logo

Overview

ID MAG03191
Name PYH2_bin.41
Sample SMP0074
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Thermodesulfovibrionia
Order Thermodesulfovibrionales
Family UBA6898
Genus
Species
Assembly information
Completeness (%) 94.44
Contamination (%) 0.56
GC content (%) 59.0
N50 (bp) 9,331
Genome size (bp) 2,075,527

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2036

Gene name Description KEGG GOs EC E-value Score Sequence
PYH2_k127_1029428_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 1.391e-201 632.0
PYH2_k127_1029428_1 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 611.0
PYH2_k127_1029428_10 Chemotaxis sensory transducer K03406 - - 0.00000000000000000001406 93.0
PYH2_k127_1029428_2 PFAM Class II aldolase K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 336.0
PYH2_k127_1029428_3 S-methyl-5'-thioadenosine phosphorylase K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004645,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0010033,GO:0016053,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017061,GO:0017144,GO:0019221,GO:0019509,GO:0019752,GO:0023052,GO:0032259,GO:0034097,GO:0034641,GO:0035722,GO:0042221,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070671,GO:0070887,GO:0071265,GO:0071267,GO:0071310,GO:0071345,GO:0071349,GO:0071704,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 320.0
PYH2_k127_1029428_4 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 317.0
PYH2_k127_1029428_5 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009286 298.0
PYH2_k127_1029428_6 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 289.0
PYH2_k127_1029428_7 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000004058 227.0
PYH2_k127_1029428_8 PFAM SEC-C motif K09858 - - 0.00000000000000000000000000000000000000000000000000000000004568 210.0
PYH2_k127_1029428_9 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000001616 173.0
PYH2_k127_103502_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 2.308e-218 691.0
PYH2_k127_1055727_0 Endoribonuclease that initiates mRNA decay K18682 - - 8.576e-203 644.0
PYH2_k127_1055727_1 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 446.0
PYH2_k127_1055727_2 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006896 412.0
PYH2_k127_1055727_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 327.0
PYH2_k127_1055727_4 YmdB-like protein K09769 - - 0.000000000000000000000000000000000000000000001674 168.0
PYH2_k127_1055727_5 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000003337 118.0
PYH2_k127_1055727_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000002098 89.0
PYH2_k127_1067156_0 ferrous iron transmembrane transporter activity K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 429.0
PYH2_k127_1067156_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 307.0
PYH2_k127_1068847_0 RDD family - - - 0.0000000000000000000000000000000000000000000000000000000006895 214.0
PYH2_k127_1068847_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000008463 181.0
PYH2_k127_1068847_2 - - - - 0.000000000000000000000000000000000000000008075 162.0
PYH2_k127_1068847_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000001105 115.0
PYH2_k127_1068847_4 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000002689 76.0
PYH2_k127_1068847_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.00000000000009916 79.0
PYH2_k127_1068847_6 - - - - 0.0000000000001153 83.0
PYH2_k127_1081356_0 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 369.0
PYH2_k127_1081356_1 Putative Fe-S cluster K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 332.0
PYH2_k127_1081356_2 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 282.0
PYH2_k127_1081356_3 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000001266 238.0
PYH2_k127_1081356_4 Part of a membrane complex involved in electron transport K03613 - - 0.0000000000000000000000000000000000000000000000000000005041 200.0
PYH2_k127_1081356_5 Part of a membrane complex involved in electron transport K03612 - - 0.0000000000000000000000004694 113.0
PYH2_k127_1111731_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 460.0
PYH2_k127_1111731_1 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 428.0
PYH2_k127_1111731_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 349.0
PYH2_k127_1111731_3 HemY domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 305.0
PYH2_k127_1188001_0 7TM receptor with intracellular HD hydrolase K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 478.0
PYH2_k127_1188001_1 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 397.0
PYH2_k127_1188001_2 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000000000000000000000000000000000000000000005378 198.0
PYH2_k127_1188001_3 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000001126 190.0
PYH2_k127_1188001_4 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K03474,K03595,K07042 GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 0.000000000000000000000000001444 119.0
PYH2_k127_1196857_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 353.0
PYH2_k127_1196857_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 343.0
PYH2_k127_1196857_11 - - - - 0.00003188 47.0
PYH2_k127_1196857_2 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 316.0
PYH2_k127_1196857_3 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 311.0
PYH2_k127_1196857_4 NosL - - - 0.00000000000000000000000000000000632 141.0
PYH2_k127_1196857_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000000008862 123.0
PYH2_k127_1196857_6 Thiamine-binding protein - - - 0.00000000000000000000000000165 115.0
PYH2_k127_1196857_7 PFAM Nitrate reductase gamma subunit - - - 0.0000000000000000000008182 104.0
PYH2_k127_1196857_8 Tetratricopeptide repeat - - - 0.0000000000000000395 91.0
PYH2_k127_1196857_9 CYTH domain K05873 - 4.6.1.1 0.000000000001158 76.0
PYH2_k127_1206454_0 PFAM binding-protein-dependent transport systems inner membrane component K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 417.0
PYH2_k127_1206454_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 407.0
PYH2_k127_1206454_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 306.0
PYH2_k127_1206454_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004531 248.0
PYH2_k127_1219615_0 FAD binding domain K00394 - 1.8.99.2 0.0 1037.0
PYH2_k127_1219615_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1018.0
PYH2_k127_1219615_2 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 7e-323 1002.0
PYH2_k127_1219615_3 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 567.0
PYH2_k127_1219615_4 FAD dependent oxidoreductase K16885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 557.0
PYH2_k127_1219615_5 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 396.0
PYH2_k127_1219615_6 Adenosine-5'-phosphosulfate reductase beta subunit K00395 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000004587 253.0
PYH2_k127_1248863_0 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 445.0
PYH2_k127_1248863_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 366.0
PYH2_k127_1248863_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 337.0
PYH2_k127_1248863_3 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 336.0
PYH2_k127_1248863_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005762 295.0
PYH2_k127_1248863_5 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
PYH2_k127_1248863_6 phosphorelay sensor kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000004495 229.0
PYH2_k127_1248863_7 response regulator K02485 - - 0.000000000000000000000000000000000000000000000007032 184.0
PYH2_k127_1248863_8 AsmA-like C-terminal region K07289 - - 0.00000000000000000000000000000006578 144.0
PYH2_k127_1248863_9 integral membrane protein - - - 0.00000004122 63.0
PYH2_k127_1249700_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 497.0
PYH2_k127_1249700_1 Polysaccharide export protein K01991 - - 0.0000000000000000000000000000000000000000212 164.0
PYH2_k127_1260707_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 549.0
PYH2_k127_1260707_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 404.0
PYH2_k127_1260707_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 321.0
PYH2_k127_1341731_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.206e-209 666.0
PYH2_k127_1341731_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 339.0
PYH2_k127_1341731_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000009195 232.0
PYH2_k127_1341731_3 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.0000000000000000000000000000007321 128.0
PYH2_k127_1341731_4 NusG domain II K00805 - 2.5.1.30 0.0000000000000000001091 93.0
PYH2_k127_1341731_5 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000007538 78.0
PYH2_k127_1486033_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1114.0
PYH2_k127_1486033_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.525e-230 715.0
PYH2_k127_1486033_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000002794 239.0
PYH2_k127_1486033_3 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000003736 202.0
PYH2_k127_1486033_4 molybdenum cofactor K03638,K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000006677 199.0
PYH2_k127_1486033_6 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000001969 69.0
PYH2_k127_1519863_0 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 488.0
PYH2_k127_1519863_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000002149 229.0
PYH2_k127_1519863_2 - - - - 0.00000000000000000000000000002746 121.0
PYH2_k127_1519863_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000006219 122.0
PYH2_k127_1519863_4 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000007909 110.0
PYH2_k127_1519863_5 - - - - 0.00000000001078 72.0
PYH2_k127_1519863_6 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00007202 54.0
PYH2_k127_1529837_0 Peptidase family M28 - - - 0.0 1039.0
PYH2_k127_1529837_1 Belongs to the peptidase S16 family K01338,K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 599.0
PYH2_k127_1529837_2 Beta Propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 549.0
PYH2_k127_1529837_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 368.0
PYH2_k127_1529837_4 - - - - 0.00000000000000000000000000000000000000000000000002018 183.0
PYH2_k127_1529837_5 Ribosomal RNA adenine dimethylase - - - 0.00000000002432 71.0
PYH2_k127_1553305_0 RNA polymerase beta subunit external 1 domain K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1604.0
PYH2_k127_1553305_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1498.0
PYH2_k127_1553305_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 304.0
PYH2_k127_1553305_3 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003431 261.0
PYH2_k127_1553305_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000796 212.0
PYH2_k127_1553305_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000007825 191.0
PYH2_k127_1553305_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000001114 142.0
PYH2_k127_1553305_7 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000002576 69.0
PYH2_k127_1572924_0 phosphate acetyltransferase K00625,K13788 - 2.3.1.8 1.001e-270 851.0
PYH2_k127_1572924_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 524.0
PYH2_k127_1572924_2 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000002232 196.0
PYH2_k127_1572924_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K09181,K15520 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 0.00000000000000000000000000000000000000000000006531 176.0
PYH2_k127_1574762_0 glycyl-tRNA synthetase, tetrameric type, beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 515.0
PYH2_k127_1574762_1 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 471.0
PYH2_k127_1574762_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 324.0
PYH2_k127_1665569_0 Elongation factor G, domain IV K02355 - - 2.096e-294 917.0
PYH2_k127_1665569_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000005497 253.0
PYH2_k127_1665569_2 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000000000000000000001617 162.0
PYH2_k127_1665569_3 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000001238 153.0
PYH2_k127_1665569_4 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000000000000008576 119.0
PYH2_k127_1665569_5 Membrane - - - 0.000000000000000000000002343 110.0
PYH2_k127_1665569_6 - - - - 0.0000000000000000000002633 97.0
PYH2_k127_1665569_7 Positive regulator of sigma(E), RseC/MucC K03803 - - 0.000000000000008431 82.0
PYH2_k127_1716432_0 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 477.0
PYH2_k127_1716432_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 424.0
PYH2_k127_1716432_2 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 374.0
PYH2_k127_1716432_3 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007177 254.0
PYH2_k127_1716432_4 regulatory protein ArsR K03892 - - 0.0000000000000000000000001621 109.0
PYH2_k127_1722419_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 523.0
PYH2_k127_1722419_1 CAAX prenyl protease N-terminal, five membrane helices - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 469.0
PYH2_k127_1722419_2 - - - - 0.000000001336 68.0
PYH2_k127_1722419_3 PFAM Outer membrane K06142 - - 0.000000003499 66.0
PYH2_k127_1728359_0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 506.0
PYH2_k127_1728359_1 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 292.0
PYH2_k127_1728359_2 TIGRFAM hydrolase, TatD family K03424 - - 0.00000000000000000000000000000000000000000000000002849 184.0
PYH2_k127_1728359_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000001075 169.0
PYH2_k127_173871_0 Telomere recombination K04656 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 489.0
PYH2_k127_173871_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 452.0
PYH2_k127_173871_2 Hydrogenase formation hypA family K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 445.0
PYH2_k127_173871_3 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 357.0
PYH2_k127_173871_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 308.0
PYH2_k127_173871_5 - - - - 0.0000000000000000001007 97.0
PYH2_k127_173871_6 PPIC-type PPIASE domain K03769,K07533 - 5.2.1.8 0.0000000000009265 79.0
PYH2_k127_180929_0 glucan 1,4-alpha-glucosidase activity - - - 2.419e-235 746.0
PYH2_k127_180929_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 323.0
PYH2_k127_180929_2 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 305.0
PYH2_k127_180929_3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.0000000000000000000000000000000000000000000000001747 185.0
PYH2_k127_180929_4 Hep Hag repeat protein - - - 0.00000000000003127 76.0
PYH2_k127_180929_5 LETM1-like protein - - - 0.00001248 53.0
PYH2_k127_1833482_0 AMP-binding enzyme C-terminal domain K05939 - 2.3.1.40,6.2.1.20 1.814e-198 631.0
PYH2_k127_1833482_1 PFAM AICARFT IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 1.523e-197 623.0
PYH2_k127_1833482_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000434 216.0
PYH2_k127_1833482_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001605 199.0
PYH2_k127_1833482_4 HD domain K07023 - - 0.00000000000000000000000000000000000000000000003148 172.0
PYH2_k127_1891279_0 Heat shock 70 kDa protein K04043 - - 7.4e-323 996.0
PYH2_k127_1891279_1 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 485.0
PYH2_k127_1891279_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 417.0
PYH2_k127_1891279_3 spermidine synthase activity K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 405.0
PYH2_k127_1891279_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 304.0
PYH2_k127_1891279_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000002823 162.0
PYH2_k127_1891279_6 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000005559 117.0
PYH2_k127_1891279_7 - - - - 0.000000000000000000001113 100.0
PYH2_k127_1944295_0 Ammonium Transporter K03320 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 472.0
PYH2_k127_1944295_1 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 367.0
PYH2_k127_1944295_2 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003903 293.0
PYH2_k127_1944295_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000007614 196.0
PYH2_k127_1944295_4 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000002286 181.0
PYH2_k127_1986700_0 N-Acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 460.0
PYH2_k127_1986700_1 Family 5 K02035,K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 363.0
PYH2_k127_1986700_10 iron-sulfur cluster assembly - - - 0.0000000000000000000003987 100.0
PYH2_k127_1986700_11 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16785 - - 0.00000000001153 73.0
PYH2_k127_1986700_2 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 342.0
PYH2_k127_1986700_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003792 282.0
PYH2_k127_1986700_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009747 263.0
PYH2_k127_1986700_5 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000001027 240.0
PYH2_k127_1986700_6 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000001311 237.0
PYH2_k127_1986700_7 B12 binding domain K04034 - 1.21.98.3 0.00000000000000000000000000000000000000001007 169.0
PYH2_k127_1986700_8 PFAM glutamine amidotransferase class-I K07010 - - 0.000000000000000000000000000000000002721 145.0
PYH2_k127_1986700_9 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000002745 131.0
PYH2_k127_1991456_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 426.0
PYH2_k127_1991456_1 thiosulfate sulfurtransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001021 261.0
PYH2_k127_1991456_2 PFAM Rhodanese domain protein - - - 0.00000000000000000000000000125 119.0
PYH2_k127_2015056_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1161.0
PYH2_k127_2015056_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 1.642e-242 764.0
PYH2_k127_2015056_10 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 361.0
PYH2_k127_2015056_11 Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 358.0
PYH2_k127_2015056_12 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 314.0
PYH2_k127_2015056_13 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000469 287.0
PYH2_k127_2015056_14 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008215 268.0
PYH2_k127_2015056_15 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000004468 213.0
PYH2_k127_2015056_16 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000006052 167.0
PYH2_k127_2015056_17 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000001564 151.0
PYH2_k127_2015056_18 GYD domain - - - 0.000000000000000000000000000000001865 133.0
PYH2_k127_2015056_19 Protein of unknown function, DUF485 - - - 0.00000000000000000000000003384 111.0
PYH2_k127_2015056_2 glycolate transport K14393 - - 2.685e-242 760.0
PYH2_k127_2015056_20 sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000002247 111.0
PYH2_k127_2015056_21 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000008442 101.0
PYH2_k127_2015056_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 1.794e-197 635.0
PYH2_k127_2015056_4 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 573.0
PYH2_k127_2015056_5 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 589.0
PYH2_k127_2015056_6 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 519.0
PYH2_k127_2015056_7 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 461.0
PYH2_k127_2015056_8 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 422.0
PYH2_k127_2015056_9 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 385.0
PYH2_k127_2029357_0 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 409.0
PYH2_k127_2029357_1 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 290.0
PYH2_k127_2029357_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 291.0
PYH2_k127_2029357_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 263.0
PYH2_k127_2029357_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000009495 224.0
PYH2_k127_2029357_5 OstA-like protein K09774 - - 0.00000000000000000000000000000000002935 140.0
PYH2_k127_2029357_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000007373 139.0
PYH2_k127_2029357_7 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000004638 96.0
PYH2_k127_2029357_8 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000004801 84.0
PYH2_k127_2029357_9 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0001812 44.0
PYH2_k127_2058020_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 612.0
PYH2_k127_2058020_1 Domain of unknown function (DUF3842) - - - 0.0000000000000000000000000000000000000000000000001841 186.0
PYH2_k127_2058020_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000001343 174.0
PYH2_k127_2058020_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.00000000000000000000000000000000000000001521 165.0
PYH2_k127_2058020_4 SdpI/YhfL protein family - - - 0.000000007617 62.0
PYH2_k127_2059735_0 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 542.0
PYH2_k127_2059735_1 FAD dependent oxidoreductase K15736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 526.0
PYH2_k127_2059735_10 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 326.0
PYH2_k127_2059735_11 metal-dependent enzyme K09153 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 306.0
PYH2_k127_2059735_12 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 313.0
PYH2_k127_2059735_13 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 327.0
PYH2_k127_2059735_14 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 292.0
PYH2_k127_2059735_15 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000008412 230.0
PYH2_k127_2059735_16 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000004182 229.0
PYH2_k127_2059735_17 CheR methyltransferase, all-alpha domain K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000004919 218.0
PYH2_k127_2059735_18 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000001833 205.0
PYH2_k127_2059735_19 PFAM CheW domain protein K03408 - - 0.0000000000000000000000000000000000007721 145.0
PYH2_k127_2059735_2 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 530.0
PYH2_k127_2059735_20 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000003172 149.0
PYH2_k127_2059735_21 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000008948 156.0
PYH2_k127_2059735_22 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000001722 135.0
PYH2_k127_2059735_23 TIGRFAM methyltransferase MtaA CmuA family K01599 - 4.1.1.37 0.00000000000000000000000000000005512 138.0
PYH2_k127_2059735_24 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000003206 130.0
PYH2_k127_2059735_25 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000286 114.0
PYH2_k127_2059735_26 cheY-homologous receiver domain - - - 0.00000000000000000000000002545 113.0
PYH2_k127_2059735_27 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000009449 115.0
PYH2_k127_2059735_28 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000003807 107.0
PYH2_k127_2059735_29 Response regulator receiver domain K03413 - - 0.00000000000000000000002603 110.0
PYH2_k127_2059735_3 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006486 523.0
PYH2_k127_2059735_30 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000004579 105.0
PYH2_k127_2059735_31 Chemoreceptor zinc-binding domain - - - 0.0000000000000000004133 91.0
PYH2_k127_2059735_32 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K07714 GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000003527 88.0
