Overview

ID MAG03209
Name PYH2_bin.68
Sample SMP0074
Taxonomy
Kingdom Archaea
Phylum Thermoplasmatota
Class Thermoplasmata
Order RBG-16-68-12
Family RBG-16-68-12
Genus EA-19
Species
Assembly information
Completeness (%) 58.99
Contamination (%) 1.0
GC content (%) 68.0
N50 (bp) 4,489
Genome size (bp) 1,174,126

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1122

Gene name Description KEGG GOs EC E-value Score Sequence
PYH2_k127_1009845_0 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 7.324e-231 789.0
PYH2_k127_1009845_1 - - - - 0.000000001543 68.0
PYH2_k127_1009845_2 Trm112p-like protein - - - 0.0000006017 63.0
PYH2_k127_1081576_0 4Fe-4S dicluster domain K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000005242 262.0
PYH2_k127_1091360_0 PFAM Glycosyl transferase family 4 K01001 - 2.7.8.15 0.0000000000000000000000000000000000000000000000000000000001214 215.0
PYH2_k127_1091360_1 Oligosaccharide biosynthesis protein Alg14 like - - - 0.00000000000000000000001569 105.0
PYH2_k127_1093614_0 Ribosomal protein L11 methyltransferase (PrmA) K07579 - - 0.000000000000000000000000000000000000000000000000000000007434 207.0
PYH2_k127_1093614_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000000000000000000000000000000000000005378 176.0
PYH2_k127_1093614_2 SMART Ras small GTPase, Ras type - - - 0.000000000000000000000000000449 123.0
PYH2_k127_1094753_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 549.0
PYH2_k127_1094753_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 314.0
PYH2_k127_1094753_2 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000005546 225.0
PYH2_k127_1094753_3 Thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000003959 163.0
PYH2_k127_1094753_4 Membrane - - - 0.00000000000000000000000000000002694 136.0
PYH2_k127_1117425_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 536.0
PYH2_k127_1117425_1 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000002044 175.0
PYH2_k127_1117425_2 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000000000000002037 163.0
PYH2_k127_1131283_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 419.0
PYH2_k127_1131283_1 COGs COG4328 conserved - - - 0.000000000000000000000000000000000000000000000000000501 196.0
PYH2_k127_1131283_2 - - - - 0.000000000003997 70.0
PYH2_k127_1131283_3 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000005596 66.0
PYH2_k127_1131283_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000002693 62.0
PYH2_k127_1131283_5 acid acetyltransferase K06718 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 2.3.1.178 0.0000004235 60.0
PYH2_k127_1131283_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000001464 51.0
PYH2_k127_1131283_7 PIN domain - - - 0.0001576 49.0
PYH2_k127_1195742_0 COG1233 Phytoene dehydrogenase and related proteins K10027,K20611 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 592.0
PYH2_k127_1195742_1 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 296.0
PYH2_k127_1195742_2 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases K20616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008152 264.0
PYH2_k127_1195742_3 protein conserved in bacteria - - - 0.00000000000000000000000000005473 120.0
PYH2_k127_1195742_4 TspO/MBR family K05770 - - 0.0000000000000000000002483 98.0
PYH2_k127_1214734_0 GvpD gas vesicle protein - - - 0.000000000000000000000000000000000001472 154.0
PYH2_k127_1214734_1 KaiC K08482 - - 0.0000000000002336 75.0
PYH2_k127_12195_0 DEAD DEAH box helicase domain protein K10896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 473.0
PYH2_k127_12195_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 326.0
PYH2_k127_12195_2 PFAM Aminotransferase, class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009794 275.0
PYH2_k127_12195_3 TIGRFAM conserved repeat domain - - - 0.00000000000000000000000000000000000000003702 175.0
PYH2_k127_12195_4 - - - - 0.000000000000000000000000000000000005709 148.0
PYH2_k127_1278548_0 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 452.0
PYH2_k127_1278548_1 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000001753 121.0
PYH2_k127_1292570_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 428.0
PYH2_k127_1292570_1 Sulfurtransferase TusA - - - 0.000000000000002591 76.0
PYH2_k127_1316012_0 4Fe-4S single cluster domain K07129 - - 0.0000000000000000000000000008005 120.0
PYH2_k127_1374037_0 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000953 206.0
PYH2_k127_1374037_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000001 138.0
PYH2_k127_1381868_0 Peptidase M16 domain protein K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007334 323.0
PYH2_k127_1381868_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000001846 104.0
PYH2_k127_1381868_2 PFAM Peptidase M16 inactive domain K07263 - - 0.00004286 49.0
PYH2_k127_1387686_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000002872 184.0
PYH2_k127_1387686_1 response to heat K07090 - - 0.00000000001101 72.0
PYH2_k127_1391556_0 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000009903 272.0
PYH2_k127_1391556_1 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000001017 191.0
PYH2_k127_1391556_2 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000001031 85.0
PYH2_k127_1391556_3 aminopeptidase activity - - - 0.0000000000000004814 87.0
PYH2_k127_1421899_0 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 393.0
PYH2_k127_1421899_1 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001113 230.0
PYH2_k127_1465305_0 - - - - 0.0000000000000000000000000000000000000000003876 169.0
PYH2_k127_1465305_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000002574 147.0
PYH2_k127_1467172_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 4.717e-197 630.0
PYH2_k127_1467172_1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 320.0
PYH2_k127_1467172_2 serine-type endopeptidase activity - - - 0.00000000000000000000000000000000000000002189 164.0
PYH2_k127_1467172_3 EamA-like transporter family - - - 0.0000000002257 72.0
PYH2_k127_1467172_4 PFAM S-layer - - - 0.000000002118 61.0
PYH2_k127_1524307_0 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 454.0
PYH2_k127_1524307_1 exo-alpha-(2->6)-sialidase activity - - - 0.00000000003908 73.0
PYH2_k127_1524307_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000897 53.0
PYH2_k127_1552538_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000005163 267.0
PYH2_k127_1552538_1 pyruvate synthase activity K00172,K00189 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000003189 127.0
PYH2_k127_1552538_2 COG1522 Transcriptional regulators - - - 0.000003105 54.0
PYH2_k127_1575715_0 AAA domain K01338 - 3.4.21.53 1.649e-198 630.0
PYH2_k127_1575715_1 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 302.0
PYH2_k127_1575715_2 Pfam:Methyltransf_26 K07446 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 0.0000000000000000000000000000000000000000000000001146 190.0
PYH2_k127_1575715_3 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000000000005172 124.0
PYH2_k127_1575715_4 VIT family - - - 0.000000000000000000000000185 114.0
PYH2_k127_1575715_5 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000003709 85.0
PYH2_k127_1586729_0 PFAM MazG nucleotide pyrophosphohydrolase domain - - - 0.000000000000000000000000001783 117.0
PYH2_k127_1586729_1 Protein of unknown function (DUF1616) - - - 0.0000000000000000001983 96.0
PYH2_k127_1586729_2 KaiC - - - 0.00000000000000000685 94.0
PYH2_k127_1586729_3 RNase_H superfamily K07502 - - 0.000000000002306 68.0
PYH2_k127_1611294_0 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000001978 218.0
PYH2_k127_1611294_1 Fcf1 K07158 - - 0.00000000000000000007974 94.0
PYH2_k127_1611294_2 - - - - 0.000000000000000003507 96.0
PYH2_k127_1670819_0 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000001335 239.0
PYH2_k127_1670819_1 COG3407 Mevalonate pyrophosphate decarboxylase K17942 - 4.1.1.99 0.00000000000000000000000000000000000003076 148.0
PYH2_k127_1673387_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 395.0
PYH2_k127_1673387_1 PFAM sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000005671 221.0
PYH2_k127_1673387_2 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.00000000000000000000000000000000000000000000000000000008392 201.0
PYH2_k127_1673387_3 Phosphorylase superfamily K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.00000000000000000000000000000000000000000000000000001008 198.0
PYH2_k127_1673387_4 Protein of unknown function (DUF835) - - - 0.00004876 49.0
PYH2_k127_1681839_0 Belongs to the MEMO1 family K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 316.0
PYH2_k127_1681839_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000002096 187.0
PYH2_k127_1681839_2 - - - - 0.00000006724 56.0
PYH2_k127_1761803_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 364.0
PYH2_k127_1761803_1 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000006092 165.0
PYH2_k127_1761803_2 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.000000000000000000000000000005803 123.0
PYH2_k127_1761803_3 - - - - 0.0000000000000000007532 91.0
PYH2_k127_1780379_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 526.0
PYH2_k127_1830770_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 2.708e-244 774.0
PYH2_k127_1830770_1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 K03049 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000001489 225.0
PYH2_k127_1830770_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000001178 223.0
PYH2_k127_1830770_3 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000001531 107.0
PYH2_k127_1830770_4 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000005229 92.0
PYH2_k127_1830770_5 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.0000000000000000007453 89.0
PYH2_k127_1859148_0 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007262 482.0
PYH2_k127_1859148_1 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000006082 113.0
PYH2_k127_1859148_2 BNR repeat-like domain K05989 - 3.2.1.40 0.00000000000002118 88.0
PYH2_k127_1859148_3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000001701 72.0
PYH2_k127_1871311_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 321.0
PYH2_k127_1871311_1 ABC-type dipeptide transport system periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002924 280.0
PYH2_k127_1871311_2 DUF72 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003765 273.0
PYH2_k127_1871311_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000006346 79.0
PYH2_k127_1876577_0 COG1012 NAD-dependent aldehyde dehydrogenases K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 498.0
PYH2_k127_1876577_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 355.0
PYH2_k127_1876577_2 DNA binding protein K06930 - - 0.00000000000000000000000000000000008483 147.0
PYH2_k127_1899873_0 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 289.0
PYH2_k127_1899873_1 Domain of unknown function DUF87 K06915 - - 0.000000000000000000000000000000000000000000000000000000000000005777 236.0
PYH2_k127_1899873_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000007563 86.0
PYH2_k127_1899873_3 COG0419 ATPase involved in DNA repair K03546 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006260,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576 - 0.000000000002747 81.0
PYH2_k127_1899873_4 NurA - - - 0.00002849 57.0
PYH2_k127_1922071_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K00342,K05568 - 1.6.5.3 0.0 1124.0
PYH2_k127_1922071_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 575.0
PYH2_k127_1922071_2 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001553 259.0
PYH2_k127_1922071_3 TIGRFAM indolepyruvate ferredoxin oxidoreductase, beta subunit K00180 - 1.2.7.8 0.00000000000000000000000000000001897 147.0
PYH2_k127_1922071_4 EamA-like transporter family - - - 0.000000000000000000000000009975 121.0
PYH2_k127_1922071_5 - - - - 0.0000000000002454 82.0
PYH2_k127_1922071_6 Multisubunit Na H antiporter MnhC subunit K00340,K05567,K14114 - 1.6.5.3 0.0000001736 60.0
PYH2_k127_1939711_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000004285 242.0
PYH2_k127_1939711_1 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000000000000000003882 140.0
PYH2_k127_1939711_2 PFAM Glycosyl transferase, group 1 K00743 - 2.4.1.87 0.00000000000001394 76.0
PYH2_k127_1939927_0 Catalyzes the formation of L-threonine from O-phospho-L-homoserine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 366.0
PYH2_k127_1939927_1 tRNA processing K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000003547 231.0
PYH2_k127_1939927_2 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.000000000000000000000000000000000004681 155.0
PYH2_k127_1939927_3 Parallel beta-helix repeat K07218 - - 0.000000000000000000003323 106.0
PYH2_k127_1968522_0 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 5.689e-209 672.0
PYH2_k127_1968522_1 PFAM Histone deacetylase K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 333.0
PYH2_k127_1968522_2 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 0.000000000000000000000000000000000000000000000000000000001864 216.0
PYH2_k127_1968522_3 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000001191 213.0
