k127_3939780_2 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000001997 227.0
PYH2_k127_4022725_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 5.349e-263 815.0
PYH2_k127_4022725_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 1.637e-214 670.0
PYH2_k127_4022725_2 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000003846 191.0
PYH2_k127_4022725_3 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000002693 97.0
PYH2_k127_4032171_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 3.873e-253 788.0
PYH2_k127_4032171_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.773e-242 757.0
PYH2_k127_4032171_10 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 377.0
PYH2_k127_4032171_11 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 363.0
PYH2_k127_4032171_12 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 360.0
PYH2_k127_4032171_13 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 363.0
PYH2_k127_4032171_14 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 355.0
PYH2_k127_4032171_15 Uncharacterised conserved protein (DUF2156) K01163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
PYH2_k127_4032171_16 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 325.0
PYH2_k127_4032171_17 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 296.0
PYH2_k127_4032171_18 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004814 271.0
PYH2_k127_4032171_19 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009365 263.0
PYH2_k127_4032171_2 AMP-binding enzyme - - - 5.783e-211 664.0
PYH2_k127_4032171_20 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001375 254.0
PYH2_k127_4032171_21 Oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006221 264.0
PYH2_k127_4032171_22 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004786 244.0
PYH2_k127_4032171_23 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006486 242.0
PYH2_k127_4032171_24 Integral membrane protein DUF106 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001335 241.0
PYH2_k127_4032171_25 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000021 238.0
PYH2_k127_4032171_26 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000004074 237.0
PYH2_k127_4032171_27 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004203 252.0
PYH2_k127_4032171_28 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000006829 233.0
PYH2_k127_4032171_29 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000000008799 232.0
PYH2_k127_4032171_3 PFAM Radical SAM domain protein K06871 - - 4.908e-196 616.0
PYH2_k127_4032171_30 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000001459 228.0
PYH2_k127_4032171_31 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000000000000000005475 222.0
PYH2_k127_4032171_32 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000008358 217.0
PYH2_k127_4032171_33 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000003935 217.0
PYH2_k127_4032171_34 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000001059 209.0
PYH2_k127_4032171_35 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000001959 194.0
PYH2_k127_4032171_36 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000000000000000004129 185.0
PYH2_k127_4032171_37 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000005482 181.0
PYH2_k127_4032171_38 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000001945 175.0
PYH2_k127_4032171_39 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000003152 170.0
PYH2_k127_4032171_4 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 9.391e-196 613.0
PYH2_k127_4032171_40 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.00000000000000000000000000000000000000000003716 163.0
PYH2_k127_4032171_41 PFAM Ribosomal protein K02912 - - 0.00000000000000000000000000000000000000002488 156.0
PYH2_k127_4032171_42 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000003432 118.0
PYH2_k127_4032171_43 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000000000002581 106.0
PYH2_k127_4032171_44 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.0000000000000000000000008072 104.0
PYH2_k127_4032171_45 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000000000002181 105.0
PYH2_k127_4032171_46 PBS lyase HEAT-like repeat - - - 0.00000000000008417 78.0
PYH2_k127_4032171_47 Domain of unknown function (DUF3821) - - - 0.00000006605 54.0
PYH2_k127_4032171_48 - - - - 0.0002922 49.0
PYH2_k127_4032171_5 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 588.0
PYH2_k127_4032171_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 539.0
PYH2_k127_4032171_7 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 486.0
PYH2_k127_4032171_8 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 454.0
PYH2_k127_4032171_9 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 417.0
PYH2_k127_409723_0 Belongs to the MCM family K10726 - - 0.0 1077.0
PYH2_k127_409723_1 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 586.0
PYH2_k127_409723_10 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000006383 264.0
PYH2_k127_409723_11 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000001258 237.0
PYH2_k127_409723_12 Papain family cysteine protease - - - 0.000000000000000000000000000000000000000000000001079 196.0
PYH2_k127_409723_13 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000000003878 131.0
PYH2_k127_409723_14 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000000009062 120.0
PYH2_k127_409723_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 507.0
PYH2_k127_409723_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 460.0
PYH2_k127_409723_4 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 377.0
PYH2_k127_409723_5 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 357.0
PYH2_k127_409723_6 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 338.0
PYH2_k127_409723_7 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 334.0
PYH2_k127_409723_8 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 308.0
PYH2_k127_409723_9 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 301.0
PYH2_k127_4177207_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 3.496e-209 664.0
PYH2_k127_4177207_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.71e-205 645.0
PYH2_k127_4177207_2 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 363.0
PYH2_k127_4177207_3 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000002488 196.0
PYH2_k127_4177207_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000001777 122.0
PYH2_k127_4177207_5 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000005304 61.0
PYH2_k127_4263092_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 5.329e-198 625.0
PYH2_k127_4263092_1 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 449.0
PYH2_k127_4263092_2 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008326 296.0
PYH2_k127_4263092_4 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001189 242.0
PYH2_k127_4263092_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000004944 136.0
PYH2_k127_4263092_6 META domain - - - 0.00000004023 61.0
PYH2_k127_4263092_7 PcfJ-like protein - - - 0.0008481 45.0
PYH2_k127_4295_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 582.0
PYH2_k127_4295_1 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 432.0
PYH2_k127_4295_10 - - - - 0.0000000000000000000000000000000000000000000000000001462 200.0
PYH2_k127_4295_11 Fe-S-cluster oxidoreductase - - - 0.0000000000000000000000000000000000000000000009704 168.0
PYH2_k127_4295_12 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000001609 162.0
PYH2_k127_4295_13 - - - - 0.000000000000000000000000000000000000000005215 162.0
PYH2_k127_4295_15 PFAM PKD domain - - - 0.000000000000000000000000002213 126.0
PYH2_k127_4295_16 - - - - 0.0000000000000000000003465 104.0
PYH2_k127_4295_17 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000789 94.0
PYH2_k127_4295_18 - - - - 0.0000000000000001724 83.0
PYH2_k127_4295_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 419.0
PYH2_k127_4295_20 - - - - 0.00000000002738 67.0
PYH2_k127_4295_3 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 352.0
PYH2_k127_4295_4 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 316.0
PYH2_k127_4295_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007025 280.0
PYH2_k127_4295_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005856 268.0
PYH2_k127_4295_7 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002742 239.0
PYH2_k127_4295_8 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000000000000000000000001521 207.0
PYH2_k127_4295_9 - - - - 0.00000000000000000000000000000000000000000000000000004232 202.0
PYH2_k127_4764600_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0 1262.0
PYH2_k127_4764600_1 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 6.037e-225 717.0
PYH2_k127_4764600_2 PFAM amino acid permease-associated region K20265 - - 6.201e-223 699.0
PYH2_k127_4764600_3 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 416.0
PYH2_k127_4764600_4 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 338.0
PYH2_k127_4764600_5 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 308.0
PYH2_k127_4764600_6 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000476 216.0
PYH2_k127_4764600_7 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000004026 178.0
PYH2_k127_4764600_8 - - - - 0.00000000000000000000003601 105.0
PYH2_k127_488842_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.396e-291 901.0
PYH2_k127_488842_1 PFAM Thiolase K00626 - 2.3.1.9 1.829e-212 664.0
PYH2_k127_488842_10 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 411.0
PYH2_k127_488842_11 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 364.0
PYH2_k127_488842_12 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 334.0
PYH2_k127_488842_13 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 317.0
PYH2_k127_488842_14 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 317.0
PYH2_k127_488842_15 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 309.0
