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Overview

ID MAG03251
Name PYH3_bin.65
Sample SMP0075
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species
Assembly information
Completeness (%) 96.93
Contamination (%) 0.04
GC content (%) 55.0
N50 (bp) 39,314
Genome size (bp) 1,543,036

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1619

Gene name Description KEGG GOs EC E-value Score Sequence
PYH3_k127_1336388_0 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 584.0
PYH3_k127_1336388_1 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 352.0
PYH3_k127_1336388_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001614 284.0
PYH3_k127_1336388_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002742 239.0
PYH3_k127_1336388_4 - - - - 0.00000000000000000000000000000000000000000000000000004232 202.0
PYH3_k127_1336388_5 - - - - 0.0000000000000000000000000000000000000000000000000001462 200.0
PYH3_k127_1336388_7 - - - - 0.0000000000000000000003465 104.0
PYH3_k127_1471678_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1051.0
PYH3_k127_1471678_1 DEAD DEAH box helicase domain protein K03725 - - 3.754e-285 890.0
PYH3_k127_1471678_10 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 574.0
PYH3_k127_1471678_11 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 558.0
PYH3_k127_1471678_12 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 534.0
PYH3_k127_1471678_13 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 524.0
PYH3_k127_1471678_14 N-4 methylation of cytosine K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 525.0
PYH3_k127_1471678_15 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 500.0
PYH3_k127_1471678_16 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 464.0
PYH3_k127_1471678_17 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 453.0
PYH3_k127_1471678_18 by modhmm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007047 486.0
PYH3_k127_1471678_19 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 439.0
PYH3_k127_1471678_2 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.915e-250 781.0
PYH3_k127_1471678_20 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 423.0
PYH3_k127_1471678_21 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 420.0
PYH3_k127_1471678_22 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 396.0
PYH3_k127_1471678_23 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 365.0
PYH3_k127_1471678_24 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004873 356.0
PYH3_k127_1471678_25 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 356.0
PYH3_k127_1471678_26 TIGRFAM acetate--CoA ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 341.0
PYH3_k127_1471678_27 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 324.0
PYH3_k127_1471678_28 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 313.0
PYH3_k127_1471678_29 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 306.0
PYH3_k127_1471678_3 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 3.96e-245 767.0
PYH3_k127_1471678_30 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 291.0
PYH3_k127_1471678_31 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
PYH3_k127_1471678_32 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007001 280.0
PYH3_k127_1471678_33 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003067 251.0
PYH3_k127_1471678_34 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001232 243.0
PYH3_k127_1471678_35 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000000000003228 234.0
PYH3_k127_1471678_36 ZPR1-related zinc finger protein K06874 - - 0.0000000000000000000000000000000000000000000000000000000000000000583 226.0
PYH3_k127_1471678_37 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000002454 221.0
PYH3_k127_1471678_38 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN - - - 0.000000000000000000000000000000000000000000000000000000000128 209.0
PYH3_k127_1471678_39 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000004715 205.0
PYH3_k127_1471678_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.004e-234 734.0
PYH3_k127_1471678_40 - - - - 0.000000000000000000000000000000000000000000000000001778 186.0
PYH3_k127_1471678_41 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000005274 182.0
PYH3_k127_1471678_42 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000001068 182.0
PYH3_k127_1471678_43 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000398 171.0
PYH3_k127_1471678_44 cell adhesion involved in biofilm formation K02453 - - 0.0000000000000000000000000000000000000000000002141 192.0
PYH3_k127_1471678_45 PFAM phosphatidate cytidylyltransferase - - - 0.00000000000000000000000000000000000000000001671 168.0
PYH3_k127_1471678_46 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000003663 163.0
PYH3_k127_1471678_47 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000000003572 155.0
PYH3_k127_1471678_48 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000531 155.0
PYH3_k127_1471678_49 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000000000000008374 145.0
PYH3_k127_1471678_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.131e-231 722.0
PYH3_k127_1471678_50 Zinc-ribbon containing domain - - - 0.0000000000000000000000000000000001005 133.0
PYH3_k127_1471678_51 PFAM Rubrerythrin - - - 0.0000000000000000000000000000005715 126.0
PYH3_k127_1471678_52 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000007912 123.0
PYH3_k127_1471678_53 binds to the 23S rRNA K02922 - - 0.00000000000000000000000001916 108.0
PYH3_k127_1471678_54 chorismate mutase K04093 - 5.4.99.5 0.000000000000000000000000073 111.0
PYH3_k127_1471678_55 PBS lyase HEAT-like repeat - - - 0.000000000000000000000004297 104.0
PYH3_k127_1471678_56 membrane K09167 - - 0.000000000000000000000004483 108.0
PYH3_k127_1471678_57 PFAM Rubrerythrin - - - 0.00000000000000000000000481 102.0
PYH3_k127_1471678_58 - K00960 - 2.7.7.6 0.000000000000000000000006759 104.0
PYH3_k127_1471678_59 NADPH-dependent FMN reductase - - - 0.000000000000000002221 88.0
PYH3_k127_1471678_6 DEAD DEAH box helicase K03724 - - 6.622e-229 730.0
PYH3_k127_1471678_60 - - - - 0.0000000000000004892 80.0
PYH3_k127_1471678_61 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000003342 76.0
PYH3_k127_1471678_62 PFAM PKD domain containing protein - - - 0.0000000000004568 84.0
PYH3_k127_1471678_63 - - - - 0.0000000000007576 81.0
PYH3_k127_1471678_64 - - - - 0.00000000009234 76.0
PYH3_k127_1471678_65 Belongs to the UPF0248 family K09715 - - 0.0000000005708 62.0
PYH3_k127_1471678_66 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0002845 44.0
PYH3_k127_1471678_7 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 9.281e-224 704.0
PYH3_k127_1471678_8 Belongs to the aspartokinase family K00928 - 2.7.2.4 8.815e-208 654.0
PYH3_k127_1471678_9 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 595.0
PYH3_k127_1546902_0 Belongs to the glutamate synthase family - - - 4.512e-273 846.0
PYH3_k127_1546902_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 5.192e-236 736.0
PYH3_k127_1546902_10 PFAM glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 542.0
PYH3_k127_1546902_11 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 542.0
PYH3_k127_1546902_12 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 534.0
PYH3_k127_1546902_13 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 506.0
PYH3_k127_1546902_14 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 484.0
PYH3_k127_1546902_15 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 506.0
PYH3_k127_1546902_16 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 443.0
PYH3_k127_1546902_17 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 428.0
PYH3_k127_1546902_18 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 422.0
PYH3_k127_1546902_19 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008282 399.0
PYH3_k127_1546902_2 Ferrous iron transport B domain protein K04759 - - 1.096e-225 715.0
PYH3_k127_1546902_20 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 391.0
PYH3_k127_1546902_21 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 395.0
PYH3_k127_1546902_22 Papain family cysteine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 402.0
PYH3_k127_1546902_23 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 381.0
PYH3_k127_1546902_24 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 372.0
PYH3_k127_1546902_25 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 370.0
PYH3_k127_1546902_26 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 360.0
PYH3_k127_1546902_27 PFAM glutamate synthase alpha subunit domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 334.0
PYH3_k127_1546902_28 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 330.0
PYH3_k127_1546902_29 PFAM amino acid-binding ACT domain protein K06862 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 329.0
PYH3_k127_1546902_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.003e-211 662.0
PYH3_k127_1546902_30 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 307.0
PYH3_k127_1546902_31 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 297.0
PYH3_k127_1546902_32 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 298.0
PYH3_k127_1546902_33 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000004972 265.0
PYH3_k127_1546902_34 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001116 273.0
PYH3_k127_1546902_35 Spore germination protein K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005672 259.0
PYH3_k127_1546902_36 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000004071 238.0
PYH3_k127_1546902_37 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000000000000000000000000107 242.0
PYH3_k127_1546902_38 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000001188 222.0
PYH3_k127_1546902_39 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000004547 216.0
PYH3_k127_1546902_4 Helix-hairpin-helix domain K02347 - - 5.658e-199 634.0
PYH3_k127_1546902_40 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000001114 207.0
PYH3_k127_1546902_41 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000000000000000000000000000000000000006403 206.0
PYH3_k127_1546902_42 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000007372 201.0
PYH3_k127_1546902_43 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000004559 201.0
PYH3_k127_1546902_44 LysM domain - - - 0.000000000000000000000000000000000000000000000000267 192.0
PYH3_k127_1546902_45 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000006238 179.0
PYH3_k127_1546902_46 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000001154 182.0
PYH3_k127_1546902_47 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000000000000000000000000002294 174.0
PYH3_k127_1546902_48 Acetylglutamate kinase - - - 0.000000000000000000000000000000000000000000004741 179.0
PYH3_k127_1546902_49 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000000000000000005914 166.0
PYH3_k127_1546902_5 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 2.818e-198 620.0
PYH3_k127_1546902_50 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000005093 166.0
PYH3_k127_1546902_51 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000004846 156.0
PYH3_k127_1546902_52 iron dependent repressor K03709,K04758 - - 0.00000000000000000000000000000000000000002004 160.0
PYH3_k127_1546902_53 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000000001363 148.0
PYH3_k127_1546902_54 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing K00123,K00367,K00372,K08356 - 1.17.1.9,1.20.2.1,1.20.9.1,1.7.7.2 0.00000000000000000000000000000000000008734 141.0
PYH3_k127_1546902_55 - - - - 0.0000000000000000000000000000000000002507 146.0
PYH3_k127_1546902_56 - - - - 0.00000000000000000000000000000000007694 134.0
PYH3_k127_1546902_57 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000000000000000005648 136.0
PYH3_k127_1546902_58 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000004044 115.0
PYH3_k127_1546902_59 - - - - 0.0000000000000000000001307 104.0
PYH3_k127_1546902_6 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 594.0
PYH3_k127_1546902_60 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000006542 98.0
PYH3_k127_1546902_61 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000007721 93.0
PYH3_k127_1546902_62 PFAM TPR repeat-containing protein - - - 0.0000000000000002518 84.0
PYH3_k127_1546902_63 PFAM TPR repeat-containing protein - - - 0.0000000000000005081 83.0
PYH3_k127_1546902_64 - - - - 0.000000000000000739 78.0
PYH3_k127_1546902_65 PBS lyase HEAT-like repeat - - - 0.000000000000001844 83.0
PYH3_k127_1546902_66 PFAM PKD domain containing protein - - - 0.0000000000004216 79.0
PYH3_k127_1546902_68 PFAM Cation K03498 - - 0.0000000001397 64.0
PYH3_k127_1546902_69 Belongs to the peptidase S8 family - - - 0.0000000002522 75.0
PYH3_k127_1546902_7 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 595.0
PYH3_k127_1546902_70 - - - - 0.0000003772 53.0
PYH3_k127_1546902_8 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 589.0
PYH3_k127_1546902_9 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 561.0
PYH3_k127_1585221_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 589.0
PYH3_k127_1585221_1 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 338.0
PYH3_k127_1585221_2 Uncharacterised conserved protein UCP033563 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001186 250.0
PYH3_k127_1585221_3 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000139 203.0
PYH3_k127_1908631_0 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009476 404.0
PYH3_k127_2265614_0 PFAM Radical SAM domain protein K06937 - - 1.517e-244 762.0
PYH3_k127_2265614_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 609.0
PYH3_k127_2265614_10 Small multi-drug export protein - - - 0.00000000000000000000000000000000000000000001051 173.0
PYH3_k127_2265614_11 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000006707 152.0
PYH3_k127_2265614_12 Belongs to the UPF0235 family K09131 - - 0.000000000000000000001093 98.0
PYH3_k127_2265614_13 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000001508 90.0
PYH3_k127_2265614_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008273 554.0
PYH3_k127_2265614_3 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 437.0
PYH3_k127_2265614_4 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 422.0
PYH3_k127_2265614_5 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 359.0
PYH3_k127_2265614_6 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000000000000000000000000000000000001333 234.0
PYH3_k127_2265614_7 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000000000000000000002255 212.0
PYH3_k127_2265614_8 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000001354 185.0
PYH3_k127_2265614_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000001707 190.0
PYH3_k127_2301916_0 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 1.197e-236 741.0
PYH3_k127_2301916_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.71e-209 655.0
PYH3_k127_2301916_10 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 471.0
PYH3_k127_2301916_11 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 459.0
PYH3_k127_2301916_12 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 449.0
PYH3_k127_2301916_13 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 449.0
PYH3_k127_2301916_14 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 450.0
PYH3_k127_2301916_15 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 445.0
PYH3_k127_2301916_16 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 443.0
PYH3_k127_2301916_17 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 435.0
PYH3_k127_2301916_18 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 435.0
PYH3_k127_2301916_19 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 425.0
PYH3_k127_2301916_2 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.595e-208 661.0
PYH3_k127_2301916_20 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 416.0
PYH3_k127_2301916_21 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 416.0
PYH3_k127_2301916_22 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 375.0
PYH3_k127_2301916_23 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
PYH3_k127_2301916_24 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 359.0
PYH3_k127_2301916_25 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 355.0
PYH3_k127_2301916_26 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 349.0
PYH3_k127_2301916_27 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 328.0
PYH3_k127_2301916_28 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
PYH3_k127_2301916_29 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 307.0
PYH3_k127_2301916_3 PFAM peptidase U32 K08303 - - 7.624e-208 676.0
PYH3_k127_2301916_30 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 299.0
PYH3_k127_2301916_31 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000004946 266.0
PYH3_k127_2301916_32 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001971 251.0
PYH3_k127_2301916_33 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000004642 244.0
PYH3_k127_2301916_34 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000000000000000000001219 234.0
PYH3_k127_2301916_35 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000001425 221.0
PYH3_k127_2301916_36 - - - - 0.0000000000000000000000000000000000000000000000000000000000003487 214.0
PYH3_k127_2301916_37 - - - - 0.000000000000000000000000000000000000000000000000000000000001049 224.0
PYH3_k127_2301916_38 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000004003 188.0
PYH3_k127_2301916_39 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000000000003156 183.0
PYH3_k127_2301916_4 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 4.534e-202 635.0
