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Overview

ID MAG03225
Name PYH3_bin.3
Sample SMP0075
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus Methanoregula
Species
Assembly information
Completeness (%) 51.51
Contamination (%) 0.0
GC content (%) 48.0
N50 (bp) 5,354
Genome size (bp) 865,862

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes985

Gene name Description KEGG GOs EC E-value Score Sequence
PYH3_k127_1048347_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1047.0
PYH3_k127_1048347_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 5.195e-277 854.0
PYH3_k127_1048347_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 4.18e-270 837.0
PYH3_k127_1048347_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 5.334e-205 643.0
PYH3_k127_1048347_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 436.0
PYH3_k127_1048347_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 338.0
PYH3_k127_1048347_6 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000000006694 179.0
PYH3_k127_1048347_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000004796 150.0
PYH3_k127_1048347_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000005871 106.0
PYH3_k127_1095126_0 DEAD DEAH box helicase K06877 - - 0.0 1187.0
PYH3_k127_1095126_1 PFAM SufBD protein K07033 - - 4.857e-206 644.0
PYH3_k127_1095126_2 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 480.0
PYH3_k127_1095126_3 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 381.0
PYH3_k127_1095126_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 314.0
PYH3_k127_1095126_5 Exonuclease K07502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 297.0
PYH3_k127_1095126_6 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003126 283.0
PYH3_k127_1095126_7 - - - - 0.000000000000000000000000000000000000000002495 158.0
PYH3_k127_1095126_8 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000000000000000000000026 115.0
PYH3_k127_111312_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 2.053e-231 719.0
PYH3_k127_111312_1 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 449.0
PYH3_k127_111312_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 329.0
PYH3_k127_111312_3 - - - - 0.0000000000000000000000000000000000000000000000000000000001749 210.0
PYH3_k127_1174991_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 456.0
PYH3_k127_1174991_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 303.0
PYH3_k127_1174991_2 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009016 267.0
PYH3_k127_1174991_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000002862 119.0
PYH3_k127_1174991_4 PFAM peptidylprolyl isomerase FKBP-type K01802 - 5.2.1.8 0.000000000000000000000000005361 117.0
PYH3_k127_1174991_5 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000005388 108.0
PYH3_k127_1174991_8 Rubrerythrin K19824 - - 0.0005037 51.0
PYH3_k127_1174991_9 PFAM UspA - - - 0.0006373 44.0
PYH3_k127_1263320_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 4e-208 653.0
PYH3_k127_1263320_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 468.0
PYH3_k127_1263320_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 367.0
PYH3_k127_1263320_3 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 371.0
PYH3_k127_1263320_4 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 322.0
PYH3_k127_1263320_5 PFAM Ferritin, Dps family protein - - - 0.000000000000000000000000000000000000005646 146.0
PYH3_k127_1279358_0 DEAD DEAH box helicase domain protein K10896 - - 0.0 1111.0
PYH3_k127_1279358_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.00000000000000000000000004887 108.0
PYH3_k127_1389367_0 methanogenesis marker protein 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 548.0
PYH3_k127_1389367_1 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 406.0
PYH3_k127_1389367_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 402.0
PYH3_k127_1389367_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 387.0
PYH3_k127_1389367_4 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009714 263.0
PYH3_k127_1389367_5 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000000002009 196.0
PYH3_k127_1389367_6 Archaeal Type IV pilin, N-terminal - - - 0.00000000000000000000000000002418 122.0
PYH3_k127_1443008_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 428.0
PYH3_k127_1443008_1 Phosphoesterase K07095 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002952 250.0
PYH3_k127_1443008_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000002711 227.0
PYH3_k127_1443008_3 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000000002361 111.0
PYH3_k127_1443008_4 Protein of unknown function (DUF2769) - - - 0.00000000000000002466 84.0
PYH3_k127_1501521_0 PFAM SufBD protein K07033 - - 4.43e-210 657.0
PYH3_k127_1501521_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 295.0
PYH3_k127_1501521_2 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002253 255.0
PYH3_k127_1622456_0 TIGRFAM UbiD family - - - 4.108e-216 676.0
PYH3_k127_1622456_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 519.0
PYH3_k127_1622456_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000001369 235.0
PYH3_k127_1751185_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 1.586e-236 742.0
PYH3_k127_1751185_1 Domain of unknown function (DUF333) K14475 - - 0.00000000000000000000001465 108.0
PYH3_k127_177422_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 1.496e-206 643.0
PYH3_k127_177422_1 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 348.0
PYH3_k127_177422_2 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 295.0
PYH3_k127_177422_3 RNA-binding protein involved in rRNA processing K07569 - - 0.0000000000000000000000000000000000002399 141.0
PYH3_k127_177422_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000000000000000343 136.0
PYH3_k127_1777071_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.0 998.0
PYH3_k127_1777071_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 2.156e-276 855.0
PYH3_k127_1777071_2 - K16785 - - 0.000000000000000000227 89.0
PYH3_k127_1777071_3 - - - - 0.00004633 46.0
PYH3_k127_1777979_0 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007061 471.0
PYH3_k127_1777979_1 UV-endonuclease UvdE K13281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 382.0
PYH3_k127_1777979_10 PFAM Rubrerythrin - - - 0.000000000000000000006638 92.0
PYH3_k127_1777979_11 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000008878 51.0
PYH3_k127_1777979_2 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 344.0
PYH3_k127_1777979_3 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 289.0
PYH3_k127_1777979_4 TIGRFAM methionine-R-sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000003905 229.0
PYH3_k127_1777979_5 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000001781 230.0
PYH3_k127_1777979_6 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000001578 232.0
PYH3_k127_1777979_7 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000005501 210.0
PYH3_k127_1777979_8 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000001843 177.0
PYH3_k127_1777979_9 DNA polymerase Ligase (LigD) K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000146 169.0
PYH3_k127_1919118_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1349.0
PYH3_k127_1919118_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 317.0
PYH3_k127_1919118_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 318.0
PYH3_k127_1919118_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 299.0
PYH3_k127_1919118_4 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 286.0
PYH3_k127_1919118_5 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000008671 246.0
PYH3_k127_1919118_6 TIGRFAM Small GTP-binding protein K06945 - - 0.000000000000000000000000000000000000000000000000000000000236 207.0
PYH3_k127_1919118_7 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000000004473 155.0
PYH3_k127_1923525_0 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 435.0
PYH3_k127_1923525_1 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000001379 165.0
PYH3_k127_1923525_2 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000001141 121.0
PYH3_k127_201647_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 4e-208 652.0
PYH3_k127_201647_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 368.0
PYH3_k127_201647_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000001104 248.0
PYH3_k127_201647_3 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000000000000000000000000000000000000000007416 166.0
PYH3_k127_201647_4 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000002526 64.0
PYH3_k127_2020664_0 COG0784 FOG CheY-like receiver K01584 - 4.1.1.19 0.0 1112.0
PYH3_k127_2020664_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009849 386.0
PYH3_k127_2020664_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000003983 179.0
PYH3_k127_2165689_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 583.0
PYH3_k127_2165689_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 544.0
PYH3_k127_2165689_2 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007469 391.0
PYH3_k127_2165689_3 - - - - 0.000000000000000000000000000000000000000000000000007357 185.0
PYH3_k127_2165689_4 - - - - 0.000002018 52.0
PYH3_k127_2309290_0 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 1.888e-212 668.0
PYH3_k127_2309290_1 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 1.845e-207 651.0
PYH3_k127_2309290_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009945 436.0
PYH3_k127_2309290_3 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 313.0
PYH3_k127_2309290_4 Thioredoxin - - - 0.000000000000000000000000000000000000000000005407 166.0
PYH3_k127_2309290_5 Protein of unknown function (DUF2769) - - - 0.000000000000000000000000007332 113.0
PYH3_k127_2339028_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 470.0
PYH3_k127_2339028_1 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 373.0
PYH3_k127_2375642_0 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 360.0
PYH3_k127_2375642_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 311.0
PYH3_k127_2375642_2 - - - - 0.00000000000000000000000000000000000003245 146.0
PYH3_k127_2375642_3 - - - - 0.00000000000000000000007678 100.0
PYH3_k127_2375642_4 PFAM aminotransferase class V - - - 0.000000000000000008685 85.0
PYH3_k127_2375642_5 Pfam:Pyridox_oxidase K07006 - - 0.0000000241 61.0
PYH3_k127_2407187_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 584.0
PYH3_k127_2407187_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.00000000000000000000000000000000000000000000000000000000000001701 218.0
PYH3_k127_2407187_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.0000001626 53.0
PYH3_k127_2473626_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 599.0
PYH3_k127_2473626_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 488.0