PYH2_k127_488842_16 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 289.0
PYH2_k127_488842_17 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 287.0
PYH2_k127_488842_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000099 253.0
PYH2_k127_488842_19 Helix-turn-helix domain protein K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004943 253.0
PYH2_k127_488842_2 PFAM dihydropteroate synthase, DHPS - - - 6.087e-197 624.0
PYH2_k127_488842_20 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000004162 254.0
PYH2_k127_488842_21 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000003333 221.0
PYH2_k127_488842_22 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000000000000000000000000003606 216.0
PYH2_k127_488842_23 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000139 203.0
PYH2_k127_488842_24 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000000000008055 201.0
PYH2_k127_488842_25 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000000000024 192.0
PYH2_k127_488842_26 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000000000000000000000000000000005125 180.0
PYH2_k127_488842_27 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000003895 141.0
PYH2_k127_488842_28 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000014 141.0
PYH2_k127_488842_29 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.000000000000000000000000000000005929 133.0
PYH2_k127_488842_3 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 600.0
PYH2_k127_488842_30 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000004028 127.0
PYH2_k127_488842_31 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000009534 104.0
PYH2_k127_488842_32 Ferredoxin K05337 - - 0.0000000000000001869 81.0
PYH2_k127_488842_4 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 597.0
PYH2_k127_488842_5 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 590.0
PYH2_k127_488842_6 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 567.0
PYH2_k127_488842_7 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 544.0
PYH2_k127_488842_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 473.0
PYH2_k127_488842_9 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 469.0
PYH2_k127_5064232_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1349.0
PYH2_k127_5064232_1 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 5.197e-251 779.0
PYH2_k127_5064232_10 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 454.0
PYH2_k127_5064232_11 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 441.0
PYH2_k127_5064232_12 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 419.0
PYH2_k127_5064232_13 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 415.0
PYH2_k127_5064232_14 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 385.0
PYH2_k127_5064232_15 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 374.0
PYH2_k127_5064232_16 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 371.0
PYH2_k127_5064232_17 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 354.0
PYH2_k127_5064232_18 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 347.0
PYH2_k127_5064232_19 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 344.0
PYH2_k127_5064232_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.553e-250 785.0
PYH2_k127_5064232_20 PFAM GTP-binding protein HSR1-related K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008403 343.0
PYH2_k127_5064232_21 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 344.0
PYH2_k127_5064232_22 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 341.0
PYH2_k127_5064232_23 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 340.0
PYH2_k127_5064232_24 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 321.0
PYH2_k127_5064232_25 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
PYH2_k127_5064232_26 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 287.0
PYH2_k127_5064232_27 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001721 274.0
PYH2_k127_5064232_28 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001026 264.0
PYH2_k127_5064232_29 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005659 262.0
PYH2_k127_5064232_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.067e-211 663.0
PYH2_k127_5064232_30 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004086 256.0
PYH2_k127_5064232_31 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001558 243.0
PYH2_k127_5064232_32 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000000000000000000000000000000000000000004829 243.0
PYH2_k127_5064232_33 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000001543 226.0
PYH2_k127_5064232_34 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000001303 221.0
PYH2_k127_5064232_35 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
PYH2_k127_5064232_36 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000001949 218.0
PYH2_k127_5064232_37 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000003889 204.0
PYH2_k127_5064232_38 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000005487 196.0
PYH2_k127_5064232_39 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000000062 176.0
PYH2_k127_5064232_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 7.142e-209 664.0
PYH2_k127_5064232_40 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000009174 170.0
PYH2_k127_5064232_41 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000001751 175.0
PYH2_k127_5064232_42 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000002324 134.0
PYH2_k127_5064232_43 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000000002881 130.0
PYH2_k127_5064232_44 - - - - 0.000000000000000000000000003183 112.0
PYH2_k127_5064232_45 - - - - 0.0000000000000000000000000141 110.0
PYH2_k127_5064232_46 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000003684 113.0
PYH2_k127_5064232_47 - - - - 0.00000000000000000000003639 106.0
PYH2_k127_5064232_48 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000007935 99.0
PYH2_k127_5064232_49 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000000008205 98.0
PYH2_k127_5064232_5 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 2.386e-196 633.0
PYH2_k127_5064232_50 - - - - 0.0000006168 54.0
PYH2_k127_5064232_6 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 604.0
PYH2_k127_5064232_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 568.0
PYH2_k127_5064232_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 485.0
PYH2_k127_5064232_9 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 464.0
PYH2_k127_5618260_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1050.0
PYH2_k127_5618260_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 5e-324 999.0
PYH2_k127_5618260_10 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 578.0
PYH2_k127_5618260_11 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 557.0
PYH2_k127_5618260_12 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 534.0
PYH2_k127_5618260_13 N-4 methylation of cytosine K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008716 527.0
PYH2_k127_5618260_14 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 524.0
PYH2_k127_5618260_15 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 500.0
PYH2_k127_5618260_16 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 464.0
PYH2_k127_5618260_17 by modhmm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 487.0
PYH2_k127_5618260_18 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 453.0
PYH2_k127_5618260_19 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 439.0
PYH2_k127_5618260_2 DEAD DEAH box helicase domain protein K03725 - - 3.754e-285 890.0
PYH2_k127_5618260_20 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008904 445.0
PYH2_k127_5618260_21 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 423.0
PYH2_k127_5618260_22 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 396.0
PYH2_k127_5618260_23 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 365.0
PYH2_k127_5618260_24 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004873 356.0
PYH2_k127_5618260_25 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 356.0
PYH2_k127_5618260_26 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007615 322.0
PYH2_k127_5618260_27 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 313.0
PYH2_k127_5618260_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 306.0
PYH2_k127_5618260_29 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 292.0
PYH2_k127_5618260_3 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 3.96e-245 767.0
PYH2_k127_5618260_30 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
PYH2_k127_5618260_31 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007871 283.0
PYH2_k127_5618260_32 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003067 251.0
PYH2_k127_5618260_33 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003164 242.0
PYH2_k127_5618260_34 ZPR1-related zinc finger protein K06874 - - 0.0000000000000000000000000000000000000000000000000000000000000000583 226.0
PYH2_k127_5618260_35 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000002454 221.0
PYH2_k127_5618260_36 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000001624 218.0
PYH2_k127_5618260_37 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN - - - 0.000000000000000000000000000000000000000000000000000000000128 209.0
PYH2_k127_5618260_38 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000001335 207.0
PYH2_k127_5618260_39 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000005274 182.0
PYH2_k127_5618260_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.883e-234 733.0
PYH2_k127_5618260_40 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000001068 182.0
PYH2_k127_5618260_41 - - - - 0.00000000000000000000000000000000000000000000000002218 183.0
PYH2_k127_5618260_42 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000398 171.0