PYH2_k127_2059735_33 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000003203 74.0
PYH2_k127_2059735_34 Chemotaxis protein CheX K03409 - - 0.00000000005917 69.0
PYH2_k127_2059735_35 binding domain protein - - - 0.0000000008855 61.0
PYH2_k127_2059735_36 PFAM Uncharacterised protein family UPF0150 - - - 0.00004567 47.0
PYH2_k127_2059735_4 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 514.0
PYH2_k127_2059735_5 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 504.0
PYH2_k127_2059735_6 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006062 498.0
PYH2_k127_2059735_7 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 466.0
PYH2_k127_2059735_8 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 406.0
PYH2_k127_2059735_9 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 381.0
PYH2_k127_2085414_0 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 501.0
PYH2_k127_2085414_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 456.0
PYH2_k127_2085414_10 PFAM Major Facilitator Superfamily - - - 0.00000000001597 66.0
PYH2_k127_2085414_2 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 414.0
PYH2_k127_2085414_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 421.0
PYH2_k127_2085414_4 AAA domain, putative AbiEii toxin, Type IV TA system K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 323.0
PYH2_k127_2085414_5 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005567 282.0
PYH2_k127_2085414_6 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001648 259.0
PYH2_k127_2085414_7 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000004048 247.0
PYH2_k127_2085414_8 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000001654 189.0
PYH2_k127_2085414_9 Ferric uptake regulator family K03711 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000005225 90.0
PYH2_k127_2096867_0 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000001356 231.0
PYH2_k127_2096867_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000881 111.0
PYH2_k127_2096867_2 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000004937 101.0
PYH2_k127_2098457_0 Carbohydrate phosphorylase K00688,K00691 - 2.4.1.1,2.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 483.0
PYH2_k127_2098457_1 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.00000000000000000000000000001038 124.0
PYH2_k127_2098457_2 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.00000000000000000007866 91.0
PYH2_k127_2101048_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 611.0
PYH2_k127_2101048_1 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 445.0
PYH2_k127_2101048_10 SMART metal-dependent phosphohydrolase, HD region K06950 - - 0.00000000000000000000000000000000000000000958 154.0
PYH2_k127_2101048_11 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000001333 155.0
PYH2_k127_2101048_12 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000008463 152.0
PYH2_k127_2101048_13 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000388 125.0
PYH2_k127_2101048_14 Protein of unknown function (DUF507) - - - 0.000000000000000000000000005796 112.0
PYH2_k127_2101048_15 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000001617 107.0
PYH2_k127_2101048_16 Protein of unknown function (DUF507) - - - 0.0000000000000000000000306 104.0
PYH2_k127_2101048_2 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 421.0
PYH2_k127_2101048_3 Sigma-54 interaction domain K02481,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 426.0
PYH2_k127_2101048_4 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 386.0
PYH2_k127_2101048_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007661 280.0
PYH2_k127_2101048_6 Domain present in phytochromes and cGMP-specific phosphodiesterases. K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000004965 263.0
PYH2_k127_2101048_7 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000008372 240.0
PYH2_k127_2101048_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000002002 179.0
PYH2_k127_2101048_9 SMART HNH nuclease K07451 - - 0.000000000000000000000000000000000000000003537 160.0
PYH2_k127_2103760_0 Starch synthase catalytic K16149 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 537.0
PYH2_k127_2103760_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826,K02619 - 2.6.1.42,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 292.0
PYH2_k127_2103760_2 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001557 269.0
PYH2_k127_2103760_3 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000002376 232.0
PYH2_k127_2103760_4 Permease, YjgP YjgQ - - - 0.00000000000000000000000006169 125.0
PYH2_k127_2103760_5 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000000632 107.0
PYH2_k127_2103760_6 mRNA binding - - - 0.00000000000000000000001523 103.0
PYH2_k127_2107218_0 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 334.0
PYH2_k127_2107218_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000003652 262.0
PYH2_k127_2107218_2 PIN domain K07063 - - 0.000001455 56.0
PYH2_k127_2107218_3 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0004181 48.0
PYH2_k127_214713_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1566.0
PYH2_k127_214713_1 membrane transporter protein K07090 - - 9.591e-196 617.0
PYH2_k127_214713_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004859 266.0
PYH2_k127_214713_11 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000000000000000000000006009 227.0
PYH2_k127_214713_12 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000601 175.0
PYH2_k127_214713_13 transcriptional K03710 - - 0.00000000000000000000000000000007213 134.0
PYH2_k127_214713_14 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000001178 128.0
PYH2_k127_214713_16 Belongs to the universal stress protein A family - - - 0.000000000000002114 85.0
PYH2_k127_214713_17 PilZ domain - - - 0.000000000001788 74.0
PYH2_k127_214713_18 YtkA-like - - - 0.00000000001069 72.0
PYH2_k127_214713_2 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 602.0
PYH2_k127_214713_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 569.0
PYH2_k127_214713_4 protein secretion K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 530.0
PYH2_k127_214713_5 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 445.0
PYH2_k127_214713_6 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 424.0
PYH2_k127_214713_7 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 387.0
PYH2_k127_214713_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 381.0
PYH2_k127_214713_9 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 293.0
PYH2_k127_2181884_0 Fibronectin type 3 domain - - - 0.0000000000000000000000003943 121.0
PYH2_k127_2201097_0 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 506.0
PYH2_k127_2201097_1 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528,K16951 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000009697 260.0
PYH2_k127_2201097_2 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000002556 184.0
PYH2_k127_2267533_0 CoA binding domain K09181 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 494.0
PYH2_k127_2267533_1 e3 binding domain K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 469.0
PYH2_k127_2267533_10 - - - - 0.00000000000000000021 93.0
PYH2_k127_2267533_2 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 356.0
PYH2_k127_2267533_3 endonuclease III K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 309.0
PYH2_k127_2267533_4 Protein of unknown function (DUF4197) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003478 283.0
PYH2_k127_2267533_5 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000001564 208.0
PYH2_k127_2267533_6 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000004396 159.0
PYH2_k127_2267533_7 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000000779 162.0
PYH2_k127_2267533_8 phosphorelay sensor kinase activity K07708,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61 0.0000000000000000000000000000000000002143 158.0
PYH2_k127_2267533_9 CheY-like receiver AAA-type ATPase and DNA-binding domains K10126 - - 0.00000000000000000004628 104.0
PYH2_k127_2281940_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1661.0
PYH2_k127_2281940_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.631e-252 796.0
PYH2_k127_2281940_10 HlyD family secretion protein - - - 0.000000000000000000008553 105.0
PYH2_k127_2281940_2 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 396.0
PYH2_k127_2281940_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 386.0
PYH2_k127_2281940_4 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 310.0
PYH2_k127_2281940_5 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000001408 226.0
PYH2_k127_2281940_6 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000000006324 162.0
PYH2_k127_2281940_8 transcriptional regulator - - - 0.00000000000000000000000007287 115.0
PYH2_k127_2281940_9 Glu-tRNAGln amidotransferase C subunit K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000002166 104.0
PYH2_k127_2291726_0 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0 1092.0
PYH2_k127_2291726_1 inositol-3-phosphate synthase activity K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 523.0
PYH2_k127_2291726_10 Thioredoxin-like domain K03671 - - 0.00000000000000000000000000000000000000000000000002545 183.0
PYH2_k127_2291726_11 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000003435 149.0
PYH2_k127_2291726_12 Domain of unknown function (DUF4416) - - - 0.00000000000000000000000000000000003089 141.0
PYH2_k127_2291726_13 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000001987 135.0
PYH2_k127_2291726_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000001231 122.0
PYH2_k127_2291726_15 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000003024 106.0
PYH2_k127_2291726_17 protein secretion K03116,K03117 - - 0.00000000000001968 78.0
PYH2_k127_2291726_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 447.0
PYH2_k127_2291726_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 398.0
PYH2_k127_2291726_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 400.0
PYH2_k127_2291726_5 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 351.0
PYH2_k127_2291726_6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 337.0
PYH2_k127_2291726_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007918 279.0
PYH2_k127_2291726_8 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000001067 225.0
PYH2_k127_2324782_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 7.634e-295 913.0
PYH2_k127_2324782_1 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000307 258.0
PYH2_k127_2324782_2 Cache domain - - - 0.000000000000000000000000000000000000000000000000000000000002309 213.0
PYH2_k127_2324782_3 Domains HAMP, HisKA, HATPase_c, REC K02030 - - 0.000000000000000000000000000000001165 134.0
PYH2_k127_2324782_4 Spermine/spermidine synthase domain - - - 0.00000000000000000006446 95.0
PYH2_k127_2331406_0 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007538 544.0
PYH2_k127_2331406_1 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 349.0
PYH2_k127_2331406_10 cytochrome complex assembly - - - 0.00000003135 55.0
PYH2_k127_2331406_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 344.0
PYH2_k127_2331406_3 Metal-dependent phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000008097 226.0
PYH2_k127_2331406_4 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000001085 186.0
PYH2_k127_2331406_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000003669 175.0
PYH2_k127_2331406_6 cytochrome c biogenesis protein - - - 0.0000000000000000000000000000000007388 139.0
PYH2_k127_2331406_7 Glutathione peroxidase - - - 0.0000000000000000000000000000002489 129.0
PYH2_k127_2331406_8 - - - - 0.0000000000000000000000000001294 119.0
PYH2_k127_2331406_9 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000006945 70.0
PYH2_k127_2336080_0 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 418.0
PYH2_k127_2336080_1 CO dehydrogenase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
PYH2_k127_2336080_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.00000000000000000000000000000000000003911 152.0
PYH2_k127_2336080_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000183 97.0
PYH2_k127_2363047_0 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 327.0
PYH2_k127_2363047_1 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000001758 240.0
PYH2_k127_2363047_2 Peptidase family M48 - - - 0.0000000000000000001055 100.0
PYH2_k127_2369706_0 PD-(D/E)XK nuclease superfamily - - - 9.678e-205 669.0
PYH2_k127_2369706_1 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 514.0
PYH2_k127_2396983_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1163.0
PYH2_k127_2396983_1 GXGXG motif - - - 0.0 1014.0
PYH2_k127_2396983_2 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 5.559e-314 971.0
PYH2_k127_2396983_3 Glutamate synthase - - - 8.816e-219 691.0
PYH2_k127_2396983_4 glutamate synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 474.0
PYH2_k127_2396983_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008549 403.0
PYH2_k127_2396983_6 PFAM Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 398.0
PYH2_k127_2396983_7 Beta-lactamase K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000002106 205.0
PYH2_k127_2396983_8 PFAM Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000005489 159.0
PYH2_k127_2413051_0 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004209 257.0
PYH2_k127_2413051_1 PFAM ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000001733 205.0
PYH2_k127_2418981_0 sister chromatid segregation - - - 2.65e-204 647.0
PYH2_k127_2418981_1 Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 579.0
PYH2_k127_2418981_10 response regulator receiver - - - 0.0000000000000000000000000000000000007951 150.0
PYH2_k127_2418981_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 463.0
PYH2_k127_2418981_3 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 402.0
PYH2_k127_2418981_4 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 295.0
PYH2_k127_2418981_5 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003725 252.0
PYH2_k127_2418981_6 - - - - 0.00000000000000000000000000000000000000000000000000000004427 203.0
PYH2_k127_2418981_7 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000002068 200.0
PYH2_k127_2418981_8 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000002461 199.0
PYH2_k127_2418981_9 radical SAM K06871 - - 0.0000000000000000000000000000000000000002638 167.0
PYH2_k127_2422601_0 GTP-binding protein TypA K06207 - - 4.922e-268 839.0
PYH2_k127_2422601_1 sugar transferase K00996 - 2.7.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 383.0
PYH2_k127_2422601_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000008592 173.0
PYH2_k127_2445602_0 - - - - 0.00000000000000000000000000000000000000003232 168.0
PYH2_k127_2445602_1 Protein of unknown function (DUF3604) - - - 0.000000000000000000000000000000000001436 138.0
PYH2_k127_2445602_2 Protein of unknown function (DUF3313) - - - 0.00000000000000000004365 97.0
PYH2_k127_2445602_3 - - - - 0.000000000000000006448 89.0
PYH2_k127_2447895_0 - - - - 0.00000000000005628 76.0
PYH2_k127_2447895_1 signal-transduction protein containing cAMP-binding and CBS domains K03281,K08714,K16922 - - 0.0000000000004509 76.0
PYH2_k127_2469574_0 phosphate acetyltransferase K00625,K13788 - 2.3.1.8 3.351e-268 844.0
PYH2_k127_2469574_1 Phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 405.0
PYH2_k127_2530603_0 PFAM ferredoxin-dependent glutamate synthase - - - 1.46e-291 901.0
PYH2_k127_2530603_1 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 394.0
PYH2_k127_2530603_2 Methylene-tetrahydrofolate reductase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006274 244.0
PYH2_k127_2530603_3 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000001281 93.0
PYH2_k127_2544148_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 582.0
PYH2_k127_2544148_1 Mannose-6-phosphate isomerase, type K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 554.0
PYH2_k127_2544148_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000178 223.0
PYH2_k127_258456_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 5.412e-291 909.0
PYH2_k127_258456_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001163 236.0
PYH2_k127_258456_2 PFAM Radical SAM domain protein K02585 - - 0.00000000000000000000000000000000000000000000001804 184.0
PYH2_k127_258456_3 Membrane - - - 0.0004035 45.0
PYH2_k127_2620595_0 family UPF0324 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 544.0
PYH2_k127_2620595_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 403.0
PYH2_k127_2620595_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 333.0
PYH2_k127_2620595_3 COG0564 Pseudouridylate synthases, 23S RNA-specific K06177 - 5.4.99.28,5.4.99.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002706 274.0
PYH2_k127_2620595_4 PFAM Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000404 231.0
PYH2_k127_2620595_5 YtkA-like - - - 0.00000000000000000000000000004409 130.0
PYH2_k127_2620595_6 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000002008 61.0
PYH2_k127_2620595_7 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000004287 59.0
PYH2_k127_2673422_0 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 451.0
PYH2_k127_2673422_1 response regulator K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 420.0
PYH2_k127_2673422_10 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000001457 90.0
PYH2_k127_2673422_11 Belongs to the UPF0434 family K09791 - - 0.000000000000002635 77.0
PYH2_k127_2673422_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 407.0
PYH2_k127_2673422_3 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 331.0
PYH2_k127_2673422_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000027 300.0
PYH2_k127_2673422_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000285 235.0
PYH2_k127_2673422_6 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000113 191.0
PYH2_k127_2673422_7 His Kinase A (phosphoacceptor) domain K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000003459 191.0
PYH2_k127_2673422_8 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000002294 174.0
PYH2_k127_2673422_9 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000001559 154.0
PYH2_k127_27272_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.54e-287 900.0
PYH2_k127_27272_1 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000129 53.0
PYH2_k127_2732069_0 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 603.0
PYH2_k127_2732069_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 501.0
PYH2_k127_2732069_2 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 460.0
PYH2_k127_2732069_3 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 443.0
PYH2_k127_2732069_4 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 316.0
PYH2_k127_2732069_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 321.0
PYH2_k127_2732069_6 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000000000000000000000000000000003213 188.0
PYH2_k127_2732069_7 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000005198 100.0
PYH2_k127_2737535_0 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K02029,K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 563.0
PYH2_k127_2737535_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 469.0
PYH2_k127_2737535_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008617 394.0
PYH2_k127_2737535_3 Large family of predicted nucleotide-binding domains K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 356.0
PYH2_k127_2737535_4 (ABC) transporter K02028,K02029 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 305.0
PYH2_k127_2737535_5 Secretin and TonB N terminus short domain K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003438 287.0
PYH2_k127_2737535_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000003138 170.0
PYH2_k127_2760459_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 594.0
PYH2_k127_2760459_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 497.0
PYH2_k127_2760459_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 432.0
PYH2_k127_2760459_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 394.0
PYH2_k127_2760459_4 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 354.0
PYH2_k127_2760459_5 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001291 282.0
PYH2_k127_2760459_6 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007299 272.0
PYH2_k127_2760459_7 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001911 270.0
PYH2_k127_2760459_8 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000001017 223.0
PYH2_k127_2760459_9 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000007854 172.0
PYH2_k127_2814921_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 9.832e-274 865.0
PYH2_k127_2814921_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001586 302.0
PYH2_k127_2814921_2 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003655 272.0
PYH2_k127_2814921_3 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - 0.0000000000000000000000000001088 119.0
PYH2_k127_2814921_4 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000001979 96.0
PYH2_k127_2814921_5 ABC transporter substrate binding protein K01989 - - 0.0000003795 54.0
PYH2_k127_2826594_0 4Fe-4S dicluster domain - - - 1.942e-307 947.0
PYH2_k127_2826594_1 Surface antigen K07277 - - 5.092e-230 736.0
PYH2_k127_2826594_10 PFAM Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007842 424.0
PYH2_k127_2826594_11 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 432.0
PYH2_k127_2826594_12 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 385.0
PYH2_k127_2826594_13 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009373 376.0
PYH2_k127_2826594_14 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 321.0
PYH2_k127_2826594_15 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001648 259.0
PYH2_k127_2826594_16 cyclic diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002692 258.0
PYH2_k127_2826594_17 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003295 243.0
PYH2_k127_2826594_18 lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001479 254.0
PYH2_k127_2826594_19 cyclic diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000009375 239.0
PYH2_k127_2826594_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 9.157e-218 685.0
PYH2_k127_2826594_20 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000001228 218.0
PYH2_k127_2826594_21 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000002179 214.0
PYH2_k127_2826594_22 part of a sulfur-relay system K11179 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - 0.000000000000000000000000000000000000000000000000000698 185.0
PYH2_k127_2826594_23 - - - - 0.00000000000000000000000000000000000000000000000003165 181.0
PYH2_k127_2826594_24 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000006203 187.0
PYH2_k127_2826594_25 lyase activity - - - 0.0000000000000000000000000000000000000000000000001484 200.0
PYH2_k127_2826594_26 PFAM Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000000005402 169.0
PYH2_k127_2826594_27 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.00000000000000000000000000000000000000000003792 166.0
PYH2_k127_2826594_28 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000002075 158.0
PYH2_k127_2826594_29 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.0000000000000000000000000000000000001269 148.0