PYH3_k127_2473626_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 460.0
PYH3_k127_2473626_3 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 434.0
PYH3_k127_2473626_4 methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 404.0
PYH3_k127_2473626_5 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 393.0
PYH3_k127_2473626_6 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 327.0
PYH3_k127_2473626_7 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 326.0
PYH3_k127_2473626_8 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 320.0
PYH3_k127_2473626_9 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000008357 235.0
PYH3_k127_2527823_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 1.102e-248 773.0
PYH3_k127_2527823_1 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002953 274.0
PYH3_k127_2527823_2 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.0000000000000000000000000000000000000000000000000005834 197.0
PYH3_k127_2598378_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 3.165e-237 737.0
PYH3_k127_2598378_1 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 367.0
PYH3_k127_2598378_2 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000252 154.0
PYH3_k127_2598378_3 integral membrane protein - - - 0.00000000000000000000000000000000001301 143.0
PYH3_k127_2696459_0 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 496.0
PYH3_k127_2696459_1 Class III cytochrome C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 495.0
PYH3_k127_2696459_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 379.0
PYH3_k127_2696459_3 - - - - 0.00000000106 62.0
PYH3_k127_2696459_4 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000152 60.0
PYH3_k127_2717508_0 KH, type 1, domain K07041 - - 0.0 1226.0
PYH3_k127_2717508_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 321.0
PYH3_k127_2717508_2 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000004167 195.0
PYH3_k127_274732_0 TIGRFAM PAS sensor protein - - - 0.000000000000000000000000000000000000000000002094 169.0
PYH3_k127_274732_1 - - - - 0.0000000000000000003612 88.0
PYH3_k127_2820720_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.005e-200 629.0
PYH3_k127_2820720_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 454.0
PYH3_k127_2877064_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1323.0
PYH3_k127_2877064_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 391.0
PYH3_k127_2877064_2 major facilitator superfamily - - - 0.0000000000000000000000000002137 125.0
PYH3_k127_2885348_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 6.226e-275 854.0
PYH3_k127_2885348_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 507.0
PYH3_k127_2885348_2 - - - - 0.0000000001008 68.0
PYH3_k127_2900904_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 333.0
PYH3_k127_2900904_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
PYH3_k127_2900904_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000001143 145.0
PYH3_k127_3039344_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 1.056e-194 609.0
PYH3_k127_3039344_1 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 535.0
PYH3_k127_3039344_10 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002256 254.0
PYH3_k127_3039344_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001732 249.0
PYH3_k127_3039344_12 PFAM sigma-70 region 4 domain protein K09714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002298 248.0
PYH3_k127_3039344_13 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004931 241.0
PYH3_k127_3039344_14 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000000000000000000000000001656 210.0
PYH3_k127_3039344_15 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000000000000000000000000001492 188.0
PYH3_k127_3039344_16 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000000000000000000000000001371 151.0
PYH3_k127_3039344_17 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000000000001659 136.0
PYH3_k127_3039344_18 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000006318 115.0
PYH3_k127_3039344_19 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.000000000000000000000000001896 111.0
PYH3_k127_3039344_2 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 516.0
PYH3_k127_3039344_20 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000000000004633 105.0
PYH3_k127_3039344_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 454.0
PYH3_k127_3039344_4 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 436.0
PYH3_k127_3039344_5 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 423.0
PYH3_k127_3039344_6 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 421.0
PYH3_k127_3039344_7 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 415.0
PYH3_k127_3039344_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 296.0
PYH3_k127_3039344_9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008714 273.0
PYH3_k127_3151605_0 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008308 492.0
PYH3_k127_3151605_1 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 464.0
PYH3_k127_3151605_2 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 427.0
PYH3_k127_3151605_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001128 252.0
PYH3_k127_3151605_4 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000007395 204.0
PYH3_k127_3151605_5 but it may be involved in stabilization of the trimeric complex - - - 0.0000000000000000000001006 98.0
PYH3_k127_3366508_0 Neisseria PilC beta-propeller domain K02674 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 510.0
PYH3_k127_3366508_1 - - - - 0.00000000000000000000000000000000000000000000000000000004335 206.0
PYH3_k127_3366508_2 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000347 178.0
PYH3_k127_3366508_3 PKD domain containing protein K01337,K20276,K21449 - 3.4.21.50 0.00000000000000000000000000000000007417 156.0
PYH3_k127_3366508_4 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00000000001528 79.0
PYH3_k127_3383639_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 597.0
PYH3_k127_3383639_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 578.0
PYH3_k127_3383639_2 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 379.0
PYH3_k127_3383639_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000006396 253.0
PYH3_k127_3383639_4 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000001247 251.0
PYH3_k127_3383639_5 PFAM PRC-barrel domain - - - 0.00000000000000000000000000000000000005834 143.0
PYH3_k127_3383639_6 transcription factor (CBF NF-Y) - - - 0.00000000000000000000000000001822 118.0
PYH3_k127_3472326_0 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 322.0
PYH3_k127_3472326_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 297.0
PYH3_k127_3472326_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002796 276.0
PYH3_k127_3472326_3 small multi-drug export - - - 0.000000000000000000000000000000000001283 145.0
PYH3_k127_3479561_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0 1063.0
PYH3_k127_3479561_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 601.0
PYH3_k127_3495880_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.48e-317 974.0
PYH3_k127_3495880_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 2.656e-226 703.0
PYH3_k127_3495880_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 536.0
PYH3_k127_3495880_3 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 364.0
PYH3_k127_3495880_4 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 365.0
PYH3_k127_3495880_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 317.0
PYH3_k127_3495880_6 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000002322 242.0
PYH3_k127_3495880_7 TfuA-like protein - - - 0.00000000000000000000000000000000000000000000000007052 184.0
PYH3_k127_3495880_8 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000001092 148.0
PYH3_k127_3528246_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.867e-280 873.0
PYH3_k127_3528246_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 534.0
PYH3_k127_3528246_10 PspC domain K03973 - - 0.000000000000000001488 87.0
PYH3_k127_3528246_11 Archaeal Nre, N-terminal - - - 0.00001182 53.0
PYH3_k127_3528246_2 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 494.0
PYH3_k127_3528246_3 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 469.0
PYH3_k127_3528246_4 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 386.0
PYH3_k127_3528246_5 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 379.0
PYH3_k127_3528246_6 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000003198 217.0
PYH3_k127_3528246_7 Archaeal Nre, N-terminal - - - 0.00000000000000000000000000000000000000000000000000001499 192.0
PYH3_k127_3528246_8 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000007646 142.0
PYH3_k127_3528246_9 - - - - 0.00000000000000000000000000005777 118.0
PYH3_k127_3580717_0 Starch synthase catalytic domain - - - 8.293e-209 655.0
PYH3_k127_3580717_1 PFAM glycosyl transferase, group 1 - - - 4.016e-199 625.0
PYH3_k127_3580717_2 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 344.0
PYH3_k127_3920461_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1358.0
PYH3_k127_3920461_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.299e-204 656.0
PYH3_k127_3920461_2 PFAM aldo keto reductase K07079 - - 4.946e-194 613.0
PYH3_k127_3920461_3 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001992 252.0
PYH3_k127_3920461_4 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000001269 203.0
PYH3_k127_3924790_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 8.788e-231 732.0
PYH3_k127_3924790_1 - - - - 0.000000000000000000000000000002403 121.0
PYH3_k127_3924790_2 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000000000000000000000005648 120.0
PYH3_k127_3950805_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 3e-212 667.0
PYH3_k127_3950805_1 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 381.0
PYH3_k127_3950805_2 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000000002183 264.0
PYH3_k127_3950805_3 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000001223 209.0
PYH3_k127_3958443_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 6.003e-267 826.0
PYH3_k127_3958443_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 575.0
PYH3_k127_3958443_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 571.0
PYH3_k127_3958443_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 484.0
PYH3_k127_3958443_4 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 369.0
PYH3_k127_3958443_5 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000001973 232.0
PYH3_k127_4026146_0 - - - - 2.791e-195 612.0
PYH3_k127_4026146_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 589.0
PYH3_k127_4026146_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 567.0
PYH3_k127_4026146_3 Major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 530.0