PYH2_k127_5618260_43 cell adhesion involved in biofilm formation K02453 - - 0.0000000000000000000000000000000000000000000001611 192.0
PYH2_k127_5618260_44 PFAM phosphatidate cytidylyltransferase - - - 0.00000000000000000000000000000000000000000001671 168.0
PYH2_k127_5618260_45 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000005019 163.0
PYH2_k127_5618260_46 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000000003572 155.0
PYH2_k127_5618260_47 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000531 155.0
PYH2_k127_5618260_48 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000000000000008374 145.0
PYH2_k127_5618260_49 Zinc-ribbon containing domain - - - 0.0000000000000000000000000000000001005 133.0
PYH2_k127_5618260_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.131e-231 722.0
PYH2_k127_5618260_50 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000007912 123.0
PYH2_k127_5618260_51 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.00000000000000000000000000001943 124.0
PYH2_k127_5618260_52 binds to the 23S rRNA K02922 - - 0.00000000000000000000000001916 108.0
PYH2_k127_5618260_53 chorismate mutase K04093 - 5.4.99.5 0.000000000000000000000000073 111.0
PYH2_k127_5618260_54 PBS lyase HEAT-like repeat - - - 0.000000000000000000000001212 106.0
PYH2_k127_5618260_55 membrane K09167 - - 0.000000000000000000000001751 109.0
PYH2_k127_5618260_56 - K00960 - 2.7.7.6 0.000000000000000000000006759 104.0
PYH2_k127_5618260_57 NADPH-dependent FMN reductase - - - 0.000000000000000002221 88.0
PYH2_k127_5618260_58 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000003342 76.0
PYH2_k127_5618260_59 Archaeal Type IV pilin, N-terminal - - - 0.0000000000003468 84.0
PYH2_k127_5618260_6 DEAD DEAH box helicase K03724 - - 6.622e-229 730.0
PYH2_k127_5618260_60 - - - - 0.0000000000007576 81.0
PYH2_k127_5618260_61 - - - - 0.00000000009234 76.0
PYH2_k127_5618260_62 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0001674 47.0
PYH2_k127_5618260_63 PFAM ABC-2 type transporter K01992 - - 0.0008835 45.0
PYH2_k127_5618260_7 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 1.271e-223 704.0
PYH2_k127_5618260_8 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.796e-210 658.0
PYH2_k127_5618260_9 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.829e-208 656.0
PYH2_k127_5955455_0 PFAM ribonuclease II K01147 - 3.1.13.1 1.06e-215 683.0
PYH2_k127_5955455_1 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 625.0
PYH2_k127_5955455_10 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000007043 149.0
PYH2_k127_5955455_11 integral membrane protein - - - 0.0000000000000000000000000000000006399 139.0
PYH2_k127_5955455_12 - - - - 0.000000000000000000000000005485 115.0
PYH2_k127_5955455_13 - - - - 0.0000000000000000000000002253 116.0
PYH2_k127_5955455_14 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000004112 91.0
PYH2_k127_5955455_15 - - - - 0.00000000000000000005867 89.0
PYH2_k127_5955455_16 Protein of unknown function (DUF998) - - - 0.00000000000003544 81.0
PYH2_k127_5955455_17 TfoX N-terminal domain - - - 0.000000000003152 71.0
PYH2_k127_5955455_18 - - - - 0.000002892 55.0
PYH2_k127_5955455_19 Rubrerythrin - - - 0.00006026 50.0
PYH2_k127_5955455_2 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 522.0
PYH2_k127_5955455_20 PFAM PKD domain containing protein - - - 0.0005687 47.0
PYH2_k127_5955455_3 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 406.0
PYH2_k127_5955455_4 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 353.0
PYH2_k127_5955455_5 Protein of unknown function (DUF3795) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 282.0
PYH2_k127_5955455_6 membrane K09167 - - 0.0000000000000000000000000000000000000000000000000000000000002185 216.0
PYH2_k127_5955455_7 PFAM Amidohydrolase 2 K07045 - - 0.00000000000000000000000000000000000000000000000000000000004557 215.0
PYH2_k127_5955455_8 COG1520 FOG WD40-like repeat - - - 0.00000000000000000000000000000000000000000000002392 184.0
PYH2_k127_5955455_9 - - - - 0.000000000000000000000000000000000000000004414 156.0
PYH2_k127_6242474_0 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 485.0
PYH2_k127_6242474_1 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000797 122.0
PYH2_k127_6267535_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1271.0
PYH2_k127_6267535_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 2.423e-306 946.0
PYH2_k127_6267535_10 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 531.0
PYH2_k127_6267535_11 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 481.0
PYH2_k127_6267535_12 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 473.0
PYH2_k127_6267535_13 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 460.0
PYH2_k127_6267535_14 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 456.0
PYH2_k127_6267535_15 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 436.0
PYH2_k127_6267535_16 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 429.0
PYH2_k127_6267535_17 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 403.0
PYH2_k127_6267535_18 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008655 405.0
PYH2_k127_6267535_19 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 398.0
PYH2_k127_6267535_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.307e-285 893.0
PYH2_k127_6267535_20 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 378.0
PYH2_k127_6267535_21 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 376.0
PYH2_k127_6267535_22 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 380.0
PYH2_k127_6267535_23 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 378.0
PYH2_k127_6267535_24 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 371.0
PYH2_k127_6267535_25 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 365.0
PYH2_k127_6267535_26 methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 347.0
PYH2_k127_6267535_27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 344.0
PYH2_k127_6267535_28 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 334.0
PYH2_k127_6267535_29 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 334.0
PYH2_k127_6267535_3 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 1.28e-247 773.0
PYH2_k127_6267535_30 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 339.0
PYH2_k127_6267535_31 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 328.0
PYH2_k127_6267535_32 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 329.0
PYH2_k127_6267535_33 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 302.0
PYH2_k127_6267535_34 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 288.0
PYH2_k127_6267535_35 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004426 281.0
PYH2_k127_6267535_36 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002859 270.0
PYH2_k127_6267535_37 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007149 268.0
PYH2_k127_6267535_38 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002468 259.0
PYH2_k127_6267535_39 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002047 262.0
PYH2_k127_6267535_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 1.105e-242 761.0
PYH2_k127_6267535_40 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003839 251.0
PYH2_k127_6267535_41 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000000000000000000000000000177 242.0
PYH2_k127_6267535_42 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000002853 235.0
PYH2_k127_6267535_43 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000000000000000000000000000000001144 224.0
PYH2_k127_6267535_44 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000002899 212.0
PYH2_k127_6267535_45 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000001914 207.0
PYH2_k127_6267535_46 - - - - 0.00000000000000000000000000000000000000000000000000000004337 205.0
PYH2_k127_6267535_47 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000004247 192.0
PYH2_k127_6267535_48 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000006442 190.0
PYH2_k127_6267535_49 Ras family K06945 - - 0.000000000000000000000000000000000000000000000009933 177.0
PYH2_k127_6267535_5 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 3.757e-240 747.0
PYH2_k127_6267535_50 Coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.00000000000000000000000000000000000000000000001024 178.0
PYH2_k127_6267535_51 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000474 151.0
PYH2_k127_6267535_52 PFAM PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000001104 149.0
PYH2_k127_6267535_53 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000001354 141.0
PYH2_k127_6267535_54 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000000000001711 139.0
PYH2_k127_6267535_55 protein conserved in archaea - - - 0.00000000000000000000000000000001247 129.0
PYH2_k127_6267535_56 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000000003698 123.0
PYH2_k127_6267535_57 Transcriptional regulator K07108 - - 0.000000000000000000000000000001001 124.0
PYH2_k127_6267535_58 transcriptional regulators K03724 - - 0.0000000000000000000000000003484 114.0
PYH2_k127_6267535_59 PFAM Yip1 domain - - - 0.000000000000000000000000004879 118.0
PYH2_k127_6267535_6 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 6.06e-224 699.0
PYH2_k127_6267535_60 PFAM Protein kinase domain - - - 0.000000000000000000000001042 115.0
PYH2_k127_6267535_61 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000000004577 98.0
PYH2_k127_6267535_62 - - - - 0.00000000000000000000005033 106.0
PYH2_k127_6267535_63 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000003582 94.0
PYH2_k127_6267535_64 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000005256 91.0
PYH2_k127_6267535_65 - - - - 0.00000000000000009004 81.0
PYH2_k127_6267535_66 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000004594 82.0
PYH2_k127_6267535_67 nucleic acid binding OB-fold tRNA helicase-type - - - 0.000000000000003404 80.0
PYH2_k127_6267535_68 - - - - 0.00000000002268 68.0
