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Overview

ID MAG03196
Name PYH2_bin.48
Sample SMP0074
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Thermodesulfovibrionia
Order Thermodesulfovibrionales
Family UBA6898
Genus UBA6898
Species
Assembly information
Completeness (%) 76.54
Contamination (%) 3.96
GC content (%) 52.0
N50 (bp) 9,827
Genome size (bp) 2,252,407

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2183

Gene name Description KEGG GOs EC E-value Score Sequence
PYH2_k127_1034848_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182,K16239,K16874 - 4.1.1.61,4.1.1.98 1.548e-212 670.0
PYH2_k127_1034848_1 Na H antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009897 588.0
PYH2_k127_1034848_2 Transcriptional regulator, BadM Rrf2 family - - - 0.000000000000000000000000000000000000000000002625 168.0
PYH2_k127_1034848_3 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000001699 124.0
PYH2_k127_1034848_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000003546 116.0
PYH2_k127_1034848_5 dehydrogenase - - - 0.0008002 42.0
PYH2_k127_1042126_0 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 2.236e-227 720.0
PYH2_k127_1042126_1 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00123,K00336,K05299,K06441 - 1.12.7.2,1.17.1.10,1.17.1.9,1.6.5.3 7.179e-212 678.0
PYH2_k127_1042126_2 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000163 189.0
PYH2_k127_1042126_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - 0.000000000000000000000000000000000000000000000000004064 189.0
PYH2_k127_1042126_4 Tetratricopeptide repeat - - - 0.0003948 51.0
PYH2_k127_1058275_0 Glycogen debranching enzyme - - - 0.0 1379.0
PYH2_k127_1058275_1 Domain of unknown function (DUF4143) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006588 277.0
PYH2_k127_1058275_2 - - - - 0.00000000000000000000000000216 117.0
PYH2_k127_1060959_0 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.764e-255 793.0
PYH2_k127_1060959_1 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 579.0
PYH2_k127_1060959_2 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 439.0
PYH2_k127_1060959_3 Aconitase C-terminal domain K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000002467 162.0
PYH2_k127_1060959_4 to PID 1054866 PID 2271024 K07491 - - 0.00000000000007322 73.0
PYH2_k127_1060959_5 Aconitase C-terminal domain K01681 - 4.2.1.3 0.000001286 50.0
PYH2_k127_1071984_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 493.0
PYH2_k127_1071984_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 365.0
PYH2_k127_1071984_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 355.0
PYH2_k127_1071984_3 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000114 193.0
PYH2_k127_1071984_4 B12 binding domain - - - 0.000000000000000006517 87.0
PYH2_k127_1071984_5 signal transduction protein with EFhand domain - - - 0.000007146 49.0
PYH2_k127_1081369_0 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 314.0
PYH2_k127_1081369_1 Pfam:Arch_ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 287.0
PYH2_k127_1081369_2 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000317 160.0
PYH2_k127_1081369_3 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000001444 134.0
PYH2_k127_1081369_4 PFAM CheW domain protein K03408 - - 0.00000000000000002076 91.0
PYH2_k127_1092119_0 - - - - 0.000000000000000000000000000000000000000000000000000000000001593 214.0
PYH2_k127_1092119_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000007502 222.0
PYH2_k127_1092119_2 nuclease K00590,K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 2.1.1.113,3.1.31.1 0.000000000000000000000000000000000000000000006332 169.0
PYH2_k127_1095536_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1097.0
PYH2_k127_1095536_1 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000003279 170.0
PYH2_k127_1095536_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000446 154.0
PYH2_k127_1095536_3 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000055 122.0
PYH2_k127_1095536_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000001102 80.0
PYH2_k127_11124_0 UDP binding domain K02474,K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 452.0
PYH2_k127_11124_1 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000000004244 149.0
PYH2_k127_11124_2 Nucleotidyltransferase domain - - - 0.0000000000000000000000001101 111.0
PYH2_k127_11124_3 PFAM VanZ like family - - - 0.000004146 59.0
PYH2_k127_1113559_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 306.0
PYH2_k127_1113559_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001831 277.0
PYH2_k127_1113559_2 NAD(P)H dehydrogenase K00355 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000716 222.0
PYH2_k127_1113559_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000001347 128.0
PYH2_k127_112695_0 nitric oxide dioxygenase activity K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 472.0
PYH2_k127_112695_1 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000000000000000000000000000002424 186.0
PYH2_k127_112695_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000002368 178.0
PYH2_k127_112695_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000004828 136.0
PYH2_k127_112695_4 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000000000009863 131.0
PYH2_k127_112695_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000001449 50.0
PYH2_k127_1128069_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 5.95e-236 741.0
PYH2_k127_1128069_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 461.0
PYH2_k127_1128069_10 Transcriptional regulator - - - 0.00000000000000000000000000000000000005888 147.0
PYH2_k127_1128069_11 Sulfurtransferase TusA - - - 0.000000000000000000000003115 104.0
PYH2_k127_1128069_12 - - - - 0.000002064 51.0
PYH2_k127_1128069_2 Aminotransferase class-V K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 417.0
PYH2_k127_1128069_3 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 380.0
PYH2_k127_1128069_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000003227 223.0
PYH2_k127_1128069_5 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000009299 222.0
PYH2_k127_1128069_6 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.0000000000000000000000000000000000000000000000000000009161 195.0
PYH2_k127_1128069_7 2 iron, 2 sulfur cluster binding K01465,K02823,K05784,K17828 - 1.3.1.14,3.5.2.3 0.00000000000000000000000000000000000000000000000000009401 195.0
PYH2_k127_1128069_8 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000000000002233 190.0
PYH2_k127_1128069_9 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.000000000000000000000000000000000000002881 154.0
PYH2_k127_1136929_0 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 1.946e-312 962.0
PYH2_k127_1136929_1 PFAM Glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 291.0
PYH2_k127_1229956_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 2.44e-272 850.0
PYH2_k127_1229956_1 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.00000000000000000000000000000000000000000000000000001743 196.0
PYH2_k127_1229956_2 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000001348 187.0
PYH2_k127_1229956_3 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000148 123.0
PYH2_k127_1229956_4 Large family of predicted nucleotide-binding domains - - - 0.0000000000000004259 78.0
PYH2_k127_1284598_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 415.0
PYH2_k127_1284598_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 404.0
PYH2_k127_1284598_2 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 370.0
PYH2_k127_1284598_3 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 349.0
PYH2_k127_1284598_4 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002417 271.0
PYH2_k127_1284598_5 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.0000000000000000000001148 98.0
PYH2_k127_1291998_0 ATPase BadF BadG BcrA BcrD type - - - 0.0 1202.0
PYH2_k127_1291998_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 5.222e-265 831.0
PYH2_k127_1291998_10 PFAM PSP1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002964 251.0
PYH2_k127_1291998_11 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000002324 224.0
PYH2_k127_1291998_12 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000007316 197.0
PYH2_k127_1291998_13 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000000000000000000003516 190.0
PYH2_k127_1291998_14 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000002127 164.0
PYH2_k127_1291998_15 cobalamin synthesis protein - - - 0.0000000000000000000000000000000000000001407 158.0
PYH2_k127_1291998_16 protein transport across the cell outer membrane K02246,K02457,K02459,K02672,K08084 - - 0.00000008488 60.0
PYH2_k127_1291998_17 Protein of unknown function (DUF1460) - - - 0.00001575 55.0
PYH2_k127_1291998_18 Prokaryotic N-terminal methylation motif K02459 - - 0.00002511 55.0
PYH2_k127_1291998_2 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 2.529e-228 724.0
PYH2_k127_1291998_3 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 391.0
PYH2_k127_1291998_4 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 364.0
PYH2_k127_1291998_5 von Willebrand factor (vWF) type A domain K02448 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 362.0
PYH2_k127_1291998_6 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 342.0
PYH2_k127_1291998_7 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 333.0
PYH2_k127_1291998_8 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 301.0
PYH2_k127_1291998_9 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004796 258.0
PYH2_k127_1351242_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000984 617.0
PYH2_k127_1351242_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009151 262.0
PYH2_k127_1351242_2 Protein of unknown function (DUF1698) - - - 0.0000000000000000000000000000000000000000000000000000000000000000205 235.0
PYH2_k127_1351242_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000002455 220.0
PYH2_k127_1351242_4 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000509 208.0
PYH2_k127_1351242_5 Methyltransferase domain - - - 0.0000000000004073 79.0
PYH2_k127_144665_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 5.458e-286 892.0
PYH2_k127_144665_1 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 389.0
PYH2_k127_144665_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005922 276.0
PYH2_k127_144665_3 MarR family transcriptional K15973 - - 0.000000000000000000000000000000000000000000004912 167.0
PYH2_k127_144665_4 LemA family K03744 - - 0.000000000001037 70.0
PYH2_k127_1498380_0 PFAM Metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 398.0
PYH2_k127_1498380_1 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 340.0
PYH2_k127_1498380_10 HicB family - - - 0.00000000001838 64.0
PYH2_k127_1498380_11 Protein of unknown function (DUF2934) - - - 0.000004376 52.0
PYH2_k127_1498380_12 Protein of unknown function (DUF2934) - - - 0.000007298 50.0
PYH2_k127_1498380_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000003666 232.0
PYH2_k127_1498380_3 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000003474 218.0
PYH2_k127_1498380_4 Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000000003256 168.0
PYH2_k127_1498380_5 Ankyrin repeat K06867 - - 0.00000000000000000000000000000000000000000006681 175.0
PYH2_k127_1498380_6 PFAM transposase, IS4 family protein - - - 0.0000000000000000000000000000007991 126.0
PYH2_k127_1498380_7 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000001487 109.0
PYH2_k127_1498380_8 HicB family - - - 0.00000000000000000002246 91.0
PYH2_k127_1498380_9 PFAM Integrase catalytic region - - - 0.00000000001004 67.0
PYH2_k127_1506784_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 316.0
PYH2_k127_1506784_1 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003206 236.0
PYH2_k127_1506784_2 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000623 144.0
PYH2_k127_1506784_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000000001312 96.0
PYH2_k127_1506784_4 Type II restriction enzyme, methylase subunits - - - 0.00004342 49.0
PYH2_k127_1544379_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 0.0 1200.0
PYH2_k127_1544379_1 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 459.0
PYH2_k127_1544379_10 EAL domain protein - - - 0.0000000001076 71.0
PYH2_k127_1544379_11 Ribosomal RNA adenine dimethylase - - - 0.00000001973 62.0
PYH2_k127_1544379_2 glucose sorbosone K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 402.0
PYH2_k127_1544379_3 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 356.0
PYH2_k127_1544379_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 332.0
PYH2_k127_1544379_5 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001262 274.0
PYH2_k127_1544379_6 PFAM Major Facilitator Superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000008202 241.0
PYH2_k127_1544379_7 Protein of unknown function (DUF1189) - - - 0.0000000000000000000000000007499 123.0
PYH2_k127_1544379_8 Polymer-forming cytoskeletal - - - 0.0000000000000002878 83.0
PYH2_k127_1544379_9 PFAM FAD dependent oxidoreductase K07137 - - 0.0000000000001318 71.0
PYH2_k127_1546683_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0 1075.0
PYH2_k127_1546683_1 Poly-beta-hydroxybutyrate polymerase K03821 - - 6.873e-253 791.0
PYH2_k127_1546683_2 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 425.0
PYH2_k127_1546683_3 2Fe-2S -binding domain K13483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007792 260.0
PYH2_k127_1546683_4 transposase activity - - - 0.000000000000000000000000000000000000004082 151.0
PYH2_k127_1546683_6 DDE superfamily endonuclease - - - 0.00005036 45.0
PYH2_k127_1546683_7 Winged helix-turn helix - - - 0.0005081 44.0
PYH2_k127_1565297_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 323.0
PYH2_k127_1565297_1 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000000000000000000007546 135.0
PYH2_k127_1565297_2 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000008047 100.0
PYH2_k127_1565297_3 DNA modification - - - 0.000000000000000000002318 98.0
PYH2_k127_1565297_4 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000002684 73.0
PYH2_k127_1565297_5 response regulator - - - 0.0000003744 57.0
PYH2_k127_1727764_0 His Kinase A (phosphoacceptor) domain - - - 6.207e-260 820.0
PYH2_k127_1727764_1 membrane transporter protein K07090 - - 1.592e-196 619.0
PYH2_k127_1727764_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000133 258.0
PYH2_k127_1727764_3 AMP binding - - - 0.00000000000000000000000000000000000000001407 158.0
PYH2_k127_1784415_0 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 566.0
PYH2_k127_1784415_1 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 304.0
PYH2_k127_1784415_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000005638 205.0
PYH2_k127_1784415_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000002407 207.0
PYH2_k127_1784415_4 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.0000000000000000000000000000000000000000000000000002417 193.0
PYH2_k127_1784415_5 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.0000000000000000003604 94.0
PYH2_k127_1784415_6 ATPase (AAA superfamily K07133 - - 0.0000000001333 68.0
PYH2_k127_180594_0 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02849 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 407.0
PYH2_k127_180594_1 Glycosyl transferase, family 2 K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 373.0
PYH2_k127_180594_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 315.0
PYH2_k127_180594_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000005939 236.0
PYH2_k127_180594_4 Glycosyl transferases group 1 - - - 0.00000000000007658 83.0
PYH2_k127_1825539_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 9.723e-283 880.0
PYH2_k127_1825539_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 347.0
PYH2_k127_1825539_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 305.0
PYH2_k127_1825539_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0001846 44.0
PYH2_k127_1863977_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 433.0
PYH2_k127_1863977_1 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 374.0
PYH2_k127_1863977_11 Diphthamide synthase - - - 0.00000000000000009228 80.0
PYH2_k127_1863977_12 - - - - 0.0000000000009776 70.0
PYH2_k127_1863977_13 PFAM aminotransferase class I and II K05825 - - 0.000000000003836 68.0
PYH2_k127_1863977_14 PFAM transposase IS200-family protein K07491 - - 0.0000000003967 63.0
PYH2_k127_1863977_15 - - - - 0.0000000004084 66.0
PYH2_k127_1863977_2 Protein of unknown function, DUF480 K09915 - - 0.0000000000000000000000000000000000000000000000000000000000001736 219.0
PYH2_k127_1863977_3 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000112 214.0
PYH2_k127_1863977_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000001212 198.0
PYH2_k127_1863977_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000001169 202.0
PYH2_k127_1863977_6 Glycine-zipper domain - - - 0.0000000000000000000000000000000000000000000331 167.0
PYH2_k127_1863977_7 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000007308 159.0
PYH2_k127_1863977_8 - - - - 0.000000000000000000002918 98.0
PYH2_k127_1863977_9 ATP-binding - - - 0.0000000000000000005062 92.0
PYH2_k127_1867262_0 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 460.0
PYH2_k127_1867262_1 PFAM type II secretion system K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 323.0
PYH2_k127_1867262_2 His Kinase A (phosphoacceptor) domain K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002443 288.0
PYH2_k127_1867262_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000009373 146.0
PYH2_k127_1872075_0 transferase activity, transferring glycosyl groups K02844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 318.0
PYH2_k127_1872075_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000003009 185.0
PYH2_k127_1872075_2 biosynthesis glycosyltransferase - - - 0.00000000000000000000000000004659 119.0
PYH2_k127_1872075_3 Glycosyltransferase like family 2 K07011,K20444 - - 0.00000000000000000000000006165 121.0
PYH2_k127_1872075_4 Glycosyl transferases group 1 - - - 0.00000006243 61.0
PYH2_k127_1872075_5 COG3307 Lipid A core - O-antigen ligase and related enzymes K02847 - - 0.0001182 54.0
PYH2_k127_1912439_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 417.0
PYH2_k127_1912439_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 388.0
PYH2_k127_1912439_2 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 386.0
PYH2_k127_1912439_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 327.0
PYH2_k127_1912439_4 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000579 236.0
PYH2_k127_1912439_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000003286 176.0
PYH2_k127_1912439_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000007044 160.0
PYH2_k127_1912439_7 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000001422 128.0
PYH2_k127_1912439_8 YtkA-like - - - 0.0000000000004695 74.0
PYH2_k127_1912439_9 PilZ domain - - - 0.00003306 53.0
PYH2_k127_1922327_0 - K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 374.0
PYH2_k127_1922327_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 311.0
PYH2_k127_1922327_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K14080 - 2.1.1.246,4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 301.0
PYH2_k127_1922327_3 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000001778 203.0
PYH2_k127_1922327_4 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000001894 180.0
PYH2_k127_1922327_5 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000000008187 135.0
PYH2_k127_1922327_6 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.00000000000000000000013 102.0
PYH2_k127_1922327_7 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000008104 87.0
PYH2_k127_1922327_8 Rdx family K07401 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009898,GO:0010941,GO:0016020,GO:0030334,GO:0030335,GO:0031224,GO:0031226,GO:0031235,GO:0031344,GO:0031346,GO:0032879,GO:0040012,GO:0040017,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0044087,GO:0044089,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051270,GO:0051272,GO:0051489,GO:0051491,GO:0060491,GO:0060548,GO:0065007,GO:0071944,GO:0098552,GO:0098562,GO:0120032,GO:0120034,GO:0120035,GO:2000145,GO:2000147 - 0.00000009573 56.0
PYH2_k127_1922327_9 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.000005492 49.0
PYH2_k127_1924134_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 1.382e-288 896.0
PYH2_k127_1924134_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 510.0
PYH2_k127_1947313_0 Mannose-6-phosphate isomerase, type K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 563.0
PYH2_k127_1947313_1 PFAM PHP domain protein K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000002201 166.0
PYH2_k127_1947313_2 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.000000000000000000000000000000001088 135.0
PYH2_k127_1947313_3 DNA-binding transcription factor activity K18996 - - 0.000000000000000000000000003389 115.0
PYH2_k127_2024583_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.252e-255 798.0
PYH2_k127_2024583_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 337.0
PYH2_k127_2024583_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 284.0
PYH2_k127_2035479_0 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 586.0
PYH2_k127_2035479_1 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000913 503.0
PYH2_k127_2035479_10 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000000002593 143.0
PYH2_k127_2035479_11 - - - - 0.000000000000000000000000004219 115.0
PYH2_k127_2035479_2 Receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 431.0
PYH2_k127_2035479_3 PFAM Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004214 357.0
PYH2_k127_2035479_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 322.0
PYH2_k127_2035479_5 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000002259 242.0
PYH2_k127_2035479_6 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000521 228.0
PYH2_k127_2035479_7 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000000001291 220.0
PYH2_k127_2035479_8 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000008417 208.0
PYH2_k127_2035479_9 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000001983 153.0
PYH2_k127_2065521_0 FAD binding domain K00394 - 1.8.99.2 0.0 1037.0
PYH2_k127_2065521_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1026.0
PYH2_k127_2065521_10 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000392 210.0
PYH2_k127_2065521_11 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000006449 205.0
PYH2_k127_2065521_12 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000009418 153.0
PYH2_k127_2065521_13 RDD family - - - 0.0000000000000000000000000005328 117.0
PYH2_k127_2065521_14 CBS domain - - - 0.000000000000000000000001318 108.0
PYH2_k127_2065521_16 SEC-C Motif Domain Protein - - - 0.000006735 53.0
PYH2_k127_2065521_17 lipopolysaccharide metabolic process K07126,K08309,K19804 - - 0.00009303 49.0
PYH2_k127_2065521_2 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 7.56e-322 999.0
PYH2_k127_2065521_3 Belongs to the sulfate adenylyltransferase family K00958,K13811 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 607.0
PYH2_k127_2065521_4 FAD dependent oxidoreductase K16885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 583.0
PYH2_k127_2065521_5 Actin K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 530.0
PYH2_k127_2065521_6 4Fe-4S dicluster domain K16887 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 387.0
PYH2_k127_2065521_7 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 336.0
PYH2_k127_2065521_8 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002745 263.0
PYH2_k127_2065521_9 Adenosine-5'-phosphosulfate reductase beta subunit K00395 - 1.8.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001322 252.0
PYH2_k127_2076513_0 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 461.0
PYH2_k127_2076513_1 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 363.0
PYH2_k127_2076513_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 323.0
PYH2_k127_2076513_3 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 332.0
PYH2_k127_2076513_4 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000006055 225.0
PYH2_k127_2076513_5 Membrane - - - 0.000000000003836 68.0
PYH2_k127_2097390_0 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 311.0
PYH2_k127_2098802_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 393.0
PYH2_k127_2098802_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000267 258.0
PYH2_k127_2098802_3 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000001273 233.0