PYH3_k127_2301916_40 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000006349 165.0
PYH3_k127_2301916_41 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000004194 155.0
PYH3_k127_2301916_42 - - - - 0.00000000000000000000000000000000000000003707 156.0
PYH3_k127_2301916_43 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000000000000004834 134.0
PYH3_k127_2301916_44 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000001309 101.0
PYH3_k127_2301916_45 - - - - 0.00000000000000000000003937 103.0
PYH3_k127_2301916_46 signal transduction protein with CBS domains - - - 0.000000000000000000001087 105.0
PYH3_k127_2301916_47 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000001628 92.0
PYH3_k127_2301916_48 structural constituent of ribosome K02962 - - 0.0000000000000000001538 89.0
PYH3_k127_2301916_49 signal transduction protein with CBS domains - - - 0.000000000000000007141 94.0
PYH3_k127_2301916_5 PFAM PUA domain containing protein K07557 - 2.6.1.97 1.13e-201 642.0
PYH3_k127_2301916_50 - - - - 0.0000000000007567 74.0
PYH3_k127_2301916_51 - - - - 0.00000000001161 66.0
PYH3_k127_2301916_52 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00176 - 1.2.7.3 0.0000000002981 64.0
PYH3_k127_2301916_53 protein kinase activity - - - 0.00002267 55.0
PYH3_k127_2301916_54 - - - - 0.0002688 48.0
PYH3_k127_2301916_6 LOR SDH bifunctional enzyme conserved - - - 3.557e-199 629.0
PYH3_k127_2301916_7 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 591.0
PYH3_k127_2301916_8 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 535.0
PYH3_k127_2301916_9 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 505.0
PYH3_k127_2505865_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1721.0
PYH3_k127_2505865_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1489.0
PYH3_k127_2505865_10 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 614.0
PYH3_k127_2505865_11 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 609.0
PYH3_k127_2505865_12 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 570.0
PYH3_k127_2505865_13 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 535.0
PYH3_k127_2505865_14 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 534.0
PYH3_k127_2505865_15 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 529.0
PYH3_k127_2505865_16 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 518.0
PYH3_k127_2505865_17 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 470.0
PYH3_k127_2505865_18 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 466.0
PYH3_k127_2505865_19 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 451.0
PYH3_k127_2505865_2 Heat shock 70 kDa protein K04043 - - 1.925e-319 985.0
PYH3_k127_2505865_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009156 400.0
PYH3_k127_2505865_21 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 383.0
PYH3_k127_2505865_22 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 368.0
PYH3_k127_2505865_23 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 365.0
PYH3_k127_2505865_24 RNA methylase K07446 - 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 362.0
PYH3_k127_2505865_25 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 341.0
PYH3_k127_2505865_26 40-residue YVTN family beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 349.0
PYH3_k127_2505865_27 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 307.0
PYH3_k127_2505865_28 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 306.0
PYH3_k127_2505865_29 PFAM metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 300.0
PYH3_k127_2505865_3 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.788e-316 977.0
PYH3_k127_2505865_30 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001538 271.0
PYH3_k127_2505865_31 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007501 274.0
PYH3_k127_2505865_32 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001423 269.0
PYH3_k127_2505865_33 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000002642 263.0
PYH3_k127_2505865_34 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002158 264.0
PYH3_k127_2505865_35 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000007703 215.0
PYH3_k127_2505865_36 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000000000000000000000000000000000006355 206.0
PYH3_k127_2505865_37 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000008248 215.0
PYH3_k127_2505865_38 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000000000001911 193.0
PYH3_k127_2505865_39 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000975 188.0
PYH3_k127_2505865_4 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 6.154e-291 900.0
PYH3_k127_2505865_40 DNA ligase D, 3-phosphoesterase domain - - - 0.000000000000000000000000000000000000000000000000003724 183.0
PYH3_k127_2505865_41 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000001663 180.0
PYH3_k127_2505865_42 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000002106 176.0
PYH3_k127_2505865_43 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000000000000001947 160.0
PYH3_k127_2505865_44 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000002413 159.0
PYH3_k127_2505865_45 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.00000000000000000000000000000000001206 142.0
PYH3_k127_2505865_46 COG0328 Ribonuclease HI K03469 - 3.1.26.4 0.000000000000000000000000000005503 124.0
PYH3_k127_2505865_47 - - - - 0.0000000000000000000000000001203 118.0
PYH3_k127_2505865_48 COG1881 Phospholipid-binding protein K06910 - - 0.0000000000000000000000000002286 119.0
PYH3_k127_2505865_49 fibronectin type III domain protein - - - 0.0000000000000000000000000003903 131.0
PYH3_k127_2505865_5 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 5.225e-273 855.0
PYH3_k127_2505865_50 - - - - 0.0000000000000000000000000006991 115.0
PYH3_k127_2505865_51 transcription factor (CBF NF-Y) - - - 0.000000000000000000000001062 104.0
PYH3_k127_2505865_52 - - - - 0.00000000000000000000000949 102.0
PYH3_k127_2505865_53 - - - - 0.0000000000000000000003986 106.0
PYH3_k127_2505865_55 - - - - 0.0000000000000000118 84.0
PYH3_k127_2505865_56 TIR domain - - - 0.00000000000000001864 87.0
PYH3_k127_2505865_57 - - - - 0.0000000000000005364 80.0
PYH3_k127_2505865_58 S-layer homology domain - - - 0.00000000000001199 87.0
PYH3_k127_2505865_59 Uncharacterised ArCR, COG2043 - - - 0.000001351 52.0
PYH3_k127_2505865_6 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 3.202e-238 744.0
PYH3_k127_2505865_60 CARDB - - - 0.00002457 57.0
PYH3_k127_2505865_7 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 7.792e-229 717.0
PYH3_k127_2505865_8 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 4.179e-208 652.0
PYH3_k127_2505865_9 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 1.782e-198 631.0
PYH3_k127_2510619_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1327.0
PYH3_k127_2510619_1 DEAD DEAH box helicase domain protein K10896 - - 2.696e-300 937.0
PYH3_k127_2510619_10 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 436.0
PYH3_k127_2510619_11 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 420.0
PYH3_k127_2510619_12 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 360.0
PYH3_k127_2510619_13 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 340.0
PYH3_k127_2510619_14 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 321.0
PYH3_k127_2510619_15 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 329.0
PYH3_k127_2510619_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 321.0
PYH3_k127_2510619_17 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 323.0
PYH3_k127_2510619_18 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 294.0
PYH3_k127_2510619_19 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 292.0
PYH3_k127_2510619_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 3.256e-280 872.0
PYH3_k127_2510619_20 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003898 284.0
PYH3_k127_2510619_21 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002414 282.0
PYH3_k127_2510619_22 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002879 272.0
PYH3_k127_2510619_23 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000007959 196.0
PYH3_k127_2510619_25 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000000000000000007567 176.0
PYH3_k127_2510619_26 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000003891 156.0
PYH3_k127_2510619_27 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000008786 151.0
PYH3_k127_2510619_28 - - - - 0.00000000000000000000000000000000000003217 147.0
PYH3_k127_2510619_29 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000002056 142.0
PYH3_k127_2510619_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.571e-217 693.0
PYH3_k127_2510619_30 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000002085 145.0
PYH3_k127_2510619_31 Prokaryotic RING finger family 2 - - - 0.0000000000000000000000000004836 117.0
PYH3_k127_2510619_32 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000004192 102.0
PYH3_k127_2510619_33 PDGLE domain K02009 - - 0.00000000000000000004299 102.0
PYH3_k127_2510619_34 - - - - 0.00000000000000000009725 94.0
PYH3_k127_2510619_36 - K02478 - 2.7.13.3 0.000000000000002022 79.0
PYH3_k127_2510619_37 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000008515 75.0
PYH3_k127_2510619_38 - K02478 - 2.7.13.3 0.00000000000002892 75.0
PYH3_k127_2510619_39 defense response to virus K07061 - - 0.00000000004492 69.0
PYH3_k127_2510619_4 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 4.958e-197 620.0
PYH3_k127_2510619_5 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 559.0
PYH3_k127_2510619_6 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 528.0
PYH3_k127_2510619_7 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 501.0
PYH3_k127_2510619_8 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 481.0
PYH3_k127_2510619_9 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 464.0
PYH3_k127_2702111_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1271.0
PYH3_k127_2702111_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 6.229e-306 945.0
PYH3_k127_2702111_10 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 6.005e-194 619.0
PYH3_k127_2702111_11 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 566.0
PYH3_k127_2702111_12 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 548.0
PYH3_k127_2702111_13 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 531.0
PYH3_k127_2702111_14 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 484.0
PYH3_k127_2702111_15 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 473.0
PYH3_k127_2702111_16 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 460.0
PYH3_k127_2702111_17 MviN-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009464 459.0
PYH3_k127_2702111_18 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 456.0
PYH3_k127_2702111_19 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 436.0
PYH3_k127_2702111_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.307e-285 893.0
PYH3_k127_2702111_20 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 429.0
PYH3_k127_2702111_21 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 403.0
PYH3_k127_2702111_22 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 407.0
PYH3_k127_2702111_23 PFAM peptidase M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 400.0
PYH3_k127_2702111_24 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 378.0
PYH3_k127_2702111_25 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 376.0
PYH3_k127_2702111_26 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 379.0
PYH3_k127_2702111_27 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 379.0
PYH3_k127_2702111_28 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 369.0
PYH3_k127_2702111_29 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 371.0
PYH3_k127_2702111_3 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 3.287e-247 772.0
PYH3_k127_2702111_30 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 365.0
PYH3_k127_2702111_31 methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 347.0
PYH3_k127_2702111_32 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 344.0
PYH3_k127_2702111_33 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 336.0
PYH3_k127_2702111_34 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 338.0
PYH3_k127_2702111_35 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 333.0
PYH3_k127_2702111_36 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 328.0
PYH3_k127_2702111_37 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 329.0
PYH3_k127_2702111_38 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 318.0
PYH3_k127_2702111_39 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 302.0
PYH3_k127_2702111_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 2.099e-242 758.0
PYH3_k127_2702111_40 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 288.0
PYH3_k127_2702111_41 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003231 282.0
PYH3_k127_2702111_42 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002859 270.0
PYH3_k127_2702111_43 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007149 268.0
PYH3_k127_2702111_44 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002468 259.0
PYH3_k127_2702111_45 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002273 265.0
PYH3_k127_2702111_46 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002044 252.0
PYH3_k127_2702111_47 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008288 244.0
PYH3_k127_2702111_48 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000000000000000000000000000177 242.0
PYH3_k127_2702111_49 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000002853 235.0
PYH3_k127_2702111_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 5.318e-242 759.0
PYH3_k127_2702111_50 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000000000000000000000000000000001144 224.0
PYH3_k127_2702111_51 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000001759 224.0
PYH3_k127_2702111_52 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000002899 212.0
PYH3_k127_2702111_53 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000001914 207.0
PYH3_k127_2702111_54 - - - - 0.00000000000000000000000000000000000000000000000000000004337 205.0
PYH3_k127_2702111_55 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000004247 192.0
PYH3_k127_2702111_56 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000007832 181.0
PYH3_k127_2702111_57 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000000000000000003683 181.0
PYH3_k127_2702111_58 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000006442 190.0
PYH3_k127_2702111_59 Ras family K06945 - - 0.000000000000000000000000000000000000000000000009933 177.0
PYH3_k127_2702111_6 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 3.757e-240 747.0
PYH3_k127_2702111_60 Coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.00000000000000000000000000000000000000000000001024 178.0
PYH3_k127_2702111_61 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000474 151.0
PYH3_k127_2702111_62 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000000000001711 139.0
PYH3_k127_2702111_63 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000003476 140.0
PYH3_k127_2702111_64 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000002147 131.0
PYH3_k127_2702111_65 protein conserved in archaea - - - 0.00000000000000000000000000000001247 129.0
PYH3_k127_2702111_66 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000000003698 123.0
PYH3_k127_2702111_67 Transcriptional regulator K07108 - - 0.000000000000000000000000000001001 124.0
PYH3_k127_2702111_68 transcriptional regulators K03724 - - 0.0000000000000000000000000003484 114.0
PYH3_k127_2702111_69 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000000000002319 113.0
PYH3_k127_2702111_7 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 3.006e-234 752.0
PYH3_k127_2702111_70 PFAM Yip1 domain - - - 0.000000000000000000000000004879 118.0
PYH3_k127_2702111_71 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00000000000000000000000006402 109.0
PYH3_k127_2702111_72 PFAM Protein kinase domain - - - 0.000000000000000000000001042 115.0
PYH3_k127_2702111_73 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000646 104.0
PYH3_k127_2702111_74 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000000004577 98.0
PYH3_k127_2702111_75 - - - - 0.00000000000000000000009373 106.0
PYH3_k127_2702111_76 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000003582 94.0
PYH3_k127_2702111_77 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000000591 94.0
PYH3_k127_2702111_78 - - - - 0.00000000000000009004 81.0
PYH3_k127_2702111_79 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000001782 83.0
PYH3_k127_2702111_8 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 6.06e-224 699.0
PYH3_k127_2702111_80 nucleic acid binding OB-fold tRNA helicase-type - - - 0.000000000000003404 80.0
PYH3_k127_2702111_81 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000423 75.0
PYH3_k127_2702111_82 - - - - 0.00000000002268 68.0
PYH3_k127_2702111_9 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 7.985e-215 672.0
PYH3_k127_2744199_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.756e-258 799.0
PYH3_k127_2744199_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.658e-240 745.0
PYH3_k127_2744199_10 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 573.0
PYH3_k127_2744199_11 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 556.0
PYH3_k127_2744199_12 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 542.0
PYH3_k127_2744199_13 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 520.0
PYH3_k127_2744199_14 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 512.0