PYH2_k127_6267535_7 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 616.0
PYH2_k127_6267535_8 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 565.0
PYH2_k127_6267535_9 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 548.0
PYH2_k127_6377605_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006974 458.0
PYH2_k127_6377605_1 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 419.0
PYH2_k127_6377605_2 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.00000000000000000000000006265 108.0
PYH2_k127_6377605_3 Ribonuclease K03469 - 3.1.26.4 0.0000000000000000000000004407 113.0
PYH2_k127_6549200_0 - - - - 0.00000000000000000000000000000000000002545 161.0
PYH2_k127_6549200_1 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.000000000000000000000000000000000005705 141.0
PYH2_k127_6549200_2 Outer membrane receptor - - - 0.000000003251 69.0
PYH2_k127_6554173_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.957e-298 923.0
PYH2_k127_6554173_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.453e-259 804.0
PYH2_k127_6554173_10 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 453.0
PYH2_k127_6554173_11 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 450.0
PYH2_k127_6554173_12 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 425.0
PYH2_k127_6554173_13 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 417.0
PYH2_k127_6554173_14 Mitochondrial small ribosomal subunit Rsm22 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 398.0
PYH2_k127_6554173_15 Branched-chain amino acid transport system permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 385.0
PYH2_k127_6554173_16 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 381.0
PYH2_k127_6554173_17 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 375.0
PYH2_k127_6554173_18 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 360.0
PYH2_k127_6554173_19 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 354.0
PYH2_k127_6554173_2 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 8.174e-255 803.0
PYH2_k127_6554173_20 V-type ATP synthase, subunit I K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 350.0
PYH2_k127_6554173_21 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 322.0
PYH2_k127_6554173_22 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 321.0
PYH2_k127_6554173_23 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 306.0
PYH2_k127_6554173_24 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 308.0
PYH2_k127_6554173_25 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 307.0
PYH2_k127_6554173_26 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 299.0
PYH2_k127_6554173_27 FHA domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 294.0
PYH2_k127_6554173_28 archaeosine synthase activity K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 286.0
PYH2_k127_6554173_29 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000003974 290.0
PYH2_k127_6554173_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.437e-245 769.0
PYH2_k127_6554173_30 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009379 262.0
PYH2_k127_6554173_31 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004171 241.0
PYH2_k127_6554173_32 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000004855 231.0
PYH2_k127_6554173_33 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000000000000002234 242.0
PYH2_k127_6554173_34 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000006552 214.0
PYH2_k127_6554173_35 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000001242 192.0
PYH2_k127_6554173_36 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000002668 184.0
PYH2_k127_6554173_37 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000008925 188.0
PYH2_k127_6554173_38 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000000000000001654 175.0
PYH2_k127_6554173_39 ATP synthase subunit K K02124 - - 0.00000000000000000000000000000000000000000001906 165.0
PYH2_k127_6554173_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 6.95e-210 659.0
PYH2_k127_6554173_40 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000003355 162.0
PYH2_k127_6554173_41 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000197 138.0
PYH2_k127_6554173_42 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000001981 119.0
PYH2_k127_6554173_43 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000005773 109.0
PYH2_k127_6554173_44 ATP synthase subunit C K02124 - - 0.00000000000000000000007405 99.0
PYH2_k127_6554173_45 ATP synthase subunit C K02124 - - 0.00000000000000000000653 94.0
PYH2_k127_6554173_46 Protein of unknown function (DUF2764) - - - 0.000000000000000000007119 98.0
PYH2_k127_6554173_47 - - - - 0.0000000000000002463 87.0
PYH2_k127_6554173_49 PFAM Protein kinase domain - - - 0.000000000000007394 83.0
PYH2_k127_6554173_5 V-type ATPase 116kDa subunit family K02123 - - 9.022e-199 638.0
PYH2_k127_6554173_50 membrane transporter protein K07090 - - 0.00000000000003602 79.0
PYH2_k127_6554173_52 membrane transporter protein K07090 - - 0.00000000001156 69.0
PYH2_k127_6554173_53 S-layer homology domain - - - 0.00000001008 69.0
PYH2_k127_6554173_54 Tetratricopeptide repeat - - - 0.0000001422 54.0
PYH2_k127_6554173_55 helicase C-terminal domain protein - - - 0.0000002585 61.0
PYH2_k127_6554173_56 H subunit K02107 - - 0.0000264 51.0
PYH2_k127_6554173_6 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 6.212e-197 623.0
PYH2_k127_6554173_7 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 556.0
PYH2_k127_6554173_8 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 553.0
PYH2_k127_6554173_9 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 459.0
PYH2_k127_6629130_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 425.0
PYH2_k127_6629130_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 350.0
PYH2_k127_6629130_2 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 320.0
PYH2_k127_6629130_3 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 287.0
PYH2_k127_6629130_4 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002324 250.0
PYH2_k127_6629130_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000001136 103.0
PYH2_k127_6675280_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1020.0
PYH2_k127_6675280_1 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 356.0
PYH2_k127_6675280_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003261 244.0
PYH2_k127_6675280_3 HEAT repeats - - - 0.000000000000000000000000000000007541 133.0
PYH2_k127_6675280_4 Beta-propeller repeat - - - 0.000000000000000000000000000003522 123.0
PYH2_k127_6713528_0 KH, type 1, domain K07041 - - 0.0 1133.0
PYH2_k127_6713528_1 in RNase L inhibitor, RLI K06174 - - 7.161e-302 933.0
PYH2_k127_6713528_10 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 394.0
PYH2_k127_6713528_11 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 386.0
PYH2_k127_6713528_12 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
PYH2_k127_6713528_13 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 311.0
PYH2_k127_6713528_14 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 298.0
PYH2_k127_6713528_15 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 296.0
PYH2_k127_6713528_16 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 286.0
PYH2_k127_6713528_17 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000002154 248.0
PYH2_k127_6713528_18 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000001446 231.0
PYH2_k127_6713528_19 Zinc-uptake complex component A periplasmic K09815 - - 0.000000000000000000000000000000000000000000000000000000000000008804 226.0
PYH2_k127_6713528_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.044e-240 761.0
PYH2_k127_6713528_20 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000417 218.0
PYH2_k127_6713528_21 CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000219 213.0
PYH2_k127_6713528_22 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000001245 199.0
PYH2_k127_6713528_23 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000006073 190.0
PYH2_k127_6713528_24 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000001518 172.0
PYH2_k127_6713528_25 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.000000000000000000000000000000000000000000001158 169.0
PYH2_k127_6713528_26 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000002205 166.0
PYH2_k127_6713528_27 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000008047 164.0
PYH2_k127_6713528_28 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000002291 164.0
PYH2_k127_6713528_29 - - - - 0.0000000000000000000000000000003211 126.0
PYH2_k127_6713528_3 Domain of unknown function (DUF814) - - - 4.126e-217 691.0
PYH2_k127_6713528_30 RNase L inhibitor, RLI - - - 0.0000000000000000000000001692 109.0
PYH2_k127_6713528_31 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000002438 74.0
PYH2_k127_6713528_32 - - - - 0.00000000000003306 78.0
PYH2_k127_6713528_33 but it may be involved in stabilization of the trimeric complex - - - 0.0000000000007957 69.0
PYH2_k127_6713528_34 - K06193 - - 0.0000000001906 64.0
PYH2_k127_6713528_35 PKD domain containing protein - - - 0.000000000709 72.0
PYH2_k127_6713528_4 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 528.0
PYH2_k127_6713528_5 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007337 524.0
PYH2_k127_6713528_6 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 450.0
PYH2_k127_6713528_7 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 441.0
PYH2_k127_6713528_8 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 440.0
PYH2_k127_6713528_9 extracellular matrix structural constituent K01385 - 3.4.23.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 425.0
PYH2_k127_6726253_0 acid binding OB-fold tRNA helicase-type K07463 - - 2.18e-318 982.0
PYH2_k127_6726253_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 6.773e-299 936.0
PYH2_k127_6726253_10 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 526.0