PYH2_k127_2098802_4 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.0000000000000000000000000000000007035 143.0
PYH2_k127_2098802_5 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000682 87.0
PYH2_k127_2106115_0 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 487.0
PYH2_k127_2106115_1 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001429 284.0
PYH2_k127_2106115_2 cytochrome complex assembly - - - 0.0000000000000000000000000000000000000000000000000000000000000000001461 237.0
PYH2_k127_2106622_0 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008307 259.0
PYH2_k127_2106622_1 Histidine kinase - - - 0.0000000000000000000000000000000000000001103 169.0
PYH2_k127_2106622_2 HAMP domain - - - 0.000000000000000000000003366 118.0
PYH2_k127_2106622_3 - - - - 0.000000001757 61.0
PYH2_k127_21366_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1475.0
PYH2_k127_21366_1 ABC transporter K06158 - - 3.044e-203 645.0
PYH2_k127_21366_10 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005378 271.0
PYH2_k127_21366_11 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000007843 264.0
PYH2_k127_21366_12 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000006274 244.0
PYH2_k127_21366_13 4Fe-4S dicluster domain K03390,K16887 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000001829 227.0
PYH2_k127_21366_14 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000811 216.0
PYH2_k127_21366_15 Pfam:TPM K08988 - - 0.000000000000000000000000000000000000000000000000000001412 205.0
PYH2_k127_21366_17 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000001152 174.0
PYH2_k127_21366_18 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000006349 140.0
PYH2_k127_21366_19 AI-2E family transporter - - - 0.00000000000000000000000000000000003194 149.0
PYH2_k127_21366_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 490.0
PYH2_k127_21366_20 MlaD protein K02067 - - 0.000000000000000000000002086 113.0
PYH2_k127_21366_21 anti-sigma regulatory factor K04757 - 2.7.11.1 0.00000000000000000000006215 103.0
PYH2_k127_21366_22 Rhodanese Homology Domain - - - 0.00000000000000000007024 91.0
PYH2_k127_21366_23 STAS domain K04749 - - 0.0000000000000000003733 91.0
PYH2_k127_21366_24 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000005816 90.0
PYH2_k127_21366_3 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 395.0
PYH2_k127_21366_4 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 385.0
PYH2_k127_21366_5 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 331.0
PYH2_k127_21366_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006914 343.0
PYH2_k127_21366_7 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 316.0
PYH2_k127_21366_8 PFAM LemA family protein K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 294.0
PYH2_k127_21366_9 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001427 281.0
PYH2_k127_2176756_0 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 2.847e-252 790.0
PYH2_k127_2176756_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 2.715e-194 619.0
PYH2_k127_2176756_2 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 476.0
PYH2_k127_2176756_3 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000004809 184.0
PYH2_k127_2180091_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 1.834e-262 835.0
PYH2_k127_2180091_1 Protein of unknown function, DUF255 K06888 - - 1.492e-255 807.0
PYH2_k127_2180091_10 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 340.0
PYH2_k127_2180091_11 Type II and III secretion system protein K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 319.0
PYH2_k127_2180091_12 Cytochrome c3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000243 297.0
PYH2_k127_2180091_13 diguanylate cyclase K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 296.0
PYH2_k127_2180091_14 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002099 285.0
PYH2_k127_2180091_15 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000001211 233.0
PYH2_k127_2180091_16 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000008497 229.0
PYH2_k127_2180091_17 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000001514 200.0
PYH2_k127_2180091_18 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000001057 201.0
PYH2_k127_2180091_19 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000003349 192.0
PYH2_k127_2180091_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 2.683e-215 689.0
PYH2_k127_2180091_20 MarC family integral membrane protein - - - 0.000000000000000000000000000000000000000000002787 170.0
PYH2_k127_2180091_21 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000001843 161.0
PYH2_k127_2180091_22 Type II secretion system (T2SS), protein K K02460 - - 0.000000000000000000000000000000000000000006394 166.0
PYH2_k127_2180091_23 Sh3 type 3 domain protein - - - 0.000000000000000000000000000000000000003983 150.0
PYH2_k127_2180091_24 Phosphate transporter family K03306 - - 0.0000000000000000000000143 104.0
PYH2_k127_2180091_25 Phosphate transporter family K03306 - - 0.00000000134 61.0
PYH2_k127_2180091_26 Prokaryotic N-terminal methylation motif - - - 0.000000002333 66.0
PYH2_k127_2180091_27 phosphate transporter K03306 - - 0.00000001202 59.0
PYH2_k127_2180091_28 General secretion pathway protein H K02457 - - 0.00000001923 62.0
PYH2_k127_2180091_29 Phosphate transporter family K03306 - - 0.00000002203 57.0
PYH2_k127_2180091_3 type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 565.0
PYH2_k127_2180091_30 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000007921 57.0
PYH2_k127_2180091_31 fimbrial assembly K02461 - - 0.0000007902 62.0
PYH2_k127_2180091_32 Type II secretion system (T2SS), protein M subtype b - - - 0.000006434 55.0
PYH2_k127_2180091_33 Peptidase M56 - - - 0.00003509 55.0
PYH2_k127_2180091_34 Pfam:N_methyl_2 K02458 - - 0.0009028 47.0
PYH2_k127_2180091_4 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 555.0
PYH2_k127_2180091_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 535.0
PYH2_k127_2180091_6 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 454.0
PYH2_k127_2180091_7 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 409.0
PYH2_k127_2180091_8 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 396.0
PYH2_k127_2180091_9 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 364.0
PYH2_k127_2182765_0 Carbohydrate phosphorylase K00688,K00691 - 2.4.1.1,2.4.1.8 2.335e-293 924.0
PYH2_k127_2182765_1 thiosulfate sulfurtransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 320.0
PYH2_k127_2182765_2 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.00000000000000000000000000000000007299 136.0
PYH2_k127_2182765_3 PAS fold - - - 0.000000000000000000000000000004773 129.0
PYH2_k127_2182765_4 Sensor histidine kinase, Cache_1, HAMP and PAS domain-containing - - - 0.000000000000000005158 88.0
PYH2_k127_221377_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.063e-206 649.0
PYH2_k127_221377_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 294.0
PYH2_k127_221377_2 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K09181,K15520 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 0.000000000000000000000000000000000000000000000000002068 188.0
PYH2_k127_2293036_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 543.0
PYH2_k127_2293036_1 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 325.0
PYH2_k127_2293036_2 Tetratricopeptide repeat K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000001294 239.0
PYH2_k127_2293036_3 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000007451 192.0
PYH2_k127_2293036_4 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000007136 156.0
PYH2_k127_2301929_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1082.0
PYH2_k127_2301929_1 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 502.0
PYH2_k127_2301929_2 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 346.0
PYH2_k127_2301929_3 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 319.0
PYH2_k127_2301929_4 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
PYH2_k127_2301929_5 PFAM ABC transporter related K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009517 267.0
PYH2_k127_2301929_6 quinolinate catabolic process K00278,K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000002338 229.0
PYH2_k127_2301929_7 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000001244 190.0
PYH2_k127_2301929_8 response regulator - - - 0.0000000000000000000000000000000000000764 155.0
PYH2_k127_2301929_9 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000003275 124.0
PYH2_k127_2365530_0 PFAM cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 346.0
PYH2_k127_2365530_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 326.0
PYH2_k127_2365530_2 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004894 277.0
PYH2_k127_2365530_3 N-terminal domain of cytochrome oxidase-cbb3, FixP - - - 0.000000000000001048 81.0
PYH2_k127_2452553_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 1.165e-283 883.0
PYH2_k127_2452553_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000195 249.0
PYH2_k127_2452553_2 membrane - - - 0.00000000000000000000000000000000000009153 149.0
PYH2_k127_2553427_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.696e-282 877.0
PYH2_k127_2553427_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 480.0
PYH2_k127_2553427_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000005702 254.0
PYH2_k127_2553427_3 riboflavin synthase, alpha K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000009423 218.0
PYH2_k127_2553427_4 ROK family K00845 - 2.7.1.2 0.0000229 48.0
PYH2_k127_2557696_0 Protein export membrane protein K07003 - - 0.000000000000000000000000000000000000000000001944 185.0
PYH2_k127_2557696_1 Glycosyl transferase, family 2 K00786 - - 0.0000000000000000000000000000000000000000004253 166.0
PYH2_k127_2557696_2 - - - - 0.00000000000000000000000000000003541 128.0
PYH2_k127_2640003_0 Transport of potassium into the cell K03549 - - 3.613e-244 767.0
PYH2_k127_2640003_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 599.0
PYH2_k127_2640003_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000002802 234.0
PYH2_k127_2640003_3 - - - - 0.00000000000000000000000000000000000000006523 160.0
PYH2_k127_2640003_4 Domain of unknown function (DUF4912) K09942 - - 0.0000000000001641 83.0
PYH2_k127_2640003_5 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000004712 78.0
PYH2_k127_2646515_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 582.0
PYH2_k127_2646515_1 PFAM Patatin K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 416.0
PYH2_k127_2646515_3 PEGA domain - - - 0.000000003511 60.0
PYH2_k127_265282_0 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 525.0
PYH2_k127_265282_1 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 455.0
PYH2_k127_265282_10 Protein of unknown function DUF47 K02039,K07220 - - 0.0000000000000000000000000000000000000000000000000000003149 199.0
PYH2_k127_265282_11 Flavin reductase like domain - - - 0.0000000000000000000004442 96.0
PYH2_k127_265282_12 - - - - 0.0000000000000000002031 91.0
PYH2_k127_265282_13 Uncharacterized ACR, COG1993 - - - 0.00000000009717 64.0
PYH2_k127_265282_14 PFAM flavin reductase domain protein FMN-binding - - - 0.00000006228 54.0
PYH2_k127_265282_15 - - - - 0.000008697 50.0
PYH2_k127_265282_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 426.0
PYH2_k127_265282_3 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 426.0
PYH2_k127_265282_4 PFAM binding-protein-dependent transport systems inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 424.0
PYH2_k127_265282_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 419.0
PYH2_k127_265282_6 Signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 354.0
PYH2_k127_265282_7 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 294.0
PYH2_k127_265282_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009825 260.0
PYH2_k127_265282_9 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004149 255.0
PYH2_k127_273999_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.4e-224 704.0
PYH2_k127_273999_1 PFAM cobalamin (vitamin B12) biosynthesis CbiM K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 406.0
PYH2_k127_273999_10 DNA mismatch repair protein MutT K01515 - 3.6.1.13 0.00000000000000000001117 98.0
PYH2_k127_273999_11 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.00000000000000000002873 95.0
PYH2_k127_273999_12 Cupin domain - - - 0.0000000000003999 70.0
PYH2_k127_273999_13 MgtC family K07507 - - 0.00000000006575 68.0
PYH2_k127_273999_14 Phosphofructokinase K21071 - 2.7.1.11,2.7.1.90 0.00001934 48.0
PYH2_k127_273999_15 Cupin domain - - - 0.00002074 47.0
PYH2_k127_273999_2 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 367.0
PYH2_k127_273999_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 323.0
PYH2_k127_273999_4 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002375 276.0
PYH2_k127_273999_5 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000001007 202.0
PYH2_k127_273999_6 - - - - 0.0000000000000000000000000000000000000000000000000000004163 198.0
PYH2_k127_273999_7 CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000000001662 128.0
PYH2_k127_273999_8 - - - - 0.00000000000000000000000002389 113.0
PYH2_k127_273999_9 - - - - 0.0000000000000000000000001038 108.0
PYH2_k127_2783453_0 endonuclease III K07457 - - 0.0000000000000000000000000000000000000000000000000000000000000000002151 238.0
PYH2_k127_2783453_1 - - - - 0.0000000000000000000000000000000000000000000000000000002674 204.0
PYH2_k127_2783453_2 translation release factor activity - - - 0.00000000000000000000000000000000000000005841 155.0
PYH2_k127_2783453_3 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000006211 124.0
PYH2_k127_2783453_4 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000001875 118.0
PYH2_k127_2783453_5 DivIVA protein K04074 - - 0.00000000000000000000000001143 116.0
PYH2_k127_2797195_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 498.0
PYH2_k127_2797195_1 Domains REC, sigma54 interaction, HTH8 K02481 - - 0.00000000000000000000000000000000000000000000000000000000000002463 222.0
PYH2_k127_2797195_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000402 162.0
PYH2_k127_282415_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1484.0
PYH2_k127_282415_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003979 269.0
PYH2_k127_2873873_0 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 591.0
PYH2_k127_2873873_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 578.0
PYH2_k127_2873873_2 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 554.0
PYH2_k127_2873873_3 DNA polymerase III K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 523.0
PYH2_k127_2873873_4 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 473.0
PYH2_k127_2873873_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 452.0
PYH2_k127_2873873_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000008728 198.0
PYH2_k127_2873873_7 response regulator receiver - - - 0.000000000000000000000000000000000000000001498 162.0
PYH2_k127_2873873_8 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001374 126.0
PYH2_k127_2873873_9 - - - - 0.0000000002502 65.0
PYH2_k127_2892134_0 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 460.0
PYH2_k127_2892134_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 440.0
PYH2_k127_2892134_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 370.0
PYH2_k127_2892134_3 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 307.0
PYH2_k127_2892134_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000002209 222.0
PYH2_k127_2892134_5 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000004717 221.0
PYH2_k127_2892134_6 denitrification pathway - - - 0.00000000000000000000000000000000000001693 150.0
PYH2_k127_2892134_7 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000000000000000004995 130.0
PYH2_k127_2892134_8 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K07533 - 5.2.1.8 0.000000004104 68.0
PYH2_k127_302197_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.408e-202 636.0
PYH2_k127_302197_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 479.0
PYH2_k127_302197_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 408.0
PYH2_k127_302197_3 ACT domain - - - 0.00000000000000000000000000000000000000000000000000000001811 200.0
PYH2_k127_302197_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000002043 95.0
PYH2_k127_3060161_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 559.0
PYH2_k127_3060161_1 Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 518.0
PYH2_k127_3060161_10 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000001927 148.0
PYH2_k127_3060161_11 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000002653 91.0
PYH2_k127_3060161_12 - - - - 0.000000000000003525 77.0
PYH2_k127_3060161_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000002788 70.0
PYH2_k127_3060161_14 Belongs to the UPF0434 family K09791 - - 0.00000002403 55.0
PYH2_k127_3060161_2 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 449.0
PYH2_k127_3060161_3 response regulator K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 417.0
PYH2_k127_3060161_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 354.0
PYH2_k127_3060161_5 SEC-C motif K09858 - - 0.000000000000000000000000000000000000000000000000000000000003032 212.0
PYH2_k127_3060161_6 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000002099 218.0
PYH2_k127_3060161_7 His Kinase A (phosphoacceptor) domain K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000008069 208.0
PYH2_k127_3060161_8 - - - - 0.000000000000000000000000000000000000000000000000000001301 202.0
PYH2_k127_3060161_9 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000003998 181.0
PYH2_k127_3099208_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 571.0
PYH2_k127_3099208_1 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 366.0
PYH2_k127_3099208_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 322.0
PYH2_k127_3099208_3 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 314.0
PYH2_k127_3099208_4 Abc transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 287.0
PYH2_k127_3099208_5 PFAM ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001777 273.0
PYH2_k127_3099208_6 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.00000000000000000000000000000000000000000000000000001219 199.0
PYH2_k127_3099208_7 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000000000008528 120.0
PYH2_k127_3099208_8 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 0.000000000000000000000006236 111.0
PYH2_k127_3099208_9 Cyclic nucleotide-monophosphate binding domain K04739 - - 0.00000000000006913 83.0
PYH2_k127_3117002_0 Nitroreductase - - - 3.272e-205 651.0
PYH2_k127_3117002_1 AsmA-like C-terminal region K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000285 266.0
PYH2_k127_3117002_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000007311 198.0
PYH2_k127_3117002_3 PFAM Smr protein MutS2 - - - 0.000000000000000000000000000006972 121.0
PYH2_k127_3146741_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.476e-212 666.0
PYH2_k127_3146741_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 284.0
PYH2_k127_3146741_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352,K21307 - 1.8.5.5,1.8.5.6 0.00000000000000000000000000000000000000000000000000000000000000000000000005406 269.0
PYH2_k127_3146741_3 COG0437 Fe-S-cluster-containing hydrogenase components 1 - - - 0.00000000000000000000000000000001154 134.0
PYH2_k127_3146741_4 component of anaerobic dehydrogenases - - - 0.00000007749 61.0
PYH2_k127_3152133_0 3-isopropylmalate dehydrogenase activity K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 548.0
PYH2_k127_3152133_1 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 460.0
PYH2_k127_3152133_2 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005863 276.0
PYH2_k127_3157718_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 1.11e-291 914.0
PYH2_k127_3157718_1 leucyltransferase activity K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 294.0
PYH2_k127_3157718_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000003241 123.0
PYH2_k127_3157718_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.000000000002632 74.0
PYH2_k127_3157718_4 chlorophyll binding K03286,K03640 - - 0.000000005688 62.0
PYH2_k127_3158154_0 PFAM peptidase C14, caspase catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 390.0
PYH2_k127_3158154_1 PHP domain protein K03763 - 2.7.7.7 0.0000000001625 74.0
PYH2_k127_3158154_2 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05559 - - 0.0004185 47.0
PYH2_k127_3187545_0 GTP-binding GTPase Middle Region K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 617.0
PYH2_k127_3187545_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 525.0
PYH2_k127_3187545_2 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000001408 216.0
PYH2_k127_3221651_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.391e-261 821.0
PYH2_k127_3221651_1 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002106 280.0
PYH2_k127_3221651_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000002033 209.0
PYH2_k127_3221651_3 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000001422 140.0
PYH2_k127_3221651_4 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0003376 52.0
PYH2_k127_3249549_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 469.0
PYH2_k127_3249549_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 458.0
PYH2_k127_3249549_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 287.0
PYH2_k127_3249549_3 DHHA2 domain K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003076 286.0
PYH2_k127_3249549_4 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000009148 130.0
PYH2_k127_3249549_5 - - - - 0.00000000000000000000000005774 109.0
PYH2_k127_3249549_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000006286 102.0
PYH2_k127_3249549_7 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000004993 85.0
PYH2_k127_3249549_8 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000008017 68.0
PYH2_k127_3287022_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 9.571e-313 965.0
PYH2_k127_3287022_1 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 488.0
PYH2_k127_3287022_10 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000002309 173.0
PYH2_k127_3287022_11 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000001737 162.0
PYH2_k127_3287022_12 energy transducer activity K03832 - - 0.0000000000000000000000000000000000000001996 160.0
PYH2_k127_3287022_13 Universal stress protein family - - - 0.0000000000000000000000000000000000002648 146.0
PYH2_k127_3287022_14 proteolysis K03665 - - 0.00000000000000000000000000005203 122.0
PYH2_k127_3287022_15 Protein of unknown function DUF86 - - - 0.000002566 51.0
PYH2_k127_3287022_16 YMGG-like Gly-zipper - - - 0.0002362 49.0
PYH2_k127_3287022_2 Putative peptidoglycan binding domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 405.0
PYH2_k127_3287022_3 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 326.0
PYH2_k127_3287022_4 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 303.0
PYH2_k127_3287022_5 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000003961 264.0
PYH2_k127_3287022_6 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000006759 262.0
PYH2_k127_3287022_7 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000212 241.0
PYH2_k127_3287022_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000000000009934 193.0
PYH2_k127_3287022_9 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000001485 186.0
PYH2_k127_330915_0 L,D-transpeptidase catalytic domain K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 597.0
PYH2_k127_330915_1 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 541.0
PYH2_k127_330915_2 PFAM Major Facilitator Superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 531.0
PYH2_k127_330915_3 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 529.0
PYH2_k127_330915_4 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 377.0
PYH2_k127_330915_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 372.0
PYH2_k127_330915_6 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003326 278.0
PYH2_k127_330915_7 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000001385 156.0
PYH2_k127_330915_8 Exonuclease VII small subunit K03602 - 3.1.11.6 0.00000000000006698 75.0
PYH2_k127_330915_9 Alanine-zipper, major outer membrane lipoprotein - - - 0.00000000000415 70.0
PYH2_k127_333387_0 dUTP biosynthetic process K01494 GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006004 267.0
PYH2_k127_333387_1 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000000000000000001401 210.0