PYH2_k127_1968522_4 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000001438 198.0
PYH2_k127_1968522_5 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000001347 126.0
PYH2_k127_1968522_6 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000224 107.0
PYH2_k127_1968522_7 Transcriptional regulator K05804,K13652,K13653 - - 0.000000000000000002973 92.0
PYH2_k127_1968522_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000001332 73.0
PYH2_k127_1968522_9 - - - - 0.0000001311 61.0
PYH2_k127_1993349_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000001486 175.0
PYH2_k127_1993349_1 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000001402 162.0
PYH2_k127_1993349_2 ribonuclease activity K07060 - - 0.0000000000000000000000000000000135 132.0
PYH2_k127_1993349_3 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.89 0.00000000006159 62.0
PYH2_k127_1993349_4 - K21029 - 2.7.7.80 0.0004865 51.0
PYH2_k127_1994463_0 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 371.0
PYH2_k127_1994463_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000004773 268.0
PYH2_k127_1994463_2 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001844 252.0
PYH2_k127_1994463_3 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000005552 83.0
PYH2_k127_1994463_4 - - - - 0.00000000000332 70.0
PYH2_k127_1995850_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 2.606e-273 849.0
PYH2_k127_1995850_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 339.0
PYH2_k127_1995850_2 PFAM Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000003405 229.0
PYH2_k127_1995850_3 Glycerol-3-phosphate dehydrogenase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000003025 203.0
PYH2_k127_1995850_4 Protein of unknown function (DUF981) K08980 - - 0.00000000000000000000000000000000002478 147.0
PYH2_k127_1995850_5 Pkd domain containing protein - - - 0.00000000000005477 83.0
PYH2_k127_2009295_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.558e-230 733.0
PYH2_k127_2009295_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.0000000000000000000000000000000000000000000000000000000000002691 218.0
PYH2_k127_2009295_2 Major facilitator superfamily - - - 0.000000000000000000000000000002405 136.0
PYH2_k127_2009295_3 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000008253 134.0
PYH2_k127_2068291_0 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000007814 130.0
PYH2_k127_2068291_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000001367 120.0
PYH2_k127_2068291_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000001232 78.0
PYH2_k127_2068291_3 peptidase M36 K01417 - - 0.000004306 60.0
PYH2_k127_2068291_4 repeat protein - - - 0.00005466 56.0
PYH2_k127_2142256_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 8.756e-242 758.0
PYH2_k127_2142256_1 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000006718 204.0
PYH2_k127_2142256_2 GTPase activity K07588 - - 0.000000000000000000000000000000000000000000000000008557 184.0
PYH2_k127_2142256_3 SMART Ras small GTPase, Ras type - - - 0.000000000000000000000000000005448 126.0
PYH2_k127_2142256_4 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000001181 54.0
PYH2_k127_2193784_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 360.0
PYH2_k127_2193784_1 LemA family K03744 - - 0.00000000000000000000000000000000000623 144.0
PYH2_k127_2193784_2 TPM domain K06872 - - 0.000000000000000000000000000003132 128.0
PYH2_k127_2193784_3 cellulase activity K07019 - - 0.0000000000003645 81.0
PYH2_k127_2193784_4 KEOPS complex Cgi121-like subunit K09119 - - 0.0000000000004097 76.0
PYH2_k127_2249598_0 MMPL family K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 377.0
PYH2_k127_2249598_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000003368 184.0
PYH2_k127_2251210_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 4.279e-240 752.0
PYH2_k127_2251210_1 PFAM Conserved carboxylase region K01571,K01960 - 4.1.1.3,6.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 556.0
PYH2_k127_2252807_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.09e-230 724.0
PYH2_k127_2252807_1 Domain of unknown function DUF87 - - - 0.00006711 46.0
PYH2_k127_2255766_0 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 362.0
PYH2_k127_2255766_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000002881 268.0
PYH2_k127_2255766_2 LUD domain - - - 0.0000000000000000000000000000000000000002776 156.0
PYH2_k127_2323947_0 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000002566 233.0
PYH2_k127_2323947_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000003363 184.0
PYH2_k127_2323947_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000008619 149.0
PYH2_k127_2323947_3 PFAM 4-vinyl reductase, 4VR K07013 - - 0.00000000000001218 79.0
PYH2_k127_2323947_4 Roadblock LC7 family protein K07131 - - 0.000000000009191 72.0
PYH2_k127_2329155_0 PP-loop family K21947 - 2.8.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001138 278.0
PYH2_k127_2329155_1 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0000000000000000000000004782 114.0
PYH2_k127_2339398_0 methyltransferase small K00564 - 2.1.1.172 0.0000000000000000000000000000000000000000000000000000002917 201.0
PYH2_k127_2339398_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000001115 169.0
PYH2_k127_2339398_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000006194 109.0
PYH2_k127_2345681_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.000000000000000000000000000000000000000000000002113 176.0
PYH2_k127_2345681_1 - - - - 0.00005266 52.0
PYH2_k127_2350749_0 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000276 133.0
PYH2_k127_2350749_1 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0004157 50.0
PYH2_k127_2366745_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 389.0
PYH2_k127_2366745_1 Participates in transcription termination K02600 - - 0.000000000000000000000000000000000000000000009719 166.0
PYH2_k127_2366745_2 Belongs to the UPF0145 family - - - 0.00000000000000000000000000351 114.0
PYH2_k127_2366745_3 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000002228 95.0
PYH2_k127_2418761_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000121 236.0
PYH2_k127_2422123_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044,K13798 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1494.0
PYH2_k127_2422123_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 1.394e-265 854.0
PYH2_k127_2467297_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 556.0
PYH2_k127_2467297_1 COG1361 S-layer domain - - - 0.000000009917 64.0
PYH2_k127_2468050_0 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.00000000000000000000000000004047 126.0
PYH2_k127_2468050_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.00000000000000000008732 93.0
PYH2_k127_2468050_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - 0.000000005009 66.0
PYH2_k127_2512217_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 392.0
PYH2_k127_2512217_1 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000001287 247.0
PYH2_k127_256465_0 ATPases associated with a variety of cellular activities K01990,K11050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006882 325.0
PYH2_k127_256465_1 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000009211 168.0
PYH2_k127_256465_2 thimet oligopeptidase K01392,K01393 GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564 3.4.24.15,3.4.24.16 0.000006658 50.0
PYH2_k127_2607483_0 PFAM Radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 493.0
PYH2_k127_2607483_1 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 358.0
PYH2_k127_2607483_2 PFAM Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000002451 223.0
PYH2_k127_2607483_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000005486 115.0
PYH2_k127_2654003_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 391.0
PYH2_k127_2654003_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000002574 57.0
PYH2_k127_2654003_2 - - - - 0.0007678 48.0
PYH2_k127_2693426_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000001472 226.0
PYH2_k127_2693426_1 vacuolar iron transporter - GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006828,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015075,GO:0015318,GO:0016020,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030026,GO:0031090,GO:0034220,GO:0034755,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055071,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071421,GO:0097577,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098805 - 0.00000000000000000000001098 109.0
PYH2_k127_2693426_2 Radical SAM K04069 - 1.97.1.4 0.000000000000004472 77.0
PYH2_k127_2868946_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000004237 260.0
PYH2_k127_2868946_1 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005567 251.0
PYH2_k127_2868946_2 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000005408 154.0
PYH2_k127_2868946_3 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000003118 121.0
PYH2_k127_2868946_4 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000006528 96.0
PYH2_k127_2868946_5 helix_turn_helix ASNC type K03719 - - 0.0000003936 62.0
PYH2_k127_2868946_6 ubiE/COQ5 methyltransferase family - - - 0.00001671 57.0
PYH2_k127_2876936_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 612.0
PYH2_k127_2876936_1 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008704 328.0
PYH2_k127_2876936_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000001488 250.0
PYH2_k127_2876936_3 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000002182 105.0
PYH2_k127_2876936_4 but it may be involved in stabilization of the trimeric complex - - - 0.00005057 53.0
PYH2_k127_2896591_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 315.0
PYH2_k127_2896591_1 Calcineurin-like phosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000007936 203.0
PYH2_k127_2896591_2 FG-GAP repeat - - - 0.0000000000000000000053 111.0
PYH2_k127_2896591_3 - K00960 - 2.7.7.6 0.0000000000000003431 79.0
PYH2_k127_2896591_4 Putative Ig domain - - - 0.0001561 56.0
PYH2_k127_2897823_0 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 301.0
PYH2_k127_2897823_1 archaeal coiled-coil protein - - - 0.000000000000000000000000007582 123.0
PYH2_k127_2897823_2 Amidohydrolase family K01468 - 3.5.2.7 0.000000000000000000002643 96.0
PYH2_k127_2897823_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0007807 45.0
PYH2_k127_2987672_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009056 619.0
PYH2_k127_2987672_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000403 273.0
PYH2_k127_2987672_2 Transport and Golgi organisation 2 - - - 0.000003354 55.0
PYH2_k127_3033911_0 Mechanosensitive ion channel - - - 0.000000000000000000002103 108.0
PYH2_k127_3033911_1 COG0531 Amino acid transporters - - - 0.0000000000000000002646 99.0
PYH2_k127_3072036_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002549 267.0
PYH2_k127_3072036_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000009249 244.0
PYH2_k127_3072036_2 Protein of unknown function (DUF1349) - - - 0.0000000000000000000000000000000000000000000000000000000000000001771 249.0
PYH2_k127_3072036_3 ZIP Zinc transporter K07238,K16267 - - 0.0000000000000004172 88.0
PYH2_k127_3072036_4 Transcriptional regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000278 81.0
PYH2_k127_3072036_5 protein conserved in archaea - - - 0.00000000000828 79.0
PYH2_k127_3095385_0 oxidoreductase subunit alpha K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 367.0
PYH2_k127_3095385_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 322.0
PYH2_k127_3095385_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00172 - 1.2.7.1 0.0000000000000000000000000001812 122.0
PYH2_k127_3110585_0 PFAM HhH-GPD family protein K07457 - - 0.0000000000000000000000000000000000000000000000000001151 204.0
PYH2_k127_3110585_1 HAD-hyrolase-like K01560 - 3.8.1.2 0.0000000000003305 77.0
PYH2_k127_3110585_2 Roadblock LC7 family protein K07131 - - 0.0000000000009715 73.0
PYH2_k127_3110585_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000003315 79.0
PYH2_k127_3122327_0 COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins K03113 - - 0.000000000000000000001853 98.0
PYH2_k127_3122327_1 Putative modulator of DNA gyrase K03568 - - 0.0000000000000002952 81.0
PYH2_k127_3122327_2 PFAM PKD domain - - - 0.0000000001087 74.0
PYH2_k127_3164004_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 444.0
PYH2_k127_3164004_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 413.0
PYH2_k127_3164004_10 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000002918 163.0
PYH2_k127_3164004_11 DnaB-like helicase C terminal domain K08482 - - 0.00000000000000000000000000000000007359 149.0
PYH2_k127_3164004_12 KaiC - - - 0.00000000000000000000000000000004201 136.0
PYH2_k127_3164004_13 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000001315 95.0
PYH2_k127_3164004_14 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000001548 76.0
PYH2_k127_3164004_15 COG0517 FOG CBS domain - - - 0.000000000005016 78.0
PYH2_k127_3164004_16 SCP-2 sterol transfer family - - - 0.000000001421 69.0
PYH2_k127_3164004_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 338.0
PYH2_k127_3164004_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 314.0