PYH2_k127_2826594_3 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 587.0
PYH2_k127_2826594_30 Protein of unknown function (DUF2752) - - - 0.00000000000000000000000000000000002391 139.0
PYH2_k127_2826594_31 12 heme-binding sites - - - 0.0000000000000000000000000000000000374 143.0
PYH2_k127_2826594_32 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000002623 138.0
PYH2_k127_2826594_33 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000006184 129.0
PYH2_k127_2826594_34 response to antibiotic - - - 0.0000000000000000000000000000002465 126.0
PYH2_k127_2826594_36 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000001398 123.0
PYH2_k127_2826594_37 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000001316 123.0
PYH2_k127_2826594_38 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000006718 109.0
PYH2_k127_2826594_39 4Fe-4S binding domain - - - 0.000000000000000000009509 93.0
PYH2_k127_2826594_4 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 589.0
PYH2_k127_2826594_40 lyase activity - - - 0.0000000000001704 74.0
PYH2_k127_2826594_41 sulfur carrier activity - GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.00000000279 61.0
PYH2_k127_2826594_42 TM2 domain - - - 0.000005109 55.0
PYH2_k127_2826594_43 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions K07237 GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - 0.000005493 53.0
PYH2_k127_2826594_45 DsrE/DsrF-like family - - - 0.00003119 51.0
PYH2_k127_2826594_5 Nitrite and sulphite reductase 4Fe-4S K11181 - 1.8.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 548.0
PYH2_k127_2826594_6 Bacterial regulatory protein, Fis family K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 517.0
PYH2_k127_2826594_7 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 503.0
PYH2_k127_2826594_8 GHKL domain K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 514.0
PYH2_k127_2826594_9 phosphorelay signal transduction system K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 447.0
PYH2_k127_2845177_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 2.027e-265 839.0
PYH2_k127_2845177_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 441.0
PYH2_k127_2845177_10 DNA protecting protein DprA K04096 - - 0.0000000000004474 72.0
PYH2_k127_2845177_12 - - - - 0.00000002885 56.0
PYH2_k127_2845177_13 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.00002268 54.0
PYH2_k127_2845177_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 382.0
PYH2_k127_2845177_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 359.0
PYH2_k127_2845177_4 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 350.0
PYH2_k127_2845177_5 PFAM cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 321.0
PYH2_k127_2845177_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.000000000000000000000000000000000000000000000000000000000000000000001166 248.0
PYH2_k127_2845177_7 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000006184 235.0
PYH2_k127_2845177_8 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.0000000000000000000000000000000000000001748 160.0
PYH2_k127_2845177_9 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000002418 122.0
PYH2_k127_2845971_0 Chromate K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 333.0
PYH2_k127_2845971_1 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000133 213.0
PYH2_k127_2845971_2 cobalamin synthesis protein, P47K - - - 0.000000000000000000000000000000000000000000005803 175.0
PYH2_k127_2845971_3 OsmC-like protein - - - 0.0000000000000000009571 94.0
PYH2_k127_2873445_0 Pyridoxal-phosphate dependent enzyme K06001 - 4.2.1.20 3.915e-217 682.0
PYH2_k127_2873445_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 9.627e-208 654.0
PYH2_k127_2873445_10 heat shock protein binding - - - 0.000000000000000000000000000000000007651 148.0
PYH2_k127_2873445_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 539.0
PYH2_k127_2873445_3 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008904 445.0
PYH2_k127_2873445_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 410.0
PYH2_k127_2873445_5 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000006287 243.0
PYH2_k127_2873445_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001194 230.0
PYH2_k127_2873445_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000885 229.0
PYH2_k127_2873445_8 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000009875 191.0
PYH2_k127_2873445_9 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594 - 1.16.3.1 0.00000000000000000000000000000000000000003365 156.0
PYH2_k127_2882013_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.469e-194 615.0
PYH2_k127_2882013_1 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000001004 234.0
PYH2_k127_2882013_2 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000003549 144.0
PYH2_k127_2882013_3 DNA protecting protein DprA K04096 - - 0.000003068 51.0
PYH2_k127_2884012_0 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 4.573e-198 644.0
PYH2_k127_2884012_1 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 488.0
PYH2_k127_2884012_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 368.0
PYH2_k127_2884012_3 histidine kinase HAMP region domain protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006662 263.0
PYH2_k127_2884012_4 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005655 254.0
PYH2_k127_2884012_5 PFAM response regulator receiver K03413 - - 0.000000000000000000000000000000000000000000007306 165.0
PYH2_k127_2884012_6 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000003168 154.0
PYH2_k127_2884012_7 redox protein regulator of disulfide bond formation K07397 - - 0.00000000000001109 77.0
PYH2_k127_2884012_8 STAS domain - - - 0.0000000000006774 73.0
PYH2_k127_2921103_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 540.0
PYH2_k127_2921103_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 361.0
PYH2_k127_2921103_2 PFAM peptidase M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005755 289.0
PYH2_k127_2921103_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000009858 243.0
PYH2_k127_2921103_4 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000004752 176.0
PYH2_k127_2921103_5 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000004084 171.0
PYH2_k127_2921103_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000004786 135.0
PYH2_k127_2921103_7 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000003089 124.0
PYH2_k127_2921103_8 Tetratricopeptide repeat - - - 0.0000000000000000002732 102.0
PYH2_k127_2921103_9 Roadblock/LC7 domain - - - 0.00000000000000002817 86.0
PYH2_k127_2940998_0 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.0000000000000000000000000000000000000000000000000000000000001004 221.0
PYH2_k127_2940998_1 TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000004893 161.0
PYH2_k127_2940998_2 overlaps another CDS with the same product name - - - 0.00000000000384 72.0
PYH2_k127_2944849_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1118.0
PYH2_k127_2944849_1 PFAM Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 482.0
PYH2_k127_2944849_2 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000211 230.0
PYH2_k127_2944849_3 response regulator - - - 0.0000000000000000000000000000000003385 145.0
PYH2_k127_2944849_4 Putative regulatory protein - - - 0.00000001803 58.0
PYH2_k127_2944849_5 - - - - 0.0001065 50.0
PYH2_k127_2978828_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 1.422e-200 639.0
PYH2_k127_2978828_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 362.0
PYH2_k127_2978828_2 Preprotein translocase subunit K03210 - - 0.00000000000000000000000000000009151 127.0
PYH2_k127_2978828_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000003025 96.0
PYH2_k127_298846_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000886 213.0
PYH2_k127_298846_1 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000007155 183.0
PYH2_k127_298846_2 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000001457 157.0
PYH2_k127_298846_3 Domain of unknown function (DUF3786) - - - 0.000000000000000000000000000000000000004502 153.0
PYH2_k127_2989755_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006736 559.0
PYH2_k127_2989755_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009741 458.0
PYH2_k127_2989755_11 Protein of unknown function (DUF2905) - - - 0.00000000000000000136 90.0
PYH2_k127_2989755_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 319.0
PYH2_k127_2989755_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 318.0
PYH2_k127_2989755_4 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 300.0
PYH2_k127_2989755_5 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001973 280.0
PYH2_k127_2989755_6 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000228 261.0
PYH2_k127_2989755_7 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.000000000000000000000000000000000000000000000000000003418 196.0
PYH2_k127_2989755_8 four-way junction helicase activity K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000000002191 186.0
PYH2_k127_2989755_9 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000001294 152.0
PYH2_k127_2995556_0 Histidine kinase - - - 7.279e-195 648.0
PYH2_k127_2995556_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 428.0
PYH2_k127_2995556_10 PFAM HhH-GPD superfamily base excision DNA repair protein K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005194 272.0
PYH2_k127_2995556_11 Carbohydrate-binding family 9 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002912 239.0
PYH2_k127_2995556_12 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000003883 239.0
PYH2_k127_2995556_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000009794 220.0
PYH2_k127_2995556_14 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000002402 234.0
PYH2_k127_2995556_15 Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L- methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by K22466 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.23 0.0000000000000000000000000000000000000000000000000000007586 199.0
PYH2_k127_2995556_16 esterase - - - 0.0000000000000000000000000000000000000000000000000001598 197.0
PYH2_k127_2995556_17 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000001304 190.0
PYH2_k127_2995556_18 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000001079 179.0
PYH2_k127_2995556_19 Archaea-specific editing domain of threonyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000005856 167.0
PYH2_k127_2995556_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 400.0
PYH2_k127_2995556_20 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000673 162.0
PYH2_k127_2995556_21 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000154 158.0
PYH2_k127_2995556_22 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000006192 154.0
PYH2_k127_2995556_23 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.0000000000000000000000000000000004128 138.0
PYH2_k127_2995556_24 Sulphur transport K07112 - - 0.0000000000000000000000000000000009043 136.0
PYH2_k127_2995556_25 diguanylate cyclase - - - 0.000000000000000000000000000006047 129.0
PYH2_k127_2995556_26 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000008877 115.0
PYH2_k127_2995556_27 Protein of unknown function (DUF3617) - - - 0.000000000000000000003563 100.0
PYH2_k127_2995556_28 adenylate cyclase carring two-component hybrid sensor and regulator domains - - - 0.000000000000004801 84.0
PYH2_k127_2995556_29 - - - - 0.0004233 52.0
PYH2_k127_2995556_3 Protein of unknown function (DUF1847) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 375.0
PYH2_k127_2995556_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 349.0
PYH2_k127_2995556_5 geranylgeranyl reductase activity K14266 - 1.14.19.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 357.0
PYH2_k127_2995556_6 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 345.0
PYH2_k127_2995556_7 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 301.0
PYH2_k127_2995556_8 Response regulator receiver domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 297.0
PYH2_k127_2995556_9 Belongs to the helicase family. UvrD subfamily K10742 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003736 278.0
PYH2_k127_3067449_0 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 603.0
PYH2_k127_3067449_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 298.0
PYH2_k127_3067449_2 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001215 278.0
PYH2_k127_3086120_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 387.0
PYH2_k127_3086120_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000002981 59.0
PYH2_k127_3129885_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.3e-308 968.0
PYH2_k127_3129885_1 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 496.0
PYH2_k127_3129885_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 490.0
PYH2_k127_3129885_3 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000000000000005252 186.0
PYH2_k127_3129885_4 DegT/DnrJ/EryC1/StrS aminotransferase family K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000001029 164.0
PYH2_k127_3129885_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000000000001905 144.0
PYH2_k127_3129885_6 Gram-negative-bacterium-type cell outer membrane assembly K04064,K06186 GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 - 0.000000000000000000000000105 109.0
PYH2_k127_3129885_7 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000001333 107.0
PYH2_k127_3129885_8 Modulates RecA activity K03565 - - 0.0000000000000000002291 94.0
PYH2_k127_3177120_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 6.219e-277 864.0
PYH2_k127_3177120_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 603.0
PYH2_k127_3177120_10 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000006866 184.0
PYH2_k127_3177120_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000002473 186.0
PYH2_k127_3177120_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000001513 153.0
PYH2_k127_3177120_13 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000262 124.0
PYH2_k127_3177120_14 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000002355 138.0
PYH2_k127_3177120_15 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000006536 115.0
PYH2_k127_3177120_16 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000003953 94.0
PYH2_k127_3177120_17 mercury ion transmembrane transporter activity K07213 - - 0.0000000000008603 70.0
PYH2_k127_3177120_18 cheY-homologous receiver domain - - - 0.00002914 51.0
PYH2_k127_3177120_2 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 515.0
PYH2_k127_3177120_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 458.0
PYH2_k127_3177120_4 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 314.0
PYH2_k127_3177120_5 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 302.0
PYH2_k127_3177120_6 dUTP biosynthetic process K01494 GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000003175 261.0
PYH2_k127_3177120_7 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000002369 224.0
PYH2_k127_3177120_8 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000000000000000003955 209.0
PYH2_k127_3177120_9 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000001387 196.0
PYH2_k127_3183732_0 FAD binding domain K00278 - 1.4.3.16 2.057e-194 621.0
PYH2_k127_3183732_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 412.0
PYH2_k127_3183732_2 Bacterial regulatory protein, Fis family K13599 - - 0.00000000000000004671 82.0
PYH2_k127_3194814_0 Sugar (and other) transporter K03446 - - 2.175e-232 728.0
PYH2_k127_3194814_1 ABC1 family K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 578.0
PYH2_k127_3194814_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000217 282.0
PYH2_k127_3194814_3 O-methyltransferase family 3 - - - 0.000000000000000000000000000000000000000000000000000000002762 209.0
PYH2_k127_3194814_4 PFAM secretion protein HlyD family protein K03543 - - 0.0000000000000000000000000000000000000000000000000001235 188.0
PYH2_k127_3194814_5 - - - - 0.00000000000001348 77.0
PYH2_k127_321571_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 366.0
PYH2_k127_321571_1 Bacterial type II and III secretion system protein K02453,K03219 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 351.0
PYH2_k127_321571_2 Protein of unknown function (DUF1189) - - - 0.00000000000000000003417 98.0
PYH2_k127_321571_3 Fimbrial assembly protein (PilN) K02461 - - 0.000000000000003003 87.0
PYH2_k127_3255537_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.923e-194 613.0
PYH2_k127_3255537_1 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001616 281.0
PYH2_k127_3255537_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004342 274.0
PYH2_k127_3255537_3 PFAM HhH-GPD superfamily base excision DNA repair protein K07457 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003265 260.0
PYH2_k127_3255537_4 ATP cone domain - - - 0.00000000000000000000000000000000000000000000000000000000000001193 223.0
PYH2_k127_3255537_5 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000001285 161.0
PYH2_k127_3255537_6 translation release factor activity - - - 0.00000000000000000000000000000000000002827 148.0
PYH2_k127_3290911_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 419.0
PYH2_k127_3290911_1 Putative RNA methylase family UPF0020 K07444,K12297 - 2.1.1.173,2.1.1.264 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 312.0
PYH2_k127_3290911_2 TIGRFAM oligoendopeptidase, M3 family K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005615 278.0
PYH2_k127_3290911_3 Alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001284 256.0
PYH2_k127_3290911_4 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000008551 184.0
PYH2_k127_3290911_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000004043 166.0
PYH2_k127_3290911_6 Belongs to the methyltransferase superfamily K07444,K12297 - 2.1.1.173,2.1.1.264 0.0000000000000000000000000000000000000000000917 164.0
PYH2_k127_3425654_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 582.0
PYH2_k127_3506125_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1096.0
PYH2_k127_3506125_1 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 439.0
PYH2_k127_3506125_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000001574 119.0
PYH2_k127_351873_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 3.165e-306 947.0
PYH2_k127_351873_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.639e-248 778.0
PYH2_k127_351873_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.737e-199 630.0
PYH2_k127_351873_3 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 494.0
PYH2_k127_351873_4 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 415.0
PYH2_k127_351873_5 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 372.0
PYH2_k127_351873_6 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000001324 267.0
PYH2_k127_351873_7 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007511 249.0
PYH2_k127_351873_8 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000004453 155.0
PYH2_k127_3540312_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00123,K00336,K05299,K06441 - 1.12.7.2,1.17.1.10,1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 281.0
PYH2_k127_3540312_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000002756 218.0
PYH2_k127_3540312_2 Uncharacterized protein conserved in bacteria (DUF2059) - - - 0.0000000002945 72.0
PYH2_k127_3736256_0 GHKL domain K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 316.0
PYH2_k127_3780378_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.758e-239 750.0
PYH2_k127_3780378_1 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 602.0
PYH2_k127_3780378_2 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001588 268.0
PYH2_k127_3780378_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000122 244.0
PYH2_k127_3780378_4 Proposed homoserine kinase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000002747 171.0
PYH2_k127_3791569_0 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000514 164.0
PYH2_k127_3791569_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000007471 153.0
PYH2_k127_3791569_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000002005 63.0
PYH2_k127_3834968_0 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 7.524e-250 784.0
PYH2_k127_3834968_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 613.0
PYH2_k127_3834968_2 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 460.0
PYH2_k127_3834968_3 Mo-molybdopterin cofactor metabolic process K02379 - - 0.0000000000000000000000000000000000000000000000000000000000009738 218.0
PYH2_k127_3834968_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000002797 156.0
PYH2_k127_3834968_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000003453 121.0
PYH2_k127_3834968_6 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.0000003065 55.0
PYH2_k127_3835799_0 DEAD DEAH box helicase K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000006177 237.0
PYH2_k127_3835799_1 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000003862 135.0
PYH2_k127_3835799_2 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000001645 129.0
PYH2_k127_3835799_3 epimerase dehydratase K19997 - 5.1.3.26 0.00000000000000000000000008257 110.0
PYH2_k127_3850239_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 1.482e-240 755.0
PYH2_k127_3850239_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 443.0
PYH2_k127_3850239_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009569 361.0
PYH2_k127_3850239_3 Prolyl oligopeptidase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001316 280.0
PYH2_k127_3850239_4 Rubrerythrin - - - 0.0000000000000005695 84.0
PYH2_k127_3854195_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000995 520.0
PYH2_k127_3854195_1 response regulator K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 497.0
PYH2_k127_3854195_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000002586 66.0
PYH2_k127_3854195_2 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 384.0
PYH2_k127_3854195_3 histidine kinase, HAMP K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 349.0
PYH2_k127_3854195_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000003579 200.0
PYH2_k127_3854195_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000001761 202.0
PYH2_k127_3854195_6 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.000000000000000000000000000000000000000002274 160.0
PYH2_k127_3854195_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000003716 149.0
PYH2_k127_3854195_8 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000001937 132.0
PYH2_k127_3854195_9 cheY-homologous receiver domain - - - 0.000000000000000000000000003094 117.0
PYH2_k127_3860496_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 438.0
PYH2_k127_3860496_1 radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 381.0
PYH2_k127_3860496_2 AMMECR1 K06990,K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 351.0
PYH2_k127_3860496_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003569 256.0
PYH2_k127_3860496_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002486 237.0
PYH2_k127_3860496_5 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.00000000000000000000000000000000000000000000000000000000000001145 227.0
PYH2_k127_3860496_6 virion core protein, lumpy skin disease virus - - - 0.00000000000000000000000000000000000000000000000000000000000262 222.0