PYH2_k127_333387_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000001036 212.0
PYH2_k127_333387_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000708 178.0
PYH2_k127_333387_4 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.00000000000000000000000000001488 126.0
PYH2_k127_340957_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 5.738e-320 1003.0
PYH2_k127_340957_1 Sugar (and other) transporter K03446 - - 5.414e-233 730.0
PYH2_k127_340957_10 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.00000000000000000000000000000000001159 142.0
PYH2_k127_340957_11 Gram-negative-bacterium-type cell outer membrane assembly K04064,K06186 GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 - 0.0000000000000000000000001146 109.0
PYH2_k127_340957_12 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000001707 111.0
PYH2_k127_340957_13 - - - - 0.000000000000007783 78.0
PYH2_k127_340957_14 Modulates RecA activity K03565 - - 0.000000001817 64.0
PYH2_k127_340957_2 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 554.0
PYH2_k127_340957_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 503.0
PYH2_k127_340957_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005179 506.0
PYH2_k127_340957_5 HlyD membrane-fusion protein of T1SS K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 381.0
PYH2_k127_340957_6 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 373.0
PYH2_k127_340957_7 Anthranilate synthase component I K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 361.0
PYH2_k127_340957_8 transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000001594 220.0
PYH2_k127_340957_9 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000000000000000000000000000000000000000003419 222.0
PYH2_k127_3426962_0 COG3901 Regulator of nitric oxide reductase transcription K19339,K19343 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 482.0
PYH2_k127_3426962_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 342.0
PYH2_k127_3426962_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000001185 262.0
PYH2_k127_3426962_3 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000007545 196.0
PYH2_k127_3426962_4 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000000000000000000000000000001099 151.0
PYH2_k127_3426962_5 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000001418 151.0
PYH2_k127_3426962_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000008004 118.0
PYH2_k127_3426962_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000003004 89.0
PYH2_k127_3426962_8 Tol-Pal system TolA K03646 - - 0.00001046 56.0
PYH2_k127_3429028_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 335.0
PYH2_k127_3429028_1 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 302.0
PYH2_k127_3471442_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 3.393e-222 700.0
PYH2_k127_3471442_1 - - - - 0.0000000000000000000000000000000000000000000000000000002456 205.0
PYH2_k127_3471442_2 PFAM pyridoxamine 5-phosphate - - - 0.00000000000000000000000000000000000007309 145.0
PYH2_k127_3504322_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 602.0
PYH2_k127_3504322_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 518.0
PYH2_k127_3504322_2 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008669 422.0
PYH2_k127_3504322_3 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003481 276.0
PYH2_k127_3504322_4 Domain of unknown function (DUF4154) - - - 0.00000000000000000000000000000000000003892 150.0
PYH2_k127_3504322_5 translation initiation factor activity K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000001691 59.0
PYH2_k127_3590740_0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 286.0
PYH2_k127_3590740_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008312 278.0
PYH2_k127_3590740_2 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005458 264.0
PYH2_k127_3590740_3 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001488 271.0
PYH2_k127_3590740_4 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000001971 187.0
PYH2_k127_3590740_5 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000006804 180.0
PYH2_k127_3590740_6 PFAM PHP domain - - - 0.0000000000000000000000000000000000001818 149.0
PYH2_k127_3613334_0 Sigma-54 interaction domain K02481,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 436.0
PYH2_k127_3613334_1 GAF domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000001475 245.0
PYH2_k127_368741_0 PFAM aldo keto reductase K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 339.0
PYH2_k127_368741_1 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 333.0
PYH2_k127_368741_10 SpoVT / AbrB like domain - - - 0.00000000000001539 78.0
PYH2_k127_368741_11 PFAM Sodium Bile acid symporter family K03325 - - 0.0003798 44.0
PYH2_k127_368741_2 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002444 287.0
PYH2_k127_368741_3 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003939 255.0
PYH2_k127_368741_4 PFAM MgtC SapB transporter K07507 - - 0.000000000000000000000000000000000000000000000000000000000000001863 225.0
PYH2_k127_368741_5 low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000001911 165.0
PYH2_k127_368741_6 4Fe-4S binding domain - - - 0.000000000000000000000000000001192 123.0
PYH2_k127_368741_7 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000001655 125.0
PYH2_k127_368741_8 - - - - 0.0000000000000000000000008835 106.0
PYH2_k127_368741_9 COG0798 Arsenite efflux pump ACR3 and related K03325 - - 0.000000000000002503 78.0
PYH2_k127_3722800_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.854e-199 642.0
PYH2_k127_3722800_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 363.0
PYH2_k127_3746029_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 364.0
PYH2_k127_3746029_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006288 244.0
PYH2_k127_3746029_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005382 242.0
PYH2_k127_3746029_3 Transposase DDE domain K07487 - - 0.00000000000000000000001008 102.0
PYH2_k127_3746029_5 MacB-like periplasmic core domain - - - 0.000000000000000002013 90.0
PYH2_k127_3746029_6 - - - - 0.00000000004339 70.0
PYH2_k127_3776957_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 3.356e-227 721.0
PYH2_k127_3776957_1 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 433.0
PYH2_k127_3776957_10 Nitrate reductase gamma subunit K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00003266 55.0
PYH2_k127_3776957_2 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 362.0
PYH2_k127_3776957_3 PFAM Cysteine-rich domain K08264 - 1.8.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006483 333.0
PYH2_k127_3776957_4 Methionine synthase, cobalamin (vitamin B12)-binding module, cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 318.0
PYH2_k127_3776957_5 TIGRFAM iron-sulfur cluster binding protein - - - 0.0000000000000000000000000000000000000000000000009355 181.0
PYH2_k127_3776957_6 PFAM Carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000001985 155.0
PYH2_k127_3776957_7 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000002839 91.0
PYH2_k127_3776957_8 PFAM Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.0000000000000005189 87.0
PYH2_k127_3776957_9 - - - - 0.00000000000349 71.0
PYH2_k127_379378_0 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000001117 133.0
PYH2_k127_379378_1 geranylgeranyl reductase activity K14266 - 1.14.19.9 0.0000000000000000000000000000002584 128.0
PYH2_k127_379378_2 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000002959 117.0
PYH2_k127_379378_3 Zinc-binding dehydrogenase K00001 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0007275,GO:0007399,GO:0008150,GO:0009987,GO:0010975,GO:0016020,GO:0019867,GO:0022008,GO:0030154,GO:0031090,GO:0031344,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045664,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051239,GO:0051960,GO:0060284,GO:0065007,GO:0098588,GO:0098805,GO:0120035,GO:2000026 1.1.1.1 0.0000000004252 62.0
PYH2_k127_3827055_0 Domain of unknown function (DUF4139) - - - 2.595e-198 628.0
PYH2_k127_3827055_1 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 494.0
PYH2_k127_3827055_10 Evidence 5 No homology to any previously reported sequences K07156,K07245,K14166 - - 0.000000000000000000000000000000495 126.0
PYH2_k127_3827055_11 copper resistance K07245,K14166 - - 0.000000000000000000000000007916 126.0
PYH2_k127_3827055_12 Membrane - - - 0.00000000000000000000000005859 124.0
PYH2_k127_3827055_13 Putative zinc-finger - - - 0.000000000000001932 87.0
PYH2_k127_3827055_14 - - - - 0.000008518 54.0
PYH2_k127_3827055_15 - - - - 0.0003596 49.0
PYH2_k127_3827055_2 citrate synthase K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 400.0
PYH2_k127_3827055_3 PFAM Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 312.0
PYH2_k127_3827055_4 [acyl-carrier-protein] S-malonyltransferase activity K00645,K15327,K15329,K15355,K15469 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 308.0
PYH2_k127_3827055_5 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 294.0
PYH2_k127_3827055_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007361 282.0
PYH2_k127_3827055_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001291 282.0
PYH2_k127_3827055_8 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000775 210.0
PYH2_k127_383955_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.756e-294 919.0
PYH2_k127_383955_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000007645 139.0
PYH2_k127_383955_2 PFAM phosphoesterase RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.0000000000000001071 84.0
PYH2_k127_3851290_0 Surface antigen K07277 - - 1.189e-247 785.0
PYH2_k127_3851290_1 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 606.0
PYH2_k127_3851290_10 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000001927 117.0
PYH2_k127_3851290_11 GDP-mannose mannosyl hydrolase activity - - - 0.0000000000000000001178 91.0
PYH2_k127_3851290_2 Nitrite and sulphite reductase 4Fe-4S K11181 - 1.8.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 557.0
PYH2_k127_3851290_3 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 557.0
PYH2_k127_3851290_4 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 383.0
PYH2_k127_3851290_5 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 370.0
PYH2_k127_3851290_6 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 289.0
PYH2_k127_3851290_7 Psort location Cytoplasmic, score 8.96 K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003204 255.0
PYH2_k127_3851290_8 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000378 208.0
PYH2_k127_3851290_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.0000000000000000000000000000008954 128.0
PYH2_k127_3873095_0 CO dehydrogenase/acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 327.0
PYH2_k127_3873095_1 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 286.0
PYH2_k127_3873095_2 NosL - - - 0.00000000000000000000000000000001039 138.0
PYH2_k127_3873095_3 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.000000000000000000006109 94.0
PYH2_k127_3873095_4 long-chain fatty acid transport protein - - - 0.000000000000000000189 99.0
PYH2_k127_3900376_0 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 455.0
PYH2_k127_3900376_1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 302.0
PYH2_k127_3900376_2 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002084 235.0
PYH2_k127_3900376_3 adenylylsulfate kinase activity K00860 GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0055114,GO:0071704,GO:1901564 2.7.1.25 0.0000000000000000000000000000000000000000000000006849 178.0
PYH2_k127_3903535_0 Glycogen debranching enzyme - - - 0.0 1184.0
PYH2_k127_3903535_1 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 510.0
PYH2_k127_3909244_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1132.0
PYH2_k127_3909244_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.1e-322 1003.0
PYH2_k127_3909244_10 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000004102 210.0
PYH2_k127_3909244_11 phosphorelay signal transduction system - - - 0.0000000000000000000001574 103.0
PYH2_k127_3909244_12 Cysteine-rich small domain K07162 - - 0.000000000000000009525 85.0
PYH2_k127_3909244_13 - - - - 0.0000000000000006805 82.0
PYH2_k127_3909244_14 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000001048 81.0
PYH2_k127_3909244_15 Multidrug transporter - - - 0.00000000007124 66.0
PYH2_k127_3909244_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 587.0
PYH2_k127_3909244_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 488.0
PYH2_k127_3909244_4 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 454.0
PYH2_k127_3909244_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 389.0
PYH2_k127_3909244_6 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 351.0
PYH2_k127_3909244_7 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 325.0
PYH2_k127_3909244_8 Peptidase C26 K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 313.0
PYH2_k127_3909244_9 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006187 285.0
PYH2_k127_3929581_0 Nickel-dependent hydrogenase K00436 - 1.12.1.2 8.775e-244 760.0
PYH2_k127_3929581_1 NADH ubiquinone oxidoreductase K18006,K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 369.0
PYH2_k127_3929581_2 Coenzyme F420-reducing hydrogenase, gamma subunit K18007 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006547 319.0
PYH2_k127_3929581_3 NADH-quinone oxidoreductase subunit F K18005 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 306.0
PYH2_k127_3929581_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007802 242.0
PYH2_k127_3929581_5 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000557 156.0
PYH2_k127_3929581_6 hydrogenase maturation protease - - - 0.000000000000000000000000000000000000005375 150.0
PYH2_k127_394809_0 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 4.489e-320 990.0
PYH2_k127_394809_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 586.0
PYH2_k127_394809_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528,K16951 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 354.0
PYH2_k127_394809_3 CO-methylating acetyl-CoA synthase activity K00193,K14138 - 2.3.1.169 0.0000003248 52.0
PYH2_k127_3962593_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.055e-225 707.0
PYH2_k127_3962593_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 407.0
PYH2_k127_3962593_2 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 357.0
PYH2_k127_3962593_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000005224 241.0
PYH2_k127_3962593_4 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000005886 176.0
PYH2_k127_3962593_5 Chromate transport protein K07240 - - 0.000000000000000000000000000004265 127.0
PYH2_k127_3962593_6 Chromate transporter K07240 - - 0.00000000000000000000000001746 118.0
PYH2_k127_3962593_7 MatE K03327 - - 0.000000000000000000278 89.0
PYH2_k127_3962593_8 membrane K07058 - - 0.000000000009187 75.0
PYH2_k127_3962593_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000001296 66.0
PYH2_k127_3962810_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 411.0
PYH2_k127_3962810_1 Fumarate hydratase (Fumerase) K01676 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000595 275.0
PYH2_k127_3962810_2 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000004535 213.0
PYH2_k127_3962810_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000003545 153.0
PYH2_k127_3962810_4 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000006211 124.0
PYH2_k127_3962810_5 Rubrerythrin - - - 0.00000008862 60.0
PYH2_k127_3962810_6 Integrase core domain protein - - - 0.000355 46.0
PYH2_k127_3988435_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 608.0
PYH2_k127_4006824_0 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 2.844e-198 634.0
PYH2_k127_4006824_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 512.0
PYH2_k127_4006824_10 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000001229 121.0
PYH2_k127_4006824_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 453.0
PYH2_k127_4006824_3 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 454.0
PYH2_k127_4006824_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 346.0
PYH2_k127_4006824_5 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 328.0
PYH2_k127_4006824_6 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000005737 237.0
PYH2_k127_4006824_7 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000003644 241.0
PYH2_k127_4006824_8 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000001904 223.0
PYH2_k127_4006824_9 MraZ protein, putative antitoxin-like K03925 - - 0.00000000000000000000000000000000000000000000000008221 181.0
PYH2_k127_4021166_0 cell redox homeostasis - - - 2.863e-211 666.0
PYH2_k127_4021166_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 511.0
PYH2_k127_4021166_10 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000007927 125.0
PYH2_k127_4021166_2 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 403.0
PYH2_k127_4021166_3 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 351.0
PYH2_k127_4021166_4 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003229 317.0
PYH2_k127_4021166_5 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004665 282.0
PYH2_k127_4021166_6 Protein of unknown function (DUF3047) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001067 258.0
PYH2_k127_4021166_7 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000006763 257.0
PYH2_k127_4021166_8 peroxiredoxin activity K00627,K01607 - 2.3.1.12,4.1.1.44 0.0000000000000000000000000000000000004438 142.0
PYH2_k127_4021166_9 PFAM ribonuclease II K01147 - 3.1.13.1 0.00000000000000000000000000000000004182 138.0
PYH2_k127_4039311_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 402.0
PYH2_k127_4039311_1 radical SAM K06871 - - 0.000000000000000000000000000000000000000000000001388 185.0
PYH2_k127_4039311_2 YtkA-like - - - 0.000000000000000000000000000000002126 133.0
PYH2_k127_4039311_3 Glycosyl transferase family group 2 K07011 - - 0.00002569 47.0
PYH2_k127_4057509_0 Major facilitator - - - 9.375e-209 657.0
PYH2_k127_4057509_1 alpha amylase, catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 535.0
PYH2_k127_4057509_2 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 499.0
PYH2_k127_4057509_3 denitrification pathway K15876 GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 462.0
PYH2_k127_4057509_4 Sodium calcium exchanger membrane K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 388.0
PYH2_k127_4057509_5 Cysteine rich repeat - - - 0.000000000000000000000000000000000000000000000000818 178.0
PYH2_k127_4057509_6 Ion channel - - - 0.0000000000000000000000000000000000002348 149.0
PYH2_k127_4057509_7 Phospholipid methyltransferase - - - 0.00000000000000000006313 98.0
PYH2_k127_408238_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 317.0
PYH2_k127_408238_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 302.0
PYH2_k127_408238_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000004136 209.0
PYH2_k127_4120886_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 610.0
PYH2_k127_4120886_1 phenylalanine-tRNA ligase activity K01890 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 586.0
PYH2_k127_4120886_10 mercury ion transmembrane transporter activity K07213 - - 0.00000000000001971 76.0
PYH2_k127_4120886_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 467.0
PYH2_k127_4120886_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 316.0
PYH2_k127_4120886_4 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000001306 224.0
PYH2_k127_4120886_5 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000001448 188.0
PYH2_k127_4120886_6 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000216 141.0
PYH2_k127_4120886_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000001236 124.0
PYH2_k127_4120886_8 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000002882 89.0
PYH2_k127_4120886_9 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000192 75.0
PYH2_k127_4164903_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 561.0
PYH2_k127_4164903_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 523.0
PYH2_k127_4164903_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 414.0
PYH2_k127_4164903_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008314 322.0
PYH2_k127_4164903_4 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000001605 147.0
PYH2_k127_4164903_5 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000003232 145.0
PYH2_k127_4164903_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000114 147.0
PYH2_k127_4164903_7 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000001646 138.0
PYH2_k127_4164903_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000001046 130.0
PYH2_k127_4166055_0 ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 573.0
PYH2_k127_4166055_1 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 438.0
PYH2_k127_4166055_2 Belongs to the P(II) protein family K04751 - - 0.000000000001437 67.0
PYH2_k127_4170616_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 8.706e-267 842.0
PYH2_k127_4170616_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 4.037e-244 775.0
PYH2_k127_4170616_10 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000002366 239.0
PYH2_k127_4170616_11 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000253 143.0
PYH2_k127_4170616_12 Transcriptional regulator, MerR family - - - 0.0000000000000000000000000000000001134 138.0
PYH2_k127_4170616_13 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000001963 125.0
PYH2_k127_4170616_14 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000007326 90.0
PYH2_k127_4170616_15 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.0000000000001278 78.0
PYH2_k127_4170616_16 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.0000000001388 65.0
PYH2_k127_4170616_18 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000006763 68.0
PYH2_k127_4170616_19 PFAM SMP-30 Gluconolaconase - - - 0.0005539 47.0
PYH2_k127_4170616_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 6.337e-195 615.0
PYH2_k127_4170616_3 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 615.0
PYH2_k127_4170616_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 436.0
PYH2_k127_4170616_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 370.0
PYH2_k127_4170616_6 PFAM cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 317.0
PYH2_k127_4170616_7 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 321.0
PYH2_k127_4170616_8 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001625 297.0
PYH2_k127_4170616_9 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002021 284.0
PYH2_k127_4193042_0 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 512.0
PYH2_k127_4193042_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 372.0
PYH2_k127_4193042_2 CO dehydrogenase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 291.0
PYH2_k127_4193042_3 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000124 136.0
PYH2_k127_4193042_4 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000008568 131.0
PYH2_k127_4198879_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 2.378e-269 842.0
PYH2_k127_4198879_1 electron transfer activity K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 402.0
PYH2_k127_4198879_2 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 362.0
PYH2_k127_4244658_0 Fe-S oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 384.0
PYH2_k127_4244658_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000007102 260.0
PYH2_k127_4244658_2 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000000000002378 136.0
PYH2_k127_4244658_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0002769 49.0
PYH2_k127_4250232_0 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0 1129.0
PYH2_k127_4250232_1 hexose biosynthetic process K01810 - 5.3.1.9 2.831e-265 827.0
PYH2_k127_4250232_2 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005451 334.0
PYH2_k127_4250232_3 PFAM Transposase K07491 - - 0.0000000000000000000000000000000001432 135.0
PYH2_k127_4250232_4 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000001884 123.0
PYH2_k127_4250232_6 P-type ATPase K17686 - 3.6.3.54 0.00009747 47.0
PYH2_k127_4253783_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 417.0
PYH2_k127_4253783_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 358.0
PYH2_k127_4253783_10 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000002533 86.0
PYH2_k127_4253783_11 transferase activity, transferring glycosyl groups - - - 0.000001084 56.0
PYH2_k127_4253783_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000008045 251.0
PYH2_k127_4253783_3 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000009751 171.0