PYH2_k127_3164004_4 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 291.0
PYH2_k127_3164004_5 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000759 261.0
PYH2_k127_3164004_6 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.00000000000000000000000000000000000000000000000000000000000000001166 233.0
PYH2_k127_3164004_7 TatD related DNase K07049 - - 0.000000000000000000000000000000000000000000000000000000000000001488 229.0
PYH2_k127_3164004_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000001519 211.0
PYH2_k127_3164004_9 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000003941 202.0
PYH2_k127_3171551_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 7.984e-300 936.0
PYH2_k127_3171551_1 Protein conserved in bacteria K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000001193 255.0
PYH2_k127_3171551_2 PRC-barrel domain - - - 0.00000000000000000000000002844 110.0
PYH2_k127_3211161_0 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000003719 99.0
PYH2_k127_3211161_1 PFAM PKD domain containing protein - - - 0.00000006278 64.0
PYH2_k127_3223957_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006415 349.0
PYH2_k127_3223957_1 ATP-grasp domain K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007982 347.0
PYH2_k127_3223957_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000006563 254.0
PYH2_k127_3245288_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006828 319.0
PYH2_k127_3245288_1 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000001929 141.0
PYH2_k127_3245288_2 Winged helix DNA-binding domain - - - 0.0000000000000000001055 92.0
PYH2_k127_3272780_0 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 419.0
PYH2_k127_3272780_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 345.0
PYH2_k127_3272780_10 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.000000000371 71.0
PYH2_k127_3272780_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 344.0
PYH2_k127_3272780_3 PFAM UDP-N-acetylglucosamine 2-epimerase K01791 GO:0003674,GO:0003824,GO:0008761,GO:0016853,GO:0016854,GO:0016857 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002544 283.0
PYH2_k127_3272780_4 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000001825 228.0
PYH2_k127_3272780_5 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000001133 223.0
PYH2_k127_3272780_6 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000001325 192.0
PYH2_k127_3272780_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000002109 143.0
PYH2_k127_3272780_8 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000002976 114.0
PYH2_k127_3272780_9 rRNA binding K02944 - - 0.000000000006677 68.0
PYH2_k127_3309465_0 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K07575 - - 0.000000000000000000000000000000000000000000003354 174.0
PYH2_k127_3309465_1 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000004308 104.0
PYH2_k127_3309465_2 Tetratricopeptide TPR_2 repeat protein K06877 - - 0.000000000000000000001102 112.0
PYH2_k127_3335129_0 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000002099 211.0
PYH2_k127_3335129_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000008913 100.0
PYH2_k127_3335129_2 Circadian clock protein KaiC K06945 - - 0.00002712 53.0
PYH2_k127_334764_0 TIGRFAM oligopeptide dipeptide ABC transporter K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 472.0
PYH2_k127_334764_1 TIGRFAM oligopeptide dipeptide ABC transporter K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 356.0
PYH2_k127_334764_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 305.0
PYH2_k127_334764_3 PFAM metallophosphoesterase K06953 - - 0.000000003353 60.0
PYH2_k127_3361207_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000001172 157.0
PYH2_k127_3361207_1 Methionine biosynthesis protein MetW - - - 0.000000001581 70.0
PYH2_k127_3418185_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.761e-207 654.0
PYH2_k127_3418185_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 319.0
PYH2_k127_3418185_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000004415 249.0
PYH2_k127_3418185_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000008535 97.0
PYH2_k127_3418185_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000198 89.0
PYH2_k127_3418185_5 ATP synthase subunit C K02124 - - 0.0000008214 53.0
PYH2_k127_3446501_0 CoA binding domain K06929 - - 0.000000000000000000000000000000000000003306 151.0
PYH2_k127_3446501_1 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000002043 134.0
PYH2_k127_3449409_0 amine dehydrogenase activity - - - 0.000000000002701 81.0
PYH2_k127_3502703_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.425e-265 833.0
PYH2_k127_3502703_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.476e-243 777.0
PYH2_k127_3502703_2 COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 327.0
PYH2_k127_3502703_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000002477 106.0
PYH2_k127_3502703_4 peptidase dimerisation domain protein - - - 0.000000009088 59.0
PYH2_k127_354740_0 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K22441 - 2.3.1.57 0.0003702 53.0
PYH2_k127_3568991_0 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 351.0
PYH2_k127_3649665_0 OmpA family - - - 0.00000000003301 77.0
PYH2_k127_3649665_1 - - - - 0.000004406 57.0
PYH2_k127_3703918_0 Beta-Casp domain K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 460.0
PYH2_k127_3703918_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003467 238.0
PYH2_k127_3703918_10 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000121 64.0
PYH2_k127_3703918_2 Archaeal transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000000000000000000001144 229.0
PYH2_k127_3703918_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000002106 188.0
PYH2_k127_3703918_4 May be involved in maturation of the 30S ribosomal subunit K02966 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000000004749 188.0
PYH2_k127_3703918_5 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00311,K17830 - 1.3.1.101,1.3.7.11,1.5.5.1 0.000000000000000000000000000000000000000000011 168.0
PYH2_k127_3703918_6 Belongs to the PDCD5 family K06875 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000004257 102.0
PYH2_k127_3703918_7 Belongs to the ribosomal protein L31e family K02910 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000227 85.0
PYH2_k127_3703918_8 Protein of unknown function (DUF835) K01937,K02488 - 2.7.7.65,6.3.4.2 0.0000000000000008493 92.0
PYH2_k127_3703918_9 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.00000000001261 65.0
PYH2_k127_3717834_0 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000004431 203.0
PYH2_k127_3717834_1 Electron transfer flavoprotein K03522 - - 0.0000000000395 71.0
PYH2_k127_3730196_0 helicase superfamily c-terminal domain K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009422 426.0
PYH2_k127_3730196_1 Beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001877 267.0
PYH2_k127_3730196_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K05516 - - 0.0000000000000005566 83.0
PYH2_k127_3736703_0 Oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 304.0
PYH2_k127_3736703_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001096 273.0
PYH2_k127_3736703_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000002115 101.0
PYH2_k127_3736703_3 UDP binding domain K00012 - 1.1.1.22 0.0000000000001261 74.0
PYH2_k127_3753963_0 PFAM SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000003143 161.0
PYH2_k127_3753963_1 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000000000000001427 132.0
PYH2_k127_3753963_2 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000002999 95.0
PYH2_k127_3753963_3 Nitroreductase family - - - 0.000002238 51.0
PYH2_k127_3753963_4 - - - - 0.00001736 49.0
PYH2_k127_3754098_0 Nitrite and sulphite reductase 4Fe-4S - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 310.0
PYH2_k127_3754098_1 4Fe-4S dicluster domain K08264 - 1.8.98.1 0.000014 56.0
PYH2_k127_3754098_2 FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000014 56.0
PYH2_k127_3759708_0 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001114 276.0
PYH2_k127_3759708_1 PFAM peptidase M50 - - - 0.00000000000000000000000000000000005356 145.0
PYH2_k127_3759708_2 HELICc2 - - - 0.000000000000000000001089 111.0
PYH2_k127_3801231_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 443.0
PYH2_k127_3801231_1 Thiolase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008013 425.0
PYH2_k127_3801231_2 PFAM CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 326.0
PYH2_k127_3801231_3 AAA ATPase domain - - - 0.0000000000000000000000000000009884 142.0
PYH2_k127_3801231_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000008127 109.0
PYH2_k127_3801231_5 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0001525 47.0
PYH2_k127_3801231_6 AAA ATPase domain - - - 0.0005085 54.0
PYH2_k127_3801231_8 SCP-2 sterol transfer family - - - 0.0008164 48.0
PYH2_k127_3811021_0 TIGRFAM small GTP-binding protein K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 431.0
PYH2_k127_3811021_1 PFAM Aspartate glutamate uridylate kinase K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 311.0
PYH2_k127_3811021_2 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 307.0
PYH2_k127_3811021_3 VKc - - - 0.0000000000003004 76.0
PYH2_k127_3811021_4 Glutathione peroxidase K02199 - - 0.0000000000005342 78.0
PYH2_k127_3827791_0 deoxyribonuclease I activity K06131,K06915 - - 0.0000000000000000000000000000000000000000000000000006803 199.0
PYH2_k127_3827791_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000001141 138.0
PYH2_k127_3844906_0 NAD(P)-binding Rossmann-like domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1040.0
PYH2_k127_3844906_1 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 375.0
PYH2_k127_3844906_2 regulator of chromosome condensation, RCC1 - - - 0.0002358 53.0
PYH2_k127_3851089_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 522.0
PYH2_k127_3851089_1 Cysteinyl-tRNA synthetase K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 400.0
PYH2_k127_3851089_2 Belongs to the peptidase S8 family - GO:0005575,GO:0005623,GO:0031975,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009488 392.0
PYH2_k127_3851089_3 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006586 286.0
PYH2_k127_3851089_4 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000000000000000000000000000000000000000000004847 174.0
PYH2_k127_3851089_5 Belongs to the UPF0215 family K09120 - - 0.00000000000000000000000000000000000000003734 158.0
PYH2_k127_3851089_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.00000000000000000000000000000000000001373 148.0
PYH2_k127_3851089_7 Serine threonine protein kinase K02033 - - 0.00000000000000000000000006524 128.0
PYH2_k127_3851089_8 Belongs to the peptidase S8 family K01361,K08652 - 3.4.21.110,3.4.21.96 0.00000393 62.0
PYH2_k127_3851089_9 ADP-ribosylglycohydrolase - - - 0.0005002 48.0
PYH2_k127_3859220_0 Radical_SAM C-terminal domain K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.00000000000000000000000000000000000000000000004596 175.0
PYH2_k127_3859220_1 Rab subfamily of small GTPases K07874 GO:0000139,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005886,GO:0006810,GO:0006888,GO:0008092,GO:0008150,GO:0012505,GO:0016020,GO:0016192,GO:0017022,GO:0030742,GO:0031090,GO:0031984,GO:0032029,GO:0032036,GO:0032588,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048193,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0071944,GO:0080115,GO:0098588,GO:0098791 - 0.00000000000000000000000004125 119.0
PYH2_k127_3859220_2 Domain of unknown function DUF11 - - - 0.000000000000000000000001447 121.0
PYH2_k127_3859220_3 OmpA family - - - 0.00000000000000001967 91.0
PYH2_k127_3859220_4 OmpA family - - - 0.00000000002654 77.0
PYH2_k127_3873367_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 599.0
PYH2_k127_3873367_1 - - - - 0.00000000000000000000001213 103.0
PYH2_k127_3873367_2 PFAM Major Facilitator Superfamily - - - 0.00000000000006756 78.0
PYH2_k127_3873367_3 - - - - 0.0000000001178 68.0
PYH2_k127_3928556_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006759 400.0
PYH2_k127_3928556_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001175 267.0
PYH2_k127_3928556_2 Fic/DOC family - - - 0.00000000000000000000000000000000007923 145.0
PYH2_k127_3940334_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 487.0
PYH2_k127_3940334_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000002418 104.0
PYH2_k127_4018026_0 TIGRFAM CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.0000000000000000000000000000000000000000000000000000000000000000003952 241.0
PYH2_k127_4018026_1 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000001355 209.0
PYH2_k127_4018026_2 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000007248 158.0
PYH2_k127_4018026_3 COG3291 FOG PKD repeat - - - 0.0000003932 61.0
PYH2_k127_4018026_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.0001095 50.0
PYH2_k127_4024834_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K03387,K21567 - 1.18.1.2,1.19.1.1,1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000002008 254.0