PYH2_k127_3860496_7 - - - - 0.000000000000000000000000000000000000000000001629 170.0
PYH2_k127_3860496_8 - - - - 0.000000000000000000000006686 103.0
PYH2_k127_3880444_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.581e-207 668.0
PYH2_k127_3880444_1 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 424.0
PYH2_k127_3880444_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 376.0
PYH2_k127_3880444_3 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000006817 260.0
PYH2_k127_3880444_4 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000002124 219.0
PYH2_k127_3880444_5 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000007502 222.0
PYH2_k127_3880444_6 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000003774 164.0
PYH2_k127_3880444_7 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000002532 131.0
PYH2_k127_3880444_8 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.00000000000000000000000000003695 119.0
PYH2_k127_3892894_0 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000003005 252.0
PYH2_k127_3892894_1 Protein export membrane protein K07003 - - 0.0000000000000000000000000000000000000000000000000000000000004357 237.0
PYH2_k127_3892894_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000005238 195.0
PYH2_k127_3892894_3 PFAM Acyl transferase K00645 - 2.3.1.39 0.00000000000000000000000000000001593 136.0
PYH2_k127_3892894_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000007749 97.0
PYH2_k127_3892894_5 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000795 77.0
PYH2_k127_3892894_6 metallopeptidase activity - - - 0.00001259 57.0
PYH2_k127_3916460_0 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 445.0
PYH2_k127_3916460_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 421.0
PYH2_k127_3916460_2 metal-dependent phosphohydrolase HD region K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 392.0
PYH2_k127_3916460_3 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 334.0
PYH2_k127_3916460_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 333.0
PYH2_k127_3916460_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000334 252.0
PYH2_k127_3916460_6 GAF domain - - - 0.000000000000000000000000000000000000000000000000001363 206.0
PYH2_k127_3916460_7 Dehydratase family K01687 - 4.2.1.9 0.0000000000000000000001186 97.0
PYH2_k127_3916460_8 Protein of unknown function (DUF465) K09794 - - 0.0000000000000000002499 89.0
PYH2_k127_393088_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 597.0
PYH2_k127_393088_1 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 413.0
PYH2_k127_393088_2 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 370.0
PYH2_k127_393088_3 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 325.0
PYH2_k127_393088_4 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000000015 231.0
PYH2_k127_393088_5 Formylmethanofuran dehydrogenase, subunit e K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000004144 222.0
PYH2_k127_393088_6 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000001642 213.0
PYH2_k127_393088_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000000000008235 184.0
PYH2_k127_3956699_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 525.0
PYH2_k127_3956699_1 Peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 514.0
PYH2_k127_3956699_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 301.0
PYH2_k127_3956699_3 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000001693 254.0
PYH2_k127_3956699_4 Diguanylate cyclase - - - 0.0000000000000000000000000000008935 129.0
PYH2_k127_3978487_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 358.0
PYH2_k127_3978487_1 Transcriptional regulatory protein, C terminal K07664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003274 248.0
PYH2_k127_3978487_2 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002264 217.0
PYH2_k127_3978487_3 RNA-binding protein containing a PIN domain K06962 - - 0.000000000000000000000000000005762 124.0
PYH2_k127_3978487_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000004474 89.0
PYH2_k127_3978920_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 483.0
PYH2_k127_3978920_1 PFAM ATPase BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 394.0
PYH2_k127_3978920_10 Type IV pilus assembly - - - 0.0004912 51.0
PYH2_k127_3978920_2 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 373.0
PYH2_k127_3978920_3 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 332.0
PYH2_k127_3978920_4 PFAM CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 310.0
PYH2_k127_3978920_5 PFAM CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0000000000000000000000000000000000000000000000000000001618 209.0
PYH2_k127_3978920_6 Response regulator receiver domain K03413 - - 0.00000000000000000000000000000000000000000001071 169.0
PYH2_k127_3978920_7 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000003656 120.0
PYH2_k127_3978920_9 denitrification pathway K03532 - - 0.000005871 52.0
PYH2_k127_3982696_0 Elongation factor Tu domain 2 K03833 - - 0.0000000000000000000000000000000001835 141.0
PYH2_k127_3982696_2 Protein of unknown function (DUF1523) - - - 0.0009222 42.0
PYH2_k127_398508_0 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 512.0
PYH2_k127_398508_1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 415.0
PYH2_k127_398508_2 Sensory domain found in PocR - - - 0.0000000000000000000000000000000000000000000000000000000000000000007065 255.0
PYH2_k127_398508_3 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000826 177.0
PYH2_k127_398508_4 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000003415 101.0
PYH2_k127_398508_5 YMGG-like Gly-zipper - - - 0.00002982 53.0
PYH2_k127_4050964_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 2.454e-235 740.0
PYH2_k127_4050964_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 323.0
PYH2_k127_4050964_2 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000008598 253.0
PYH2_k127_4059426_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 500.0
PYH2_k127_4064356_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 371.0
PYH2_k127_4064356_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 310.0
PYH2_k127_4064356_2 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000001204 248.0
PYH2_k127_4064356_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007035 239.0
PYH2_k127_4064356_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000000000000000000000006867 194.0
PYH2_k127_4064356_5 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000001086 182.0
PYH2_k127_4064356_6 Lytic transglycosylase - - - 0.000000000000000000000000000000000000000111 159.0
PYH2_k127_4064356_7 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000001056 126.0
PYH2_k127_4064356_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000001654 109.0
PYH2_k127_4064356_9 myo-inosose-2 dehydratase activity - - - 0.00006381 46.0
PYH2_k127_415813_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009041 365.0
PYH2_k127_415813_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 348.0
PYH2_k127_415813_2 PFAM ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000000000008055 195.0
PYH2_k127_415813_3 peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000000000000008595 152.0
PYH2_k127_415813_4 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000004529 98.0
PYH2_k127_41945_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 590.0
PYH2_k127_4208406_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 5.4e-323 1002.0
PYH2_k127_4208406_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 480.0
PYH2_k127_4208406_10 HD domain - - - 0.000000000000000000000000000000000000000000002829 168.0
PYH2_k127_4208406_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000005563 147.0
PYH2_k127_4208406_12 TIGRFAM 4-oxalocrotonate tautomerase family enzyme K01821 - 5.3.2.6 0.0000000000000000000000000002613 121.0
PYH2_k127_4208406_13 protein conserved in bacteria - - - 0.0000000000000000000007315 99.0
PYH2_k127_4208406_14 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000007028 94.0
PYH2_k127_4208406_15 S4 domain K14761 - - 0.000000000000000002654 89.0
PYH2_k127_4208406_16 Evidence 4 Homologs of previously reported genes of - - - 0.000000000001678 69.0
PYH2_k127_4208406_17 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000000005694 61.0
PYH2_k127_4208406_19 Tetratricopeptide repeat - - - 0.00009693 53.0
PYH2_k127_4208406_2 TIGRFAM cysteine K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 424.0
PYH2_k127_4208406_3 galactose-1-phosphate uridylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 355.0
PYH2_k127_4208406_4 ATP adenylyltransferase K00988 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002796 284.0
PYH2_k127_4208406_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001467 264.0
PYH2_k127_4208406_6 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000001597 247.0
PYH2_k127_4208406_7 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000003945 235.0
PYH2_k127_4208406_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000002173 224.0
PYH2_k127_4208406_9 - - - - 0.000000000000000000000000000000000000000000000003283 181.0
PYH2_k127_4230249_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 409.0
PYH2_k127_4230249_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 398.0
PYH2_k127_4230249_2 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 374.0
PYH2_k127_4230249_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000007365 204.0
PYH2_k127_4230249_4 Ribosomal protein S9/S16 K02996 - - 0.000000000000000000000000000000000000004592 155.0
PYH2_k127_4230249_5 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000005049 54.0
PYH2_k127_4289503_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 3.948e-233 737.0
PYH2_k127_4289503_1 glucosamine-1-phosphate N-acetyltransferase activity K04042,K11528,K16203 GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 425.0
PYH2_k127_4289503_2 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 370.0
PYH2_k127_4289503_3 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000004052 219.0
PYH2_k127_4289503_4 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000001442 169.0
PYH2_k127_4289503_5 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000002528 64.0
PYH2_k127_4321368_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 610.0
PYH2_k127_4321368_1 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 332.0
PYH2_k127_4321368_2 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000004723 222.0
PYH2_k127_4321368_3 PFAM Smr protein MutS2 - - - 0.00000000000000000000000002893 112.0
PYH2_k127_4321368_4 - - - - 0.000000000001216 74.0
PYH2_k127_4321368_5 Biotin carboxylase C-terminal domain K01965,K01968 - 6.4.1.3,6.4.1.4 0.0000008066 51.0
PYH2_k127_4326677_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 464.0
PYH2_k127_4326677_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009116 437.0
PYH2_k127_4326677_2 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 383.0
PYH2_k127_4326677_3 Domain of unknown function (DUF4129) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 365.0
PYH2_k127_4326677_4 RDD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 301.0
PYH2_k127_4326677_5 histone acetyltransferase binding - - - 0.0000000000000000000000000000000000000000000000000000000001061 220.0
PYH2_k127_4326677_6 - - - - 0.000000000000000000004939 96.0
PYH2_k127_4326677_7 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00005963 48.0
PYH2_k127_4342877_0 Domain of unknown function (DUF3413) K07014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 422.0
PYH2_k127_4342877_1 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 346.0
PYH2_k127_4342877_10 O-Antigen ligase - - - 0.0000000000001374 83.0
PYH2_k127_4342877_11 Glycosyltransferase GT-D fold - - - 0.0002323 52.0
PYH2_k127_4342877_2 ABC transporter transmembrane region K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 343.0
PYH2_k127_4342877_3 transferase activity, transferring glycosyl groups K02844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 317.0
PYH2_k127_4342877_4 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000003655 228.0
PYH2_k127_4342877_5 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000006734 207.0
PYH2_k127_4342877_6 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000001418 200.0
PYH2_k127_4342877_7 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000001586 192.0
PYH2_k127_4342877_8 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.00000000000000000000000000000000000004621 156.0
PYH2_k127_4342877_9 dephospho-CoA kinase activity - - - 0.000000000000000000000001146 109.0
PYH2_k127_4393327_0 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000003186 138.0
PYH2_k127_4393327_1 Amidohydrolase K01686 - 4.2.1.8 0.000000000000000000000000000000007887 141.0
PYH2_k127_4393327_2 - - - - 0.00000000000000251 80.0
PYH2_k127_4393327_3 - - - - 0.000000000007794 71.0
PYH2_k127_4393327_4 Cation transporter/ATPase, N-terminus K01539 - 3.6.3.9 0.0002405 44.0
PYH2_k127_4525943_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 574.0
PYH2_k127_4525943_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006652 266.0
PYH2_k127_4525943_2 topology modulation protein - - - 0.00000000000000000000000000008195 124.0
PYH2_k127_4525943_3 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000007081 108.0
PYH2_k127_4540299_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 620.0
PYH2_k127_4540299_1 Polypeptide-transport-associated domain protein ShlB-type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 481.0
PYH2_k127_4540299_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 469.0
PYH2_k127_4540299_3 lipoprotein transporter activity K02003,K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 306.0
PYH2_k127_4540299_4 - - - - 0.0000000000000000000000000001146 118.0
PYH2_k127_4540299_5 domain, Protein - - - 0.0000000000000000000000000008588 131.0
PYH2_k127_4540299_6 - - - - 0.00000000000000001799 86.0
PYH2_k127_4548676_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009271 255.0
PYH2_k127_4548676_1 SCO1 SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000811 207.0
PYH2_k127_4548676_2 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000001296 154.0
PYH2_k127_4585417_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 6.471e-208 654.0
PYH2_k127_4585417_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 385.0
PYH2_k127_4585417_10 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.000000000000000000000000000000000000000000000000000000000000000001776 233.0
PYH2_k127_4585417_11 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000006686 228.0
PYH2_k127_4585417_12 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
PYH2_k127_4585417_13 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000434 198.0
PYH2_k127_4585417_14 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000005236 198.0
PYH2_k127_4585417_15 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000006264 192.0
PYH2_k127_4585417_16 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000006021 184.0
PYH2_k127_4585417_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000001524 176.0
PYH2_k127_4585417_18 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000016 168.0
PYH2_k127_4585417_19 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000003143 161.0
PYH2_k127_4585417_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 345.0
PYH2_k127_4585417_20 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000003659 156.0
PYH2_k127_4585417_21 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000003885 149.0
PYH2_k127_4585417_22 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.00000000000000000000000000000000006635 134.0
PYH2_k127_4585417_23 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000007967 136.0
PYH2_k127_4585417_24 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000002268 132.0
PYH2_k127_4585417_25 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000001112 110.0
PYH2_k127_4585417_26 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000004388 106.0
PYH2_k127_4585417_27 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000003241 102.0
PYH2_k127_4585417_28 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000001149 73.0
PYH2_k127_4585417_29 Ribosomal protein L36 K02919 - - 0.0000000000001013 71.0
PYH2_k127_4585417_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 335.0
PYH2_k127_4585417_30 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000006774 73.0
PYH2_k127_4585417_31 ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000001424 68.0
PYH2_k127_4585417_4 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 318.0
PYH2_k127_4585417_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 290.0
PYH2_k127_4585417_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 283.0
PYH2_k127_4585417_7 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002821 282.0
PYH2_k127_4585417_8 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000188 283.0
PYH2_k127_4585417_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000001331 234.0
PYH2_k127_460296_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 426.0
PYH2_k127_460296_1 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 394.0
PYH2_k127_460296_10 - - - - 0.0000000000000000002623 96.0
PYH2_k127_460296_11 - - - - 0.0000000003156 66.0
PYH2_k127_460296_12 Belongs to the UPF0109 family K06960 - - 0.00001288 48.0
PYH2_k127_460296_2 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 294.0
PYH2_k127_460296_3 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 301.0
PYH2_k127_460296_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000007236 209.0
PYH2_k127_460296_5 PFAM iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000001527 190.0
PYH2_k127_460296_6 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000001973 143.0
PYH2_k127_460296_7 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000005262 123.0
PYH2_k127_460296_8 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000003908 110.0
PYH2_k127_460296_9 Ribosomal protein S16 K02959 - - 0.000000000000000000000003748 104.0
PYH2_k127_4607571_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 6.91e-204 641.0
PYH2_k127_4607571_1 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 541.0
PYH2_k127_4607571_10 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000008263 220.0
PYH2_k127_4607571_11 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000005815 205.0
PYH2_k127_4607571_12 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000001303 140.0
PYH2_k127_4607571_13 Bacterial regulatory protein, Fis family - - - 0.00000000000000008817 84.0
PYH2_k127_4607571_2 PFAM NADH Ubiquinone plastoquinone (complex I) K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 471.0
PYH2_k127_4607571_3 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 451.0
PYH2_k127_4607571_4 alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 422.0
PYH2_k127_4607571_5 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 383.0
PYH2_k127_4607571_6 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 364.0
PYH2_k127_4607571_7 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 361.0
PYH2_k127_4607571_8 PFAM ResB family protein K07399 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 369.0
PYH2_k127_4607571_9 PFAM NADH Ubiquinone - - - 0.00000000000000000000000000000000000000000000000000000000000000001002 229.0
PYH2_k127_4624399_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 585.0
PYH2_k127_4624399_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000966 201.0
PYH2_k127_4624399_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000002563 188.0
PYH2_k127_4624399_3 Phage integrase family - - - 0.000000000000000001296 87.0
PYH2_k127_4656648_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 600.0
PYH2_k127_4656648_1 Cache domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000001125 258.0
PYH2_k127_4656648_2 DNA-binding transcription factor activity K03710 - - 0.000000000000000000000000000000000000000000000000000000000005205 215.0
PYH2_k127_4656648_3 IMP dehydrogenase activity - - - 0.0000000000000000000000000000003269 129.0
PYH2_k127_4656648_4 cheY-homologous receiver domain - - - 0.0000000000000000000000005858 108.0
PYH2_k127_4656648_5 phosphorelay signal transduction system - - - 0.0000006466 52.0
PYH2_k127_4656648_6 ATP-binding region, ATPase domain protein - - - 0.00002002 55.0
PYH2_k127_4667965_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1226.0
PYH2_k127_4667965_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008071 260.0
PYH2_k127_4667965_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000003363 251.0
PYH2_k127_4667965_3 Polysulphide reductase, NrfD - - - 0.0000000000000000000000004747 108.0
PYH2_k127_4689730_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1420.0
PYH2_k127_4689730_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 503.0
PYH2_k127_4689730_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 494.0
PYH2_k127_4689730_3 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 399.0
PYH2_k127_4689730_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 345.0
PYH2_k127_4689730_5 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000006991 242.0
PYH2_k127_4689730_6 Domain of unknown function (DUF386) - - - 0.0000000000000000000000000000000000000000000000000005283 192.0
PYH2_k127_4689730_7 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000003566 102.0
PYH2_k127_4696800_0 Belongs to the GPI family K01810 - 5.3.1.9 5.74e-267 836.0
PYH2_k127_4696800_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 615.0
PYH2_k127_4696800_2 cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 377.0
PYH2_k127_4696800_3 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000001823 191.0
PYH2_k127_4696800_4 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000003591 164.0
PYH2_k127_4696800_5 - - - - 0.000000000000000000000000000000000000000007465 175.0
PYH2_k127_4696800_6 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000287 67.0
PYH2_k127_4704460_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1028.0
PYH2_k127_4704460_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.114e-214 674.0
PYH2_k127_4704460_10 - K00241 - - 0.0000000000000000000000000000000000000000000008449 177.0
PYH2_k127_4704460_11 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000006075 164.0
PYH2_k127_4704460_12 Arginine-tRNA-protein transferase, N terminus K21420 - 2.3.2.29 0.0000000000000000000000000000000000000002118 158.0
PYH2_k127_4704460_13 - - - - 0.000000000000000000000000000000000001333 145.0
PYH2_k127_4704460_2 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008126 474.0
PYH2_k127_4704460_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240,K00245 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 411.0
PYH2_k127_4704460_4 ATP synthase subunit J K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 398.0
PYH2_k127_4704460_5 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 329.0
PYH2_k127_4704460_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001153 235.0
PYH2_k127_4704460_7 PFAM TrkA-N domain protein K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000001964 231.0
PYH2_k127_4704460_8 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000000000000000000000000000000000000000000001004 222.0
PYH2_k127_4704460_9 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000002011 173.0