PYH2_k127_4253783_4 methyltransferase activity - - - 0.0000000000000000000000000000000000000000001728 165.0
PYH2_k127_4253783_5 Cytochrome P460 - - - 0.00000000000000000000000000000000000003849 149.0
PYH2_k127_4253783_6 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000000000000004356 118.0
PYH2_k127_4253783_7 Cold shock K03704 - - 0.0000000000000000000000000003005 114.0
PYH2_k127_4253783_8 Translation initiation factor SUI1 K03113 - - 0.0000000000000000000001147 101.0
PYH2_k127_4253783_9 - - - - 0.000000000000000000002359 95.0
PYH2_k127_4273592_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 524.0
PYH2_k127_4273592_1 phosphorelay signal transduction system K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009748 448.0
PYH2_k127_4273592_10 iron dependent repressor - - - 0.000000002332 61.0
PYH2_k127_4273592_11 Transposase - - - 0.00002083 47.0
PYH2_k127_4273592_12 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00005057 48.0
PYH2_k127_4273592_2 reverse transcriptase - - - 0.000000000000000000000000000000000000000000000009436 178.0
PYH2_k127_4273592_3 Histidine kinase - - - 0.00000000000000000000000000000000000009353 147.0
PYH2_k127_4273592_4 reverse transcriptase - - - 0.0000000000000000000000000000000001689 137.0
PYH2_k127_4273592_5 iron dependent repressor - - - 0.0000000000000000000000294 104.0
PYH2_k127_4273592_6 conserved protein (DUF2081) - - - 0.00000000000000000001928 94.0
PYH2_k127_4273592_7 reverse transcriptase - - - 0.00000000000000000008232 91.0
PYH2_k127_4273592_8 iron dependent repressor - - - 0.00000000000000001043 85.0
PYH2_k127_4273592_9 Transposase IS200 like - - - 0.0000000000002956 71.0
PYH2_k127_4310828_0 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335,K00355,K18331 - 1.12.1.3,1.6.5.2,1.6.5.3 2.315e-222 696.0
PYH2_k127_4310828_1 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 353.0
PYH2_k127_4310828_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000002127 71.0
PYH2_k127_4310828_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000004433 207.0
PYH2_k127_4310828_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000001737 198.0
PYH2_k127_4310828_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000001714 192.0
PYH2_k127_4310828_5 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K18330 - 1.12.1.3 0.0000000000000000000000000000000000000000000000001454 188.0
PYH2_k127_4310828_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000001805 144.0
PYH2_k127_4310828_7 Ferredoxin K17992 - 1.12.1.3 0.000000000000000000000000000000000001592 143.0
PYH2_k127_4310828_8 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000001204 131.0
PYH2_k127_4310828_9 phosphorelay signal transduction system K02437 - - 0.000000000000000000000000001705 123.0
PYH2_k127_432957_0 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 458.0
PYH2_k127_432957_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 405.0
PYH2_k127_432957_2 ATPase BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 395.0
PYH2_k127_432957_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 353.0
PYH2_k127_432957_4 B12 binding domain K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000839 194.0
PYH2_k127_432957_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000007341 190.0
PYH2_k127_432957_6 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.00000000000000000000000001443 112.0
PYH2_k127_432957_7 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000007246 70.0
PYH2_k127_432957_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - 0.0000000001636 69.0
PYH2_k127_4379943_0 Chromate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 458.0
PYH2_k127_4379943_1 SMART metal-dependent phosphohydrolase, HD region K06950 - - 0.000000000000000000000000000000000000000000000000000000000001239 228.0
PYH2_k127_4379943_2 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000006608 179.0
PYH2_k127_4379943_3 Universal stress protein family K07090 - - 0.000000000000000000000000000000000000003919 163.0
PYH2_k127_4401474_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 450.0
PYH2_k127_4401474_1 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000003321 213.0
PYH2_k127_4401474_2 - - - - 0.000000000000000000000000000000000000000000000000000000001321 214.0
PYH2_k127_4401474_3 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000008915 213.0
PYH2_k127_4401474_4 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. - - - 0.0000000000000004647 87.0
PYH2_k127_4401474_5 PFAM NHL repeat K21449 - - 0.0000000007834 72.0
PYH2_k127_4401474_6 Endonuclease/Exonuclease/phosphatase family - - - 0.00000005109 66.0
PYH2_k127_4435739_0 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 355.0
PYH2_k127_4435739_2 S1 domain K00243 - - 0.0000006295 55.0
PYH2_k127_4435739_3 - - - - 0.00001934 53.0
PYH2_k127_4464100_0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 375.0
PYH2_k127_4464100_1 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000000000000000000000000000000000000000002541 225.0
PYH2_k127_4573333_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 7.4e-316 981.0
PYH2_k127_4573333_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.123e-292 906.0
PYH2_k127_4573333_10 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000001965 256.0
PYH2_k127_4573333_11 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000007046 201.0
PYH2_k127_4573333_12 Tetratricopeptide repeat - - - 0.000000000000000000000000000001221 130.0
PYH2_k127_4573333_13 Protein of unknown function (DUF465) K09794 - - 0.000000000000000003317 86.0
PYH2_k127_4573333_14 Evidence 4 Homologs of previously reported genes of - - - 0.000000000005273 68.0
PYH2_k127_4573333_2 Dehydratase family K01687 - 4.2.1.9 6.349e-259 807.0
PYH2_k127_4573333_3 PFAM Radical SAM domain protein K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 592.0
PYH2_k127_4573333_4 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 466.0
PYH2_k127_4573333_5 Pyridoxal-phosphate dependent enzyme K01738,K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 443.0
PYH2_k127_4573333_6 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 416.0
PYH2_k127_4573333_7 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 377.0
PYH2_k127_4573333_8 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 318.0
PYH2_k127_4573333_9 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000142 273.0
PYH2_k127_4574304_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 3.26e-228 722.0
PYH2_k127_4574304_1 Aminotransferase class-III K01845 - 5.4.3.8 3.074e-204 642.0
PYH2_k127_4574304_2 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000002201 215.0
PYH2_k127_4574304_3 DDE superfamily endonuclease K07494 - - 0.0000000000000003587 82.0
PYH2_k127_4574304_4 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000002356 79.0
PYH2_k127_4602587_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 391.0
PYH2_k127_4602587_1 DNA polymerase Ligase (LigD) - - - 0.000000000000000000000000000000000000000000000000000000372 197.0
PYH2_k127_4602587_2 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.00000000000000000000000000000000000000009322 155.0
PYH2_k127_4602587_3 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.000000000000000000000000000009566 121.0
PYH2_k127_4602587_4 Transcription factor zinc-finger K09981 - - 0.00000000000000000000000000006383 118.0
PYH2_k127_4602587_5 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000001884 115.0
PYH2_k127_4602587_6 Integral membrane protein TerC family - - - 0.000000000000002389 79.0
PYH2_k127_4654851_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 501.0
PYH2_k127_4654851_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 303.0
PYH2_k127_4654851_2 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 305.0
PYH2_k127_4654851_3 3'-5' exonuclease activity K03547,K05970 - 3.1.1.53 0.0000000000000000000000000000000000000000000000000000000000000000001089 246.0
PYH2_k127_4654851_4 Protein of unknown function (DUF2867) - - - 0.000003635 50.0
PYH2_k127_4655874_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 610.0
PYH2_k127_4655874_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 381.0
PYH2_k127_4655874_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000007246 153.0
PYH2_k127_4655874_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000089 51.0
PYH2_k127_4667450_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1216.0
PYH2_k127_4667450_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 421.0
PYH2_k127_4667450_10 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000003383 137.0
PYH2_k127_4667450_11 4Fe-4S binding domain K00176 - 1.2.7.3 0.0000000000000000000001198 101.0
PYH2_k127_4667450_12 Universal stress protein family - - - 0.0000000000001385 81.0
PYH2_k127_4667450_14 membrane K09133 - - 0.0000000006801 60.0
PYH2_k127_4667450_15 SMART GGDEF domain containing protein - - - 0.00002278 48.0
PYH2_k127_4667450_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 370.0
PYH2_k127_4667450_3 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K01761 - 2.5.1.48,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 372.0
PYH2_k127_4667450_4 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002035 260.0
PYH2_k127_4667450_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000001417 224.0
PYH2_k127_4667450_6 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.000000000000000000000000000000000000000000000000000000037 202.0
PYH2_k127_4667450_7 HD domain - - - 0.000000000000000000000000000000000000000000000000000000119 211.0
PYH2_k127_4667450_8 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000002228 152.0
PYH2_k127_4667450_9 Belongs to the small heat shock protein (HSP20) family K06335,K13993 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564 - 0.00000000000000000000000000000000000009324 146.0
PYH2_k127_4679770_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 539.0
PYH2_k127_4679770_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 497.0
PYH2_k127_4679770_10 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000003997 70.0
PYH2_k127_4679770_11 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000002468 57.0
PYH2_k127_4679770_12 ACT domain protein - - - 0.0000421 53.0
PYH2_k127_4679770_2 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 479.0
PYH2_k127_4679770_3 cyclic nucleotide binding K01420,K10716,K10914 - - 0.0000000000000000000000000000000000000000003394 165.0
PYH2_k127_4679770_4 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000000003609 152.0
PYH2_k127_4679770_5 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000002141 149.0
PYH2_k127_4679770_6 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000006667 124.0
PYH2_k127_4679770_8 transposase activity - - - 0.000000000000000001373 93.0
PYH2_k127_4679770_9 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000001415 77.0
PYH2_k127_4681136_0 alcohol dehydrogenase K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 417.0
PYH2_k127_4681136_1 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000717 376.0
PYH2_k127_4681136_2 COG2931, RTX toxins and related Ca2 -binding proteins K20276 - - 0.000000000000000000000000000000000000000000000003478 197.0
PYH2_k127_4681136_3 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000006033 140.0
PYH2_k127_4681136_4 amine dehydrogenase activity - - - 0.0000000000000000000001767 114.0
PYH2_k127_4681136_5 - - - - 0.000000005694 61.0
PYH2_k127_4746080_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 601.0
PYH2_k127_4746080_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 512.0
PYH2_k127_4746080_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 469.0
PYH2_k127_4746080_3 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 346.0
PYH2_k127_4746080_4 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000007405 132.0
PYH2_k127_4767710_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 593.0
PYH2_k127_4767710_1 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 589.0
PYH2_k127_4767710_10 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000001543 233.0
PYH2_k127_4767710_11 cyclic diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000001243 233.0
PYH2_k127_4767710_12 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000001406 207.0
PYH2_k127_4767710_13 lyase activity - - - 0.00000000000000000000000000000000000000000000000000000001466 222.0
PYH2_k127_4767710_14 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000007895 190.0
PYH2_k127_4767710_15 required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.7.87 0.00000000000000000000000000000000000009485 152.0
PYH2_k127_4767710_16 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000001474 152.0
PYH2_k127_4767710_17 4Fe-4S binding domain - - - 0.0000000000000000000000000000000006729 142.0
PYH2_k127_4767710_18 RNA-binding protein - - - 0.000000000000000000000007396 104.0
PYH2_k127_4767710_2 Cytochrome C and Quinol oxidase polypeptide I K04561 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114 1.7.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 409.0
PYH2_k127_4767710_3 TIGRFAM cytochrome C family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 375.0
PYH2_k127_4767710_4 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 321.0
PYH2_k127_4767710_5 Cytochrome b5-like Heme/Steroid binding domain K07245,K14166 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005841 287.0
PYH2_k127_4767710_6 PFAM HPP family K07168 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002756 262.0
PYH2_k127_4767710_7 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005576 260.0
PYH2_k127_4767710_8 Protein of unknown function (DUF1460) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009379 243.0
PYH2_k127_4767710_9 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000009534 239.0
PYH2_k127_4816317_0 FtsX-like permease family K02004 - - 2.437e-316 986.0
PYH2_k127_4816317_1 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 421.0
PYH2_k127_4816317_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 350.0
PYH2_k127_4825857_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1099.0
PYH2_k127_4825857_1 peptidyl-lysine modification to peptidyl-hypusine - - - 0.0000000000000000000000000000000000000008306 153.0
PYH2_k127_4825857_2 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000001442 121.0
PYH2_k127_4825857_4 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000001324 72.0
PYH2_k127_4825857_5 Protein of unknown function (DUF1566) - - - 0.000002774 52.0
PYH2_k127_4890316_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 560.0
PYH2_k127_4890316_1 TIGRFAM Tat (twin-arginine translocation) pathway signal sequence K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 343.0
PYH2_k127_4890316_2 - - - - 0.0000000000000000000000000000000000000000000000001937 180.0
PYH2_k127_4890316_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000007383 90.0
PYH2_k127_4890316_4 DsrE/DsrF-like family K07235 - - 0.00000000002823 68.0
PYH2_k127_4890316_5 Belongs to the DsrF TusC family K07236 - - 0.00001179 52.0
PYH2_k127_4928344_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1201.0
PYH2_k127_4928344_1 Aminotransferase class I and II K14261 - - 2.106e-207 649.0
PYH2_k127_4928344_2 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 522.0
PYH2_k127_4928344_3 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 403.0
PYH2_k127_4928344_4 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 369.0
PYH2_k127_4928344_5 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 366.0
PYH2_k127_4928344_6 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.0000000000000000000000004455 109.0
PYH2_k127_4928344_7 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000002775 93.0
PYH2_k127_4928344_8 Tetratricopeptide repeat - - - 0.000000000007102 69.0
PYH2_k127_4928344_9 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0002356 43.0
PYH2_k127_501547_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 397.0
PYH2_k127_501547_1 bacterial OsmY and nodulation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008493 273.0
PYH2_k127_501547_10 ATP-independent chaperone mediated protein folding - - - 0.00004554 52.0
PYH2_k127_501547_11 bacterial OsmY and nodulation domain - - - 0.00006285 51.0
PYH2_k127_501547_2 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001385 263.0
PYH2_k127_501547_3 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000008744 276.0
PYH2_k127_501547_4 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000005416 210.0
PYH2_k127_501547_5 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000003978 189.0
PYH2_k127_501547_6 - - - - 0.000000000000000000000000000000002564 131.0
PYH2_k127_501547_7 - - - - 0.000000000000000000000000000006919 121.0
PYH2_k127_501547_8 Membrane - - - 0.000000000000000000000447 108.0
PYH2_k127_501547_9 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000005324 83.0
PYH2_k127_5021219_0 Telomere recombination K04656 - - 7.346e-234 747.0
PYH2_k127_5021219_1 Hydrogenase formation hypA family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 449.0
PYH2_k127_5021219_10 peptidyl-prolyl cis-trans isomerase activity K03769,K03771 - 5.2.1.8 0.000000000000001504 87.0
PYH2_k127_5021219_11 - - - - 0.0000000001063 68.0
PYH2_k127_5021219_13 Tetratricopeptide repeat - - - 0.00002288 53.0
PYH2_k127_5021219_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 411.0
PYH2_k127_5021219_3 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 374.0
PYH2_k127_5021219_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 315.0
PYH2_k127_5021219_5 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000799 308.0
PYH2_k127_5021219_6 nickel cation binding K04651,K19640 - - 0.00000000000000000000000000005242 120.0
PYH2_k127_5021219_7 Smr domain - - - 0.000000000000000000000000003398 120.0
PYH2_k127_5021219_8 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000005858 113.0
PYH2_k127_5021219_9 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000002377 97.0
PYH2_k127_503127_0 GTP-binding protein TypA K06207 - - 3.273e-270 843.0
PYH2_k127_503127_1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus K00341 - 1.6.5.3 9.491e-244 767.0
PYH2_k127_503127_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 614.0
PYH2_k127_503127_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 455.0
PYH2_k127_503127_4 sugar transferase K00996 - 2.7.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 417.0
PYH2_k127_503127_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000002445 195.0
PYH2_k127_503127_6 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.00000000002268 68.0
PYH2_k127_5036905_0 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 370.0
PYH2_k127_5036905_1 - - - - 0.0000000000000000000000000000000000000000000000000000000006345 206.0
PYH2_k127_5055481_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 576.0
PYH2_k127_5055481_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 585.0
PYH2_k127_5055481_10 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02236,K02278,K02506,K02654,K10966 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000004816 259.0
PYH2_k127_5055481_11 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000007622 256.0
PYH2_k127_5055481_12 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000001352 216.0
PYH2_k127_5055481_13 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000002307 224.0
PYH2_k127_5055481_14 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.0000000000000000000000000000000000000000000000000000000002599 210.0
PYH2_k127_5055481_15 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000005135 214.0
PYH2_k127_5055481_16 Diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.000000000000000000000000000000000000000000000000005357 189.0
PYH2_k127_5055481_17 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000004011 196.0
PYH2_k127_5055481_18 four-way junction helicase activity K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000007362 176.0
PYH2_k127_5055481_19 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000108 177.0
PYH2_k127_5055481_2 7TM receptor with intracellular HD hydrolase K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 496.0
PYH2_k127_5055481_20 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000168 171.0
PYH2_k127_5055481_21 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000004248 156.0
PYH2_k127_5055481_22 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000001154 138.0
PYH2_k127_5055481_23 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000007585 124.0
PYH2_k127_5055481_24 Protein of unknown function (DUF2905) - - - 0.0000000000000000001249 92.0
PYH2_k127_5055481_25 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000001096 92.0
PYH2_k127_5055481_26 Pectinesterase K01051 - 3.1.1.11 0.0000000000005748 80.0
PYH2_k127_5055481_28 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.0001582 52.0
PYH2_k127_5055481_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 471.0
PYH2_k127_5055481_4 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 425.0
PYH2_k127_5055481_5 ZIP Zinc transporter K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 409.0
PYH2_k127_5055481_6 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 387.0
PYH2_k127_5055481_7 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 347.0
PYH2_k127_5055481_8 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 329.0
PYH2_k127_5055481_9 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 298.0
PYH2_k127_5057614_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.108e-255 800.0
PYH2_k127_5057614_1 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 611.0
PYH2_k127_5057614_10 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002847 262.0
PYH2_k127_5057614_11 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008158 254.0
PYH2_k127_5057614_12 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006259 248.0
PYH2_k127_5057614_13 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000003791 211.0
PYH2_k127_5057614_14 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000001452 204.0
PYH2_k127_5057614_15 MlaC protein K07323 - - 0.00000000000000000000000000000000000000000000000000000001392 206.0
PYH2_k127_5057614_16 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000002874 202.0
PYH2_k127_5057614_17 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000479 185.0
PYH2_k127_5057614_18 Member of a two-component regulatory system K07644 - 2.7.13.3 0.000000000000000000000000000000007364 142.0
PYH2_k127_5057614_19 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.000000000000000000000000000004799 124.0
PYH2_k127_5057614_2 PFAM Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 547.0
PYH2_k127_5057614_20 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000003989 110.0
PYH2_k127_5057614_21 protein complex oligomerization - - - 0.00000000000000000000001521 108.0
PYH2_k127_5057614_22 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000001549 73.0
PYH2_k127_5057614_23 TIGRFAM cytochrome C family protein - - - 0.00007062 45.0
PYH2_k127_5057614_24 translation initiation factor activity K06996 - - 0.00007671 46.0
PYH2_k127_5057614_3 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 510.0
PYH2_k127_5057614_4 HlyD family secretion protein K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 507.0
PYH2_k127_5057614_5 PFAM 4Fe-4S K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 436.0
PYH2_k127_5057614_6 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 428.0
PYH2_k127_5057614_7 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 359.0
PYH2_k127_5057614_8 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 342.0
PYH2_k127_5057614_9 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 316.0
PYH2_k127_506893_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 581.0
PYH2_k127_506893_1 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 589.0
PYH2_k127_506893_10 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003584 284.0
PYH2_k127_506893_11 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009582 273.0
PYH2_k127_506893_12 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000006996 229.0
PYH2_k127_506893_13 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.000000000000000000000000000000000000000000000000000000374 201.0
PYH2_k127_506893_14 Domain of unknown function (DUF3842) - - - 0.0000000000000000000000000000000000000000000000000004606 188.0
PYH2_k127_506893_15 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.0000000000000000000000000000000000000000000002358 177.0
PYH2_k127_506893_16 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000004045 179.0
PYH2_k127_506893_17 PIN domain - - - 0.0000000000000000000000000000000001646 135.0