PYH3_k127_4026146_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 481.0
PYH3_k127_4026146_5 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000000000000009308 207.0
PYH3_k127_4026146_6 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000005463 143.0
PYH3_k127_4026146_7 PFAM Rubrerythrin - - - 0.0000000000009374 68.0
PYH3_k127_4046369_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 0.0 1094.0
PYH3_k127_4046369_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 1.039e-224 700.0
PYH3_k127_4046369_10 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000000000000000000003669 133.0
PYH3_k127_4046369_12 PFAM PP-loop domain protein - - - 0.00000001569 56.0
PYH3_k127_4046369_13 4Fe-4S dicluster domain - - - 0.00000886 48.0
PYH3_k127_4046369_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 368.0
PYH3_k127_4046369_3 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 363.0
PYH3_k127_4046369_4 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 361.0
PYH3_k127_4046369_5 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006951 319.0
PYH3_k127_4046369_6 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003407 277.0
PYH3_k127_4046369_7 FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000000000000000000000000000000001765 212.0
PYH3_k127_4046369_8 Molybdopterin converting factor K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000002067 208.0
PYH3_k127_4046369_9 Transcriptional regulator K07108 - - 0.000000000000000000000000000000000000000006055 156.0
PYH3_k127_4066519_0 Ferrous iron transport B domain protein K04759 - - 3.149e-224 712.0
PYH3_k127_4066519_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000001198 254.0
PYH3_k127_4066519_2 Mn-dependent transcriptional regulator K03709 - - 0.00000000000000000000000000000000000000003914 159.0
PYH3_k127_411847_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 1.253e-209 658.0
PYH3_k127_411847_1 PBS lyase HEAT-like repeat - - - 0.000000000000000000000003515 107.0
PYH3_k127_416109_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.805e-274 849.0
PYH3_k127_416109_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 7.766e-207 648.0
PYH3_k127_416109_10 TIGRFAM acetate--CoA ligase K01895 - 6.2.1.1 0.000003476 48.0
PYH3_k127_416109_2 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 586.0
PYH3_k127_416109_3 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 508.0
PYH3_k127_416109_4 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 504.0
PYH3_k127_416109_5 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009897 419.0
PYH3_k127_416109_6 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 382.0
PYH3_k127_416109_7 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 376.0
PYH3_k127_416109_8 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001435 266.0
PYH3_k127_416109_9 protein conserved in archaea - - - 0.0000000000000000000000000000000000000000000000000002034 196.0
PYH3_k127_4194911_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 582.0
PYH3_k127_4194911_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 524.0
PYH3_k127_4194911_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 351.0
PYH3_k127_4194911_3 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000000000001129 216.0
PYH3_k127_4194911_4 - K06193 - - 0.0000000000002995 73.0
PYH3_k127_4205797_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 507.0
PYH3_k127_4205797_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 457.0
PYH3_k127_4205797_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.00000000000000000000000000000000004921 134.0
PYH3_k127_4205797_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000000000001594 106.0
PYH3_k127_4205797_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 299.0
PYH3_k127_4205797_3 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 295.0
PYH3_k127_4205797_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000321 271.0
PYH3_k127_4205797_5 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007781 258.0
PYH3_k127_4205797_6 Protein of unknown function (DUF1648) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006697 245.0
PYH3_k127_4205797_7 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000000000000003186 236.0
PYH3_k127_4205797_8 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000003884 231.0
PYH3_k127_4205797_9 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000000000000000000000000000000000000004113 214.0
PYH3_k127_4228932_0 ATP-grasp domain K06913 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 377.0
PYH3_k127_4228932_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 297.0
PYH3_k127_4228932_2 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009045 272.0
PYH3_k127_4228932_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.000000000000000000000000000000000000000000004745 169.0
PYH3_k127_4229270_0 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 373.0
PYH3_k127_4229270_1 - - - - 0.00000000000000000000000000000000000000000000000000005307 200.0
PYH3_k127_4229270_2 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000000002681 166.0
PYH3_k127_4229270_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000002195 153.0
PYH3_k127_4229270_4 - - - - 0.00000000000000000000000000000000000001814 149.0
PYH3_k127_4229270_5 - - - - 0.000000000000000000000000000000502 128.0
PYH3_k127_4229870_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1219.0
PYH3_k127_4229870_1 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 3.256e-215 674.0
PYH3_k127_4229870_2 Aldo/keto reductase family K07079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 526.0
PYH3_k127_4229870_3 Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor K00918 - 2.7.1.146,2.7.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 483.0
PYH3_k127_4229870_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 329.0
PYH3_k127_4229870_5 TIR domain - - - 0.0000000000000000007525 91.0
PYH3_k127_4251710_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1151.0
PYH3_k127_4251710_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1064.0
PYH3_k127_4251710_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.0 1014.0
PYH3_k127_4251710_3 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 364.0
PYH3_k127_4251710_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.000000000000000000000000000000000001227 139.0
PYH3_k127_4309315_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1102.0
PYH3_k127_4309315_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07652 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 323.0
PYH3_k127_4309315_2 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 313.0
PYH3_k127_4309315_4 PFAM response regulator receiver K11443 - - 0.0000000000000000000000000000000000000000000007775 169.0
PYH3_k127_4330565_0 - - - - 0.00000006157 55.0
PYH3_k127_4330565_1 Concanavalin A-like lectin/glucanases superfamily - - - 0.0000003616 62.0
PYH3_k127_4330565_2 PFAM ABC-2 type transporter K01992 - - 0.000005945 49.0
PYH3_k127_4330565_3 Methyltransferase domain - - - 0.000007923 49.0
PYH3_k127_4482636_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 - 1.12.98.1 4.954e-278 857.0
PYH3_k127_4482636_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 8.22e-197 616.0
PYH3_k127_4482636_2 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 566.0
PYH3_k127_4482636_3 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000887 518.0
PYH3_k127_4482636_4 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 478.0
PYH3_k127_4482636_5 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.000000000000000000000000000000000000000000000001503 179.0
PYH3_k127_4482636_6 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000001322 63.0
PYH3_k127_4482636_7 Flavodoxin - - - 0.0000006492 53.0
PYH3_k127_4482636_8 Flavodoxin - - - 0.00004116 48.0
PYH3_k127_4495362_0 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000001687 177.0
PYH3_k127_4495362_1 Phosphate-starvation-inducible E - - - 0.0000000000000000000000000000000000000000000106 166.0
PYH3_k127_4495362_2 HI0933 family K07007 - - 0.0000000000000000000000000000000000000002171 153.0
PYH3_k127_4495362_3 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000004415 75.0
PYH3_k127_4547470_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000001372 146.0
PYH3_k127_4547470_1 - - - - 0.0000000000000000000000000000000423 126.0
PYH3_k127_4547470_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000001269 100.0
PYH3_k127_4561239_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 5.281e-199 626.0
PYH3_k127_4561239_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008111 560.0
PYH3_k127_4561239_10 - - - - 0.00000000000000000000000000000000000001387 154.0
PYH3_k127_4561239_11 Dodecin K09165 - - 0.0000000000007236 71.0
PYH3_k127_4561239_12 metallopeptidase activity K01179,K20276 - 3.2.1.4 0.000000000451 67.0
PYH3_k127_4561239_2 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 415.0
PYH3_k127_4561239_3 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 323.0
PYH3_k127_4561239_4 META domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000743 279.0
PYH3_k127_4561239_5 PFAM Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001373 259.0
PYH3_k127_4561239_6 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000000000001172 234.0
PYH3_k127_4561239_7 AN1-like Zinc finger - - - 0.00000000000000000000000000000000000000000000000000000000000000008911 236.0
PYH3_k127_4561239_8 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000000000000000000004489 223.0
PYH3_k127_4561239_9 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.000000000000000000000000000000000000000000000000000000003915 205.0
PYH3_k127_4663404_0 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 429.0
PYH3_k127_4663404_1 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 290.0
PYH3_k127_4663404_2 TIGRFAM methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000828 250.0
PYH3_k127_4663404_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000001929 64.0
PYH3_k127_4674082_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 359.0
PYH3_k127_4674082_1 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 303.0
PYH3_k127_4674082_2 - - - - 0.00000000000000000000000000000000008913 134.0
PYH3_k127_4674082_3 PFAM thioesterase superfamily - - - 0.0000000000000000000000000003004 115.0
PYH3_k127_4684015_0 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 460.0
PYH3_k127_4684015_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 330.0
PYH3_k127_4684015_2 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000002094 254.0
PYH3_k127_4684015_3 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000002417 89.0
PYH3_k127_4688550_0 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 312.0
PYH3_k127_4688550_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 310.0