PYH2_k127_4716611_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 521.0
PYH2_k127_4770361_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 524.0
PYH2_k127_4770361_1 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 384.0
PYH2_k127_4770361_2 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 295.0
PYH2_k127_4770361_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000005173 210.0
PYH2_k127_4783461_0 CO-methylating acetyl-CoA synthase activity K00193,K14138 - 2.3.1.169 1.6e-263 831.0
PYH2_k127_4783461_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 4.174e-220 691.0
PYH2_k127_4783461_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 1.246e-199 637.0
PYH2_k127_4783461_3 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 487.0
PYH2_k127_4783461_4 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 370.0
PYH2_k127_4783461_5 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 355.0
PYH2_k127_4783461_6 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 343.0
PYH2_k127_4783461_7 Putative diguanylate phosphodiesterase - - - 0.00002191 47.0
PYH2_k127_4788205_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 2.688e-279 874.0
PYH2_k127_4788205_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 425.0
PYH2_k127_4788205_10 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000001439 159.0
PYH2_k127_4788205_11 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000786 132.0
PYH2_k127_4788205_12 Peptidase family M48 - - - 0.0000000000000000000000002851 108.0
PYH2_k127_4788205_13 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000165 64.0
PYH2_k127_4788205_14 gag-polyprotein putative aspartyl protease K06985 - - 0.00002518 55.0
PYH2_k127_4788205_2 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 381.0
PYH2_k127_4788205_3 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 358.0
PYH2_k127_4788205_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 357.0
PYH2_k127_4788205_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 327.0
PYH2_k127_4788205_6 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 318.0
PYH2_k127_4788205_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008912 254.0
PYH2_k127_4788205_8 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000002535 219.0
PYH2_k127_4788205_9 - - - - 0.00000000000000000000000000000000000000000000000000002034 196.0
PYH2_k127_4788553_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 585.0
PYH2_k127_4788553_1 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 477.0
PYH2_k127_4788553_10 DNA-binding transcription factor activity K03655,K03892,K21903 - 3.6.4.12 0.0000000000000000000003889 99.0
PYH2_k127_4788553_11 Rhodanese Homology Domain - - - 0.00000000007775 68.0
PYH2_k127_4788553_12 Rhodanese Homology Domain - - - 0.000001232 50.0
PYH2_k127_4788553_2 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 311.0
PYH2_k127_4788553_3 ROK family K00845,K13967,K19979,K20433 - 2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001228 258.0
PYH2_k127_4788553_4 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000004079 235.0
PYH2_k127_4788553_5 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000001577 214.0
PYH2_k127_4788553_6 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000000000000000000000000000112 227.0
PYH2_k127_4788553_7 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.0000000000000000000000000000000000004239 152.0
PYH2_k127_4788553_8 - - - - 0.000000000000000000000003807 107.0
PYH2_k127_4788553_9 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000005308 105.0
PYH2_k127_4818092_0 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 561.0
PYH2_k127_4818092_1 Carbon-nitrogen hydrolase K13566 - 3.5.1.3 0.0000000000000000000000000000000000000000000000000000008832 201.0
PYH2_k127_4818092_2 Membrane - - - 0.00000000002429 72.0
PYH2_k127_4818092_3 Tetratricopeptide repeat - - - 0.00000006898 63.0
PYH2_k127_4853016_0 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 302.0
PYH2_k127_4853016_1 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000009123 168.0
PYH2_k127_4853016_3 Belongs to the UPF0235 family K09131 - - 0.000000000000003436 78.0
PYH2_k127_4853016_4 - - - - 0.0000906 49.0
PYH2_k127_4865226_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 494.0
PYH2_k127_4865226_1 PFAM 4Fe-4S K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 441.0
PYH2_k127_4865226_2 TrkA-N domain K03455,K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006788 274.0
PYH2_k127_4865226_3 Cytochrome c - - - 0.0000000000000000000000000001917 114.0
PYH2_k127_4874085_0 carbamoyl transferase, NodU family K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 407.0
PYH2_k127_4874085_1 TIGRFAM methyltransferase FkbM family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005941 285.0
PYH2_k127_495788_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.77e-199 629.0
PYH2_k127_495788_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 1.039e-195 618.0
PYH2_k127_495788_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 321.0
PYH2_k127_495788_3 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009684 305.0
PYH2_k127_495788_4 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001164 255.0
PYH2_k127_495788_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000001882 229.0
PYH2_k127_495788_6 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000003947 202.0
PYH2_k127_495788_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000003533 134.0
PYH2_k127_495788_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000002221 67.0
PYH2_k127_4990703_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 557.0
PYH2_k127_4990703_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 542.0
PYH2_k127_4990703_10 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000000000004069 163.0
PYH2_k127_4990703_11 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000000002801 113.0
PYH2_k127_4990703_12 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000006368 114.0
PYH2_k127_4990703_13 Cyclic nucleotide-monophosphate binding domain K04739 GO:0000003,GO:0000166,GO:0000226,GO:0000280,GO:0001704,GO:0001707,GO:0001932,GO:0001933,GO:0001934,GO:0002682,GO:0002683,GO:0002694,GO:0002695,GO:0003006,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0005952,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006469,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007017,GO:0007049,GO:0007143,GO:0007154,GO:0007162,GO:0007163,GO:0007165,GO:0007267,GO:0007268,GO:0007274,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007369,GO:0007389,GO:0007498,GO:0007507,GO:0007591,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007613,GO:0007635,GO:0008103,GO:0008150,GO:0008152,GO:0008283,GO:0008285,GO:0008306,GO:0008355,GO:0008603,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009798,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0010721,GO:0010927,GO:0010948,GO:0014706,GO:0014855,GO:0016020,GO:0016043,GO:0016310,GO:0016325,GO:0017076,GO:0019207,GO:0019210,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019932,GO:0019933,GO:0019935,GO:0019953,GO:0021700,GO:0022402,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023057,GO:0030029,GO:0030036,GO:0030104,GO:0030154,GO:0030155,GO:0030234,GO:0030239,GO:0030291,GO:0030551,GO:0030552,GO:0030554,GO:0030951,GO:0030952,GO:0031032,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031594,GO:0031625,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032878,GO:0032944,GO:0032945,GO:0032989,GO:0032991,GO:0033002,GO:0033043,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035265,GO:0035556,GO:0036094,GO:0036211,GO:0040007,GO:0040020,GO:0042048,GO:0042060,GO:0042127,GO:0042129,GO:0042130,GO:0042221,GO:0042303,GO:0042325,GO:0042326,GO:0042327,GO:0042493,GO:0042592,GO:0042692,GO:0042802,GO:0042995,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043412,GO:0043434,GO:0043549,GO:0043900,GO:0043901,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044441,GO:0044444,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044853,GO:0045121,GO:0045202,GO:0045214,GO:0045471,GO:0045595,GO:0045596,GO:0045786,GO:0045835,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046006,GO:0046007,GO:0046677,GO:0048285,GO:0048332,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048589,GO:0048598,GO:0048599,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048856,GO:0048869,GO:0048871,GO:0048878,GO:0050670,GO:0050672,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050817,GO:0050863,GO:0050865,GO:0050866,GO:0050868,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051249,GO:0051250,GO:0051252,GO:0051321,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051447,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0055001,GO:0055002,GO:0055017,GO:0060038,GO:0060255,GO:0060259,GO:0060281,GO:0060283,GO:0060284,GO:0060419,GO:0060537,GO:0061061,GO:0061695,GO:0065007,GO:0065008,GO:0065009,GO:0070663,GO:0070664,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072359,GO:0072375,GO:0080090,GO:0090036,GO:0090038,GO:0097159,GO:0097305,GO:0097367,GO:0097435,GO:0097546,GO:0098589,GO:0098590,GO:0098772,GO:0098805,GO:0098857,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:0120038,GO:0140013,GO:1900193,GO:1900194,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902532,GO:1902911,GO:1903037,GO:1903038,GO:1903046,GO:1903429,GO:1903430,GO:1903506,GO:1903538,GO:1905879,GO:1905880,GO:1990234,GO:2000112,GO:2000114,GO:2000241,GO:2000242,GO:2000253,GO:2000479,GO:2000480,GO:2001141 - 0.000000000008029 76.0
PYH2_k127_4990703_2 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 385.0
PYH2_k127_4990703_3 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 323.0
PYH2_k127_4990703_4 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 321.0
PYH2_k127_4990703_5 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 324.0
PYH2_k127_4990703_6 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 296.0
PYH2_k127_4990703_7 High-affinity branched-chain amino acid transport protein (ABC superfamily K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007588 283.0
PYH2_k127_4990703_8 pfam abc K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007279 265.0
PYH2_k127_4990703_9 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000002892 186.0
PYH2_k127_5032216_0 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 487.0
PYH2_k127_5032216_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 336.0
PYH2_k127_5032216_2 cytochrome complex assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006742 251.0
PYH2_k127_5036234_0 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 489.0
PYH2_k127_5036234_1 Beta-eliminating lyase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 361.0
PYH2_k127_5036234_2 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004078 271.0
PYH2_k127_5036234_3 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000001529 256.0
PYH2_k127_5036234_4 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000001124 256.0
PYH2_k127_5036234_5 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000000000000000002852 190.0
PYH2_k127_5036234_6 LemA family K03744 - - 0.000000000000000000000000000000000000000000000005403 177.0
PYH2_k127_5036234_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000006562 119.0
PYH2_k127_5053995_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 492.0
PYH2_k127_5053995_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001576 280.0
PYH2_k127_5053995_2 - - - - 0.000000000000000000000000000000000000003054 154.0
PYH2_k127_5053995_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000003929 57.0
PYH2_k127_5053995_4 - - - - 0.0003777 48.0
PYH2_k127_5121770_0 Capsular polysaccharide biosynthesis protein K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000008399 180.0
PYH2_k127_5121770_1 Lipid A core-O-antigen ligase-like enyme K18814 - - 0.000000000000000000005073 101.0
PYH2_k127_5121770_2 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000685 74.0
PYH2_k127_5188728_0 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001783 296.0
PYH2_k127_5225646_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 2.188e-259 807.0
PYH2_k127_5225646_1 Carboxyl transferase domain K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006982 338.0
PYH2_k127_5225646_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000008017 201.0
PYH2_k127_5230249_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 307.0
PYH2_k127_5230249_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000001322 201.0
PYH2_k127_5230249_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000002418 195.0
PYH2_k127_5230249_3 PSP1 C-terminal domain protein - - - 0.0000002747 55.0
PYH2_k127_5294734_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 531.0
PYH2_k127_5294734_1 PFAM Glycosyl transferase family 2 K12984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 355.0
PYH2_k127_5294734_2 carbamoyl transferase, NodU family K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 332.0
PYH2_k127_5294734_3 Pfam Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000007774 228.0
PYH2_k127_5294734_4 DREV methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000001084 155.0
PYH2_k127_5322913_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 578.0
PYH2_k127_5322913_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 526.0
PYH2_k127_5322913_2 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 433.0
PYH2_k127_5322913_3 Pyruvate kinase, alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 392.0
PYH2_k127_5322913_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000008941 210.0
PYH2_k127_5322913_5 HNH nucleases - - - 0.00000000000000000000000000000000000000001048 156.0
PYH2_k127_5322913_6 methyltransferase activity - - - 0.0000000000000000000000000000000000000189 149.0
PYH2_k127_5322913_7 - - - - 0.00000000001941 66.0
PYH2_k127_5325235_0 TIGRFAM Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 578.0
PYH2_k127_5325235_1 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 414.0
PYH2_k127_5325235_2 TonB dependent receptor K16090 - - 0.00008495 50.0
PYH2_k127_5337541_0 - - - - 0.00000000000000000000000000000000000000000000000000000001721 201.0
PYH2_k127_5337541_1 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000003853 182.0
PYH2_k127_5350118_0 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000006696 184.0
PYH2_k127_5350118_1 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000027 147.0
PYH2_k127_5350118_2 SMART ATP-binding region ATPase domain protein K03406,K07710 - 2.7.13.3 0.000000000002093 80.0
PYH2_k127_5467901_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 502.0
PYH2_k127_5467901_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 429.0
PYH2_k127_5467901_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 307.0
PYH2_k127_5489149_0 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 509.0
PYH2_k127_5489149_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 452.0
PYH2_k127_5489149_2 Ribonuclease R winged-helix domain K09720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 373.0
PYH2_k127_5489149_3 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000009825 177.0
PYH2_k127_5489149_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000002785 100.0
PYH2_k127_5490944_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 3.513e-295 926.0
PYH2_k127_5490944_1 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009563 336.0
PYH2_k127_5490944_10 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000005825 50.0
PYH2_k127_5490944_2 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 314.0
PYH2_k127_5490944_3 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 301.0
PYH2_k127_5490944_4 Phosphonate ABC transporter, periplasmic K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 293.0
PYH2_k127_5490944_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000288 283.0
PYH2_k127_5490944_6 CHASE K02488,K21009 - 2.7.7.65 0.0000000000000000000000000000000000000000002035 181.0
PYH2_k127_5490944_7 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000000007384 121.0
PYH2_k127_5490944_8 DUF218 domain - - - 0.000000000000000000000001523 112.0
PYH2_k127_5490944_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000003946 87.0
PYH2_k127_550660_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 436.0
PYH2_k127_550660_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000008709 180.0
PYH2_k127_550660_2 - - - - 0.00000000000000000000001569 105.0
PYH2_k127_550660_3 thiamine diphosphate biosynthetic process K03154 - - 0.0000000000005019 72.0
PYH2_k127_5524695_0 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 580.0
PYH2_k127_5524695_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 565.0
PYH2_k127_5524695_2 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000008882 232.0
PYH2_k127_5524695_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000005712 178.0
PYH2_k127_5524695_4 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000004649 122.0
PYH2_k127_5529276_0 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 447.0
PYH2_k127_5529276_1 Uncharacterised protein family (UPF0158) - - - 0.000000006656 65.0
PYH2_k127_5529276_2 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000007603 59.0
PYH2_k127_5554632_0 His Kinase A (phosphoacceptor) domain - - - 1.329e-246 781.0
PYH2_k127_5554632_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000874 226.0
PYH2_k127_5554632_2 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000009159 191.0
PYH2_k127_5614219_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1163.0
PYH2_k127_5614219_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 516.0
PYH2_k127_5614219_10 protein homooligomerization - - - 0.0001993 51.0
PYH2_k127_5614219_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 452.0
PYH2_k127_5614219_3 PFAM PfkB K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 378.0
PYH2_k127_5614219_4 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002347 271.0
PYH2_k127_5614219_5 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000001284 202.0
PYH2_k127_5614219_6 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000002818 144.0
PYH2_k127_5614219_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000001426 125.0
PYH2_k127_5614219_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000004047 73.0
PYH2_k127_5614219_9 tail specific protease K03797 - 3.4.21.102 0.0000000002542 62.0
PYH2_k127_5638874_0 PFAM ATP-binding region ATPase domain protein - - - 1.189e-271 863.0
PYH2_k127_5638874_1 HD domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 465.0
PYH2_k127_5638874_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009559 386.0
PYH2_k127_5638874_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 323.0
PYH2_k127_5638874_4 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 289.0
PYH2_k127_5638874_5 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003476 243.0
PYH2_k127_5638874_6 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000001357 237.0
PYH2_k127_5638874_7 Belongs to the anti-sigma-factor antagonist family - - - 0.00000000000000000000004527 104.0
PYH2_k127_5638874_8 Histidine kinase-like ATPase domain - - - 0.000000002822 67.0
PYH2_k127_5661183_0 CobB/CobQ-like glutamine amidotransferase domain K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 523.0
PYH2_k127_5661183_1 Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L- methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by K22466 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 516.0
PYH2_k127_5661183_10 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001572 263.0
PYH2_k127_5661183_11 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000003694 203.0
PYH2_k127_5661183_12 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000009313 153.0
PYH2_k127_5661183_13 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000005603 103.0
PYH2_k127_5661183_14 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000002785 100.0
PYH2_k127_5661183_15 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000005612 100.0
PYH2_k127_5661183_16 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000004652 96.0
PYH2_k127_5661183_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 465.0
PYH2_k127_5661183_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 415.0
PYH2_k127_5661183_4 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 414.0
PYH2_k127_5661183_5 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 322.0
PYH2_k127_5661183_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 314.0
PYH2_k127_5661183_7 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 303.0
PYH2_k127_5661183_8 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 299.0
PYH2_k127_5661183_9 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000004312 265.0
PYH2_k127_5671687_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 1.064e-235 736.0
PYH2_k127_5671687_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 445.0
PYH2_k127_5671687_2 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000000000002028 220.0
PYH2_k127_5671687_3 Nitrogen regulatory protein P-II K04751 - - 0.0000000000000000000000000000000000000000000000000003042 187.0
PYH2_k127_5706644_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 591.0
PYH2_k127_5706644_1 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 490.0
PYH2_k127_5706644_2 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 386.0
PYH2_k127_5706644_3 Belongs to the HesB IscA family K15724 - - 0.000000000000000000000000000006989 121.0
PYH2_k127_5709450_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 529.0
PYH2_k127_5709450_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 418.0
PYH2_k127_5709450_2 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000001653 271.0
PYH2_k127_5709450_3 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000002033 209.0
PYH2_k127_5709450_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000004626 133.0
PYH2_k127_5728937_0 Acetyl-coenzyme A transporter 1 K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 481.0
PYH2_k127_5728937_1 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000009682 169.0
PYH2_k127_5744078_0 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 462.0
PYH2_k127_5744078_1 zinc-ribbon domain - - - 0.000001468 55.0
PYH2_k127_5749359_0 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 445.0
PYH2_k127_5749359_1 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 330.0
PYH2_k127_5749359_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 302.0
PYH2_k127_5771875_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 522.0
PYH2_k127_5771875_1 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 499.0
PYH2_k127_5771875_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 479.0
PYH2_k127_5771875_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 353.0
PYH2_k127_5771875_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 309.0
PYH2_k127_5771875_5 PFAM Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 304.0
PYH2_k127_5771875_6 - - - - 0.00000000000000000000000000000000000000000000000000000001686 205.0
PYH2_k127_5771875_7 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000003173 165.0
PYH2_k127_5831993_0 acetyl-CoA hydrolase K18288 - - 1.321e-215 687.0
PYH2_k127_5831993_1 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 335.0
PYH2_k127_5831993_2 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 295.0