PYH2_k127_506893_18 SpoVT / AbrB like domain - - - 0.000000000004321 70.0
PYH2_k127_506893_2 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 572.0
PYH2_k127_506893_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 383.0
PYH2_k127_506893_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 353.0
PYH2_k127_506893_5 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 338.0
PYH2_k127_506893_6 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004941 328.0
PYH2_k127_506893_7 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 334.0
PYH2_k127_506893_8 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 302.0
PYH2_k127_506893_9 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 285.0
PYH2_k127_5110019_0 Heat shock 70 kDa protein K04043 - - 1.377e-318 985.0
PYH2_k127_5110019_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 417.0
PYH2_k127_5110019_2 spermidine synthase activity K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 406.0
PYH2_k127_5110019_3 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 329.0
PYH2_k127_5110019_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 301.0
PYH2_k127_5110019_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000554 177.0
PYH2_k127_5110019_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000005945 151.0
PYH2_k127_5110019_7 - - - - 0.0000000000000000007229 91.0
PYH2_k127_5116589_0 Histidine kinase - - - 8.66e-196 651.0
PYH2_k127_5116589_1 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 505.0
PYH2_k127_5116589_10 TIGRFAM rod shape-determining protein MreD K03571 - - 0.00005235 51.0
PYH2_k127_5116589_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 424.0
PYH2_k127_5116589_3 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 344.0
PYH2_k127_5116589_4 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 297.0
PYH2_k127_5116589_5 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001631 263.0
PYH2_k127_5116589_6 shape-determining protein MreC K03570 - - 0.0000000000000000000000000000000000000000000000001022 186.0
PYH2_k127_5116589_7 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000007544 139.0
PYH2_k127_5116589_8 - - - - 0.000000000000000000000002166 104.0
PYH2_k127_5116589_9 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000236 52.0
PYH2_k127_5120375_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 569.0
PYH2_k127_5120375_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 419.0
PYH2_k127_5120375_2 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 306.0
PYH2_k127_5120375_3 Tetratricopeptide repeat - - - 0.00000000000000000000002433 115.0
PYH2_k127_5169556_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 406.0
PYH2_k127_5169556_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 301.0
PYH2_k127_5169556_2 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001036 267.0
PYH2_k127_5169556_3 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000003559 220.0
PYH2_k127_5169556_4 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.000000000000000000000000000007774 123.0
PYH2_k127_5169556_5 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000621 56.0
PYH2_k127_5169716_0 Transposase IS116/IS110/IS902 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 322.0
PYH2_k127_5169716_1 - - - - 0.00000000000000000000000000000000000000000000000000000000001146 214.0
PYH2_k127_5169716_2 Archaea-specific editing domain of threonyl-tRNA synthetase - - - 0.0000000000000000000003349 96.0
PYH2_k127_5242003_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 464.0
PYH2_k127_5242003_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 421.0
PYH2_k127_5242003_2 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 322.0
PYH2_k127_5242003_3 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.0000000000000000000000000000000000002136 145.0
PYH2_k127_5242003_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000575 111.0
PYH2_k127_5247946_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 2.322e-299 939.0
PYH2_k127_5247946_1 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008227 287.0
PYH2_k127_5247946_2 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000004639 196.0
PYH2_k127_5247946_3 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000002146 121.0
PYH2_k127_5247946_4 spectrin binding K21440 - - 0.0000000000006164 82.0
PYH2_k127_5247946_5 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000000009053 58.0
PYH2_k127_5247946_6 DNA-binding transcription factor activity K03892 - - 0.0000007985 54.0
PYH2_k127_524858_0 Domain of unknown function (DUF1998) K02336,K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 2.7.7.7 2.105e-219 703.0
PYH2_k127_524858_1 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000007743 173.0
PYH2_k127_5252403_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.0 1387.0
PYH2_k127_5252403_1 PFAM phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 535.0
PYH2_k127_5252403_10 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001548 288.0
PYH2_k127_5252403_11 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000009026 248.0
PYH2_k127_5252403_12 deoxyhypusine monooxygenase activity K01387,K03301 - 3.4.24.3 0.000000000000000000000000000000000000000000000000000000000000001014 244.0
PYH2_k127_5252403_13 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000009001 235.0
PYH2_k127_5252403_14 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.00000000000000000000000000000000000000000000000000000004027 202.0
PYH2_k127_5252403_15 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000006779 221.0
PYH2_k127_5252403_16 protein with SCP PR1 domains - - - 0.00000000000000000000000000000000000000000000002986 177.0
PYH2_k127_5252403_17 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000003714 162.0
PYH2_k127_5252403_18 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000009225 156.0
PYH2_k127_5252403_19 SMART HNH nuclease K07451 - - 0.00000000000000000000000000000000000000005467 153.0
PYH2_k127_5252403_2 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005215 471.0
PYH2_k127_5252403_20 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000001649 131.0
PYH2_k127_5252403_21 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000003526 117.0
PYH2_k127_5252403_22 Protein of unknown function (DUF507) - - - 0.000000000000000000000000000443 117.0
PYH2_k127_5252403_23 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000003458 115.0
PYH2_k127_5252403_24 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000002427 104.0
PYH2_k127_5252403_25 Protein of unknown function (DUF507) - - - 0.00000000000000000000002089 102.0
PYH2_k127_5252403_26 protein-glutamate O-methyltransferase activity K00575,K03408,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000009492 93.0
PYH2_k127_5252403_27 cyclic nucleotide binding K10914 - - 0.000000000007652 66.0
PYH2_k127_5252403_28 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000002422 65.0
PYH2_k127_5252403_29 Putative regulatory protein - - - 0.0000000489 56.0
PYH2_k127_5252403_3 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 441.0
PYH2_k127_5252403_31 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0002646 46.0
PYH2_k127_5252403_4 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 390.0
PYH2_k127_5252403_5 Histidine kinase K07642,K18143 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 382.0
PYH2_k127_5252403_6 Beta-ketoacyl synthase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 370.0
PYH2_k127_5252403_7 Beta-ketoacyl synthase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 363.0
PYH2_k127_5252403_8 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 295.0
PYH2_k127_5252403_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004686 314.0
PYH2_k127_5288950_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000008656 270.0
PYH2_k127_5288950_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008962 247.0
PYH2_k127_5288950_3 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000002337 239.0
PYH2_k127_5288950_4 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000003597 226.0
PYH2_k127_5288950_5 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000005531 198.0
PYH2_k127_5288950_6 DUF167 K09131 - - 0.000000000000004019 79.0
PYH2_k127_5288950_7 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000007392 66.0
PYH2_k127_5288950_8 - - - - 0.00009981 49.0
PYH2_k127_5312352_0 Putative RNA methylase family UPF0020 K07444,K12297 - 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 441.0
PYH2_k127_5312352_1 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 326.0
PYH2_k127_5312352_2 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 289.0
PYH2_k127_5312352_3 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000003337 234.0
PYH2_k127_5312352_4 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000001014 230.0
PYH2_k127_5312352_5 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000003248 156.0
PYH2_k127_535293_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.346e-271 843.0
PYH2_k127_535293_1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 578.0
PYH2_k127_535293_10 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.0000000000000000000000000000000000002388 142.0
PYH2_k127_535293_11 DRTGG domain - - - 0.0000000000000000000000000000002258 126.0
PYH2_k127_535293_12 PFAM DRTGG domain - - - 0.000000000000000000000000001044 117.0
PYH2_k127_535293_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 379.0
PYH2_k127_535293_3 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 323.0
PYH2_k127_535293_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003191 289.0
PYH2_k127_535293_5 (Rhomboid) family K07059 - - 0.000000000000000000000000000000000000000000000000000000000000000000004694 241.0
PYH2_k127_535293_6 PHP-associated K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000004157 225.0
PYH2_k127_535293_7 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000003784 189.0
PYH2_k127_535293_8 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000001173 177.0
PYH2_k127_535293_9 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000002129 148.0
PYH2_k127_5429487_0 TonB-dependent Receptor Plug Domain K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 313.0
PYH2_k127_5429487_1 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000005863 206.0
PYH2_k127_5429487_2 protein methyltransferase activity K00595 - 2.1.1.132 0.00000000000000000000000000000000000000000000009322 176.0
PYH2_k127_5429487_3 - - - - 0.0000000000000000001914 89.0
PYH2_k127_5429487_4 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000001227 59.0
PYH2_k127_5439177_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007374 590.0
PYH2_k127_5439177_1 The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation K16899 - 3.6.4.12 0.000000006257 67.0
PYH2_k127_5441793_0 40-residue yvtn family beta-propeller repeat protein - - - 1.504e-211 665.0
PYH2_k127_5441793_1 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 391.0
PYH2_k127_5441793_2 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 304.0
PYH2_k127_5441793_3 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000002636 128.0
PYH2_k127_5527995_0 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000004661 149.0
PYH2_k127_5527995_1 Protein of unknown function DUF86 - - - 0.0000000000000000000000000007893 116.0
PYH2_k127_5527995_3 Nucleotidyltransferase domain K07075 - - 0.0000000000000000005994 89.0
PYH2_k127_5527995_4 TIGRFAM transcriptional regulator, AbrB family - - - 0.000000000000000003949 85.0
PYH2_k127_5527995_5 HNH endonuclease K07454 - - 0.00000000001564 65.0
PYH2_k127_5541777_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 372.0
PYH2_k127_5541777_1 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000000006292 220.0
PYH2_k127_5541777_2 Glutaredoxin - - - 0.000000000000005819 81.0
PYH2_k127_5541777_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000002359 68.0
PYH2_k127_5541777_4 Amidohydrolase family - - - 0.00000000003562 74.0
PYH2_k127_5541777_5 SEC-C motif - - - 0.00000009578 55.0
PYH2_k127_5541777_6 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000003622 52.0
PYH2_k127_5570364_0 Glycosyl hydrolase family 57 - - - 5.548e-232 739.0
PYH2_k127_5570364_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 600.0
PYH2_k127_5570364_10 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 296.0
PYH2_k127_5570364_11 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000001905 171.0
PYH2_k127_5570364_12 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000808 162.0
PYH2_k127_5570364_13 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000007014 115.0
PYH2_k127_5570364_14 - - - - 0.0000000000000000000000007304 119.0
PYH2_k127_5570364_15 - - - - 0.00000000000000009552 84.0
PYH2_k127_5570364_16 cell cycle K05589,K12065,K13052 - - 0.0000000000003154 74.0
PYH2_k127_5570364_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 549.0
PYH2_k127_5570364_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 473.0
PYH2_k127_5570364_4 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 462.0
PYH2_k127_5570364_5 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 464.0
PYH2_k127_5570364_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 413.0
PYH2_k127_5570364_7 TIGRFAM sulfate ABC transporter, permease protein CysW, sulfate ABC transporter, permease protein K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 383.0
PYH2_k127_5570364_8 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 340.0
PYH2_k127_5570364_9 COG0555 ABC-type sulfate transport system, permease component K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 308.0
PYH2_k127_5585996_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 606.0
PYH2_k127_5585996_1 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000003101 146.0
PYH2_k127_5585996_2 PDZ domain (Also known as DHR or GLGF) K04771 - 3.4.21.107 0.0000000000000000000000000000000002724 133.0
PYH2_k127_5585996_3 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000007291 110.0
PYH2_k127_5585996_4 Trypsin-like peptidase domain - - - 0.00000000000000000000000741 114.0
PYH2_k127_5585996_5 Trypsin K04771 - 3.4.21.107 0.000000000001224 72.0
PYH2_k127_5592068_0 COG0058 Glucan phosphorylase - - - 3.622e-203 640.0
PYH2_k127_5592068_1 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000004966 222.0
PYH2_k127_5592068_2 exodeoxyribonuclease I activity - - - 0.0000000001808 66.0
PYH2_k127_5602055_0 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 4.174e-299 936.0
PYH2_k127_5602055_1 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 336.0
PYH2_k127_5602055_2 PFAM aldo keto reductase K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004392 263.0
PYH2_k127_5602055_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000001065 183.0
PYH2_k127_5602055_4 - - - - 0.000000000000000000005996 99.0
PYH2_k127_5602055_5 cheY-homologous receiver domain - - - 0.00001151 55.0
PYH2_k127_5662208_0 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 433.0
PYH2_k127_5662208_1 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 377.0
PYH2_k127_5662208_2 alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000242 196.0
PYH2_k127_5662208_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000004785 136.0
PYH2_k127_5736043_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1718.0
PYH2_k127_5736043_1 galactose-1-phosphate uridylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 327.0
PYH2_k127_5736043_2 membrane K09790 - - 0.0000000000000000000003225 100.0
PYH2_k127_5790842_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.875e-260 820.0
PYH2_k127_5790842_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 2.124e-235 742.0
PYH2_k127_5790842_10 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000000001521 224.0
PYH2_k127_5790842_11 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000002372 152.0
PYH2_k127_5790842_12 Glu-tRNAGln amidotransferase C subunit K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000006363 112.0
PYH2_k127_5790842_13 hmm pf01609 - - - 0.000000000000000000000000105 109.0
PYH2_k127_5790842_14 nucleotidyltransferase activity K07075 - - 0.000000000000000000000004521 109.0
PYH2_k127_5790842_15 Protein of unknown function (DUF4197) - - - 0.000007925 53.0
PYH2_k127_5790842_2 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 521.0
PYH2_k127_5790842_3 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 516.0
PYH2_k127_5790842_4 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 492.0
PYH2_k127_5790842_5 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008968 447.0
PYH2_k127_5790842_6 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 381.0
PYH2_k127_5790842_7 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 309.0
PYH2_k127_5790842_8 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000002364 256.0
PYH2_k127_5790842_9 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000000000000001088 227.0
PYH2_k127_5814980_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 2.203e-202 636.0
PYH2_k127_5814980_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.744e-196 619.0
PYH2_k127_5814980_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000002168 243.0
PYH2_k127_5814980_3 PFAM MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000003677 220.0
PYH2_k127_5814980_4 TIGRFAM molybdenum cofactor synthesis domain - - - 0.000000000000000000000000000000000000000000000000000005437 196.0
PYH2_k127_5814980_5 - - - - 0.000000000000000000000000000000000000000000000000000006287 198.0
PYH2_k127_5814980_6 NmrA-like family - - - 0.000000000000000000000000000000000000001745 153.0
PYH2_k127_5814980_7 AMP binding - - - 0.00000000000000000000000000000000001786 140.0
PYH2_k127_5855952_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 305.0
PYH2_k127_5855952_1 DegT/DnrJ/EryC1/StrS aminotransferase family K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000001465 233.0
PYH2_k127_5855952_2 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000001028 107.0
PYH2_k127_5855952_3 Rhodanese Homology Domain - - - 0.000000002302 60.0
PYH2_k127_5869673_0 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 550.0
PYH2_k127_5869673_1 Protein of unknown function (DUF3604) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 361.0
PYH2_k127_5869673_2 Protein of unknown function K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008141 276.0
PYH2_k127_5869673_3 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000000125 187.0
PYH2_k127_5869673_4 Iron-sulfur cluster-binding domain K06871 - - 0.0000000000003057 72.0
PYH2_k127_5869673_5 RHS Repeat - - - 0.00003851 51.0
PYH2_k127_5869673_6 ATPase (AAA superfamily K07133 - - 0.0005067 45.0
PYH2_k127_5874915_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 3.595e-211 662.0
PYH2_k127_5874915_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 295.0
PYH2_k127_5874915_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000126 106.0
PYH2_k127_5885782_0 PFAM Isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001582 254.0
PYH2_k127_5885782_1 Uncharacterized ACR, COG1993 K06199,K09137 - - 0.000000000000000000000000000000000000000000000001687 177.0
PYH2_k127_5885782_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000004884 149.0
PYH2_k127_5885782_3 - - - - 0.00000000000000000000000000000003981 130.0
PYH2_k127_5919508_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1400.0
PYH2_k127_5919508_1 PD-(D/E)XK nuclease superfamily - - - 9.831e-219 716.0
PYH2_k127_5919508_2 Belongs to the helicase family. UvrD subfamily - - - 5.16e-203 664.0
PYH2_k127_5919508_3 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 435.0
PYH2_k127_5919508_4 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 350.0
PYH2_k127_5919508_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 343.0
PYH2_k127_5919508_6 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000219 98.0
PYH2_k127_5919508_7 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000004866 77.0
PYH2_k127_5919508_8 Cytochrome c554 and c-prime - - - 0.00000002488 61.0
PYH2_k127_5919508_9 Transposase (IS116 IS110 IS902 family) K07486 - - 0.00007729 48.0
PYH2_k127_5960746_0 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 469.0
PYH2_k127_5960746_1 Undecaprenyl-phosphate galactose phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 353.0
PYH2_k127_5960746_2 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001582 256.0
PYH2_k127_5960746_3 23S rRNA-intervening sequence protein - - - 0.0000000239 55.0
PYH2_k127_5978810_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 8.057e-200 631.0
PYH2_k127_5978810_1 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 436.0
PYH2_k127_5978810_2 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 396.0
PYH2_k127_5978810_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 363.0
PYH2_k127_5978810_4 SMART Cold shock protein K03704 - - 0.0000000000000000000000001047 107.0
PYH2_k127_5978810_5 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000006569 55.0
PYH2_k127_5986784_0 PFAM Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 560.0
PYH2_k127_5986784_1 Belongs to the bacterial solute-binding protein 3 family K09969 - - 0.00000000000000000000000000000000000000000000000000000000000002364 222.0
PYH2_k127_5986784_2 Cysteine rich repeat - - - 0.00000000000000000000000000000000000000001623 157.0
PYH2_k127_5986784_3 YMGG-like Gly-zipper - - - 0.0000000000000000000000000000000000000001334 156.0
PYH2_k127_5986784_4 - - - - 0.00000000000000000000000000001002 125.0
PYH2_k127_6019626_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006064 526.0
PYH2_k127_6019626_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000007 161.0
PYH2_k127_6019626_2 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000193 96.0
PYH2_k127_6019626_3 Protein conserved in bacteria - - - 0.0000002783 61.0
PYH2_k127_6019626_4 Ferritin-like domain K03594 - 1.16.3.1 0.000001416 52.0
PYH2_k127_6019626_5 Domain of unknown function (DUF4388) - - - 0.0003328 44.0
PYH2_k127_6023035_0 PFAM V-type ATPase 116 kDa K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 559.0
PYH2_k127_6023035_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 529.0
PYH2_k127_6023035_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000000000000000000158 114.0
PYH2_k127_6023035_12 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000008567 99.0
PYH2_k127_6023035_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000001864 104.0
PYH2_k127_6023035_14 Protein of unknown function (DUF2892) - - - 0.000000000008643 72.0
PYH2_k127_6023035_15 PFAM Disulphide bond isomerase, DsbC G-like K03981 - 5.3.4.1 0.00000000001187 74.0
PYH2_k127_6023035_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 497.0
PYH2_k127_6023035_3 PFAM MscS Mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 392.0
PYH2_k127_6023035_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 328.0
PYH2_k127_6023035_5 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 306.0
PYH2_k127_6023035_6 ATP synthase subunit D K02120 - - 0.000000000000000000000000000000000000000000000000000000000000001131 224.0
PYH2_k127_6023035_7 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000002809 228.0
PYH2_k127_6023035_8 - - - - 0.0000000000000000000000000000000000000000002247 164.0
PYH2_k127_6023035_9 Transposase DDE domain - - - 0.00000000000000000000000000000000000006091 146.0
PYH2_k127_608504_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1446.0
PYH2_k127_608504_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 494.0
PYH2_k127_6123566_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.019e-277 870.0
PYH2_k127_6123566_1 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000007877 184.0
PYH2_k127_6123566_2 SMART Cold shock protein K03704 - - 0.00000000000000000000007953 98.0
PYH2_k127_6123566_3 - - - - 0.00000000000000006102 83.0
PYH2_k127_6139904_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 592.0
PYH2_k127_6139904_1 Putative peptidoglycan binding domain K02450 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 529.0
PYH2_k127_6139904_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000002471 119.0
PYH2_k127_6139904_3 Type II secretion system protein B K02451 - - 0.0000000000000000000001434 107.0
PYH2_k127_6183739_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006908 233.0
PYH2_k127_6183739_1 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.0000000000000000000000000000000000000003258 152.0
PYH2_k127_6183739_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000595 150.0
PYH2_k127_6183739_3 peptidyl-tyrosine sulfation - - - 0.000001652 60.0
PYH2_k127_6198459_0 Elongation factor G, domain IV K02355 - - 6.901e-296 922.0
PYH2_k127_6198459_1 helicase superfamily c-terminal domain K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 519.0