PYH2_k127_6726253_11 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 522.0
PYH2_k127_6726253_12 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 493.0
PYH2_k127_6726253_13 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 460.0
PYH2_k127_6726253_14 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 458.0
PYH2_k127_6726253_15 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 449.0
PYH2_k127_6726253_16 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
PYH2_k127_6726253_17 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 364.0
PYH2_k127_6726253_18 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 357.0
PYH2_k127_6726253_19 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 338.0
PYH2_k127_6726253_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.27e-246 765.0
PYH2_k127_6726253_20 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 342.0
PYH2_k127_6726253_21 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 309.0
PYH2_k127_6726253_22 PFAM ADP-ribosylation Crystallin J1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 292.0
PYH2_k127_6726253_23 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000127 254.0
PYH2_k127_6726253_24 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000102 244.0
PYH2_k127_6726253_25 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000001246 230.0
PYH2_k127_6726253_26 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000000002884 214.0
PYH2_k127_6726253_27 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000201 212.0
PYH2_k127_6726253_28 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000000001225 186.0
PYH2_k127_6726253_29 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000000000000003847 186.0
PYH2_k127_6726253_3 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 1.459e-235 739.0
PYH2_k127_6726253_30 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000000000000000002536 179.0
PYH2_k127_6726253_31 B-block binding subunit of TFIIIC - - - 0.00000000000000000000000000000000000000000000001226 174.0
PYH2_k127_6726253_32 PFAM Yip1 domain - - - 0.000000000000000000000000000000000002472 145.0
PYH2_k127_6726253_33 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000000002832 135.0
PYH2_k127_6726253_34 - - - - 0.0000000000000000000000000000000001836 134.0
PYH2_k127_6726253_35 TfuA-like protein - - - 0.0000000000000000000000000000000009748 139.0
PYH2_k127_6726253_36 metal-binding protein - - - 0.0000000000000000000000000001148 117.0
PYH2_k127_6726253_37 COG0237 Dephospho-CoA kinase - - - 0.00000000000000000000004324 106.0
PYH2_k127_6726253_38 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000001421 101.0
PYH2_k127_6726253_39 - - - - 0.0000000000000000000001919 99.0
PYH2_k127_6726253_4 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 6.324e-206 644.0
PYH2_k127_6726253_40 PFAM Ribosomal protein S27E K02978 - - 0.000000000000000000007235 97.0
PYH2_k127_6726253_41 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000003447 76.0
PYH2_k127_6726253_42 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.00000000001283 68.0
PYH2_k127_6726253_43 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000001565 58.0
PYH2_k127_6726253_44 TPR repeat - - - 0.000001676 59.0
PYH2_k127_6726253_45 - - - - 0.0001293 53.0
PYH2_k127_6726253_46 - - - - 0.0005491 44.0
PYH2_k127_6726253_5 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 585.0
PYH2_k127_6726253_6 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008355 583.0
PYH2_k127_6726253_7 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 587.0
PYH2_k127_6726253_8 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 562.0
PYH2_k127_6726253_9 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 556.0
PYH2_k127_6731477_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1217.0
PYH2_k127_6731477_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1182.0
PYH2_k127_6988334_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1720.0
PYH2_k127_6988334_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1489.0
PYH2_k127_6988334_10 PFAM PUA domain containing protein K07557 - 2.6.1.97 5.428e-201 640.0
PYH2_k127_6988334_11 LOR SDH bifunctional enzyme conserved - - - 2.347e-198 627.0
PYH2_k127_6988334_12 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 5.64e-197 627.0
PYH2_k127_6988334_13 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 614.0
PYH2_k127_6988334_14 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 609.0
PYH2_k127_6988334_15 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 591.0
PYH2_k127_6988334_16 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 570.0
PYH2_k127_6988334_17 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 535.0
PYH2_k127_6988334_18 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 535.0
PYH2_k127_6988334_19 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 534.0
PYH2_k127_6988334_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 4.685e-316 978.0
PYH2_k127_6988334_20 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 518.0
PYH2_k127_6988334_21 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 505.0
PYH2_k127_6988334_22 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 472.0
PYH2_k127_6988334_23 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 471.0
PYH2_k127_6988334_24 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 459.0
PYH2_k127_6988334_25 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 449.0
PYH2_k127_6988334_26 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 450.0
PYH2_k127_6988334_27 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 448.0
PYH2_k127_6988334_28 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 445.0
PYH2_k127_6988334_29 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 443.0
PYH2_k127_6988334_3 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 1.487e-273 856.0
PYH2_k127_6988334_30 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 435.0
PYH2_k127_6988334_31 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 435.0
PYH2_k127_6988334_32 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 425.0
PYH2_k127_6988334_33 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 428.0
PYH2_k127_6988334_34 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 416.0
PYH2_k127_6988334_35 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 416.0
PYH2_k127_6988334_36 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009156 400.0
PYH2_k127_6988334_37 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 383.0
PYH2_k127_6988334_38 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 375.0
PYH2_k127_6988334_39 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
PYH2_k127_6988334_4 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 2.03e-235 737.0
PYH2_k127_6988334_40 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 365.0
PYH2_k127_6988334_41 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 359.0
PYH2_k127_6988334_42 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 354.0
PYH2_k127_6988334_43 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 349.0
PYH2_k127_6988334_44 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 329.0
PYH2_k127_6988334_45 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
PYH2_k127_6988334_46 40-residue YVTN family beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 349.0
PYH2_k127_6988334_47 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 307.0
PYH2_k127_6988334_48 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 306.0
PYH2_k127_6988334_49 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 307.0
PYH2_k127_6988334_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.71e-209 655.0
PYH2_k127_6988334_50 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 301.0
PYH2_k127_6988334_51 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 299.0
PYH2_k127_6988334_52 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007501 274.0
PYH2_k127_6988334_53 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001423 269.0
PYH2_k127_6988334_54 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000004946 266.0
PYH2_k127_6988334_55 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000002642 263.0
PYH2_k127_6988334_56 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001578 265.0
PYH2_k127_6988334_57 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006957 249.0
PYH2_k127_6988334_58 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000006352 243.0
PYH2_k127_6988334_59 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000000000065 235.0
PYH2_k127_6988334_6 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.595e-208 661.0
PYH2_k127_6988334_60 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000001425 221.0
PYH2_k127_6988334_61 - - - - 0.0000000000000000000000000000000000000000000000000000000000003487 214.0
PYH2_k127_6988334_62 - - - - 0.0000000000000000000000000000000000000000000000000000000000005637 224.0
PYH2_k127_6988334_63 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000007703 215.0
PYH2_k127_6988334_64 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000001087 215.0
PYH2_k127_6988334_65 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000005482 188.0
PYH2_k127_6988334_66 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000000000003156 183.0
PYH2_k127_6988334_67 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000001663 180.0
PYH2_k127_6988334_68 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000002106 176.0
PYH2_k127_6988334_69 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000006349 165.0
PYH2_k127_6988334_7 PFAM peptidase U32 K08303 - - 1.422e-207 675.0
PYH2_k127_6988334_70 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000007562 161.0
PYH2_k127_6988334_71 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000004194 155.0
PYH2_k127_6988334_72 - - - - 0.00000000000000000000000000000000000000003707 156.0
PYH2_k127_6988334_73 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000001206 142.0