PYH2_k127_5831993_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000776 258.0
PYH2_k127_5831993_4 oxidoreductase K10960 - 1.3.1.111,1.3.1.83 0.000000000000000000000000000000000000000000000000000000000000000001443 243.0
PYH2_k127_5831993_5 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000001862 162.0
PYH2_k127_5831993_6 Universal stress protein family - - - 0.0000000000000000000000000000000000000001173 155.0
PYH2_k127_5831993_7 proteolysis K03665 - - 0.000000000000000000000000000281 121.0
PYH2_k127_5843812_0 Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 490.0
PYH2_k127_5843812_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 324.0
PYH2_k127_5843812_2 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000009237 205.0
PYH2_k127_5843812_3 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.000000000000000000000000000008293 123.0
PYH2_k127_5843812_4 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000002988 95.0
PYH2_k127_5843812_5 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00000000000004069 74.0
PYH2_k127_5843812_6 Nitrate reductase delta subunit - - - 0.000004593 55.0
PYH2_k127_5908677_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 547.0
PYH2_k127_5908677_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 309.0
PYH2_k127_5908677_2 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000005326 201.0
PYH2_k127_5908677_3 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000001179 202.0
PYH2_k127_5908677_4 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000005129 82.0
PYH2_k127_5911055_0 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 453.0
PYH2_k127_5911055_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 434.0
PYH2_k127_5911055_2 HAMP domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000004183 201.0
PYH2_k127_5920247_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 5.326e-195 614.0
PYH2_k127_5920247_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 376.0
PYH2_k127_5920247_2 Fumarate hydratase (Fumerase) K01676,K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002624 276.0
PYH2_k127_5920247_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000003536 232.0
PYH2_k127_5920247_4 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000004779 210.0
PYH2_k127_5920247_5 AMP binding - - - 0.00000000000000000000000000000009971 129.0
PYH2_k127_5920247_6 DeoR-like helix-turn-helix domain - - - 0.000000000000000000000000000001143 132.0
PYH2_k127_5920247_7 - - - - 0.000000000000000006633 92.0
PYH2_k127_5920247_8 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000008966 61.0
PYH2_k127_5943208_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 430.0
PYH2_k127_5943208_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00005234 55.0
PYH2_k127_5943208_2 Universal stress protein K06149 - - 0.0000691 53.0
PYH2_k127_5962421_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.274e-305 960.0
PYH2_k127_6017790_0 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008472 472.0
PYH2_k127_6017790_1 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 422.0
PYH2_k127_6017790_2 PFAM VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000001956 226.0
PYH2_k127_6017790_3 - - - - 0.00000000000001249 80.0
PYH2_k127_6037396_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.032e-222 696.0
PYH2_k127_6037396_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 472.0
PYH2_k127_6037396_2 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 462.0
PYH2_k127_6037396_3 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 471.0
PYH2_k127_6037396_4 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 318.0
PYH2_k127_6037396_5 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 327.0
PYH2_k127_6037396_6 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 313.0
PYH2_k127_6037396_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002469 241.0
PYH2_k127_6037396_8 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000008765 145.0
PYH2_k127_6055752_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 332.0
PYH2_k127_6055752_1 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000000000001015 173.0
PYH2_k127_6064339_0 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 288.0
PYH2_k127_6064339_1 Domain of unknown function (DUF296) - - - 0.00000000000000000000000000000000000000000000000000000005579 198.0
PYH2_k127_6064339_2 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.000000000000000000000000000000000000000003821 166.0
PYH2_k127_6064339_3 peptidyl-tyrosine sulfation - - - 0.0000000000000000000002826 103.0
PYH2_k127_6165174_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.07e-273 857.0
PYH2_k127_6165174_1 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 540.0
PYH2_k127_6165174_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000005013 271.0
PYH2_k127_6165174_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000006644 260.0
PYH2_k127_6165174_4 glycolate biosynthetic process K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000003005 247.0
PYH2_k127_6165174_5 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000008642 52.0
PYH2_k127_6176683_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 3.634e-280 877.0
PYH2_k127_6176683_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 9.045e-220 696.0
PYH2_k127_6176683_10 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001725 254.0
PYH2_k127_6176683_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000009676 246.0
PYH2_k127_6176683_12 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000001768 245.0
PYH2_k127_6176683_13 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000402 203.0
PYH2_k127_6176683_14 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000526 169.0
PYH2_k127_6176683_15 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000005572 153.0
PYH2_k127_6176683_16 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000000000000000000000000000001507 151.0
PYH2_k127_6176683_17 MgtC family K07507 - - 0.000000000000000000000000000000000000001574 155.0
PYH2_k127_6176683_18 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000000000001035 143.0
PYH2_k127_6176683_19 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000001295 124.0
PYH2_k127_6176683_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 505.0
PYH2_k127_6176683_20 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.0000000000000000000000000003031 122.0
PYH2_k127_6176683_21 - - - - 0.000000000000000000000009243 104.0
PYH2_k127_6176683_22 - - - - 0.00000000000000000000008889 100.0
PYH2_k127_6176683_23 energy transducer activity K03646,K03832 - - 0.00000000000001072 83.0
PYH2_k127_6176683_3 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 372.0
PYH2_k127_6176683_4 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 358.0
PYH2_k127_6176683_5 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 337.0
PYH2_k127_6176683_6 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 328.0
PYH2_k127_6176683_7 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 323.0
PYH2_k127_6176683_8 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 295.0
PYH2_k127_6176683_9 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005848 272.0
PYH2_k127_6405749_0 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 459.0
PYH2_k127_6405749_1 4Fe-4S binding domain - - - 0.0000000000000000000000000000000001775 134.0
PYH2_k127_6405749_2 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000003738 56.0
PYH2_k127_6436191_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 456.0
PYH2_k127_6436191_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 424.0
PYH2_k127_6436191_2 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 355.0
PYH2_k127_6436191_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000002761 245.0
PYH2_k127_6436191_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000002763 112.0
PYH2_k127_6548808_0 AcrB/AcrD/AcrF family K03296,K18138 - - 2.02e-212 665.0
PYH2_k127_6548808_1 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 546.0
PYH2_k127_6548808_2 GAF domain K02584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 541.0
PYH2_k127_6548808_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000003427 192.0
PYH2_k127_6548808_4 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000008851 166.0
PYH2_k127_6548808_5 DinB family - - - 0.000000000000000000000000000000002007 139.0
PYH2_k127_6548808_6 PFAM RNA recognition motif - - - 0.000000000000000000000000004259 113.0
PYH2_k127_6548808_7 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000001111 55.0
PYH2_k127_6551418_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 534.0
PYH2_k127_6551418_1 Competence protein K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 348.0
PYH2_k127_6551418_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 331.0
PYH2_k127_6551418_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 323.0
PYH2_k127_6551418_4 YbbR-like protein - - - 0.00000000000000000000000000000000005883 142.0
PYH2_k127_6551418_5 DNA excision K02806 - - 0.0000000002756 63.0
PYH2_k127_660592_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 8.448e-195 619.0
PYH2_k127_660592_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 315.0
PYH2_k127_660592_10 peptidyl-tyrosine sulfation - - - 0.000005357 58.0
PYH2_k127_660592_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000002443 230.0
PYH2_k127_660592_3 - - - - 0.000000000000000000000000000000000000000000000000000001174 215.0
PYH2_k127_660592_4 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000002244 160.0
PYH2_k127_660592_5 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000009934 147.0
PYH2_k127_660592_6 Hydrolase, P-loop family K06925 - - 0.0000000000000000000000000000000005363 135.0
PYH2_k127_660592_7 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000001698 91.0
PYH2_k127_660592_8 LysM domain - - - 0.0000000001727 74.0
PYH2_k127_660592_9 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - 0.0000007036 62.0
PYH2_k127_6637744_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 2.285e-305 944.0
PYH2_k127_6637744_1 Tripartite tricarboxylate transporter TctA family K07793 - - 1.16e-238 752.0
PYH2_k127_6637744_2 4Fe-4S double cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008104 318.0
PYH2_k127_6637744_3 S1 domain K00243 - - 0.00000000000000000000000000000000000000001231 168.0
PYH2_k127_6637744_4 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000002364 144.0
PYH2_k127_6637744_5 - - - - 0.0000000000000000000000000001437 121.0
PYH2_k127_6637744_6 - - - - 0.000000000006074 68.0
PYH2_k127_6678073_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 4.003e-196 635.0
PYH2_k127_6678073_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008151 365.0
PYH2_k127_6678073_2 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000001926 173.0
PYH2_k127_6678073_3 epimerase dehydratase K19997 - 5.1.3.26 0.00000000000000000000000000002235 119.0
PYH2_k127_6706539_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 455.0
PYH2_k127_6706539_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000005185 177.0
PYH2_k127_6706539_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000005491 170.0
PYH2_k127_6706539_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000005554 108.0
PYH2_k127_6731649_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 587.0
PYH2_k127_6731649_1 RDD family - - - 0.000000000000000000000000000000004173 132.0
PYH2_k127_6749677_0 DEAD DEAH box helicase K06877 - - 7.895e-221 708.0
PYH2_k127_6749677_1 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000001349 174.0
PYH2_k127_6749677_2 response to copper ion K07156,K14166 - - 0.00000000000000000000000000000002532 131.0
PYH2_k127_6749677_3 protein-disulfide reductase activity - - - 0.0000000000000000000000003852 111.0
PYH2_k127_6749677_4 response to copper ion - - - 0.00000000000000000006331 105.0
PYH2_k127_6749677_5 - - - - 0.00000000000002992 72.0
PYH2_k127_6749677_6 Copper resistance protein D K07245 - - 0.00000000000003185 86.0
PYH2_k127_6807854_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 585.0
PYH2_k127_6807854_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 392.0
PYH2_k127_6807854_2 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 391.0
PYH2_k127_6807854_3 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 375.0
PYH2_k127_6807854_4 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 312.0
PYH2_k127_6807854_5 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 287.0
PYH2_k127_6807854_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000002772 273.0
PYH2_k127_6807854_7 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000001912 139.0
PYH2_k127_6814767_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.28e-246 774.0
PYH2_k127_6814767_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 405.0
PYH2_k127_6814767_2 - - - - 0.000000000000000000002359 102.0
PYH2_k127_6828198_0 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000001848 251.0
PYH2_k127_6828198_1 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000002132 218.0
PYH2_k127_6828198_2 Belongs to the UPF0502 family K09915 - - 0.000000000000000000000000000000000000000000000000000000000006116 215.0
PYH2_k127_6828198_3 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000000001082 199.0
PYH2_k127_6828198_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000003025 162.0
PYH2_k127_6828198_5 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000000001432 151.0
PYH2_k127_6828198_6 FabA-like domain K02372 - 4.2.1.59 0.0000000000000000000000001514 111.0
PYH2_k127_6828198_7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000005738 87.0
PYH2_k127_6853445_0 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 497.0
PYH2_k127_6853445_1 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 385.0
PYH2_k127_6853445_2 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 335.0
PYH2_k127_6853445_4 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000005294 68.0
PYH2_k127_6853445_5 - - - - 0.0000001614 58.0
PYH2_k127_68680_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 401.0
PYH2_k127_68680_1 PLD-like domain K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003866 262.0
PYH2_k127_68680_2 Zinc dependent phospholipase C - - - 0.00000000000000000000000000000000000000000000000000001042 198.0
PYH2_k127_68680_3 HAD-superfamily hydrolase subfamily IA, variant 3 K07025 - - 0.0000000000000000000000000000000000000000000000000001561 193.0
PYH2_k127_68680_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000007164 142.0
PYH2_k127_68680_5 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000253 72.0
PYH2_k127_68680_6 PFAM DsrE family protein - - - 0.000002003 55.0
PYH2_k127_6879721_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.779e-261 816.0
PYH2_k127_6879721_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 329.0
PYH2_k127_6879721_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000002649 166.0
PYH2_k127_6879721_3 Transcriptional regulatory protein, C terminal K07670 - - 0.00000000000000000009346 93.0
PYH2_k127_6889686_0 Elongation factor SelB, winged helix K03833 - - 2.266e-202 647.0
PYH2_k127_6889686_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 464.0
PYH2_k127_6889686_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 297.0
PYH2_k127_6889686_3 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000009475 156.0
PYH2_k127_6889686_5 protein N-acetylglucosaminyltransferase activity - - - 0.0000009259 61.0
PYH2_k127_6933231_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1202.0
PYH2_k127_6933231_1 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 304.0
PYH2_k127_6933231_2 PFAM PHP domain - - - 0.000000000000000000000000000000000000000002498 166.0
PYH2_k127_6933231_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000005458 93.0
PYH2_k127_6933231_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00001436 49.0
PYH2_k127_6944721_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 356.0
PYH2_k127_6944721_1 Belongs to the beta-ketoacyl-ACP synthases family K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000001134 208.0
PYH2_k127_6944721_2 Phosphopantetheine attachment site - - - 0.00000000000000000000009534 107.0
PYH2_k127_6944721_3 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000009169 55.0
PYH2_k127_6944721_4 Oxidoreductase, short chain dehydrogenase reductase family protein K00076,K05783 - 1.1.1.159,1.3.1.25 0.00001208 48.0
PYH2_k127_6973278_0 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000003029 169.0
PYH2_k127_6973278_1 TRAM domain K03215 - 2.1.1.190 0.000000000000000000000000000000000000000001715 167.0
PYH2_k127_6973278_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000002275 121.0
PYH2_k127_7058961_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007142 417.0
PYH2_k127_7058961_1 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000007419 191.0
PYH2_k127_7058961_2 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000002126 173.0
PYH2_k127_7058961_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000007631 171.0
PYH2_k127_7058961_4 PFAM DAHP synthetase I K01627 - 2.5.1.55 0.0000000000000000005584 87.0
PYH2_k127_707329_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.00000000000000000000000000000000000000000000000000000000000188 227.0
PYH2_k127_707329_1 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000144 154.0
PYH2_k127_707329_2 Universal stress protein family K07090 - - 0.0000000000000000000000000000000000009142 156.0
PYH2_k127_707329_3 mRNA catabolic process K18682 - - 0.000000000000000000255 90.0
PYH2_k127_7148660_0 MGS-like domain - - - 0.0000000000000000000000000000000000000000000000000867 185.0
PYH2_k127_7148660_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000273 181.0
PYH2_k127_7148660_2 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000008123 128.0
PYH2_k127_7178729_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 619.0
PYH2_k127_7178729_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 323.0
PYH2_k127_7178729_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000002892 63.0
PYH2_k127_7178729_5 integral membrane protein - - - 0.0000004717 55.0
PYH2_k127_7207415_0 phosphorelay signal transduction system K02584,K07713 - - 0.00000000000000000000000002878 113.0
PYH2_k127_7207415_1 May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine K10711 GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000003162 115.0
PYH2_k127_7207415_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000232 65.0
PYH2_k127_7338579_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 556.0
PYH2_k127_7338579_1 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 567.0
PYH2_k127_7338579_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000001732 180.0
PYH2_k127_7338579_3 adenylate kinase activity K00939,K01939 - 2.7.4.3,6.3.4.4 0.0001037 48.0
PYH2_k127_7348509_0 ATPase BadF BadG BcrA BcrD type - - - 0.0 1495.0
PYH2_k127_7352161_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.288e-261 829.0
PYH2_k127_7352161_1 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 345.0
PYH2_k127_7352161_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000001482 147.0
PYH2_k127_7364877_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0 1068.0
PYH2_k127_7364877_1 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335 - 1.6.5.3 7.999e-198 632.0
PYH2_k127_7364877_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 607.0
PYH2_k127_7364877_3 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 464.0
PYH2_k127_7364877_4 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 333.0
PYH2_k127_7364877_5 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000002746 142.0
PYH2_k127_7364877_6 cyclic nucleotide-binding - - - 0.000000000000000000000000000006723 125.0
PYH2_k127_736797_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 4.733e-280 884.0
PYH2_k127_736797_1 Glycosyl hydrolase family 57 - - - 8.84e-242 768.0
PYH2_k127_736797_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 499.0
PYH2_k127_736797_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 390.0
PYH2_k127_736797_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000622 172.0
PYH2_k127_736797_5 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000006405 148.0
PYH2_k127_736797_6 - - - - 0.00000000000000000000000000000000008611 151.0
PYH2_k127_736797_7 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.0000000000000000000002477 96.0
PYH2_k127_736797_8 cell cycle K05589,K12065,K13052 - - 0.0000000000000007831 81.0
PYH2_k127_7370875_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.544e-217 681.0
PYH2_k127_7370875_1 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 346.0
PYH2_k127_7370875_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000001228 241.0
PYH2_k127_7370875_3 ATPase (AAA K06923 - - 0.000000000000000000000000000000000000000000000000000000000000002498 228.0
PYH2_k127_7370875_4 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000003825 220.0
PYH2_k127_7370875_5 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000001036 177.0
PYH2_k127_7370875_6 retrograde transport, endosome to Golgi K07095 - - 0.000000000000000000000000000000000000000000008672 169.0
PYH2_k127_7370875_7 histidine kinase HAMP region domain protein - - - 0.0000000001389 73.0
PYH2_k127_7370875_8 PFAM aminotransferase, class I and II - - - 0.000006631 58.0
PYH2_k127_7425876_0 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 419.0
PYH2_k127_7425876_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 409.0
PYH2_k127_7425876_2 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000002005 260.0
PYH2_k127_7431774_0 Phosphoglycerate kinase K00927 - 2.7.2.3 5.533e-195 617.0
PYH2_k127_7431774_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009042 600.0
PYH2_k127_7431774_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000002575 232.0
PYH2_k127_7431774_11 metal ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000006798 230.0
PYH2_k127_7431774_12 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.0000000000000000000000000000000000000000000000000000000000273 208.0
PYH2_k127_7431774_13 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000003984 199.0
PYH2_k127_7431774_14 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000007703 174.0
PYH2_k127_7431774_15 Lysin motif - - - 0.0000000000000000000000000000000000000188 156.0
PYH2_k127_7431774_16 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000005625 136.0
PYH2_k127_7431774_17 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000004101 128.0
PYH2_k127_7431774_18 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000002003 115.0
PYH2_k127_7431774_19 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000006735 97.0
PYH2_k127_7431774_2 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 490.0
PYH2_k127_7431774_20 Protein of unknown function (DUF2845) - - - 0.000000000000005526 79.0
PYH2_k127_7431774_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009954 491.0
PYH2_k127_7431774_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007443 417.0
PYH2_k127_7431774_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 392.0
PYH2_k127_7431774_6 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 365.0
PYH2_k127_7431774_7 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 360.0
PYH2_k127_7431774_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 306.0
PYH2_k127_7431774_9 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000467 252.0