PYH2_k127_6198459_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 355.0
PYH2_k127_6198459_3 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.00000000000000000000000000000000000000001716 155.0
PYH2_k127_6198459_4 Peptidase family M23 - - - 0.0000000000000000000000000000000000000004171 160.0
PYH2_k127_6198459_5 Membrane - - - 0.000000000000000000000007517 107.0
PYH2_k127_6198459_6 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.00000001588 63.0
PYH2_k127_619920_0 Belongs to the bacterial glucokinase family K00845 GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 444.0
PYH2_k127_619920_1 Sodium calcium exchanger membrane K07300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 383.0
PYH2_k127_619920_2 denitrification pathway K15876 GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 343.0
PYH2_k127_619920_3 Possible lysine decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001429 280.0
PYH2_k127_619920_4 Ion transport 2 domain protein - - - 0.000000000000000000000000000000000001278 147.0
PYH2_k127_6248103_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 8.477e-242 756.0
PYH2_k127_6248103_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.534e-227 721.0
PYH2_k127_6248103_10 - - - - 0.00000000000000000000004616 107.0
PYH2_k127_6248103_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.671e-226 710.0
PYH2_k127_6248103_3 TIGRFAM arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008127 519.0
PYH2_k127_6248103_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 475.0
PYH2_k127_6248103_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 324.0
PYH2_k127_6248103_6 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
PYH2_k127_6248103_7 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 292.0
PYH2_k127_6248103_8 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000002515 226.0
PYH2_k127_6248103_9 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000001421 115.0
PYH2_k127_6336551_0 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 331.0
PYH2_k127_6336551_1 MltA-interacting protein MipA K07274 - - 0.0000000000000000000000000000000000000000000000000000000004287 212.0
PYH2_k127_6336551_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000001653 203.0
PYH2_k127_6342658_0 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 515.0
PYH2_k127_6342658_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 414.0
PYH2_k127_6342658_10 Diadenylate cyclase - - - 0.00000000000000000000000000000000000000001323 164.0
PYH2_k127_6342658_11 glycosyl transferase family 2 K20444 - - 0.00000000000000000000162 104.0
PYH2_k127_6342658_12 serine threonine protein kinase K08884 - 2.7.11.1 0.00001266 56.0
PYH2_k127_6342658_2 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 349.0
PYH2_k127_6342658_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 328.0
PYH2_k127_6342658_4 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 306.0
PYH2_k127_6342658_5 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 287.0
PYH2_k127_6342658_6 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000005579 235.0
PYH2_k127_6342658_7 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000001915 226.0
PYH2_k127_6342658_8 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000004263 210.0
PYH2_k127_6342658_9 transferase activity, transferring glycosyl groups K00786 - - 0.000000000000000000000000000000000000000002273 169.0
PYH2_k127_6360952_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1225.0
PYH2_k127_6360952_1 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005217 264.0
PYH2_k127_6360952_2 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000001544 250.0
PYH2_k127_6426152_0 TRCF K03723 - - 6.869e-233 760.0
PYH2_k127_6426152_1 PAS domain K09155 - - 0.000000000000000000000000000000000000000000000001283 183.0
PYH2_k127_6426152_2 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000001408 101.0
PYH2_k127_6449782_0 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 1.081e-229 720.0
PYH2_k127_6449782_1 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000001125 209.0
PYH2_k127_6449782_2 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K09181,K15520 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 0.00000000000000000000000000000000000000000000000004599 183.0
PYH2_k127_6449782_3 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000003361 168.0
PYH2_k127_6449782_4 Predicted membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000003231 165.0
PYH2_k127_6449782_5 PFAM Patatin K07001 - - 0.0000000000000000000000000000000000000001681 151.0
PYH2_k127_6449782_6 AI-2E family transporter - - - 0.00000000000000000000000000000000001737 136.0
PYH2_k127_6456629_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 7.713e-312 979.0
PYH2_k127_6456629_1 Extracellular solute-binding protein, family 5 K02035 - - 5.284e-220 694.0
PYH2_k127_6456629_10 Prokaryotic N-terminal methylation motif K02650,K02655 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0000000008293 65.0
PYH2_k127_6456629_11 - - - - 0.00000003822 63.0
PYH2_k127_6456629_12 Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA) K16704 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576 2.3.1.210 0.00000004169 63.0
PYH2_k127_6456629_13 oligosaccharyl transferase activity - - - 0.000006235 58.0
PYH2_k127_6456629_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 520.0
PYH2_k127_6456629_3 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 430.0
PYH2_k127_6456629_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 416.0
PYH2_k127_6456629_5 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 411.0
PYH2_k127_6456629_6 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 404.0
PYH2_k127_6456629_7 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 324.0
PYH2_k127_6456629_8 PFAM Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002423 266.0
PYH2_k127_6456629_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000001905 257.0
PYH2_k127_6506184_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1639.0
PYH2_k127_6506184_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 427.0
PYH2_k127_6506184_2 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 388.0
PYH2_k127_6506184_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 385.0
PYH2_k127_6506184_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000001167 237.0
PYH2_k127_6506184_5 secretion protein K01993 - - 0.00000000000000000006874 101.0
PYH2_k127_6506184_6 transcriptional regulator - - - 0.00000000000000001619 90.0
PYH2_k127_6506184_7 Phage integrase family - - - 0.00000000000000003927 85.0
PYH2_k127_6537442_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008675 390.0
PYH2_k127_6537442_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352,K21307 - 1.8.5.5,1.8.5.6 0.0000000000000000000000000000000000000000000000000000000004792 215.0
PYH2_k127_6537442_2 - - - - 0.00000000007276 64.0
PYH2_k127_6545212_0 AMP-binding enzyme C-terminal domain K00666 - - 4.905e-257 802.0
PYH2_k127_6545212_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 606.0
PYH2_k127_6545212_2 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 569.0
PYH2_k127_6545212_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 545.0
PYH2_k127_6545212_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 494.0
PYH2_k127_6545212_5 CAAX prenyl protease N-terminal, five membrane helices - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 426.0
PYH2_k127_6545212_6 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 364.0
PYH2_k127_6545212_7 ABC-type polar amino acid transport system ATPase component K09972 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 304.0
PYH2_k127_6545212_8 Carboxymuconolactone decarboxylase family - - - 0.000000001171 64.0
PYH2_k127_6625572_0 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 581.0
PYH2_k127_6625572_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 325.0
PYH2_k127_6625572_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 317.0
PYH2_k127_6625572_3 Nitroreductase family - - - 0.00000000000008035 75.0
PYH2_k127_6654003_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.636e-249 779.0
PYH2_k127_6654003_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 538.0
PYH2_k127_6654003_2 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 522.0
PYH2_k127_6654003_3 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000002114 204.0
PYH2_k127_6654003_4 asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000005775 141.0
PYH2_k127_6657711_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 383.0
PYH2_k127_6657711_1 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000333 248.0
PYH2_k127_6657711_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000003788 198.0
PYH2_k127_6657711_3 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000006008 128.0
PYH2_k127_6657711_4 Archaea-specific editing domain of threonyl-tRNA synthetase - - - 0.000000000000000000000282 98.0
PYH2_k127_6657711_5 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000002804 93.0
PYH2_k127_6666921_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 624.0
PYH2_k127_6666921_1 Biogenesis protein K09792 - - 0.000000000000000000000000000000000000000000000001316 184.0
PYH2_k127_6666921_2 - - - - 0.00000000000000000000009482 102.0
PYH2_k127_6666921_3 FixH - - - 0.00000000000002883 79.0
PYH2_k127_6688451_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 7.394e-218 684.0
PYH2_k127_6688451_1 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 601.0
PYH2_k127_6688451_2 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 321.0
PYH2_k127_6688451_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004066 248.0
PYH2_k127_6688451_4 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.0000000000000000000000000000002862 142.0
PYH2_k127_6688451_5 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000264 60.0
PYH2_k127_6688451_6 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.000078 52.0
PYH2_k127_6688451_7 PBS lyase HEAT-like repeat - - - 0.0000792 51.0
PYH2_k127_6690257_0 PFAM PHP domain protein K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000000003309 192.0
PYH2_k127_6690257_1 O-Antigen ligase K02847 - - 0.000000000000000000000000000000000000000000000000002628 200.0
PYH2_k127_6690257_2 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000002534 184.0
PYH2_k127_6690257_3 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.0000000000000000000000000000000558 131.0
PYH2_k127_6690257_4 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000027 109.0
PYH2_k127_6690257_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000001889 67.0
PYH2_k127_6690257_6 Transposase K07491 - - 0.000003635 50.0
PYH2_k127_671341_0 cytochrome C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 398.0
PYH2_k127_671341_1 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 346.0
PYH2_k127_671341_2 - - - - 0.00000000000000000000000000000008897 143.0
PYH2_k127_671341_3 Protein of unknown function (DUF3300) - - - 0.0000000000004866 77.0
PYH2_k127_6716944_0 His Kinase A (phosphoacceptor) domain - - - 8e-225 719.0
PYH2_k127_6716944_1 membrane transporter protein K07090 - - 8.584e-194 612.0
PYH2_k127_6716944_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001978 249.0
PYH2_k127_6716944_11 AMP binding - - - 0.00000000000000000000000000000000000002561 147.0
PYH2_k127_6716944_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000005574 155.0
PYH2_k127_6716944_13 UTRA K03710 - - 0.000000000000000000000000000000001227 139.0
PYH2_k127_6716944_14 phosphorelay signal transduction system - - - 0.0000000000000000000000005112 106.0
PYH2_k127_6716944_2 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 569.0
PYH2_k127_6716944_3 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 519.0
PYH2_k127_6716944_4 protein secretion K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 544.0
PYH2_k127_6716944_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 470.0
PYH2_k127_6716944_6 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 452.0
PYH2_k127_6716944_7 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 420.0
PYH2_k127_6716944_8 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 295.0
PYH2_k127_6716944_9 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 288.0
PYH2_k127_6718941_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 535.0
PYH2_k127_6718941_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 319.0
PYH2_k127_6718941_2 Competence protein K02238 - - 0.00000000000000000000000292 114.0
PYH2_k127_6718941_3 YbbR-like protein - - - 0.0000000000003239 78.0
PYH2_k127_6718941_4 - - - - 0.0000000005452 62.0
PYH2_k127_6742895_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 344.0
PYH2_k127_6742895_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000021 288.0
PYH2_k127_6742895_2 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000003235 207.0
PYH2_k127_6761328_0 citrate synthase K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 401.0
PYH2_k127_6761328_1 PFAM Uncharacterised protein family UPF0182 K09118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 392.0
PYH2_k127_6761328_2 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 319.0
PYH2_k127_6761328_3 Winged helix-turn helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 307.0
PYH2_k127_6761328_4 Virulence factor BrkB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 287.0
PYH2_k127_6761328_5 Iron-storage protein K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000011 278.0
PYH2_k127_6761328_6 PilZ domain - - - 0.00000000000000000000000001986 118.0
PYH2_k127_6761328_7 endonuclease containing a URI domain K07461 - - 0.000000000002794 70.0
PYH2_k127_6761328_8 ankyrin repeat family protein - - - 0.00000000004447 69.0
PYH2_k127_6761328_9 - - - - 0.00000008084 56.0
PYH2_k127_6762303_0 Transcriptional regulator K11921,K19338 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 382.0
PYH2_k127_6762303_1 Domain of unknown function (DUF1957) K16149 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 370.0
PYH2_k127_6762303_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 354.0
PYH2_k127_6762303_3 C4-type zinc ribbon domain K07164 - - 0.000000000000000000000000000000000000002827 156.0
PYH2_k127_6764604_0 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 541.0
PYH2_k127_6764604_1 PFAM ResB family protein K07399 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 381.0
PYH2_k127_6764604_2 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 360.0
PYH2_k127_6764604_3 Histidine kinase HAMP - - - 0.0000000000000000000000000000000000000000000000000000000000001093 231.0
PYH2_k127_6764604_4 response regulator K02667 - - 0.00000000000002027 77.0
PYH2_k127_6764604_5 NAD dependent epimerase dehydratase family protein K01784 - 5.1.3.2 0.00000000001688 68.0
PYH2_k127_6794077_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000001454 154.0
PYH2_k127_6794077_1 Uncharacterized ACR, COG1678 - - - 0.00000000000000000000000000003124 126.0
PYH2_k127_6794077_2 Transposase IS200 like - - - 0.000003989 49.0
PYH2_k127_6833968_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 407.0
PYH2_k127_6833968_1 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 328.0
PYH2_k127_6833968_2 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000004804 222.0
PYH2_k127_6833968_3 CHASE K02488,K21009 - 2.7.7.65 0.000000000000000000000000000000000000000000108 174.0
PYH2_k127_6833968_4 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.0000000000000207 84.0
PYH2_k127_6833968_6 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000004941 56.0
PYH2_k127_6853656_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1270.0
PYH2_k127_6853656_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1050.0
PYH2_k127_6853656_2 phosphate acetyltransferase K00625,K13788 - 2.3.1.8 8.91e-279 872.0
PYH2_k127_6853656_3 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 2.828e-234 732.0
PYH2_k127_6853656_4 Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily K00850 - 2.7.1.11 3.026e-199 629.0
PYH2_k127_6853656_5 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002318 262.0
PYH2_k127_6853656_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000004314 167.0
PYH2_k127_6853656_7 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000000000000000001235 123.0
PYH2_k127_68814_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003981 579.0
PYH2_k127_68814_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 374.0
PYH2_k127_68814_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001061 202.0
PYH2_k127_68814_11 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000004545 176.0
PYH2_k127_68814_12 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000003245 168.0
PYH2_k127_68814_13 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000008003 158.0
PYH2_k127_68814_14 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000005112 152.0
PYH2_k127_68814_15 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000006946 141.0
PYH2_k127_68814_16 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000009088 135.0
PYH2_k127_68814_17 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000000001655 126.0
PYH2_k127_68814_18 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000001199 111.0
PYH2_k127_68814_19 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000005328 108.0
PYH2_k127_68814_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 330.0
PYH2_k127_68814_20 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000006275 104.0
PYH2_k127_68814_21 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000004844 79.0
PYH2_k127_68814_22 Ribosomal protein L30 K02907 - - 0.00000000000302 68.0
PYH2_k127_68814_3 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 284.0
PYH2_k127_68814_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 282.0
PYH2_k127_68814_5 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000002771 233.0
PYH2_k127_68814_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000004986 228.0
PYH2_k127_68814_7 Ribosomal protein L4/L1 family K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000004228 224.0
PYH2_k127_68814_8 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000001285 213.0
PYH2_k127_68814_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000823 203.0
PYH2_k127_6899363_0 GAF domain - - - 1.162e-207 697.0
PYH2_k127_6899363_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 533.0
PYH2_k127_6899363_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 434.0
PYH2_k127_6899363_3 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009965 288.0
PYH2_k127_6899363_4 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000349 252.0
PYH2_k127_6899363_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000001803 239.0
PYH2_k127_6899363_6 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000004708 166.0
PYH2_k127_6899363_7 Diguanylate cyclase - - - 0.0000000000000000000000000000000000005608 145.0
PYH2_k127_6911069_0 cyclopropane-fatty-acyl-phospholipid synthase K00574,K20238 - 2.1.1.317,2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 523.0
PYH2_k127_6911069_1 SOUL heme-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003045 253.0
PYH2_k127_6911069_2 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000002709 234.0
PYH2_k127_6913881_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 1.484e-198 623.0
PYH2_k127_6913881_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000914 507.0
PYH2_k127_6913881_10 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000001094 175.0
PYH2_k127_6913881_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000001176 177.0
PYH2_k127_6913881_12 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000001549 127.0
PYH2_k127_6913881_13 Belongs to the UPF0296 family K09777 - - 0.0000000000000000000000000000944 119.0
PYH2_k127_6913881_14 Tetratricopeptide repeat - - - 0.00000000000000000002011 103.0
PYH2_k127_6913881_15 Roadblock/LC7 domain - - - 0.000000000000000001358 90.0
PYH2_k127_6913881_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008412 374.0
PYH2_k127_6913881_3 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006953 325.0
PYH2_k127_6913881_4 Mur ligase family, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 320.0
PYH2_k127_6913881_5 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 306.0
PYH2_k127_6913881_6 Metallopeptidase family M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000007129 266.0
PYH2_k127_6913881_7 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000000002648 212.0
PYH2_k127_6913881_8 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000001459 213.0
PYH2_k127_6913881_9 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.000000000000000000000000000000000000000000000000000000009403 207.0
PYH2_k127_6945719_0 galactose-1-phosphate uridylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 335.0
PYH2_k127_6945719_1 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009952 278.0
PYH2_k127_6945719_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000005257 173.0
PYH2_k127_6945719_3 radical SAM domain protein - - - 0.0000000000000000000000000000000001213 144.0
PYH2_k127_6945719_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000002855 96.0
PYH2_k127_6959566_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 589.0
PYH2_k127_6959566_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 328.0
PYH2_k127_6959566_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000005339 160.0
PYH2_k127_6959566_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000005583 136.0
PYH2_k127_6959566_4 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000007206 89.0
PYH2_k127_6959566_5 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000004162 58.0
PYH2_k127_6959566_6 Protein of unknown function (DUF721) - - - 0.0001453 51.0
PYH2_k127_6960221_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.0 1922.0
PYH2_k127_6960221_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000002503 260.0
PYH2_k127_6960221_2 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000005723 214.0
PYH2_k127_6960221_3 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000004319 216.0
PYH2_k127_6964223_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.121e-235 737.0
PYH2_k127_6964223_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 5.855e-235 739.0
PYH2_k127_6964223_10 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 291.0
PYH2_k127_6964223_11 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 286.0
PYH2_k127_6964223_12 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001165 285.0
PYH2_k127_6964223_13 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004412 271.0
PYH2_k127_6964223_14 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001462 264.0
PYH2_k127_6964223_15 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000004725 235.0
PYH2_k127_6964223_17 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000008302 140.0
PYH2_k127_6964223_18 ThiS family K03636 - - 0.0000000000000000000000000000000008123 132.0
PYH2_k127_6964223_19 NIL - - - 0.00000000000000000000000000001298 119.0
PYH2_k127_6964223_2 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 2.17e-220 688.0
PYH2_k127_6964223_21 Cytochrome c K02305 - - 0.0000000005323 64.0
PYH2_k127_6964223_22 radical SAM domain protein - - - 0.000000303 57.0
PYH2_k127_6964223_23 Rubrerythrin - - - 0.00001881 53.0
PYH2_k127_6964223_3 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009072 599.0
PYH2_k127_6964223_4 Metalloenzyme superfamily K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 529.0
PYH2_k127_6964223_5 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 491.0
PYH2_k127_6964223_6 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 377.0
PYH2_k127_6964223_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 338.0
PYH2_k127_6964223_8 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008414 340.0
PYH2_k127_6964223_9 PFAM glycosyl transferase, family 9 K02841 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 320.0
PYH2_k127_6997376_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 546.0
PYH2_k127_6997376_1 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 435.0
PYH2_k127_6997376_2 S1 domain K00243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000121 282.0
PYH2_k127_6997376_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000143 233.0
PYH2_k127_6997376_4 - - - - 0.0000000000000000000000000000000000000000002916 168.0
PYH2_k127_6997376_5 - - - - 0.00041 49.0
PYH2_k127_7004434_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 444.0
PYH2_k127_7004434_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 436.0
PYH2_k127_7004434_10 Acetyltransferase (GNAT) family K03824 - - 0.0000009853 51.0