PYH2_k127_4024834_1 - - - - 0.000000000000000000000000000000000000007059 150.0
PYH2_k127_4024834_2 DnaB-like helicase C terminal domain - - - 0.0000000000000000000000000000909 127.0
PYH2_k127_4024834_3 Pfam:DUF552 K09152 - - 0.0000000000000000000000001457 111.0
PYH2_k127_4172633_0 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000007486 74.0
PYH2_k127_4172633_1 DoxX K16937 - 1.8.5.2 0.0006078 51.0
PYH2_k127_4185609_0 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000001948 228.0
PYH2_k127_4185609_1 C-terminal, D2-small domain, of ClpB protein K03694 - - 0.00000000000000000000000000000000000000000000000000000000000000248 225.0
PYH2_k127_4185609_2 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.0000000000000000000000004765 117.0
PYH2_k127_421826_0 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 421.0
PYH2_k127_421826_1 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003029 279.0
PYH2_k127_421826_10 InterPro IPR011467 - - - 0.0000000085 65.0
PYH2_k127_421826_11 Short C-terminal domain K08982 - - 0.00000004434 59.0
PYH2_k127_421826_12 membrane-associated protein domain - - - 0.000001406 57.0
PYH2_k127_421826_13 40-residue YVTN family beta-propeller - - - 0.00001216 58.0
PYH2_k127_421826_14 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00002335 56.0
PYH2_k127_421826_2 Superoxide dismutase K00518 - 1.15.1.1 0.0000000000000000000000000000000000000000004069 163.0
PYH2_k127_421826_3 DGC domain - - - 0.0000000000000000000000000000000001536 142.0
PYH2_k127_421826_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000008765 132.0
PYH2_k127_421826_5 OsmC-like protein - - - 0.0000000000000000000000000000002589 129.0
PYH2_k127_421826_6 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.00000000000000000000000000001422 134.0
PYH2_k127_421826_7 DGC domain - - - 0.00000000000000000000000003207 114.0
PYH2_k127_421826_8 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.0000000000000003027 84.0
PYH2_k127_421826_9 redox-active disulfide protein 2 - - - 0.00000000000000041 82.0
PYH2_k127_4274172_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009334 259.0
PYH2_k127_4274172_1 B3/4 domain - - - 0.000000000000000000000000000000000000000000000000000000004924 209.0
PYH2_k127_4274172_2 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992,K19341 - - 0.0000000000000000000000000000000000000001245 170.0
PYH2_k127_428504_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 346.0
PYH2_k127_428504_1 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000003845 213.0
PYH2_k127_428504_2 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000003003 141.0
PYH2_k127_4321615_0 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 304.0
PYH2_k127_4321615_1 biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000001921 187.0
PYH2_k127_4321615_2 Ferric reductase NAD binding domain - - - 0.000000000000000000000000000000004857 135.0
PYH2_k127_4321615_3 Aldo/keto reductase family K00002 - 1.1.1.2 0.00000000000000000008351 90.0
PYH2_k127_4321615_4 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0000000000000000002375 100.0
PYH2_k127_4329497_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.225e-230 727.0
PYH2_k127_4329497_1 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000436 239.0
PYH2_k127_4329497_2 protein catabolic process K03420,K13525,K17681 - - 0.0000000000000000000000000000000000000000000000000001012 201.0
PYH2_k127_4329497_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000456 93.0
PYH2_k127_4329497_4 ABC-2 type transporter K01992 - - 0.000000000000000002539 95.0
PYH2_k127_435136_0 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.0000000000000000000000000000000000000001998 168.0
PYH2_k127_435136_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000001095 91.0
PYH2_k127_4502927_0 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 353.0
PYH2_k127_4502927_1 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 364.0
PYH2_k127_4502927_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005228 276.0
PYH2_k127_4502927_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000002309 241.0
PYH2_k127_4514700_0 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000000000000001318 211.0
PYH2_k127_4514700_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000001094 110.0
PYH2_k127_4514700_2 cheY-homologous receiver domain - - - 0.00000000000000000005496 96.0
PYH2_k127_4550908_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 397.0
PYH2_k127_4550908_1 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 366.0
PYH2_k127_4550908_2 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.0000000000000000007561 96.0
PYH2_k127_4574043_0 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 605.0
PYH2_k127_4574043_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 344.0
PYH2_k127_4574043_2 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 304.0
PYH2_k127_4574043_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000002846 243.0
PYH2_k127_4574043_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000005922 221.0
PYH2_k127_4574043_5 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000002456 162.0
PYH2_k127_4574043_6 FHA domain containing protein - - - 0.0000000001135 74.0
PYH2_k127_4578775_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 445.0
PYH2_k127_4578775_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 424.0
PYH2_k127_4578775_10 PFAM binding-protein-dependent transport systems inner membrane component K11070 - - 0.000000000000000000000000000000000001739 160.0
PYH2_k127_4578775_11 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000008726 147.0
PYH2_k127_4578775_12 - - - - 0.00000000000000000001406 93.0
PYH2_k127_4578775_13 Sulfite exporter TauE/SafE K07090 - - 0.0005155 46.0
PYH2_k127_4578775_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 431.0
PYH2_k127_4578775_3 Belongs to the ABC transporter superfamily K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 342.0
PYH2_k127_4578775_4 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 351.0
PYH2_k127_4578775_5 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000001762 230.0
PYH2_k127_4578775_6 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000001107 203.0
PYH2_k127_4578775_7 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000002045 191.0
PYH2_k127_4578775_8 Saccharopine dehydrogenase K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000001069 180.0
PYH2_k127_4578775_9 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.000000000000000000000000000000000000001158 170.0
PYH2_k127_4657245_0 protein conserved in archaea - - - 0.000000000000001006 86.0
PYH2_k127_4662599_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 406.0
PYH2_k127_4662599_1 Glycosyltransferase Family 4 - - - 0.0000000000007256 72.0
PYH2_k127_4662599_2 Belongs to the phosphohexose mutase family K03431 - 5.4.2.10 0.00000000001094 67.0
PYH2_k127_467354_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 528.0
PYH2_k127_469286_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 563.0
PYH2_k127_469286_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000005576 208.0
PYH2_k127_469286_2 lyase activity - - - 0.000000000000009943 88.0
PYH2_k127_469286_3 Belongs to the eukaryotic ribosomal protein eL33 family K02917 - - 0.0000192 55.0
PYH2_k127_4701736_0 von Willebrand factor, type A K07114 - - 0.000000000000000000000001217 120.0
PYH2_k127_4701736_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0001973 54.0
PYH2_k127_4718523_0 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 395.0
PYH2_k127_4718523_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000171 268.0
PYH2_k127_4718523_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000001317 248.0
PYH2_k127_4718523_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000005187 175.0
PYH2_k127_4718523_4 Transcriptional regulator K07332 - - 0.0000000000000000000001246 106.0
PYH2_k127_4718523_5 Transcriptional regulator PadR-like family - - - 0.00000000000000003388 90.0
PYH2_k127_4718523_6 aminopeptidase activity K19689 - - 0.0000002594 63.0
PYH2_k127_4718523_7 SCP-2 sterol transfer family - - - 0.00005685 54.0
PYH2_k127_4728615_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 451.0
PYH2_k127_4728615_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 330.0
PYH2_k127_4728615_2 Pfam:Methyltransf_26 K02493 - 2.1.1.297 0.0000000000000000000000001217 116.0
PYH2_k127_4728615_3 membrane protein (homolog of Drosophila rhomboid) - - - 0.0000000000000003909 88.0
PYH2_k127_4738205_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 543.0
PYH2_k127_4738205_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 516.0
PYH2_k127_4738205_2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 314.0
PYH2_k127_4738205_3 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000007068 222.0
PYH2_k127_4770815_0 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007805 331.0
PYH2_k127_4770815_1 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 345.0
PYH2_k127_4770815_2 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000003761 235.0
PYH2_k127_4770815_3 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000001127 222.0
PYH2_k127_4770815_4 PFAM Xylose isomerase domain protein TIM barrel K18910 - 5.1.3.30,5.1.3.31 0.0000000000000000003631 98.0
PYH2_k127_4770815_5 Possibly the antitoxin component of a - - - 0.000000004153 61.0
PYH2_k127_4805928_0 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 608.0
PYH2_k127_4805928_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 334.0
PYH2_k127_4805928_2 Sodium/calcium exchanger protein K07300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 320.0
PYH2_k127_4805928_3 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009957 284.0
PYH2_k127_4805928_4 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004195 267.0
PYH2_k127_4805928_5 Thiamine-binding protein - - - 0.000000000000000000000000001205 115.0
PYH2_k127_4805928_6 Peptidase family M54 K06974 - - 0.000000000000000000000001603 120.0
PYH2_k127_4805928_7 O-methyltransferase activity K03183,K15256 - 2.1.1.163,2.1.1.201 0.0000000000000001087 89.0
PYH2_k127_4805928_8 PFAM ABC-2 type transporter K01992 - - 0.000000000000006883 88.0
PYH2_k127_4805928_9 ABC-2 type transporter K01992 - - 0.000000000003814 77.0
PYH2_k127_4846234_0 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000009451 183.0
PYH2_k127_4846234_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.206 0.0000000000000000000000000000000000000001583 153.0
PYH2_k127_4846234_2 ParB-like nuclease domain - - - 0.0000000000000000000000002327 111.0
PYH2_k127_4846234_3 PRC-barrel domain - - - 0.00000000000000002249 88.0
PYH2_k127_4856830_0 Fungalysin metallopeptidase (M36) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 316.0
PYH2_k127_4856830_1 DEAD DEAH box helicase domain protein K03724 - - 0.0000000000000000000000000000000000001397 156.0
PYH2_k127_4894570_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 601.0
PYH2_k127_4894570_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 539.0
PYH2_k127_4894570_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000001111 103.0
PYH2_k127_4918020_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 485.0
PYH2_k127_4918020_1 ABC-type Fe3 transport system permease component K02053,K02054,K02063 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 427.0
PYH2_k127_4918020_2 ABC transporter K02010,K02017,K02052,K02062,K10112,K11072,K15497,K17240 - 3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000011 271.0
PYH2_k127_4918020_3 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000002319 219.0
PYH2_k127_4918020_4 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000004709 188.0
PYH2_k127_4918020_5 to orf3 of fosmid clone 4B7mr3 - - - 0.0000000000000000000000000000000000000000000000004078 191.0
PYH2_k127_4918020_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000004847 125.0
PYH2_k127_4918020_7 Transcriptional regulator K07108 - - 0.0000000001414 68.0
PYH2_k127_4922364_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 404.0
PYH2_k127_4922364_1 PFAM homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002056 286.0
PYH2_k127_4922364_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000001435 226.0
PYH2_k127_4922364_3 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000003945 115.0
PYH2_k127_494436_0 COG2366 Protein related to penicillin acylase K01434 - 3.5.1.11 0.000000000000000000000000000000000000001287 154.0
PYH2_k127_494436_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000002404 136.0
PYH2_k127_4963013_0 Peptidase family M3 K01392 - 3.4.24.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 604.0
PYH2_k127_4963013_1 Pfam:DUF650 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009363 483.0
PYH2_k127_4963013_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002146 254.0
PYH2_k127_4963013_3 ADP-ribose pyrophosphatase K03574 - 3.6.1.55 0.000000000000000000000000000725 130.0
PYH2_k127_4963013_4 PFAM regulatory protein, ArsR - - - 0.0000000000007249 77.0
PYH2_k127_4963013_5 PFAM Archaeal ATPase K03524,K06921 - 6.3.4.15 0.0000000002317 70.0
PYH2_k127_4964201_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000007221 226.0
PYH2_k127_4964201_1 - - - - 0.000000000000000000000000000000000000000000000002306 180.0