PYH3_k127_4688550_2 Domain of unknown function DUF123 - - - 0.000000000000000000000000000000000000000000000000000001311 194.0
PYH3_k127_4688550_3 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000007179 140.0
PYH3_k127_4827055_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1131.0
PYH3_k127_4827055_1 Helix-hairpin-helix domain K02347 - - 6.851e-211 669.0
PYH3_k127_4851586_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 600.0
PYH3_k127_4851586_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 542.0
PYH3_k127_4991498_0 Collagenase K08303 - - 1.297e-253 809.0
PYH3_k127_4991498_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 373.0
PYH3_k127_4991498_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 336.0
PYH3_k127_4991498_3 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000004 257.0
PYH3_k127_5035731_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 503.0
PYH3_k127_5035731_1 PFAM phosphatidate cytidylyltransferase - - - 0.00000000000000000000000000000000000000000000214 170.0
PYH3_k127_5035731_2 Iron-sulfur cluster-binding domain K06871 - - 0.00000004199 57.0
PYH3_k127_5099096_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 482.0
PYH3_k127_5099096_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 372.0
PYH3_k127_5116179_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 489.0
PYH3_k127_5116179_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 424.0
PYH3_k127_5116179_2 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 349.0
PYH3_k127_5116179_3 Pas domain - - - 0.00000000007885 66.0
PYH3_k127_5199159_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.67e-307 948.0
PYH3_k127_5199159_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 473.0
PYH3_k127_5199159_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 467.0
PYH3_k127_5199159_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 394.0
PYH3_k127_5199159_4 - - - - 0.00002639 50.0
PYH3_k127_5256416_0 Predicted membrane protein (DUF2070) K08979 - - 9.202e-250 779.0
PYH3_k127_5256416_1 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 501.0
PYH3_k127_5256416_2 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 322.0
PYH3_k127_5256416_3 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006898 250.0
PYH3_k127_5256416_4 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000000000000000000008285 196.0
PYH3_k127_5256416_5 Family of unknown function (DUF5350) - - - 0.00000000000000000000000000000000000000000008633 161.0
PYH3_k127_5256416_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.00000000000000000000001246 101.0
PYH3_k127_5309613_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1209.0
PYH3_k127_5309613_1 DEAD DEAH box helicase domain protein K03725 - - 1.756e-255 792.0
PYH3_k127_5309613_2 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 464.0
PYH3_k127_5309613_3 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000001449 156.0
PYH3_k127_5309613_4 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.00000000000000000000000000000003656 126.0
PYH3_k127_5309613_5 Phage plasmid primase, P4 K06919 - - 0.00000000000000000000000001355 113.0
PYH3_k127_5444208_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 6.172e-217 677.0
PYH3_k127_5444208_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004563 517.0
PYH3_k127_5444208_2 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 384.0
PYH3_k127_5444208_3 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 288.0
PYH3_k127_5444208_4 - - - - 0.000000000000000000000000000000000001696 140.0
PYH3_k127_5455505_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 4.353e-250 774.0
PYH3_k127_5455505_1 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 514.0
PYH3_k127_5455505_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000598 254.0
PYH3_k127_5455505_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000001461 181.0
PYH3_k127_5460466_0 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 358.0
PYH3_k127_5460466_1 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 341.0
PYH3_k127_5460466_2 - - - - 0.000000000000000000000000000000000000000000002093 168.0
PYH3_k127_5460466_3 - - - - 0.000000000000000000000000000000000000000005065 162.0
PYH3_k127_5460466_4 - - - - 0.000000000000000000001602 96.0
PYH3_k127_5460466_5 COG NOG14600 non supervised orthologous group - - - 0.000000000018 65.0
PYH3_k127_5460466_6 - - - - 0.0001997 51.0
PYH3_k127_5478161_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1198.0
PYH3_k127_5478161_1 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 498.0
PYH3_k127_5478161_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00000000000000000000000000000000000000000000000000000000000001037 219.0
PYH3_k127_5478161_3 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000002163 138.0
PYH3_k127_5478161_4 PFAM Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000005474 126.0
PYH3_k127_5478161_5 Ferredoxin K05337 - - 0.0000000000000000000000012 104.0
PYH3_k127_5505504_0 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 374.0
PYH3_k127_5505504_1 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 339.0
PYH3_k127_5505504_2 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000003738 192.0
PYH3_k127_5505504_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000000000000000000004983 178.0
PYH3_k127_5505504_4 Pas domain - - - 0.000000000000000000000000000000000000000000000001656 175.0
PYH3_k127_553559_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 1.158e-215 675.0
PYH3_k127_553559_1 Belongs to the UPF0218 family K09735 - - 0.0000000000000000000000000000000000000000000000000000000000000376 219.0
PYH3_k127_553559_2 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000000000000000000000006949 181.0
PYH3_k127_553559_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000000000000000000000003322 143.0
PYH3_k127_553559_4 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000000000000000815 114.0
PYH3_k127_553559_5 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000000000172 68.0
PYH3_k127_5548377_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1828.0
PYH3_k127_5548377_1 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 325.0
PYH3_k127_5548377_2 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000003952 122.0
PYH3_k127_559059_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 6.274e-270 838.0
PYH3_k127_559059_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000003513 249.0
PYH3_k127_5618002_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 9.249e-239 748.0
PYH3_k127_5618002_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000003132 246.0
PYH3_k127_5618002_2 Helix-turn-helix XRE-family like proteins - - - 0.0000000000002624 69.0
PYH3_k127_5650324_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1138.0
PYH3_k127_5650324_1 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009407 565.0
PYH3_k127_5650324_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 381.0
PYH3_k127_5650324_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 369.0
PYH3_k127_5650324_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 337.0
PYH3_k127_5650324_5 Oxidoreductase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001758 277.0
PYH3_k127_5650324_6 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000004003 87.0
PYH3_k127_5650324_7 Domain of unknown function (DUF4405) - - - 0.000000000000000006865 89.0
PYH3_k127_5650324_8 membrane - - - 0.0000000002908 70.0
PYH3_k127_5658499_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 3.503e-254 787.0
PYH3_k127_5658499_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 1.483e-227 711.0
PYH3_k127_5658499_10 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000000000000000005761 176.0
PYH3_k127_5658499_11 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.000000000000000000000000000000000000000000000106 168.0
PYH3_k127_5658499_12 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.00000000000000000000000000000000000000000005537 162.0
PYH3_k127_5658499_13 CRS1_YhbY K07574 - - 0.00000000000000000000000000005597 117.0
PYH3_k127_5658499_14 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000000000008116 105.0
PYH3_k127_5658499_15 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000009682 91.0
PYH3_k127_5658499_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 515.0
PYH3_k127_5658499_3 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 505.0
PYH3_k127_5658499_4 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 354.0
PYH3_k127_5658499_5 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 310.0
PYH3_k127_5658499_6 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 298.0
PYH3_k127_5658499_7 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005594 276.0
PYH3_k127_5658499_8 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000000000000000000000000000000000000000006632 250.0
PYH3_k127_5658499_9 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000000000000000000000000000000000000000000000000005737 224.0
PYH3_k127_5658857_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 5.225e-266 827.0
PYH3_k127_5658857_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009635 600.0
PYH3_k127_5658857_2 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 586.0
PYH3_k127_5658857_3 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 424.0
PYH3_k127_5658857_4 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 379.0
PYH3_k127_5658857_5 protein conserved in archaea K09723 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002982 267.0
PYH3_k127_5658857_6 Belongs to the UPF0179 family K09730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004267 242.0
PYH3_k127_5658857_7 metal-binding protein - - - 0.0000000000000000000000000000000000007334 140.0
PYH3_k127_5658857_8 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000004809 122.0
PYH3_k127_5658857_9 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000006116 115.0
PYH3_k127_5761325_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000003739 137.0
PYH3_k127_5761325_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000000000006057 133.0
PYH3_k127_5761325_2 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000002615 65.0
PYH3_k127_5809834_0 cheY-homologous receiver domain - - - 0.0000000000000000000000000001537 119.0
PYH3_k127_5809834_1 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.000000000000000000000006148 103.0
PYH3_k127_5809834_2 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.0000000000512 65.0
PYH3_k127_5809834_4 SPFH domain-Band 7 family - - - 0.0006041 51.0
PYH3_k127_5915836_0 Belongs to the glycosyl hydrolase 2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 418.0
PYH3_k127_5915836_1 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 287.0
PYH3_k127_5915836_2 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000002532 217.0
PYH3_k127_5915836_3 Flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000002277 207.0