PYH2_k127_6988334_74 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000000000000004834 134.0
PYH2_k127_6988334_75 - - - - 0.00000000000000000000000000000000008521 139.0
PYH2_k127_6988334_76 - - - - 0.0000000000000000000000000001203 118.0
PYH2_k127_6988334_77 transcription factor (CBF NF-Y) - - - 0.000000000000000000000001062 104.0
PYH2_k127_6988334_78 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000001309 101.0
PYH2_k127_6988334_79 - - - - 0.0000000000000000000003986 106.0
PYH2_k127_6988334_8 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 3.786e-207 649.0
PYH2_k127_6988334_80 signal transduction protein with CBS domains - - - 0.000000000000000000001087 105.0
PYH2_k127_6988334_81 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000001628 92.0
PYH2_k127_6988334_83 structural constituent of ribosome K02962 - - 0.0000000000000000001538 89.0
PYH2_k127_6988334_84 signal transduction protein with CBS domains - - - 0.000000000000000007141 94.0
PYH2_k127_6988334_85 - - - - 0.0000000000000000118 84.0
PYH2_k127_6988334_86 TIR domain - - - 0.00000000000000001864 87.0
PYH2_k127_6988334_87 - - - - 0.000000000000001389 79.0
PYH2_k127_6988334_88 - - - - 0.000000000001034 74.0
PYH2_k127_6988334_89 - - - - 0.00000000001161 66.0
PYH2_k127_6988334_9 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 4.534e-202 635.0
PYH2_k127_6988334_90 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00176 - 1.2.7.3 0.0000000002981 64.0
PYH2_k127_6988334_91 protein kinase activity - - - 0.00002267 55.0
PYH2_k127_6988334_92 - - - - 0.0002688 48.0
PYH2_k127_7526185_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0 1144.0
PYH2_k127_7526185_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1019.0
PYH2_k127_7526185_10 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 430.0
PYH2_k127_7526185_11 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 411.0
PYH2_k127_7526185_12 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 404.0
PYH2_k127_7526185_13 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 366.0
PYH2_k127_7526185_14 PFAM DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 358.0
PYH2_k127_7526185_15 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 309.0
PYH2_k127_7526185_16 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 297.0
PYH2_k127_7526185_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
PYH2_k127_7526185_18 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001353 277.0
PYH2_k127_7526185_19 Putative NAD(P)-binding K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001737 274.0
PYH2_k127_7526185_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.998e-213 666.0
PYH2_k127_7526185_20 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004063 276.0
PYH2_k127_7526185_21 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001142 268.0
PYH2_k127_7526185_22 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007983 259.0
PYH2_k127_7526185_23 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005352 262.0
PYH2_k127_7526185_24 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000002147 229.0
PYH2_k127_7526185_25 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000005135 238.0
PYH2_k127_7526185_26 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000009974 214.0
PYH2_k127_7526185_27 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000000000004744 211.0
PYH2_k127_7526185_28 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000003464 202.0
PYH2_k127_7526185_29 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000443 196.0
PYH2_k127_7526185_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 2.063e-199 634.0
PYH2_k127_7526185_30 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
PYH2_k127_7526185_31 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000002085 190.0
PYH2_k127_7526185_32 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000000000003656 184.0
PYH2_k127_7526185_33 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000003876 195.0
PYH2_k127_7526185_34 NLP P60 protein - - - 0.0000000000000000000000000000000000006837 147.0
PYH2_k127_7526185_35 Matrixin - - - 0.000000000000000000000000000000000001602 147.0
PYH2_k127_7526185_36 - - - - 0.000000000000000000000000000000000296 134.0
PYH2_k127_7526185_37 - - - - 0.00000000000000000000000000000005641 136.0
PYH2_k127_7526185_38 Flavodoxin - - - 0.0000000000000000000000000000002412 131.0
PYH2_k127_7526185_39 Mur ligase K01932 - - 0.0000000000000000000000000000004487 137.0
PYH2_k127_7526185_4 Bacterial protein of unknown function (DUF853) K06915 - - 3.255e-196 623.0
PYH2_k127_7526185_40 - - - - 0.0000000000000000000000000000004559 124.0
PYH2_k127_7526185_41 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000005663 123.0
PYH2_k127_7526185_42 - - - - 0.0000000000000000000000000003268 121.0
PYH2_k127_7526185_43 TIR domain - - - 0.0000000000000000000000007191 111.0
PYH2_k127_7526185_44 PFAM peptidase U32 K08303 - - 0.00000000000000000000299 96.0
PYH2_k127_7526185_45 - - - - 0.00000000000000004358 84.0
PYH2_k127_7526185_46 - - - - 0.00000000000000009397 91.0
PYH2_k127_7526185_47 Domain of unknown function (DUF4405) - - - 0.000000000000007886 81.0
PYH2_k127_7526185_48 - - - - 0.000000000002353 69.0
PYH2_k127_7526185_49 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000005084 78.0
PYH2_k127_7526185_5 Sulfatase K01130 - 3.1.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 569.0
PYH2_k127_7526185_50 - - - - 0.00000000003396 70.0
PYH2_k127_7526185_51 Capsule biosynthesis CapC - - - 0.00000000005485 70.0
PYH2_k127_7526185_52 CHY zinc finger K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000007375 70.0
PYH2_k127_7526185_55 Transposase DDE domain - - - 0.000001046 53.0
PYH2_k127_7526185_56 PFAM Uncharacterised conserved protein UCP006577 - - - 0.000008218 53.0
PYH2_k127_7526185_57 PFAM aminotransferase class V - - - 0.000008774 50.0
PYH2_k127_7526185_58 - - - - 0.00002242 48.0
PYH2_k127_7526185_59 Short repeat of unknown function (DUF308) - - - 0.0002032 51.0
PYH2_k127_7526185_6 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 559.0
PYH2_k127_7526185_7 PFAM phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 554.0
PYH2_k127_7526185_8 PFAM Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 563.0
PYH2_k127_7526185_9 Sulfate permease family K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 464.0
PYH2_k127_7614269_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 595.0
PYH2_k127_7614269_1 Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 478.0
PYH2_k127_7614269_2 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 420.0
PYH2_k127_7614269_3 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 303.0
PYH2_k127_7614269_5 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000000000003228 234.0
PYH2_k127_7614269_6 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000001027 94.0
PYH2_k127_7614269_7 Belongs to the UPF0248 family K09715 - - 0.0000000000000000003791 90.0
PYH2_k127_7614269_8 - - - - 0.0000000000000004892 80.0
PYH2_k127_7614269_9 SigmaK-factor processing regulatory protein BofA K06317 - - 0.0000002339 57.0
PYH2_k127_7620387_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1327.0
PYH2_k127_7620387_1 DEAD DEAH box helicase domain protein K10896 - - 2.696e-300 937.0
PYH2_k127_7620387_10 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 368.0
PYH2_k127_7620387_11 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 361.0
PYH2_k127_7620387_12 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 340.0
PYH2_k127_7620387_13 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 333.0
PYH2_k127_7620387_14 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 321.0
PYH2_k127_7620387_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 321.0
PYH2_k127_7620387_16 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 323.0
PYH2_k127_7620387_17 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 322.0
PYH2_k127_7620387_18 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002033 281.0
PYH2_k127_7620387_19 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002414 282.0
PYH2_k127_7620387_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 3.256e-280 872.0
PYH2_k127_7620387_20 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002879 272.0
PYH2_k127_7620387_21 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000007959 196.0
PYH2_k127_7620387_22 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000000000000000003165 175.0
PYH2_k127_7620387_23 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000000000000000007567 176.0
PYH2_k127_7620387_24 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000008118 168.0
PYH2_k127_7620387_25 - - - - 0.000000000000000000000000000000000000000000001553 169.0
PYH2_k127_7620387_26 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000003891 156.0
PYH2_k127_7620387_27 - - - - 0.00000000000000000000000000000000000004411 147.0
PYH2_k127_7620387_28 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000002056 142.0
PYH2_k127_7620387_29 Prokaryotic RING finger family 2 - - - 0.0000000000000000000000000004836 117.0
PYH2_k127_7620387_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.571e-217 693.0
PYH2_k127_7620387_30 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000004192 102.0
PYH2_k127_7620387_31 PDGLE domain K02009 - - 0.00000000000000000004299 102.0
PYH2_k127_7620387_32 - - - - 0.00000000000000000007179 91.0
PYH2_k127_7620387_33 - - - - 0.00000000000000000009725 94.0
PYH2_k127_7620387_34 - K02478 - 2.7.13.3 0.000000000000001474 80.0
PYH2_k127_7620387_35 - K02478 - 2.7.13.3 0.00000000000002892 75.0
PYH2_k127_7620387_36 defense response to virus K07061 - - 0.00000000004492 69.0
PYH2_k127_7620387_4 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 467.0
PYH2_k127_7620387_5 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 441.0
PYH2_k127_7620387_6 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 420.0