PYH2_k127_7004434_2 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 356.0
PYH2_k127_7004434_3 PLD-like domain K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002278 273.0
PYH2_k127_7004434_4 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000007629 222.0
PYH2_k127_7004434_5 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000002633 200.0
PYH2_k127_7004434_6 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.000000000000000000000000000000000000000000000000000005608 198.0
PYH2_k127_7004434_7 PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - 0.000000000000000000000000000000000007294 139.0
PYH2_k127_7004434_8 Protein of unknown function DUF134 - - - 0.000000000000000000000000188 110.0
PYH2_k127_7004434_9 - K06039,K07092 - - 0.0000001855 57.0
PYH2_k127_7020150_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 518.0
PYH2_k127_7020150_1 O-methyltransferase K00588 - 2.1.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000007446 265.0
PYH2_k127_7020150_2 - - - - 0.00000000000000000000000000000000000000000000000000000006166 207.0
PYH2_k127_7020150_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000003808 96.0
PYH2_k127_7036332_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 4.285e-228 715.0
PYH2_k127_7036332_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 1.529e-201 644.0
PYH2_k127_7036332_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000004919 226.0
PYH2_k127_7055114_0 all-trans-retinol 13,14-reductase activity K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 560.0
PYH2_k127_7055114_1 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 375.0
PYH2_k127_7055114_10 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000001038 88.0
PYH2_k127_7055114_11 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000003801 58.0
PYH2_k127_7055114_2 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 306.0
PYH2_k127_7055114_3 chlorophyll binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003364 259.0
PYH2_k127_7055114_4 SMART metal-dependent phosphohydrolase, HD region K06950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005714 241.0
PYH2_k127_7055114_5 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003711 227.0
PYH2_k127_7055114_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000001049 168.0
PYH2_k127_7055114_7 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000008191 158.0
PYH2_k127_7055114_8 protein histidine kinase activity K01768,K03406,K07636,K07716,K17763 - 2.7.13.3,4.6.1.1 0.0000000000000000000000000000000006296 138.0
PYH2_k127_7055114_9 PFAM Major Facilitator Superfamily - - - 0.000000000000000000002201 94.0
PYH2_k127_7099170_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 433.0
PYH2_k127_7114915_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 496.0
PYH2_k127_7114915_1 Large family of predicted nucleotide-binding domains K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 386.0
PYH2_k127_7114915_10 HD domain K07814 - - 0.00000008736 62.0
PYH2_k127_7114915_11 - - - - 0.0000006418 51.0
PYH2_k127_7114915_2 denitrification pathway K02569,K15876 - - 0.000000000000000000000000000000000000000000000000000000000005922 216.0
PYH2_k127_7114915_3 Putative zinc- or iron-chelating domain - - - 0.00000000000000000000000000000000000000000000000000000009192 206.0
PYH2_k127_7114915_4 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000003933 169.0
PYH2_k127_7114915_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000002098 172.0
PYH2_k127_7114915_6 methyltransferase - - - 0.000000000000000000000000000000000000009457 152.0
PYH2_k127_7114915_7 EamA-like transporter family - - - 0.00000000000000000000000000001574 121.0
PYH2_k127_7114915_8 4Fe-4S binding domain - - - 0.000000000000002859 78.0
PYH2_k127_7114915_9 Cupin 2, conserved barrel domain protein - - - 0.000000000006167 70.0
PYH2_k127_7119066_0 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 321.0
PYH2_k127_7119066_1 - - - - 0.0000000000000000000000000000000002428 139.0
PYH2_k127_7119066_2 cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000004522 98.0
PYH2_k127_7119066_3 PFAM UvrD REP helicase - - - 0.0000000000007626 74.0
PYH2_k127_7184687_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 458.0
PYH2_k127_7184687_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004918 275.0
PYH2_k127_7184687_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004003 250.0
PYH2_k127_7184687_3 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000007551 216.0
PYH2_k127_7184687_4 Domain of unknown function (DUF3786) - - - 0.0000000000000000000000000005418 118.0
PYH2_k127_7185145_0 PFAM S-adenosylmethionine synthetase (MAT) K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 543.0
PYH2_k127_7185145_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 520.0
PYH2_k127_7185145_10 Protein of unknown function (DUF2892) - - - 0.00000000000000000002236 92.0
PYH2_k127_7185145_11 lyase activity - - - 0.00000000000004822 76.0
PYH2_k127_7185145_13 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000004746 66.0
PYH2_k127_7185145_2 Metal-dependent phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002704 253.0
PYH2_k127_7185145_3 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000007857 224.0
PYH2_k127_7185145_4 Protein of unknown function DUF262 - - - 0.000000000000000000000000000000000000000001196 170.0
PYH2_k127_7185145_5 nucleotide phosphatase activity, acting on free nucleotides K00943,K02013,K02017,K03574,K03752,K06928 - 2.7.4.9,2.7.7.77,3.6.1.15,3.6.1.55,3.6.3.29,3.6.3.34 0.00000000000000000000000000000000000001926 150.0
PYH2_k127_7185145_6 Glutathione peroxidase - - - 0.000000000000000000000000000000000003301 144.0
PYH2_k127_7185145_7 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000001006 141.0
PYH2_k127_7185145_8 - - - - 0.0000000000000000000000000000597 121.0
PYH2_k127_7185145_9 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000001869 120.0
PYH2_k127_7212626_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1466.0
PYH2_k127_7212626_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1162.0
PYH2_k127_7212626_10 Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 366.0
PYH2_k127_7212626_11 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 374.0
PYH2_k127_7212626_12 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 361.0
PYH2_k127_7212626_13 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 358.0
PYH2_k127_7212626_14 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 361.0
PYH2_k127_7212626_15 Phage integrase, N-terminal SAM-like domain K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 335.0
PYH2_k127_7212626_16 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 320.0
PYH2_k127_7212626_17 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 287.0
PYH2_k127_7212626_18 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000009638 255.0
PYH2_k127_7212626_19 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005462 254.0
PYH2_k127_7212626_2 Domain in cystathionine beta-synthase and other proteins. K07182 - - 2.155e-242 764.0
PYH2_k127_7212626_20 Formylmethanofuran dehydrogenase, subunit e K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000002435 231.0
PYH2_k127_7212626_21 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000002093 228.0
PYH2_k127_7212626_22 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000004489 229.0
PYH2_k127_7212626_23 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000000005353 171.0
PYH2_k127_7212626_24 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000003476 155.0
PYH2_k127_7212626_25 GYD domain - - - 0.0000000000000000000000000000000001488 134.0
PYH2_k127_7212626_26 K( ) H( ) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels K11105 GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006884,GO:0008150,GO:0008324,GO:0008361,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0090066,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.00000000000000000000000000002806 121.0
PYH2_k127_7212626_27 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000000007282 109.0
PYH2_k127_7212626_28 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000003428 91.0
PYH2_k127_7212626_29 sulfur carrier activity K04085 - - 0.00000000000000001797 85.0
PYH2_k127_7212626_3 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 3.083e-201 634.0
PYH2_k127_7212626_4 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 554.0
PYH2_k127_7212626_5 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 576.0
PYH2_k127_7212626_6 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 546.0
PYH2_k127_7212626_7 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004764 542.0
PYH2_k127_7212626_8 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 489.0
PYH2_k127_7212626_9 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 450.0
PYH2_k127_722111_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 538.0
PYH2_k127_722111_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 311.0
PYH2_k127_722111_2 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 284.0
PYH2_k127_722111_3 PFAM PfkB K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000001321 254.0
PYH2_k127_722111_4 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000001247 124.0
PYH2_k127_722111_5 protein histidine kinase activity K01768,K03406,K07636,K07716,K17763 - 2.7.13.3,4.6.1.1 0.0000000000000000000000001763 117.0
PYH2_k127_722111_6 - - - - 0.00000002226 58.0
PYH2_k127_722111_7 COG2801 Transposase and inactivated derivatives K07497 - - 0.0002065 44.0
PYH2_k127_722111_8 PFAM Integrase catalytic region K07497 - - 0.0003166 44.0
PYH2_k127_7223289_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 328.0
PYH2_k127_7223289_1 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000001178 242.0
PYH2_k127_7223289_2 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000003137 236.0
PYH2_k127_7242204_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 622.0
PYH2_k127_7242204_1 HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide K12138,K12139,K15829 GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 337.0
PYH2_k127_7242204_2 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000361 275.0
PYH2_k127_7242204_3 PFAM response regulator receiver K02483,K18344 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000569 259.0
PYH2_k127_7242204_4 hydrogenase 4 membrane K12140 - - 0.000000000000000000000000000000000000000000000000000000000000000000002168 243.0
PYH2_k127_7242204_5 phosphatidate phosphatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000008431 233.0
PYH2_k127_7242204_6 NADH Ubiquinone plastoquinone (Complex I) K12141 - - 0.00000000000000000000000000000002655 130.0
PYH2_k127_7242204_7 RNA-binding protein containing a PIN domain K06962 - - 0.0000000000000000000000000000005042 133.0
PYH2_k127_724692_0 RND efflux system, outer membrane lipoprotein, NodT - - - 0.0000000000000000001776 91.0
PYH2_k127_724692_1 RND efflux system, outer membrane lipoprotein, NodT family - - - 0.000000000000000001357 87.0
PYH2_k127_724692_2 Universal stress protein family - - - 0.00000000000000005198 91.0
PYH2_k127_724692_3 Two component transcriptional regulator, LuxR family K14987 - - 0.00000004758 60.0
PYH2_k127_7268193_0 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 387.0
PYH2_k127_7268193_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 348.0
PYH2_k127_7268193_2 Bacterial type II and III secretion system protein K02453,K03219 - - 0.00000000000000000000000000000000000000002514 158.0
PYH2_k127_7268193_3 - - - - 0.0000000000000000000001421 101.0
PYH2_k127_7268193_4 Bacterial Ig-like domain 2 - - - 0.0005549 53.0
PYH2_k127_7315565_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 5.247e-270 845.0
PYH2_k127_7315565_1 glycolate transport K14393 - - 2.814e-233 735.0
PYH2_k127_7315565_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 336.0
PYH2_k127_7315565_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006365 328.0
PYH2_k127_7315565_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 329.0
PYH2_k127_7315565_5 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002065 234.0
PYH2_k127_7315565_6 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000002244 225.0
PYH2_k127_7315565_7 Protein of unknown function, DUF485 - - - 0.00000000000000000000001268 103.0
PYH2_k127_7315565_8 DNA polymerase III K02342 - 2.7.7.7 0.000000000001256 74.0
PYH2_k127_7315565_9 Tetratricopeptide repeat - - - 0.00002409 54.0
PYH2_k127_7339361_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 377.0
PYH2_k127_7339361_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 350.0
PYH2_k127_7339361_2 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 287.0
PYH2_k127_7339361_3 - - - - 0.0000000000000000000000000000000000000448 151.0
PYH2_k127_7339361_4 mRNA cleavage and polyadenylation factor CLP1 P-loop K06947 - - 0.00000000000000000001865 98.0
PYH2_k127_7339361_5 tyrosine recombinase K04763 - - 0.00000113 52.0
PYH2_k127_7343535_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 297.0
PYH2_k127_7343535_1 Transposase DDE domain K07487 - - 0.000000000002812 73.0
PYH2_k127_7414658_0 Nitrite and sulphite reductase 4Fe-4S K11181 - 1.8.99.5 8.889e-199 622.0
PYH2_k127_7414658_1 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 586.0
PYH2_k127_7422970_0 4Fe-4S dicluster domain - - - 1.456e-278 861.0
PYH2_k127_7422970_1 PFAM Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 426.0
PYH2_k127_7422970_2 part of a sulfur-relay system K11179 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - 0.000000000000000000000000000000000000000000000000006566 184.0
PYH2_k127_7422970_3 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.000000000000000000000000000000000000000000000003132 178.0
PYH2_k127_744327_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 563.0
PYH2_k127_744327_1 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 498.0
PYH2_k127_744327_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 434.0
PYH2_k127_744327_3 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000001503 218.0
PYH2_k127_744327_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000101 160.0
PYH2_k127_744327_6 PFAM Archease protein family (DUF101 UPF0211) - - - 0.00000000000000000000000000000000001602 139.0
PYH2_k127_744327_7 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000001095 132.0
PYH2_k127_7479316_0 SMART Elongator protein 3 MiaB NifB - - - 2.928e-212 668.0
PYH2_k127_7479316_1 Sulphur transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 430.0
PYH2_k127_7479316_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 349.0
PYH2_k127_7479316_4 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000004813 251.0
PYH2_k127_7479316_5 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000008714 206.0
PYH2_k127_7479316_6 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000000000000000000004863 128.0
PYH2_k127_7479316_7 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000000000002534 109.0
PYH2_k127_7479316_8 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000001192 57.0
PYH2_k127_7504372_0 HsdM N-terminal domain K03427 - 2.1.1.72 1.185e-232 725.0
PYH2_k127_7504372_1 COG0732 Restriction endonuclease S subunits K01154 - 3.1.21.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 310.0
PYH2_k127_7504372_2 Fic/DOC family K04095 - - 0.000000000000000000000000000000000000000000000000000000000000000001998 232.0
PYH2_k127_7504372_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000000000000000000000000005482 181.0
PYH2_k127_7504372_4 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.0000000000000000000000000000000000000000003205 160.0
PYH2_k127_7504372_5 Nucleotidyltransferase domain K07075 - - 0.000000000000000000000000002268 114.0
PYH2_k127_7504372_6 - K18829 - - 0.00000000000000000000000001318 110.0
PYH2_k127_7504372_7 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.000000000000000005701 84.0
PYH2_k127_7520475_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1143.0
PYH2_k127_7523028_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.249e-235 744.0
PYH2_k127_7523028_1 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 554.0
PYH2_k127_7523028_2 spermidine synthase activity K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 387.0
PYH2_k127_7523028_3 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 296.0
PYH2_k127_7523028_4 - - - - 0.000000000000000000000001118 112.0
PYH2_k127_7568329_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000903 469.0
PYH2_k127_7568329_1 Pyridoxal-phosphate dependent enzyme K12339,K21148 - 2.5.1.113,2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000003949 252.0
PYH2_k127_7568329_2 cell adhesion K02650 - - 0.00001521 57.0
PYH2_k127_7568329_3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.3 0.00007671 46.0
PYH2_k127_7587946_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 589.0
PYH2_k127_7587946_1 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 381.0
PYH2_k127_7587946_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001372 293.0
PYH2_k127_7587946_3 Helix-turn-helix domain - - - 0.000000000000001889 87.0
PYH2_k127_7587946_4 Domain of unknown function (DUF4388) - - - 0.00000000000001534 87.0
PYH2_k127_7587946_5 DnaJ molecular chaperone homology domain - - - 0.00001377 58.0
PYH2_k127_7587946_6 zinc-ribbon domain - - - 0.00005523 56.0
PYH2_k127_7682643_0 Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 8.286e-204 640.0
PYH2_k127_7682643_1 sister chromatid segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 609.0
PYH2_k127_7682643_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000006098 196.0
PYH2_k127_7682643_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000004424 154.0
PYH2_k127_7682643_4 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000000003322 136.0
PYH2_k127_7682643_5 Cytochrome c K08738 - - 0.000000000000000000000001805 108.0
PYH2_k127_7682643_6 - - - - 0.000000002025 60.0
PYH2_k127_7717745_0 Aconitase C-terminal domain K01681 - 4.2.1.3 2.707e-295 919.0
PYH2_k127_7717745_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 531.0
PYH2_k127_7717745_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000003515 106.0
PYH2_k127_7724084_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 1.254e-234 734.0
PYH2_k127_7724084_1 GAF domain K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 536.0
PYH2_k127_7724084_2 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000000001679 210.0
PYH2_k127_7724084_3 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000003183 191.0
PYH2_k127_7724084_4 Diadenylate cyclase - - - 0.000000000000000000305 89.0
PYH2_k127_787539_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 8.386e-305 943.0
PYH2_k127_787539_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 332.0
PYH2_k127_787539_2 - - - - 0.00000000000000000000000000000001352 136.0
PYH2_k127_787539_3 Histidine triad (Hit) protein - - - 0.000000000001861 72.0
PYH2_k127_787539_4 PFAM thiamineS protein - - - 0.000000008142 63.0
PYH2_k127_787539_5 Histidine triad (Hit) protein - - - 0.00000001197 58.0
PYH2_k127_7906374_0 nitric oxide reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001608 217.0
PYH2_k127_7906374_1 Glycosyl transferase family 2 K09931 - - 0.00000000000000000000000000000000000000000000000000000000005626 212.0
PYH2_k127_7906374_2 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000004064 189.0
PYH2_k127_7906374_3 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000001842 174.0
PYH2_k127_7906374_4 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000168 164.0
PYH2_k127_7906374_5 protein conserved in bacteria K09931 - - 0.00000000000000000000000000000000000001426 153.0
PYH2_k127_7906374_6 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.00000000000002762 75.0
PYH2_k127_7906374_7 Domain of unknown function DUF302 - - - 0.000000000002538 68.0
PYH2_k127_7906374_8 protein histidine kinase activity K10439 - - 0.0000000005288 69.0
PYH2_k127_7972441_0 PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 4.004e-254 801.0
PYH2_k127_7972441_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.985e-222 702.0
PYH2_k127_7972441_10 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 364.0
PYH2_k127_7972441_11 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 344.0
PYH2_k127_7972441_12 metal-dependent phosphohydrolase HD sub K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 356.0
PYH2_k127_7972441_13 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000001044 249.0
PYH2_k127_7972441_14 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000007091 238.0
PYH2_k127_7972441_15 Belongs to the peptidase S8 family K01361 - 3.4.21.96 0.000000000000000000000000000000000000000000000000000000000001842 233.0
PYH2_k127_7972441_16 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000000001579 150.0
PYH2_k127_7972441_17 lipoprotein transporter activity K02003,K09810 - - 0.0000000000000000000000000000006773 123.0
PYH2_k127_7972441_18 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.000000000000000000000000000003315 120.0
PYH2_k127_7972441_19 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000001036 60.0
PYH2_k127_7972441_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 5.558e-196 621.0
PYH2_k127_7972441_20 amine dehydrogenase activity - - - 0.0002764 54.0
PYH2_k127_7972441_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 546.0
PYH2_k127_7972441_4 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 534.0
PYH2_k127_7972441_5 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 493.0
PYH2_k127_7972441_6 S-adenosylhomocysteine deaminase activity K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 472.0
PYH2_k127_7972441_7 HlyD family secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 453.0
PYH2_k127_7972441_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 410.0
PYH2_k127_7972441_9 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 372.0
PYH2_k127_8076506_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2100.0
PYH2_k127_8076506_1 RNA polymerase beta subunit external 1 domain K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1618.0
PYH2_k127_8076506_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000000000008576 194.0
PYH2_k127_8076506_3 Histidine kinase - - - 0.0000000000000000000000000000000000005711 161.0
PYH2_k127_8076506_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000002749 143.0
PYH2_k127_8076506_5 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000005773 120.0
PYH2_k127_8113444_0 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 373.0
PYH2_k127_8113444_1 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005933 269.0
PYH2_k127_8113444_2 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 256.0
PYH2_k127_8113444_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000009545 156.0
PYH2_k127_8121789_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 576.0
PYH2_k127_8121789_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 419.0
PYH2_k127_8121789_2 Mechanosensitive ion channel K03442 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 337.0
PYH2_k127_8121789_3 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 328.0
PYH2_k127_8121789_4 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004085 275.0
PYH2_k127_8121789_5 - - - - 0.0000000000000000000000000000001634 127.0
PYH2_k127_8121789_6 MlaD protein K02067 - - 0.0000000000000000000000000000001845 128.0
PYH2_k127_8151932_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 1.203e-215 677.0
PYH2_k127_8151932_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000545 241.0
PYH2_k127_8151932_2 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000007734 169.0
PYH2_k127_8151932_3 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000006619 72.0
PYH2_k127_8180287_0 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 341.0
PYH2_k127_8180287_1 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005765 257.0
PYH2_k127_8180287_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004222 259.0
PYH2_k127_8226122_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 567.0
PYH2_k127_8226122_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 433.0
PYH2_k127_8226122_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000004878 214.0
PYH2_k127_8226122_3 adenylate kinase activity K00939,K01939 - 2.7.4.3,6.3.4.4 0.0000000000000000000000000000000000000000000001217 177.0
PYH2_k127_8226122_4 thiamine diphosphate biosynthetic process K03154 - - 0.00000000000002822 74.0
PYH2_k127_8395837_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.691e-214 675.0
PYH2_k127_8395837_1 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000007003 226.0
PYH2_k127_8395837_2 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000001138 216.0