PYH2_k127_4964201_2 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family - - - 0.000002066 54.0
PYH2_k127_496603_0 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 316.0
PYH2_k127_496603_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008728 270.0
PYH2_k127_496603_2 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000007637 208.0
PYH2_k127_496603_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030880,GO:0031323,GO:0031326,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141 - 0.000000000000000000002795 94.0
PYH2_k127_502886_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 519.0
PYH2_k127_502886_1 Fibronectin type III domain - - - 0.000000000000000001089 100.0
PYH2_k127_502886_2 Esterase PHB depolymerase - - - 0.000002919 60.0
PYH2_k127_5048189_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000003233 248.0
PYH2_k127_5048189_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000000000000000000000006624 177.0
PYH2_k127_5048189_2 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000156 150.0
PYH2_k127_5048189_3 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.000000000002954 72.0
PYH2_k127_5067832_0 Asparaginase K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000004603 233.0
PYH2_k127_5067832_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000004237 223.0
PYH2_k127_5067832_2 protein conserved in archaea - - - 0.00000000000000000000001936 108.0
PYH2_k127_5067832_3 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000004835 104.0
PYH2_k127_5082323_0 cheY-homologous receiver domain - - - 0.000000000004112 77.0
PYH2_k127_5082323_1 peptidoglycan-associated (lipo)protein - - - 0.000006847 58.0
PYH2_k127_5082970_0 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000001021 241.0
PYH2_k127_5082970_1 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000000000000000000000000000000000000000001443 211.0
PYH2_k127_5095529_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 464.0
PYH2_k127_5095529_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002057 282.0
PYH2_k127_5095529_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.000000259 55.0
PYH2_k127_5095529_3 FR47-like protein - - - 0.00000806 57.0
PYH2_k127_5095529_4 Squalene phytoene synthase K00801 - 2.5.1.21 0.0009338 49.0
PYH2_k127_5132303_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 GO:0000502,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022623,GO:0022624,GO:0030163,GO:0032991,GO:0043170,GO:0043273,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 512.0
PYH2_k127_5132303_1 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000008298 111.0
PYH2_k127_5132303_2 - - - - 0.0003764 51.0
PYH2_k127_5142210_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 374.0
PYH2_k127_5142210_1 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 328.0
PYH2_k127_5142210_2 FAD binding domain K00313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 322.0
PYH2_k127_5142210_3 ferredoxin-like protein K03855 - - 0.0000000000000000000000004275 108.0
PYH2_k127_5192698_0 structural constituent of ribosome K02984 - - 0.00000000000000000000000000000000000000000000000000000000000282 215.0
PYH2_k127_5198363_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 544.0
PYH2_k127_5198363_1 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000148 267.0
PYH2_k127_5198363_2 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000001775 121.0
PYH2_k127_5198363_3 Binds to the 23S rRNA K02922 - - 0.0000000001803 62.0
PYH2_k127_5219681_0 Required for chromosome condensation and partitioning K03529 - - 1.167e-243 796.0
PYH2_k127_5219681_1 chromosome segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000007273 181.0
PYH2_k127_5219681_2 Segregation and condensation complex subunit ScpB K06024 - - 0.00000000000000000000000000000000009132 141.0
PYH2_k127_5219681_3 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000003037 119.0
PYH2_k127_5225461_0 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 447.0
PYH2_k127_5225461_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 306.0
PYH2_k127_5225461_2 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.260 0.00000000000000000000000000000000000000000000000000000001142 207.0
PYH2_k127_5225461_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000001387 111.0
PYH2_k127_5225461_4 Double zinc ribbon - - - 0.00000000001439 73.0
PYH2_k127_5233470_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 410.0
PYH2_k127_5262199_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000002542 249.0
PYH2_k127_5262199_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000001803 160.0
PYH2_k127_5263434_0 DnaB-like helicase C terminal domain K08482 - - 0.0000000000901 71.0
PYH2_k127_5267858_0 Toprim domain K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 359.0
PYH2_k127_5267858_1 metal ion binding - - - 0.00000000000000000005397 100.0
PYH2_k127_5267858_2 Belongs to the UPF0235 family K09131 - - 0.00000000001074 70.0
PYH2_k127_5283747_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 352.0
PYH2_k127_5304448_0 NAD FAD dependent dehydrogenase K12164 - - 0.0000000000000000000000000000000000000000000000001284 193.0
PYH2_k127_5304448_1 UFM1 transferase activity K12165 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0031624,GO:0032446,GO:0033554,GO:0034976,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044390,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070647,GO:0071568,GO:0071569,GO:0071704,GO:0140096,GO:1901564,GO:1990564,GO:1990592 - 0.00003176 53.0
PYH2_k127_5315158_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.395e-258 816.0
PYH2_k127_5315158_1 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000001872 234.0
PYH2_k127_5316249_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007169 439.0
PYH2_k127_5316249_1 SMART Ras small GTPase, Ras type - - - 0.0000000000000000000000005305 117.0
PYH2_k127_5316249_2 formylmethanofuran dehydrogenase, subunit E - - - 0.00000000000001882 84.0
PYH2_k127_5316249_3 DnaB-like helicase C terminal domain - - - 0.0000000000001806 74.0
PYH2_k127_5316249_4 Pfam:Arch_ATPase - - - 0.0008797 51.0
PYH2_k127_5323668_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 309.0
PYH2_k127_5323668_1 DHHA1 domain K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001859 287.0
PYH2_k127_5323668_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000001758 226.0
PYH2_k127_5323668_3 Ribosomal S13/S15 N-terminal domain K02956 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000002074 178.0
PYH2_k127_5323668_4 Protein of unknown function (DUF835) K01937,K02488 - 2.7.7.65,6.3.4.2 0.000000000000000005201 91.0
PYH2_k127_5323668_5 NAD dependent epimerase dehydratase - GO:0003674,GO:0003824,GO:0004031,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016623,GO:0016903,GO:0042221,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:1990748 - 0.000000000001357 68.0
PYH2_k127_5324305_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 466.0
PYH2_k127_5324305_1 Cytidylyltransferase-like K00952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.1 0.000000000000000000000000000000000000000000000000000000101 200.0
PYH2_k127_5324305_2 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000001346 101.0
PYH2_k127_5328796_0 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000029 205.0
PYH2_k127_5328796_1 - - - - 0.00000000000000000000000000000000000000000000000004235 195.0
PYH2_k127_5328796_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.206 0.000000009926 67.0
PYH2_k127_5328796_3 OB-fold nucleic acid binding domain - - - 0.0003575 48.0
PYH2_k127_5330654_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 358.0
PYH2_k127_5368995_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 518.0
PYH2_k127_5368995_1 - - - - 0.000007882 59.0
PYH2_k127_5407171_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 550.0
PYH2_k127_5407171_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703,K16792 - 4.2.1.114,4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 459.0
PYH2_k127_5407171_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000008961 56.0
PYH2_k127_5407171_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 411.0
PYH2_k127_5407171_3 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009219 257.0
PYH2_k127_5407171_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000001354 246.0
PYH2_k127_5407171_5 Nucleotidyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000002292 206.0
PYH2_k127_5407171_6 UbiA prenyltransferase family K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000025 184.0
PYH2_k127_5407171_7 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000425 157.0
PYH2_k127_5407171_8 - - - - 0.0000000000000000003849 93.0
PYH2_k127_5407171_9 signal peptide processing K03100 - 3.4.21.89 0.0000002018 53.0
PYH2_k127_5423677_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000001824 210.0
PYH2_k127_5423677_1 Leucyl aminopeptidase (Aminopeptidase t) - - - 0.000000000004682 78.0
PYH2_k127_5423677_2 Cupin domain - - - 0.00000001654 61.0
PYH2_k127_5423677_3 sequence-specific DNA binding - - - 0.0000001764 57.0
PYH2_k127_5464722_0 Polyprenyl synthetase K02523,K13787 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000000000000000000000005395 208.0
PYH2_k127_5464722_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000004499 160.0
PYH2_k127_5478045_0 Helix-hairpin-helix motif K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005523 247.0
PYH2_k127_5478045_1 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000004606 156.0
PYH2_k127_5478045_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.25 0.00000000000000000000000000005056 121.0
PYH2_k127_5478045_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000002111 108.0
PYH2_k127_5478045_4 RNA polymerase K03051 - 2.7.7.6 0.00000000000000000002378 96.0
PYH2_k127_5479809_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 360.0
PYH2_k127_5479809_1 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000002103 184.0
PYH2_k127_5506913_0 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.00000000000000000000000000000000000000002429 160.0
PYH2_k127_5506913_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000004918 90.0
PYH2_k127_5506913_2 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.0000000001758 66.0
PYH2_k127_5506913_3 Glycosyl transferase family 41 - - - 0.00000293 54.0
PYH2_k127_5543293_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 420.0
PYH2_k127_5543293_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 348.0
PYH2_k127_5543293_10 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000001103 111.0
PYH2_k127_5543293_2 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003565 277.0
PYH2_k127_5543293_3 Ribosomal Proteins L2, C-terminal domain K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000008597 259.0
PYH2_k127_5543293_4 Forms part of the polypeptide exit tunnel K02930 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000006802 214.0
PYH2_k127_5543293_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000000003961 176.0
PYH2_k127_5543293_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000001745 139.0
PYH2_k127_5543293_7 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000000000005799 131.0
PYH2_k127_5543293_8 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000000000006676 132.0
PYH2_k127_5543293_9 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000000002562 124.0
PYH2_k127_5594571_0 Aminotransferase class-III K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 456.0
PYH2_k127_5594571_1 ABC transporter, ATP-binding protein K02028,K17076 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 311.0
PYH2_k127_5594571_2 amino acid ABC transporter K02029 - - 0.00000000000000000000000000000002403 137.0
PYH2_k127_5594571_3 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.000000000000000000000000001207 123.0
PYH2_k127_5594571_4 DNA topoisomerase type I activity K03169 - 5.99.1.2 0.0000000000003174 72.0
PYH2_k127_5594571_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000001142 66.0
PYH2_k127_5594571_6 Protein conserved in bacteria - - - 0.0000000003559 61.0
PYH2_k127_5612654_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044,K13798 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000001141 151.0
PYH2_k127_5612654_1 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000006993 118.0
PYH2_k127_5612654_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000005518 103.0
PYH2_k127_5612654_3 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000001176 79.0
PYH2_k127_5612654_4 Domain of unknown function (DUF1610) K07580 - - 0.0000000000003683 70.0
PYH2_k127_5612654_5 Lamin Tail Domain - - - 0.000002159 61.0
PYH2_k127_5618231_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 4.939e-231 722.0
PYH2_k127_5618231_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000005439 228.0
PYH2_k127_5618231_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.00000000000000000000000001732 111.0
PYH2_k127_5618231_3 Periplasmic or secreted lipoprotein - - - 0.000001099 55.0
PYH2_k127_5618231_4 Membrane - - - 0.000003458 59.0
PYH2_k127_5653673_0 KH, type 1, domain K07041 - - 2.278e-264 828.0