PYH3_k127_5931400_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 388.0
PYH3_k127_5931400_1 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 357.0
PYH3_k127_5931400_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005671 296.0
PYH3_k127_5937140_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1089.0
PYH3_k127_5968571_0 Aminotransferase class-III K09251 - 2.6.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 546.0
PYH3_k127_5968571_1 Oxidoreductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 327.0
PYH3_k127_5968571_2 PFAM Uncharacterised protein family (UPF0104) K07027 - - 0.0000000000001261 82.0
PYH3_k127_5968571_3 radical SAM domain protein - - - 0.000001405 54.0
PYH3_k127_5979959_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 515.0
PYH3_k127_5979959_1 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 493.0
PYH3_k127_5979959_2 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 488.0
PYH3_k127_5979959_3 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 294.0
PYH3_k127_5979959_4 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000005311 229.0
PYH3_k127_5979959_5 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000008982 213.0
PYH3_k127_5979959_6 Protein of unknown function (DUF1722) - - - 0.00000000000002013 76.0
PYH3_k127_6017357_0 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 514.0
PYH3_k127_6017357_1 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 371.0
PYH3_k127_603974_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.119e-253 783.0
PYH3_k127_603974_1 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 3.703e-205 645.0
PYH3_k127_603974_2 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001255 258.0
PYH3_k127_603974_3 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001823 258.0
PYH3_k127_603974_4 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000549 246.0
PYH3_k127_603974_5 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000005986 148.0
PYH3_k127_6065_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 7.318e-292 900.0
PYH3_k127_6065_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.584e-225 702.0
PYH3_k127_6065_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000000000000000000000000023 186.0
PYH3_k127_6065_3 - - - - 0.00000000000000000000000002416 109.0
PYH3_k127_6109894_0 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 2.542e-227 709.0
PYH3_k127_6109894_1 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 541.0
PYH3_k127_6109894_2 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 373.0
PYH3_k127_6109894_3 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000002043 194.0
PYH3_k127_6112569_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 3.781e-265 821.0
PYH3_k127_6112569_1 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 384.0
PYH3_k127_6112569_10 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000000000000000000000001049 198.0
PYH3_k127_6112569_11 PFAM Ribosomal protein K02912 - - 0.0000000000000000002326 95.0
PYH3_k127_6112569_2 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 326.0
PYH3_k127_6112569_3 Integral membrane protein DUF106 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 304.0
PYH3_k127_6112569_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 301.0
PYH3_k127_6112569_5 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000355 286.0
PYH3_k127_6112569_6 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000341 284.0
PYH3_k127_6112569_7 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002311 266.0
PYH3_k127_6112569_8 binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007804 261.0
PYH3_k127_6112569_9 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000000000000000002648 231.0
PYH3_k127_6171113_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 2.804e-289 894.0
PYH3_k127_6171113_1 PFAM ribonuclease II K01147 - 3.1.13.1 1.033e-224 705.0
PYH3_k127_6171113_10 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 317.0
PYH3_k127_6171113_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 292.0
PYH3_k127_6171113_12 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000001621 220.0
PYH3_k127_6171113_13 transcription activator, effector binding - - - 0.000000000000000000000000000000000000000000000000000000001666 203.0
PYH3_k127_6171113_14 - - - - 0.0000000000000000000000000000000000000000000000000000001465 199.0
PYH3_k127_6171113_15 AhpC/TSA family K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000901 190.0
PYH3_k127_6171113_16 TIR domain - - - 0.000000000000000000000000000000000000000000004416 168.0
PYH3_k127_6171113_18 - K00960 - 2.7.7.6 0.0000000000000000000000000002064 117.0
PYH3_k127_6171113_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 604.0
PYH3_k127_6171113_3 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006805 485.0
PYH3_k127_6171113_4 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 379.0
PYH3_k127_6171113_5 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 372.0
PYH3_k127_6171113_6 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 368.0
PYH3_k127_6171113_7 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 360.0
PYH3_k127_6171113_8 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 342.0
PYH3_k127_6171113_9 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 338.0
PYH3_k127_6216394_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 547.0
PYH3_k127_6216394_1 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009878 405.0
PYH3_k127_6216394_2 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000002752 211.0
PYH3_k127_6216394_3 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000001977 180.0
PYH3_k127_6230225_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 595.0
PYH3_k127_6230225_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 585.0
PYH3_k127_6230225_10 COG1002 Type II restriction enzyme, methylase subunits - - - 0.00008661 46.0
PYH3_k127_6230225_2 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 533.0
PYH3_k127_6230225_3 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 523.0
PYH3_k127_6230225_4 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000069 519.0
PYH3_k127_6230225_5 Cysteine-rich small domain K08260 - 3.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 422.0
PYH3_k127_6230225_6 Anaerobic ribonucleoside-triphosphate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000006281 231.0
PYH3_k127_6230225_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000002526 226.0
PYH3_k127_6230225_8 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000000004335 114.0
PYH3_k127_6230225_9 - - - - 0.00000000000259 71.0
PYH3_k127_6259861_0 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 543.0
PYH3_k127_6259861_1 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 347.0
PYH3_k127_6259861_10 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.000000000000000000007518 97.0
PYH3_k127_6259861_11 NiFe -hydrogenase-3-type complex Eha, membrane protein EhaE K14096 - - 0.00000000000000000001535 94.0
PYH3_k127_6259861_12 Predicted membrane protein (DUF2108) K14095 - - 0.00000000000485 68.0
PYH3_k127_6259861_2 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002179 271.0
PYH3_k127_6259861_3 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008506 248.0
PYH3_k127_6259861_4 - K14093 - - 0.00000000000000000000000000000000000000000000000000000000000000000003296 235.0
PYH3_k127_6259861_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K14107 - - 0.0000000000000000000000000000000000000000000000000000000000000002676 225.0
PYH3_k127_6259861_6 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000008246 211.0
PYH3_k127_6259861_7 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.00000000000000000000000000000000000000000000000002279 184.0
PYH3_k127_6259861_8 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000005169 130.0
PYH3_k127_6259861_9 Predicted membrane protein (DUF2109) K14094 - - 0.000000000000000000000001606 104.0
PYH3_k127_627879_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001885 253.0
PYH3_k127_627879_1 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000000000000000000001243 197.0
PYH3_k127_627879_2 - - - - 0.000000000000000000000000000000000000000000000000000008071 194.0
PYH3_k127_627879_3 Voltage gated chloride channel - - - 0.0000000000000000000000000007724 127.0
PYH3_k127_627879_4 - - - - 0.0000000000000000000000009598 109.0
PYH3_k127_627879_5 - - - - 0.000000000000000000000003853 111.0
PYH3_k127_627879_6 PFAM ABC-2 type transporter K01992 - - 0.000000000003528 67.0
PYH3_k127_627879_7 PFAM ABC-2 type transporter K01992 - - 0.000001334 57.0
PYH3_k127_6357848_0 Involved in regulation of DNA replication K10725 - - 3.432e-257 796.0
PYH3_k127_6357848_1 PFAM Aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 577.0
PYH3_k127_6357848_2 PFAM regulatory protein AsnC Lrp family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 285.0
PYH3_k127_63726_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 1.7e-232 726.0
PYH3_k127_63726_1 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 5.019e-194 609.0
PYH3_k127_63726_2 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000002875 259.0
PYH3_k127_63726_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000007045 113.0
PYH3_k127_6409796_0 Belongs to the glutamate synthase family - - - 1.175e-294 908.0
PYH3_k127_6409796_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 7.943e-209 659.0
PYH3_k127_6409796_2 PFAM glutamine amidotransferase, class-II - - - 1.381e-197 619.0
PYH3_k127_6409796_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 492.0
PYH3_k127_6409796_4 PFAM glutamate synthase alpha subunit domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 399.0
PYH3_k127_6409796_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000003027 136.0
PYH3_k127_6409796_6 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000002164 100.0
PYH3_k127_6417730_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 2.981e-246 764.0
PYH3_k127_6417730_1 COG0306 Phosphate sulphate permeases K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 443.0
PYH3_k127_6417730_2 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 293.0
PYH3_k127_6417730_3 Helix-turn-helix domain protein K03627 - - 0.000000000000000000000000000000000000000000000000000000000000000005354 229.0
PYH3_k127_6417730_4 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000004777 63.0
PYH3_k127_6443884_0 PFAM AIR synthase related protein K07388 - - 1.009e-210 661.0
PYH3_k127_6443884_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 351.0
PYH3_k127_6481865_0 PFAM dihydropteroate synthase, DHPS - - - 3.068e-225 706.0
PYH3_k127_6481865_1 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 6.074e-206 644.0
PYH3_k127_6481865_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 383.0
PYH3_k127_6481865_3 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 284.0