PYH3_k127_2744199_15 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 481.0
PYH3_k127_2744199_16 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 484.0
PYH3_k127_2744199_17 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 443.0
PYH3_k127_2744199_18 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 438.0
PYH3_k127_2744199_19 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 434.0
PYH3_k127_2744199_2 Uncharacterized membrane protein (DUF2298) - - - 2.244e-226 722.0
PYH3_k127_2744199_20 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 406.0
PYH3_k127_2744199_21 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 405.0
PYH3_k127_2744199_22 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 385.0
PYH3_k127_2744199_23 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 304.0
PYH3_k127_2744199_24 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 294.0
PYH3_k127_2744199_25 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 287.0
PYH3_k127_2744199_26 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 289.0
PYH3_k127_2744199_27 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 290.0
PYH3_k127_2744199_28 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 282.0
PYH3_k127_2744199_29 COG0433 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001415 270.0
PYH3_k127_2744199_3 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 1.006e-224 702.0
PYH3_k127_2744199_30 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007312 259.0
PYH3_k127_2744199_31 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001297 246.0
PYH3_k127_2744199_32 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000104 232.0
PYH3_k127_2744199_33 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000003812 222.0
PYH3_k127_2744199_34 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000306 218.0
PYH3_k127_2744199_35 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000001864 205.0
PYH3_k127_2744199_36 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000006733 199.0
PYH3_k127_2744199_37 - - - - 0.0000000000000000000000000000000000000000000000000005362 198.0
PYH3_k127_2744199_38 PFAM metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000001868 186.0
PYH3_k127_2744199_39 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000002752 169.0
PYH3_k127_2744199_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 7.642e-205 649.0
PYH3_k127_2744199_40 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000156 161.0
PYH3_k127_2744199_41 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.000000000000000000000000000000000000000005867 158.0
PYH3_k127_2744199_42 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000324 155.0
PYH3_k127_2744199_43 - - - - 0.000000000000000000000000000000000000003796 154.0
PYH3_k127_2744199_44 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000876 147.0
PYH3_k127_2744199_45 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000002887 134.0
PYH3_k127_2744199_46 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000001412 124.0
PYH3_k127_2744199_47 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000003484 114.0
PYH3_k127_2744199_48 helicase activity K06915 - - 0.000000000000000000000000005133 116.0
PYH3_k127_2744199_49 Rhodanese Homology Domain - - - 0.0000000000000000000000001553 110.0
PYH3_k127_2744199_5 Involved in cell shape control K22222 - - 7.975e-197 621.0
PYH3_k127_2744199_50 - - - - 0.0000000000000000000000006239 109.0
PYH3_k127_2744199_51 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000003533 105.0
PYH3_k127_2744199_52 Putative small multi-drug export protein - - - 0.000000000000000000444 93.0
PYH3_k127_2744199_6 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 607.0
PYH3_k127_2744199_7 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 597.0
PYH3_k127_2744199_8 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 603.0
PYH3_k127_2744199_9 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 597.0
PYH3_k127_2845944_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 4.153e-254 799.0
PYH3_k127_2845944_1 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 2.445e-223 697.0
PYH3_k127_2845944_10 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004296 232.0
PYH3_k127_2845944_11 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000004408 222.0
PYH3_k127_2845944_12 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000002631 221.0
PYH3_k127_2845944_13 - - - - 0.0000000000000000000000000000000000000000000000000000007167 197.0
PYH3_k127_2845944_14 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000000000000000000007493 194.0
PYH3_k127_2845944_15 Nitroreductase - - - 0.000000000000000000000000000000000000000000000006295 185.0
PYH3_k127_2845944_16 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000004522 173.0
PYH3_k127_2845944_17 - - - - 0.0000000000000000000000000000000000000003116 158.0
PYH3_k127_2845944_18 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000000000000000000003817 141.0
PYH3_k127_2845944_19 PFAM helix-turn-helix domain protein K07729 - - 0.000000000000000000000000000193 116.0
PYH3_k127_2845944_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 466.0
PYH3_k127_2845944_20 Molybdopterin oxidoreductase K00201 - 1.2.7.12 0.0000000000000000000005511 95.0
PYH3_k127_2845944_21 PFAM Uncharacterised protein family UPF0066 - - - 0.0000000000000000001405 91.0
PYH3_k127_2845944_22 transcriptional regulators K03724 - - 0.0000000000000000634 82.0
PYH3_k127_2845944_23 Rubredoxin - - - 0.000000000000001586 79.0
PYH3_k127_2845944_24 PQ loop repeat K15383 - - 0.00000004942 59.0
PYH3_k127_2845944_25 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.00002032 48.0
PYH3_k127_2845944_3 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 414.0
PYH3_k127_2845944_4 methanogenesis marker protein 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 418.0
PYH3_k127_2845944_5 permease K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 394.0
PYH3_k127_2845944_6 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 388.0
PYH3_k127_2845944_7 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 338.0
PYH3_k127_2845944_8 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 312.0
PYH3_k127_2845944_9 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 301.0
PYH3_k127_2869195_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 576.0
PYH3_k127_2869195_1 PFAM DNA RNA helicase, DEAD DEAH box type, N-terminal K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 469.0
PYH3_k127_301765_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 407.0
PYH3_k127_301765_1 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 400.0
PYH3_k127_301765_2 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 368.0
PYH3_k127_301765_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 333.0
PYH3_k127_301765_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007911 282.0
PYH3_k127_301765_5 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000000004316 169.0
PYH3_k127_301765_6 - - - - 0.0000000000000000000000000000000000000000000006033 171.0
PYH3_k127_301765_7 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0000000000000000000000000000000000001475 142.0
PYH3_k127_301765_8 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000004897 104.0
PYH3_k127_301765_9 - - - - 0.00000000000000000007179 91.0
PYH3_k127_3074909_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 5.329e-198 625.0
PYH3_k127_3074909_1 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 440.0
PYH3_k127_3074909_10 PcfJ-like protein - - - 0.0008481 45.0
PYH3_k127_3074909_2 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 317.0
PYH3_k127_3074909_4 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000002232 241.0
PYH3_k127_3074909_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000004944 136.0
PYH3_k127_3074909_6 Flavodoxin - GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000006224 125.0
PYH3_k127_3074909_7 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000004693 107.0
PYH3_k127_3074909_8 - - - - 0.0000000000002091 73.0
PYH3_k127_3074909_9 META domain - - - 0.00000004023 61.0
PYH3_k127_3086666_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1087.0
PYH3_k127_3086666_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.619e-237 757.0
PYH3_k127_3086666_2 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000000000003094 108.0
PYH3_k127_3086666_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000004855 100.0
PYH3_k127_312592_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1021.0
PYH3_k127_312592_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 7.69e-320 992.0
PYH3_k127_312592_10 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 446.0
PYH3_k127_312592_11 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 427.0
PYH3_k127_312592_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 415.0
PYH3_k127_312592_13 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 351.0
PYH3_k127_312592_14 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 347.0
PYH3_k127_312592_15 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 333.0
PYH3_k127_312592_16 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 331.0
PYH3_k127_312592_17 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008754 275.0
PYH3_k127_312592_18 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001516 278.0
PYH3_k127_312592_19 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
PYH3_k127_312592_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 6.619e-279 860.0
PYH3_k127_312592_20 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002901 241.0
PYH3_k127_312592_21 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000000000000000000000000000000000007969 226.0
PYH3_k127_312592_22 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000000000000000000000000002806 221.0
PYH3_k127_312592_23 ATP-dependent DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000001549 208.0
PYH3_k127_312592_24 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000003157 205.0
PYH3_k127_312592_25 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000000000000000000000005172 209.0
PYH3_k127_312592_26 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000000000000000000000004654 169.0
PYH3_k127_312592_27 - - - - 0.000000000000000000000000000000000000000006291 162.0
PYH3_k127_312592_28 - - - - 0.000000000000000000000000000000000008749 139.0
PYH3_k127_312592_29 Glutaredoxin - - - 0.0000000000000000000000000000000002621 136.0
PYH3_k127_312592_3 Uncharacterized protein conserved in archaea (DUF2114) - - - 4.263e-259 807.0
PYH3_k127_312592_30 protein possibly involved in aromatic compounds catabolism K02614 - - 0.000000000000000000000000000008832 123.0
PYH3_k127_312592_31 - - - - 0.00000000000000000000006187 100.0
PYH3_k127_312592_32 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000001282 97.0
PYH3_k127_312592_33 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000007466 91.0
PYH3_k127_312592_34 DNA polymerase Ligase (LigD) - - - 0.00000000000000007427 81.0
PYH3_k127_312592_35 - - - - 0.000000000000003831 81.0
PYH3_k127_312592_37 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.0000004548 53.0
PYH3_k127_312592_4 PFAM chaperonin Cpn60 TCP-1 K22447 - - 3.239e-242 758.0
PYH3_k127_312592_5 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.195e-226 720.0
PYH3_k127_312592_6 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 1.643e-202 646.0
PYH3_k127_312592_7 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 606.0
PYH3_k127_312592_8 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 592.0
PYH3_k127_312592_9 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 583.0
PYH3_k127_3135100_0 PFAM ribonuclease II K01147 - 3.1.13.1 1.452e-215 683.0
PYH3_k127_3135100_1 Polyphosphate kinase 2 (PPK2) - - - 2.885e-197 628.0
PYH3_k127_3135100_10 Rubrerythrin - - - 0.00001817 50.0
PYH3_k127_3135100_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 406.0
PYH3_k127_3135100_3 COG1520 FOG WD40-like repeat - - - 0.00000000000000000000000000000000000000000000002392 184.0
PYH3_k127_3135100_4 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000005144 149.0
PYH3_k127_3135100_5 - - - - 0.0000000000000000000000002253 116.0
PYH3_k127_3135100_6 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000004112 91.0
PYH3_k127_3135100_7 Protein of unknown function (DUF998) - - - 0.00000000000004805 81.0
PYH3_k127_3135100_8 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000001837 64.0
PYH3_k127_3135100_9 - - - - 0.000002892 55.0
PYH3_k127_3225705_0 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 451.0
PYH3_k127_3225705_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000001636 183.0
PYH3_k127_3225705_2 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000003076 146.0
PYH3_k127_3225705_3 SpoVT / AbrB like domain - - - 0.000000000000000000000000001442 114.0
PYH3_k127_3333140_0 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008959 299.0
PYH3_k127_3333140_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
PYH3_k127_3333140_2 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003397 284.0
PYH3_k127_3333140_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000004743 168.0
PYH3_k127_3593046_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 4.828e-232 731.0
PYH3_k127_3593046_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 407.0
PYH3_k127_3593046_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002557 280.0
PYH3_k127_3593046_3 - - - - 0.0000000000000000000000000000000000000000000000000000002909 198.0
PYH3_k127_3593046_4 TIR domain - - - 0.000000000000001362 82.0
PYH3_k127_3765818_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.956e-240 762.0
PYH3_k127_3765818_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007337 524.0
PYH3_k127_3765818_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001343 284.0
PYH3_k127_3765818_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000002892 238.0
PYH3_k127_3765818_4 CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000219 213.0
PYH3_k127_3765818_5 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000001245 199.0
PYH3_k127_3765818_6 - - - - 0.00000000000003306 78.0
PYH3_k127_3765818_7 - K06193 - - 0.0000000001906 64.0
PYH3_k127_3778365_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 5.197e-251 779.0
PYH3_k127_3778365_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.035e-209 666.0
PYH3_k127_3778365_10 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 354.0
PYH3_k127_3778365_11 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 344.0
PYH3_k127_3778365_12 PFAM GTP-binding protein HSR1-related K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008403 343.0
PYH3_k127_3778365_13 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 343.0
PYH3_k127_3778365_14 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 341.0
PYH3_k127_3778365_15 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 287.0
PYH3_k127_3778365_16 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001721 274.0
PYH3_k127_3778365_17 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001026 264.0
PYH3_k127_3778365_18 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005659 262.0
PYH3_k127_3778365_19 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005595 256.0
PYH3_k127_3778365_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 3.991e-195 629.0
PYH3_k127_3778365_20 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001558 243.0
PYH3_k127_3778365_21 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000001303 221.0
PYH3_k127_3778365_22 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000001949 218.0
PYH3_k127_3778365_23 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000003889 204.0
PYH3_k127_3778365_24 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000001937 199.0
PYH3_k127_3778365_25 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000005487 196.0
PYH3_k127_3778365_26 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000000062 176.0
PYH3_k127_3778365_27 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000009174 170.0
PYH3_k127_3778365_28 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000002448 180.0
PYH3_k127_3778365_29 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000000002881 130.0
PYH3_k127_3778365_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 565.0
PYH3_k127_3778365_30 - - - - 0.0000000000000000000000000141 110.0
PYH3_k127_3778365_31 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000003684 113.0
PYH3_k127_3778365_32 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000000008205 98.0
PYH3_k127_3778365_4 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 485.0
PYH3_k127_3778365_5 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 455.0
PYH3_k127_3778365_6 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 441.0
PYH3_k127_3778365_7 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 419.0
PYH3_k127_3778365_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 374.0
PYH3_k127_3778365_9 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 371.0
PYH3_k127_38130_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 566.0
PYH3_k127_38130_1 PFAM sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 511.0
PYH3_k127_38130_10 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 386.0
PYH3_k127_38130_11 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 301.0
PYH3_k127_38130_12 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001972 273.0
PYH3_k127_38130_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002829 275.0
PYH3_k127_38130_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001652 270.0
PYH3_k127_38130_15 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008658 246.0