PYH2_k127_7439129_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 575.0
PYH2_k127_7439129_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 353.0
PYH2_k127_7439129_10 general secretion pathway protein K02459 - - 0.0000017 58.0
PYH2_k127_7439129_11 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.00008661 46.0
PYH2_k127_7439129_2 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 331.0
PYH2_k127_7439129_3 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000000000000000000000000000000354 229.0
PYH2_k127_7439129_4 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000000000000000207 197.0
PYH2_k127_7439129_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000001327 185.0
PYH2_k127_7439129_6 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000001876 134.0
PYH2_k127_7439129_7 PFAM RNA recognition motif - - - 0.000000000000000000000001108 106.0
PYH2_k127_7439129_8 TIGRFAM general secretion pathway protein H K02457 - - 0.00000005619 61.0
PYH2_k127_7439129_9 type IV pilus modification protein PilV K02458 - - 0.000001308 57.0
PYH2_k127_7509137_0 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 1.02e-202 649.0
PYH2_k127_7509137_1 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 506.0
PYH2_k127_7522917_0 COG0058 Glucan phosphorylase - - - 2.903e-255 797.0
PYH2_k127_7522917_1 Protein conserved in bacteria - - - 1.962e-234 753.0
PYH2_k127_7522917_10 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 322.0
PYH2_k127_7522917_11 phosphatase activity K20881 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003893 289.0
PYH2_k127_7522917_12 PFAM PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002728 273.0
PYH2_k127_7522917_13 Diguanylate cyclase, GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001316 269.0
PYH2_k127_7522917_14 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000004418 242.0
PYH2_k127_7522917_15 Tetratricopeptide repeat K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000006099 244.0
PYH2_k127_7522917_16 PFAM Cysteine-rich domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000003143 217.0
PYH2_k127_7522917_17 - - - - 0.0000000000000000000000000000000000000000000000000000000006166 211.0
PYH2_k127_7522917_18 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.000000000000000000000000000000000000000000000000000000006947 210.0
PYH2_k127_7522917_19 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000006598 168.0
PYH2_k127_7522917_2 PFAM magnesium chelatase ChlI subunit K07391 - - 1.481e-201 647.0
PYH2_k127_7522917_20 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000003198 160.0
PYH2_k127_7522917_22 Regulatory protein, FmdB family - - - 0.0000000000000003299 79.0
PYH2_k127_7522917_3 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 597.0
PYH2_k127_7522917_4 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 569.0
PYH2_k127_7522917_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 516.0
PYH2_k127_7522917_6 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 476.0
PYH2_k127_7522917_7 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005417 404.0
PYH2_k127_7522917_8 Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 340.0
PYH2_k127_7522917_9 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 326.0
PYH2_k127_7544717_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 7.19e-200 649.0
PYH2_k127_7544717_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000001666 194.0
PYH2_k127_7544717_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000005925 75.0
PYH2_k127_7561384_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 7.538e-196 634.0
PYH2_k127_7561384_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005884 349.0
PYH2_k127_7561384_2 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000005796 223.0
PYH2_k127_7561384_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 0.000000000000000000000000000000000000000000000001188 179.0
PYH2_k127_7561384_4 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000001172 157.0
PYH2_k127_7561384_5 Outer membrane lipoprotein - - - 0.000000000000000000000000000000002571 142.0
PYH2_k127_7561384_6 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000007523 87.0
PYH2_k127_7574047_0 Extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 459.0
PYH2_k127_7574047_1 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 447.0
PYH2_k127_7574047_2 histidine kinase A domain protein domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 447.0
PYH2_k127_7574047_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 364.0
PYH2_k127_7574047_4 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 355.0
PYH2_k127_7574047_5 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000001725 178.0
PYH2_k127_7578705_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 447.0
PYH2_k127_7578705_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 396.0
PYH2_k127_7578705_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 355.0
PYH2_k127_7578705_3 Beta-ketoacyl synthase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000001838 213.0
PYH2_k127_7578705_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000002208 81.0
PYH2_k127_7578705_5 Uncharacterized protein conserved in bacteria (DUF2062) - - - 0.00000000002112 71.0
PYH2_k127_7616943_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 610.0
PYH2_k127_7616943_1 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 604.0
PYH2_k127_7616943_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 435.0
PYH2_k127_7616943_3 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000008443 231.0
PYH2_k127_7616943_4 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000002198 198.0
PYH2_k127_7616943_5 Cytochrome c - - - 0.0000000000000000000000000000000000000000000003581 171.0
PYH2_k127_7616943_6 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000003479 147.0
PYH2_k127_7616943_7 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000003973 139.0
PYH2_k127_7627147_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008876 566.0
PYH2_k127_7627147_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000003624 219.0
PYH2_k127_7654543_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 7.592e-267 848.0
PYH2_k127_7654543_1 diguanylate cyclase K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000009043 271.0
PYH2_k127_7654543_2 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000002841 183.0
PYH2_k127_7654543_3 Protein of unknown function (DUF1318) - - - 0.00000000000000000000000000000000000000004941 159.0
PYH2_k127_7662934_0 Polysaccharide biosynthesis protein K17716 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 536.0
PYH2_k127_7662934_1 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 496.0
PYH2_k127_7662934_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008169 431.0
PYH2_k127_7662934_3 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007651 417.0
PYH2_k127_7662934_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 379.0
PYH2_k127_7662934_5 Glycosyltransferase, group 2 family protein K12992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 322.0
PYH2_k127_7662934_6 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 287.0
PYH2_k127_7662934_7 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 289.0
PYH2_k127_7662934_8 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 287.0
PYH2_k127_7662934_9 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002254 270.0
PYH2_k127_7696469_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 6.654e-230 724.0
PYH2_k127_7696469_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.986e-226 709.0
PYH2_k127_7696469_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000167 259.0
PYH2_k127_7696469_11 Domain of unknown function (DUF3488) - - - 0.0000000000000000000000000000000000000000000000000000000000006337 233.0
PYH2_k127_7696469_12 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000007368 157.0
PYH2_k127_7696469_13 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000001201 112.0
PYH2_k127_7696469_14 Polymer-forming cytoskeletal - - - 0.0000000000000000000000001234 110.0
PYH2_k127_7696469_15 Outer membrane lipoprotein Slp family K07285 - - 0.000000000000000000005855 98.0
PYH2_k127_7696469_2 5-formyltetrahydrofolate cyclo-ligase activity K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 597.0
PYH2_k127_7696469_3 TIGRFAM Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 501.0
PYH2_k127_7696469_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 467.0
PYH2_k127_7696469_5 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 431.0
PYH2_k127_7696469_6 ATPase associated with various cellular K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 328.0
PYH2_k127_7696469_7 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 325.0
PYH2_k127_7696469_8 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 286.0
PYH2_k127_7696469_9 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000339 275.0
PYH2_k127_769860_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 2.534e-209 676.0
PYH2_k127_769860_1 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 424.0
PYH2_k127_769860_2 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 375.0
PYH2_k127_769860_3 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003687 275.0
PYH2_k127_769860_4 Protein required for attachment to host cells - - - 0.00000000000000000000000000000002548 132.0
PYH2_k127_769860_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000004526 81.0
PYH2_k127_7699450_0 Tetratricopeptide repeat - - - 0.00000000000000000075 101.0
PYH2_k127_7699450_1 - - - - 0.00000000000000811 79.0
PYH2_k127_7700735_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1451.0
PYH2_k127_7700735_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182,K16239,K16874 - 4.1.1.61,4.1.1.98 2.051e-209 661.0
PYH2_k127_7700735_10 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000001208 268.0
PYH2_k127_7700735_11 4Fe-4S dicluster domain K03390,K16887 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000006173 237.0
PYH2_k127_7700735_12 'Cold-shock' DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000001097 219.0
PYH2_k127_7700735_13 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.00000000000000000000000000000000000000000000000004232 191.0
PYH2_k127_7700735_14 AI-2E family transporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000124 145.0
PYH2_k127_7700735_15 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.000000000000000000000000000000001326 131.0
PYH2_k127_7700735_16 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000006443 123.0
PYH2_k127_7700735_17 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000875 115.0
PYH2_k127_7700735_18 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000001303 115.0
PYH2_k127_7700735_19 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.00000000000000000000001502 106.0
PYH2_k127_7700735_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 491.0
PYH2_k127_7700735_20 antisigma factor binding K04749 - - 0.0000000000000000000015 98.0
PYH2_k127_7700735_21 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000001363 94.0
PYH2_k127_7700735_22 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.0000000000000000004493 88.0
PYH2_k127_7700735_23 PFAM Mammalian cell entry related K02067 - - 0.000000000000000008236 94.0
PYH2_k127_7700735_24 ABC-type transport auxiliary lipoprotein component K09857 - - 0.00000001375 63.0
PYH2_k127_7700735_25 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000005384 49.0
PYH2_k127_7700735_26 response regulator, receiver - - - 0.00001468 55.0
PYH2_k127_7700735_3 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 384.0
PYH2_k127_7700735_4 TrkA-N domain K03455,K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 366.0
PYH2_k127_7700735_5 CO dehydrogenase/acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 326.0
PYH2_k127_7700735_6 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 320.0
PYH2_k127_7700735_7 Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 289.0
PYH2_k127_7700735_8 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003295 273.0
PYH2_k127_7700735_9 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005998 270.0
PYH2_k127_7704475_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 571.0
PYH2_k127_7704475_1 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.000000000000000003633 89.0
PYH2_k127_7704475_2 ATPase (AAA superfamily K07133 - - 0.000000000002954 72.0
PYH2_k127_7745316_0 Dehydratase family K01687 - 4.2.1.9 2.149e-243 759.0
PYH2_k127_7772198_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 1.05e-255 798.0
PYH2_k127_7801586_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 6.655e-225 707.0
PYH2_k127_7801586_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 544.0
PYH2_k127_7801586_10 Thioredoxin K03672 - 1.8.1.8 0.00009782 53.0
PYH2_k127_7801586_2 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 530.0
PYH2_k127_7801586_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 521.0
PYH2_k127_7801586_4 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 332.0
PYH2_k127_7801586_5 zinc ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005677 262.0
PYH2_k127_7801586_6 competence protein - - - 0.00000000000000000000000000000000000000000000005098 178.0
PYH2_k127_7801586_7 Lysin motif K08307 - - 0.000000000000000000000000000416 119.0
PYH2_k127_7801586_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.000000000000000000001012 99.0
PYH2_k127_7801586_9 cell envelope organization K05807,K08309 - - 0.00000000000007318 81.0
PYH2_k127_7834359_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1668.0
PYH2_k127_7834359_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 606.0
PYH2_k127_7834359_2 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 548.0
PYH2_k127_7834359_3 Belongs to the bacterial glucokinase family K00845 GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 406.0
PYH2_k127_7834359_4 Sodium calcium exchanger membrane K07300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009936 389.0
PYH2_k127_7834359_5 Biotin-lipoyl like K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 360.0
PYH2_k127_7834359_6 Possible lysine decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000924 276.0
PYH2_k127_7834359_7 Ion channel - - - 0.00000000000000000000000000000000000003729 151.0
PYH2_k127_7835634_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001874 285.0
PYH2_k127_7835634_1 Kdo2-lipid A biosynthetic process K02517,K20543,K22311 - 2.3.1.241,2.3.1.265 0.000000000000000000000000000001565 130.0
PYH2_k127_7928320_0 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 518.0
PYH2_k127_7928320_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 413.0
PYH2_k127_7928320_10 DnaJ molecular chaperone homology domain - - - 0.000000003678 69.0
PYH2_k127_7928320_2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 388.0
PYH2_k127_7928320_3 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 387.0
PYH2_k127_7928320_4 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 346.0
PYH2_k127_7928320_5 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 336.0
PYH2_k127_7928320_6 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002496 253.0
PYH2_k127_7928320_7 ferrous iron binding K06990,K09141 - - 0.0000000000000000000000000000000000000000000000000000149 197.0
PYH2_k127_7928320_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000001005 166.0
PYH2_k127_7928320_9 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000004634 125.0
PYH2_k127_7930291_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.567e-284 896.0
PYH2_k127_7930291_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.587e-260 829.0
PYH2_k127_7930291_10 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000005206 93.0
PYH2_k127_7930291_11 Domain of unknown function (DUF4912) K09942 - - 0.0000000000004811 81.0
PYH2_k127_7930291_12 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000005594 63.0
PYH2_k127_7930291_13 Tetratricopeptide repeat - - - 0.0000002958 60.0
PYH2_k127_7930291_14 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives K02343 - 2.7.7.7 0.00004373 53.0
PYH2_k127_7930291_2 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 1.054e-237 750.0
PYH2_k127_7930291_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 610.0
PYH2_k127_7930291_4 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 597.0
PYH2_k127_7930291_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 321.0
PYH2_k127_7930291_6 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003157 277.0
PYH2_k127_7930291_7 Protein of unknown function (DUF2400) - - - 0.000000000000000000000000000000000000000000000000000000000000000000007719 243.0
PYH2_k127_7930291_8 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000001552 245.0
PYH2_k127_7930291_9 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000002828 141.0
PYH2_k127_8111370_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 2.033e-198 623.0
PYH2_k127_8111370_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 314.0
PYH2_k127_8111370_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000006752 171.0
PYH2_k127_8111370_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.0000000000000000542 81.0
PYH2_k127_8111370_4 tigr00255 - - - 0.000002452 51.0
PYH2_k127_8153381_0 S-adenosylhomocysteine deaminase activity K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 366.0
PYH2_k127_8153381_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000001392 237.0
PYH2_k127_8153381_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000004449 191.0
PYH2_k127_8153381_3 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000004244 137.0
PYH2_k127_8197612_0 'Cold-shock' DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000004799 221.0
PYH2_k127_8197612_1 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000001432 63.0
PYH2_k127_8197612_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07665 - - 0.00004439 54.0
PYH2_k127_829674_0 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 452.0
PYH2_k127_829674_1 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 393.0
PYH2_k127_8336857_0 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002149 249.0
PYH2_k127_8336857_1 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000313 190.0
PYH2_k127_8336857_2 membrane K00389 - - 0.0000000000000000000000000000000000000003485 153.0
PYH2_k127_8336857_3 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000002712 146.0
PYH2_k127_8404256_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.17e-233 736.0
PYH2_k127_8404256_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000007954 244.0
PYH2_k127_8404256_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000001935 222.0
PYH2_k127_8404256_3 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000001153 201.0
PYH2_k127_8404256_4 - - - - 0.000000000000000000000565 102.0
PYH2_k127_8404256_5 Catalyzes the conversion of dihydroorotate to orotate K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000002201 93.0
PYH2_k127_8432561_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1240.0
PYH2_k127_8432561_1 ABC transporter - - - 1.392e-230 719.0
PYH2_k127_8432561_10 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004186 254.0
PYH2_k127_8432561_11 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000000000000000000000008582 227.0
PYH2_k127_8432561_12 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000001391 204.0
PYH2_k127_8432561_13 Acyl dehydratase - - - 0.00000000000000000000000000000000000000000000000000000001106 201.0
PYH2_k127_8432561_14 - - - - 0.000000000000000000000000000000000000000000000000000000388 199.0
PYH2_k127_8432561_15 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000000002265 166.0
PYH2_k127_8432561_16 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000001062 160.0
PYH2_k127_8432561_17 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000003552 153.0
PYH2_k127_8432561_18 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000001484 159.0
PYH2_k127_8432561_19 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000001782 149.0
PYH2_k127_8432561_2 4Fe-4S binding domain - - - 4.866e-208 657.0
PYH2_k127_8432561_20 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000001491 124.0
PYH2_k127_8432561_21 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000005418 118.0
PYH2_k127_8432561_22 Protein of unknown function (DUF3592) - - - 0.000000000000000000000000001555 116.0
PYH2_k127_8432561_23 Universal stress protein family - - - 0.00000000000000000004092 101.0
PYH2_k127_8432561_24 Serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000005691 87.0
PYH2_k127_8432561_25 - - - - 0.00000001306 63.0
PYH2_k127_8432561_3 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 465.0
PYH2_k127_8432561_4 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 402.0
PYH2_k127_8432561_5 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 403.0
PYH2_k127_8432561_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 307.0
PYH2_k127_8432561_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004592 282.0
PYH2_k127_8432561_8 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000339 270.0
PYH2_k127_8432561_9 WYL domain K13573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001088 269.0
PYH2_k127_8445102_0 PFAM PhoH-like protein K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 608.0
PYH2_k127_8445102_1 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000486 447.0
PYH2_k127_8445102_2 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 287.0
PYH2_k127_8445102_3 Response regulator receiver domain - - - 0.00000000000000000000000134 115.0
PYH2_k127_8445102_4 Type I restriction enzyme R protein N terminus (HSDR_N) - - - 0.0000000000000000000003862 103.0
PYH2_k127_8461171_0 Aminotransferase class I and II K14261 - - 3.883e-205 643.0
PYH2_k127_8461171_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 522.0
PYH2_k127_8461171_10 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000002487 111.0
PYH2_k127_8461171_11 JAB/MPN domain K21140 - 3.13.1.6 0.00000000000000000000000308 106.0
PYH2_k127_8461171_12 sulfur carrier activity - - - 0.00000000000000000008195 91.0
PYH2_k127_8461171_2 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 366.0
PYH2_k127_8461171_3 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 365.0
PYH2_k127_8461171_4 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 335.0
PYH2_k127_8461171_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 314.0
PYH2_k127_8461171_6 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 301.0
PYH2_k127_8461171_7 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002709 265.0
PYH2_k127_8461171_8 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000000005231 218.0
PYH2_k127_8461171_9 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000000000000006127 202.0
PYH2_k127_8492115_0 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009327 529.0
PYH2_k127_8492115_1 4 iron, 4 sulfur cluster binding K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 399.0
PYH2_k127_8492115_10 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488,K13819 - - 0.0005067 45.0
PYH2_k127_8492115_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 397.0
PYH2_k127_8492115_3 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 325.0
PYH2_k127_8492115_4 sporulation initiation inhibitor protein Soj K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 310.0