PYH3_k127_6481865_4 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000004591 228.0
PYH3_k127_6481865_5 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000000000000005394 205.0
PYH3_k127_6481865_6 metal-dependent phosphoesterases (PHP family) - - - 0.000000000000000000000000000000000000000000002316 172.0
PYH3_k127_6481865_7 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000009127 164.0
PYH3_k127_6512624_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.264e-258 801.0
PYH3_k127_6512624_1 Stage II sporulation protein M K06384 - - 0.00000000000000000005934 90.0
PYH3_k127_6558434_0 Belongs to the glutamate synthase family - - - 4.991e-212 668.0
PYH3_k127_6558434_1 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 515.0
PYH3_k127_6558434_2 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000002269 130.0
PYH3_k127_6562660_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 2.135e-218 683.0
PYH3_k127_6562660_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000355 507.0
PYH3_k127_6562660_2 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 389.0
PYH3_k127_6562660_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009 287.0
PYH3_k127_6593243_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 1.427e-275 855.0
PYH3_k127_6593243_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.209e-250 782.0
PYH3_k127_6593243_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.653e-216 680.0
PYH3_k127_6593243_3 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 477.0
PYH3_k127_6593243_4 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000000000000000000000007125 237.0
PYH3_k127_6593243_5 Pfam:DUF552 K09152 - - 0.00000000000000000000000000004183 116.0
PYH3_k127_6679062_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 3.491e-214 673.0
PYH3_k127_6679062_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 557.0
PYH3_k127_6679062_2 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 495.0
PYH3_k127_6679062_3 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 390.0
PYH3_k127_6679062_4 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 353.0
PYH3_k127_6679062_5 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000006538 160.0
PYH3_k127_668275_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.774e-228 711.0
PYH3_k127_668275_1 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 2.104e-202 634.0
PYH3_k127_668275_2 PAS domain K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 376.0
PYH3_k127_668275_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000001628 218.0
PYH3_k127_668275_4 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000001035 190.0
PYH3_k127_668275_5 - - - - 0.0000000000000000000000000000000000000000000006791 169.0
PYH3_k127_6711624_0 PFAM CBS domain - - - 4.616e-281 868.0
PYH3_k127_6711624_1 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 374.0
PYH3_k127_6711624_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 300.0
PYH3_k127_6711624_3 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000002599 230.0
PYH3_k127_6711624_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000257 223.0
PYH3_k127_6711624_5 - - - - 0.00000000000000000000000000000000000000000004055 171.0
PYH3_k127_6711624_6 - - - - 0.00000000000000000000000000000000001363 139.0
PYH3_k127_6711624_7 ATP-grasp domain K06913 - - 0.00000000000000000000000000000021 124.0
PYH3_k127_6711624_8 - - - - 0.00000000000000000004994 92.0
PYH3_k127_6853349_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 5.018e-262 820.0
PYH3_k127_6853349_1 PFAM Aldehyde dehydrogenase - - - 1.825e-235 735.0
PYH3_k127_6853349_10 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009581 297.0
PYH3_k127_6853349_11 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000005007 185.0
PYH3_k127_6853349_12 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000000000000003659 156.0
PYH3_k127_6853349_13 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.000000000000000000000005691 102.0
PYH3_k127_6853349_14 - - - - 0.0000000000000009201 78.0
PYH3_k127_6853349_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 6.338e-212 661.0
PYH3_k127_6853349_3 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 610.0
PYH3_k127_6853349_4 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 460.0
PYH3_k127_6853349_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 458.0
PYH3_k127_6853349_6 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 407.0
PYH3_k127_6853349_7 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 390.0
PYH3_k127_6853349_8 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 362.0
PYH3_k127_6853349_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005153 298.0
PYH3_k127_6870256_0 PFAM ABC-1 domain protein K03688 - - 7.842e-271 842.0
PYH3_k127_6870256_1 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 590.0
PYH3_k127_6870256_10 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.00000000000000000000000000000000000000000000001938 175.0
PYH3_k127_6870256_11 WLM domain K07043 - - 0.00000000000000000000000000000000000000000000187 169.0
PYH3_k127_6870256_12 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000009743 164.0
PYH3_k127_6870256_13 WLM domain K07043 - - 0.000000002702 59.0
PYH3_k127_6870256_14 Acetyltransferase (GNAT) domain K03824 - - 0.00000000843 61.0
PYH3_k127_6870256_15 Protein of unknown function DUF45 K07043 - - 0.0000122 48.0
PYH3_k127_6870256_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 548.0
PYH3_k127_6870256_3 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 426.0
PYH3_k127_6870256_4 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 387.0
PYH3_k127_6870256_5 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 383.0
PYH3_k127_6870256_6 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 377.0
PYH3_k127_6870256_7 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009563 373.0
PYH3_k127_6870256_8 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 320.0
PYH3_k127_6870256_9 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 312.0
PYH3_k127_6949376_0 Transposase domain (DUF772) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 591.0
PYH3_k127_6949376_1 Predicted Permease Membrane Region K07085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008623 451.0
PYH3_k127_6961890_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 419.0
PYH3_k127_6961890_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 381.0
PYH3_k127_6961890_2 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001638 272.0
PYH3_k127_6961890_3 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000000000000000000007326 235.0
PYH3_k127_6961890_4 - - - - 0.0000000000000000000000000000000000000000000000000000005308 198.0
PYH3_k127_6961890_5 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000000000000000001716 155.0
PYH3_k127_6961890_6 Pas domain - - - 0.000000000005295 67.0
PYH3_k127_7082035_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1239.0
PYH3_k127_7082035_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 419.0
PYH3_k127_7082035_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 349.0
PYH3_k127_7082035_3 - - - - 0.0000000000000000000000000000000000000006556 156.0
PYH3_k127_7082035_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000007511 120.0
PYH3_k127_7082035_5 - - - - 0.00000000000001258 79.0
PYH3_k127_7172341_0 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 393.0
PYH3_k127_7172341_1 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 338.0
PYH3_k127_7172341_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 338.0
PYH3_k127_7172341_3 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000009342 184.0
PYH3_k127_7178576_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 491.0
PYH3_k127_7178576_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 471.0
PYH3_k127_7178576_2 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006981 317.0
PYH3_k127_7178576_3 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002413 282.0
PYH3_k127_7186726_0 PFAM Radical SAM domain protein K06871 - - 8.019e-206 644.0
PYH3_k127_7186726_1 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000004817 138.0
PYH3_k127_7242802_0 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 508.0
PYH3_k127_7242802_1 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 424.0
PYH3_k127_7277370_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1549.0
PYH3_k127_7277370_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001092 277.0
PYH3_k127_7277370_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000007859 229.0
PYH3_k127_7277370_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000003367 117.0
PYH3_k127_7377432_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 3.089e-257 799.0
PYH3_k127_7377432_1 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000000001783 222.0
PYH3_k127_7377432_2 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000004989 182.0
PYH3_k127_7377432_3 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.000000000000000000000000000000000000000000000007939 173.0
PYH3_k127_7377432_4 Hydrogenase maturation protease K08315 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.23.51 0.0000000000000000000000000000000000000000005687 163.0
PYH3_k127_7391714_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 604.0
PYH3_k127_7391714_1 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 429.0
PYH3_k127_7391714_2 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 403.0
PYH3_k127_7391714_3 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 343.0
PYH3_k127_7391714_4 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 291.0
PYH3_k127_7391714_5 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001104 261.0
PYH3_k127_7391714_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000000000000005858 181.0
PYH3_k127_7391714_7 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000001687 150.0
PYH3_k127_7402783_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 540.0
PYH3_k127_7402783_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008604 489.0
PYH3_k127_7402783_2 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 372.0
PYH3_k127_7402783_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 340.0
PYH3_k127_7402783_4 - - - - 0.00000000000000000000000000000000000000000000001328 173.0
PYH3_k127_7402783_5 - - - - 0.000000000000000000000001072 108.0
PYH3_k127_7430116_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0 1074.0
PYH3_k127_7430116_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 297.0
PYH3_k127_7430116_2 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000002125 192.0
PYH3_k127_7430116_3 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.00000000000000000000000000000000000000001522 160.0
PYH3_k127_7430116_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000004329 96.0
PYH3_k127_7430116_5 carbonic anhydrase K01673 - 4.2.1.1 0.0000000001928 68.0