PYH3_k127_38130_16 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000023 186.0
PYH3_k127_38130_17 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000002378 164.0
PYH3_k127_38130_18 - - - - 0.0000000000000000000000000004898 117.0
PYH3_k127_38130_19 Regulatory protein MarR - - - 0.00000000000000000000000001782 113.0
PYH3_k127_38130_2 Pas domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 513.0
PYH3_k127_38130_20 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000001346 105.0
PYH3_k127_38130_21 PspC domain K03973 - - 0.0000000000000000006473 88.0
PYH3_k127_38130_22 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000008698 93.0
PYH3_k127_38130_23 Ion channel - - - 0.000000000000001602 89.0
PYH3_k127_38130_24 - - - - 0.000000000000001822 79.0
PYH3_k127_38130_25 - - - - 0.0000000000001343 81.0
PYH3_k127_38130_26 TIR domain - - - 0.000000000001529 73.0
PYH3_k127_38130_27 PFAM TPR repeat-containing protein - - - 0.00000000001109 71.0
PYH3_k127_38130_29 deoxyhypusine monooxygenase activity K06921 - - 0.00003848 52.0
PYH3_k127_38130_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 463.0
PYH3_k127_38130_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 445.0
PYH3_k127_38130_5 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 435.0
PYH3_k127_38130_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 426.0
PYH3_k127_38130_7 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 424.0
PYH3_k127_38130_8 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 408.0
PYH3_k127_38130_9 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 389.0
PYH3_k127_3852980_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 475.0
PYH3_k127_3852980_1 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 460.0
PYH3_k127_3852980_2 PFAM glutamate--cysteine ligase, GCS2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 400.0
PYH3_k127_3852980_3 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006554 341.0
PYH3_k127_3852980_4 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000006549 224.0
PYH3_k127_3852980_5 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000003951 183.0
PYH3_k127_3852980_6 Thioredoxin - - - 0.0000000000000000000000000000000000000000003576 164.0
PYH3_k127_3852980_7 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000004954 60.0
PYH3_k127_4336300_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 364.0
PYH3_k127_4336300_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000002026 180.0
PYH3_k127_4336300_2 Flavodoxin - - - 0.000000000000000000000000000000000000000004846 160.0
PYH3_k127_4336300_3 - - - - 0.0000000001842 70.0
PYH3_k127_4374960_0 Belongs to the MCM family K10726 - - 0.0 1077.0
PYH3_k127_4374960_1 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 586.0
PYH3_k127_4374960_10 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002473 245.0
PYH3_k127_4374960_11 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000001258 237.0
PYH3_k127_4374960_12 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000000003878 131.0
PYH3_k127_4374960_13 Papain family cysteine protease - - - 0.000000000000000000000000000003454 135.0
PYH3_k127_4374960_14 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000000009062 120.0
PYH3_k127_4374960_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 507.0
PYH3_k127_4374960_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 461.0
PYH3_k127_4374960_4 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 376.0
PYH3_k127_4374960_5 Replication factor C K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 355.0
PYH3_k127_4374960_6 pfam nmd3 K07562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 335.0
PYH3_k127_4374960_7 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 308.0
PYH3_k127_4374960_8 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 301.0
PYH3_k127_4374960_9 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000006383 264.0
PYH3_k127_4926924_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 540.0
PYH3_k127_4926924_1 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000000000003656 184.0
PYH3_k127_4926924_2 - - - - 0.0000000000000000000000000003268 121.0
PYH3_k127_4926924_3 PFAM Uncharacterised conserved protein UCP006577 - - - 0.000005992 53.0
PYH3_k127_5004577_0 Sulfatase K01130 - 3.1.6.1 4.056e-316 979.0
PYH3_k127_5004577_1 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 557.0
PYH3_k127_5004577_10 - - - - 0.00000000003396 70.0
PYH3_k127_5004577_11 Transposase DDE domain - - - 0.00000006016 57.0
PYH3_k127_5004577_12 Short repeat of unknown function (DUF308) - - - 0.0002032 51.0
PYH3_k127_5004577_2 Sulfate permease family K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 464.0
PYH3_k127_5004577_3 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 411.0
PYH3_k127_5004577_4 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001562 268.0
PYH3_k127_5004577_5 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
PYH3_k127_5004577_6 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000000000006505 210.0
PYH3_k127_5004577_7 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000003464 202.0
PYH3_k127_5004577_8 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000003876 195.0
PYH3_k127_5004577_9 Flavodoxin - - - 0.0000000000000000000000000000001292 132.0
PYH3_k127_5276424_0 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 539.0
PYH3_k127_5276424_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 507.0
PYH3_k127_5276424_11 Short C-terminal domain - - - 0.000000005027 61.0
PYH3_k127_5276424_12 - - - - 0.0000001939 60.0
PYH3_k127_5276424_13 Domain of unknown function (DUF3821) - - - 0.0000003413 53.0
PYH3_k127_5276424_14 VIT family - - - 0.000001304 58.0
PYH3_k127_5276424_2 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 443.0
PYH3_k127_5276424_3 Alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 364.0
PYH3_k127_5276424_4 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000003504 237.0
PYH3_k127_5276424_5 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000002377 169.0
PYH3_k127_5276424_6 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000007501 153.0
PYH3_k127_5276424_7 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000001954 139.0
PYH3_k127_5276424_8 membrane protein of uknown function UCP014873 - - - 0.00000000000000000000005913 104.0
PYH3_k127_5276424_9 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000402 101.0
PYH3_k127_5385965_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1403.0
PYH3_k127_5385965_1 PFAM PilT protein domain protein K06865 - - 2.029e-303 940.0
PYH3_k127_5385965_10 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 355.0
PYH3_k127_5385965_11 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000009301 268.0
PYH3_k127_5385965_12 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000005819 192.0
PYH3_k127_5385965_13 Roadblock LC7 K07131 - - 0.0000000000000000000000000000000000000000000000000001555 186.0
PYH3_k127_5385965_14 Protein of unknown function (DUF473) K09135 - - 0.000000000000000000000000000000000000000002447 160.0
PYH3_k127_5385965_15 - - - - 0.00000000000000000000000000000000000000007051 158.0
PYH3_k127_5385965_16 - - - - 0.0000000000000000000000000000000000109 138.0
PYH3_k127_5385965_17 Roadblock LC7 - - - 0.000000000000000000000000000004726 125.0
PYH3_k127_5385965_18 - - - - 0.0000000000000000000000000744 115.0
PYH3_k127_5385965_19 COG1403 Restriction endonuclease K10726 - - 0.0000001646 54.0
PYH3_k127_5385965_2 PFAM type II secretion system protein E K07332 - - 9.429e-276 865.0
PYH3_k127_5385965_20 - - - - 0.0000002532 59.0
PYH3_k127_5385965_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 6.903e-274 853.0
PYH3_k127_5385965_4 PFAM 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 603.0
PYH3_k127_5385965_5 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 575.0
PYH3_k127_5385965_6 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 385.0
PYH3_k127_5385965_7 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 377.0
PYH3_k127_5385965_8 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 369.0
PYH3_k127_5385965_9 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 356.0
PYH3_k127_5463233_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1401.0
PYH3_k127_5463233_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1295.0
PYH3_k127_5463233_10 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 318.0
PYH3_k127_5463233_11 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 297.0
PYH3_k127_5463233_12 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 310.0
PYH3_k127_5463233_13 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 309.0
PYH3_k127_5463233_14 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008881 282.0
PYH3_k127_5463233_15 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000063 276.0
PYH3_k127_5463233_16 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001714 268.0
PYH3_k127_5463233_17 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000007341 266.0
PYH3_k127_5463233_18 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000000002178 256.0
PYH3_k127_5463233_19 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000005169 255.0
PYH3_k127_5463233_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1249.0
PYH3_k127_5463233_20 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001529 249.0
PYH3_k127_5463233_21 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004558 241.0
PYH3_k127_5463233_22 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000000000001175 236.0
PYH3_k127_5463233_23 PFAM Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000103 238.0
PYH3_k127_5463233_24 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000000000000008674 207.0
PYH3_k127_5463233_25 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000002299 200.0
PYH3_k127_5463233_26 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000001122 184.0
PYH3_k127_5463233_27 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000001346 189.0
PYH3_k127_5463233_28 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.000000000000000000000000000000000000000000000005754 178.0
PYH3_k127_5463233_29 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000005517 174.0
PYH3_k127_5463233_3 PFAM CBS domain - - - 1.026e-250 781.0
PYH3_k127_5463233_30 - - - - 0.00000000000000000000000000000000000000000001272 166.0
PYH3_k127_5463233_31 - - - - 0.00000000000000000000000000000000000000005842 161.0
PYH3_k127_5463233_32 - - - - 0.000000000000000000000000000000000008363 149.0
PYH3_k127_5463233_33 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000003879 137.0
PYH3_k127_5463233_34 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000000000000001501 136.0
PYH3_k127_5463233_35 zinc finger, SWIM - - - 0.000000000000000000000000000000006976 130.0
PYH3_k127_5463233_36 NADH-Ubiquinone plastoquinone (complex I) K05568,K14115 - - 0.00000000000000000000000000000002505 130.0
PYH3_k127_5463233_37 - - - - 0.00000000000000000000000000004224 124.0
PYH3_k127_5463233_38 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000005418 118.0
PYH3_k127_5463233_39 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.0000000000000000000000001324 109.0
PYH3_k127_5463233_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 7.818e-228 713.0
PYH3_k127_5463233_40 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.0000000000000000000000008377 106.0
PYH3_k127_5463233_41 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000007816 106.0
PYH3_k127_5463233_42 Domain of unknown function (DUF4040) - - - 0.0000000000000000000103 96.0
PYH3_k127_5463233_43 - - - - 0.0000000000000000009921 88.0
PYH3_k127_5463233_44 Membrane bound hydrogenase - - - 0.00000000000000034 81.0
PYH3_k127_5463233_45 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.00000000000006798 74.0
PYH3_k127_5463233_5 TGS domain protein K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 548.0
PYH3_k127_5463233_6 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 550.0
PYH3_k127_5463233_7 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 412.0
PYH3_k127_5463233_8 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 412.0
PYH3_k127_5463233_9 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 323.0
PYH3_k127_5475129_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1602.0
PYH3_k127_5475129_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1071.0
PYH3_k127_5475129_10 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 404.0
PYH3_k127_5475129_11 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 395.0
PYH3_k127_5475129_12 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 359.0
PYH3_k127_5475129_13 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 356.0
PYH3_k127_5475129_14 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 288.0
PYH3_k127_5475129_15 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004145 262.0
PYH3_k127_5475129_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001143 243.0
PYH3_k127_5475129_17 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000008026 235.0
PYH3_k127_5475129_18 COG0590 Cytosine adenosine deaminases K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
PYH3_k127_5475129_19 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000000000000000000734 228.0
PYH3_k127_5475129_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1047.0
PYH3_k127_5475129_20 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000006466 228.0
PYH3_k127_5475129_21 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000000003651 181.0
PYH3_k127_5475129_22 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.000000000000000000000000000000000000000006141 157.0
PYH3_k127_5475129_23 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000000000000000001967 136.0
PYH3_k127_5475129_24 HEAT repeats - - - 0.000000000000000000000000000000007541 133.0
PYH3_k127_5475129_25 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000001603 94.0
PYH3_k127_5475129_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1022.0
PYH3_k127_5475129_4 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 3.313e-314 965.0
PYH3_k127_5475129_5 Conserved region in glutamate synthase - - - 2.345e-294 908.0
PYH3_k127_5475129_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 9.958e-205 641.0
PYH3_k127_5475129_7 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 540.0
PYH3_k127_5475129_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 518.0
PYH3_k127_5475129_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 443.0
PYH3_k127_6152557_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1219.0
PYH3_k127_6152557_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1184.0
PYH3_k127_6152557_10 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000005803 123.0
PYH3_k127_6152557_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1009.0
PYH3_k127_6152557_3 Nitrogenase component 1 type Oxidoreductase K02587 - - 3.435e-275 850.0
PYH3_k127_6152557_4 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 6.506e-241 751.0
PYH3_k127_6152557_5 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 484.0
PYH3_k127_6152557_6 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 423.0
PYH3_k127_6152557_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 350.0
PYH3_k127_6152557_8 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 320.0
PYH3_k127_6152557_9 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000001325 211.0
PYH3_k127_6202276_0 PFAM Thiolase K00626 - 2.3.1.9 9.139e-211 659.0
PYH3_k127_6202276_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000505 597.0
PYH3_k127_6202276_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 569.0
PYH3_k127_6202276_3 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 364.0
PYH3_k127_6202276_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 315.0
PYH3_k127_6202276_5 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 308.0
PYH3_k127_6202276_6 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 287.0
PYH3_k127_6202276_7 Helix-turn-helix domain protein K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004943 253.0
PYH3_k127_6202276_8 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000009534 104.0
PYH3_k127_6202276_9 Ferredoxin K05337 - - 0.00000000000000003821 83.0
PYH3_k127_6260196_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 5.549e-244 762.0
PYH3_k127_6260196_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 2.601e-205 652.0
PYH3_k127_6260196_10 PFAM PUA domain containing protein K07398 - - 0.0000000000000000000000000000000000000003662 154.0
PYH3_k127_6260196_11 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000001509 150.0
PYH3_k127_6260196_12 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000001829 161.0
PYH3_k127_6260196_13 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000003923 114.0
PYH3_k127_6260196_14 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000000000001501 97.0
PYH3_k127_6260196_15 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000001408 90.0
PYH3_k127_6260196_16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000003878 89.0
PYH3_k127_6260196_17 Belongs to the peptidase S8 family - - - 0.000000004548 71.0
PYH3_k127_6260196_18 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000372 50.0
PYH3_k127_6260196_19 PhoD-like phosphatase K01113 - 3.1.3.1 0.00001024 57.0
PYH3_k127_6260196_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 597.0
PYH3_k127_6260196_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009198 417.0
PYH3_k127_6260196_4 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 355.0
PYH3_k127_6260196_5 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 307.0
PYH3_k127_6260196_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000006518 213.0
PYH3_k127_6260196_7 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000000001304 196.0