PYH2_k127_7620387_7 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 407.0
PYH2_k127_7620387_8 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 402.0
PYH2_k127_7620387_9 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 381.0
PYH2_k127_7781148_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 611.0
PYH2_k127_7781148_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 527.0
PYH2_k127_7781148_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004871 278.0
PYH2_k127_7781148_3 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000004172 184.0
PYH2_k127_7781148_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000000000000000000000000147 136.0
PYH2_k127_8181637_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1401.0
PYH2_k127_8181637_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1296.0
PYH2_k127_8181637_10 Highly conserved protein containing a thioredoxin domain K06888 - - 5.452e-209 671.0
PYH2_k127_8181637_100 Cupin domain - - - 0.0000000000000000000000000000000000000000000000007045 184.0
PYH2_k127_8181637_101 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.000000000000000000000000000000000000000000000005754 178.0
PYH2_k127_8181637_102 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.00000000000000000000000000000000000000000000002326 177.0
PYH2_k127_8181637_103 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000005517 174.0
PYH2_k127_8181637_104 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000000000003112 171.0
PYH2_k127_8181637_105 - - - - 0.00000000000000000000000000000000000000000001272 166.0
PYH2_k127_8181637_106 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000004093 161.0
PYH2_k127_8181637_107 - - - - 0.0000000000000000000000000000000000000000004095 166.0
PYH2_k127_8181637_108 - - - - 0.00000000000000000000000000000000000000004278 162.0
PYH2_k127_8181637_109 - - - - 0.0000000000000000000000000000000000000006704 151.0
PYH2_k127_8181637_11 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 7.536e-199 626.0
PYH2_k127_8181637_110 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000001099 154.0
PYH2_k127_8181637_111 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000000000000000001316 147.0
PYH2_k127_8181637_112 Hydrogenase maturation protease K08315 - 3.4.23.51 0.0000000000000000000000000000000000006542 147.0
PYH2_k127_8181637_113 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000007721 145.0
PYH2_k127_8181637_114 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000004319 149.0
PYH2_k127_8181637_115 Cobalamin biosynthesis protein CbiG K02189 - 3.7.1.12 0.0000000000000000000000000000000000368 145.0
PYH2_k127_8181637_116 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000003879 137.0
PYH2_k127_8181637_117 - - - - 0.00000000000000000000000000000000003886 147.0
PYH2_k127_8181637_118 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000000000000001501 136.0
PYH2_k127_8181637_119 zinc finger, SWIM - - - 0.000000000000000000000000000000006976 130.0
PYH2_k127_8181637_12 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 2.159e-198 632.0
PYH2_k127_8181637_120 small multi-drug export - - - 0.00000000000000000000000000000002132 133.0
PYH2_k127_8181637_121 - - - - 0.00000000000000000000000000000003915 131.0
PYH2_k127_8181637_122 - - - - 0.000000000000000000000000000001473 124.0
PYH2_k127_8181637_123 - - - - 0.00000000000000000000000000004224 124.0
PYH2_k127_8181637_124 Belongs to the small heat shock protein (HSP20) family - - - 0.000000000000000000000000001394 117.0
PYH2_k127_8181637_125 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000000001355 113.0
PYH2_k127_8181637_126 - - - - 0.00000000000000000000000001576 119.0
PYH2_k127_8181637_127 - - - - 0.00000000000000000000000002473 115.0
PYH2_k127_8181637_128 META domain - - - 0.00000000000000000000000005901 112.0
PYH2_k127_8181637_129 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.0000000000000000000000001584 109.0
PYH2_k127_8181637_13 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 6.406e-196 617.0
PYH2_k127_8181637_130 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000002832 108.0
PYH2_k127_8181637_131 - - - - 0.0000000000000000000000005132 115.0
PYH2_k127_8181637_132 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.0000000000000000000000008377 106.0
PYH2_k127_8181637_133 - - - - 0.000000000000000000000002585 104.0
PYH2_k127_8181637_134 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000007816 106.0
PYH2_k127_8181637_135 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000746 94.0
PYH2_k127_8181637_136 Domain of unknown function (DUF4040) - - - 0.0000000000000000000103 96.0
PYH2_k127_8181637_137 - - - - 0.0000000000000000009921 88.0
PYH2_k127_8181637_138 PFAM PKD domain containing protein - - - 0.000000000000000001789 96.0
PYH2_k127_8181637_139 PFAM Uncharacterised conserved protein UCP006577 - - - 0.00000000000000001965 85.0
PYH2_k127_8181637_14 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 1.638e-194 613.0
PYH2_k127_8181637_140 Membrane bound hydrogenase - - - 0.00000000000000034 81.0
PYH2_k127_8181637_142 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.00000000000001394 76.0
PYH2_k127_8181637_143 - - - - 0.0000000000000906 76.0
PYH2_k127_8181637_144 - - - - 0.0000009195 60.0
PYH2_k127_8181637_15 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 607.0
PYH2_k127_8181637_16 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 602.0
PYH2_k127_8181637_17 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 597.0
PYH2_k127_8181637_18 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 596.0
PYH2_k127_8181637_19 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 568.0
PYH2_k127_8181637_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1249.0
PYH2_k127_8181637_20 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 552.0
PYH2_k127_8181637_21 TGS domain protein K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 548.0
PYH2_k127_8181637_22 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 550.0
PYH2_k127_8181637_23 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 527.0
PYH2_k127_8181637_24 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 526.0
PYH2_k127_8181637_25 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007714 526.0
PYH2_k127_8181637_26 PFAM DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 511.0
PYH2_k127_8181637_27 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 498.0
PYH2_k127_8181637_28 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 460.0
PYH2_k127_8181637_29 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 430.0
PYH2_k127_8181637_3 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.289e-303 954.0
PYH2_k127_8181637_30 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 422.0
PYH2_k127_8181637_31 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 420.0
PYH2_k127_8181637_32 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 422.0
PYH2_k127_8181637_33 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 429.0
PYH2_k127_8181637_34 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 414.0
PYH2_k127_8181637_35 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 412.0
PYH2_k127_8181637_36 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 401.0
PYH2_k127_8181637_37 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 391.0
PYH2_k127_8181637_38 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 392.0
PYH2_k127_8181637_39 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 368.0
PYH2_k127_8181637_4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.722e-271 842.0
PYH2_k127_8181637_40 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 366.0
PYH2_k127_8181637_41 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 364.0
PYH2_k127_8181637_42 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009152 352.0
PYH2_k127_8181637_43 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 340.0
PYH2_k127_8181637_44 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 343.0
PYH2_k127_8181637_45 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 353.0
PYH2_k127_8181637_46 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 338.0
PYH2_k127_8181637_47 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 331.0
PYH2_k127_8181637_48 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 322.0
PYH2_k127_8181637_49 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 328.0
PYH2_k127_8181637_5 amino acid K03294 - - 1.291e-266 836.0
PYH2_k127_8181637_50 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 320.0
PYH2_k127_8181637_51 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 311.0
PYH2_k127_8181637_52 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 297.0
PYH2_k127_8181637_53 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 308.0
PYH2_k127_8181637_54 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 294.0
PYH2_k127_8181637_55 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 305.0
PYH2_k127_8181637_56 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 288.0
PYH2_k127_8181637_57 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008881 282.0
PYH2_k127_8181637_58 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000216 272.0
PYH2_k127_8181637_59 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007238 274.0
PYH2_k127_8181637_6 PFAM CBS domain - - - 1.405e-250 780.0
PYH2_k127_8181637_60 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004161 274.0
PYH2_k127_8181637_61 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001053 272.0
PYH2_k127_8181637_62 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001084 270.0
PYH2_k127_8181637_63 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007849 268.0
PYH2_k127_8181637_64 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001714 268.0
PYH2_k127_8181637_65 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000001006 265.0
PYH2_k127_8181637_66 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000016 259.0