PYH2_k127_8492115_5 membrane K09133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 315.0
PYH2_k127_8492115_6 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000007234 194.0
PYH2_k127_8492115_7 NTPase - - - 0.000000000000000000000000000000000000000014 161.0
PYH2_k127_8492115_8 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000002747 161.0
PYH2_k127_8492115_9 PFAM 4Fe-4S K00176 - 1.2.7.3 0.00000000000000001063 86.0
PYH2_k127_8509204_0 Transcriptional regulator K11921,K19338 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 378.0
PYH2_k127_8509204_1 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 337.0
PYH2_k127_8509204_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003584 280.0
PYH2_k127_8509204_3 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000000000001002 151.0
PYH2_k127_8509204_4 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000004693 77.0
PYH2_k127_8509204_6 - - - - 0.00002172 53.0
PYH2_k127_8525028_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000002281 272.0
PYH2_k127_8525028_1 PFAM blue (type 1) copper domain protein - - - 0.000000000000006469 79.0
PYH2_k127_8525028_2 Prokaryotic homologs of the JAB domain - - - 0.00006275 53.0
PYH2_k127_8547658_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.1e-253 790.0
PYH2_k127_8547658_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.133e-242 757.0
PYH2_k127_8547658_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 458.0
PYH2_k127_8547658_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 328.0
PYH2_k127_8547658_4 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 290.0
PYH2_k127_8547658_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000001199 151.0
PYH2_k127_8547658_6 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000004009 154.0
PYH2_k127_8547658_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000001599 144.0
PYH2_k127_8547658_8 SMART Tetratricopeptide - - - 0.000000000000006162 81.0
PYH2_k127_8547658_9 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000008658 59.0
PYH2_k127_8573131_0 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 449.0
PYH2_k127_8573131_1 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 395.0
PYH2_k127_8573131_10 membrane - - - 0.000000000000000000000000000006936 130.0
PYH2_k127_8573131_11 cheY-homologous receiver domain - - - 0.0000000000000000000000000001133 121.0
PYH2_k127_8573131_12 periplasmic ligand-binding sensor domain - - - 0.00000000000000000008845 106.0
PYH2_k127_8573131_13 Diguanylate cyclase - - - 0.00000005931 67.0
PYH2_k127_8573131_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001298 273.0
PYH2_k127_8573131_3 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001218 273.0
PYH2_k127_8573131_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000622 252.0
PYH2_k127_8573131_5 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000006406 213.0
PYH2_k127_8573131_6 DivIVA protein K04074 - - 0.0000000000000000000000000000000000000000000000000000000002294 206.0
PYH2_k127_8573131_7 HD domain - - - 0.00000000000000000000000000000000000000000000000000000006193 210.0
PYH2_k127_8573131_8 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000001231 172.0
PYH2_k127_8573131_9 YGGT family K02221 - - 0.0000000000000000000000000000000001519 137.0
PYH2_k127_8652568_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1028.0
PYH2_k127_8652568_1 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 6.406e-225 704.0
PYH2_k127_8652568_2 Phosphofructokinase K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 614.0
PYH2_k127_8652568_3 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 575.0
PYH2_k127_8718838_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.313e-238 744.0
PYH2_k127_8718838_1 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 399.0
PYH2_k127_8718838_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 321.0
PYH2_k127_8718838_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 303.0
PYH2_k127_8718838_4 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 305.0
PYH2_k127_8718838_5 nuclease K00590,K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 2.1.1.113,3.1.31.1 0.000000000000000000000000000000000000000000005968 170.0
PYH2_k127_8718838_6 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000001 139.0
PYH2_k127_8718838_7 Sporulation and spore germination - - - 0.0000000002673 68.0
PYH2_k127_8718838_8 cell wall hydrolase K01448 - 3.5.1.28 0.000000002422 69.0
PYH2_k127_8732785_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 595.0
PYH2_k127_8732785_1 Actin K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 529.0
PYH2_k127_8732785_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 344.0
PYH2_k127_8732785_3 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 325.0
PYH2_k127_8732785_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000004471 195.0
PYH2_k127_8732785_5 shape-determining protein MreC K03570 - - 0.0000000000000000000000000000000000000000001343 168.0
PYH2_k127_8732785_6 RDD family - - - 0.000000000000000000000000002802 115.0
PYH2_k127_8733260_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 4.34e-252 789.0
PYH2_k127_8733260_1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 370.0
PYH2_k127_8733260_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001406 263.0
PYH2_k127_8733260_3 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003163 255.0
PYH2_k127_8733260_4 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000005785 233.0
PYH2_k127_8733260_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K14080 - 2.1.1.246,4.1.1.37 0.00000000000000000000000000000001306 132.0
PYH2_k127_8733260_6 Domain of unknown function (DUF1858) - - - 0.0000000000000000002274 97.0
PYH2_k127_8733260_7 4Fe-4S binding domain - - - 0.00000003252 56.0
PYH2_k127_8733260_8 phosphorelay signal transduction system - - - 0.0001677 48.0
PYH2_k127_8778802_0 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 309.0
PYH2_k127_8778802_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 300.0
PYH2_k127_8778802_2 Telomere recombination K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003452 274.0
PYH2_k127_8778802_3 nickel cation binding K04651,K19640 - - 0.000000000000000000000000002423 118.0
PYH2_k127_8778802_4 YtxH-like protein - - - 0.000000000000000000000003739 111.0
PYH2_k127_8778802_5 Bacterial protein of unknown function (DUF948) - - - 0.000003514 54.0
PYH2_k127_8780018_0 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008353 251.0
PYH2_k127_8780018_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000007008 168.0
PYH2_k127_8780018_2 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000005533 150.0
PYH2_k127_8780018_3 COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog K03088 - - 0.0001542 50.0
PYH2_k127_8795662_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 493.0
PYH2_k127_8795662_1 PFAM peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 409.0
PYH2_k127_8795662_10 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) K00564,K15460 - 2.1.1.172,2.1.1.223 0.000000000000000000000000000000000000000000000000000174 191.0
PYH2_k127_8795662_11 Stringent starvation protein B K09985 - - 0.000000000000000000000000001629 124.0
PYH2_k127_8795662_12 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000001043 71.0
PYH2_k127_8795662_2 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 335.0
PYH2_k127_8795662_3 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 311.0
PYH2_k127_8795662_4 Belongs to the MurCDEF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 314.0
PYH2_k127_8795662_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000003846 225.0
PYH2_k127_8795662_6 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000000000000849 224.0
PYH2_k127_8795662_7 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000162 215.0
PYH2_k127_8795662_8 - K07039,K09933 - - 0.0000000000000000000000000000000000000000000000000000000000002411 222.0
PYH2_k127_8795662_9 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000002018 211.0
PYH2_k127_8803037_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 3.258e-214 674.0
PYH2_k127_8803037_1 Beta-Casp domain K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 509.0
PYH2_k127_8803037_2 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 387.0
PYH2_k127_8803037_3 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 375.0
PYH2_k127_8803037_4 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001595 254.0
PYH2_k127_8803037_5 NosL - - - 0.000000000000000000000000000000000000000002097 165.0
PYH2_k127_8803037_6 PFAM response regulator receiver - - - 0.00000001176 66.0
PYH2_k127_8809024_0 ABC transporter K06158 - - 7.071e-214 681.0
PYH2_k127_8809024_1 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 532.0
PYH2_k127_8809024_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000000000001202 148.0
PYH2_k127_8809024_11 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000001214 153.0
PYH2_k127_8809024_12 - - - - 0.00000000000000000000000000000000001348 139.0
PYH2_k127_8809024_13 HAMP domain - - - 0.000000000000000000000000000001481 137.0
PYH2_k127_8809024_14 PFAM Cold-shock protein, DNA-binding K03704 - - 0.000000000000000000000000553 110.0
PYH2_k127_8809024_16 DsrE/DsrF-like family - - - 0.0007658 47.0
PYH2_k127_8809024_2 TIGRFAM ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007598 490.0
PYH2_k127_8809024_3 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 342.0
PYH2_k127_8809024_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 303.0
PYH2_k127_8809024_5 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 294.0
PYH2_k127_8809024_6 Cation efflux family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002182 255.0
PYH2_k127_8809024_7 low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000944 167.0
PYH2_k127_8809024_8 Protein of unknown function (DUF1255) K09913 - 2.4.2.1,2.4.2.2 0.0000000000000000000000000000000000000000004994 159.0
PYH2_k127_8809024_9 Histidine kinase - - - 0.00000000000000000000000000000000000000007162 169.0
PYH2_k127_8819752_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 415.0
PYH2_k127_8819752_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000624 349.0
PYH2_k127_8819752_2 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006025 319.0
PYH2_k127_8819752_3 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001068 265.0
PYH2_k127_8819752_4 Beta-ketoacyl synthase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002268 248.0
PYH2_k127_8819752_5 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000000000000000000000000000003484 220.0
PYH2_k127_8819752_6 Domain of unknown function (DUF1992) - - - 0.00000000000000000000000000000002457 129.0
PYH2_k127_8819752_7 Putative methyltransferase - - - 0.000000000000000000000004138 116.0
PYH2_k127_8819752_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000004241 55.0
PYH2_k127_885603_0 Belongs to the helicase family. UvrD subfamily - - - 1.069e-204 672.0
PYH2_k127_885603_1 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007751 432.0
PYH2_k127_885603_2 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000001665 91.0
PYH2_k127_8878613_0 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 428.0
PYH2_k127_8878613_1 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 364.0
PYH2_k127_8878613_2 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 354.0
PYH2_k127_8878613_3 Methionine synthase, cobalamin (vitamin B12)-binding module, cap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 323.0
PYH2_k127_8878613_4 TIGRFAM iron-sulfur cluster binding protein - - - 0.0000000000000000000000000000000000000000000000003637 185.0
PYH2_k127_8896272_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.252e-216 708.0
PYH2_k127_8896272_1 Sigma-54 interaction domain K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 576.0
PYH2_k127_8896272_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 316.0
PYH2_k127_8896272_11 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000001898 263.0
PYH2_k127_8896272_13 PFAM CheW domain protein K03408 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002809 247.0
PYH2_k127_8896272_14 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000235 245.0
PYH2_k127_8896272_15 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006802 241.0
PYH2_k127_8896272_16 SCO1 SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000001731 233.0
PYH2_k127_8896272_17 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000000000000001342 222.0
PYH2_k127_8896272_18 Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.00000000000000000000000000000000000000000000000000002224 206.0
PYH2_k127_8896272_19 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000002108 186.0
PYH2_k127_8896272_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 552.0
PYH2_k127_8896272_20 PFAM chemotaxis K03406 - - 0.0000000000000000000000000000000000000000001753 164.0
PYH2_k127_8896272_21 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000000001732 163.0
PYH2_k127_8896272_22 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000000000000000000188 149.0
PYH2_k127_8896272_23 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000000000003491 132.0
PYH2_k127_8896272_24 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000006092 128.0
PYH2_k127_8896272_25 PFAM Archease protein family (DUF101 UPF0211) - - - 0.0000000000000000000000000001585 130.0
PYH2_k127_8896272_26 Thioesterase K07107 - - 0.0000000000000000000000000002691 119.0
PYH2_k127_8896272_27 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000003545 99.0
PYH2_k127_8896272_28 - - - - 0.0000000000000000004006 91.0
PYH2_k127_8896272_29 - - - - 0.0000000000000044 82.0
PYH2_k127_8896272_3 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007411 537.0
PYH2_k127_8896272_30 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000117 75.0
PYH2_k127_8896272_31 - - - - 0.0003748 51.0
PYH2_k127_8896272_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 442.0
PYH2_k127_8896272_5 FtsX-like permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 430.0
PYH2_k127_8896272_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 424.0
PYH2_k127_8896272_7 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 356.0
PYH2_k127_8896272_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 355.0
PYH2_k127_8896272_9 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005533 347.0
PYH2_k127_8907081_0 Highly conserved protein containing a thioredoxin domain K06888 - - 2.26e-248 784.0
PYH2_k127_8907081_1 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 2.067e-203 668.0
PYH2_k127_8907081_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006473 421.0
PYH2_k127_8907081_3 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 340.0
PYH2_k127_8907081_4 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000884 292.0
PYH2_k127_8907081_5 Staphylococcal nuclease homologues - - - 0.000000000000000000000000000000000000000000000001865 183.0
PYH2_k127_8907081_6 CHASE K02488,K21009 - 2.7.7.65 0.000000000000000000000000000000000000000000009936 175.0
PYH2_k127_8907081_7 Sh3 type 3 domain protein - - - 0.000000000000000000000000000000000000000001342 161.0
PYH2_k127_8907081_8 Protein of unknown function - - - 0.0000000000000000000000000000000000000001071 159.0
PYH2_k127_8929098_0 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 1.947e-205 647.0
PYH2_k127_8929098_1 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 411.0
PYH2_k127_8929098_10 - - - - 0.000000000000000000000000000000000000000005705 161.0
PYH2_k127_8929098_11 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000119 129.0
PYH2_k127_8929098_12 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000005242 99.0
PYH2_k127_8929098_13 AhpC/TSA family K03386 - 1.11.1.15 0.000000000000000008595 85.0
PYH2_k127_8929098_14 Belongs to the rubredoxin family - - - 0.000000004872 65.0
PYH2_k127_8929098_2 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 366.0
PYH2_k127_8929098_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 294.0
PYH2_k127_8929098_5 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000291 244.0
PYH2_k127_8929098_6 ABC-type multidrug transport system ATPase K01990,K11050 - - 0.000000000000000000000000000000000000000000000000000000002274 204.0
PYH2_k127_8929098_7 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000004904 202.0
PYH2_k127_8929098_8 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000001717 194.0
PYH2_k127_8929098_9 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000000000000000000000000000000005722 183.0
PYH2_k127_8954809_0 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 293.0
PYH2_k127_8954809_1 Phosphate sensor histidine kinase, HAMP and PAS domain-containing K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000004392 235.0
PYH2_k127_8954809_2 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000001083 188.0
PYH2_k127_8954809_3 PFAM CBS domain K07182 - - 0.0000000000000000000001034 106.0
PYH2_k127_9009801_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.299e-271 850.0
PYH2_k127_9009801_1 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000004254 197.0
PYH2_k127_9054014_0 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331 - 1.12.1.3,1.6.5.3 9.101e-230 727.0
PYH2_k127_9054014_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 561.0
PYH2_k127_9054014_2 proteolysis K07059 - - 0.0000000000000000000000000000000000000000000000000000000000000000000231 240.0
PYH2_k127_9054014_3 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K18330 - 1.12.1.3 0.00000000000000000000000000000000000000000000001727 183.0
PYH2_k127_9054014_4 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000005166 170.0
PYH2_k127_9054014_5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000001315 56.0
PYH2_k127_918284_0 SMART Elongator protein 3 MiaB NifB - - - 3.495e-211 665.0
PYH2_k127_918284_1 Sulphur transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009472 426.0
PYH2_k127_918284_2 Protoporphyrinogen oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 372.0
PYH2_k127_918284_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000002432 237.0
PYH2_k127_918284_4 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000006963 103.0
PYH2_k127_918284_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000142 68.0
PYH2_k127_9214513_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.241e-253 799.0
PYH2_k127_9214513_1 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 296.0
PYH2_k127_9214513_2 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 0.000000000000006477 77.0
PYH2_k127_9214914_0 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 494.0
PYH2_k127_9214914_1 TGS domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 290.0
PYH2_k127_9214914_2 Belongs to the sirtuin family. Class K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003614 275.0
PYH2_k127_9214914_3 Protein of unknown function (DUF1810) - - - 0.000000000000000000000000000000000000000000000000006378 186.0
PYH2_k127_9214914_4 Spermidine synthase K00797 - 2.5.1.16 0.000000000000000000000000000000000000179 151.0
PYH2_k127_9214914_5 Cysteine-rich secretory protein family - - - 0.000000000000000000000000000000000001338 145.0
PYH2_k127_9214914_6 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000006967 109.0
PYH2_k127_9231214_0 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 590.0
PYH2_k127_9231214_1 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000001972 192.0
PYH2_k127_9231214_2 Tetratricopeptide repeat - - - 0.0000000000002371 77.0
PYH2_k127_9231214_3 Putative zinc-finger - - - 0.00000000003888 74.0
PYH2_k127_9257538_0 - K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 388.0
PYH2_k127_9257538_1 - - - - 0.0000000000001445 79.0
PYH2_k127_9257538_2 Protein of unknown function (DUF2845) - - - 0.0000000004379 68.0
PYH2_k127_9257538_3 Protein of unknown function (DUF1624) - - - 0.0005123 43.0
PYH2_k127_9287381_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.838e-267 835.0
PYH2_k127_9287381_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 2.945e-215 676.0
PYH2_k127_9287381_10 PFAM Cyclic nucleotide-binding - - - 0.000182 49.0
PYH2_k127_9287381_2 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 475.0
PYH2_k127_9287381_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 443.0
PYH2_k127_9287381_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 416.0
PYH2_k127_9287381_5 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000007206 228.0
PYH2_k127_9287381_6 PFAM Amino acid-binding ACT - - - 0.000000000000000000000000000000000000000000000000000000000199 205.0
PYH2_k127_9287381_7 membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000002448 207.0
PYH2_k127_9287381_8 PFAM GCN5-related N-acetyltransferase K03825 - - 0.000000000002827 75.0
PYH2_k127_9287381_9 - - - - 0.0000000001024 70.0
PYH2_k127_9288316_0 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 485.0
PYH2_k127_9288316_1 Biotin-protein ligase, N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 328.0
PYH2_k127_9288316_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 306.0
PYH2_k127_9288316_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008597 284.0
PYH2_k127_9288316_4 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000002947 266.0
PYH2_k127_9288316_5 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000003926 211.0
PYH2_k127_9305703_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 408.0
PYH2_k127_9305703_1 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 337.0
PYH2_k127_9305703_2 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003217 288.0
PYH2_k127_932832_0 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 345.0
PYH2_k127_932832_1 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 325.0
PYH2_k127_932832_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000000000003624 215.0
PYH2_k127_932832_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000000000002163 192.0
PYH2_k127_932832_4 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000000000000000000000000000000000000000000007828 180.0
PYH2_k127_971915_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 311.0
PYH2_k127_971915_1 - - - - 0.000000000000000000000000000000000000000000000000006641 187.0
PYH2_k127_971915_2 heat shock protein binding K05516,K05801 - - 0.00000000000000000389 97.0
PYH2_k127_971915_3 Helix-turn-helix domain - - - 0.000000000000000161 89.0
PYH2_k127_972470_0 Anthranilate synthase component I K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 436.0
PYH2_k127_972470_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 395.0
PYH2_k127_972470_2 transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000002514 229.0
PYH2_k127_972470_3 HlyD membrane-fusion protein of T1SS K03543 - - 0.00000000000000000000000000000000000000000000000001884 189.0
PYH2_k127_972470_4 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000009967 136.0
PYH2_k127_992840_0 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001228 291.0
PYH2_k127_992840_1 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007187 279.0
PYH2_k127_992840_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000007107 224.0
PYH2_k127_992840_3 Transcriptional regulator, MerR family - - - 0.0000000000000000000000000000000001654 137.0
PYH2_k127_992840_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000003131 105.0
PYH2_k127_992840_5 Diguanylate cyclase - - - 0.00000000000000007996 94.0