PYH3_k127_6260196_8 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000007945 155.0
PYH3_k127_6260196_9 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000000000001225 152.0
PYH3_k127_6475809_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1850.0
PYH3_k127_6475809_1 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1232.0
PYH3_k127_6475809_10 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005911 269.0
PYH3_k127_6475809_11 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006932 271.0
PYH3_k127_6475809_12 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004272 248.0
PYH3_k127_6475809_13 Protein of unknown function (DUF432) K09149 - - 0.00000000000000000000000000000000000000000000000000000000000376 215.0
PYH3_k127_6475809_14 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000000000000005076 204.0
PYH3_k127_6475809_15 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000000000000000000000004049 167.0
PYH3_k127_6475809_16 - - - - 0.000000000000000000000000000000000000183 146.0
PYH3_k127_6475809_17 - - - - 0.000000000000000000000000000000000005066 143.0
PYH3_k127_6475809_18 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000174 127.0
PYH3_k127_6475809_19 Protein of unknown function DUF86 K07075 - - 0.00000000000000000000003824 108.0
PYH3_k127_6475809_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 9.998e-212 666.0
PYH3_k127_6475809_20 Domain of unknown function (DUF3821) - - - 0.000000000000687 76.0
PYH3_k127_6475809_21 SMART PAS domain containing protein - - - 0.00000000002457 76.0
PYH3_k127_6475809_22 - - - - 0.0000003198 57.0
PYH3_k127_6475809_3 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 579.0
PYH3_k127_6475809_4 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 527.0
PYH3_k127_6475809_5 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 518.0
PYH3_k127_6475809_6 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 483.0
PYH3_k127_6475809_7 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 402.0
PYH3_k127_6475809_8 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 373.0
PYH3_k127_6475809_9 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 330.0
PYH3_k127_6513492_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006974 458.0
PYH3_k127_6513492_1 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 297.0
PYH3_k127_6513492_2 Ribonuclease K03469 - 3.1.26.4 0.000000000000000000000001525 111.0
PYH3_k127_6552838_0 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001815 231.0
PYH3_k127_6552838_1 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000005967 179.0
PYH3_k127_6552838_2 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000367 138.0
PYH3_k127_6552838_3 DNA-binding transcription factor activity K03892 - - 0.0000000000000000000001355 104.0
PYH3_k127_6552838_4 Transcription elongation factor K03145 GO:0000003,GO:0001101,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0008150,GO:0009719,GO:0009725,GO:0009739,GO:0009791,GO:0009845,GO:0009889,GO:0009909,GO:0009910,GO:0010033,GO:0010154,GO:0010162,GO:0010431,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0021700,GO:0022414,GO:0022611,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032504,GO:0032784,GO:0033993,GO:0034243,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048316,GO:0048519,GO:0048580,GO:0048581,GO:0048608,GO:0048609,GO:0048731,GO:0048831,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051171,GO:0051239,GO:0051241,GO:0051252,GO:0060255,GO:0061458,GO:0065007,GO:0071695,GO:0080090,GO:0090351,GO:1901700,GO:1903506,GO:2000026,GO:2000112,GO:2000241,GO:2000242,GO:2001141 - 0.0002586 47.0
PYH3_k127_6577021_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1019.0
PYH3_k127_6577021_1 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 8.218e-213 666.0
PYH3_k127_6577021_10 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000009974 214.0
PYH3_k127_6577021_11 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000443 196.0
PYH3_k127_6577021_12 Matrixin - - - 0.0000000000000000000000000000000000003371 149.0
PYH3_k127_6577021_13 NLP P60 protein - - - 0.0000000000000000000000000000000000006837 147.0
PYH3_k127_6577021_14 - - - - 0.000000000000000000000000000000000296 134.0
PYH3_k127_6577021_15 Mur ligase K01932 - - 0.0000000000000000000000000000004487 137.0
PYH3_k127_6577021_16 - - - - 0.0000000000000000000000000000004559 124.0
PYH3_k127_6577021_17 - - - - 0.0000000000001351 73.0
PYH3_k127_6577021_18 Capsule biosynthesis CapC - - - 0.00000000005485 70.0
PYH3_k127_6577021_19 CHY zinc finger K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000007375 70.0
PYH3_k127_6577021_2 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 563.0
PYH3_k127_6577021_20 PFAM aminotransferase class V - - - 0.000000004202 59.0
PYH3_k127_6577021_22 - - - - 0.0000585 47.0
PYH3_k127_6577021_3 PFAM Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 563.0
PYH3_k127_6577021_4 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008268 435.0
PYH3_k127_6577021_5 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 366.0
PYH3_k127_6577021_6 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 357.0
PYH3_k127_6577021_7 Thiopurine S-methyltransferase (TPMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009878 277.0
PYH3_k127_6577021_8 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005352 262.0
PYH3_k127_6577021_9 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000001291 237.0
PYH3_k127_7213185_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.396e-291 901.0
PYH3_k127_7213185_1 PFAM dihydropteroate synthase, DHPS - - - 1.031e-195 620.0
PYH3_k127_7213185_10 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000003333 221.0
PYH3_k127_7213185_11 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000000000000002847 199.0
PYH3_k127_7213185_12 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000000000024 192.0
PYH3_k127_7213185_13 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000000000000000000000000000000002724 181.0
PYH3_k127_7213185_14 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.0000000000000000000000000000000000003895 141.0
PYH3_k127_7213185_15 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000014 141.0
PYH3_k127_7213185_16 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.000000000000000000000000000000001684 135.0
PYH3_k127_7213185_17 NOG31153 non supervised orthologous group - - - 0.000001674 49.0
PYH3_k127_7213185_2 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 600.0
PYH3_k127_7213185_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 543.0
PYH3_k127_7213185_4 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 473.0
PYH3_k127_7213185_5 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 467.0
PYH3_k127_7213185_6 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 409.0
PYH3_k127_7213185_7 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 317.0
PYH3_k127_7213185_8 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 289.0
PYH3_k127_7213185_9 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000004162 254.0
PYH3_k127_7453015_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1252.0
PYH3_k127_7453015_1 amine dehydrogenase activity K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 461.0
PYH3_k127_7453015_2 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 308.0
PYH3_k127_7453015_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 293.0
PYH3_k127_7453015_4 protein conserved in archaea K09746 - - 0.00000000000000000000000000001068 128.0
PYH3_k127_7464525_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 9.954e-253 787.0
PYH3_k127_7464525_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.773e-242 757.0
PYH3_k127_7464525_10 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 417.0
PYH3_k127_7464525_11 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 377.0
PYH3_k127_7464525_12 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 363.0
PYH3_k127_7464525_13 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 365.0
PYH3_k127_7464525_14 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 360.0
PYH3_k127_7464525_15 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 355.0
PYH3_k127_7464525_16 Uncharacterised conserved protein (DUF2156) K01163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
PYH3_k127_7464525_17 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 325.0
PYH3_k127_7464525_18 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 296.0
PYH3_k127_7464525_19 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003188 269.0
PYH3_k127_7464525_2 AMP-binding enzyme - - - 5.783e-211 664.0
PYH3_k127_7464525_20 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009365 263.0
PYH3_k127_7464525_21 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001375 254.0
PYH3_k127_7464525_22 COG2041 Sulfite oxidase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006221 264.0
PYH3_k127_7464525_23 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004786 244.0
PYH3_k127_7464525_24 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006486 242.0
PYH3_k127_7464525_25 Integral membrane protein DUF106 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001335 241.0
PYH3_k127_7464525_26 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000021 238.0
PYH3_k127_7464525_27 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003085 252.0
PYH3_k127_7464525_28 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000004074 237.0
PYH3_k127_7464525_29 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000006829 233.0
PYH3_k127_7464525_3 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 9.391e-196 613.0
PYH3_k127_7464525_30 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000000008799 232.0
PYH3_k127_7464525_31 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000001459 228.0
PYH3_k127_7464525_32 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000000000000000005475 222.0
PYH3_k127_7464525_33 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000008358 217.0
PYH3_k127_7464525_34 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000003935 217.0
PYH3_k127_7464525_35 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000001059 209.0
PYH3_k127_7464525_36 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000007598 195.0
PYH3_k127_7464525_37 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000000000000000004129 185.0
PYH3_k127_7464525_38 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000005482 181.0
PYH3_k127_7464525_39 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000001945 175.0
PYH3_k127_7464525_4 PFAM Radical SAM domain protein K06871 - - 1.729e-195 614.0
PYH3_k127_7464525_40 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000003152 170.0
PYH3_k127_7464525_41 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.00000000000000000000000000000000000000000003716 163.0
PYH3_k127_7464525_42 PFAM Ribosomal protein K02912 - - 0.000000000000000000000000000000000000000007036 157.0
PYH3_k127_7464525_43 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.00000000000000000000000000003432 118.0
PYH3_k127_7464525_44 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000000000002581 106.0
PYH3_k127_7464525_45 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.0000000000000000000000008072 104.0
PYH3_k127_7464525_46 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000000000002181 105.0
PYH3_k127_7464525_47 PBS lyase HEAT-like repeat - - - 0.0000000000000178 80.0
PYH3_k127_7464525_48 - - - - 0.000404 47.0
PYH3_k127_7464525_5 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 588.0
PYH3_k127_7464525_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 536.0
PYH3_k127_7464525_7 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 486.0
PYH3_k127_7464525_8 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 476.0
PYH3_k127_7464525_9 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 454.0
PYH3_k127_7541500_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0 1261.0
PYH3_k127_7541500_1 PFAM amino acid permease-associated region K20265 - - 6.798e-213 669.0
PYH3_k127_7541500_2 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 604.0
PYH3_k127_7541500_3 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 415.0
PYH3_k127_7541500_4 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 337.0
PYH3_k127_7541500_5 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 309.0
PYH3_k127_7541500_6 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000476 216.0
PYH3_k127_7629518_0 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000003047 147.0
PYH3_k127_7629518_1 - - - - 0.00000000000000000000000000000000000007047 159.0
PYH3_k127_7629518_2 Outer membrane receptor - - - 0.00000004834 65.0
PYH3_k127_7822983_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1201.0
PYH3_k127_7822983_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.681e-208 662.0
PYH3_k127_7822983_10 2TM domain - - - 0.00000000000004039 76.0
PYH3_k127_7822983_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 7.696e-206 647.0
PYH3_k127_7822983_3 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 355.0
PYH3_k127_7822983_4 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 354.0
PYH3_k127_7822983_5 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 336.0
PYH3_k127_7822983_6 binding domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002531 275.0
PYH3_k127_7822983_7 META domain - - - 0.0000000000000000000000000000000000001092 153.0
PYH3_k127_7822983_8 META domain - - - 0.000000000000000000000000000000001259 140.0
PYH3_k127_7822983_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000001777 122.0
PYH3_k127_8094363_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.051e-317 980.0
PYH3_k127_8094363_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 6.773e-299 936.0
PYH3_k127_8094363_10 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 460.0
PYH3_k127_8094363_11 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 456.0
PYH3_k127_8094363_12 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 450.0
PYH3_k127_8094363_13 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
PYH3_k127_8094363_14 Membrane protein of unknown function DUF63 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 364.0
PYH3_k127_8094363_15 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 356.0
PYH3_k127_8094363_16 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 340.0
PYH3_k127_8094363_17 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 297.0
PYH3_k127_8094363_18 PFAM ADP-ribosylation Crystallin J1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 292.0
PYH3_k127_8094363_19 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000009281 254.0
PYH3_k127_8094363_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.27e-246 765.0
PYH3_k127_8094363_20 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000003966 245.0
PYH3_k127_8094363_21 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000001246 230.0
PYH3_k127_8094363_22 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000000002884 214.0
PYH3_k127_8094363_23 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000007036 211.0
PYH3_k127_8094363_24 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000000001225 186.0
PYH3_k127_8094363_25 - - - - 0.00000000000000000000000000000000000000000000000004183 182.0
PYH3_k127_8094363_26 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000000000000003847 186.0
PYH3_k127_8094363_27 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000000000000000002536 179.0
PYH3_k127_8094363_28 B-block binding subunit of TFIIIC - - - 0.00000000000000000000000000000000000000000000001226 174.0
PYH3_k127_8094363_29 tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001538 170.0
PYH3_k127_8094363_3 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 1.066e-235 739.0
PYH3_k127_8094363_30 PFAM Yip1 domain - - - 0.0000000000000000000000000000000000008296 146.0
PYH3_k127_8094363_31 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000000002832 135.0
PYH3_k127_8094363_32 - - - - 0.0000000000000000000000000000000001836 134.0
PYH3_k127_8094363_33 TfuA-like protein - - - 0.0000000000000000000000000000000003825 140.0
PYH3_k127_8094363_34 metal-binding protein - - - 0.0000000000000000000000000001148 117.0
PYH3_k127_8094363_35 COG0237 Dephospho-CoA kinase - - - 0.00000000000000000000004324 106.0
PYH3_k127_8094363_36 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000001421 101.0
PYH3_k127_8094363_37 - - - - 0.0000000000000000000001919 99.0
PYH3_k127_8094363_38 PFAM Ribosomal protein S27E K02978 - - 0.000000000000000000007235 97.0
PYH3_k127_8094363_39 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000001636 88.0
PYH3_k127_8094363_4 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.197e-231 723.0
PYH3_k127_8094363_40 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000003447 76.0
PYH3_k127_8094363_41 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000001146 59.0
PYH3_k127_8094363_5 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 6.324e-206 644.0
PYH3_k127_8094363_6 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009531 584.0
PYH3_k127_8094363_7 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 563.0
PYH3_k127_8094363_8 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 528.0
PYH3_k127_8094363_9 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 522.0
PYH3_k127_829371_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 581.0
PYH3_k127_829371_1 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 584.0
PYH3_k127_829371_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007488 342.0
PYH3_k127_829371_3 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001484 269.0
PYH3_k127_829371_4 - - - - 0.0005491 44.0