PYH2_k127_8181637_67 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000000002178 256.0
PYH2_k127_8181637_68 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000005169 255.0
PYH2_k127_8181637_69 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18023 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002319 249.0
PYH2_k127_8181637_7 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 2.873e-250 783.0
PYH2_k127_8181637_70 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003768 248.0
PYH2_k127_8181637_71 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001529 249.0
PYH2_k127_8181637_72 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004558 241.0
PYH2_k127_8181637_73 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000001277 244.0
PYH2_k127_8181637_74 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002397 241.0
PYH2_k127_8181637_75 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000004489 242.0
PYH2_k127_8181637_76 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000000000001175 236.0
PYH2_k127_8181637_77 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000001057 231.0
PYH2_k127_8181637_78 PFAM Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000103 238.0
PYH2_k127_8181637_79 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000000001611 226.0
PYH2_k127_8181637_8 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 7.818e-228 713.0
PYH2_k127_8181637_80 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000003122 226.0
PYH2_k127_8181637_81 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000006301 222.0
PYH2_k127_8181637_82 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000000000002584 216.0
PYH2_k127_8181637_83 archaeal Zn-finger protein - - - 0.000000000000000000000000000000000000000000000000000000000003136 214.0
PYH2_k127_8181637_84 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.000000000000000000000000000000000000000000000000000000000004118 214.0
PYH2_k127_8181637_85 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000000000000008674 207.0
PYH2_k127_8181637_86 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.000000000000000000000000000000000000000000000000000000002271 205.0
PYH2_k127_8181637_87 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.000000000000000000000000000000000000000000000000000000006604 200.0
PYH2_k127_8181637_88 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000002299 200.0
PYH2_k127_8181637_89 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000318 207.0
PYH2_k127_8181637_9 Proton-conducting membrane transporter K05568 - - 1.62e-224 706.0
PYH2_k127_8181637_90 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000006969 196.0
PYH2_k127_8181637_91 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000007272 193.0
PYH2_k127_8181637_92 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000002298 196.0
PYH2_k127_8181637_93 Small multi-drug export protein - - - 0.0000000000000000000000000000000000000000000000000001017 194.0
PYH2_k127_8181637_94 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000001122 184.0
PYH2_k127_8181637_95 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000000000000000000000000002347 184.0
PYH2_k127_8181637_96 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000004783 182.0
PYH2_k127_8181637_97 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000001346 189.0
PYH2_k127_8181637_98 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000201 179.0
PYH2_k127_8181637_99 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000641 179.0
PYH2_k127_8640115_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1084.0
PYH2_k127_8640115_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.915e-237 758.0
PYH2_k127_8640115_10 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000003493 224.0
PYH2_k127_8640115_11 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000127 166.0
PYH2_k127_8640115_12 peptide deformylase activity K01462 - 3.5.1.88 0.00000000000000000000000000009984 123.0
PYH2_k127_8640115_13 - - - - 0.0000000000000000000000000006728 123.0
PYH2_k127_8640115_14 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000000000003094 108.0
PYH2_k127_8640115_15 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000000000000003827 91.0
PYH2_k127_8640115_16 Protein of unknown function (DUF2769) - - - 0.000000000000000001545 94.0
PYH2_k127_8640115_17 - - - - 0.00000000000001863 74.0
PYH2_k127_8640115_18 PFAM YHS domain - - - 0.00000000001573 72.0
PYH2_k127_8640115_2 Belongs to the glutamate synthase family - - - 1.766e-219 691.0
PYH2_k127_8640115_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 452.0
PYH2_k127_8640115_4 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 420.0
PYH2_k127_8640115_5 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 384.0
PYH2_k127_8640115_6 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 350.0
PYH2_k127_8640115_7 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 345.0
PYH2_k127_8640115_8 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 332.0
PYH2_k127_8640115_9 PFAM Ferritin, Dps family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 317.0
PYH2_k127_8693376_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007853 565.0
PYH2_k127_8693376_1 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 511.0
PYH2_k127_8693376_10 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 388.0
PYH2_k127_8693376_11 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 301.0
PYH2_k127_8693376_12 Met-10+ like-protein K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 273.0
PYH2_k127_8693376_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002829 275.0
PYH2_k127_8693376_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001652 270.0
PYH2_k127_8693376_15 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006317 247.0
PYH2_k127_8693376_16 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000023 186.0
PYH2_k127_8693376_17 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000002378 164.0
PYH2_k127_8693376_18 - - - - 0.00000000000000000000000000837 114.0
PYH2_k127_8693376_19 Regulatory protein MarR - - - 0.00000000000000000000000001782 113.0
PYH2_k127_8693376_2 Pas domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 513.0
PYH2_k127_8693376_20 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000001346 105.0
PYH2_k127_8693376_21 PspC domain K03973 - - 0.0000000000000000006473 88.0
PYH2_k127_8693376_22 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000002269 89.0
PYH2_k127_8693376_23 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000003936 91.0
PYH2_k127_8693376_24 Ion channel - - - 0.000000000000001602 89.0
PYH2_k127_8693376_25 - - - - 0.000000000000001822 79.0
PYH2_k127_8693376_26 - - - - 0.0000000000001343 81.0
PYH2_k127_8693376_27 TIR domain - - - 0.000000000005337 72.0
PYH2_k127_8693376_28 PFAM TPR repeat-containing protein - - - 0.00000000001109 71.0
PYH2_k127_8693376_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 463.0
PYH2_k127_8693376_30 deoxyhypusine monooxygenase activity K06921 - - 0.00001543 53.0
PYH2_k127_8693376_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 445.0
PYH2_k127_8693376_5 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 435.0
PYH2_k127_8693376_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 426.0
PYH2_k127_8693376_7 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 424.0
PYH2_k127_8693376_8 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 409.0
PYH2_k127_8693376_9 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 385.0
PYH2_k127_8818818_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.675e-243 760.0
PYH2_k127_8818818_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 3.561e-205 651.0
PYH2_k127_8818818_10 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000000000001225 152.0
PYH2_k127_8818818_11 PFAM PUA domain containing protein K07398 - - 0.0000000000000000000000000000000000000009418 153.0
PYH2_k127_8818818_12 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000003893 149.0
PYH2_k127_8818818_13 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000001429 162.0
PYH2_k127_8818818_14 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000000005393 122.0
PYH2_k127_8818818_15 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000000000001501 97.0
PYH2_k127_8818818_16 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000002654 89.0
PYH2_k127_8818818_17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000003878 89.0
PYH2_k127_8818818_18 Belongs to the peptidase S8 family - - - 0.000000004634 71.0
PYH2_k127_8818818_19 PhoD-like phosphatase K01113 - 3.1.3.1 0.00001024 57.0
PYH2_k127_8818818_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 598.0
PYH2_k127_8818818_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009198 417.0
PYH2_k127_8818818_4 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 355.0
PYH2_k127_8818818_5 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007184 316.0
PYH2_k127_8818818_6 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 307.0
PYH2_k127_8818818_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000006544 213.0
PYH2_k127_8818818_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000000002445 195.0
PYH2_k127_8818818_9 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000007945 155.0
PYH2_k127_942944_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 4.958e-197 620.0
PYH2_k127_942944_1 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 560.0
PYH2_k127_942944_2 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 500.0
PYH2_k127_942944_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004988 482.0
PYH2_k127_942944_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 293.0
PYH2_k127_942944_5 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000545 284.0
PYH2_k127_942944_7 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000001535 145.0
PYH2_k127_942944_9 PFAM NHL repeat containing protein - - - 0.00000000000002013 76.0