PYH2_k127_5653673_1 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 1.922e-226 713.0
PYH2_k127_5653673_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000004694 241.0
PYH2_k127_5653673_3 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000002622 86.0
PYH2_k127_5656458_0 SMART Integrin alpha beta-propellor repeat protein - - - 0.000000000000000000000000000000000002088 159.0
PYH2_k127_5699159_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 1.004e-197 634.0
PYH2_k127_5699159_1 Pfam:KaiC - - - 0.000000000000000000000000000000000000002824 149.0
PYH2_k127_5699159_2 Protein disulfide isomerase family A, member 5 K01829,K09583 GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010033,GO:0012505,GO:0015036,GO:0015037,GO:0016020,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0023052,GO:0030968,GO:0031974,GO:0031984,GO:0033554,GO:0034620,GO:0034976,GO:0035966,GO:0035967,GO:0036498,GO:0042175,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0070013,GO:0070887,GO:0071310,GO:0098827,GO:0140096 5.3.4.1 0.000000005518 64.0
PYH2_k127_5703623_0 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000001111 103.0
PYH2_k127_5703623_1 4Fe-4S dicluster domain - - - 0.000000000000001616 78.0
PYH2_k127_5703623_2 negative regulation of heat generation - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0019899,GO:0019902,GO:0019903,GO:0030346,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0060255,GO:0065007 - 0.000000002487 68.0
PYH2_k127_5715666_0 DEAD/H associated K03724 - - 0.0 1416.0
PYH2_k127_5715666_1 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 381.0
PYH2_k127_5719719_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000009402 206.0
PYH2_k127_5719719_1 saccharopine dehydrogenase activity K19064 - 1.4.1.18 0.0000000000000000000000005074 111.0
PYH2_k127_5719719_2 Protein phosphatase 2C K17500 - 3.1.3.16 0.00000000000000000004033 105.0
PYH2_k127_5719719_3 PFAM transcriptional regulator TrmB - - - 0.000000000002306 76.0
PYH2_k127_5737630_0 Leucyl aminopeptidase (Aminopeptidase T) K19689 - - 0.0000000000000003261 92.0
PYH2_k127_5737630_1 - - - - 0.0000001112 61.0
PYH2_k127_5737630_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.00009372 53.0
PYH2_k127_5762496_0 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 367.0
PYH2_k127_5762496_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000001835 266.0
PYH2_k127_5762496_2 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000001549 73.0
PYH2_k127_5762496_3 poly-hydroxybutyrate biosynthetic process - - - 0.0000008463 58.0
PYH2_k127_5769702_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 467.0
PYH2_k127_5769702_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000408 88.0
PYH2_k127_5769702_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000003398 79.0
PYH2_k127_5771493_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.0000000000000000000000000009823 121.0
PYH2_k127_5771493_1 VanZ like family - - - 0.00000000003727 70.0
PYH2_k127_5781480_0 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000006125 81.0
PYH2_k127_5852530_0 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 314.0
PYH2_k127_5852530_1 PFAM Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000001004 228.0
PYH2_k127_5852530_2 SMART Ras small GTPase, Ras type - - - 0.0000000000000000000000000002325 125.0
PYH2_k127_5852530_3 COG3209 Rhs family protein - - - 0.0000000000000003281 93.0
PYH2_k127_5852530_4 COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein K02557,K03286 - - 0.0003668 53.0
PYH2_k127_5852530_5 - - - - 0.0008813 49.0
PYH2_k127_5881192_0 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001086 261.0
PYH2_k127_5881192_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000008435 115.0
PYH2_k127_5883742_0 Malate/L-lactate dehydrogenase K00073 - 1.1.1.350 0.000000000000000000000000000000000000000000000000000000000000000000000001018 255.0
PYH2_k127_5883742_1 SMART Ras small GTPase, Ras type - - - 0.0000000000000000000000000000001177 135.0
PYH2_k127_5889862_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 454.0
PYH2_k127_5889862_1 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 368.0
PYH2_k127_5889862_3 RNA-binding protein of the translin family K07477 - - 0.000000000000000000000000000000000000000000000000004744 188.0
PYH2_k127_5889862_5 Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000004592 169.0
PYH2_k127_5959299_0 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 338.0
PYH2_k127_5959299_1 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000023 113.0
PYH2_k127_5959299_2 histone H2A-K13 ubiquitination K01338,K07157 - 3.4.21.53 0.00000000000000000001529 96.0
PYH2_k127_5959299_3 - - - - 0.00000000000003939 78.0
PYH2_k127_5997007_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 0.000000000000000000000000000000000000000000000000000000000000000000001091 242.0
PYH2_k127_5997007_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000001199 254.0
PYH2_k127_5997007_2 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000001039 235.0
PYH2_k127_5997007_3 6,7-dimethyl-8-ribityllumazine synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000003543 209.0
PYH2_k127_5997007_4 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.00000000000000000000000000000000000000002986 168.0
PYH2_k127_5997007_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000002887 76.0
PYH2_k127_6028795_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 443.0
PYH2_k127_6028795_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 436.0
PYH2_k127_6028795_2 Tetratricopeptide repeat - - - 0.00000000000000000006274 96.0
PYH2_k127_6028795_3 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.00002354 48.0
PYH2_k127_6060012_0 PFAM tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 435.0
PYH2_k127_6060012_1 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 360.0
PYH2_k127_6060012_2 FR47-like protein K03789 - 2.3.1.128 0.000000000001769 74.0
PYH2_k127_6060012_3 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.000000002553 63.0
PYH2_k127_6134920_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000006419 75.0
PYH2_k127_6134920_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000004771 70.0
PYH2_k127_6134920_2 PFAM SpoVT AbrB K07172 - - 0.0001075 47.0
PYH2_k127_6134920_3 Dodecin K09165 - - 0.00026 50.0
PYH2_k127_6153143_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 512.0
PYH2_k127_6153143_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000003643 78.0
PYH2_k127_6222193_0 Rad51 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 335.0
PYH2_k127_6222193_1 Aldolase/RraA K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000006054 230.0
PYH2_k127_6222193_2 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000004284 213.0
PYH2_k127_6222193_3 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000000000000000004471 190.0
PYH2_k127_6243222_0 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000008319 235.0
PYH2_k127_6243222_1 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000005793 162.0
PYH2_k127_6243222_2 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase - - - 0.000000000001313 81.0
PYH2_k127_6338502_0 1,7-bisphosphate phosphatase - - - 0.0000000000000000000000000000000000001133 158.0
PYH2_k127_6338502_1 aldehyde dehydrogenase (NAD) activity K00128 - 1.2.1.3 0.000000000039 66.0
PYH2_k127_6364490_0 Malic enzyme, NAD binding domain K00027,K00029 - 1.1.1.38,1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 569.0
PYH2_k127_6364490_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 484.0
PYH2_k127_6364490_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000001879 167.0
PYH2_k127_6364490_11 PFAM Thioredoxin K03671 - - 0.0000000000000000000000000000000006096 136.0
PYH2_k127_6364490_12 NADH ubiquinone oxidoreductase 27 kD subunit K00332,K22160 - 1.5.98.3,1.6.5.3 0.000000000000000000000000000005104 125.0
PYH2_k127_6364490_13 cheY-homologous receiver domain - - - 0.00000000000000000000000576 116.0
PYH2_k127_6364490_14 NADH ubiquinone oxidoreductase subunit 11 or 4L (Chain K) K00340 - 1.6.5.3 0.0000000000000000006668 95.0
PYH2_k127_6364490_15 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K22158 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016695,GO:0046995,GO:0051911,GO:0055114 1.5.98.3 0.00000000000001358 78.0
PYH2_k127_6364490_16 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339,K05578 - 1.6.5.3 0.00000000000007055 76.0
PYH2_k127_6364490_17 mttA/Hcf106 family K03116 - - 0.0000000000003948 75.0
PYH2_k127_6364490_18 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0004258 52.0
PYH2_k127_6364490_2 Belongs to the complex I 49 kDa subunit family K00333,K13378 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 372.0
PYH2_k127_6364490_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 366.0
PYH2_k127_6364490_4 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 366.0
PYH2_k127_6364490_5 Proton-conducting membrane transporter K22169 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 356.0
PYH2_k127_6364490_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 306.0
PYH2_k127_6364490_7 electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05572 GO:0006091,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000001319 256.0
PYH2_k127_6364490_8 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001607 243.0
PYH2_k127_6364490_9 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000001377 186.0
PYH2_k127_6377650_0 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001472 294.0
PYH2_k127_6377650_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000001399 143.0
PYH2_k127_6377650_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000007497 99.0
PYH2_k127_640373_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000002821 70.0
PYH2_k127_6435827_0 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 422.0
PYH2_k127_6435827_1 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000001661 226.0
PYH2_k127_6435827_2 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000006737 202.0
PYH2_k127_6435827_3 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000001885 144.0
PYH2_k127_6435827_4 4 iron, 4 sulfur cluster binding K00205,K02573 - - 0.000000000000000000000006005 115.0
PYH2_k127_6435827_5 - - - - 0.0000000000000000000002635 102.0
PYH2_k127_6435827_6 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.0000000000000002771 86.0
PYH2_k127_6435827_7 DNA alkylation repair enzyme - - - 0.000000000000902 78.0
PYH2_k127_6435827_8 - - - - 0.0005076 46.0
PYH2_k127_6435827_9 SnoaL-like polyketide cyclase K07255 - - 0.0006974 53.0
PYH2_k127_6468828_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001738 279.0
PYH2_k127_6468828_1 Peptidase family C25 K03546,K20074 - 3.1.3.16 0.00005173 54.0
PYH2_k127_651358_0 Belongs to the MCM family K10726 - - 4.924e-210 711.0
PYH2_k127_651358_1 - - - - 0.0000000000000000004816 92.0
PYH2_k127_651358_2 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000682 87.0
PYH2_k127_651358_3 NMD protein affecting ribosome stability and mRNA decay K07562 - - 0.0000002568 61.0
PYH2_k127_651358_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0003116 44.0
PYH2_k127_6587994_0 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000003825 217.0
PYH2_k127_6587994_1 PFAM Fasciclin domain - - - 0.0000000000000000000000000000000000000000000000004163 179.0
PYH2_k127_6587994_2 - - - - 0.000000000000000000000000000000000000000001803 160.0
PYH2_k127_6587994_3 - - - - 0.00000000000000334 81.0
PYH2_k127_6587994_4 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.0004845 45.0
PYH2_k127_6667959_0 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000005236 159.0
PYH2_k127_6667959_1 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000001265 78.0
PYH2_k127_6667959_2 Transport and Golgi organisation 2 - - - 0.0000000002884 63.0
PYH2_k127_6667959_3 ubiE/COQ5 methyltransferase family - - - 0.000001624 60.0
PYH2_k127_6667959_4 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0002177 44.0
PYH2_k127_6736555_0 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008271 559.0
PYH2_k127_6736555_1 PFAM Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 310.0
PYH2_k127_6736555_2 PFAM Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000006418 248.0
PYH2_k127_6736555_3 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000005934 191.0
PYH2_k127_6747802_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255,K01259 GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 446.0
PYH2_k127_6747802_1 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.0000000000000000000000000000000000000000000000003988 179.0
PYH2_k127_6747802_2 Psort location Cytoplasmic, score 8.96 K03653 - 4.2.99.18 0.0000000000000000000000000005048 132.0
PYH2_k127_6747802_3 Winged helix-turn-helix DNA-binding - - - 0.00000006296 64.0
PYH2_k127_6801117_0 PFAM Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 456.0
PYH2_k127_6801117_1 PFAM Circadian clock protein KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000001588 241.0
PYH2_k127_6801117_2 Pfam:KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000003733 226.0
PYH2_k127_6801117_3 DJ-1/PfpI family - - - 0.000000000000000000000000000001104 130.0
PYH2_k127_6884706_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.779e-296 922.0