PYH3_k127_829371_5 NODP K20996 GO:0000139,GO:0000902,GO:0000904,GO:0001525,GO:0001568,GO:0001569,GO:0001709,GO:0001763,GO:0001885,GO:0001886,GO:0001944,GO:0002009,GO:0002064,GO:0002376,GO:0002520,GO:0003158,GO:0003382,GO:0003674,GO:0005102,GO:0005112,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006357,GO:0006366,GO:0006367,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007219,GO:0007221,GO:0007275,GO:0008150,GO:0008152,GO:0008593,GO:0009058,GO:0009059,GO:0009653,GO:0009888,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022603,GO:0023051,GO:0023052,GO:0023057,GO:0030097,GO:0030154,GO:0030162,GO:0030855,GO:0030856,GO:0030857,GO:0030879,GO:0031090,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032774,GO:0032879,GO:0032880,GO:0032989,GO:0034641,GO:0034645,GO:0034654,GO:0035239,GO:0035295,GO:0038023,GO:0042175,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045165,GO:0045446,GO:0045595,GO:0045596,GO:0045601,GO:0045602,GO:0045746,GO:0045765,GO:0045766,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0046872,GO:0046982,GO:0046983,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048646,GO:0048729,GO:0048731,GO:0048732,GO:0048754,GO:0048845,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051094,GO:0051171,GO:0051173,GO:0051239,GO:0051240,GO:0051246,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0060429,GO:0060562,GO:0060841,GO:0061138,GO:0065007,GO:0070013,GO:0070613,GO:0071704,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0080090,GO:0090304,GO:0097659,GO:0097708,GO:0098588,GO:0098791,GO:0098827,GO:1901342,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903317,GO:1903506,GO:1903508,GO:1903847,GO:1903849,GO:1904018,GO:1905651,GO:1905653,GO:2000026,GO:2000112,GO:2001141 - 0.0008573 46.0
PYH3_k127_8335829_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.942e-265 830.0
PYH3_k127_8335829_1 Predicted membrane protein (DUF2070) K08979 - - 7.917e-205 652.0
PYH3_k127_8335829_10 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 437.0
PYH3_k127_8335829_11 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 417.0
PYH3_k127_8335829_12 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 389.0
PYH3_k127_8335829_13 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 384.0
PYH3_k127_8335829_14 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005886 377.0
PYH3_k127_8335829_15 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 372.0
PYH3_k127_8335829_16 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 323.0
PYH3_k127_8335829_17 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 284.0
PYH3_k127_8335829_18 methanogen marker protein 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001645 274.0
PYH3_k127_8335829_19 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009959 272.0
PYH3_k127_8335829_2 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 608.0
PYH3_k127_8335829_20 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001398 274.0
PYH3_k127_8335829_21 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004267 280.0
PYH3_k127_8335829_22 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001239 270.0
PYH3_k127_8335829_23 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004169 267.0
PYH3_k127_8335829_24 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001278 237.0
PYH3_k127_8335829_25 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000528 204.0
PYH3_k127_8335829_26 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000000000000000000007978 190.0
PYH3_k127_8335829_27 Pas domain - - - 0.00000000000000000000000000000000000000000000000000005001 213.0
PYH3_k127_8335829_28 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000000005464 164.0
PYH3_k127_8335829_29 Pas domain - - - 0.0000000000000000000000000000000000001049 164.0
PYH3_k127_8335829_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 609.0
PYH3_k127_8335829_30 transcription factor (CBF NF-Y) - - - 0.000000000000000000000000002823 114.0
PYH3_k127_8335829_31 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000003905 121.0
PYH3_k127_8335829_32 Family of unknown function (DUF5350) - - - 0.000000000000000000000002727 105.0
PYH3_k127_8335829_33 PFAM TPR repeat-containing protein - - - 0.0000000000000000000007972 98.0
PYH3_k127_8335829_34 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000008994 82.0
PYH3_k127_8335829_35 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0001312 50.0
PYH3_k127_8335829_4 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 587.0
PYH3_k127_8335829_5 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 553.0
PYH3_k127_8335829_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 526.0
PYH3_k127_8335829_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 504.0
PYH3_k127_8335829_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007341 466.0
PYH3_k127_8335829_9 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 458.0
PYH3_k127_8470186_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 4.311e-264 818.0
PYH3_k127_8470186_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.417e-227 710.0
PYH3_k127_8470186_10 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 346.0
PYH3_k127_8470186_11 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 315.0
PYH3_k127_8470186_12 NAD(P)H dehydrogenase (quinone) activity K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009361 308.0
PYH3_k127_8470186_13 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 300.0
PYH3_k127_8470186_14 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 296.0
PYH3_k127_8470186_15 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 293.0
PYH3_k127_8470186_16 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000000000000000000000000000000000000000000001511 255.0
PYH3_k127_8470186_17 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000000000000000000000000000000001323 238.0
PYH3_k127_8470186_18 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000008763 235.0
PYH3_k127_8470186_19 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000001037 221.0
PYH3_k127_8470186_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 2.574e-224 713.0
PYH3_k127_8470186_20 archaeal Zn-finger protein - - - 0.000000000000000000000000000000000000000000000000000000000003136 214.0
PYH3_k127_8470186_21 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000000000000000000000000000000004101 220.0
PYH3_k127_8470186_22 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000005101 209.0
PYH3_k127_8470186_23 Flavodoxin - - - 0.0000000000000000000000000000000000000000000000000001358 190.0
PYH3_k127_8470186_24 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000004783 182.0
PYH3_k127_8470186_25 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000000002543 176.0
PYH3_k127_8470186_26 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000000000003112 171.0
PYH3_k127_8470186_27 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000000003396 171.0
PYH3_k127_8470186_28 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000007592 153.0
PYH3_k127_8470186_29 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000003406 152.0
PYH3_k127_8470186_3 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 6.406e-196 617.0
PYH3_k127_8470186_30 DNA polymerase activity K02319 - 2.7.7.7 0.000000000000000000000000000000000002766 145.0
PYH3_k127_8470186_31 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000003097 137.0
PYH3_k127_8470186_32 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000000001048 127.0
PYH3_k127_8470186_33 - - - - 0.000000000000000000000000008502 119.0
PYH3_k127_8470186_34 - - - - 0.0000000000000000000000003782 116.0
PYH3_k127_8470186_35 Proline dehydrogenase K00318 GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.000000000000000000000004718 112.0
PYH3_k127_8470186_36 CRS1_YhbY K07574 - - 0.0000000000000000000001528 99.0
PYH3_k127_8470186_37 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000003638 92.0
PYH3_k127_8470186_38 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000009148 87.0
PYH3_k127_8470186_39 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000002144 85.0
PYH3_k127_8470186_4 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.023e-194 614.0
PYH3_k127_8470186_41 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000007725 64.0
PYH3_k127_8470186_42 - - - - 0.00000000188 63.0
PYH3_k127_8470186_43 - - - - 0.000000003015 58.0
PYH3_k127_8470186_44 - - - - 0.000000005114 58.0
PYH3_k127_8470186_45 - - - - 0.0000009195 60.0
PYH3_k127_8470186_46 - - - - 0.000001569 58.0
PYH3_k127_8470186_5 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 544.0
PYH3_k127_8470186_6 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 542.0
PYH3_k127_8470186_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 466.0
PYH3_k127_8470186_8 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 470.0
PYH3_k127_8470186_9 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 420.0
PYH3_k127_8674608_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1196.0
PYH3_k127_8674608_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 1.092e-242 762.0
PYH3_k127_8674608_10 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 494.0
PYH3_k127_8674608_11 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 444.0
PYH3_k127_8674608_12 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 420.0
PYH3_k127_8674608_13 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 411.0
PYH3_k127_8674608_14 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 366.0
PYH3_k127_8674608_15 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 368.0
PYH3_k127_8674608_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 347.0
PYH3_k127_8674608_17 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 338.0
PYH3_k127_8674608_18 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 314.0
PYH3_k127_8674608_19 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 301.0
PYH3_k127_8674608_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.162e-209 661.0
PYH3_k127_8674608_20 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001832 284.0
PYH3_k127_8674608_21 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002727 254.0
PYH3_k127_8674608_22 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000329 236.0
PYH3_k127_8674608_23 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000008434 216.0
PYH3_k127_8674608_24 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000001811 145.0
PYH3_k127_8674608_25 - - - - 0.000000000000000000000000000000000007241 138.0
PYH3_k127_8674608_26 Peptidyl-prolyl cis-trans K01802,K03768,K03775 - 5.2.1.8 0.000000000000000000000000000000007516 136.0
PYH3_k127_8674608_27 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.00000000000000000266 84.0
PYH3_k127_8674608_28 - - - - 0.000000000000000004665 89.0
PYH3_k127_8674608_29 - - - - 0.0000000000001994 72.0
PYH3_k127_8674608_3 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 4.033e-204 641.0
PYH3_k127_8674608_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 2.571e-194 611.0
PYH3_k127_8674608_5 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 598.0
PYH3_k127_8674608_6 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 562.0
PYH3_k127_8674608_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 557.0
PYH3_k127_8674608_8 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 525.0
PYH3_k127_8674608_9 CoB--CoM heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 520.0
PYH3_k127_8692795_0 DEAD DEAH box helicase K06877 - - 6.115e-282 885.0
PYH3_k127_8692795_1 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 461.0
PYH3_k127_8692795_2 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 390.0
PYH3_k127_8692795_3 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 383.0
PYH3_k127_8692795_4 PFAM Linocin_M18 bacteriocin protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 323.0
PYH3_k127_8692795_5 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 294.0
PYH3_k127_8692795_6 Rubrerythrin - - - 0.0000000000005864 70.0
PYH3_k127_8720333_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.957e-298 923.0
PYH3_k127_8720333_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.317e-258 801.0
PYH3_k127_8720333_10 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 453.0
PYH3_k127_8720333_11 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 450.0
PYH3_k127_8720333_12 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 426.0
PYH3_k127_8720333_13 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 425.0
PYH3_k127_8720333_14 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 417.0
PYH3_k127_8720333_15 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 401.0
PYH3_k127_8720333_16 Branched-chain amino acid transport system permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 385.0
PYH3_k127_8720333_17 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 379.0
PYH3_k127_8720333_18 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 375.0
PYH3_k127_8720333_19 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 362.0
PYH3_k127_8720333_2 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 8.174e-255 803.0
PYH3_k127_8720333_20 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 357.0
PYH3_k127_8720333_21 V-type ATP synthase, subunit I K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 352.0
PYH3_k127_8720333_22 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 322.0
PYH3_k127_8720333_23 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 321.0
PYH3_k127_8720333_24 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 306.0
PYH3_k127_8720333_25 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 308.0
PYH3_k127_8720333_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 314.0
PYH3_k127_8720333_27 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 307.0
PYH3_k127_8720333_28 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 299.0
PYH3_k127_8720333_29 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 297.0
PYH3_k127_8720333_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.437e-245 769.0
PYH3_k127_8720333_30 FHA domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 294.0
PYH3_k127_8720333_31 archaeosine synthase activity K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 286.0
PYH3_k127_8720333_32 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000342 290.0
PYH3_k127_8720333_33 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000101 267.0
PYH3_k127_8720333_34 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003653 263.0
PYH3_k127_8720333_35 PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001721 261.0
PYH3_k127_8720333_36 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
PYH3_k127_8720333_37 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004171 241.0
PYH3_k127_8720333_38 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000004855 231.0
PYH3_k127_8720333_39 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000000000000002234 242.0
PYH3_k127_8720333_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 1.18e-208 656.0
PYH3_k127_8720333_40 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000000000000000000005207 231.0
PYH3_k127_8720333_41 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000006552 214.0
PYH3_k127_8720333_42 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000005863 214.0
PYH3_k127_8720333_43 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000001242 192.0
PYH3_k127_8720333_44 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000001353 190.0
PYH3_k127_8720333_45 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000002668 184.0
PYH3_k127_8720333_46 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000008925 188.0
PYH3_k127_8720333_47 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000000000000001654 175.0
PYH3_k127_8720333_48 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000004114 167.0
PYH3_k127_8720333_49 ATP synthase subunit K K02124 - - 0.00000000000000000000000000000000000000000001906 165.0
PYH3_k127_8720333_5 V-type ATPase 116kDa subunit family K02123 - - 9.022e-199 638.0
PYH3_k127_8720333_50 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000006529 169.0
PYH3_k127_8720333_51 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000000007358 157.0
PYH3_k127_8720333_52 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000197 138.0
PYH3_k127_8720333_53 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000001722 123.0
PYH3_k127_8720333_54 Phosphate-starvation-inducible E - - - 0.0000000000000000000000000006838 117.0
PYH3_k127_8720333_55 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000145 120.0
PYH3_k127_8720333_56 PFAM GCN5-related N-acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.000000000000000000000000001718 117.0
PYH3_k127_8720333_57 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000003618 120.0
PYH3_k127_8720333_58 Universal stress protein family - - - 0.00000000000000000000000001185 116.0
PYH3_k127_8720333_59 Protein of unknown function (DUF3344) - - - 0.00000000000000000000000002067 124.0
PYH3_k127_8720333_6 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 6.212e-197 623.0
PYH3_k127_8720333_60 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000005773 109.0
PYH3_k127_8720333_61 ATP synthase subunit C K02124 - - 0.00000000000000000000007405 99.0
PYH3_k127_8720333_62 ATP synthase subunit C K02124 - - 0.00000000000000000000653 94.0
PYH3_k127_8720333_63 Protein of unknown function (DUF2764) - - - 0.000000000000000000007119 98.0
PYH3_k127_8720333_64 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000005921 90.0
PYH3_k127_8720333_65 metallopeptidase activity - - - 0.000000000000000004379 98.0
PYH3_k127_8720333_66 membrane transporter protein K07090 - - 0.000000000000000004604 91.0
PYH3_k127_8720333_67 - K01448 - 3.5.1.28 0.0000000000000002477 81.0
PYH3_k127_8720333_68 - - - - 0.000000000000001152 85.0