PYH3_k127_7440003_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 8.279e-249 771.0
PYH3_k127_7440003_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 5.018e-242 754.0
PYH3_k127_7440003_10 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003146 248.0
PYH3_k127_7440003_11 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000003487 212.0
PYH3_k127_7440003_12 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000000000000000000000002964 177.0
PYH3_k127_7440003_13 PFAM PUA domain K07398 - - 0.0000000000000000001618 95.0
PYH3_k127_7440003_2 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 4.758e-214 673.0
PYH3_k127_7440003_3 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 545.0
PYH3_k127_7440003_4 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 499.0
PYH3_k127_7440003_5 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 462.0
PYH3_k127_7440003_6 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007233 423.0
PYH3_k127_7440003_7 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009654 412.0
PYH3_k127_7440003_8 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 312.0
PYH3_k127_7440003_9 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001291 274.0
PYH3_k127_7447_0 phosphoglycerate mutase K15635 - 5.4.2.12 8.654e-194 610.0
PYH3_k127_7447_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 516.0
PYH3_k127_7447_2 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 438.0
PYH3_k127_7447_3 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000003934 184.0
PYH3_k127_7447_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000001564 190.0
PYH3_k127_7583397_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 7.643e-207 646.0
PYH3_k127_7583397_1 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 517.0
PYH3_k127_7583397_10 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000031 102.0
PYH3_k127_7583397_2 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 504.0
PYH3_k127_7583397_3 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 449.0
PYH3_k127_7583397_4 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 290.0
PYH3_k127_7583397_5 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.000000000000000000000000000000000000000005605 157.0
PYH3_k127_7583397_6 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000000006469 149.0
PYH3_k127_7583397_7 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.00000000000000000000000000000000000212 143.0
PYH3_k127_7583397_8 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000201 117.0
PYH3_k127_7583397_9 - - - - 0.00000000000000000000000003265 117.0
PYH3_k127_7585380_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 458.0
PYH3_k127_7585380_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000006933 116.0
PYH3_k127_7585380_2 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000004276 110.0
PYH3_k127_7621918_0 Protein-export membrane protein SecD K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 480.0
PYH3_k127_7621918_1 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005575 394.0
PYH3_k127_7621918_2 Protein of unknown function (DUF2551) - - - 0.00000000000000000000000000000000000000000001953 163.0
PYH3_k127_7621918_3 - - - - 0.000000000000000000000000000000000005137 138.0
PYH3_k127_7621918_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000001407 83.0
PYH3_k127_7692065_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001929 228.0
PYH3_k127_7692065_1 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.00000000000000000000000000000000000000000000000000000001595 210.0
PYH3_k127_7692065_2 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000008789 203.0
PYH3_k127_7692065_3 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000003625 99.0
PYH3_k127_7692065_4 Protein of unknown function (DUF2769) - - - 0.00000000000007772 71.0
PYH3_k127_7779106_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 556.0
PYH3_k127_7779106_1 membrane-associated protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 313.0
PYH3_k127_7808387_0 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 573.0
PYH3_k127_7808387_1 methanogen marker protein 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 297.0
PYH3_k127_7808387_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000003135 148.0
PYH3_k127_7808387_3 transcription factor (CBF NF-Y) - - - 0.000000000000000000000000000001375 123.0
PYH3_k127_781659_0 nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000101 281.0
PYH3_k127_781659_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003121 248.0
PYH3_k127_781659_2 Small multi-drug export protein - - - 0.000000000000000000000000000000000000000004268 163.0
PYH3_k127_781659_3 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.00000000000000000000000001731 111.0
PYH3_k127_781659_4 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000002523 79.0
PYH3_k127_781659_5 Tetratricopeptide repeat - - - 0.0000000009916 68.0
PYH3_k127_781659_6 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000002313 58.0
PYH3_k127_7836891_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 8.024e-306 947.0
PYH3_k127_7836891_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007272 294.0
PYH3_k127_7862684_0 SMART Elongator protein 3 MiaB NifB - - - 2.407e-287 889.0
PYH3_k127_7862684_1 phosphoesterase RecJ domain protein - - - 1.316e-267 829.0
PYH3_k127_7862684_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 582.0
PYH3_k127_7862684_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 321.0
PYH3_k127_7862684_4 PFAM PRC-barrel domain - - - 0.000000000000000000000000000000000119 133.0
PYH3_k127_7862684_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000002855 108.0
PYH3_k127_7906841_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 602.0
PYH3_k127_7906841_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 530.0
PYH3_k127_7915351_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 1.968e-214 672.0
PYH3_k127_7915351_1 Glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 442.0
PYH3_k127_7915351_2 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 314.0
PYH3_k127_7915351_3 Glycosyl transferase, family 2 - - - 0.0000000002738 68.0
PYH3_k127_7938484_0 PFAM TrkA-N domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 540.0
PYH3_k127_7938484_1 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 339.0
PYH3_k127_7938484_2 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000144 266.0
PYH3_k127_7998099_0 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 366.0
PYH3_k127_7998099_1 Flavodoxin - - - 0.0000000000000000000000000000000000000000000141 167.0
PYH3_k127_7998099_2 - - - - 0.00000000000000000000000000000000000000003016 162.0
PYH3_k127_7998099_3 Alpha beta hydrolase superfamily K01563 - 3.8.1.5 0.0000000000000000000000000000000000002207 142.0
PYH3_k127_7998099_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.0000000000000000000000000000911 120.0
PYH3_k127_7998099_5 - - - - 0.00000000000001792 81.0
PYH3_k127_7998099_6 - - - - 0.0000000000005827 77.0
PYH3_k127_7998099_7 Alpha beta hydrolase K01563,K22318 - 3.8.1.5 0.000001929 56.0
PYH3_k127_8012486_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 2.383e-196 619.0
PYH3_k127_8012486_1 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 474.0
PYH3_k127_8012486_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 366.0
PYH3_k127_8012486_3 DEAD DEAH box helicase domain protein K03725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 361.0
PYH3_k127_8012486_4 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 344.0
PYH3_k127_8058434_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 364.0
PYH3_k127_8058434_1 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000002928 252.0
PYH3_k127_8058434_4 Small-conductance mechanosensitive channel K05802 - - 0.00000000003448 74.0
PYH3_k127_8058434_5 Kazal type serine protease inhibitors - - - 0.0000005412 60.0
PYH3_k127_8064675_0 Belongs to the TCP-1 chaperonin family K22447 - - 2.229e-208 653.0
PYH3_k127_8064675_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 335.0
PYH3_k127_8064675_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 326.0
PYH3_k127_8064675_3 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000000000000000000000000000000000000001339 209.0
PYH3_k127_8139029_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 497.0
PYH3_k127_8139029_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002155 256.0
PYH3_k127_8139029_2 - - - - 0.000000000000000000000000000000000000000000006884 164.0
PYH3_k127_8156124_0 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 1.478e-241 752.0
PYH3_k127_8156124_1 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 1.659e-222 700.0
PYH3_k127_8156124_2 CHAD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 294.0
PYH3_k127_8178779_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 3.314e-232 723.0
PYH3_k127_8178779_1 Belongs to the UPF0288 family - - - 8.473e-226 709.0
PYH3_k127_8178779_2 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 554.0
PYH3_k127_8178779_3 PFAM ABC transporter K00400 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 386.0
PYH3_k127_8178779_4 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003064 269.0
PYH3_k127_8178779_5 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007653 252.0
PYH3_k127_8178779_6 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004157 246.0
PYH3_k127_8178779_7 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000000000000000005252 161.0
PYH3_k127_8178779_8 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.000000000000000000000000000000000001006 140.0
PYH3_k127_8364167_0 PFAM multicopper oxidase type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008888 402.0
PYH3_k127_8364167_1 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000003854 224.0
PYH3_k127_8364167_2 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000003432 164.0
PYH3_k127_8364167_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000002622 121.0
PYH3_k127_8364167_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000001141 65.0
PYH3_k127_8449973_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 435.0
PYH3_k127_8449973_1 to Modification methylase in Methanococcus jannaschii (Q58392) and Methanobacterium thermoformicicum (P29568) K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 428.0
PYH3_k127_8449973_2 - - - - 0.000000000000000000000004493 104.0
PYH3_k127_8454578_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 525.0
PYH3_k127_8454578_1 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 336.0
PYH3_k127_8454578_2 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001605 271.0
PYH3_k127_8454578_3 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000002434 228.0
PYH3_k127_8454578_4 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000000001903 159.0
PYH3_k127_8460046_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 408.0