PYH2_k127_6884706_1 acetyl-CoA hydrolase transferase - - - 2.315e-214 683.0
PYH2_k127_6884706_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 300.0
PYH2_k127_6884706_3 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008475 290.0
PYH2_k127_6884706_4 methyltransferase K13311,K13326,K21335 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983 2.1.1.234 0.00000000000000000000000000000000000000000000000000000000000003554 224.0
PYH2_k127_6884706_5 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.000000002715 58.0
PYH2_k127_6884706_6 Acetyltransferase (GNAT) domain - - - 0.0004568 49.0
PYH2_k127_6907300_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000002437 233.0
PYH2_k127_6907300_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000009834 201.0
PYH2_k127_6910345_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000006041 213.0
PYH2_k127_6910345_1 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000002294 136.0
PYH2_k127_697216_0 DEAD/H associated K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 444.0
PYH2_k127_697216_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 308.0
PYH2_k127_6975560_0 PFAM Beta propeller domain K14475 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 430.0
PYH2_k127_6975560_1 resolution of meiotic recombination intermediates - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 358.0
PYH2_k127_6975560_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000001033 133.0
PYH2_k127_6975560_3 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000001497 85.0
PYH2_k127_7045488_0 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002378 272.0
PYH2_k127_7045488_1 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004276 265.0
PYH2_k127_7045488_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000009772 97.0
PYH2_k127_7120898_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 301.0
PYH2_k127_7120898_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003159 284.0
PYH2_k127_7120898_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000004402 198.0
PYH2_k127_7124331_0 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000002973 233.0
PYH2_k127_7124331_1 K homology RNA-binding domain K06961 - - 0.00000000000000000000000000000000000000000000000006504 194.0
PYH2_k127_7124331_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000003121 158.0
PYH2_k127_7124331_3 - - - - 0.000000000499 73.0
PYH2_k127_7124331_4 PFAM PKD domain containing protein - - - 0.00000003567 64.0
PYH2_k127_7124331_5 Copper binding proteins, plastocyanin/azurin family - - - 0.000000998 58.0
PYH2_k127_7133136_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 451.0
PYH2_k127_7133136_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 413.0
PYH2_k127_7133136_2 - - - - 0.000000000000000000000000000000000000000000000000004342 188.0
PYH2_k127_7133136_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000003929 131.0
PYH2_k127_7133136_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.0000000000000000000000000000001036 131.0
PYH2_k127_7133136_5 PFAM PEGA domain - - - 0.00000000000000001175 97.0
PYH2_k127_7133136_6 peptidase M36 K01417 - - 0.00001115 58.0
PYH2_k127_7133136_7 Acetyltransferase (GNAT) domain - - - 0.0002447 53.0
PYH2_k127_7133136_8 Domain of unknown function, E. rectale Gene description (DUF3881) - - - 0.0009045 52.0
PYH2_k127_7134990_0 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000008612 155.0
PYH2_k127_7157160_0 - - - - 0.00000000000000000000003465 111.0
PYH2_k127_7157160_1 Aspartyl protease - - - 0.000000000000001068 83.0
PYH2_k127_7157160_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000002547 70.0
PYH2_k127_7232645_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 567.0
PYH2_k127_7232645_1 exo-alpha-(2->6)-sialidase activity - - - 0.0005208 49.0
PYH2_k127_7249111_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000001808 114.0
PYH2_k127_7249111_1 Beta-lactamase superfamily domain - - - 0.000000000006979 68.0
PYH2_k127_7265942_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007282 273.0
PYH2_k127_7265942_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000004505 209.0
PYH2_k127_7265942_2 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - 0.00000000000000000000000000005028 126.0
PYH2_k127_728079_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 379.0
PYH2_k127_728079_1 metal-sulfur cluster biosynthetic enzyme K02612,K04488 - - 0.0000000000000000000000000000000008743 133.0
PYH2_k127_728079_2 Methionine synthase II (cobalamin-independent) K00549 - 2.1.1.14 0.0000000000114 70.0
PYH2_k127_7292881_0 Regulatory protein Crp K07730 - - 0.0000000000000000000000000001531 121.0
PYH2_k127_7292881_1 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.0000000000002031 84.0
PYH2_k127_7292881_2 Domain of unknown function (DUF4430) - - - 0.0000005211 57.0
PYH2_k127_7303852_0 Tetratricopeptide repeat - - - 0.000000000000000000003627 108.0
PYH2_k127_7303852_1 PFAM Tetratricopeptide repeat - - - 0.00000000000000000005429 106.0
PYH2_k127_7304470_0 in RNase L inhibitor, RLI K06174 - - 0.000000000000000000000000000000000000000000000004731 180.0
PYH2_k127_7304470_1 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000001913 94.0
PYH2_k127_7304470_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000001214 92.0
PYH2_k127_7323463_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.623e-245 768.0
PYH2_k127_7323463_1 IgGFc binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006272 290.0
PYH2_k127_7323463_2 Bacterial regulatory helix-turn-helix protein, lysR family K03574 - 3.6.1.55 0.0000000000000000000000000000000000001161 149.0
PYH2_k127_7323463_3 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000001856 112.0
PYH2_k127_7355520_0 Heat shock 70 kDa protein K04043 - - 1.813e-230 725.0
PYH2_k127_7355520_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000003302 98.0
PYH2_k127_7399875_0 Nickel-dependent hydrogenase K14126 - 1.8.98.5 2.766e-232 726.0
PYH2_k127_7399875_1 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 454.0
PYH2_k127_7399875_2 Methyl-viologen-reducing hydrogenase, delta subunit K14127,K14128 - 1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000001895 200.0
PYH2_k127_7399875_3 Heterodisulfide reductase subunit A and related polyferredoxins K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000001467 176.0
PYH2_k127_7399875_4 Hydrogenase maturation protease - - - 0.0000000000000000000001353 108.0
PYH2_k127_7399875_5 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0001298 51.0
PYH2_k127_7409630_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000001335 239.0
PYH2_k127_7409630_1 transcription regulator activity - - - 0.00000000000000000000000000000000000000005486 156.0
PYH2_k127_7416161_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 586.0
PYH2_k127_7416161_1 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 451.0
PYH2_k127_7416161_2 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000001498 229.0
PYH2_k127_7416161_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000006733 200.0
PYH2_k127_7446030_0 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003697 271.0
PYH2_k127_7446030_1 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.000000000000000000000000000000000000000001798 164.0
PYH2_k127_7446030_2 PFAM ribosomal protein S8E K02995 GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.00000000000000000000000000000000000000006517 156.0
PYH2_k127_7446030_3 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000008204 141.0
PYH2_k127_7472751_0 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 370.0
PYH2_k127_7472751_1 COG0438 Glycosyltransferase K19002 - 2.4.1.337 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002399 278.0
PYH2_k127_7472751_2 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001754 264.0
PYH2_k127_7472751_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000002609 142.0
PYH2_k127_7472751_4 - - - - 0.0000000000000000000000000065 114.0
PYH2_k127_7499226_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 461.0
PYH2_k127_7499226_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K18105 GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.5 0.0000000005708 62.0
PYH2_k127_7513835_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006763 257.0
PYH2_k127_7513835_1 transport system, permease component K01992 - - 0.0000000000000000000000000000000000000002247 168.0
PYH2_k127_7513835_2 pfam nudix - - - 0.0000000000000001707 84.0
PYH2_k127_7612398_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 379.0
PYH2_k127_7612398_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000137 261.0
PYH2_k127_7612398_2 Amidohydrolase family K01485,K01487 - 3.5.4.1,3.5.4.3 0.00000000000000000000000000000000000000000000001505 181.0
PYH2_k127_7612398_3 domain, Protein - - - 0.0000000000000000000000000008307 132.0
PYH2_k127_7612398_4 OmpA family - - - 0.00000000002983 78.0
PYH2_k127_7612398_5 OmpA family - - - 0.000000007524 66.0
PYH2_k127_7660596_0 Protein kinase domain K08851,K15904 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234,2.7.11.1 0.0000000000000000000000000000000000000000000005886 173.0
PYH2_k127_7660596_1 DEAD_2 K10844 - 3.6.4.12 0.00000000000000000000000000000000000008349 151.0
PYH2_k127_7660596_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000008476 87.0
PYH2_k127_7660596_3 - - - - 0.000000000000004932 81.0
PYH2_k127_7688486_0 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 315.0
PYH2_k127_7688486_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000000000000000000000002728 228.0
PYH2_k127_7688486_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000002566 80.0
PYH2_k127_7736581_0 4Fe-4S single cluster domain K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 537.0
PYH2_k127_7736581_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 383.0
PYH2_k127_7736581_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K09759,K22503 - 6.1.1.12,6.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000002537 264.0
PYH2_k127_7736581_3 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000001733 78.0
PYH2_k127_7743764_0 aminopeptidase K01256 - 3.4.11.2 8.386e-200 649.0
PYH2_k127_7787537_0 Acetyltransferase (GNAT) domain - - - 0.0000000007867 67.0
PYH2_k127_7798839_0 Pyruvoyl-dependent arginine decarboxylase K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000001348 184.0
PYH2_k127_7798839_1 - - - - 0.0000000000005342 78.0
PYH2_k127_7798839_2 deoxyhypusine monooxygenase activity - - - 0.00000000001127 72.0
PYH2_k127_7798839_3 FR47-like protein K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.00006046 46.0
PYH2_k127_7820166_0 Belongs to the enoyl-CoA hydratase isomerase family K15016 - 1.1.1.35,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 559.0
PYH2_k127_7820166_1 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 342.0
PYH2_k127_7870084_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 407.0
PYH2_k127_7870084_1 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000001588 228.0
PYH2_k127_7876752_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 489.0
PYH2_k127_7876752_1 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 426.0
PYH2_k127_7876752_2 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000002533 186.0
PYH2_k127_7916430_0 PFAM Forkhead-associated protein - - - 0.00000000000000000000000000000000000000000000000000008957 209.0
PYH2_k127_7916430_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000001133 69.0
PYH2_k127_7925591_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 309.0
PYH2_k127_7925591_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008146 273.0
PYH2_k127_7925591_2 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000303 249.0
PYH2_k127_7925591_3 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000002933 106.0
PYH2_k127_7925591_4 Exonuclease - - - 0.0000000000000000000062 108.0
PYH2_k127_7925591_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.0000029 58.0
PYH2_k127_7954349_0 AAA domain - - - 0.0000000000000000000000004006 122.0
PYH2_k127_7973327_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 479.0
PYH2_k127_7973327_1 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 349.0
PYH2_k127_7973327_2 Hydrogenase maturation protease K08315 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.23.51 0.000000000000000000000000000000001874 136.0
PYH2_k127_7973327_3 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.000000000000000000000000000005205 123.0
PYH2_k127_7973327_4 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K00338 - 1.6.5.3 0.00000000000000000000000002323 117.0
PYH2_k127_7973327_5 SPFH domain-Band 7 family - - - 0.0008761 50.0
PYH2_k127_7994069_0 Uncharacterized protein family (UPF0051) K09014 - - 4.68e-249 776.0
PYH2_k127_7994069_1 ABC transporter K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 355.0
PYH2_k127_7999044_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 577.0
PYH2_k127_7999044_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 426.0
PYH2_k127_8043090_0 OmpA family - - - 0.000000000005366 81.0
PYH2_k127_8100789_0 Fumarase C C-terminus K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 544.0
PYH2_k127_8100789_1 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000004489 156.0