PYH3_k127_8720333_7 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 556.0
PYH3_k127_8720333_70 PFAM Protein kinase domain - - - 0.000000000000007394 83.0
PYH3_k127_8720333_72 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000002886 77.0
PYH3_k127_8720333_73 membrane transporter protein K07090 - - 0.0000000001396 70.0
PYH3_k127_8720333_74 S-layer homology domain - - - 0.000000009942 69.0
PYH3_k127_8720333_75 COG1520 FOG WD40-like repeat - - - 0.00000002999 59.0
PYH3_k127_8720333_76 helicase C-terminal domain protein - - - 0.0000002585 61.0
PYH3_k127_8720333_77 H subunit K02107 - - 0.0000264 51.0
PYH3_k127_8720333_8 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 552.0
PYH3_k127_8720333_9 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 458.0
PYH3_k127_8768378_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1148.0
PYH3_k127_8768378_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 4.5e-303 954.0
PYH3_k127_8768378_10 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 1.638e-194 613.0
PYH3_k127_8768378_100 PFAM PKD domain containing protein - - - 0.000000000000000001789 96.0
PYH3_k127_8768378_101 PFAM Uncharacterised conserved protein UCP006577 - - - 0.00000000000000001965 85.0
PYH3_k127_8768378_103 - - - - 0.0000000000000906 76.0
PYH3_k127_8768378_104 TPR repeat Sel1-like repeat Tetratricopeptide TPR_3 Tetratricopeptide TPR_2 - - - 0.00002851 55.0
PYH3_k127_8768378_11 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 607.0
PYH3_k127_8768378_12 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 602.0
PYH3_k127_8768378_13 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 596.0
PYH3_k127_8768378_14 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 595.0
PYH3_k127_8768378_15 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 567.0
PYH3_k127_8768378_16 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 552.0
PYH3_k127_8768378_17 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 527.0
PYH3_k127_8768378_18 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 526.0
PYH3_k127_8768378_19 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007714 526.0
PYH3_k127_8768378_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.722e-271 842.0
PYH3_k127_8768378_20 PFAM DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 511.0
PYH3_k127_8768378_21 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 498.0
PYH3_k127_8768378_22 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 460.0
PYH3_k127_8768378_23 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 467.0
PYH3_k127_8768378_24 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 428.0
PYH3_k127_8768378_25 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 428.0
PYH3_k127_8768378_26 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 422.0
PYH3_k127_8768378_27 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 422.0
PYH3_k127_8768378_28 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005496 431.0
PYH3_k127_8768378_29 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 401.0
PYH3_k127_8768378_3 amino acid K03294 - - 6.206e-266 834.0
PYH3_k127_8768378_30 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 391.0
PYH3_k127_8768378_31 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 392.0
PYH3_k127_8768378_32 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 368.0
PYH3_k127_8768378_33 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 365.0
PYH3_k127_8768378_34 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 367.0
PYH3_k127_8768378_35 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009152 352.0
PYH3_k127_8768378_36 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 339.0
PYH3_k127_8768378_37 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
PYH3_k127_8768378_38 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 353.0
PYH3_k127_8768378_39 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 338.0
PYH3_k127_8768378_4 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 2.92e-257 801.0
PYH3_k127_8768378_40 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 331.0
PYH3_k127_8768378_41 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 323.0
PYH3_k127_8768378_42 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 311.0
PYH3_k127_8768378_43 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 294.0
PYH3_k127_8768378_44 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 288.0
PYH3_k127_8768378_45 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000216 272.0
PYH3_k127_8768378_46 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005282 274.0
PYH3_k127_8768378_47 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001084 270.0
PYH3_k127_8768378_48 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002708 271.0
PYH3_k127_8768378_49 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000001474 267.0
PYH3_k127_8768378_5 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 2.873e-250 783.0
PYH3_k127_8768378_50 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000016 259.0
PYH3_k127_8768378_51 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003087 254.0
PYH3_k127_8768378_52 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18023 - 1.12.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006562 251.0
PYH3_k127_8768378_53 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001297 250.0
PYH3_k127_8768378_54 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001079 245.0
PYH3_k127_8768378_55 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000001277 244.0
PYH3_k127_8768378_56 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002397 241.0
PYH3_k127_8768378_57 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000004489 242.0
PYH3_k127_8768378_58 Domain of unknown function (DUF1724) - - - 0.00000000000000000000000000000000000000000000000000000000000000001005 233.0
PYH3_k127_8768378_59 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000001057 231.0
PYH3_k127_8768378_6 Highly conserved protein containing a thioredoxin domain K06888 - - 2.381e-210 675.0
PYH3_k127_8768378_60 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000000001611 226.0
PYH3_k127_8768378_61 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000003122 226.0
PYH3_k127_8768378_62 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000304 220.0
PYH3_k127_8768378_63 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000000000000736 218.0
PYH3_k127_8768378_64 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.000000000000000000000000000000000000000000000000000000000003006 214.0
PYH3_k127_8768378_65 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000005132 208.0
PYH3_k127_8768378_66 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.000000000000000000000000000000000000000000000000000000006604 200.0
PYH3_k127_8768378_67 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000386 202.0
PYH3_k127_8768378_68 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000006969 196.0
PYH3_k127_8768378_69 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000001098 206.0
PYH3_k127_8768378_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 7.536e-199 626.0
PYH3_k127_8768378_70 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000007272 193.0
PYH3_k127_8768378_71 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000009626 201.0
PYH3_k127_8768378_72 Small multi-drug export protein - - - 0.0000000000000000000000000000000000000000000000000001017 194.0
PYH3_k127_8768378_73 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000000000000000000000000002347 184.0
PYH3_k127_8768378_74 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000201 179.0
PYH3_k127_8768378_75 NTPase - - - 0.0000000000000000000000000000000000000000000000002458 181.0
PYH3_k127_8768378_76 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000641 179.0
PYH3_k127_8768378_77 Cupin domain - - - 0.00000000000000000000000000000000000000000000001601 181.0
PYH3_k127_8768378_78 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.00000000000000000000000000000000000000000000002326 177.0
PYH3_k127_8768378_79 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000004093 161.0
PYH3_k127_8768378_8 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 1.577e-198 632.0
PYH3_k127_8768378_80 - - - - 0.0000000000000000000000000000000000000000004095 166.0
PYH3_k127_8768378_81 Belongs to the UPF0216 family K09737 - - 0.000000000000000000000000000000000000000004181 162.0
PYH3_k127_8768378_82 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000003132 156.0
PYH3_k127_8768378_83 - - - - 0.0000000000000000000000000000000000000006704 151.0
PYH3_k127_8768378_84 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000000000000000000372 149.0
PYH3_k127_8768378_85 Hydrogenase maturation protease K08315 - 3.4.23.51 0.0000000000000000000000000000000000003495 147.0
PYH3_k127_8768378_86 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000007721 145.0
PYH3_k127_8768378_87 - - - - 0.000000000000000000000000000000000001886 143.0
PYH3_k127_8768378_88 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000004319 149.0
PYH3_k127_8768378_89 Cobalamin biosynthesis protein CbiG K02189 - 3.7.1.12 0.000000000000000000000000000000000007844 147.0
PYH3_k127_8768378_9 Proton-conducting membrane transporter K05568 - - 4.607e-195 616.0
PYH3_k127_8768378_90 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000002032 137.0
PYH3_k127_8768378_91 small multi-drug export - - - 0.00000000000000000000000000000002132 133.0
PYH3_k127_8768378_92 - - - - 0.0000000000000000000000000000001377 129.0
PYH3_k127_8768378_93 - - - - 0.000000000000000000000000000001473 124.0
PYH3_k127_8768378_94 Beta-propeller repeat - - - 0.0000000000000000000000000006985 116.0
PYH3_k127_8768378_95 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000000001355 113.0
PYH3_k127_8768378_96 - - - - 0.00000000000000000000000002473 115.0
PYH3_k127_8768378_97 META domain - - - 0.00000000000000000000000005901 112.0
PYH3_k127_8768378_98 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000002832 108.0
PYH3_k127_8768378_99 - - - - 0.000000000000000000000002585 104.0
PYH3_k127_8768819_0 Belongs to the glutamate synthase family - - - 1.766e-219 691.0
PYH3_k127_8768819_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 420.0
PYH3_k127_8768819_10 - - - - 0.00000000000001863 74.0
PYH3_k127_8768819_11 PFAM YHS domain - - - 0.00000000001573 72.0
PYH3_k127_8768819_2 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 384.0
PYH3_k127_8768819_3 PFAM zinc iron permease K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 347.0
PYH3_k127_8768819_4 PFAM Ferritin, Dps family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 317.0
PYH3_k127_8768819_5 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 302.0
PYH3_k127_8768819_6 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000004041 214.0
PYH3_k127_8768819_7 - - - - 0.00000000000000000000000000004203 127.0
PYH3_k127_8768819_8 peptide deformylase activity K01462 - 3.5.1.88 0.00000000000000000000000000009984 123.0
PYH3_k127_8768819_9 Protein of unknown function (DUF2769) - - - 0.000000000000000001545 94.0
PYH3_k127_899845_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 2.808e-298 928.0
PYH3_k127_899845_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.585e-284 890.0
PYH3_k127_899845_10 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 612.0
PYH3_k127_899845_11 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 585.0
PYH3_k127_899845_12 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 584.0
PYH3_k127_899845_13 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 590.0
PYH3_k127_899845_14 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 568.0
PYH3_k127_899845_15 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 570.0
PYH3_k127_899845_16 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 547.0
PYH3_k127_899845_17 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 544.0
PYH3_k127_899845_18 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 529.0
PYH3_k127_899845_19 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 520.0
PYH3_k127_899845_2 PFAM ABC transporter K00400 - - 2.718e-281 871.0
PYH3_k127_899845_20 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 493.0
PYH3_k127_899845_21 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 478.0
PYH3_k127_899845_22 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 476.0
PYH3_k127_899845_23 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 463.0
PYH3_k127_899845_24 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 479.0
PYH3_k127_899845_25 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 464.0
PYH3_k127_899845_26 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008904 445.0
PYH3_k127_899845_27 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 415.0
PYH3_k127_899845_28 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 407.0
PYH3_k127_899845_29 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 410.0
PYH3_k127_899845_3 SMART Elongator protein 3 MiaB NifB - - - 3.19e-260 814.0
PYH3_k127_899845_30 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 380.0
PYH3_k127_899845_31 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 374.0
PYH3_k127_899845_32 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 366.0
PYH3_k127_899845_33 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 360.0
PYH3_k127_899845_34 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 340.0
PYH3_k127_899845_35 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 338.0
PYH3_k127_899845_36 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
PYH3_k127_899845_37 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 329.0
PYH3_k127_899845_38 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 325.0
PYH3_k127_899845_39 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 316.0
PYH3_k127_899845_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.102e-254 788.0
PYH3_k127_899845_40 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 311.0
PYH3_k127_899845_41 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 290.0
PYH3_k127_899845_42 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 310.0
PYH3_k127_899845_43 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 282.0
PYH3_k127_899845_44 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000101 281.0
PYH3_k127_899845_45 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002076 278.0
PYH3_k127_899845_46 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
PYH3_k127_899845_47 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000362 269.0
PYH3_k127_899845_48 O-methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005082 270.0
PYH3_k127_899845_49 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001809 271.0
PYH3_k127_899845_5 Involved in regulation of DNA replication K10725 - - 9.512e-219 685.0
PYH3_k127_899845_50 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000002131 271.0
PYH3_k127_899845_51 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002634 267.0
PYH3_k127_899845_52 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008031 267.0
PYH3_k127_899845_53 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000001605 264.0
PYH3_k127_899845_54 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
PYH3_k127_899845_55 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005644 248.0
PYH3_k127_899845_56 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000007568 238.0
PYH3_k127_899845_57 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000001594 238.0
PYH3_k127_899845_58 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001532 236.0
PYH3_k127_899845_59 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002725 233.0
PYH3_k127_899845_6 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.22e-216 677.0
PYH3_k127_899845_60 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002081 232.0
PYH3_k127_899845_61 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000002456 227.0
PYH3_k127_899845_62 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000000000000001345 215.0
PYH3_k127_899845_63 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000003464 217.0
PYH3_k127_899845_64 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000001401 210.0
PYH3_k127_899845_65 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000007345 202.0
PYH3_k127_899845_66 - - - - 0.00000000000000000000000000000000000000000000000000000002434 209.0
PYH3_k127_899845_67 PFAM response regulator receiveR - - - 0.000000000000000000000000000000000000000000000000007439 185.0
PYH3_k127_899845_68 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000005411 186.0
PYH3_k127_899845_69 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000001119 179.0
PYH3_k127_899845_7 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 3.123e-206 648.0
PYH3_k127_899845_70 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000001403 182.0
PYH3_k127_899845_71 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000000000000000000005892 173.0
PYH3_k127_899845_72 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001464 171.0
PYH3_k127_899845_73 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000015 175.0
PYH3_k127_899845_74 Yip1 domain - - - 0.000000000000000000000000000000000000000000043 169.0
PYH3_k127_899845_75 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000006108 164.0
PYH3_k127_899845_76 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000000007337 159.0
PYH3_k127_899845_77 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000004662 148.0
PYH3_k127_899845_78 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000005463 141.0
PYH3_k127_899845_79 Condensation domain - - - 0.0000000000000000000000000000000007568 146.0
PYH3_k127_899845_8 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 2.984e-204 644.0