PYH3_k127_8460046_1 COG2226 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000000000000000000002929 129.0
PYH3_k127_8460046_2 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000001152 123.0
PYH3_k127_8460046_3 Suf system fes assembly protein K04488,K11717 - 2.8.1.7,4.4.1.16 0.00000000000002752 74.0
PYH3_k127_8460046_4 redox protein regulator of disulfide bond formation - - - 0.000000001181 61.0
PYH3_k127_847369_0 PBS lyase K22221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 584.0
PYH3_k127_847369_1 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 438.0
PYH3_k127_847369_2 - K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002695 280.0
PYH3_k127_847369_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000402 248.0
PYH3_k127_847369_4 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000003555 171.0
PYH3_k127_847369_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000004716 123.0
PYH3_k127_847369_6 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000000000009663 97.0
PYH3_k127_852686_0 Sulfate permease K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 422.0
PYH3_k127_852686_1 Protein of unknown function (DUF3795) - - - 0.00000000000000000000000000000003093 128.0
PYH3_k127_852686_2 - K02339 - 2.7.7.7 0.0000005735 60.0
PYH3_k127_8560384_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 7.959e-205 642.0
PYH3_k127_8560384_1 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 286.0
PYH3_k127_8560384_2 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.00000000000000000000000000000000000000000000000002318 183.0
PYH3_k127_8560384_3 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit K00343,K05568,K14115,K22169 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000002709 184.0
PYH3_k127_869223_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002273 230.0
PYH3_k127_869223_1 - - - - 0.00000000000000000000000000000000000000000000000000000000001 212.0
PYH3_k127_869223_2 Histidine kinase K00936 - 2.7.13.3 0.0000000000000000000000000000000000000171 154.0
PYH3_k127_869223_3 - - - - 0.0000000000000006538 79.0
PYH3_k127_869223_4 - - - - 0.000000000006809 69.0
PYH3_k127_8738557_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000007143 85.0
PYH3_k127_8738557_1 Putative DNA-binding domain - - - 0.000000000000001138 88.0
PYH3_k127_8738557_2 TIGRFAM PAS sensor protein - - - 0.00000000006014 73.0
PYH3_k127_8815419_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 1.357e-208 655.0
PYH3_k127_8815419_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007539 489.0
PYH3_k127_8815419_2 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000000000000000008954 132.0
PYH3_k127_8815419_3 Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000001517 99.0
PYH3_k127_8815419_4 Protein of unknown function (DUF2953) - - - 0.00000697 56.0
PYH3_k127_8925234_0 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 502.0
PYH3_k127_8925234_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 462.0
PYH3_k127_8925234_2 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002715 281.0
PYH3_k127_8925234_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002643 239.0
PYH3_k127_8925234_4 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000944 167.0
PYH3_k127_8925234_5 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000001526 95.0
PYH3_k127_8996082_0 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 364.0
PYH3_k127_8996082_1 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000002913 225.0
PYH3_k127_8996082_2 PFAM Amidohydrolase 2 K07045 - - 0.00000000000000000000000000000000000000000000000000000000000002817 226.0
PYH3_k127_8996082_3 Thioesterase superfamily K02614 - - 0.00000000000000000000000000000000000000003074 157.0
PYH3_k127_8996082_4 response regulator, receiver - - - 0.000000000000000000000000000005319 121.0
PYH3_k127_8996082_5 Protein of unknown function (DUF1059) - - - 0.00007574 48.0
PYH3_k127_9044179_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.768e-284 878.0
PYH3_k127_9044179_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000529 222.0
PYH3_k127_9044179_2 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000000000000000000005749 198.0
PYH3_k127_9044179_3 binds to the 23S rRNA K02921 - - 0.00000000000000000000000000000000000000000000000338 174.0
PYH3_k127_9044179_4 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000344 102.0
PYH3_k127_9044179_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0000000000000000000004162 96.0
PYH3_k127_9044462_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 8.93e-230 714.0
PYH3_k127_9044462_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 558.0
PYH3_k127_9044462_2 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 497.0
PYH3_k127_9044462_3 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 386.0
PYH3_k127_9044462_4 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 355.0
PYH3_k127_9044462_5 CoB--CoM heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000002299 262.0
PYH3_k127_9044462_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000000000007379 160.0
PYH3_k127_9044462_7 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000007523 154.0
PYH3_k127_9065135_0 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 590.0
PYH3_k127_9065135_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 487.0
PYH3_k127_9065135_2 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000002016 243.0
PYH3_k127_9065135_3 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000002345 221.0
PYH3_k127_9065135_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000001897 53.0
PYH3_k127_9129824_0 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 289.0
PYH3_k127_9129824_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001999 298.0
PYH3_k127_9129824_2 PFAM Beta propeller domain K14475 - - 0.0000000000000000000000000000000000001824 151.0
PYH3_k127_9129824_3 glucosylceramidase activity - - - 0.0000000000000000000000000000000003237 134.0
PYH3_k127_9141309_0 Helix-turn-helix domain protein K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 426.0
PYH3_k127_9141309_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007001 404.0
PYH3_k127_9141309_2 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 360.0
PYH3_k127_9141309_3 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 337.0
PYH3_k127_9141309_4 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001112 281.0
PYH3_k127_9141309_5 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000006361 48.0
PYH3_k127_9142772_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 6.033e-215 671.0
PYH3_k127_9142772_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005044 246.0
PYH3_k127_9142772_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000007859 229.0
PYH3_k127_9142772_3 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000000000000000000000000003467 214.0
PYH3_k127_9142772_4 TIR domain - - - 0.0000000000395 71.0
PYH3_k127_9146605_0 Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007767 252.0
PYH3_k127_9146605_1 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.0000000000000000000000000000000000000000000000426 177.0
PYH3_k127_9146605_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000000000000000000000000000004694 175.0
PYH3_k127_9146605_3 - - - - 0.0000000000000000000000000000000000001768 157.0
PYH3_k127_9146605_4 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07324,K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000000004528 132.0
PYH3_k127_9171655_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.755e-305 949.0
PYH3_k127_9178659_0 LOR SDH bifunctional enzyme conserved - - - 8.858e-221 691.0
PYH3_k127_9178659_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.403e-216 674.0
PYH3_k127_9178659_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 430.0
PYH3_k127_9178659_3 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 308.0
PYH3_k127_9178659_4 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000001373 195.0
PYH3_k127_9178659_5 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000000000006812 107.0
PYH3_k127_9243590_0 Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 353.0
PYH3_k127_9243590_1 Leucine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 325.0
PYH3_k127_9243590_2 COG2226 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006337 243.0
PYH3_k127_9450072_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 1.097e-214 672.0
PYH3_k127_9450072_1 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 329.0
PYH3_k127_9450072_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 299.0
PYH3_k127_9450072_3 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002731 267.0
PYH3_k127_9450072_4 PHP C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005793 233.0
PYH3_k127_9450072_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000007467 95.0
PYH3_k127_952629_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 6.935e-244 757.0
PYH3_k127_952629_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 516.0
PYH3_k127_952629_2 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 471.0
PYH3_k127_952629_3 PFAM major facilitator superfamily MFS_1 K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 349.0
PYH3_k127_952629_4 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 282.0
PYH3_k127_952629_5 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.00000000000000000000000000000000000000000000000000000003651 201.0
PYH3_k127_9698874_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 1.178e-223 697.0
PYH3_k127_9698874_1 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 505.0
PYH3_k127_9698874_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000001824 225.0
PYH3_k127_9711354_0 Protein of unknown function (DUF460) K09150 - - 0.0 1009.0
PYH3_k127_9711354_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 443.0
PYH3_k127_9711354_2 Glycosyltransferase 28 domain - - - 0.00000000000000000000000000000001282 127.0
PYH3_k127_9711354_3 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000004317 79.0
PYH3_k127_9737709_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.425e-230 737.0
PYH3_k127_9737709_1 NADH:flavin oxidoreductase / NADH oxidase family K10680 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 525.0
PYH3_k127_9737709_2 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 347.0
PYH3_k127_9737709_3 LUD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001495 236.0
PYH3_k127_9737709_4 Rieske [2Fe-2S] domain - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005783,GO:0005829,GO:0006915,GO:0008150,GO:0008219,GO:0009987,GO:0012501,GO:0012505,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0097194 - 0.000000000000000005189 87.0
PYH3_k127_9737709_5 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.0002916 46.0
PYH3_k127_9737709_6 Protein of unknown function (DUF1059) - - - 0.0009014 46.0