PYH2_k127_8395837_3 Response regulator receiver - - - 0.000000000000000000000000000000000000000002863 160.0
PYH2_k127_8413538_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000004119 240.0
PYH2_k127_8413538_1 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000001991 199.0
PYH2_k127_8417204_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 524.0
PYH2_k127_8417204_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 501.0
PYH2_k127_8417204_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 476.0
PYH2_k127_8417204_3 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 387.0
PYH2_k127_8417204_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 339.0
PYH2_k127_8417204_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002231 269.0
PYH2_k127_8417204_6 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000001477 235.0
PYH2_k127_8417204_7 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000003461 215.0
PYH2_k127_8417204_8 regulator, PATAN and FRGAF domain-containing - - - 0.00000000000000000000000000000000000000002256 168.0
PYH2_k127_8464684_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1114.0
PYH2_k127_8464684_1 PFAM AICARFT IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 612.0
PYH2_k127_8464684_2 isocitrate dehydrogenase activity K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 573.0
PYH2_k127_8464684_3 HD domain K07023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008475 272.0
PYH2_k127_8464684_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000003003 246.0
PYH2_k127_8464684_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000143 216.0
PYH2_k127_8464684_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000005442 80.0
PYH2_k127_8469797_0 Bacterial regulatory protein, Fis family K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 528.0
PYH2_k127_8469797_1 GHKL domain K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 524.0
PYH2_k127_8469797_2 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001054 255.0
PYH2_k127_8469797_3 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000001393 170.0
PYH2_k127_8469797_4 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000000002265 166.0
PYH2_k127_8469797_6 Histidine biosynthesis bifunctional protein hisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000002269 106.0
PYH2_k127_8469797_7 FAD binding domain K00278 - 1.4.3.16 0.0000000000000000005572 90.0
PYH2_k127_8479716_0 Belongs to the peptidase S16 family K01338,K04076 - 3.4.21.53 0.0 1046.0
PYH2_k127_8479716_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.598e-202 642.0
PYH2_k127_8479716_10 sister chromatid segregation - - - 0.000000000000000000000000107 108.0
PYH2_k127_8479716_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 543.0
PYH2_k127_8479716_3 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 340.0
PYH2_k127_8479716_4 PFAM lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000002406 242.0
PYH2_k127_8479716_5 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000131 187.0
PYH2_k127_8479716_6 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000000000000141 167.0
PYH2_k127_8479716_7 radical SAM K06871 - - 0.00000000000000000000000000000000000001045 157.0
PYH2_k127_8479716_8 Sulphur transport K07112 - - 0.00000000000000000000000000000000000001344 154.0
PYH2_k127_8479716_9 - K07112 - - 0.0000000000000000000000000000000000001807 147.0
PYH2_k127_8492522_0 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 5.562e-206 648.0
PYH2_k127_8492522_1 Belongs to the heme-copper respiratory oxidase family K00404,K15862 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 560.0
PYH2_k127_8492522_2 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 470.0
PYH2_k127_8492522_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000009569 198.0
PYH2_k127_8492522_4 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000003223 139.0
PYH2_k127_8492522_5 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.0000000000000000000000000000000003137 138.0
PYH2_k127_8492522_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000003635 79.0
PYH2_k127_8569489_0 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 542.0
PYH2_k127_8569489_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 353.0
PYH2_k127_8569489_2 Membrane-bound lysozyme-inhibitor of c-type lysozyme - - - 0.000000000000000000000000000000000000000000000000000000000009254 211.0
PYH2_k127_8569489_3 SpoIIAA-like - - - 0.00000000000000000000004163 103.0
PYH2_k127_8574137_0 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 8.509e-217 685.0
PYH2_k127_8574137_1 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001572 256.0
PYH2_k127_8574137_2 Flavin containing amine oxidoreductase K09835 - 5.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000008084 258.0
PYH2_k127_8574137_3 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000003698 96.0
PYH2_k127_8574137_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000001939 79.0
PYH2_k127_8574137_5 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.0002039 48.0
PYH2_k127_8637105_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 4.72e-221 691.0
PYH2_k127_8637105_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.984e-194 620.0
PYH2_k127_8637105_10 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 329.0
PYH2_k127_8637105_11 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 323.0
PYH2_k127_8637105_12 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 306.0
PYH2_k127_8637105_13 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 301.0
PYH2_k127_8637105_14 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 292.0
PYH2_k127_8637105_15 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002571 281.0
PYH2_k127_8637105_16 HEAT repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001077 287.0
PYH2_k127_8637105_17 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002031 263.0
PYH2_k127_8637105_18 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000006159 240.0
PYH2_k127_8637105_19 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000000000007285 201.0
PYH2_k127_8637105_2 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005037 504.0
PYH2_k127_8637105_20 Response regulator receiver domain K03413 - - 0.00000000000000000000000000000000000000000001218 165.0
PYH2_k127_8637105_21 PFAM CheW-like domain K03408 - - 0.0000000000000000000000001287 110.0
PYH2_k127_8637105_22 bacterial (prokaryotic) histone like domain K05788 - - 0.0000000000000000000000006736 106.0
PYH2_k127_8637105_23 PFAM RNA recognition motif - - - 0.00000000000000000000006114 102.0
PYH2_k127_8637105_24 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000001087 75.0
PYH2_k127_8637105_25 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0004566 43.0
PYH2_k127_8637105_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 483.0
PYH2_k127_8637105_4 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 478.0
PYH2_k127_8637105_5 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 435.0
PYH2_k127_8637105_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 427.0
PYH2_k127_8637105_7 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 433.0
PYH2_k127_8637105_8 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 413.0
PYH2_k127_8637105_9 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 355.0
PYH2_k127_8641039_0 Bacterial type II and III secretion system protein K02453,K03219 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 305.0
PYH2_k127_8641039_1 polysaccharide export K01991 - - 0.000000004182 65.0
PYH2_k127_8669433_0 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 563.0
PYH2_k127_8669433_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009359 471.0
PYH2_k127_8669433_10 overlaps another CDS with the same product name - - - 0.00000000000000000000000000000000000000442 156.0
PYH2_k127_8669433_11 Stringent starvation protein B K09985 - - 0.000000000000000000000000000000009863 131.0
PYH2_k127_8669433_12 Protein of unknown function, DUF393 - - - 0.000000000000000000000000005485 115.0
PYH2_k127_8669433_13 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.0000000000000000000000001402 110.0
PYH2_k127_8669433_14 response regulator receiver - - - 0.00000000000000105 90.0
PYH2_k127_8669433_15 KR domain - - - 0.000000008018 62.0
PYH2_k127_8669433_16 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.000005206 49.0
PYH2_k127_8669433_17 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00005127 46.0
PYH2_k127_8669433_2 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 452.0
PYH2_k127_8669433_3 PFAM peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 405.0
PYH2_k127_8669433_4 ABC transporter (Permease K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009761 347.0
PYH2_k127_8669433_5 Binding-protein-dependent transport system inner membrane component K02025,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009921 352.0
PYH2_k127_8669433_6 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000002436 270.0
PYH2_k127_8669433_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009799 253.0
PYH2_k127_8669433_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000001171 210.0
PYH2_k127_8669433_9 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.0000000000000000000000000000000000000001042 153.0
PYH2_k127_8724064_0 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 534.0
PYH2_k127_8724064_1 PFAM 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 379.0
PYH2_k127_8724064_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003333 272.0
PYH2_k127_8724064_3 Diguanylate cyclase K21084 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000913 279.0
PYH2_k127_8803179_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 470.0
PYH2_k127_8803179_1 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 304.0
PYH2_k127_8803179_2 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
PYH2_k127_8803179_3 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000005481 215.0
PYH2_k127_8803179_4 Putative beta-barrel porin 2 - - - 0.0000000000000000000000002732 113.0
PYH2_k127_8808460_0 Ftsk_gamma K03466 - - 2.929e-199 644.0
PYH2_k127_8808460_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 608.0
PYH2_k127_8808460_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 402.0
PYH2_k127_8808460_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 286.0
PYH2_k127_8808460_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000008365 59.0
PYH2_k127_8869311_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 2.647e-216 681.0
PYH2_k127_8869311_1 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 497.0
PYH2_k127_8869311_2 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 417.0
PYH2_k127_8869311_3 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 387.0
PYH2_k127_8869311_4 retrograde transport, endosome to Golgi K07095 - - 0.000000000000000000000000000000000000000000000000002549 186.0
PYH2_k127_8869311_5 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000001236 158.0
PYH2_k127_8869311_6 Chromate K07240 - - 0.000000000000000006517 87.0
PYH2_k127_8934825_0 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 541.0
PYH2_k127_8934825_1 membrane-bound metal-dependent K07038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001325 286.0
PYH2_k127_8934825_2 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000004503 241.0
PYH2_k127_8934825_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K04068,K10026 - 1.97.1.4,4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000004009 235.0
PYH2_k127_8934825_4 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.000004491 55.0
PYH2_k127_9008512_0 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 539.0
PYH2_k127_9008512_1 phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 432.0
PYH2_k127_9008512_2 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 314.0
PYH2_k127_9008512_3 AsmA-like C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007907 313.0
PYH2_k127_9008512_4 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000000000000000000006014 222.0
PYH2_k127_9008512_5 Protein of unknown function (DUF3141) - - - 0.0000000000000000003711 92.0
PYH2_k127_902659_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 4.745e-227 713.0
PYH2_k127_902659_1 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 554.0
PYH2_k127_902659_10 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.0000000001288 66.0
PYH2_k127_902659_11 TIGRFAM thioredoxin K03672 - 1.8.1.8 0.0008665 48.0
PYH2_k127_902659_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 541.0
PYH2_k127_902659_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 430.0
PYH2_k127_902659_4 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 359.0
PYH2_k127_902659_5 zinc ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003224 263.0
PYH2_k127_902659_6 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000002166 159.0
PYH2_k127_902659_7 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000001799 150.0
PYH2_k127_902659_8 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.000000000000000000000000000128 123.0
PYH2_k127_902659_9 Tetratricopeptide repeat-like domain - - - 0.00000000000000003302 90.0
PYH2_k127_903610_0 Cytochrome c554 and c-prime - - - 0.0 1139.0
PYH2_k127_903610_1 Arylsulfatase a - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 585.0
PYH2_k127_903610_2 oxidation-reduction process - - - 0.00000000000000000000000000000000000000001708 168.0
PYH2_k127_9066302_0 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 379.0
PYH2_k127_9066302_1 4Fe-4S double cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001726 222.0
PYH2_k127_9066302_10 DsrE/DsrF-like family K07092 - - 0.00002999 51.0
PYH2_k127_9066302_11 Histidine kinase A domain protein - - - 0.0000323 54.0
PYH2_k127_9066302_12 Pentapeptide repeats (9 copies) - - - 0.0008097 47.0
PYH2_k127_9066302_2 PFAM thioesterase superfamily protein - - - 0.00000000000000000000000000000000000000000005904 163.0
PYH2_k127_9066302_3 Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000000000000008656 172.0
PYH2_k127_9066302_4 (twin-arginine translocation) pathway signal - - - 0.000000000000000000000000000000000000000002935 162.0
PYH2_k127_9066302_5 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.00000000000000000000000000000000003245 143.0
PYH2_k127_9066302_6 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000000000006042 136.0
PYH2_k127_9066302_8 TfoX N-terminal domain - - - 0.00000000000000000000003384 102.0
PYH2_k127_9066302_9 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000008058 106.0
PYH2_k127_9074143_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 405.0
PYH2_k127_9074143_1 surface antigen variable number repeat protein K07001 - - 0.000000000000000000000000000000000000000000000000000000000000005699 226.0
PYH2_k127_9074143_2 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000001539 78.0
PYH2_k127_9074143_3 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000226 78.0
PYH2_k127_9152888_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 1.767e-223 717.0
PYH2_k127_9152888_1 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 313.0
PYH2_k127_9152888_3 PFAM Formylglycine-generating sulfatase enzyme K18912 - 1.14.99.50 0.00000000229 65.0
PYH2_k127_916126_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.895e-238 748.0
PYH2_k127_916126_1 Elongation factor SelB, winged helix K03833 - - 6.019e-207 662.0
PYH2_k127_916126_10 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000009227 179.0
PYH2_k127_916126_11 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000001224 162.0
PYH2_k127_916126_12 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000007806 152.0
PYH2_k127_916126_13 Membrane - - - 0.00000000000000000000000000000001936 132.0
PYH2_k127_916126_14 MgtC family K07507 - - 0.00000000000000000000000000000002066 131.0
PYH2_k127_916126_15 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000000164 126.0
PYH2_k127_916126_17 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000166 54.0
PYH2_k127_916126_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 509.0
PYH2_k127_916126_3 L-seryl-tRNASec selenium transferase activity K01042 GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 454.0
PYH2_k127_916126_4 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 415.0
PYH2_k127_916126_5 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 361.0
PYH2_k127_916126_6 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004925 277.0
PYH2_k127_916126_7 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000004495 263.0
PYH2_k127_916126_8 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000001033 188.0
PYH2_k127_9183477_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.874e-198 630.0
PYH2_k127_9183477_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 473.0
PYH2_k127_9183477_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
PYH2_k127_9183477_3 Cupin domain - - - 0.0000000000000000000000000001197 119.0
PYH2_k127_9183477_4 sensor histidine kinase - - - 0.00000000000000000000724 109.0
PYH2_k127_9202641_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1669.0
PYH2_k127_9202641_1 ABC transporter K06020 - 3.6.3.25 1.861e-307 947.0
PYH2_k127_9202641_10 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000002329 198.0
PYH2_k127_9202641_11 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000003809 128.0
PYH2_k127_9202641_12 Part of a membrane complex involved in electron transport K03612 - - 0.000000000000000000000001589 111.0
PYH2_k127_9202641_13 spore germination - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000313 99.0
PYH2_k127_9202641_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 4.52e-206 653.0
PYH2_k127_9202641_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 4.015e-195 616.0
PYH2_k127_9202641_4 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 505.0
PYH2_k127_9202641_5 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 359.0
PYH2_k127_9202641_6 Putative Fe-S cluster K03616 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009052 344.0
PYH2_k127_9202641_7 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000105 235.0
PYH2_k127_9202641_8 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000005132 236.0
PYH2_k127_9202641_9 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000001885 207.0
PYH2_k127_9205011_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 5.771e-199 625.0
PYH2_k127_9205011_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 411.0
PYH2_k127_9205011_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 407.0
PYH2_k127_9205011_3 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 364.0
PYH2_k127_9205011_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000000227 273.0
PYH2_k127_9205011_5 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000001583 185.0
PYH2_k127_9205011_6 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000001647 104.0
PYH2_k127_9205011_7 DUF218 domain - - - 0.0000000000000000000005846 102.0
PYH2_k127_9215205_0 Phosphoglycerate kinase K00927 - 2.7.2.3 5.034e-194 612.0
PYH2_k127_9215205_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 491.0
PYH2_k127_9215205_10 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000009731 102.0
PYH2_k127_9215205_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 485.0
PYH2_k127_9215205_3 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 446.0
PYH2_k127_9215205_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 430.0
PYH2_k127_9215205_5 Peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 410.0
PYH2_k127_9215205_6 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 349.0
PYH2_k127_9215205_7 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000000000000000000000000000000003744 210.0
PYH2_k127_9215205_8 CHASE K02488,K21009 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000004357 196.0
PYH2_k127_9215205_9 Type II restriction enzyme, methylase - - - 0.000000000000000000000000000004871 124.0
PYH2_k127_9234871_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.235e-217 681.0
PYH2_k127_9234871_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 453.0
PYH2_k127_9234871_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 446.0
PYH2_k127_9234871_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 419.0
PYH2_k127_9234871_4 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 322.0
PYH2_k127_9234871_5 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000134 261.0
PYH2_k127_9238017_0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 514.0
PYH2_k127_9238017_1 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000007404 205.0
PYH2_k127_9238017_2 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000002217 162.0
PYH2_k127_9238017_3 TIGRFAM hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000003081 146.0
PYH2_k127_924258_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000005859 186.0
PYH2_k127_924258_1 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000004546 159.0
PYH2_k127_924258_2 MGS-like domain - - - 0.00000000000000000000000000000000001029 142.0
PYH2_k127_924258_3 - - - - 0.000000000000001121 84.0
PYH2_k127_924258_4 Tetratricopeptide repeat - - - 0.00000728 58.0
PYH2_k127_924608_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.926e-285 899.0
PYH2_k127_924608_1 DNA polymerase A domain K02335 - 2.7.7.7 5.05e-263 837.0
PYH2_k127_924608_10 assembly protein PilO K02664 - - 0.00000000000001477 81.0
PYH2_k127_924608_11 Pilus assembly protein, PilP K02665 - - 0.000000000005112 74.0
PYH2_k127_924608_12 Fimbrial assembly protein (PilN) K02663 - - 0.000000001555 66.0
PYH2_k127_924608_13 Protein of unknown function (DUF721) - - - 0.0000002782 59.0
PYH2_k127_924608_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 583.0
PYH2_k127_924608_3 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 339.0
PYH2_k127_924608_4 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 324.0
PYH2_k127_924608_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001613 281.0
PYH2_k127_924608_6 phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000001084 244.0
PYH2_k127_924608_7 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000001205 237.0
PYH2_k127_924608_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000005092 116.0
PYH2_k127_924608_9 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000004606 86.0
PYH2_k127_968630_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 389.0
PYH2_k127_968630_1 nucleoside-triphosphate diphosphatase activity K06287 - - 0.000000000000000000000000000000000000000000000005083 179.0
PYH2_k127_968630_2 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000004793 156.0
PYH2_k127_968630_3 conserved protein UCP033924 - - - 0.000000000000000000000000000000000001319 143.0
PYH2_k127_971025_0 Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000000000000000000000000003357 220.0
PYH2_k127_971025_1 PAS fold - - - 0.000000000000000000000000000000000000000009264 166.0
PYH2_k127_971025_2 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000004463 151.0
PYH2_k127_971025_3 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000002257 141.0
PYH2_k127_971025_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000816 145.0
PYH2_k127_971025_5 Belongs to the UPF0251 family - - - 0.00000000000000000000000001583 111.0
PYH2_k127_975982_0 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 6.81e-235 742.0
PYH2_k127_975982_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 360.0
PYH2_k127_975982_10 LemA family K03744 - - 0.0000000000000000000000000000000000000000000009437 171.0
PYH2_k127_975982_11 Protein of unknown function (DUF1255) K09913 - 2.4.2.1,2.4.2.2 0.000000000000000000000000000000000000000000753 158.0
PYH2_k127_975982_12 PFAM Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000009619 162.0
PYH2_k127_975982_13 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000000004793 108.0
PYH2_k127_975982_14 Putative regulatory protein - - - 0.00000000000000000000002744 102.0
PYH2_k127_975982_15 response regulator receiver K07814 - - 0.000000000009878 74.0
PYH2_k127_975982_2 PFAM ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 344.0
PYH2_k127_975982_3 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 314.0
PYH2_k127_975982_4 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007325 301.0
PYH2_k127_975982_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000292 267.0
PYH2_k127_975982_6 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000000000000000000000000000001788 220.0
PYH2_k127_975982_7 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000000000000000000000000001065 184.0
PYH2_k127_975982_8 Cache domain - - - 0.000000000000000000000000000000000000000000000002286 179.0
PYH2_k127_975982_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000003456 176.0