PYH3_k127_899845_80 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.000000000000000000000000000000003049 138.0
PYH3_k127_899845_81 Domain of unknown function (DUF1805) - - - 0.000000000000000000000000000000131 126.0
PYH3_k127_899845_82 Transcriptional regulator K07729 - - 0.0000000000000000000000006156 107.0
PYH3_k127_899845_83 Trm112p-like protein - - - 0.000000000000000000505 87.0
PYH3_k127_899845_84 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000000000001753 66.0
PYH3_k127_899845_85 - - - - 0.000000004009 65.0
PYH3_k127_899845_86 - - - - 0.000000009875 63.0
PYH3_k127_899845_9 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 4.964e-195 618.0
PYH3_k127_9193062_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.424e-293 909.0
PYH3_k127_9193062_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.224e-285 884.0
PYH3_k127_9193062_10 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 540.0
PYH3_k127_9193062_11 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 501.0
PYH3_k127_9193062_12 Phosphate transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 512.0
PYH3_k127_9193062_13 PFAM Archaeal protein of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 497.0
PYH3_k127_9193062_14 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 476.0
PYH3_k127_9193062_15 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 429.0
PYH3_k127_9193062_16 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 424.0
PYH3_k127_9193062_17 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 380.0
PYH3_k127_9193062_18 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 380.0
PYH3_k127_9193062_19 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 373.0
PYH3_k127_9193062_2 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.311e-281 874.0
PYH3_k127_9193062_20 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 361.0
PYH3_k127_9193062_21 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 362.0
PYH3_k127_9193062_22 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 349.0
PYH3_k127_9193062_23 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 348.0
PYH3_k127_9193062_24 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 331.0
PYH3_k127_9193062_25 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 330.0
PYH3_k127_9193062_26 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 325.0
PYH3_k127_9193062_27 Tetratricopeptide repeat K12600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 343.0
PYH3_k127_9193062_28 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 306.0
PYH3_k127_9193062_29 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 303.0
PYH3_k127_9193062_3 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 4.598e-261 811.0
PYH3_k127_9193062_30 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 297.0
PYH3_k127_9193062_31 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
PYH3_k127_9193062_32 amino acid transport K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004286 272.0
PYH3_k127_9193062_33 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000005641 266.0
PYH3_k127_9193062_34 4Fe-4S dicluster domain K11260,K14107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006074 257.0
PYH3_k127_9193062_35 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001097 252.0
PYH3_k127_9193062_36 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001722 271.0
PYH3_k127_9193062_37 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002286 246.0
PYH3_k127_9193062_38 - K14093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003181 242.0
PYH3_k127_9193062_39 V4R K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
PYH3_k127_9193062_4 Protein of unknown function (DUF460) K09150 - - 2.724e-255 802.0
PYH3_k127_9193062_40 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000099 221.0
PYH3_k127_9193062_41 PFAM ABC transporter K16787 - - 0.0000000000000000000000000000000000000000000000000000000000005326 218.0
PYH3_k127_9193062_42 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000001519 220.0
PYH3_k127_9193062_43 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000001558 214.0
PYH3_k127_9193062_44 PFAM transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000002406 217.0
PYH3_k127_9193062_45 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000001296 212.0
PYH3_k127_9193062_46 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000000000006705 211.0
PYH3_k127_9193062_47 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000005321 200.0
PYH3_k127_9193062_48 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000005965 192.0
PYH3_k127_9193062_49 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000000000000000000368 188.0
PYH3_k127_9193062_5 Belongs to the RtcB family K14415 - 6.5.1.3 1.95e-228 715.0
PYH3_k127_9193062_50 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000002547 184.0
PYH3_k127_9193062_51 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.00000000000000000000000000000000000000000000000000646 185.0
PYH3_k127_9193062_52 - - - - 0.00000000000000000000000000000000000000000000007959 179.0
PYH3_k127_9193062_53 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000000000001302 171.0
PYH3_k127_9193062_54 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000000000000000006185 143.0
PYH3_k127_9193062_55 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000001252 138.0
PYH3_k127_9193062_56 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000001245 127.0
PYH3_k127_9193062_57 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000006901 128.0
PYH3_k127_9193062_58 - K00960 - 2.7.7.6 0.0000000000000000000000000003614 113.0
PYH3_k127_9193062_59 PFAM molydopterin dinucleotide-binding region K00201,K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.0000000000000000000000000006551 117.0
PYH3_k127_9193062_6 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 6.177e-211 665.0
PYH3_k127_9193062_60 Predicted membrane protein (DUF2109) K14094 - - 0.00000000000000000000000000165 115.0
PYH3_k127_9193062_61 - - - - 0.00000000000000000000000001339 108.0
PYH3_k127_9193062_62 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000001814 108.0
PYH3_k127_9193062_63 - - - - 0.000000000000000000000001316 106.0
PYH3_k127_9193062_64 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000000000000001842 101.0
PYH3_k127_9193062_65 Predicted membrane protein (DUF2107) K14096 - - 0.0000000000000000000003252 98.0
PYH3_k127_9193062_66 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.0000000000000000001779 94.0
PYH3_k127_9193062_67 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000001409 85.0
PYH3_k127_9193062_68 metallopeptidase activity - - - 0.0000000000001919 74.0
PYH3_k127_9193062_69 Predicted membrane protein (DUF2108) K14095 - - 0.000000000001084 72.0
PYH3_k127_9193062_7 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 8.499e-203 635.0
PYH3_k127_9193062_70 of cations and cationic drugs K11741 - - 0.0000000001112 64.0
PYH3_k127_9193062_71 - K14100 - - 0.000000004402 59.0
PYH3_k127_9193062_72 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000001928 60.0
PYH3_k127_9193062_74 - - - - 0.0000002297 59.0
PYH3_k127_9193062_75 Dinitrogenase iron-molybdenum cofactor - - - 0.000002986 50.0
PYH3_k127_9193062_76 Small Multidrug Resistance protein K11741 - - 0.000006093 48.0
PYH3_k127_9193062_77 - - - - 0.00003847 54.0
PYH3_k127_9193062_78 - - - - 0.0009765 48.0
PYH3_k127_9193062_8 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 598.0
PYH3_k127_9193062_9 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 557.0
PYH3_k127_9269123_0 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 5.12e-221 689.0
PYH3_k127_9269123_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000004763 83.0
PYH3_k127_9269123_2 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.000000000949 73.0
PYH3_k127_9269123_3 Nitric oxide reductase activation protein - - - 0.0003154 54.0
PYH3_k127_9377268_0 KH, type 1, domain K07041 - - 0.0 1133.0
PYH3_k127_9377268_1 in RNase L inhibitor, RLI K06174 - - 1.84e-301 932.0
PYH3_k127_9377268_10 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 299.0
PYH3_k127_9377268_11 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 297.0
PYH3_k127_9377268_12 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001249 257.0
PYH3_k127_9377268_13 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000001446 231.0
PYH3_k127_9377268_14 Zinc-uptake complex component A periplasmic K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000008015 231.0
PYH3_k127_9377268_15 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000417 218.0
PYH3_k127_9377268_16 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000002759 190.0
PYH3_k127_9377268_17 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000001518 172.0
PYH3_k127_9377268_18 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.000000000000000000000000000000000000000000001158 169.0
PYH3_k127_9377268_19 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000008047 164.0
PYH3_k127_9377268_2 Domain of unknown function (DUF814) - - - 2.203e-217 691.0
PYH3_k127_9377268_20 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000001281 164.0
PYH3_k127_9377268_21 - - - - 0.0000000000000000000000000000002815 126.0
PYH3_k127_9377268_22 RNase L inhibitor, RLI - - - 0.0000000000000000000000001692 109.0
PYH3_k127_9377268_23 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000002438 74.0
PYH3_k127_9377268_24 but it may be involved in stabilization of the trimeric complex - - - 0.0000000000007957 69.0
PYH3_k127_9377268_25 PKD domain containing protein - - - 0.000000000709 72.0
PYH3_k127_9377268_3 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 450.0
PYH3_k127_9377268_4 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 441.0
PYH3_k127_9377268_5 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 440.0
PYH3_k127_9377268_6 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 394.0
PYH3_k127_9377268_7 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 387.0
PYH3_k127_9377268_8 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
PYH3_k127_9377268_9 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 311.0
PYH3_k127_9424819_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1349.0
PYH3_k127_9424819_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.553e-250 785.0
PYH3_k127_9424819_10 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000000000000000000000000000000000000000003525 243.0
PYH3_k127_9424819_11 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000001543 226.0
PYH3_k127_9424819_12 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
PYH3_k127_9424819_13 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000001831 168.0
PYH3_k127_9424819_14 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000002324 134.0
PYH3_k127_9424819_15 - - - - 0.000000000000000000000000003183 112.0
PYH3_k127_9424819_16 - - - - 0.00000000000000000000003639 106.0
PYH3_k127_9424819_17 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000007935 99.0
PYH3_k127_9424819_18 - - - - 0.000000000000000001765 88.0
PYH3_k127_9424819_19 - - - - 0.0000000000179 68.0
PYH3_k127_9424819_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 3.759e-211 661.0
PYH3_k127_9424819_20 - - - - 0.0000001403 58.0
PYH3_k127_9424819_3 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 605.0
PYH3_k127_9424819_4 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 470.0
PYH3_k127_9424819_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 385.0
PYH3_k127_9424819_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 347.0
PYH3_k127_9424819_7 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 340.0
PYH3_k127_9424819_8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 321.0
PYH3_k127_9424819_9 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
PYH3_k127_9547736_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1520.0
PYH3_k127_9547736_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1167.0
PYH3_k127_9547736_10 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 565.0
PYH3_k127_9547736_11 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 546.0
PYH3_k127_9547736_12 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 514.0
PYH3_k127_9547736_13 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 510.0
PYH3_k127_9547736_14 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 501.0
PYH3_k127_9547736_15 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 473.0
PYH3_k127_9547736_16 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 439.0
PYH3_k127_9547736_17 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 433.0
PYH3_k127_9547736_18 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 432.0
PYH3_k127_9547736_19 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 422.0
PYH3_k127_9547736_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.232e-264 826.0
PYH3_k127_9547736_20 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 422.0
PYH3_k127_9547736_21 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 423.0
PYH3_k127_9547736_22 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 413.0
PYH3_k127_9547736_23 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 403.0
PYH3_k127_9547736_24 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 378.0
PYH3_k127_9547736_25 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 372.0
PYH3_k127_9547736_26 SPFH Band 7 PHB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 370.0
PYH3_k127_9547736_27 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006361 368.0
PYH3_k127_9547736_28 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 366.0
PYH3_k127_9547736_29 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 353.0
PYH3_k127_9547736_3 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 1.397e-246 775.0
PYH3_k127_9547736_30 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 340.0
PYH3_k127_9547736_31 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 306.0
PYH3_k127_9547736_32 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 301.0
PYH3_k127_9547736_33 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006707 280.0
PYH3_k127_9547736_34 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008812 283.0
PYH3_k127_9547736_35 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006101 257.0
PYH3_k127_9547736_36 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003403 253.0
PYH3_k127_9547736_37 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000001004 222.0
PYH3_k127_9547736_38 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.000000000000000000000000000000000000000000000000000000000004742 212.0
PYH3_k127_9547736_39 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000004759 190.0
PYH3_k127_9547736_4 SMART Elongator protein 3 MiaB NifB - - - 2.237e-238 747.0
PYH3_k127_9547736_40 positive regulation of acetylcholine metabolic process K06910 - - 0.000000000000000000000000000000000000000000000000003472 186.0
PYH3_k127_9547736_41 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000004379 188.0
PYH3_k127_9547736_42 PFAM RDD domain containing protein - - - 0.0000000000000000000000000000000000000000007455 162.0
PYH3_k127_9547736_43 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000009351 164.0
PYH3_k127_9547736_44 membrane protein domain - - - 0.00000000000000000000000000000000000000002089 160.0
PYH3_k127_9547736_45 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000002457 156.0
PYH3_k127_9547736_46 - - - - 0.0000000000000000000000000000000000001042 149.0
PYH3_k127_9547736_47 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000006937 130.0
PYH3_k127_9547736_48 PFAM PRC-barrel domain - - - 0.000000000000000000000000000002019 122.0
PYH3_k127_9547736_49 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000001973 91.0
PYH3_k127_9547736_5 AAA-like domain K06915 - - 6.201e-236 740.0
PYH3_k127_9547736_50 - - - - 0.000000000000000002679 85.0
PYH3_k127_9547736_52 - K03686 - - 0.000000000000001269 79.0
PYH3_k127_9547736_53 - K06868 - 2.5.1.73 0.0000000000009565 69.0
PYH3_k127_9547736_54 methanogen marker protein 4 - - - 0.000000000001324 72.0
PYH3_k127_9547736_6 phosphoesterase RecJ domain protein - - - 2.096e-202 641.0
PYH3_k127_9547736_7 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.131e-198 623.0
PYH3_k127_9547736_8 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 576.0
PYH3_k127_9547736_9 PFAM Aldehyde dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 569.0
PYH3_k127_9625811_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0 1144.0
PYH3_k127_9625811_1 Bacterial protein of unknown function (DUF853) K06915 - - 3.255e-196 623.0
PYH3_k127_9625811_10 TIR domain - - - 0.0000000000000000000000007191 111.0
PYH3_k127_9625811_11 PFAM peptidase U32 K08303 - - 0.00000000000000000000299 96.0
PYH3_k127_9625811_12 - - - - 0.00000000000000003048 91.0
PYH3_k127_9625811_13 - - - - 0.00000000000000003176 85.0
PYH3_k127_9625811_14 Domain of unknown function (DUF4405) - - - 0.000000000000007886 81.0
PYH3_k127_9625811_15 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000005084 78.0
PYH3_k127_9625811_17 - - - - 0.0003288 48.0
PYH3_k127_9625811_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 404.0
PYH3_k127_9625811_3 Putative NAD(P)-binding K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001737 274.0
PYH3_k127_9625811_4 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004063 276.0
PYH3_k127_9625811_5 TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000001419 227.0
PYH3_k127_9625811_6 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
PYH3_k127_9625811_7 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000002085 190.0
PYH3_k127_9625811_8 - - - - 0.00000000000000000000000000000003041 136.0
PYH3_k127_9625811_9 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000001326 123.0