PYH2_k127_8100789_2 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000001055 104.0
PYH2_k127_8100789_3 cytochrome c biogenesis protein K06196 - - 0.00000000000000003633 94.0
PYH2_k127_8100789_4 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000007852 64.0
PYH2_k127_8100789_5 cell redox homeostasis K12057,K22278 - 3.5.1.104 0.0000001919 65.0
PYH2_k127_8100789_6 CARDB - - - 0.0009779 51.0
PYH2_k127_8120824_0 GyrI-like small molecule binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003024 226.0
PYH2_k127_8120824_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000002679 224.0
PYH2_k127_8134695_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 1.378e-316 989.0
PYH2_k127_8134695_1 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000000000000003135 78.0
PYH2_k127_8196518_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.318e-200 649.0
PYH2_k127_8196518_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000176 218.0
PYH2_k127_8196518_2 - - - - 0.00000000000000000000000000000000000000000000000001161 187.0
PYH2_k127_8216613_0 DNA polymerase type-B family K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 489.0
PYH2_k127_8227566_0 TPR Domain containing protein - - - 0.0000000000000000000000000000000001204 140.0
PYH2_k127_8227566_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000003067 127.0
PYH2_k127_8227566_2 protein conserved in archaea - - - 0.0000000000006328 83.0
PYH2_k127_8227566_3 TIGRFAM RHS repeat-associated core domain - - - 0.0000000008231 73.0
PYH2_k127_823298_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 413.0
PYH2_k127_823298_1 PFAM AIG2 family protein - - - 0.0000000005308 65.0
PYH2_k127_8239904_0 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 287.0
PYH2_k127_8239904_1 SMART Ras small GTPase, Ras type - - - 0.00000000000000000000000000000002534 134.0
PYH2_k127_8239904_2 Protein of unknown function (DUF1349) - - - 0.00006128 52.0
PYH2_k127_8239904_3 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - GO:0003674,GO:0003824,GO:0004145,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0043937,GO:0043939,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0065007 - 0.0001533 51.0
PYH2_k127_8269306_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000003656 192.0
PYH2_k127_8269306_1 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000001098 163.0
PYH2_k127_8269306_2 Signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000002261 148.0
PYH2_k127_8280280_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 451.0
PYH2_k127_8280280_1 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000001497 159.0
PYH2_k127_8299913_0 DnaB-like helicase C terminal domain - - - 0.0000000000000000000000000000003322 137.0
PYH2_k127_8299913_1 Protein of unknown function (DUF835) - - - 0.00000000000003782 84.0
PYH2_k127_8299913_2 Tetratricopeptide repeat - - - 0.0000001087 60.0
PYH2_k127_840206_0 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000001333 185.0
PYH2_k127_840206_1 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992,K19341 - - 0.0002475 54.0
PYH2_k127_841860_0 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 339.0
PYH2_k127_841860_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000001788 139.0
PYH2_k127_841860_2 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000004862 120.0
PYH2_k127_841860_3 PKD domain - - - 0.000000000000000000005342 109.0
PYH2_k127_841860_4 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000004706 100.0
PYH2_k127_841860_6 Domain of unknown function (DUF4082) - - - 0.00000000007022 77.0
PYH2_k127_841860_7 self proteolysis - - - 0.0000001701 64.0
PYH2_k127_8430755_0 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000002104 143.0
PYH2_k127_8443837_1 - - - - 0.0000000000000000000006154 98.0
PYH2_k127_8443837_3 Major facilitator Superfamily K07552,K19577 - - 0.0005125 49.0
PYH2_k127_8447900_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1061.0
PYH2_k127_8480057_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169,K00186 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008694 407.0
PYH2_k127_8480057_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 381.0
PYH2_k127_8480057_2 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000004249 195.0
PYH2_k127_8480057_3 PAC2 family K06869 - - 0.00000000000000000000000000000000000000002216 162.0
PYH2_k127_8480057_4 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity K00188 - 1.2.7.7 0.0000000000000000000000005648 111.0
PYH2_k127_8480057_5 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000000000000003029 96.0
PYH2_k127_8480057_6 PFAM DoxX family protein K16937 - 1.8.5.2 0.000000000000003067 83.0
PYH2_k127_8526530_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 454.0
PYH2_k127_8526530_1 DnaB-like helicase C terminal domain - - - 0.000000000000000000000000000000000000000000000000007038 189.0
PYH2_k127_8526530_2 N-terminal 7TM region of histidine kinase - - - 0.0000392 53.0
PYH2_k127_8566321_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652,K01620 - 2.3.1.29,2.3.1.47,4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 419.0
PYH2_k127_8566321_1 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 351.0
PYH2_k127_8566321_2 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 349.0
PYH2_k127_8566321_3 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000003736 180.0
PYH2_k127_8566321_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000001518 85.0
PYH2_k127_8609137_0 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 336.0
PYH2_k127_8609137_1 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000001454 264.0
PYH2_k127_8609137_2 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000000000000000000001355 209.0
PYH2_k127_8609137_3 Tetratricopeptide repeat - - - 0.00000000000000000000002857 106.0
PYH2_k127_8609137_4 DNA polymerase beta domain protein region - - - 0.000005084 54.0
PYH2_k127_863661_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 372.0
PYH2_k127_863661_1 GTP-binding protein K06943 - - 0.0000000000009162 72.0
PYH2_k127_863661_2 membrane - - - 0.00000000003807 70.0
PYH2_k127_863661_3 Protein conserved in bacteria K07192 - - 0.0004125 51.0
PYH2_k127_8666717_0 'glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 316.0
PYH2_k127_8666717_1 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000002311 158.0
PYH2_k127_8666717_2 SPFH domain-Band 7 family - - - 0.000000000000000472 81.0
PYH2_k127_8690550_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 308.0
PYH2_k127_8690550_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000006061 100.0
PYH2_k127_8714910_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.085e-320 995.0
PYH2_k127_8714910_1 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615 2.7.1.36 0.0000000000000000000000001765 109.0
PYH2_k127_8714910_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000211 100.0
PYH2_k127_8716887_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1045.0
PYH2_k127_8716887_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.346e-204 642.0
PYH2_k127_8716887_2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 431.0
PYH2_k127_8716887_3 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 415.0
PYH2_k127_8716887_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000001648 228.0
PYH2_k127_8716887_5 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000001149 175.0
PYH2_k127_8731767_0 metal-binding domain in RNase L inhibitor, RLI K06174 GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 375.0
PYH2_k127_8731767_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01464,K01465,K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.2,3.5.2.3,3.5.2.5 0.000000000000000000000000000000000000000000000000000000776 198.0
PYH2_k127_8731767_2 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000001098 164.0
PYH2_k127_8779142_0 Belongs to the CarB family K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 1.612e-259 813.0
PYH2_k127_8779142_1 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 368.0
PYH2_k127_8779142_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002021 284.0
PYH2_k127_8779142_3 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004234 263.0
PYH2_k127_8779142_4 RibD C-terminal domain K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.000000000000000000000000000000000000000000000000000000005471 213.0
PYH2_k127_8779142_5 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000004465 136.0
PYH2_k127_8779142_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000501 121.0
PYH2_k127_8779142_7 redox protein, regulator of disulfide bond formation K07397 - - 0.0000000000000000001155 102.0
PYH2_k127_8779142_8 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000001301 73.0
PYH2_k127_8783607_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 469.0
PYH2_k127_8783607_1 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 441.0
PYH2_k127_8783607_2 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000005241 179.0
PYH2_k127_8783607_3 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.00000000000000000000000000000000000000000000004745 173.0
PYH2_k127_8783607_4 Peptidase family M28 K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000006887 174.0
PYH2_k127_8783607_5 Aminotransferase - - - 0.0000000000000000000000000000000000000000234 177.0
PYH2_k127_8783607_6 COG0500 SAM-dependent methyltransferases - - - 0.00000000000000000000000000000000000007494 151.0
PYH2_k127_8783607_7 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000002877 88.0
PYH2_k127_8785023_0 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.000000000000000000000000000000000000000000000000000000001922 214.0
PYH2_k127_8785023_1 Dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000007595 162.0
PYH2_k127_8785023_2 Belongs to the LDH MDH superfamily. LDH family K00016 - 1.1.1.27 0.00000000000002776 77.0
PYH2_k127_8838386_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 473.0
PYH2_k127_8838386_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 420.0
PYH2_k127_8838386_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000004242 194.0
PYH2_k127_8838386_3 Transcription elongation factor Spt5 K02601 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000814 201.0
PYH2_k127_8838386_4 TIGRFAM protein translocase SEC61 complex gamma subunit K07342 - - 0.00000000000005779 75.0
PYH2_k127_8838386_5 Archaeal Type IV pilin, N-terminal - - - 0.0000003323 62.0
PYH2_k127_8848190_0 DeoC/LacD family aldolase K08321,K11645 GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.245,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 374.0
PYH2_k127_8848190_1 L-threonine 3-dehydrogenase - - - 0.00004346 49.0
PYH2_k127_8848190_2 - - - - 0.0003331 51.0
PYH2_k127_8850742_0 FAD dependent oxidoreductase K15736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
PYH2_k127_8850742_1 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000952 128.0
PYH2_k127_8867992_0 ATPase associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 410.0
PYH2_k127_8867992_1 Domain of unknown function (DUF4129) - - - 0.000000000003517 69.0
PYH2_k127_8973248_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 538.0
PYH2_k127_8973248_1 Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000005248 78.0
PYH2_k127_897498_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 446.0
PYH2_k127_897498_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000001252 125.0
PYH2_k127_897498_2 Peptidase family M50 - - - 0.0000000000000000000001455 106.0
PYH2_k127_897498_3 Belongs to the UPF0273 family - - - 0.000000000000001054 86.0
PYH2_k127_9041082_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 334.0
PYH2_k127_9041082_1 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000002805 203.0
PYH2_k127_9041082_2 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000003129 65.0
PYH2_k127_9192625_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005706 499.0
PYH2_k127_9192625_1 electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000152 282.0
PYH2_k127_9192625_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 0.00000000000000000000000000000000000000000000001394 183.0
PYH2_k127_9222861_0 PFAM Aldehyde dehydrogenase family K00128,K00130,K00151,K10217 - 1.2.1.3,1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 492.0
PYH2_k127_9222861_1 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.00000000003165 77.0
PYH2_k127_935559_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000007694 278.0
PYH2_k127_935559_1 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.00000000000000000000000000000000000000000000000000000000000000000001 239.0
PYH2_k127_935559_2 Protein of unknown function (DUF531) K09725 - - 0.000000000000000000000000000000000000000000000000004361 194.0
PYH2_k127_935559_3 Biotin-requiring enzyme - - - 0.00000000000000001032 90.0
PYH2_k127_935559_4 Protein-tyrosine phosphatase K14165 - 3.1.3.16,3.1.3.48 0.00000000000001761 83.0
PYH2_k127_935559_5 - - - - 0.00000005062 56.0
PYH2_k127_980302_0 Sodium/hydrogen exchanger family K03455 - - 0.000000000000000000000000000000000000000002563 177.0
PYH2_k127_980302_1 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter - - - 0.000000004202 59.0